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Objective: To evaluate the demographic profile, clinical severity, and outcome of Covid‑19 infection in hospitalised vaccinated individuals. Methods: An observational, cross‑sectional study was conducted among Covid‑19 infected hospitalised patients. Clinicodemographic profile, severity, and outcome of Covid‑19 infection among the vaccinated group (VG) were recorded. These patients were also compared with unvaccinated group (UVG) with Covid‑19 infection admitted during the study period. Cox proportional hazards models was used to estimate hazard ratios for mortality risk in both groups. Results: Out of 580 participants, 48.2% were vaccinated with either one (71%) or two doses (28.9%). In both, VG and UVG, majority 55.8% belonged to 51–75 years. Males were predominant with 62.9% in both VG and UVGs. Day of illness at admission from symptom onset (DOI), progression of disease, ICU stay, oxygen requirement, mortality was significantly higher in UVG than in VG (p < 0.05). Steroid duration (p < 0.001) and anti‑coagulation time (p < 0.001) were significantly higher in UVG than in VG. D dimer levels were significantly higher in UVG than in VG (p < 0.05). Increased age, (p < 0.0004), severity of disease, (p < 0.0052), increased oxygen requirement (p < 0.001), elevated C‑reactive protein levels (Moderate: P < 0.0013; Severe P < 0.0082), and elevated IL‑6 levels (p < 0.001) were the significant determinants of Covid‑19‑related mortality in both VG and UVGs. Conclusion: Vaccinated individuals have shown milder severity, had reduced hospital stay and better outcomes as compared to unvaccinated individuals suggesting a potential vaccine efficacy against Covid‑19. [ABSTRACT FROM AUTHOR]