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Measurements of the elastic scattering angular distribution for the d+$^{197}$Au system were carried out covering deuteron incident energies in the range from 5 to 16 MeV, i.e. approximately 50% below and above the Coulomb barrier. A critical interaction distance of $d_I$= 2.49 fm was determined from these distributions, which is comparable to that of the radioactive halo nucleus $^{6}$He. The experimental angular distributions were systematically analyzed using two alternative models: the semi-microscopic Sao Paulo and the effective Woods-Saxon optical potentials, for which the best-fitting parameters were determined. These potentials, integrated in the vicinity of the sensitivity radius, were calculated for each energy. For both models, the energy dependence of these integrals presented the breakup threshold anomaly around the coulomb barrier, a typical signature of weakly bound nuclei., Comment: 20 pages. 7 figures. 60 References

In this work, one-neutron transfer (pickup and stripping), complete and incomplete fusion cross sections for the $^{9}\mathrm{Be}+^{197}\mathrm{Au}$ system were measured over a wide range of energies around the Coulomb barrier by the offline $\ensuremath{\gamma}$-ray detection method. Coupled-channel calculations were used to determine the elastic, inelastic, and transfer cross sections. Coupled reaction channel calculations were performed to derive the one-neutron stripping and pickup cross sections. Three-body continuum discretized coupled-channel calculations were used to determine the effect of the breakup channel on the other reaction mechanisms. The reduced complete and total fusion were found to be hindered above and enhanced below the Coulomb barrier compared with the universal fusion function due to the breakup plus transfer effects.

Changes in oral health status following treatment should be assessed clinically as well as by patients’ reported outcomes. This study investigated changes on oral-health-related quality of life (OHRQoL) of adolescents enrolled in a comprehensive oral health care program for caries and gingival conditions. The sensitivity of the Child Perception Questionnaire11–14 (CPQ11–14) to detect clinical changes, that is, its responsiveness, was assessed. A total of 618 10–15-year adolescents answered the questionnaire before treatment and 560 at follow-up after 1 year. In the follow-up, 2 additional global transition judgment questions were asked. The adolescents were clinically and radiographically examined. At the baseline, 374 adolescents needed only nonoperative treatment, whereas 274 needed non- and operative treatments. After 1 year, the adolescents were regrouped according to the fulfillment of their treatment needs in Group 1 (n = 363) needing/receiving nonoperative treatment only; Group 2 (n = 98) needing/receiving both non- and operative treatments; Group 3 (n = 99) receiving nonoperative treatment only, while needing also operative treatment. The CPQ11–14 total mean change scores by the global transition judgment on self-perceived oral health status indicated significant differences (p < 0.001, ANOVA; internal responsiveness). The effect of the program for the treatment groups was significant (p = 0.014, ANCOVA; external responsiveness). The effect size for the change scores was of moderate magnitude. In conclusion, an overall improvement of adolescents’ OHRQoL was observed following 1-year oral health care program for caries and gingival conditions. The CPQ11–14 was internally and externally sensitive to detect substantial clinical changes. The CPQ11–14 seems appropriate for measuring long-term changes on adolescents’ OHRQoL.

This study was supported by grants FIS PI17/0393 and PI20/0318 from the Spanish Ministry of Science and Innovation (Instituto de Salud Carlos III); grants PI-0257-2017 and PE-0395- 2019 from Consejería de Salud y Familias, Junta de Andalucía, España; grant P18-RT-5059 from Consejería de Economía, Conocimiento, Empresas y Universidad, Junta de Andalucía, España; grant A-CTS-498-UGR18 from the University of Granada and Junta de Andalucía, España. It was co-funded by FEDER-ERDF funds., Authors are grateful to Fabiola Bermejo Casares for the technical histological assistance. Special thanks to Ariane Ruyffelaert for her critical review and proofreading service. This work forms part of the doctoral thesis conducted by David Sánchez Porras (Doctoral Program in Biomedicine, Doctoral School, University of Granada, Spain)., Considering the high prevalence of cartilage-associated pathologies, low self-repair capacity and limitations of current repair techniques, tissue engineering (TE) strategies have emerged as a promising alternative in this field. Three-dimensional culture techniques have gained attention in recent years, showing their ability to provide the most biomimetic environment for the cells under culture conditions, enabling the cells to fabricate natural, 3D functional microtissues (MTs). In this sense, the aim of this study was to generate, characterize and compare scaffold-free human hyaline and elastic cartilage-derived MTs (HC-MTs and EC-MTs, respectively) under expansion (EM) and chondrogenic media (CM). MTs were generated by using agarose microchips and evaluated ex vivo for 28 days. The MTs generated were subjected to morphometric assessment and cell viability, metabolic activity and histological analyses. Results suggest that the use of CM improves the biomimicry of the MTs obtained in terms of morphology, viability and extracellular matrix (ECM) synthesis with respect to the use of EM. Moreover, the overall results indicate a faster and more sensitive response of the EC-derived cells to the use of CM as compared to HC chondrocytes. Finally, future preclinical in vivo studies are still needed to determine the potential clinical usefulness of these novel advanced therapy products., Instituto de Salud Carlos III Spanish Government FIS PI17/0393 PI20/0318, Junta de Andalucia PI-0257-2017 PE-03952019, Junta de Andalucia P18-RT-5059, University of Granada A-CTS-498-UGR18, Junta de Andalucia A-CTS-498-UGR18, FEDER-ERDF funds

Gamma-ray angular distributions in oriented $$^{92}$$ Mo produced via the $$^{6}$$ Li+ $$^{89}$$ Y reaction were studied in this work. The characteristic $$\gamma $$ rays in $$^{92}$$ Mo were measured by means of the GALILEO array, which is composed of 25 Compton-suppressed HPGe detectors arranged in a nearly 2 $$\pi $$ geometry. A detailed analysis of the spin-alignment attenuation factors ( $$\alpha _2$$ ) for different excited states in $$^{92}$$ Mo was performed, by analyzing the measured angular distribution coefficients of several pure-E2 transitions. The relationship between $$\alpha _2$$ and the spin was established in $$^{92}$$ Mo and the 244-keV transition between the 5 $$^-_1$$ and 4 $$^+_1$$ states resulted to have a E1 + M2 character with a mixing ratio ( $$\delta $$ ) of $$-0.05^{+0.05}_{-0.06}$$ , consistent with shell model calculations.

The role of sex in cardiovascular physiology has been extensively studied and has a great impact on the pathophysiology of cardiovascular diseases (CVD). In the last years, epigenetic regulation of gene expression has been established as a new mechanism for the correct cardiovascular homeostasis, involving both sex chromosomes and sex hormones. A number of epigenetic modifiers are encoded on sex chromosomes, which can induce sex differences in somatic gene expression independently of hormonal differences. Otherwise, sex hormones are transcriptional regulators in their own right by acting as ligands for nuclear hormone receptors and therefore providing the phenotype of sex-associated gene expression. Thus, this chapter summarizes epigenetic mechanisms concerning CVD, in particular DNA methylation, histone modifications, and noncoding RNA related to sex chromosomes and sex hormones. We conclude that epigenetic mechanisms can also modulate the differential gene expression between men and women, contributing to the marked sex differences found in CVD. However, our understanding of sex differences at the molecular level is limited due to the scarcity of sex stratification in preclinical and translational cardiovascular epigenetics. An adjustment to our approaches needs to be made to gain a more detailed understanding of sex differences, necessary to discover new sex-specific downstream nodes in classical signaling pathways.

International audience; Cardiovascular disease (CVD) is the biggest cause of sickness and mortality worldwide in both males and females. Clinical statistics demonstrate clear sex differences in risk, prevalence, mortality rates, and response to treatment for different entities of CVD. The reason for this remains poorly understood. Non-coding RNAs (ncRNAs) are emerging as key mediators and biomarkers of CVD. Similarly, current knowledge on differential regulation, expression, and pathology-associated function of ncRNAs between sexes is minimal. Here, we provide a state-of-the-art overview of what is known on sex differences in ncRNA research in CVD as well as discussing the contributing biological factors to this sex dimorphism including genetic and epigenetic factors and sex hormone regulation of transcription. We then focus on the experimental models of CVD and their use in translational ncRNA research in the cardiovascular field. In particular, we want to highlight the importance of considering sex of the cellular and pre-clinical models in clinical studies in ncRNA research and to carefully consider the appropriate experimental models most applicable to human patient populations. Moreover, we aim to identify sex-specific targets for treatment and diagnosis for the biggest socioeconomic health problem globally.

Over the last few years, there has been a substantial increase in the degree of complexity of requirements regarding the licensing of tailings dams in Brazil. The stacking of filtered tailings is currently proposed as an alternative solution for tailings storage facilities; however, there are numerous challenges to understand and manage these structures in regions of high rainfall and high disposal rates. In this context, the objective of this article is to evaluate the liquefaction susceptibility of filtered iron ore tailings, based on field (piezocone) and laboratory tests (characterization and triaxial compression), both performed at an experimental landfill, located in the Iron Quadrangle (Quadrilatero Ferrifero), Minas Gerais state, Brazil. Therefore, a few methodologies were used to evaluate liquefaction susceptibility by means of the critical state theory, furthermore the fragility index of the material were also evaluated. Results indicated that the constructive method used in the experimental landfill (i.e., compaction energy, moisture and layer thickness) resulted in variability in the in-situ void ratio, indicating susceptibility to liquefaction for materials on depths greater than 0.75 m from compaction surface. In addition, from laboratory tests it was possible to determine the critical state line of the filtered tailings.

Females live longer than males. This could be in part due to the higher levels of estrogens in females, which protect them against aging. Physiological concentrations of estrogens have antioxidant effects as they induce the expression of manganese superoxide dismutase and glutathione peroxidase by stimulating estrogen receptors and the mitogen-activated protein kinase and nuclear factor kappa B pathways. However, estrogens can have undesirable effects such as they are feminizing to males, so other alternatives need to be searched. Phytoestrogens are good candidates as they can also bind to estrogens receptors, and in fact, they are able to mimic the antioxidant properties of estrogens. It is very important to consider that the expression of estrogen receptors is not the same between sexes, organs or that their proportion changes with age. Depending on the organ studied, there are differences in the estrogen receptors involved in the beneficial effects of estrogens.

The precise quasielastic excitation function for the $^{18}\mathrm{O}+^{64}\mathrm{Zn}$ system was measured at energies near and below the Coulomb barrier at ${\ensuremath{\theta}}_{\mathrm{lab}}={161}^{\ensuremath{\circ}}$, from which its correlated quasielastic barrier distribution was derived. The excitation functions for the two-neutron, $\ensuremath{\alpha}$, and tritium transfer reactions have also been measured at the same conditions. These data were well described by the coupled channel and coupled reaction channel calculations. The comparison of the data with theoretical calculations shows the strong influence of three inelastic channels in the coupling process: the quadrupole and octupole vibrational states of $^{64}\mathrm{Zn}$, ${2}_{1}^{+}$ and ${3}_{1}^{\ensuremath{-}}$, and the quadrupole vibrational state of $^{18}\mathrm{O}$, ${2}_{1}^{+}$. In addition, theoretical calculations indicate that the two-neutron stripping is mostly due to a one-step process, which has a striking effect on the reaction mechanism of this system.

Elastic scattering and transfer cross sections for the $^{7}\mathrm{Be}+^{9}\mathrm{Be}$ system have been measured at ${E}_{\mathrm{lab}}=23.1\phantom{\rule{0.28em}{0ex}}\mathrm{MeV}$ using the $^{7}\mathrm{Be}$ radioactive secondary beam produced at Radioactive Ion Beams in Brazil facility at the University of S\~ao Paulo. The elastic scattering has been measured by detecting the $^{7}\mathrm{Be}$ scattered at forward angles in the laboratory system. The transfer reaction $^{9}\mathrm{Be}(^{7}\mathrm{Be},^{9}\mathrm{Be})^{7}\mathrm{Be}$ was identified by detecting the $^{9}\mathrm{Be}$ scattered at the same laboratory angles. The elastic angular distribution has been analyzed by optical model calculations using a Woods-Saxon form factor whose parameters have been varied to best reproduce the experimental data at forward angles. Coupled reaction channels calculations (CRC) have been performed to describe the transfer, considering the coupling to the transfer channel and including contributions to the ground state and to the first excited state of $^{7}\mathrm{Be}(1/2\ensuremath{-};429\phantom{\rule{0.16em}{0ex}}\mathrm{keV}$) in the final state. The spectroscopic amplitudes used in the CRC calculation have been derived from shell-model calculations. Similar CRC calculations were applied to existing $^{9}\mathrm{Be}(p,t)^{7}\mathrm{Be}$ data to check the consistency of our results results for the ($^{7}\mathrm{Be},^{9}\mathrm{Be}$) transfer reaction.

In this work, we study the effect of paring correlation on the two-neutron transfer reaction \(^{28}\)Si(\(^{18}\)O,\(^{16}\)O)\(^{30}\)Si at 84 MeV incident energy in the laboratory frame. For this, coupled reaction channel (CRC) and coupled channel Born approximation (CCBA) calculations were performed considering the cluster, independent coordinates and sequential transfer models for two-neutron transfer. For the calculation of the spectroscopic amplitudes the NuShellX (http://www.garsington.eclipse.co.uk/, [1]) code was used.

Background: Recently, a systematic exploration of two-neutron transfer induced by the $(^{18}\mathrm{O},\phantom{\rule{0.16em}{0ex}}^{16}\mathrm{O})$ reaction on different targets has been performed. The high-resolution data have been collected at the MAGNEX magnetic spectrometer of the INFN-LNS Laboratory in Catania and analyzed with the coupled reaction channel (CRC) approach. The simultaneous and sequential transfers of the two neutrons have been considered under the same theoretical framework without the need for adjustable factors in the calculations.Purpose: A detailed analysis of the one-neutron transfer cross sections is important to study the sequential two-neutron transfer. Here, we examine the $(^{18}\mathrm{O},\phantom{\rule{0.16em}{0ex}}^{17}\mathrm{O})$ reaction on $^{16}\mathrm{O},\phantom{\rule{0.28em}{0ex}}^{28}\mathrm{Si}$, and $^{64}\mathrm{Ni}$ targets. These even-even nuclei allow for investigation of one-neutron transfer in distinct nuclear shell spaces.Method: The MAGNEX spectrometer was used to measure mass spectra of ejectiles and extract differential cross sections of one-neutron transfer to low-lying states. We adopted the same CRC formalism used in the sequential two-neutron transfer, including relevant channels and using spectroscopic amplitudes obtained from shell-model calculations. We also compare with the one-step distorted-wave Born approximation (DWBA).Results: For the $^{18}\mathrm{O}+^{16}\mathrm{O}$ and the $^{18}\mathrm{O}+^{28}\mathrm{O}$ systems, we used two interactions in the shell model. The experimental angular distributions are reasonably well reproduced by the CRC calculations. In the $^{18}\mathrm{O}+^{64}\mathrm{Ni}$ system, we considered only one interaction, and the theoretical curve describes the shape and order of magnitude observed in the experimental data.Conclusions: Comparisons between experimental DWBA and CRC angle-integrated cross sections suggest that excitations before or after the transfer of a neutron are relevant in the $^{18}\mathrm{O}+^{16}\mathrm{O}$ and $^{18}\mathrm{O}+^{64}\mathrm{Ni}$ systems.

A precise quasielastic excitation function for the $^{18}\mathrm{O}+^{63}\mathrm{Cu}$ system has been measured at energies around the Coulomb barrier at ${\ensuremath{\theta}}_{\mathrm{LAB}}={161}^{\ensuremath{\circ}}$. The corresponding quasielastic barrier distribution has been derived. Two-neutron-, one-proton-, and \ensuremath{\alpha}-transfer-excitation functions have also been measured at the same energies and angle. Coupled reaction channels calculations were performed to describe the experimental data. Large-scale shell-model calculations were performed to derive most of the spectroscopic amplitudes. No surface imaginary potential was necessary for the interaction potential because almost all relevant reaction channels were explicitly included in the calculation. The theoretical results were compared to the experimental quasielastic barrier distribution and a very good agreement was achieved. The comparison of the coupled reaction channel calculations and data has put in evidence several important details of the reaction mechanism of the $^{18}\mathrm{O}+^{63}\mathrm{Cu}$ system. The collectivity of the $^{63}\mathrm{Cu}$ nucleus has important contribution to the reaction mechanism of this system, mainly due to its first $5/{2}^{+}$ and $7/{2}^{+}$ states. It was also observed a striking influence on the reaction dynamics of the $^{18}\mathrm{O}$(${2}^{+}$) state, the two-neutron transfer and the reorientation of the target ground-state spin. The best agreement to data was achieved when the nuclear matter diffuseness for the $^{18}\mathrm{O}$ was assumed equal to 0.60 fm, value that we have derived in a previous paper and that is 10% greater than the $^{16}\mathrm{O}$ diffuseness. Another significant result was that the two-neutron transfer process is much more relevant than the one-neutron-transfer process, which suggests that the pairing correlation could play an important role in the transfer process of this system.

In this paper, we analyze the one-neutron pick-up from the 55Mn target when it is bombarded by 17MeV deuteron, by performing coupled reaction channel (CRC) calculations. Spectroscopic amplitudes for CRC calculations, and structural information such as reduced B(E2) transition probabilities, quadrupole, and magnetic momenta, are obtained from shell-model calculations using the fp-kb3 interaction. The calculated structure quantities are in good agreement with the available experimental data for both target and ejectile. Analyses of angular distributions show the relevance of microscopic information for the description of the higher excited states of 54Mn .

In this work we study the simultaneous and sequential two-neutron transfer mechanisms to the $^{28}\mathrm{Si}$ nucleus induced by $(t,p)$ and $(^{18}\mathrm{O},^{16}\mathrm{O})$ reactions. New experimental cross sections for the $^{28}\mathrm{Si}(^{18}\mathrm{O},^{16}\mathrm{O})^{30}\mathrm{Si}$ reaction at 84 MeV are also presented. Direct reaction calculations are carried out within the exact finite range coupled reaction channel, for the simultaneous transfer of the two-neutron cluster, and the second-order distorted wave Born approximation, for the sequential transfer. Two different models are considered to describe the two-neutron cluster. The spectroscopic information was obtained from a shell-model calculation with a psdmod interaction for the target overlaps where the $1{p}_{3/2}, 1{p}_{1/2}, 1{d}_{3/2}, 1{d}_{5/2}$, and $2{s}_{1/2}$ orbitals are included as valence subspace. We show that simultaneous and sequential two-neutron transfers are competing mechanisms for the population of the ground state in $^{30}\mathrm{Si}$. A systematic analysis of the two-neutron transfer induced by the $(^{18}\mathrm{O},^{16}\mathrm{O})$ reaction indicates that the static deformation of target nuclei impacts the two-neutron transfer mechanism.

The measurement of one-neutron stripping cross sections for the $^{89}\mathrm{Y}(^{6}\mathrm{Li},^{5}\mathrm{Li})^{90}\mathrm{Y}^{*}$ reaction at 22 MeV and 34 MeV is reported, using both in-beam and off-beam $\ensuremath{\gamma}$-ray spectroscopy methods. Characteristic $\ensuremath{\gamma}$ lines of $^{90}\mathrm{Y}$ are clearly identified by both the $\ensuremath{\gamma}\text{\ensuremath{-}}\ensuremath{\gamma}$ and proton-$\ensuremath{\gamma}$ coincidence methods. The obtained cross section of one-neutron stripping at 34 MeV is found to be much smaller than that at 22 MeV. The one-neutron stripping cross sections measured for this system have the same order of magnitude as the one measured for the same reaction for the $^{6}\mathrm{Li}+^{96}\mathrm{Zr}$ system at energies around the Coulomb barrier. Parameter-free coupled reaction channel calculations agree quite well with the experimental data. Theoretical study of the effect of the one-neutron transfer on the elastic total fusion cross section is performed.

We present a brief review of the reaction mechanisms involved in collisions of weakly bound projectiles with tightly bound targets, at near-barrier energies. We discuss systematic behaviors of the data, with emphasis in fusion, breakup, nucleon transfer and elastic scattering. The dependence of the breakup cross section on the charge and mass of the target is discussed, and the influence of the breakup channel on complete fusion is investigated. For this purpose, we compare reduced fusion cross sections with a benchmark universal curve. The behaviors observed in the comparisons are explained in terms of polarization potentials and of nucleon transfer followed by breakup. The influence of the breakup process on elastic scattering is also discussed. Some apparent contradictions between results of different authors are explained and some perspectives of the field are presented.

Recently, various two-neutron transfer studies using the $(^{18}\mathrm{O},^{16}\mathrm{O})$ reaction were performed with a large success. This was achieved because of a combined use of the microscopic quantum description of the reaction mechanism and of the nuclear structure. In the present work we use this methodology to study the two-neutron transfer reaction of the $^{18}\mathrm{O}+^{64}\mathrm{Ni}$ system at 84 MeV incident energy, to the ground and first ${2}^{+}$ excited state of the residual $^{66}\mathrm{Ni}$ nucleus. All the experimental data were measured by the large acceptance MAGNEX spectrometer at the Instituto Nazionale di Fisica Nucleare --Laboratori Nazionali del Sud (Italy). We have performed exact finite range cross section calculations using the coupled channel Born approximation (CCBA) and coupled reaction channel (CRC) method for the sequential and direct two-neutron transfers, respectively. Moreover, this is the first time that the formalism of the microscopic interaction boson model (IBM-2) was applied to a two-neutron transfer reaction. From our results we conclude that for two-neutron transfer to the ground state of $^{66}\mathrm{Ni}$, the direct transfer is the dominant reaction mechanism, whereas for the transfer to the first excited state of $^{66}\mathrm{Ni}$, the sequential process dominates. A competition between long-range and short-range correlations is discussed, in particular, how the use of two different models (Shell model and IBM's) help to disentangle long- and short-range correlations.

We investigate the breakup of the proton halo 8B projectile in the presence of the light target 12C at near barrier energies. Our calculations show that the effect of the breakup on the elastic scattering angular distributions is negligible. We also investigate the relative importance of Coulomb and nuclear breakups for this system. We compare the results of our calculations with those for the 6He + 12C and 8B + 58Ni systems.

Realizou-se esta pesquisa com o objetivo de avaliar as características das madeiras de amburana (Amburana cearencis (Fr. Allem.) A.C. Sm.), bálsamo (Myroxylon peruiferum L.f.), ipê-amarelo (Tabebuia chrysotricha (Mart. ex DC.) Standl.), jatobá (Hymenaea courbaril L. var. stilbocarpa (Hayne) Lee et Lang.) e jequitibá-rosa (Cariniana legalis (Mart.) Kuntze) no armazenamento de cachaças; comparar as cachaças com amostra armazenada em barril de carvalho (Quercus sp.), analisar o efeito do envelhecimento e comparar os valores obtidos com os padronizados pela Legislação Brasileira. Para tanto, as cachaças foram armazenadas em barris de madeira e em recipiente de vidro e analisadas suas características químicas (acidez volátil, álcool metílico, álcool superior, aldeído, cobre, éster, extrato seco a 100 ºC, furfural e grau alcoólico) e organolépticas (cor, sabor e aroma). Após seis meses de armazenamento as cachaças foram comparadas com os valores padronizados. Independente da espécie, a madeira melhorou as qualidades sensoriais da cachaça incorporando, à bebida, cor, gosto e sabor característicos. Todas as cachaças avaliadas continuaram dentro dos padrões de qualidade estabelecidos pela Legislação Brasileira.This research aimed to evaluate the wood quality of Amburana cearencis (Fr. Allem.) A.C. Sm., Myroxylon peruiferum L.f., Tabebuia chrysotricha (Mart. ex DC.) Standl., Hymenaea courbaril L. var. stilbocarpa (Hayne) Lee et Lang. and Cariniana legalis (Mart.) Kuntze in the storage of "cachaça" (Brazilian sugar cane spirit); to compare the "cachaça" studied with the stored one in barrel of oak (Quercus sp.), to analyze the effect of the aging and to compare the values obtained with the standard ones for the Brazilian Legislation. Thus, the "cachaças" were stored in wooden and glass barrels and their chemical (volatile acidity, methyl alcohol, superior alcohol, aldehyde, cupper, ester, dry extract to 100 ºC, furfural contents and alcoholic degree) and organoleptic (color, flavor and aroma) characteristics were analysed. After six months of storage the "cachaças" were compared with the standard values according to Brazilian Legislation. Independent of the species, the wood improves the sensorial qualities of "cachaça", incorporating the drink taste, color and characteristic flavor. All "cachaças" evaluated continued to be with in the standards of quality established by Brazilian Legislation.

The SWAN wave model is widely used in coastal waters and the main focus of this work is on its application in a harbor. Its last released version - SWAN 40.51 - includes an approximation to compute diffraction, however, so far there are few published works that discuss this matter. The performance of the model is therefore investigated in a harbor where reflection and diffraction play a relevant role. To assess its estimates, a phase-resolving Boussinesq wave model is employed as well, together with measurements carried out at a small-scale model of the area behind the breakwater. For irregular, short-crested waves with broad directional spreading, the importance of diffraction is relatively small. On the other hand, reflection of the incident waves is significant, increasing the energy inside the harbor. Nevertheless, the SWAN model does not achieve convergence when it is set to compute diffraction and reflection simultaneously. It is concluded that, for situations typically encountered in harbors, with irregular waves near reflective obstacles, the model should be set without the diffraction option.O modelo de ondas SWAN é amplamente empregado em simulações na região costeira e o presente trabalho investiga sua aplicação dentro de um porto. A última versão disponibilizada para a comunidade - SWAN 40.51 - inclui uma aproximação para computar a difração, embora, até o momento, poucos trabalhos abordando este tema foram publicados. O desempenho do modelo é estudado em um porto onde os fenômenos de reflexão e difração são importantes. Para avaliar suas estimativas, um modelo do tipo Boussinesq também é empregado, juntamente com medições realizadas em um modelo em escala reduzida da área atrás do quebramar. Para ondas irregulares, com cristas curtas e espalhamento direcional mais amplo, a importância da difração é relativamente menor. Contudo, o modelo SWAN não alcança convergência quando programado para estimar difração e reflexão simultaneamente. Conclui-se que, para situações normalmente encontradas em portos, com ondas irregulares próximas a obstáculos refletivos, o modelo deve ser empregado sem a opção de difração.

Fusion, breakup and scattering for the 9Be + 144Sm system at near barrier energies are investigated by different approaches. We show that at energies above the barrier there is a small complete fusion suppression when compared with predictions from a double folding potential and with a similar tightly bound system. At sub-barrier energies there is no significant deviation from the predictions using coupled channel calculations that do not include the breakup channel. The energy dependence of the optical potential does not show the usual threshold anomaly found in tightly bound systems. From a simultaneous analysis of fusion and scattering data we estimate the distance where breakup starts to occur.

Inelastic and one neutron transfer cross sections at energies around the Coulomb barrier were used to derive dynamic polarization potential (DPP) for the 7 Li + 27 Al system. The DPP due to breakup, obtained in a simple way, indicates that its real part is repulsive at near barrier energies.

A theoretical study of the influence of configuration mixing on elastic scattering cross section is performed for the system 16 O + 27 Al at 100 MeV. A simple two- state model space, including the 27 Al 5/2 + ground and 5/2 + excited state at 2.73 MeV, is used in the coupled channel equations. The results indicate that even a weak degree of mixing is able to sizeably affect the elastic cross section, determining mainly a damping of Fraunhofer oscillations, as observed in the experiments.

A systematic study of the response of different nuclei to the (18O,16O) two-neutron transfer reaction at 84 MeV incident energy was pursued at the INFN-LNS in Catania (Italy).The experiments were performed using several solid targets from light (9Be, 11B, 12,13C, 16O, 28Si) to heavier ones (58,64Ni, 120Sn, 208Pb). The 16O ejectiles were detected at forward angles by the MAGNEX magnetic spectrometer and identified without the need of time of flight measurements. Exploiting the large momentum (≈ 25%) and angular (50 msr) acceptance of the spectrometer, energy spectra were obtained with a relevant yield up to about 20 MeV excitation energy.A common feature of the light nuclei spectra is the strong population of states with well known configuration of two-particle over a core and the appearance of unknown resonant structures in the continuum. These latter can reveal the excitation of a collective mode connected with the transfer of a pair.For the heavier nuclei as 66Ni a completely different behaviour is observed indicating the presence of more dissipative processes in the reaction mechanisms that hide the spectroscopic information.

BACKGROUND: Compared with normal children, RSV-related hospi-talization (RSVH) rates in children with HSCHD are 2-4 fold higher even up to 2 years of age with an overall weighted mean mortality rate of 5.2%. Pediatric advisory guidelines recommend prophylaxis against respiratory syncytial virus (RSV) for infants with HSCHD. However, current recommendations cast doubt as to whether prophylaxis is beneficial beyond 1 year of age. OBJECTIVES: To determine whether there are differences in RSVH in HSCHD infants receiving palivizumab during the first versus second RSV season in the Canadian Registry of palivizumab (CARESS). DESIGN/METHODS: CARESS is a prospective registry of infants who received ≥1 dose of palivizumab at one of 32 sites across Canada during the 2005-2014 RSV seasons. Demographic data were collected at enrollment and respiratory-illness-related hospitalization events recorded monthly. In the event of a hospitalization, the relevant hospital records were reviewed by the site’s research nurse for detailed information on criteria for hospital-ization, length of stay (regular ward vs. ICU), days on respiratory support and/or intubation, and RSV test type and diagnosis. Infants aged RESULTS: 1306 (64.9%) of 2013 infants received prophylaxis only for the first season. 707 (35.1%) were prophylaxed during the second season (average age in months: 4.7 [first season] vs 14.7 [second season]). Baseline demographics for both seasons were similar. However, infants aged >1year had a more complicated neonatal course, with significantly longer neonatal length of stay (46.7 versus 25.6 days). Infants received: 4.5±1.4 injections; 90.5% of their expected injections and 88.2% of their injections within the appropriate time intervals. 26 infants in the first year (RSVH rate: 2.26%) and 11 infants in the second year (RSVH rate: 2.09%) were hospitalized. Cox regression analysis showed no significant differences in hazards between infants in their first or second year of prophylaxis in the time to first RSVH (Hazard ratio: 1.4, 95%CI 0.5-4.0, p=0.52) CONCLUSION: Infants enrolled in the CARESS database in the second RSV season had a similar hazard of RSVH as those in the first year of life. These findings suggest that infants aged >1 year with HSCHD who remain unstable, are equally at risk for RSVH and merit palivizumab prophylaxis.