Search

Background: Primary stability (PS) is dependent on the length and diameter of the implant, micro-morphology of the implant surface, implant design, surgical procedure, bone quantity, and quality. This study aimed to compare short and standard dental implants according to primary stability in bone type IV using Resonance frequency analysis (RFA) test equipment. Methods: Seventy two dental implants; sandblasting with large grit particles and acid etching (SLA) surface (Dentium®,SimpleLine II, Seoul, Korea), SLActive surface- (Straumann Roxolid®, Basel, Switzerland), Resorbable blast media (RBM) surface- (Implance®, Trabzon, Turkey) with very short (4-mm length), short (6-mm length) and standard dental implants (10-mm length) were placed in bovine cow ribs with bone quality similar to a type IV human bone. RFA was performed to evaluate the primary stability. One-way ANOVA test was used to compare the groups ve different groups were assessed with the post hoc Tukey test. Results: Implant stability quotient (ISQ) measurements of 4-mm and 6-mm length implants were similar however, 10-mm-length implants showed statistically difference inter-groups. SLActive surface in 10-mm-length implant group showed highest ISQ value (p, Amaç: Primer stabilite (PS), implantın uzunluğuna ve çapına, implant yüzeyinin mikro morfolojisine, implant tasarımına, cerrahi prosedüre, kemik miktarına ve kalitesine bağlıdır. Bu çalışmanın amacı, çok kısa, kısa ve standard dental implantları Tip IV kemikte primer stabilitelerine göre Rezonans Frekans Analizi (RFA) test ekipmanı kullanarak karşılaştırmaktır. Gereç ve Yöntemler: Yetmiş iki dental implant; Large grit kumlanmış ve asitlenmiş (sandblasting with large grit particles and acid etching, SLA) (Dentium®, SimpleLine II, Seul, Kore), SLActive yüzey- (Straumann Roxolid®, Basel, İsviçre), Resorbable blast media (RBM) yüzey- (Implance®, Trabzon, Türkiye) çok kısa (4 mm uzunluğunda), kısa (6 mm uzunluğunda) ve standard dental implantlar (10 mm uzunluğunda) insan tip IV kemiğine benzer kemik kalitesine sahip sığır türü kaburgaya yerleştirildi. Grupları karşılaştırmak için tek yönlü ANOVA testi kullanıldı ve farklı gruplar post hoc Tukey testi ile değerlendirildi. Bulgular: Dört ve 6 mm uzunluktaki implantların İmplant Stabilite Katsayısı (Implant stability quotient, ISQ) ölçümleri benzerdi, ancak 10 mm uzunluktaki implantlarda gruplar arasında istatistiksel olarak anlamlı fark gözlendi. On mm uzunluğundaki implant grubunda SLActive yüzey en yüksek ISQ değerini gösterdi (p

Amaç: Bu çalışmada Bolu ve çevresinde yaşayan süt ve karışık dişlenme döneminde bulunan çocuklarda labial frenulum tiplerini ve gingival sağlığa etkilerini değerlendirmek amaçlanmıştır. Gereç ve Yöntemler: Bolu Abant İzzet Baysal Üniversitesi Diş Hekimliği Fakültesi Hastanesi’nde gerçekleştirilen çalışmaya 3–16 yaşlarındaki 205 çocuk (%49,7 erkek, %50,3 kız) dahil edildi. Çocukların %49,3’ü 3–6 yaşlarında olup süt dişlenme, %50,7’si 7–16 yaşlarında olup karışık dişlenme göstermekteydi. Maksillar labial frenulum (MLF) tipleri Mirko sınıflamasına göre sınıflandırıldı; gingival indeks skorlaması ise Löe–Silness sınıflamasına göre yapıldı. Bulgular: MLF tipleri bakımından iki cinsiyet arasında istatistiksel olarak anlamlı fark yoktu. Hem süt hem de karışık dişlenme döneminde en sık gingival tip frenulum tespit edildi. Frenulum tipleri bakımından gruplar arasında anlamlı fark bulunmadı. Her iki yaş grubunda da papile penetre formdaki frenulumlarda gingival indeks skorlarının anlamlı biçimde daha yüksek olduğu tespit edildi. Tartışma ve Sonuç: Frenulum uzunluğunun normal sınırlar dışında olması diş eti çekilmelerine, dizilim bozulmalarına, diş çürüklerine ve konuşma problemlerine sebep olabilir. Bu nedenle çocuklarda ağız–diş muayenesi sırasında frenulum değerlendirmesine de önem verilmelidir. Aim: In this study, we aimed to evaluate the labial frenulum types and their effects on gingival health in children with primary and mixed dentition who live in and around the city of Bolu. Materials and Methods: The study was conducted at the Dentistry Faculty Hospital of the Bolu Abant İzzet Baysal University and included a total of 205 children (50.4% boys, 49.6% girls) aged 3 to 16 years. Of the children, 49.3% were 3 to 6 years old with primary dentition, and 50.7% were 7 to 16 years old with mixed dentition. The maxillary labial frenulum (MLF) type classification was made according to the Mirko classification and the gingival index scoring was performed according to the Löe–Silness classification. Results: There was no statistically significant difference between the two sexes in terms of MLF types. In both primary and mixed dentition stages, the most common frenulum type was the gingival type. No significant difference was found between the groups in terms of frenulum types. In both age groups, gingival index scores were found to be significantly higher in frenula of the papillary penetrating type. Discussion and Conclusion: Frenulum lengths outside the normal range may lead to gingival recession, tooth malposition, tooth decay, and speech problems. For this reason, it is important that pediatric oral and dental examinations include a frenulum evaluation.

Objective The aim of this study was to assess the effect of fixed orthodontic treatments with steel-ligated conventional brackets and self-ligating brackets (SLBs) on periodontal clinical parameters. Materials and Methods Seventy-seven patients (24 male and 53 female) aged between 18 and 30 years were enrolled in the study. Periodontal parameters including plaque index (PI), gingival index (GI), and bleeding on probing (BOP) index were obtained from all the bonded teeth. Results When the effect of bracket type and duration of treatment on gingival tissues was examined, there was no statistically significant difference between the treatment times (P = 0.670) and bracket types (P = 0.596) in terms of PI. The GI was significantly different between the different treatment durations (P = 0.045); it was higher in patients with a treatment duration of 18–36 months. However, the GI did not change according to the bracket types (P = 0.270). This result was not significantly different between different treatment durations (P = 0.270). There was no significant difference between the treatment periods (P = 0.189) in terms of BOP index, and this result did not change according to the bracket types (P = 0.621). Conclusion SLBs do not require ligatures, which may facilitate plaque accumulation. However, our results showed that SLBs were not advantageous over CBs in terms of periodontal health.

Amaç: Psoriazis vulgaris tanılı hastalarda oral bulgu varlığı ve bu bulguların hastalığın klinik özellikleriyle ilişkisini araştırmak ve hastaların ağız ve diş sağlığını değerlendirmektir. Yöntemler: Psoriazis vulgaris tanılı 85 hasta ile kontrol grubunu oluşturmak üzere 100 birey çalışmaya dahil edildi. Tüm bireylerde oral bulgu, obezite varlığı, çürük, kayıp ve dolgulu diş (decayed, missing, filled, teeth) (DMFT) değerleri ile ağız ve diş sağlığı değerlendirildi. Bulgular: Fissürlü dil ve coğrafik dil sıklığı hasta grubunda anlamlı oranda yüksekti (sırasıyla, p0,05). Hasta grubu klinik özelliklerine göre değerlendirildiğinde, geç başlangıçlı psoriazis hastalarında erken başlangıçlılara kıyasla, obez psoriazis hastalarında obez olmayanlara kıyasla diş kaybı daha fazla iken; erken başlangıçlı psoriazislilerde geç başlangıçlı psoriazislilere kıyasla ve immünosüpresif tedavi almayan psoriazis hastalarında immünosüpresif tedavi alan psoriazis hastalarına kıyasla dolgulu diş sayısı daha yüksekti (sırasıyla, p=0,017; p=0,002; p=0,038; p=0,019). Sonuç: Psoriazis hastalarının ağız ve diş sağlığı açısından düzenli muayenesi ve bilgilendirilmeleri, diş sağlığının korunmasında fayda sağlayabilir. Objective: To investigate the presence of oral findings and relationship between these findings and clinical features in patients with psoriasis vulgaris, and to evaluate the oral and dental health of the patients. Methods: This study included 85 patients with psoriasis vulgaris and 100 participants as a control group. Oral findings, presence of obesity, decayed, missing, filled, teeth (DMFT) values, and oral and dental health were evaluated in all participants. Results: The frequency of fissured tongue and geographic tongue was significantly higher in the patient group (p0.05). When the patient group was evaluated according to clinical characteristics of the disease, the number of missing teeth was higher in patients with late-onset psoriasis than early-onset group, and in patients with obese than nonobese group, whereas the number of filled teeth was higher in patients with earlyonset psoriasis than late-onset group, and patients non-receiving immunosuppressive treatment than patients receiving immunosuppressive treatment (p=0.017; p=0.002; p=0.038; p=0.019, respectively). Conclusion: Regular examination and informing of psoriatic patients in terms of oral and dental health may be beneficial in maintaining dental health.

WOS: 000509391800015 PubMed: 31588098 The purpose of this study was to evaluate the effects of administered Paeoniflorin (Pae) on periodontal tissues within an experimental periodontitis model. Forty male Wistar rats were used in this study and experimental periodontitis was created in all rats except in the control group (n = 10, first group). In the periodontitis group, experimental periodontitis was created but no other application was performed (n = 10, second group). In the other groups created experimental periodontitis, systemic Pae (n = 10, third group) or saline (n = 10, fourth group) was applied. A biochemical analysis of the gingival vascular endothelial growth factor (VEGF) levels and a histomorphometric analysis (measurements of the area of alveolar bone, alveolar bone resorption, and attachment loss) were performed. In the Pae group, the area of the alveolar bone was increased, while alveolar bone resorption and attachment loss decreased. Gingival VEGF levels increased in all groups that created experimental periodontitis and the greatest increase seen in the Pae group. Histomorphometric and biochemical analyses in this study suggest that Pae has a curative effect on periodontal tissues. However, additional studies are needed to confirm these results. Scientific Research Fund of Ondokuz Mayis University in Samsun/TurkeyOndokuz Mayis University [PYO.DIS.1904.15.001] This study was supported by the Scientific Research Fund of Ondokuz Mayis University in Samsun/Turkey (Project number: PYO.DIS.1904.15.001).

Mohammad Hassan Hamrah,1,2 Ali Baghalian,1 Sara Ghadimi,1 Saeedeh Mokhtari,1 Mojgan Kargar,3 Maryam Khosrozadeh,1 Toba Dahi,4 Abdurrahman Charkazi,5 Mohammad Shoaib Hamrah,6 Mohammad Hussain Hamrah2 1Department of Paediatric Dentistry, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran; 2Curative Clinic, Andkoy, Faryab, Afghanistan; 3Department of Paediatric Dentistry, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; 4Abant Izzet Baysal University Faculty of Dentistry, Bolu, Turkey; 5Health Education and Promotion, Environmental Health Research Center, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran; 6Shaheed Ostad Esmail”Aslam” Aimaq Hospital, Anadkhoy, Faryab Province, AfghanistanCorrespondence: Mohammad Hussain HamrahCurative Clinic Andkhoy, Amir Timor Street, Shari now, Andkhoy, AfghanistanEmail hkmu1991@gmail.comBackground: Fissured tongue is a common manifestation of the tongue, marked by the presence of multiple prominent grooves or fissures on the dorsal surface of the tongue. However, there is a lack of studies focusing on the prevalence and factors associated with fissured tongue among patients attending an outpatient clinic in Afghanistan.Aim: The purpose of the current study was to determine the prevalence and factors associated with fissured tongue and its effects on the general health of adult outpatients in Afghanistan.Patients and Methods: The cross-sectional survey was conducted among outpatient populations in Andkhoy City, Afghanistan, between September 2019 and December 2019. A convenience technique was applied by including 1182 patient aged 18– 80 years. Socio-economic status, smoking, nass use (smokeless tobacco use) and medical data were collected using face-to-face interviews. We used logistic regression analysis to identify factors associated with fissured tongue. A convenience technique was applied by including patient aged 18– 80 years.Results: The studied population consisted of 1182 participants, of whom 573 (48.5%) were males and 609 (51.5%) females. The prevalence of fissured tongue was 27.2% (95% CI: 24.7– 29.9%) with males having significantly higher prevalence than females (47.5%, 95% CI: 43.3– 51.6% versus 8.2%, 95% CI: 6.2– 10.7%, p< 0.001). Male participants (OR=7.1, 95% CI: 4.8– 10.3), diabetes mellitus (OR=1.6, 95% CI: 1.1– 2.3) and smokeless tobacco use (OR=12.0, 95% CI: 8.1– 17.6) were the only variables independently associated with fissured tongue.Conclusion: This study suggested that there was a high rate of fissured tongue among an outpatient clinic in Andkhoy, Afghanistan. Male gender, diabetes mellitus, and nass consumption were associated with fissured tongue. Therefore, these factors might usefully be targeted in local health promotion, prevention and early intervention programs.Keywords: fissured tongue, prevalence, risk factors, Andkhoy, Afghanistan

Background The aim of this paper is to explore the serum biochemical parameters also known as risk markers for cardiovascular system, in individuals who have received dental implant treatment, and to reveal risk factors for peri-implant diseases. Methods The study included 58 subjects with peri-implantitis, 49 subjects with peri-implant mucositis, and 49 healthy subjects. All the subjects were assessed in terms of both peri-implant clinical parameters—probing depth (PD), bleeding on probing (BOP), the type of prosthesis, gingival index (GI), keratinized mucosa width (KMW), and plaque index (PI)—and serum biochemical parameters (e.g., LDL cholesterol, HDL cholesterol, triglyceride, total cholesterol, vitamin D, uric acid, white blood cell (WBC), neutrophil, hemoglobin (Hb), and platelet counts). Results KMW was the lowest in the peri-implantitis group. Compared with the other groups, the peri-implantitis group showed significantly higher levels of triglyceride, uric acid, and WBC. The peri-implantitis group had the lowest level of vitamin D. Triglyceride and uric acid levels had positive correlations with peri-implant clinical parameters. Conclusion High levels of triglyceride and uric acid may pose a risk for both peri-implant diseases and cardiovascular diseases. Prior to dental implant surgery, patients’ serum biochemical parameters should be checked.

Background The aim of this cross-sectional study was (1) to determine the prevalence of peri-implant mucositis and peri-implantitis and (2) to reveal the risk indicators associated with peri-implant diseases. The second point was to investigate the role of keratinized mucosa on peri-implant health. Materials and methods Three hundred and eighty-two subjects who were treated with 1415 dental implants between 2011–2017 were clinically evaluated. Patients’ medical and dental history, as well as implant details, were recorded. Peri-implant examination included probing pocket depth (PPD), bleeding on probing (BoP), plaque index (PI), gingival index (GI), and keratinized tissue width. Furthermore, the patient (sex, age, and smoking) and implant/prosthesis-related factors (surface characteristic, time in function, design of prosthesis etc.) were evaluated. Implants were classified into three groups: healthy, peri-implant mucositis, and peri-implantitis. Uni- and multi-variate regression analyses were utilized for statistics. Results 41.1% (n = 157) and 36.9% (n = 84) of patients had mucositis and peri-implantitis, respectively. 53.6% (n = 758) of implants (95%CI 80.2–90.4) had mucositis, and 21.7% (n = 307) had peri-implantitis. Patients with a maintenance < 2/year (OR = 2.576), having periodontitis (OR = 3.342) and higher PI (OR = 3.046) had significant associations with the development of peri-implant mucositis. Significant ORs were determined for peri-implantitis with patients having maintenance < 2/year (OR = 2.048), having number of implants ≥ 4 (OR = 2.103), diagnosed with periodontitis (OR = 3.295), and higher PI (OR = 7.055). Keratinized tissue width < 2 mm (ORs = 5389/8.013), PPD (ORs = 1.570/8.338), PI (ORs = 6.726/5.205), and BoP (ORs = 3.645/4.353) independent variables were significantly associated with both peri-implant mucositis and peri-implantitis at implant level, respectively. Conclusions Within the limits of this study, the prevalence of mucositis and peri-implantitis was shown to be high in Turkish population. Furthermore, increased risk for peri-implantitis was identified in patients having maintenance < 2/year, presence of periodontitis, poor plaque control, and having number of implants ≥ 4. Less keratinized tissue (< 2 mm), PPD, and BoP were also risk indicators for peri-implantitis development.

WOS:000604611100002 Background and Design: Isotretinoin is a vitamin A isomer, and is the most commonly used drug for the treatment and for achieving remission in severe acne. This study aimed to evaluate the effects of isotretinoin on periodontal tissues by assessing the clinical periodontal parameters and salivary oxidative stress (OS) markers. Materials and Methods: Twenty-five patients (17 women and 8 men) aged between 20 to 25 years old, who were identified as candidates for the treatment of acne with isotretinoin; and 18 healthy volunteers (14 women and 4 men), who were age- and sex-matched with the patients, and who did not have any inflammatory skin diseases or periodontal diseases, were included in the study. Patients received isotretinoin after their clinical periodontal parameters were recorded and saliva was collected at the baseline. Clinical periodontal parameters and salivary oxidative biomarkers were evaluated before and after 6 months of isotretinoin treatment. Results: The baseline periodontal clinical parameters and salivary biomarkers were not statistically different between groups (p>0.05). The total antioxidant capacity (TAC) values of the patient group were found out to be statistically decreased in the sixth month compared to the baseline (p=0.001). Conclusion: The study demonstrated that the use of isotretinoin due to acne vulgaris did not create significant changes in the periodontal tissues, but caused a significant decrease in the TAC levels. These alterations in the OS regulation may potentially take part in the pathological mechanisms involved in the emergence of isotretinoin's adverse effects.

Aim: There is a growing evidence that periodontal disease is associated with an increased risk of cardiovascular diseases. To assess the awareness levels, views, and clinical practices of cardiologists and cardiovascular surgeons in Turkey on the association of periodontal diseases with the diseases of the cardiovascular system.Material and Methods: A survey that included twenty-three questions was prepared and mailed to 99 cardiologists and cardiovascular surgeons practicing as resident, lecturer or specialist in Turkey. The response rate is 66%. Data was analyzed using SPSS® 18.0 software (SPSS, Chicago, IL, USA). Results: Of the respondents; 80% were males, 98% were at the age of ≤ 50 years, 59% have been working in a university, and 37% were specialists. Fifty-three percent of lecturer and 38% of specialist received a periodontal treatment more than two years time ago. Fourteen percent of resident, 30% of specialist and 53% of lecturer referred patients to visit the dentist. Eighty-eight percent of the residents and lecturers agreed or strongly agreed with the opinion that periodontal disease treatment could lower the risk of an individual to develop a type of cardiovascular disease. Conclusion: Cardiologists and cardiovascular surgeons had a lack of knowledge of the periodontal disease and its impact on systemic health. Programs on oral health in academic curricula of cardiologists and cardiovascular surgeons should be improved to leverage the level of awareness and knowledge on periodontal diseases.Keywords: Cardiologists, cardiovasvular surgeons, cardiovascular diseases, periodontal diseases, oral health.Kardiyologların ve KardiyovaskülerCerrahların Periodontal Hastalık ve Kardiyovasküler Hastalık Arasındakiİlişkisi ile İlgili Farkındalık, Görüş ve Uygulama DavranışlarıAmaç: Periodontal hastalığın artmışkardiyovasküler hastalık riski ile ilişkili olduğuna dair kanıtlar artmaktadır.Bu çalışmanın amacı kardiyologların ve kardiyovasküler cerrahların periodontalhastalık ve kardiyovasküler hastalık arasındaki ilişki ile ilgili farkındalık,görüş ve uygulama alışkanlıklarını değerlendirmektir.Gereç ve yöntem: Yirmi üç sorudan oluşananket hazırlanmış ve Türkiye’de uzman, öğretim üyesi veya asistan olarakçalışan 99 kardiyolog ve kardiyovasküler cerraha mail yoluyla gönderilmiştir.Anketin cevaplanma oranı %66’dır. Veriler SPSS® 18.0 yazılımı (SPSS,Chicago, IL, USA) kullanılarak analiz edilmiştir. Bulgular: Katılımcıların % 80'i erkekve % 98'i 50 yaşında veya daha gençtir. Katılımcıların %59’u üniversitedeçalışıyor ve %37'si uzman olarak görev yapmaktadır. Öğretim elemanının %53’ü veuzmanların % 38'i iki yıldan uzun zaman önce periodontal tedavi görmüştür. Asistanların%14’ü, uzmanların % 30'u ve öğretim elemanının % 53'ü hastalarını diş hekiminegitmesi için sevk etmektedir. Asistanların ve öğretim elemanlarının %88’iperiodontal hastalığın tedavisinin hastanın kardiyovasküler hastalık riskiniazaltabileceği konusuna katılmakta veya çok güçlü katılmaktadır. Sonuç: Kardiyologlar ve kardiyovasküler cerrahlar periodontalhastalık ve periodontal hastalığın sistemik sağlık üzerindeki etkisi hakkında yetersizbilgiye sahiptir. Kardiyolog ve kalp damar cerrahların akademik müfredatlarındaağız diş sağlığı üzerine programlar, periodontal hastalıklar hakkındakifarkındalık ve bilgi seviyesini arttırmak için geliştirilmelidir. Anahtar kelimeler: Kardiyologlar,kardiovasküler cerrahlar, cardiovascular diseases, periodontal hastalıklar,ağız sağlığı

SUMMARY OBJECTIVE Periodontitis may stimulate infectious and immune response and cause the development of atherogenesis, coronary heart disease, and myocardial infarction. The aim of this study was to compare the plateletcrit (PCT) and mean platelet volume (MPV) levels derived from complete blood count (CBC) tests in patients suffering from stage 3 periodontitis with those of healthy individuals without periodontal disease. METHODS The study included 57 patients (28 females and 29 males) with Stage 3 Periodontitis and 57 volunteering individuals (31 females and 26 males) who were periodontally healthy. The age of study participants ranged from 18 to 50 years. Their periodontal condition was investigated with probing depth (PD), clinical attachment level, bleeding on probing, and plaque index. Leukocyte (WBC) and erythrocyte count (RBC), hemoglobin (Hb) and hematocrit (HCT) levels, mean corpuscular volume (MCV) and red cell distribution width (RDW), thrombocyte count, mean platelet volume (MPV), plateletcrit (PCT ), and neutrophil and lymphocyte counts were evaluated based on the CBC test results of the study participants. RESULTS PCT, WBC, Neutrophil, and MPV values were found to be significantly higher in the periodontitis group (p0.05). CONCLUSIONS PCT and MPV levels may be a more useful marker to determine an increased thrombotic state and inflammatory response in periodontal diseases. RESUMO OBJETIVO A periodontite pode estimular a resposta infecciosa e imunitária e causar o desenvolvimento da aterogênese, doença coronária e infarto do miocárdio. O objetivo deste estudo foi comparar os níveis de plaquetócrito (PCT) e de volume médio de plaquetas (VMP) derivados dos testes de hemograma completo (CBC) em doentes que sofrem de periodontite de fase 3 com os de indivíduos saudáveis, sem doença periodontal. MÉTODOS O estudo incluiu 57 doentes (28 mulheres e 29 homens) com periodontite de fase 3 e 57 voluntários (31 mulheres e 26 homens) que eram periodontalmente saudáveis. A idade dos participantes do estudo variou de 18 a 50 anos. A condição periodontal dos participantes do estudo foi investigada com profundidade de sonda (PD), nível de ligação clínica, hemorragia na sonda e índice de placas. Contagem de leucócitos (WBC) e eritrócitos (RBC), níveis de hemoglobina (Hb) e hematócrito (HCT), volume corpuscular médio (VCM) e largura de distribuição das células vermelhas (RDW), contagem de trombócitos, volume plaquetário médio (MPV), plaquetócrito (PCT) e contagem de neutrófilos e linfócitos foram avaliados com base nos resultados do teste CBC dos participantes do estudo. RESULTADO Verificou-se que os valores de PCT, WBC, neutrófilos e MPV eram significativamente mais elevados no grupo da periodontite (p0, 05). CONCLUSÃO Os níveis de PCT e MPV podem ser um marcador mais útil para determinar um estado trombótico aumentado e a resposta inflamatória em doenças periodontais.

Background Titanium- prepared platelet rich fibrin (T-PRF) is an autologous hemo-component with a high concentration of platelets that also incorporates leukocytes, and growth factors into the dense fibrin matrix and can be used as a healing biomaterial. This study assesses the adjunctive use of T-PRF in intrabony defects (IBDs) with open flap debridement (OFD) in comparison with guided tissue regeneration (GTR) as a gold standard and OFD alone as a control. Material and Methods A total of 45 patients (15 per group) were randomized as either T-PRF (test group), GTR (test group), or OFD alone (control group) sites. Probing depth (PD), clinical attachment level (CAL), and IBD were recorded. The radiographic depth of IBD was also measured. Primary outcomes assessed were changes in PD, CAL, and radiographic IBD that were assessed at the beginning and nine months later. Results The PRF and GTR group showed significant improvement in clinical parameters compared with the OFD alone (control group) at nine months. While there were no significant differences in PD and CAL between test groups (T-PRF and GTR groups), the significant difference was found in radiographic IBD depth. Conclusions T-PRF may give similar successful results as GTR in the treatment of IBDs with endo-perio lesions. Key words:Flap surgery, guided tissue regeneration, intrabony defects, periodontitis, root canal therapy.

Background: The aim of this study was to assess the trabecular bone pattern changes of orthodontically treated patients before orthodontic treatment (T0), immediately after (T1) and 6 months after (T2) the treatment by using fractal dimension (FD) analysis in order to guide implant applications. Methods: Totally 32 orthodontic patients who had one missing tooth were included in the study. Patients were treated to align the teeth and to create a dimensionally appropriate space for implant placement. Panoramic radiographs were taken with standard protocols at the time periods of before (T0), immediately after (T1) and 6 months after (T2) treatment. FD analysis was performed using Image J 1.3 software with the boxcounting method. Results: The highest FD value was measured before treatment (T0=1.47±0.14). Mean FD values of T2 was found statistically significantly higher (1.32±0.14) than T1 (1.19±0.15) (p, Amaç: Bu çalışmanın amacı, ortodontik tedavi gören hastaların implant tedavisinde rehber olması amacıyla, ortodontik tedavi öncesinde (T0), hemen sonrasında (T1) ve 6 ay sonrasında (T2) trabeküler kemik değişikliklerini fraktal boyut (FD) analizini kullanarak değerlendirmektir. Gereç ve Yöntemler: Çalışmaya bir dişi eksik olan toplam 32 ortodonti hastası dahil edildi. Hastalar dişleri hizalamak ve implant yerleştirmek için boyutsal olarak uygun bir alan oluşturmak için tedavi edildi. Panoramik radyografiler standart protokollerle sabit ortodontik tedavi öncesinde (T0), hemen sonrasında (T1) ve 6 ay sonrasında (T2) alındı. FD analizi Image J 1.3 yazılımı kullanılarak kutu sayma yöntemiyle yapıldı. Bulgular: En yüksek FD değeri tedavi öncesinde ölçüldü (T0 = 1.47 ± 0.14). T2' nin ortalama FD değeri (1.32 ± 0.14), T1'den (1.19 ± 0.15) istatistiksel olarak anlamlı derecede yüksek bulundu (p

Introduction: Ventricular arrhythmic predictors in severe periodontitis may be linked with cardiovascular events and the sudden death risk. In this study, we evaluated certain electrocardiographic (ECG) ventricular arrhythmic predictors in patients with severe periodontitis. Methods: ECG parameters of 72 patients diagnosed with severe periodontitis, which are indicative of ventricular arrhythmia, were examined, and these parameters were compared with the control group.Results: Compared to the control group, QT interval (QT)(p=0.014), corrected QT (QTc) (p

Deneyhayvanları, araştırmalarda ve biyolojik testlerde ilaç, madde, tedavi gibietkinliklerin, canlı organizmadaki sonuçlarının elde edilmesi için kullanılanhayvanlardır. Deney hayvanlarının bilimsel deneylerde kullanılmaya başlamasıylabirlikte araştırma verilerinin istenildiği kadar tekrarlanabildiği ve istenenkoşullar da yeniden elde edilebildiği görülmüştür. Bu hayvanlar sağlıkbilimleriyle ilgili birçok biyolojik testte kullanılabildiği gibi diş hekimliğiaraştırmalarında da sıklıkla kullanılmaktadır. Hayvan çalışmaları periodontal araştırmalar için yeni tedavilerindenenmesi öncesinde tamamlayıcı özelliktedir. Hayvan modelleri hipotezlerindoğrulanmasını mümkün kılmalı ve yenilenen yaklaşımların güvenilirliğini veetkinliğini ispatlamalıdır. Uygun hayvan modelinin seçimi periodonsiyumun vehastalığın doğasının insanlardakine benzerliğine bağlıdır. İnsanlardaki periodontitisi modellemek için;kemirgenler, köpekler, insan olmayan primatlar, tavşanlar gibi farklı türlerdebirçok hayvan modeli kullanılmıştır. Ancak her deney hayvan modelinin kendineözgü avantaj ve dezavantajı bulunmaktadır. Her bir türün, farklı beslenmeleri,ömrü, doku yapısı, alışkanlıkları, genetik özellikleri ve konak savunmamekanizmaları olduğundan uygun deneysel modeli belirleyebilmekzorlaşabilmektedir. Araştırmacı deney hayvan modelini oluştururken planladığıçalışmaya uygun hayvanı ve defekt modelini seçebilecek bilgiye sahip olmalıdır.Çalışılacak hayvanın özellikleri dikkatle incelenmelidir. Bu derlemenin amacıperiodontoloji alanındaki araştırmalar için en uygun hayvan ve hastalıkmodelini tanımlamaya yardımcı olmaktır.Anahtar Kelimeler: Deney hayvanları, hastalık modelleri, defekt modeliEXPERIMENTAL DISEASE AND ANIMAL MODELS INPERIODONTOLOGY ABSTRACTExperimentalanimals were used for obtaining results in living organisms of activities suchas medication, substance and treatment in research and biologic tests. It isseen that research data as well as desired conditions can be repeated andobtained as much as required since the beginning of use of experimental animalsin scientific experiments. While these animals can be used in many biologictests related to health sciences, they are also frequently used in dentalresearch. Animal studies arecomplementary before testing new therapies for periodontal investigations. Animalmodels should allow validation of hypothesis, and prove reliability andefficiency of new approaches. Selection of suitable animal model depends onsimilarity of nature of periodontium and the disease with those of human. Manyanimal models have been used in different species such as rodents, dogs,non-human primates, rabbits. However, each experimental animal model hasspecific advantages and disadvantages. Determining the suitable experimentalmodel becomes difficult as each species has different nutrition, lifetime,tissue structures, habits, genetic features and host defense mechanisms.Researchers must have the adequate knowledge to select the suitable experimentalanimal and defect model. Characteristics of the animal to be studied should becarefully examined. The aim of this review is to help defining the mostsuitable animal and disease models for researches in periodontology.Key Words: Experimental animals, disease models, defect models

Amaç: Gebe olan ve olmayan jinjivitli kadınlar arasında ağız sağlığı ile ilgili yaşam kalitesi (OHRQoL) açısından fark olup olmadığı araştırmak ve gruplar arasında cerrahi olmayan periodontal tedavinin yaşam kalitesi üzerine etkisini değerlendirmektir. Gereç ve Yöntemler: Bu çalışmaya test grubu olarak 50 gebe kadın (ortalama yaş 28,78±3,69 yıl) ve kontrol grubu olarak 42 gebe olmayan kadın (ortalama yaş 27,59±5,66 yıl) dâhil edildi. Bireyin algılanan OHRQoL’sini belirlemek için Ağız Sağlığı Etki Profili-14 (OHIP-14) anketi kullanıldı. Periodontal durumunu belirlemek için jinjival indeks (Gİ), plak indeksi (Pİ), sondalama cep derinliği (SCD) ve sondalamada kanama indeksi (SKİ) ölçümleri yapılmıştır. Bulgular: Gebelik jinjiviti olan kadınlar (test grubu) için toplam OHIP skoru 18,46±15,82, gebe olmayan jinjivitli kadınların (kontrol grubu) toplam OHIP skoru 14,14±7,94’dür. Test ve kontrol grubu arasında istatistiki anlamlı fark yoktur. 'Fiziksel yetersizlik' alt grubunda gebe olan ve olmayan kadınlar arasında istatistiki anlamlı fark vardı. Test grubu için ortalama SCD ve Gİ kontrol grubundan anlamlı derecede daha yüksek bulundu. Periodontal tedaviden sonra iki grupta da OHRQoL skorlarında düşüş gözlendi. Sonuç: Gebelik jinjiviti olan kadınlarda periodontal sağlık, gebe olmayan jinjivitli kadınlardan daha zayıftı. Jinjivit, ağız sağlığına bağlı yaşam kalitesi üzerine etkilidir. Daha yüksek puanlar, daha düşük bir OHRQoL olduğunu göstermektedir. Ağız sağlığı ile ilişkili yaşam kalitesinin artırılabilmesine yönelik olarak, gebelik döneminden önce ve gebelik döneminde düzenli yapılan diş hekimi kontrolleri ile atravmatik ve etkili tedavi uygulamalarıyla periodontal durumun, dolayısıyla ağız sağlığının iyileştirilmesi gerekli görülmektedir. Objective: The aim of this study is to assess the differences in oral health-related quality of life (OHRQoL) between pregnant and non-pregnant women with gingivitis and to evaluate the effect of non-surgical periodontal treatment on quality of life in all groups. Material and Methods: This study included 50 pregnant women (mean age 28.78±3.69) and 42 non-pregnant women (mean age 27.59±5.66). The Oral Health Impact Profile-14 (OHIP-14) questionnaire was used to determine the OHRQoL of the individuals. Periodontal status was defined using gingival index (GI), plaque index (PI), probing pocket depth (PPD) and bleeding on probing (BOP) measurements. Results: The total OHIP-14 scores for pregnant women with pregnancy gingivitis (test group) were 18.46±15.82 and non-pregnant women with gingivitis were 14.14±7.94. There was no significant difference between groups. There was a statistically difference between the test and control groups in the 'physical disability' subgroup. The mean PPD and GI scores were significantly higher in the test group than control group. There was a decrease in OHRQoL scores in both groups after periodontal treatment. Conclusion: Periodontal status of women with pregnancy gingivitis was poor than non-pregnant women with gingivitis. Gingivitis effects on the oral health-related quality of life. High OHIP14 scores indicate the low oral health-related quality of life. To increase the OHRQoL, periodontal status and oral health should be improved by regular dental visits, atraumatic treatment applications before and during pregnancy.

WOS:000472779400008 Bone mineral density (BMD) is reduced due to the antiepileptic drug (AED) use. This retrospective study aimed at comparing the fractal dimension (FD) and mandibular indices in certain regions on dental panoramic radiographs (DPRs) of patients using AED and also of healthy individuals. In 34 patients with epilepsy using AED and in 34 healthy subjects, panoramic mandibular index (PMI), mandibular cortical width (MCW), mandibular cortical index (MCI), and fractal dimension (FD) of four different regions were assessed using DPRs. FD, measured in the condylar, second premolar and angulus regions, and the mean FD values were significantly lower in the affected patients (p=0.027, p=0.001, p=0.032, p=0.006 respectively). The mean PMI was higher in controls (p=0.001), yet MCI were similar in both groups (p=0.765). FD analysis and radiomorphometric indices in panoramic radiographs can be used to evaluate osteoporotic changes in patients using AEDs.

WOS:000375843400009 PubMed: 26751342 Background: This study aims to investigate the effects of a 2% cholesterol-enriched diet on alveolar bone loss (ABL) and serum levels of pro-oxidants and antioxidant enzymes in rats with experimental periodontitis. Methods: Rats were randomized into the four groups: 1) group C (standard diet/periodontally healthy); 2) group Hc (high-cholesterol diet); 3) group HcP (high-cholesterol diet/periodontitis); and 4) group P (standard diet/periodontitis). All rats were fed for 8 weeks. At 6 weeks, experimental periodontitis was induced. At the end of week 8, the rats were sacrificed. Histomorphometric and histopathologic analyses were performed. Malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase, and glutathione peroxidase (GPX) levels in serum were measured with enzyme-linked immunosorbent assay. Results: Experimental groups exhibited increases in: 1) total cholesterol, 2) low-density lipoprotein, and 3) high-density lipoprotein compared to group C. The cholesterol-enriched diet induced ABL in group Hc; groups HcP and P had more extensive ABL. The most polymorphonuclear leukocyte infiltration in periodontal tissues was found in group HcP. MDA levels were higher in all experimental groups than in group C, but significant in the HcP group. A high-cholesterol diet, with or without periodontitis, resulted in more decreases in GPX and more increases in NO compared to group P. Conclusion: Although any additive effect of cholesterol-enriched diet to ABL was not found in rats with ligature-induced experimental periodontitis, these findings revealed that a cholesterol-enriched diet could lead to ABL and an increase in periodontal inflammation and serum pro-oxidants.

Amaç: Psikososyal faktörler periodontal hastalık için önemli bir risk faktörüolarak tanımlanır, konak direncini değiştirerek ve endokrin dengesizliklereneden olarak periodontal dokuları etkileyebilir. Bu çalışmada algılanan stresinve strese bağlı hormon düzeyiyle periodontal durum arasındaki ilişkisinindeğerlendirilmesi amaçlanmıştır.Gereç ve Yöntem: Bu çalışmaya 42 gingivitisli ve 30 periodontal olarak sağlıklı, toplam 72birey dahil edildi. Hastaların klinik ve radyolojik periodontal değerlendirmesiyapıldı. Stres düzeyleri tükürük kortizol seviyesi ve Cohen Algılanan StresÖlçeği (ASÖ-10) değerleri kullanılarak incelendi. Bireylerin tükürüktekikortizol seviyesi ELİSA yöntemi kullanılarak ölçüldü. Elde edilen verilerp0.05). Salivary cortisol level and PSS-10 scores inperiodontal healthy subjects were lower than subjects with gingivitis (p

Amaç: Bu çalışmanın amacı Konya ilindeki devlet okullarında okuyan, 14-18 yaş grubu lise çağındaki genç bireylerde Periodontitis prevelansını araştırmak ve bu bireylerin periodontal tedavi gereksinimlerini belirlemektir. Gereç ve yöntem: Toplam 362 lise öğrencisi (174 kız ve 188 erkek) çalışmaya dahil edildi. Tüm öğrenciler kendi okullarında gün ışığında, Dünya Sağlık Örgütü (WHO)’nun periodontal sondu ve ayna kullanılarak muayene edildi. Periodontal tedavi gereksinimi, Toplum Periodontal Tedavi Gereksinimi İndeksi “Community Periodontal Index of Treatment Needs” (CPITN) kodlamasına göre belirlendi. Bulgular: Muayene edilen toplam 362 öğrenci içerisinden üç öğrenciye (1 kız ve 2 erkek) periodontitis teşhisi konuldu. Toplam 2172 sekstant incelendi ve 1220 sekstantın (% 56.17) sadece ağız hijyeni eğitimi gereksinimi, 889 sekstantın (% 40.93) diştaşı temizliği gereksinimi ve 5 sekstantın da (% 0.23) diştaşı temizliğine ilave olarak ileri periodontal tedavi gereksinimi olduğu belirlendi. Sonuç: Bu çalışmanın limitleri dahilinde Konya ilinde lise çağındaki öğrencilerde periodontitis prevelansının % 0.83 ve kız/erkek oranının 1:2 olduğu tespit edildi. Muayene edilen toplam 2172 sekstantta sadece 58 sekstantın (% 2.67) tedaviye gereksiniminin olmadığı belirlendi., Background: The aim of this study was to investigate the prevalence of periodontitis among school students aged 14 to 18 years in Konya city and determine the periodontal treatment needs. Methods: A total of 362 students (174 females and 188 males) selected from 12 public schools participated in the study. The subjects were interviewed and examined clinically at their schools with sunlight access. Their mouths were coded according to the recommendations of the Community Periodontal Index of Treatment Needs (CPITN) using a mirror and a World Health Organization 621 ball-tip probe. Results: 362 students were screened and 3 (one female and two males) were diagnosed with periodontitis. Total of 2172 sextants were examined and determined that 1220 (56.17 %) required oral hygiene motivation only, 889 (40.93 %) required scaling, and 5 (0.23 %) required scaling and further complex periodontal treatment. Conclusion: Within the limits of this study, the prevalence of periodontitis was 0.83 % in the public school students in Konya with a female/male ratio of 1:2. Among the 2172 sextants, only 58 (2.67 %) did not require periodontal treatment.

Introduction: The aim of this study was to assess the impact of oral health-related quality of life in elderly patients with periodontal disease. Materials and Method: In total, 110 elderly patients (age range 65 to 92) were included in this study. The Geriatric Oral Health Assessment Index questionnaire was used to determine the perceived oral health-related quality of life of the participants. Gingival index, plaque index, clinical attachment level, probing pocket depth, and bleeding on probing measurements were performed to determine the periodontal status. Results: The total Geriatric Oral Health Assessment Index score was significantly higher among elderly patients with severe periodontitis (25.69±6.80) than among those with gingivitis (21.35±7.01). Higher scores indicate a poorer oral health-related quality of life among elders with periodontal disease. Furthermore, this score was significantly associated with gingival recession, mobile teeth, and oral malodor (p

WOS:000439889600001 PubMed: 30043934 Objectives: The purpose of this study was to determine the impact of non-surgical periodontal therapy considering the salivary stress-related hormone and cytokine levels in the gingival crevicular fluid (GCF) on pregnant and non-pregnant women. Material and Methods: Thirty non-pregnant (control group) and 30 pregnant women (test group) that met the study inclusion criteria were chosen. Only participants with gingivitis were included. Clinical data and samples of GCF and saliva were collected at baseline and after periodontal therapy. The levels of interleukin-1 beta (IL-1 beta and IL-10, and concentration of salivary chromogranin A (CgA) hormone were analyzed by enzyme-linked immunosorbent assay (ELISA). The repeated measures analysis of variance was used for intragroup and intergroup analyses. Results: A major decrease in the gingival inflammation was observed in both groups after periodontal therapy (p0.05). Conclusions: Within the limitations of this study, periodontal therapy significantly improved the periodontal status and stress level. In addition, the severity of the gingival inflammation during pregnancy was related to stress. However, further studies will be needed to substantiate these early findings.

Psikolojik stres; ailesel problemler, maddi sorunlar veya sevdiği birini kaybetme gibi kişinin hayatında karşı karşıya geldiği olaylarla başa çıkması gerekirken, bunu yapamadığında yaşadığı duygu ve fizyolojik reaksiyonlardır. Stres ve depresyonun, genetik ve çevresel faktörlerle etkile- şimi gibi moleküler ve hücresel anormalliklerden kaynaklandığı düşünülmektedir. Kronik psikososyal stres, hastalığın seyrini ve sonucunu etkilemesinin yanı sıra kardiyovasküler hastalık, diyabet gibi sistemik durumların riskini artırmaktadır. Stres, periferik korteks ve hipokampus dâhil olmak üzere limbik beyin bölgelerinin fonksiyon kaybı ve atrofisi ile ilişkilidir. Kronik stres dolaşımdaki proinflamatuar sitokinleri artırarak, vasküler inflamasyonun uyarılması ile sonuçlanmaktadır. Stres ve depresyonun immün sistem fonksiyonunu azalttığı ve kronik inflamasyona neden olduğu vurgulanmaktadır. İnsandaki stresi değerlendirmek için tükürük belirteçlerinin kullanımı son 30 yıl içinde daha fazla önem kazanmıştır. Tükürük kolaylıkla toplanabilen, lokal ve sistemik periodontal hastalık belirteçlerini içeren bir sıvıdır ve özellikle depresyon gibi stres koşullarını değerlendirmek için iyi bir materyal olarak düşünülmektedir. Klinik çalışmalarda, periodontit ve psikolojik stres arasındaki olası ilişki araştırılmış ve bir biyolojik etki mekanizması ile bir davranışsal etki mekanizması olduğu gösterilmiştir. Çoğu çalışmada psikolojik stres periodontitisle ilişkili bulunmuş- tur. Psikolojik kaynaklı oluşmuş böyle bir ilişkiden immün sistemin etkilenmesi sorumludur. Psikososyal stres, periodontal hastalıkların etiyolojisinde, ilerlemesinde ve tedavi sonuçlarında önemli bir rol oynamaktadır. Bu çalışmada, stresin tükürük stres hormonlarının değişimi ile birlikte periodontal durumla ilişkisi, inflamatuar hastalıkların patofizyolojisinde nöroendokrin ve nöroimmün mediyatörlerin rolüne değinilecektir. Psychological stress is the emotional and physiological reactions experienced when a person is unable to do so in the life of a person, such as a marriage conflict, financial debt, or the loss of a loved one. Stress and depression are thought to originate from molecular and cellular ab- normalities such as interaction with genetic and environmental factors. Chronic psychosocial stress increases the risk of systemic conditions such as cardiovascular disease and diabetes as well as af- fecting the course and the outcome of the disease. Stress is associated with loss of function and at- rophy of limbic brain regions including peripheral cortex and hippocampus. Chronic stress stimulates vascular inflammation by increasing circulating proinflammatory cytokines. It is emphasized that stress and depression reduce the function of the immune system and cause chronic inflammation. The use of saliva markers to assess internal stress has become more important over the past 30 years. Saliva is a fluid that can be collected easily, including local and systemic peri- odontal disease markers, and is considered as a good material to evaluate stress conditions, especially depression. The possible relationship between periodontitis and psychological stress has been in- vestigated in clinical trials and it has been shown that there is a mechanism of biological action and a behavioral effect mechanism. Psychological stress has been associated with periodontitis in most studies. It is the responsibility of the affected immune system to be influenced by psychological origin. Psychosocial stress plays an important role in the etiology, progression and outcome of pe- riodontal diseases. In this review article, we will discuss the role of neuroendocrine and neuroim- mune mediators in the pathophysiology of inflammatory diseases, as well as the relationship between stress and the change of salivary stress hormones

Objectives: Helicobacter pylori (H.Pylori) is a Gram(-), microaerophilic bacteria and the etiological factor of chronic activegastritis and peptic ulcer. Some studies indicated that this bacterium found atoral cavity which is a potential reservoir for stomach. Several studies showedthat H. pylori may found in salivaand subgingival plaque of chronic periodontitis patients. However, there is nodata related to aggressive periodontitis patients. In this study, we aimed todetermine the prevalence of H. pyloriin subgingival plaque samples of chronic, aggressive periodontitis andgingivitis patients and to increase the awareness of the patients for gastricproblems. Materialsand Methods: This study included 155 patients (61 with gingivitis,60 with chronic periodontitis, and 34 with aggressive periodontitis) who didnot have gastric disease symptom and did not use antibiotics in the last 3months. The subgingival plaque samples were taken using sterile paper points.The existence of H. pylori, A. actinomycetemcomitans,and P. gingivaliswas detected by RT-PCR. Results: H. pylori was not detected in any groupsat the end of microbiological analysis.However, a high occurrence of A. actinomycetemcomitans (97.1%) and P. gingivalis(100%) was observed in the aggressive periodontitis group. However, A. actinomycetemcomitansand P. gingivalis were found in 30% and 21.7% of patients,respectively, with chronic periodontitis. A.actinomycetemcomitans and P. gingivaliswere found in 24.6% of patients in the gingivitis group.Conclusions: H. pylori were not detected in samples, indicating that subgingival plaque may notbe a primary reservoir for this bacterium., Amaç: Helicobacter pylori (H. Pylori),bir gram (-), mikroaerofilik bakteri olup, kronik aktif gastrit ve peptikülserin etyolojik faktörüdür. Bazı çalışmalar, bu bakterinin, oral kavitedebulunduğunda, mide için potansiyel rezervuar olabileceğini göstermiştir. Çeşitliçalışmalar, H. pylori'nin kronik periodontitisli hastaların tükrük vesubgingival plaklarında görülebileceğini göstermiştir. Bununla birlikte agresifperiodontitis hastaları ile ilgili herhangi bir veri yoktur. Bu çalışmada, kronik, agresifperiodontitis ve gingivitis hastalarının subgingival plak örneklerinde H.pylori prevalansını saptamayı ve hastaların gastrik problemler konusundabilinçlenmesini arttırmayı amaçladık.Gereçve Yöntem: Bu çalışma,gastrik hastalık semptomu olmayan ve son 3 ayda antibiyotik kullanmayan 155hasta (61 adet gingivitis, 60'ı kronik periodontitisli ve 34 agresifperiodontitisli) içermekteydi. Subgingivalplak örnekleri steril paper point kullanılarak alındı. H.pylori, A. actinomycetemcomitans ve P. gingivalis'in varlığı RT-PCR ile tespitedildi.Bulgular: Mikrobiyolojikanalizin sonunda herhangi bir grupta H. pylori tespit edilmedi. Bununla birlikte, agresif periodontit grubunda yüksekoranda A. actinomycetemcomitans (%97.1) ve P. gingivalis (%100) görülmüştür. Bununla birlikte, A.actinomycetemcomitans ve P. gingivalis, kronik periodontitisli hastalarınsırasıyla %30 ve %21.7'sinde bulunmuştur. A. actinomycetemcomitans ve P.gingivalis gingivitisli hastaların %24.6'sında bulundu. Sonuç: H. pylori, örneklerde saptanmamışolması, subgingival plağın bu bakteri için birincil rezervuar olmayabileceğinigösterdi.

The aim of this study was to evaluate the effects of melatonin on the oxidative stress in heart tissues after induction of experimental periodontitis in rats. Thirty Wistar Albino male rats were divided into four groups as follows: healthy + saline solution (Hs, n = 7), healthy + melatonin (Hm, n = 7), periodontitis + saline solution (Ps, n = 8), and periodontitis + melatonin (Pm, n = 8). Experimental periodontitis was induced using a ligature placed at the gingival margin of the maxillary second molars. Melatonin was applied intraperitoneally (10 mg/ kg) every day for 2 weeks. After sacrificing the rats, serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) levels, and melatonin levels were evaluated. The Pm group exhibited lower alveolar bone loss than the Ps group. Melatonin levels increased in the periodontitis groups, and the Pm group had lower MDA levels and higher GSH-Px levels than the Ps group. These findings suggest that melatonin administration reduces MDA and increases GSH-Px levels in heart tissue, and these effects may be due to its antioxidant properties. Further studies are needed to understand the effects of melatonin on the association between periodontitis and cardiovascular disease. © 2017, Nihon University, School of Dentistry. All rights reserved., 1853-D-09, This study was supported by the Scientific Research Foundation of S?leyman Demirel University (Number: 1853-D-09).

WOS:000404096500013 PubMed: 28637984 The effects of systemically administered rosuvastatin on alveolar bone loss (ABL), cytokine levels and oxidative status were investigated in rats with ligature-induced periodontitis. Rats were divided randomly into four groups: a non-ligated group (C); a non-ligated+rosuvastatin group (R); a ligated group (P); and a ligated+rosuvastatin group (PR). Ligatures were placed at the maxillary second molars, and rosuvastatin was administered for 14 days. After the rats had been euthanatized, histomorphometric and histological analyses were performed, and the serum levels of interleukin (IL)-10, IL-10 and oxidant and antioxidant parameters (malondialdehyde [MDA], superoxide dismutase, glutathione, and glutathione peroxidase) were evaluted by enzyme-linked immunosorbent assay. Rosuvastatin significantly decreased the extent of ABL, inflammatory infiltration and osteoclasts in periodontitis, but increased the numbers of osteoblasts. Although rosuvastatin reduced the levels of IL-1 beta, they did not differ significantly between the PR and P groups. In the PR group, not only were IL-10 levels significantly higher but also the ratio of IL-1 beta to IL-10 was lower than in the P group. Although MDA levels were significantly increased in the P group relative to the C group, they did not differ significantly between the PR and C groups. The present data suggest that rosuvastatin decreases ABL in ligature-induced periodontitis, and that its anti-inflammatory effect is more remarkable than its antioxidant effect.

Amaç: Bu çalışmada agresif periodontitis (AP) hastalarının dişeti oluğu sıvısı (DOS) hacim değerlerinin belirlenmesi ve periodontal yıkım derecesinin DOS hacmi üzerine olan etkisinin değerlendirilmesi amaçlandı. Gereç ve Yöntemler: Bu kesitsel çalışma Selçuk Üniversitesi, Diş hekimliği Fakültesi, Periodontoloji bölümünde yürütüldü. Araştırmaya 80 AP ve yaş ve cinsiyet olarak eşleştirilmiş 80 periodontal olarak sağlıklı (S) olmak üzere toplam 160 birey dahil edildi. Hastalardan klinik olarak plak indeksi (Pİ), gingival indeks (Gİ), sondlama cep derinliği (SCD) ve klinik ataşman kaybı (KAK) değerleri kaydedildi. Çalışmaya dahil edilen 50 lokalize (L) AP, 30 generalize (G) AP ve 80 S olmak üzere toplam 160 bireyden DOS alındı. Elde edilen DOS hacim değerleri elektronik hacim ölçücü Periotron ile değerlendirildi (Periotron 8000, OroFlow Inc.). Bulgular: S kontrollerle kıyaslandığında tüm klinik parametreler LAP ve GAP hastalarında anlamlı derecede yüksekti (p0.05). Sonuç: DOS hacim değerleri örneklemenin yapılmasından analiz edilinceye kadarki süreçte birçok faktör tarafından etkilenebilir. Bu nedenle araştırmacıların DOS hacim değerlerinin belirlenmesinde çok dikkatli olmaları gerekmektedir. Bu araştırmanın sınırları dahilinde periodontal yıkım derecesinin DOS hacim değerlerini etkilemediği sonucuna varılabilir., Background: The present study aimed to determine the gingival crevicular fluid (GCF) volume of Aggressive periodontitis patients and to detect whether the degree of destruction effects the volume of GCF. Methods: This cross-sectional study was carried out at Selcuk University, Faculty of Dentistry, Department of Periodontology. A total of 160 subjects including, 80 Aggressive periodontitis (AP) and 80 age and gender matched periodontally healthy (H) controls were recruited. Clinical periodontal measurements including plaque index (PI), gingival index (GI), proping depth (PD) and clinical attachment loss (CAL) were performed. GCF samples were collected from 160 patients including 50 localized (L) AP, 30 generalized (G) AP and 80 H. Volume of GCF samples were measured by an electronic device (Periotron 8000, OroFlow Inc.). Results: Compared to H controls, all clinical parameters were significantly higher in subjects with LAP and GAP (p0.05). Conclusion: GCF volume can be affected by several factors from sampling to analysing. For this reason researchers have to be careful in determining the volume measurements of GCF. In the limit of this study we may speculate that the degree of periodontal destruction may not effect the GCF volume in patients with GAP.

Amaç: Bu çalışmanın amacı obez ve morbid obez hastaların tükürük pHsı tamponlama kapasitesi ve DMF-T indeks değerlerini sağlıklı bireylerle karşılaştırmaktır. Gereç ve yöntem: Çalışmaya vücut kütle indeksi (VKİ) (Body Mass Index) ≥30 olan ve yaş ortalaması 45.6 olan 34 obez bayan ile, VKİsı 19-25 olan ve yaş ortalaması 41 olan 12 sağlıklı bayan gönüllü olarak katıldı. Obez gruptaki bireyler ayrıca 15 birey obez (VKİ 0.05). Conclusion: As a result of this study, it was suggested that obesity could not influence the salivary pH, buffering capacity and caries indices.