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Groundwater contamination is a major problem related strongly to both; protection of environment and the need of water. In the present study groundwater quality was investigated in the central part of the Nile Delta (El-Gharbiya Governorate). El-Gharbiya Governorate is an agricultural land and its densely populated area inhabited, includes small communities which totally not served by public sewers. Hydrochemical analyses were used to assess the quality of water in samples taken from the canals, drains and groundwater. A laboratory study and mathematical modeling works were presented. Two numerical computer models by the applying of finite difference method were adopted. Both models deal with the flow as a three-dimensional and unsteady. Results obtained include determining the levels of water and the values of solute concentration and distribution of it in the region at different times. The groundwater model MODFLOW was used to deal with the hydrodynamics of the flow through porous media. A solute transport model which can be communicated with MODFLOW through data files MT3DMS, was used to solve the problem of contaminants transport and the change of their concentrations with time. A proposed groundwater remediation scheme by using group of extraction wells was suggested at Birma region where the concentration values of ammonium contaminant are the up most according to hydrochemical analyses results. Proposed scenario for cleaning is to use a set of wells to pump contaminated groundwater extraction for treatment and reused to irrigation.