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5 results on '"BACCELLIERE D"'

3. Tissue expanders in neurosurgery

Author

PARLATO, Ciro, ROTONDO, Michele, IACCARINO C, BACCELLIERE D., Parlato, Ciro, Rotondo, Michele, Iaccarino, C, and Baccelliere, D.

Published
1995

4. 'Espansori cutanei in neurochirurgia'

Author

ROTONDO, Michele, PARLATO, Ciro, Iaccarino C, Baccelliere D., Rotondo, Michele, Parlato, Ciro, Iaccarino, C, and Baccelliere, D.

Published
1994

5. Peptidyl succinimidyl peptides as taspase 1 inhibitors.

Author

van den Boom J, Mamić M, Baccelliere D, Zweerink S, Kaschani F, Knauer S, Bayer P, and Kaiser M

Subjects
Dose-Response Relationship, Drug, Humans, Molecular Conformation, Peptides chemical synthesis, Peptides chemistry, Protease Inhibitors chemical synthesis, Protease Inhibitors chemistry, Structure-Activity Relationship, Endopeptidases metabolism, Peptides pharmacology, Protease Inhibitors pharmacology
Abstract

Taspase 1 is an N-terminal threonine protease implicated in leukemia and other cancers. Despite intensive efforts in recent years, only a limited number of Taspase 1 inhibitors are currently available, and they lack general applicability. Here we present a novel class of Taspase 1 inhibitors based on a peptidyl succinimidyl peptide motif. These inhibitors were obtained from the substrate cleavage sequence and mechanistic considerations involving the previously proposed asparaginase-type cleavage mechanism. We anticipate that this class of Taspase 1 inhibitor will find wide application in further biochemical and structural studies, for example for better investigating the molecular details of the unusual enzymatic cleavage mechanism of Taspase 1., (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2014
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