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Aim. To study effects of carvedilol and metoprolol on vegetative regulation of heart and microcirculatory vessels in patients with arterial hypertension (HT) of 1-2 degrees and high body mass/obesity.Material and methods. Patients with HT of 1-2 degrees (n=25; aged 51±8 y.o.) were included in the study. Registration of 0,1 Hz-fluctuations in heart rhythm variability and microcirculation change was performed during passive orthostatic test at spontaneous breath (duration of each test stage 10 min). Synchronization of 0,1 Hz-rhythms was estimated by calculation of phases difference and a numerical measure of synchronization. Frequency estimations of heart rhythm variability spectrum were performed in high and low frequency ranges additionaly.Results. Carvedilol and metoprolol have the comparable antihypertensive effect and influence on vegetative regulation of cardiovascular system in patients with HT. Both drugs have negative influence on synchronization of 0,1 Hz-rhythms in initially high systolic blood pressure level (>150 mm Hg).Conclusion. Carvedilol and metoprolol have comparable influence on synchronization of 0,1 Hz-rhythms in cardiovascular system.

Aim. To compare the effect of fosinopril and atenolol on synchronization of heart 0.1 Hz-rhythms and blood microcirculatory.Material and methods. 63 patients at the age of 47±8 with hypertension (HT) of grade 1-2 were enrolled in the study. 0.1 Hz-oscillations in heart rate variability (HRV) and in filling of microcirculatory bed were registered during passive tilt test under spontaneous breathing. The duration of each stage of test was 10 min. Synchronization was estimated as a phase difference between 0.1 Hz-rhythms of heart rate and filling of microcirculatory bed. Frequency values of HRV spectrum in LF- and HF-ranges were also assessed.Results. Fosinopril and atenolol showed comparable effect on blood pressure (BP) reduction. Atenolol decreased in heart rate significantly. Treatment with either fosinopril or atenolol in patients with significant vegetative dysfunction resulted in repair of functional interaction between heart 0.1 Hz-regulation and microcirculatory bed. Functional dissociation of 0.1 Hz-regulation mechanisms was observed under the treatment with fosinopril or atenolol in patients with initially sufficient interaction.Conclusions. Fosinopril and atenolol influenced similarly on heart 0.1 Hz-mechanisms and microcirculation autonomic regulation in patients with HT. Atenolol is a drug of choice in patients with sympathicotony. Both drugs should be administered in according with an individual level of 0.1-Hz rhythms synchronization assessed before start of the treatment.

Aim. To assess the effects of the combination therapy with atenolol and amlodipine on the synchronisation of 0,1-Hz rhythms of heart rate variability (HRV) and distal vessel filling (DVF). Material and methods. The study included 25 patients with Stage 1–2 arterial hypertension (AH), aged 58±8 years. The registration of 0,1-Hz oscillations in HRV and DVF was performed during the passive tilt test with spontaneous breathing; each test stage lasted for 10 minutes. Synchronisation was assessed by the phase difference between 0.1 Hz-rhythms in HRV and DVF. Frequency values of the HRV spectrum in LF and HF-ranges were also assessed. The duration of combination therapy was 8 weeks. Results. In patients with AH and a markedly manifested autonomic dysfunction, the therapy with atenolol and amlodipine was associated with some improvement in the functional interaction between HRV and DVF 0,1-Hz rhythms. In the rest of AH patients, the treatment was linked to stable levels of cardiac 0,1-Hz regulation and slightly decreased synchronisation levels. All participants demonstrated an increase in the influence of respiratory parasympathetic effects. Conclusion. The combination therapy with atenolol and amlodipine effectively corrected autonomic cardiovascular dysfunction in patients with Stage 1–2 AH.