Search

Your search keyword '"B. Morelli"' showing total 96 results
Start Over Author "B. Morelli"
96 results on '"B. Morelli"'

2. Vitamin C and Cardiovascular Disease: An Update

Author

Marco B. Morelli, Jessica Gambardella, Vanessa Castellanos, Valentina Trimarco, and Gaetano Santulli

Subjects
ascorbic acid, blood pressure, coronavirus, COVID–19, dietary supplements, drug formulations, Therapeutics. Pharmacology, RM1-950
Abstract

The potential beneficial effects of the antioxidant properties of vitamin C have been investigated in a number of pathological conditions. In this review, we assess both clinical and preclinical studies evaluating the role of vitamin C in cardiac and vascular disorders, including coronary heart disease, heart failure, hypertension, and cerebrovascular diseases. Pitfalls and controversies in investigations on vitamin C and cardiovascular disorders are also discussed.

Published
2020
Full Text
View/download PDF

3. Urinary Markers in Bladder Cancer: An Update

Author

Giorgio Santoni, Maria B. Morelli, Consuelo Amantini, and Nicola Battelli

Subjects
urinary biomarkers, bladder cancer, liquid biopsy, microRNA, exosomes, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Bladder cancer (BC) is ones of the most common cancer worldwide. It is classified in muscle invasive (MIBC) and muscle non-invasive (NMIBC) BC. NMIBCs frequently recur and progress to MIBCs with a reduced survival rate and frequent distant metastasis. BC detection require unpleasant and expensive cystoscopy and biopsy, which are often accompanied by several adverse effects. Thus, there is an urgent need to develop novel diagnostic methods for initial detection and surveillance in both MIBCs and NMIBCs. Multiple urine-based tests approved by FDA for BC detection and surveillance are commercially available. However, at present, sensitivity, specificity and diagnostic accuracy of these urine-based assays are still suboptimal and, in the attend to improve them, novel molecular markers as well as multiple-assays must to be translated in clinic. Now there are growing evidence toward the use of minimally invasive “liquid biopsy” to identify biomarkers in urologic malignancy. DNA- and RNA-based markers in body fluids such as blood and urine are promising potential markers in diagnostic, prognostic, predictive and monitoring urological malignancies. Thus, circulating cell-free DNA, DNA methylation and mutations, circulating tumor cells, miRNA, IncRNA and mRNAs, cell-free proteins and peptides, and exosomes have been assessed in urine specimens. However, proteomic and genomic data must to be validated in well-designed multicenter clinical studies, before to be employed in clinic oncology.

Published
2018
Full Text
View/download PDF

4. Cardiosomal microRNAs Are Essential in Post-Infarction Myofibroblast Phenoconversion

Author

Marco B. Morelli, Jun Shu, Celestino Sardu, Alessandro Matarese, and Gaetano Santulli

Subjects
cardiac ischemia, epigenetics, exosomes, extracellular vesicles, fibroblasts, inflammation, microrna, myocardial infarction, myofibroblast activation, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

The inclusion of microRNAs (miRNAs) in extracellular microvesicles/exosomes (named cardiosomes when deriving from cardiomyocytes) allows their active transportation and ensures cell-cell communication. We hypothesize that cardiosomal miRNAs play a pivotal role in the activation of myofibroblasts following ischemic injury. Using a murine model of myocardial infarction (MI), we tested our hypothesis by measuring in isolated fibroblasts and cardiosomes the expression levels of a set of miRNAs, which are upregulated in cardiomyocytes post-MI and involved in myofibroblast phenoconversion. We found that miR-195 was significantly upregulated in cardiosomes and in fibroblasts isolated after MI compared with SHAM conditions. Moreover, primary isolated cardiac fibroblasts were activated both when incubated with cardiosomes isolated from ischemic cardiomyocytes and when cultured in conditioned medium of post-MI cardiomyocytes, whereas no significant effect was observed following incubation with cardiosomes or medium from sham cardiomyocytes. Taken together, our findings indicate for the first time that a cardiomyocyte-specific miRNA, transferred to fibroblasts in form of exosomal cargo, is crucial in the activation of myofibroblasts.

Published
2019
Full Text
View/download PDF

5. Un recorte de la visión contemporánea de la sexualidad en la adolescencia

Author

R. De Tilio, M. S. Martins, and A. B. Morelli

Subjects
sexualidad, adolescencia, concientización, Psychology, BF1-990
Abstract

Este artículo tiene objetivo de presentar un estudio descriptivo y exploratorio de partes de conversaciones de un grupo de jóvenes sobre sexualidad, mostrando como esta temática es aprendida por ellos. Para esto se realizó una entrevista grupal en una escuela. Participaron de este estudio nueve adolescentes con edad entre 14 y 17 años y se utilizó un guía de entrevista semiestructurada como instrumento de evaluación de los aspectos abordados. Fue concluido que existe un conflicto entre la familia y la escuela sobre la transmisión de informaciones acerca de la sexualidad y ambas no se encuentran preparadas. Así, es necesario buscar estrategias adecuadas que establezcan la conciencia concreta de los jóvenes, como formar grupos en los que puedan relatar sus experiencias.

Published
2013
Full Text
View/download PDF

7. Study on the uncertainty of passive area dosimetry systems for environmental radiation monitoring in the framework of the EMPIR 'Preparedness' project

Author

Lorenzo Campani, Fabio A. Vittoria, F. Mariotti, G. Iurlaro, Luciano Sperandio, Marija Majer, Paolo Ferrari, M. Nodilo, Zuzanna Baranowska, Željka Knežević, O. Ciraj Bjelac, Miloš Z. Živanović, S. Neumaier, B. Morelli, and Katarzyna Wołoszczuk

Subjects
010302 applied physics, Passive systems, Radiation, passive dosimetry systems, uncertainty budget, decision threshold, detection limit, environmental radiation monitoring, emergency preparedness, Uncertainty budget, 01 natural sciences, 030218 nuclear medicine & medical imaging, Reliability engineering, 03 medical and health sciences, 0302 clinical medicine, Preparedness, Radiological weapon, 0103 physical sciences, Environmental science, Radiation monitoring, Low dose ct, Dosimetry, Instrumentation
Abstract

One of the objectives of the EMPIR project 16ENV04 “Preparedness” is the harmonization of methodologies for the measurement of doses with passive dosimetry systems for environmental radiation monitoring in the aftermath of a nuclear or radiological event. In such cases, measurements are often performed at low radiation dose rates, close to the detection limit of the passive systems. The parameters which may affect the dosimetric results of a passive dosimetry system are analyzed and four laboratories quantitatively evaluate the uncertainties of their passive dosimetry systems. Typical uncertainties of five dosimetric systems in four European countries are compared and the main sources of uncertainty are analyzed using the results of a questionnaire compiled for this specific purpose. To compute the characteristic limits of a passive dosimetry system according to standard ISO 11929, the study of the uncertainty of the system is the first step. In this work the uncertainty budget as well as the characteristic limits (decision thresholds and detection limits) are evaluated and the limitations and strengths of a complete analysis of all parameters are presented.

Published
2021

8. The THESEUS space mission concept: science case, design and expected performances

Author

Martino Marisaldi, Enrico Bozzo, Valerie Connaughton, Dorottya Szécsi, D. Malesani, L. Maraschi, B. Cordier, P. D'Avanzo, Salvatore Capozziello, Darach Watson, C. Contini, Maryam Modjaz, Pierluigi Bellutti, M. de Pasquale, C. Guidorzi, Colleen A. Wilson-Hodge, O. Boulade, C. Adami, Y. Evangelista, A. Argan, Johan P. U. Fynbo, Y.-W. Dong, Poshak Gandhi, Allan Hornstrup, Eliana Palazzi, Andrea Bulgarelli, Andrea Comastri, E. Geza, Luciano Burderi, Giuseppe Malaguti, D. de Martino, Irfan Kuvvetli, S.-N. Zhang, Claudio Labanti, Fiamma Capitanio, Luca Izzo, Bradley Cenko, A. Melandri, Umberto Maio, Nicola Omodei, Stefano Ettori, C. Butler, S. D. Vergani, S. Zhang, Lajos G. Balázs, Patricia Schady, Federica B. Bianco, M. Branchesi, Jens Hjorth, Jochen Greiner, Felix Ryde, Jean-Gabriel Cuby, Piero Malcovati, Lorraine Hanlon, Peter G. Jonker, M. Della Valle, Elena Pian, Piotr Orleanski, Etienne Renotte, W. Skidmore, L. Sabau-Graziati, Mauro Dadina, Carl Budtz-Jørgensen, Tomaz Rodic, Giancarlo Ghirlanda, Luigi Piro, Sheila McBreen, M. Fiorini, M. Topinka, Jan Harms, Riccardo Ciolfi, Yi Chen, Giacomo Vianello, Ester Piedipalumbo, Zsolt Bagoly, Aniello Grado, Yuki Kaneko, Vito Sguera, B. Morelli, E. Le Floc'h, Luciano Rezzolla, K. Wiersema, Remo Ruffini, E. Del Monte, J. P. Osborne, M. G. Bernardini, A. Gomboc, A. De Luca, Stefano Covino, Ian Hutchinson, A. Antonelli, Enzo Brocato, Mark R. Sims, M. Razzano, Elisabetta Maiorano, Jean-Luc Atteia, J. Zicha, S. Korpela, Eros Vanzella, V. D'Elia, M. H. P. M. van Putten, Marco Feroci, Carole Mundell, A. V. Penacchioni, J. Soomin, Gabriele Ghisellini, Sandra Savaglio, N. Shigehiro, Andrea Santangelo, Antonio Martin-Carrillo, Avishay Gal-Yam, A. M. Read, Piergiorgio Casella, Giuseppe Baldazzi, B. Ciardi, Pawan Kumar, Li Song, V. Lebrun, G. Zampa, Daisuke Yonetoku, S. Vojtech, Gregor Rauw, Piero Rosati, A. J. Castro-Tirado, Bruce Gendre, Tsvi Piran, A. Rachevski, S. Basa, T. Li, Michela Uslenghi, Gianluca Morgante, Michèle Lavagna, Pascal Chardonnet, Andrew MacFadyen, Asaf Pe'er, Sandro Mereghetti, Alessandro Drago, M. Hafizi, Richard Willingale, D. Morris, Bing Zhang, Paolo Giommi, Andrea Ferrara, Mauro Orlandini, Maria Giovanna Dainotti, N. Masetti, Yuji Urata, Maxim Lyutikov, A. Vacchi, László L. Kiss, E. Campolongo, M. Boer, Lorenzo Amati, Diego Götz, Andrew Blain, M. T. Botticella, C. Tenzer, Monica Colpi, Victor Reglero, Roberto Mignani, Michael S. Briggs, Joseph Caruana, Elizabeth R. Stanway, S. Colafrancesco, Francesca Panessa, H. U. Nargaard-Nielsen, F. Lu, Giuseppe Bertuccio, A. Paizis, P. Romano, S. Vercellone, Luciano Nicastro, S. Paltani, G. Pareschi, G. Stratta, V. Petrosian, João Braga, N. Zampa, Nial Tanvir, James E. Rhoads, Raffaella Margutti, Luca Valenziano, Søren Brandt, S. Boci, Andrea Rossi, Paul J. Callanan, Annalisa Celotti, N. Kawai, René Hudec, Francesco Longo, Primo Attina, G. L. Israel, F. Fuschino, Fabio Finelli, M. Hernanz, Ruben Salvaterra, F. Frontera, P. T. O'Brien, Sergio Campana, Rupal Basak, Riccardo Campana, Eleonora Troja, Jordan Camp, Petr Páta, S. Piranomonte, G. Tagliaferri, Sylvain Guiriec, R. L. C. Starling, B. B. Zhang, Natalia Auricchio, Serena Vinciguerra, Département d'Astrophysique (ex SAP) (DAP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy-le-Vieux de Physique Théorique (LAPTH), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux (ARTEMIS), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Agenzia Spaziale Italiana, European Commission, Czech Grant Agency, ITA, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), THESEUS, Amati, L, O'Brien, P, Götz, D, Bozzo, E, Tenzer, C, Frontera, F, Ghirlanda, G, Labanti, C, Osborne, J, Stratta, G, Tanvir, N, Willingale, R, Attina, P, Campana, R, Castro-Tirado, A, Contini, C, Fuschino, F, Gomboc, A, Hudec, R, Orleanski, P, Renotte, E, Rodic, T, Bagoly, Z, Blain, A, Callanan, P, Covino, S, Ferrara, A, Le Floch, E, Marisaldi, M, Mereghetti, S, Rosati, P, Vacchi, A, D'Avanzo, P, Giommi, P, Piranomonte, S, Piro, L, Reglero, V, Rossi, A, Santangelo, A, Salvaterra, R, Tagliaferri, G, Vergani, S, Vinciguerra, S, Briggs, M, Campolongo, E, Ciolfi, R, Connaughton, V, Cordier, B, Morelli, B, Orlandini, M, Adami, C, Argan, A, Atteia, J, Auricchio, N, Balazs, L, Baldazzi, G, Basa, S, Basak, R, Bellutti, P, Bernardini, M, Bertuccio, G, Braga, J, Branchesi, M, Brandt, S, Brocato, E, Budtz-Jorgensen, C, Bulgarelli, A, Burderi, L, Camp, J, Capozziello, S, Caruana, J, Casella, P, Cenko, B, Chardonnet, P, Ciardi, B, Colafrancesco, S, Dainotti, M, D'Elia, V, De Martino, D, De Pasquale, M, Del Monte, E, Della Valle, M, Drago, A, Evangelista, Y, Feroci, M, Finelli, F, Fiorini, M, Fynbo, J, Gal-Yam, A, Gendre, B, Ghisellini, G, Grado, A, Guidorzi, C, Hafizi, M, Hanlon, L, Hjorth, J, Izzo, L, Kiss, L, Kumar, P, Kuvvetli, I, Lavagna, M, Li, T, Longo, F, Lyutikov, M, Maio, U, Maiorano, E, Malcovati, P, Malesani, D, Margutti, R, Martin-Carrillo, A, Masetti, N, Mcbreen, S, Mignani, R, Morgante, G, Mundell, C, Nargaard-Nielsen, H, Nicastro, L, Palazzi, E, Paltani, S, Panessa, F, Pareschi, G, Pe'Er, A, Penacchioni, A, Pian, E, Piedipalumbo, E, Piran, T, Rauw, G, Razzano, M, Read, A, Rezzolla, L, Romano, P, Ruffini, R, Savaglio, S, Sguera, V, Schady, P, Skidmore, W, Song, L, Stanway, E, Starling, R, Topinka, M, Troja, E, van Putten, M, Vanzella, E, Vercellone, S, Wilson-Hodge, C, Yonetoku, D, Zampa, G, Zampa, N, Zhang, B, Zhang, S, Antonelli, A, Bianco, F, Boci, S, Boer, M, Botticella, M, Boulade, O, Butler, C, Campana, S, Capitanio, F, Celotti, A, Chen, Y, Colpi, M, Comastri, A, Cuby, J, Dadina, M, De Luca, A, Dong, Y, Ettori, S, Gandhi, P, Geza, E, Greiner, J, Guiriec, S, Harms, J, Hernanz, M, Hornstrup, A, Hutchinson, I, Israel, G, Jonker, P, Kaneko, Y, Kawai, N, Wiersema, K, Korpela, S, Lebrun, V, Lu, F, Macfadyen, A, Malaguti, G, Maraschi, L, Melandri, A, Modjaz, M, Morris, D, Omodei, N, Paizis, A, Páta, P, Petrosian, V, Rachevski, A, Rhoads, J, Ryde, F, Sabau-Graziati, L, Shigehiro, N, Sims, M, Soomin, J, Szécsi, D, Urata, Y, Uslenghi, M, Valenziano, L, Vianello, G, Vojtech, S, Watson, D, Zicha, J, Amati, L., O'Brien, P., Götz, D., Bozzo, E., Tenzer, C., Frontera, F., Ghirlanda, G., Labanti, C., Osborne, J. P., Stratta, G., Tanvir, N., Willingale, R., Attina, P., Campana, R., Castro-Tirado, A. J., Contini, C., Fuschino, F., Gomboc, A., Hudec, R., Orleanski, P., Renotte, E., Rodic, T., Bagoly, Z., Blain, A., Callanan, P., Covino, S., Ferrara, A., Le Floch, E., Marisaldi, M., Mereghetti, S., Rosati, P., Vacchi, A., D'Avanzo, P., Giommi, P., Piranomonte, S., Piro, L., Reglero, V., Rossi, A., Santangelo, A., Salvaterra, R., Tagliaferri, G., Vergani, S., Vinciguerra, S., Briggs, M., Campolongo, E., Ciolfi, R., Connaughton, V., Cordier, B., Morelli, B., Orlandini, M., Adami, C., Argan, A., Atteia, J. -L., Auricchio, N., Balazs, L., Baldazzi, G., Basa, S., Basak, R., Gian Luca, Israel, Bellutti, P., Bernardini, M. G., Bertuccio, G., Braga, J., Branchesi, M., Brandt, S., Brocato, E., Budtz-Jorgensen, C., Bulgarelli, A., Burderi, L., Camp, J., Capozziello, S., Caruana, J., Casella, P., Cenko, B., Chardonnet, P., Ciardi, B., Colafrancesco, S., Dainotti, M. G., D'Elia, V., De Martino, D., De Pasquale, M., Del Monte, E., Della Valle, M., Drago, A., Evangelista, Y., Feroci, M., Finelli, F., Fiorini, M., Fynbo, J., Gal-Yam, A., Gendre, B., Ghisellini, G., Grado, A., Guidorzi, C., Hafizi, M., Hanlon, L., Hjorth, J., Izzo, L., Kiss, L., Kumar, P., Kuvvetli, I., Lavagna, M., Li, T., Longo, F., Lyutikov, M., Maio, U., Maiorano, E., Malcovati, P., Malesani, D., Margutti, R., Martin-Carrillo, A., Masetti, N., Mcbreen, S., Mignani, R., Morgante, G., Mundell, C., Nargaard-Nielsen, H. U., Nicastro, L., Palazzi, E., Paltani, S., Panessa, F., Pareschi, G., Pe'Er, A., Penacchioni, A. V., Pian, E., Piedipalumbo, E., Piran, T., Rauw, G., Razzano, M., Read, A., Rezzolla, L., Romano, P., Ruffini, R., Savaglio, S., Sguera, V., Schady, P., Skidmore, W., Song, L., Stanway, E., Starling, R., Topinka, M., Troja, E., van Putten, M., Vanzella, E., Vercellone, S., Wilson-Hodge, C., Yonetoku, D., Zampa, G., Zampa, N., Zhang, B., Zhang, B. B., Zhang, S., Zhang, S. -N., Antonelli, A., Bianco, F., Boci, S., Boer, M., Botticella, M. T., Boulade, O., Butler, C., Campana, S., Capitanio, F., Celotti, A., Chen, Y., Colpi, M., Comastri, A., Cuby, J. -G., Dadina, M., De Luca, A., Dong, Y. -W., Ettori, S., Gandhi, P., Geza, E., Greiner, J., Guiriec, S., Harms, J., Hernanz, M., Hornstrup, A., Hutchinson, I., Israel, G., Jonker, P., Kaneko, Y., Kawai, N., Wiersema, K., Korpela, S., Lebrun, V., Lu, F., Macfadyen, A., Malaguti, G., Maraschi, L., Melandri, A., Modjaz, M., Morris, D., Omodei, N., Paizis, A., Páta, P., Petrosian, V., Rachevski, A., Rhoads, J., Ryde, F., Sabau-Graziati, L., Shigehiro, N., Sims, M., Soomin, J., Szécsi, D., Urata, Y., Uslenghi, M., Valenziano, L., Vianello, G., Vojtech, S., Watson, D., Zicha, J., Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), ANR-16-CE31-0003,BEaPro,Using the most powerful explosion as probes of the high-redshift Universe(2016), Galaxies, Etoiles, Physique, Instrumentation ( GEPI ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire d'Astrophysique de Marseille ( LAM ), Aix Marseille Université ( AMU ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National d'Etudes Spatiales ( CNES ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de recherche en astrophysique et planétologie ( IRAP ), Université Paul Sabatier - Toulouse 3 ( UPS ) -Observatoire Midi-Pyrénées ( OMP ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire d'Annecy-le-Vieux de Physique Théorique ( LAPTH ), Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Centre National de la Recherche Scientifique ( CNRS ), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux ( ARTEMIS ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de la Côte d'Azur, Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Gotz, D., Pata, P., Szecsi, D., Department of Physics, and Amati, L. and O'Brien, P. and Götz, D. and Bozzo, E. and Tenzer, C. and Frontera, F. and Ghirlanda, G. and Labanti, C. and Osborne, J.P. and Stratta, G. and Tanvir, N. and Willingale, R. and Attina, P. and Campana, R. and Castro-Tirado, A.J. and Contini, C. and Fuschino, F. and Gomboc, A. and Hudec, R. and Orleanski, P. and Renotte, E. and Rodic, T. and Bagoly, Z. and Blain, A. and Callanan, P. and Covino, S. and Ferrara, A. and Le Floch, E. and Marisaldi, M. and Mereghetti, S. and Rosati, P. and Vacchi, A. and D'Avanzo, P. and Giommi, P. and Piranomonte, S. and Piro, L. and Reglero, V. and Rossi, A. and Santangelo, A. and Salvaterra, R. and Tagliaferri, G. and Vergani, S. and Vinciguerra, S. and Briggs, M. and Campolongo, E. and Ciolfi, R. and Connaughton, V. and Cordier, B. and Morelli, B. and Orlandini, M. and Adami, C. and Argan, A. and Atteia, J.-L. and Auricchio, N. and Balazs, L. and Baldazzi, G. and Basa, S. and Basak, R. and Bellutti, P. and Bernardini, M.G. and Bertuccio, G. and Braga, J. and Branchesi, M. and Brandt, S. and Brocato, E. and Budtz-Jorgensen, C. and Bulgarelli, A. and Burderi, L. and Camp, J. and Capozziello, S. and Caruana, J. and Casella, P. and Cenko, B. and Chardonnet, P. and Ciardi, B. and Colafrancesco, S. and Dainotti, M.G. and D'Elia, V. and De Martino, D. and De Pasquale, M. and Del Monte, E. and Della Valle, M. and Drago, A. and Evangelista, Y. and Feroci, M. and Finelli, F. and Fiorini, M. and Fynbo, J. and Gal-Yam, A. and Gendre, B. and Ghisellini, G. and Grado, A. and Guidorzi, C. and Hafizi, M. and Hanlon, L. and Hjorth, J. and Izzo, L. and Kiss, L. and Kumar, P. and Kuvvetli, I. and Lavagna, M. and Li, T. and Longo, F. and Lyutikov, M. and Maio, U. and Maiorano, E. and Malcovati, P. and Malesani, D. and Margutti, R. and Martin-Carrillo, A. and Masetti, N. and McBreen, S. and Mignani, R. and Morgante, G. and Mundell, C. and Nargaard-Nielsen, H.U. and Nicastro, L. and Palazzi, E. and Paltani, S. and Panessa, F. and Pareschi, G. and Pe'er, A. and Penacchioni, A.V. and Pian, E. and Piedipalumbo, E. and Piran, T. and Rauw, G. and Razzano, M. and Read, A. and Rezzolla, L. and Romano, P. and Ruffini, R. and Savaglio, S. and Sguera, V. and Schady, P. and Skidmore, W. and Song, L. and Stanway, E. and Starling, R. and Topinka, M. and Troja, E. and van Putten, M. and Vanzella, E. and Vercellone, S. and Wilson-Hodge, C. and Yonetoku, D. and Zampa, G. and Zampa, N. and Zhang, B. and Zhang, B.B. and Zhang, S. and Zhang, S.-N. and Antonelli, A. and Bianco, F. and Boci, S. and Boer, M. and Botticella, M.T. and Boulade, O. and Butler, C. and Campana, S. and Capitanio, F. and Celotti, A. and Chen, Y. and Colpi, M. and Comastri, A. and Cuby, J.-G. and Dadina, M. and De Luca, A. and Dong, Y.-W. and Ettori, S. and Gandhi, P. and Geza, E. and Greiner, J. and Guiriec, S. and Harms, J. and Hernanz, M. and Hornstrup, A. and Hutchinson, I. and Israel, G. and Jonker, P. and Kaneko, Y. and Kawai, N. and Wiersema, K. and Korpela, S. and Lebrun, V. and Lu, F. and MacFadyen, A. and Malaguti, G. and Maraschi, L. and Melandri, A. and Modjaz, M. and Morris, D. and Omodei, N. and Paizis, A. and Páta, P. and Petrosian, V. and Rachevski, A. and Rhoads, J. and Ryde, F. and Sabau-Graziati, L. and Shigehiro, N. and Sims, M. and Soomin, J. and Szécsi, D. and Urata, Y. and Uslenghi, M. and Valenziano, L. and Vianello, G. and Vojtech, S. and Watson, D. and Zicha, J.

Subjects
Ionization, Atmospheric Science, cosmological model, Cherenkov Telescope Array, [ PHYS.ASTR ] Physics [physics]/Astrophysics [astro-ph], Astronomy, Dark age, MASSIVE SINGLE STARS, Star formation rates, Gamma ray, 01 natural sciences, Cosmology: observation, localization, law.invention, Astrophysic, Einstein Telescope, observational cosmology, law, Observational cosmology, Re-ionization, Cosmology: observations, Dark ages, First stars, Gamma-ray: bursts, LIGO, observations [Cosmology], Telescope, 010303 astronomy & astrophysics, High sensitivity, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Multi-wavelength, energy: high, sezele, gamma-ray bursts, Aerospace Engineering, Space and Planetary Science, Astrophysics::Instrumentation and Methods for Astrophysics, imaging, star: formation, burst [Gamma-ray], observatory, Geophysics, X rays, Cosmology: observation, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, signature, Star, TIDAL DISRUPTION, Gamma-ray: burst, Astrophysics::High Energy Astrophysical Phenomena, SIMILAR-TO 6, Socio-culturale, FOS: Physical sciences, observation [Cosmology], galaxy: luminosity, X-ray astronomy: instrumentation, 7 CANDIDATE GALAXIES, Astrophysics::Cosmology and Extragalactic Astrophysics, gamma ray: burst, 114 Physical sciences, Settore FIS/03 - Fisica della Materia, X-ray, bursts [Gamma-ray], FIS/05 - ASTRONOMIA E ASTROFISICA, Settore FIS/05 - Astronomia e Astrofisica, First star, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], KAGRA, Instrumentation and Methods for Astrophysics (astro-ph.IM), Astrophysics::Galaxy Astrophysics, LIGHT CURVES, 010308 nuclear & particles physics, Gravitational wave, gravitational radiation, Astronomy and Astrophysics, 115 Astronomy, Space science, redshift, sensitivity, Redshift, NEUTRON-STAR MERGER, messenger, VIRGO, electromagnetic, LUMINOSITY FUNCTION, BLACK-HOLE, General Earth and Planetary Sciences, Gamma-ray burst, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract

THESEUS is a space mission concept aimed at exploiting Gamma-Ray Bursts for investigating the early Universe and at providing a substantial advancement of multi-messenger and time-domain astrophysics. These goals will be achieved through a unique combination of instruments allowing GRB and X-ray transient detection over a broad field of view (more than 1sr) with 0.5¿1 arcmin localization, an energy band extending from several MeV down to 0.3¿keV and high sensitivity to transient sources in the soft X-ray domain, as well as on-board prompt (few minutes) follow-up with a 0.7¿m class IR telescope with both imaging and spectroscopic capabilities. THESEUS will be perfectly suited for addressing the main open issues in cosmology such as, e.g., star formation rate and metallicity evolution of the inter-stellar and intra-galactic medium up to redshift 10, signatures of Pop III stars, sources and physics of re-ionization, and the faint end of the galaxy luminosity function. In addition, it will provide unprecedented capability to monitor the X-ray variable sky, thus detecting, localizing, and identifying the electromagnetic counterparts to sources of gravitational radiation, which may be routinely detected in the late ¿20s/early ¿30s by next generation facilities like aLIGO/ aVirgo, eLISA, KAGRA, and Einstein Telescope. THESEUS will also provide powerful synergies with the next generation of multi-wavelength observatories (e.g., LSST, ELT, SKA, CTA, ATHENA).© 2018 COSPAR, S.E. acknowledges the financial support from contracts ASI-INAF 1/009/10/0, NARO15 ASI-INAF 1/037/12/0 and ASI 2015-046-R.0. R.H. acknowledges GACR grant 13-33324S. S.V. research leading to these results has received funding from the European Union's Seventh Framework Programme for research, technological development and demonstration under grant agreement no 606176. D.S. was supported by the Czech grant 1601116S GA CR. Maria Giovanna Dainotti acknowledges funding from the European Union through the Marie Curie Action FP7-PEOPLE-2013-IOF, under grant agreement No. 626267 (>Cosmological Candles>).

Published
2018

10. The implementation in routine of the ENEA new personal photon dosemeter

Author

B. Morelli, E. Fantuzzi, F. Mariotti, G. Uleri, Mariotti, F., Uleri, G., Morelli, B., and Fantuzzi, E.

Subjects
Photon, Materials science, chemistry.chemical_element, Radiation Dosage, Sensitivity and Specificity, Thermoluminescence, chemistry.chemical_compound, Radiation Protection, Belgium, Aluminium, Occupational Exposure, Calibration, Radiology, Nuclear Medicine and imaging, Reproducibility, Radiation, Radiological and Ultrasound Technology, business.industry, Acrylonitrile butadiene styrene, Detector, Public Health, Environmental and Occupational Health, Reproducibility of Results, Equipment Design, General Medicine, Protezione dalle radiazioni ionizzanti, Equipment Failure Analysis, chemistry, Optoelectronics, Thermoluminescent Dosimetry, Thermoluminescent dosimeter, business
Abstract

The ENEA photon dosemeter, introduced in 1995, consisting of two differently filtrated LiF(Mg,Cu,P) detectors, has been modified recently. The ABS (acrylonitrile butadiene styrene) plastic support has been replaced by a new aluminium card supporting the same two detectors (LiF(Mg,Cu,P) GR200). The new card, fully developed at the ENEA-Radiation Protection Institute (which is going to be patented), can now be processed through a Harshaw Model 6600 Automated TLD Reader, a hot gas reader. This paper reports the results of the individual calibration of approximately 60,000 LiF(Mg,Cu,P) GR200 detectors inserted on the new aluminium cards. Before the implementation in routine of the new cards, the reader has been characterised. Steps and tests to be made to use the card in routine (i.e. reader stability, linearity, reproducibility, etc.) are reported. The whole dosimetric system now combines the very good performances of the Harshaw Model 6600 reader and that of LiF(Mg,Cu,P) thermoluminescent material.

Published
2006

11. Effects of iloprost on adhesion molecules and F1 + 2 in peripheral ischemia

Author

B. Morelli, Paola Faggioli, Antonino Mazzone, C. Stefanin, C. Cusa, and M. Rondena

Subjects
Pathology, medicine.medical_specialty, business.industry, Vascular disease, Cell adhesion molecule, Clinical Biochemistry, Inflammation, General Medicine, Pharmacology, medicine.disease, Biochemistry, Microcirculation, Endothelial stem cell, Medicine, Platelet, medicine.symptom, business, Receptor, Iloprost, medicine.drug
Abstract

Background Iloprost has beneficial effects on microcirculation by preventing platelet and leukocyte reciprocal activation, which is known to lead to endothelial damage and acute thrombosis. This drug also reduces inflammatory system activation by decreasing αΜβ2 integrin expression on the phagocyte membrane, might have a role in the protection and restoration of endothelial integrity and might interact with coagulation cascade activation. Design Forty patients were enrolled: 29 with systemic sclerosis (SSc) and 11 with peripheral artery disease (PAD). Iloprost was administered for 5 days in the first group and for 21 days in second group of patients. To ascertain whether iloprost modifies the parameters of endothelial and coagulation cascade activations, the plasma concentrations of S-ICAM-1 and F1 + 2 were detected in patients at baseline, after 5 days and, in PAD patients only, after 21 days of iloprost therapy. S-ICAM-1 is the endothelial counter receptor for αΜβ2 integrin and is a marker of endothelial cell activation; and F1 + 2 is a marker of coagulation cascade activation. Results After infusion of iloprost a significant decrease of S-ICAM-1 was observed in both the SSc (P

Published
2002

12. CR-39 Acceptance Test and Optimisation for Fast Neutron Dosimetry Applications

Author

B. Morelli, E. Fantuzzi, L. Patrizii, V. Togo, and G. Falangi

Subjects
Quality Control, Materials science, Nuclear engineering, Fast Neutrons, chemistry.chemical_compound, Radiation Protection, Radiation Monitoring, Acceptance testing, Radiology, Nuclear Medicine and imaging, Neutron, Irradiation, CR-39, Radiation, Radiological and Ultrasound Technology, business.industry, Public Health, Environmental and Occupational Health, General Medicine, Polyethylene, Isotropic etching, chemistry, Calibration, Indicators and Reagents, Radiation protection, business, Nuclear medicine, Quality assurance
Abstract

The ENEA fast neutron dosemeter is based on a planar PADC (poly allyl diglycol carbonate) placed in a polyethylene holder. The CR-39 (registered trademark of PPG Industries Inc.) material, produced by Intercast Europe S.p.A., has been used in the routine of the Individual Monitoring Service (IMS) since 1998. Since then, acceptance tests on average sheet background track density and sheet neutron sensitivity have been made on new batches as a quality control within a quality assurance programme of the IMS of ENEA-Institute for Radiation Protection (IRP). Dosemeters were irradiated with a 241Am-Be source at ENEA-IRP and processed through a chemical etching procedure (pre-etching with 40% KOH water solution 6.25 N and 60% ethyl alcohol at 70 degrees C followed by 12 h of etching in 6.25 N KOH water solution). In this paper we present the analysis of acceptance testing data for more than 30 sheets of CR-39 plastic produced in 1998, 1999 and 2000. Moreover, we compare the performance of sheets of CR-39 of standard composition with that of sheets of CR-39 with the addition of DOP (dioctylphthalate), in different concentrations, on the hasis of average background density, neutron sensitivity and background fluctuation that limit the lower detectable dose. This study demonstrates the need for acceptance tests to assure the quality of the dosimetric performance of these dosemeters, which is considerably dependent on the quality of the CR-39 plastic.

Published
2002

13. GIUSTIZIA PENALE E DIRITTO ALL’AUTODETERMINAZIONE DEI DATI PERSONALI NELLA REGIONE EUROPA

Author

M. P. Addis, S. Carnevale, S. Fratucello, L. Morassutto, F. B. Morelli, D. Negri, ALLEGREZZA, SILVIA, D. NEGRI, M. P. Addi, S. Allegrezza, S. Carnevale, S. Fratucello, L. Morassutto, F. B. Morelli, and D. Negri

Subjects
PRIVACY, GIUSTIZIA PENALE, CORTE EUROPEA DEI DIRITTI DELL'UOMO, DATI PERSONALI, UNIONE EUROPEA
Abstract

L'articolo si occupa di ripercorrere le tappe fondamentali dello sviluppo del concetto di privacy in Europa, con particolare riferimento alle interazioni fra il diritto fondamentale e la giustizia penale. Specifica attenzione è prestata alla giurisprudenza della Corte europea dei diritti dell'uomo e alla produzione normativa dell'Unione europea.

Published
2007

14. Determining the Photon Air Kerma Backscatter Factor Profiles for the ISO and ICRU Recommended Slab Phantoms: Comparison Between LiF Measurements and Monte Carlo Calculations

Author

F. Monteventi, B. Morelli, and Gianfranco Gualdrini

Subjects
Physics, Radiation, Radiological and Ultrasound Technology, Backscatter, business.industry, Monte Carlo method, Public Health, Environmental and Occupational Health, General Medicine, Imaging phantom, Kerma, Optics, Calibration, Slab, Radiology, Nuclear Medicine and imaging, Thermoluminescent dosimeter, Radiation protection, business
Abstract

Following the ICRU and ISO documents concemed with the calibration of photon personal dosemeters on slab phantoms, the ENEA Institute for Radiation Protection performed a series of studies aimed at adopting suitable routine procedures. The reference ISO and ICRU slab phantoms for calibrating dosemeters in terms of H p (10,α) and H p (0.07,α) have therefore been acquired. A slab phantom should in principle allow the simultaneous calibration of several dosemeters for the whole body. On the other hand, besides the inhomogeneity of the incident beam, it has to be taken into account that the phantom itself is responsible for a spatial dependence of the air kerma backscatter factor along its front face, implying a limitation of the practical calibration area. The resulis of Monte Carlo homogeneity area calculations are summarised, validated using ionisation chamber independent mapping, and a series of TL measurements of the same air kerma backscatter factor profiles are described.

Published
1999

15. A TL Dosemeter for Mixed Thermal Neutron and Gamma Fields Based on GR-200 and GR-207 Detectors

Author

E. Vilela, E. Fantuzzi, B. Morelli, Gianfranco Gualdrini, and F. Monteventi

Subjects
Physics, Radiation, Radiological and Ultrasound Technology, business.industry, Equivalent dose, Radiochemistry, Detector, Public Health, Environmental and Occupational Health, General Medicine, Neutron temperature, Dose calculation algorithm, Dosimetry, Radiology, Nuclear Medicine and imaging, Neutron, Irradiation, Radiation protection, Nuclear medicine, business
Abstract

A new ENEA dosemeter based on two TL detectors, LiF(Mg,Cu,P) (GR-200) and 7 LiF(Mg,Cu,P) (GR-207), was investigated. The different thermal neutron and gamma sensitivities of the two detectors allow a good dose equivalent estimation in mixed n-γ fields. The higher sensitivity of both detectors as compared with LiF(Mg,Ti) and 7 LiF(Mg,Ti) detectors, currently used at ENEA for routine personal dosimetry, allows a lower dose equivalent threshold to be achieved as well as a better discrimination of the neutron and gamma components of the radiation field. A dose calculation algorithm was developed and assessed by experimental tests performed both at ENEA Institute for Radiation Protection thermal neutron irradiation facility as well as at the IPSN SIGMA facility in Cadarache (France). The intercalibration test supplied the necessary guidelines for future routine dosemeter calibrations. Our results demonstrated that the new dosemeter can easily replace the currently employed dosemeter for mixed thermal neutron and gamma fields in routine personal dosimetry.

Published
1999

16. Dosimetric Performance of the Fast Neutron Dosemeter for ENEA Personal Dosimetry Service

Author

E. Fantuzzi, E. Vilela, and B. Morelli

Subjects
Physics, Radiation, Radiological and Ultrasound Technology, business.industry, Public Health, Environmental and Occupational Health, General Medicine, Solid-state nuclear track detector, Nuclear physics, Dosimetry, Radiology, Nuclear Medicine and imaging, Neutron, Radiation protection, business, Neutron dosimetry
Abstract

The Institute for Radiation Protection of ENEA has employed for many years a solid state nuclear track detector CR-39 as a fast neutron personal dosemeter with good results. The 1990 recommendations of ICRP 60 has introduced new parameters to neutron dosimetry that require harmonisation of the dosemeters' response within international recommendations. This paper reports the results of an experimental study performed at ENEA in order to investigate the dosimetric performance of two kinds of CR-39 produced in UK and Italy. Sensitivity, lowest detectable dose, background, linearity, energy and angular responses are compared between the two CR-39 materials. Irradiation tests have been performed with monoenergetic neutron beams in the range from 100 keV to 20 MeV, as well as with 252 Cf and 241 Am-Be sources. The Italian CR-39 material, used elsewhere for heavy ions detection in scientific applications, has here been comprehensively tested for neutron dosimetry purposes. Results were very satisfactory and it has therefore been introduced in the ENEA Personal Dosimetry Service.

Published
1999

17. Optimization of CR-39 for fast neutron dosimetry applications

Author

L. Patrizii, E. Vilela, P. Serra, G. Giacomelli, M. Giorgini, E. Fantuzzi, V. Togo, and B. Morelli

Subjects
Radiation, Materials science, Nuclear engineering, Detector, Radiochemistry, Registered trademark, Neutron temperature, chemistry.chemical_compound, Nuclear track, chemistry, Neutron, Experimental work, CR-39, Instrumentation, Neutron dosimetry
Abstract

We present the results of an experimental work aimed at improving the performances of the CR-39® (Registered Trademark of PPG Industries Inc.) nuclear track detector for neutron dosimetry applications. The work was done in collaboration with the Intercast Europe S.p.A., producer of CR-39 for commercial and scientific applications. We compare the CR-39 made with different additives concentrations and different polymerization processes. We evaluate the response of the CR-39 to fast neutrons from three sources: 241AmBe, 252Cf and 238PuLi. Particular attention was paid to background fluctuations that limit the lower detectable dose.

Published
1999

18. Osteogenic sarcoma of the urinary tract. personal experience

Author

B. Morelli, S. Rocca Rossetti, Carlo Terrone, D. Galliano, and M. Bianchi

Subjects
musculoskeletal diseases, Pathology, medicine.medical_specialty, business.industry, Urinary system, Medicine, General Medicine, Sarcoma, business, medicine.disease, neoplasms
Abstract

Osteosarcoma is one of the most frequent bone tumours in paediatric age. It has a strong tendency to metastatic spread. Secondary involvement of the kidney with clinical evidence is a rare event (6 cases have been reported in literature). Primary osteogenic sarcoma of the urinary tract is also very unusual (20 cases of primary renal osteosarcoma have been reported until now). To our knowledge primary ureteral osteosarcoma has never been described. We present here one case of symptomatic kidney metastasis of osteosarcoma in a 20-year-old female patient and the first case of primary osteosarcoma of the ureter in an 81-year-old male patient.

Published
1996

19. Processing Variable-depth Streamer Data - First Attempt

Author

R. Sablon, B. Morelli, Y. Gao, R. Soubaras, B. Gratacos, A. Cavalie, P. Whiting, and D. Lin

Subjects
Regional geology, Wavelet, Offset (computer science), Engineering geology, Gemology, Deconvolution, Economic geology, Geomorphology, Algorithm, Geology, Environmental geology
Abstract

Variable-depth streamer acquisition is emerging as a key technique for providing wide bandwidth seismic data. With several data sets acquired across the world, it has consistently produced high quality images in terms of seismic resolution, structure stratigraphy and low-frequency penetration. This is demonstrated through three data examples in this paper. The variation receiver depth introduces receiver ghost diversity across different offsets. Such diversity enables the joint deconvolution method to fully remove the receiver ghost. This kind of data also tends to be less noisy due to the deep tow of the cable. These two factors allow variable-depth streamer data to have a spectrum from 2.5 Hz up to the source notch. A key challenge in processing is how to optimize the de-multiple step. SRME, for example, can be difficult to apply because of variation of the receiver ghost. This problem can be handled by adjusting the model wavelet in the common offset domain.

Published
2011

20. Personal dosimetry in terms of HP(3): Monte Carlo and experimental studies

Author

Paolo Ferrari, Roberto Bedogni, E. Fantuzzi, B. Morelli, Gianfranco Gualdrini, and F. Monteventi

Subjects
Internationality, Backscatter, Monte Carlo method, Models, Biological, Risk Assessment, Sensitivity and Specificity, Imaging phantom, Kerma, Optics, Radiation Protection, Radiation Monitoring, Occupational Exposure, Conversion coefficients, Calibration, Dosimetry, Radiology, Nuclear Medicine and imaging, Computer Simulation, Eye lens, Physics, Radiation, Models, Statistical, Radiological and Ultrasound Technology, business.industry, Public Health, Environmental and Occupational Health, Reproducibility of Results, General Medicine, Italy, Body Burden, business, Monte Carlo Method, Algorithms, Relative Biological Effectiveness, Software
Abstract

H p (3) has been defined as the operational quantity for eye lens dosimetry. H p (3)/ka conversion coefficients were evaluated at the GSF (Germany) in a 30×30×15 cm 3 4-elements ICRU slab phantom for various energies and incident angles through Monte Carlo. The ISO report 12,794 suggests to employ a PMMA water filled phantom, of the same dimensions, for dosemeter calibration in terms of H p (3). The present paper briefly summarises the main aspects of a study carried out at ENEA-Radiation Protection Institute (Bologna, Italy) to provide practical procedures for the calibration of dosemeters in terms of H p (3). Tabulations of a new set conversion coefficients and air kerma backscatter factors are provided as a function of energy and incident angle. The paper demonstrates that a more accurate approach to the dosimetric assessment in terms of H p (3) could be rather simply introduced employing a reduced phantom.

Published
2007

21. The ENEA neutron personal dosimetry service

Author

E. Fantuzzi, F. Mariotti, B. Morelli, Mariotti, F., Morelli, B., and Fantuzzi, E.

Subjects
medicine.medical_specialty, Traceability, Computer science, Nuclear engineering, Radiation Dosage, Thermoluminescence, Radiation Protection, Occupational Exposure, medicine, Calibration, Dosimetry, Radiology, Nuclear Medicine and imaging, Medical physics, Neutron, European Union, Radiometry, Neutrons, Radiation, Radiological and Ultrasound Technology, business.industry, Public Health, Environmental and Occupational Health, General Medicine, Neutron temperature, Protezione dalle radiazioni ionizzanti, Italy, Radiation protection, business, Quality assurance
Abstract

The ENEA Radiation Protection Institute has been operating the only neutron personal dosimetry service in Italy since the 1970s. Since the 1980s the service has been based on PADC (poly allyl diglycol carbonate) for fast neutron dosimetry, while thermal neutron dosimetry has been performed using thermoluminescence (TL) dosemeters. Since the service was started, a number of aspects have undergone evolution. The latest and most important changes are as follows: in 1998 a new PADC material was introduced in routine, since 2001 TL thermal dosimetry has been based on LiF(Mg,Cu,P) [GR-200] and 7 LiF(Mg,Cu,P) [GR-207] detectors and since 2003 a new image analysis reading system for the fast neutron dosemeters has been used. Herein an updated summary of how the service operates and performs today is presented. The approaches to calibration and traceability to estimate the quantity of H p (10) are mentioned. Results obtained at the performance test of dosimetric services in the EU member states and Switzerland sponsored by the European Commission and organised by Eurados in 1999 are reported. Last but not least, quality assurance (QA) procedures introduced in the routine operation to track the whole process of dose evaluation (i.e. plastic QA, acceptance test, test etching bath reproducibility and 'dummy customer' (blind test) for each issuing monitoring period) are presented and discussed.

Published
2006

22. Effects of iloprost on adhesion molecules and F1 + 2 in peripheral ischemia

Author

A, Mazzone, P, Faggioli, C, Cusa, C, Stefanin, M, Rondena, and B, Morelli

Subjects
Adult, Male, Peripheral Vascular Diseases, Scleroderma, Systemic, Middle Aged, Peptide Fragments, Statistics, Nonparametric, Case-Control Studies, Humans, Female, Prothrombin, Endothelium, Vascular, Iloprost, Cell Adhesion Molecules, Platelet Aggregation Inhibitors, Aged
Abstract

Iloprost has beneficial effects on microcirculation by preventing platelet and leukocyte reciprocal activation, which is known to lead to endothelial damage and acute thrombosis. This drug also reduces inflammatory system activation by decreasing alpha M beta 2 integrin expression on the phagocyte membrane, might have a role in the protection and restoration of endothelial integrity and might interact with coagulation cascade activation.Forty patients were enrolled: 29 with systemic sclerosis (SSc) and 11 with peripheral artery disease (PAD). Iloprost was administered for 5 days in the first group and for 21 days in second group of patients. To ascertain whether iloprost modifies the parameters of endothelial and coagulation cascade activations, the plasma concentrations of S-ICAM-1 and F1 + 2 were detected in patients at baseline, after 5 days and, in PAD patients only, after 21 days of iloprost therapy. S-ICAM-1 is the endothelial counter receptor for alpha M beta 2 integrin and is a marker of endothelial cell activation; and F1 + 2 is a marker of coagulation cascade activation.After infusion of iloprost a significant decrease of S-ICAM-1 was observed in both the SSc (P0.002) and PAD patients (P0.004). Similarly, a significant decrease of F1 + 2 was observed in the SSc (P0.0004) and PAD patients (P0.003).The study provides evidence that iloprost reduces endothelial cells and coagulation cascade activations. Both of these mechanisms are responsible for improvement in microvascular functional capacity and for the long-term clinical benefit observed. After iloprost infusion, the SSc patients showed marked reductions in F1 + 2 and S-ICAM-1 concentrations that were statistically more significant relative to the PAD patients.

Published
2003

23. Un recorte de la visión contemporánea de la sexualidad en la adolescencia

Author

M. S. Martins, R. De Tilio, and A. B. Morelli

Subjects
adolescencia, Group interview, media_common.quotation_subject, Subject (philosophy), sexualidad, Human sexuality, concientización, BF1-990, General Energy, Psychology, Consciousness, Social psychology, Humanities, Theme (narrative), media_common
Abstract

Este artículo tiene objetivo de presentar un estudio descriptivo y exploratorio de partes de conversaciones de un grupo de jóvenes sobre sexualidad, mostrando como esta temática es aprendida por ellos. Para esto se realizó una entrevista grupal en una escuela. Participaron de este estudio nueve adolescentes con edad entre 14 y 17 años y se utilizó un guía de entrevista semiestructurada como instrumento de evaluación de los aspectos abordados. Fue concluido que existe un conflicto entre la familia y la escuela sobre la transmisión de informaciones acerca de la sexualidad y ambas no se encuentran preparadas. Así, es necesario buscar estrategias adecuadas que establezcan la conciencia concreta de los jóvenes, como formar grupos en los que puedan relatar sus experiencias.

Published
2014

24. Experimental and Monte Carlo Evaluations of the Dosimetric Characteristics of a Thermal Neutron Calibration Assembly

Author

B. Morelli, K. W. Burn, F. Monteventi, E. Vilela, Gianfranco Gualdrini, Vilela, E., Morelli, B., Monteventi, F., Gualdrini, G., and Burn, K. W.

Subjects
Physics, Radiation, Applicazioni di fisica e tecnologie nucleari, Radiological and Ultrasound Technology, business.industry, Equivalent dose, Nuclear engineering, Monte Carlo method, Public Health, Environmental and Occupational Health, General Medicine, Neutron temperature, Optics, Neutron flux, Calibration, Dosimetry, Radiology, Nuclear Medicine and imaging, Variance reduction, Radiation protection, business
Abstract

In the present report a thermal neutron assembly for calibrating dosimetric instruments at the ENEA Radiation Protection Institute is described. The characterization of such a facility in terms of spectral neutron fluence rate and ambient dose equivalent rate according to the ICRP60 document is shown in detail. The developed study was aimed at characterizing all the components of the field inside the three calibration cavities placed within a polyethylene cube. Besides from the experimental point of view, the assembly was also numerically investigated by means of the Monte Carlo code MCNP. These techniques allowed to calculate, besides the dosimetric quantities to be compared with the experimental results, also the detailed neutron spectra along the cavities. Special variance reduction algorithms developed at ENEA allowed to obtain a satisfactory statistics for each energy group of the spectra.

Published
1998

25. Advances in Transient Receptor Potential Vanilloid-2 Channel Expression and Function in Tumor Growth and Progression

Author

Liberati, Sonia, B. Morelli, Maria, Amantini, Consuelo, Santoni, Matteo, Nabissi, Massimo, Cardinali, Claudio, and Santoni, Giorgio

Abstract

Aim of this review is to study the role of the TRPV2 channel, a member of the TRPV subfamily of TRP channels, in tumor progression. Physiologically, the triggering of TRPV2 by agonists/activators (e.g., growth factors, hormones and cannabinoids), by inducing TRPV2 translocation from the endosome to the plasmatic membrane, inhibit cell proliferation and induce necrosis and/or apoptosis. Thus, loss or alterations of TRPV2 proliferative and apoptotic signals, results in uncontrolled proliferation and augmented resistance to apoptotic stimuli. For example in prostate cancer cells, the TRPV2 activation following lysophospholipid or adrenomedullin stimulation enhances the invasiveness of cancer cells; furthermore, the increased malignancy of castration-resistant prostate cancer cells was associated with enhanced TRPV2 expression, mainly in metastatic prostate cancer cells. In addition, the TRPV2 cellular functions may also to be related to the presence of TRPV2 variants, able to interfere with the physiological functions of normal TRPV2 channels. In this regard, bladder cancer tumors show loss or reduction of a short TRPV2 variant during cancer progression, with increased malignancy and invasiveness. High expression of TRPV2 was also observed more frequently in esophageal squamous cell carcinoma patients with advanced pT stage, lymph node metastasis and advanced pathological stage.

Published
2014

27. [Case of hypokalemic myopathy]

Author

G, Vesentini, L, Figà-Talamanca, B, Morelli, and D, Carratelli

Subjects
Diagnosis, Differential, Male, Humans, Paralysis, Hypokalemia, Middle Aged, Paralyses, Familial Periodic
Published
1978

28. Transverse colon conduit

Author

S R, Rossetti, G, Muto, B, Morelli, and A, Cicigoi

Subjects
Urinary Bladder Neoplasms, Colon, Urinary Bladder, Humans, Urinary Diversion
Published
1988

29. Thigh muscle atrophy in below-knee amputees

Author

P, Renström, G, Grimby, B, Morelli, and B, Palmertz

Subjects
Adult, Male, Muscular Atrophy, Amputees, Thigh, Biopsy, Humans, Female, Knee, Middle Aged, Tomography, X-Ray Computed, Aged
Abstract

The atrophy was evaluated by using muscle biopsies, computed tomography and measuring tape. Ten well functioning below-knee amputees with a mean age of 56 years participated. The amputees had 33 per cent type I fibres in the amputated leg compared to 38 per cent in the non-amputated leg, the difference not being significant. In the amputated leg there was less type IIA fibres (p less than 0.01), more type IIB (p less than 0.05) and type IIC fibres (p less than 0.01) than in the non-amputated leg. Atrophy (single fibres or groups of 4-5 small fibres) of both type I and type II fibres were seen in most patients. The mean muscle fibre area of the vastus lateralis of the amputated leg was 74 per cent of that of the non-amputated leg (p less than 0.05). In both legs the area of type II fibres was larger than that of type I fibres. The cross-sectional area of the whole thigh in the amputated leg was 86 per cent (p less than 0.05), of the quadriceps muscles 66 per cent (p less than 0.01) and of the hamstring muscles 80 per cent (p less than 0.05) of the area of the non-amputated leg. It was not possible to demonstrate if there was a reduction in the total number of muscle fibres. This indicates that the main cause for the reduction of muscle volume is the reduction in fibre sizes. There was no significant difference in circumference measurements when using computed tomography or measuring tape.

Published
1983

31. [Kinetic and clinical studies on a new cephalosporin: Cefotiam]

Author

M L, Soranzo, E, Capra, M, Eandi, G, Bosio, B, Salassa, L, Bendiscioli, C, Bramato, E, Musso, G, Andreoni, B, Morelli, A, Fabiano, F, Di Nola, and P, Misto

Subjects
Adult, Male, Kinetics, Cefotiam, Sarcina, Humans, Female, Tissue Distribution, Bacterial Infections, Cefotaxime, Drug Tolerance, Middle Aged, Aged
Abstract

Kinetic and clinical evaluation of cefotiam, a new cephalosporin, is reported. It was found that the drug is rapidly distributed to the tissues. Equilibrium between tissues and plasma is reached in about an hour. Some 90-91% of the dose administered is excreted in the urine, and accumulation does not occur. A clinical cure was obtained in 27 of a series of 35 patients (77.1%). Improvement was observed in 7 cases (20%). The antibiotic proved ineffective in the remaining cases (2.8%). Tolerance was excellent and there were no side-effects worthy of note.

Published
1982

33. [Recent experiences in the treatment of sleep disorders by Flunitrazepam. Double-blind study]

Author

C, Barba, G F, Gherardini, and B, Morelli

Subjects
Adult, Male, Sleep Wake Disorders, Benzodiazepinones, Clinical Trials as Topic, Depression, Substance-Related Disorders, Parkinson Disease, Middle Aged, Nitro Compounds, Anxiety Disorders, Psychoses, Alcoholic, Fluorobenzenes, Drug Combinations, Diphenhydramine, Drug Evaluation, Humans, Hypnotics and Sedatives, Female, Methaqualone, Aged
Published
1973

37. Isokinetic strength training in below-knee amputees

Author

U, Klingenstierna, P, Renström, G, Grimby, and B, Morelli

Subjects
Adult, Male, Muscles, Rehabilitation, Humans, Physical Therapy, Sports Therapy and Rehabilitation, General Medicine, Atrophy, Middle Aged, Amputation, Surgical, Aged, Exercise Therapy
Abstract

Eight below-knee amputees performed isokinetic training of knee extensor- and knee-flexor muscles for a period of 8-12 weeks at angular velocities of 60 degrees/s, 180 degrees/s and 240 degrees/s. Before and after training isokinetic and isometric knee extensor/flexor strength was measured. Muscle biopsies were taken from the vastus lateralis and the cross-sectional area of the thigh muscles was measured with computerized tomography. Peak torque of the amputated leg increased significantly in all knee-extension tests and in knee-flexion at 180 degrees/s, and in the non-amputated leg in extension at 180 degrees/s, 240 degrees/s and for isometric strength at 60 degrees knee angle. Knee-flexion strength increased at 240 degrees/s. The cross-sectional area of the muscle fibers increased in the amputated leg in all patients except one. There was no significant increase in the non-amputated leg which also was trained. The quotient between the cross-sectional areas of type II and type I fibers increased from 1.04 to 1.20 in the amputated leg, demonstrating an increase specially in the type II fibers. There was no difference in the non-amputated leg. The cross-sectional area of the thigh muscles did not show any significant change in either leg. The patients estimated their ability to walk after training to more than double the distance compared to before training. They could also manage better without walking aids. The increase in strength and the synchronous increase in the size of type II (fast twitch) fibers indicate that the training model has activated also these motor units which probably have not been given as much training earlier.

38. The AGILE Mission

Author

Tavani M, Barbiellini G, Argan A, Boffelli F, Bulgarelli A, Caraveo P, Cattaneo PW, Chen AW, Cocco V, Costa E, Del Monte E, De Paris G, Di Cocco G, Di Persio G, Donnarumma I, Evangelista Y, Feroci M, Ferrari A, Fiorini M, Fornari F, Fuschino F, Froysland T, Frutti M, Galli M, Gianotti F, Giuliani A, Labanti C, Lapshov I, Lazzarotto F, Liello F, Lipari P, Longo F, Mattaini E, Marisaldi M, Mastropietro M, Mauri A, Mauri F, Mereghetti S, Morelli E, Morselli A, Pacciani L, Pellizzoni A, Perotti F, Piano G, Picozza P, Pontoni C, Porrovecchio G, Prest M, Pucella G, Rapisarda M, Rappoldi A, Rossi E, Rubini A, Soffitta P, Traci A, Trifoglio M, Trois A, Vallazza E, Vercellone S, Vittorini V, Zambra A, Zanello D, Pittori C, Preger B, Santolamazza P, Verrecchia F, Giommi P, Colafrancesco S, Antonelli A, Cutini S, Gasparrini D, Stellato S, Fanari G, Primavera R, Tamburelli F, Viola F, Guarrera G, Salotti L, D'Amico F, Marchetti E, Crisconio M, Sabatini P, Annoni G, Alia S, Longoni A, Sanquerin R, Battilana M, Concari P, Dessimone E, Grossi R, Parise A, Monzani F, Artina E, Pavesi R, Marseguerra G, Nicolini L, Scandelli L, Soli L, Vettorello V, Zardetto E, Bonati A, Maltecca L, D'Alba E, Patane M, Babini G, Onorati F, Acquaroli L, Angelucci M, Morelli B, Agostara C, Cerone M, Michetti A, Tempesta P, D'Eramo S, Rocca F, Giannini F, Borghi G, Garavelli B, Conte M, Balasini M, Ferrario I, Vanotti M, Collavo E, Giacomazzo M., D'AMMANDO, FILIPPO, M., Tavani, G., Barbiellini, A., Argan, F., Boffelli, A., Bulgarelli, P., Caraveo, P. W., Cattaneo, A. W., Chen, V., Cocco, E., Costa, F., D'Ammando, E. D., Monte, G. D., Pari, G. D., Cocco, G. D., Persio, I., Donnarumma, Y., Evangelista, M., Feroci, A., Ferrari, M., Fiorini, F., Fornari, F., Fuschino, T., Froysland, M., Frutti, M., Galli, F., Gianotti, A., Giuliani, C., Labanti, I., Lapshov, F., Lazzarotto, F., Liello, P., Lipari, Longo, Francesco, E., Mattaini, M., Marisaldi, M., Mastropietro, A., Mauri, F., Mauri, S., Mereghetti, E., Morelli, A., Morselli, L., Pacciani, A., Pellizzoni, F., Perotti, G., Piano, P., Picozza, C., Pontoni, G., Porrovecchio, M., Prest, G., Pucella, M., Rapisarda, A., Rappoldi, E., Rossi, A., Rubini, P., Soffitta, A., Traci, M., Trifoglio, A., Troi, E., Vallazza, S., Vercellone, V., Vittorini, A., Zambra, D., Zanello, C., Pittori, B., Preger, P., Santolamazza, F., Verrecchia, P., Giommi, S., Colafrancesco, A., Antonelli, S., Cutini, D., Gasparrini, S., Stellato, G., Fanari, R., Primavera, F., Tamburelli, F., Viola, G., Guarrera, L., Salotti, F., D'Amico, E., Marchetti, M., Crisconio, P., Sabatini, G., Annoni, S., Alia, A., Longoni, R., Sanquerin, M., Battilana, P., Concari, E., Dessimone, R., Grossi, A., Parise, F., Monzani, E., Artina, R., Pavesi, G., Marseguerra, L., Nicolini, L., Scandelli, L., Soli, V., Vettorello, E., Zardetto, A., Bonati, L., Maltecca, E., D'Alba, M., Patane, G., Babini, F., Onorati, L., Acquaroli, M., Angelucci, B., Morelli, C., Agostara, M., Cerone, A., Michetti, P., Tempesta, S., D'Eramo, F., Rocca, F., Giannini, G., Borghi, B., Garavelli, M., Conte, M., Balasini, I., Ferrario, M., Vanotti, E., Collavo, M., Giacomazzo, Tavani M, Barbiellini G, Argan A, Boffelli F, Bulgarelli A, Caraveo P, Cattaneo PW, Chen AW, Cocco V, Costa E, DAmmando F, Del Monte E, De Paris G, Di Cocco G, Di Persio G, Donnarumma I, Evangelista Y, Feroci M, Ferrari A, Fiorini M, Fornari F, Fuschino F, Froysland T, Frutti M, Galli M, Gianotti F, Giuliani A, Labanti C, Lapshov I, Lazzarotto F, Liello F, Lipari P, Longo F, Mattaini E, Marisaldi M, Mastropietro M, Mauri A, Mauri F, Mereghetti S, Morelli E, Morselli A, Pacciani L, Pellizzoni A, Perotti F, Piano G, Picozza P, Pontoni C, Porrovecchio G, Prest M, Pucella G, Rapisarda M, Rappoldi A, Rossi E, Rubini A, Soffitta P, Traci A, Trifoglio M, Trois A, Vallazza E, Vercellone S, Vittorini V, Zambra A, Zanello D, Pittori C, Preger B, Santolamazza P, Verrecchia F, Giommi P, Colafrancesco S, Antonelli A, Cutini S, Gasparrini D, Stellato S, Fanari G, Primavera R, Tamburelli F, Viola F, Guarrera G, Salotti L, D'Amico F, Marchetti E, Crisconio M, Sabatini P, Annoni G, Alia S, Longoni A, Sanquerin R, Battilana M, Concari P, Dessimone E, Grossi R, Parise A, Monzani F, Artina E, Pavesi R, Marseguerra G, Nicolini L, Scandelli L, Soli L, Vettorello V, Zardetto E, Bonati A, Maltecca L, D'Alba E, Patane M, Babini G, Onorati F, Acquaroli L, Angelucci M, Morelli B, Agostara C, Cerone M, Michetti A, Tempesta P, D'Eramo S, Rocca F, Giannini F, Borghi G, Garavelli B, Conte M, Balasini M, Ferrario I, Vanotti M, Collavo E, and Giacomazzo M

Subjects
Agile, Active galactic nucleus, gamma and X ray detection, Astrophysics::High Energy Astrophysical Phenomena, media_common.quotation_subject, satellite, FOS: Physical sciences, Astrophysics, High Energy Gamma-ray Astronomy, Pulsar, astro-ph, Angular resolution, media_common, Physics, Calorimeter (particle physics), Astrophysics (astro-ph), Detector, AGILE satellite, Detectors, Astronomy and Astrophysics, Universe, Supernova, Space and Planetary Science, Orbit (dynamics), instrumentation: detectors – techniques: high angular resolution – techniques: image processing – gamma rays: observations – X-rays: general
Abstract

AGILE is an Italian Space Agency mission dedicated to the observation of the gamma-ray Universe. The AGILE very innovative instrumentation combines for the first time a gamma-ray imager (sensitive in the energy range 30 MeV - 50 GeV), a hard X-ray imager (sensitive in the range 18-60 keV) together with a Calorimeter (sensitive in the range 300 keV - 100 MeV) and an anticoincidence system. AGILE was successfully launched on April 23, 2007 from the Indian base of Sriharikota and was inserted in an equatorial orbit with a very low particle background. AGILE provides crucial data for the study of Active Galactic Nuclei, Gamma-Ray Bursts, pulsars, unidentified gamma-ray sources, Galactic compact objects, supernova remnants, TeV sources, and fundamental physics by microsecond timing. An optimal angular resolution (reaching 0.1-0.2 degrees in gamma-rays, 1-2 arcminutes in hard X-rays) and very large fields of view (2.5 sr and 1 sr, respectively) are obtained by the use of Silicon detectors integrated in a very compact instrument. The paper describes the AGILE Mission and its space and ground segments., 20 pages, 26 figures. submitted to Astron. & Astrophys

Published
2009

39. The Transient High Energy Sky and Early Universe Surveyor (THESEUS)

Author

Amati, L., O Brien, P., Goetz, D., Bozzo, E., Tenzer, C., Frontera, F., Ghirlanda, G., Labanti, C., Osborne, J. P., Stratta, G., Tanvir, N., Willingale, R., Attina, P., Campana, R., Castro-Tirado, A. J., Contini, C., Fuschino, F., Gomboc, A., Hudec, R., Orleanski, P., Renotte, E., Rodic, T., Bagoly, Z., Blain, A., Callanan, P., Covino, S., Ferrara, A., Le Floch, E., Marisaldi, M., Mereghetti, S., Rosati, P., Vacchi, A., D Avanzo, P., Giommi, P., Piranomonte, S., Piro, L., Reglero, V., Rossi, A., Santangelo, A., Salvaterra, R., Tagliaferri, G., Vergani, S., Vinciguerra, S., Briggs, M., Campolongo, E., Ciolfi, R., Connaughton, V., Cordier, B., Morelli, B., Orlandini, M., Adami, C., Argan, A., Atteia, J. -L, Auricchio, N., Balazs, L., Baldazzi, G., Basa, S., Basak, R., Bellutti, P., Bernardini, M. G., Bertuccio, G., Braga, J., Branchesi, M., Brandt, S., Brocato, E., Budtz-Jorgensen, C., Bulgarelli, A., Burderi, L., Camp, J., Capozziello, S., Caruana, J., Casella, P., Cenko, B., Chardonnet, P., Ciardi, B., Colafrancesco, S., Dainotti, M. G., D Elia, V., Martino, D., Pasquale, M., Del Monte, E., Della Valle, M., Drago, A., Evangelista, Y., Feroci, M., Finelli, F., Fiorini, M., Fynbo, J., Gal-Yam, A., Gendre, B., Ghisellini, G., Grado, A., Guidorzi, C., Hafizi, M., Hanlon, L., Hjorth, J., Izzo, L., Kiss, L., Kumar, P., Kuvvetli, I., Lavagna, M., Li, T., Longo, F., Lyutikov, M., Maio, U., Maiorano, E., Malcovati, P., Malesani, D., Margutti, R., Martin-Carrillo, A., Masetti, N., Mcbreen, S., Mignani, R., Morgante, G., Mundell, C., Nargaard-Nielsen, H. U., Nicastro, L., Palazzi, E., Paltani, S., Panessa, F., Pareschi, G., Pe Er, A., Penacchioni, A. V., Pian, E., Piedipalumbo, E., Piran, T., Rauw, G., Razzano, M., Read, A., Rezzolla, L., Romano, P., Ruffini, R., Savaglio, S., Sguera, V., Schady, P., Skidmore, W., Song, L., Stanway, E., Starling, R., Topinka, M., Troja, E., Putten, M., Vanzella, E., Vercellone, S., Wilson-Hodge, C., Yonetoku, D., Zampa, G., Zampa, N., Zhang, B., Zhang, B. B., Zhang, S., Zhang, S. -N, Antonelli, A., Bianco, F., Boci, S., Boer, M., Botticella, M. T., Boulade, O., Butler, C., Campana, S., Capitanio, F., Celotti, A., Chen, Y., Colpi, M., Comastri, A., Cuby, J. -G, Dadina, M., Andrea De Luca, Dong, Y. -W, Ettori, S., Gandhi, P., Geza, E., Greiner, J., Guiriec, S., Harms, J., Hernanz, M., Hornstrup, A., Hutchinson, I., Israel, G., Jonker, P., Kaneko, Y., Kawai, N., Wiersema, K., Korpela, S., Lebrun, V., Lu, F., Macfadyen, A., Malaguti, G., Maraschi, L., Melandri, A., Modjaz, M., Morris, D., Omodei, N., Paizis, A., Pata, P., Petrosian, V., Rachevski, A., Rhoads, J., Ryde, F., Sabau-Graziati, L., Shigehiro, N., Sims, M., Soomin, J., Szecsi, D., Urata, Y., Uslenghi, M., Valenziano, L., Vianello, G., Vojtech, S., Watson, D., Zicha, J., and L. Amati, P. O’Brien, D. Goetz, E. Bozzo, C. Tenzer, F. Frontera, G. Ghirlanda, C. Labanti, J. P. Osborne, G. Stratta, N. Tanvir, R. Willingale , P. Attina, R. Campana, A.J. Castro-Tirado, C. Contini, F. Fuschino, A. Gomboc, R. Hudec, P. Orleanski, E. Renotte, T. Rodic, Z. Bagoly, A. Blain, P. Callanan, S. Covino, A. Ferrara, E. Le Floch, M. Marisaldi, S. Mereghetti, P. Rosati, A. Vacchi, P. D’Avanzo, P. Giommi, A. Gomboc, S. Piranomonte, L. Piro, V. Reglero, A. Rossi, A. Santangelo, R. Salvaterra, G. Tagliaferri, S. Vergani, S. Vinciguerra, M. Briggs, E. Campolongo, R. Ciolfi, V. Connaughton, B. Cordier, B. Morelli, M. Orlandini, C. Adami, A. Argan, J.-L. Atteia, N. Auricchio, L. Balazs, G. Baldazzi, S. Basa, R. Basak, P. Bellutti, M. G. Bernardini, G. Bertuccio, J. Braga, M. Branchesi, S. Brandt, E. Brocato, C. Budtz-Jorgensen, A. Bulgarelli, L. Burderi, J. Camp, S. Capozziello, J. Caruana, P. Casella, B. Cenko, P. Chardonnet, B. Ciardi, S. Colafrancesco, M. G. Dainotti, V. D’Elia, D. De Martino, M. De Pasquale, E. Del Monte, M. Della Valle, A. Drago, Y. Evangelista, M. Feroci, F. Finelli, M. Fiorini, J. Fynbo, A. Gal-Yam, B. Gendre, G. Ghisellini, A. Grado, C. Guidorzi, M. Hafizi, L. Hanlon, J. Hjorth, L. Izzo, L. Kiss, P. Kumar, I. Kuvvetli, M. Lavagna, T. Li, F. Longo, M. Lyutikov, U. Maio, E. Maiorano, P. Malcovati, D. Malesani, R. Margutti, A. Martin-Carrillo, N. Masetti, S. McBreen, R. Mignani, G. Morgante, C. Mundell, H. U. Nargaard-Nielsen, L. Nicastro, E. Palazzi, S. Paltani, F. Panessa, G. Pareschi, A. Pe’er, A. V. Penacchioni, E. Pian, E. Piedipalumbo, T. Piran, G. Rauw, M. Razzano, A. Read, L. Rezzolla, P. Romano, R. Ruffini, S. Savaglio, V. Sguera, P. Schady, W. Skidmore, L. Song, E. Stanway, R. Starling, M. Topinka, E. Troja, M. van Putten, E. Vanzella, S. Vercellone, C. Wilson-Hodge, D. Yonetoku, G. Zampa, N. Zampa, B. Zhang, B. B. Zhang, S. Zhang, S.-N. Zhang, A. Antonelli, F. Bianco, S. Boci, M. Boer, M. T. Botticella, O. Boulade, C. Butler, S. Campana, F. Capitanio, A. Celotti, Y. Chen, M. Colpi, A. Comastri, J.-G. Cuby, M. Dadina, A. De Luca, Y.-W. Dong, S. Ettori, P. Gandhi, E. Geza, J. Greiner, S. Guiriec, J. Harms, M. Hernanz, A. Hornstrup, I. Hutchinson, G. Israel, P. Jonker, Y. Kaneko, N. Kawai, K. Wiersema, S. Korpela, V. Lebrun, F. Lu, A. MacFadyen, G. Malaguti, L. Maraschi, A. Melandri, M. Modjaz, D. Morris, N. Omodei, A. Paizis, P. P´ata, V. Petrosian, A. Rachevski, J. Rhoads, F. Ryde, L. Sabau-Graziati, N. Shigehiro, M. Sims, J. Soomin, D. Szecsi, Y. Urata, M. Uslenghi, L. Valenziano, G. Vianello, S. Vojtech, D. Watson, J. Zicha

Subjects
Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Instrumentation and Methods for Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Gamma-ray bursts, Cosmology: observations, dark ages, re-ionization, first stars, Astrophysics::Galaxy Astrophysics
Abstract

THESEUS is a space mission concept aimed at exploiting Gamma-Ray Bursts for investigating the early Universe and at providing a substantial advancement of multi-messenger and time-domain astrophysics. These goals will be achieved through a unique combination of instruments allowing GRBs and X-ray transients detection over a broad FOV (more than 1sr) with 0.5-1 arcmin localization, an energy band extending from several MeVs down to 0.3 keV and high sensitivity to transient sources in the soft X-ray domain, as well as on-board prompt (few minutes) follow-up with a 0.7 m class IR telescope with both imaging and spectroscopic capabilities. THESEUS will be perfectly suited for addressing the main open issues in cosmology such as, e.g., star formation rate and metallicity evolution of the inter-stellar and intra-galactic medium up to redshift ∼10, signatures of Pop III stars, sources and physics of re-ionization, and the faint end of the galaxy luminosity function. In addition, it will provide unprecedented capability to monitor the X-ray variable sky, thus detecting, localizing, and identifying the electromagnetic counterparts to sources of gravitational radiation, which may be routinely detected in the late '20s / early '30s by next generation facilities like aLIGO/ aVirgo, eLISA, KAGRA, and Einstein Telescope. THESEUS will also provide powerful synergies with the next generation of multi-wavelength observatories (e.g., LSST, ELT, SKA, CTA, ATHENA).

40. Comparison of four D-dimer assays in the context of venous thromboembolism in the emergency department.

Author

Del Ben F, Fontanini E, Azzarini G, Arini M, Marini C, Poli G, Pradella P, Parusso S, Santarossa L, Targa F, Zardo L, Giacomello R, and Morelli B

Abstract

Introduction: This observational study conducted across seven emergency care units compares the efficacy of four D-dimer detection methods, namely HemosIL D-dimer HS (HS), HemosIL D-dimer HS-500 (HS-500), VIDAS D-dimer (VIDAS), and HemosIL AcuStar D-dimer (ACUSTAR). The primary focus is on patients with a clinical suspicion of deep venous thrombosis (DVT) or pulmonary embolism (PE)., Methods: A total of 149 samples were collected from patients with suspected DVT or PE. The confirmation of DVT/PE was based on calf ultrasound or computed tomography-Angiography. Direct comparisons were made between the different detection methods, considering both their analytical performance and clinical utility. Additionally, the impact of an age-adjusted cut-off on the diagnostic accuracy of each method was assessed., Results: The results revealed comparable negative predictive value, sensitivity, and specificity across the methods, with a notable exception of increased specificity for HS compared with HS-500 (50.8% vs. 41.5%, p = 0.03). Further analysis incorporating an age-adjusted cut-off demonstrated a significant improvement in specificity for HS. When using the age-adjusted cut-off, HS exhibited a substantial increase in specificity compared with HS-500 (63.1% vs. 49.2%, p = 0.004) and demonstrated significantly higher specificity compared with VIDAS (63.1% vs. 53.8%, p = 0.04)., Conclusion: The study emphasizes the nonuniversal effect of an age-adjusted cut-off and discusses the potential necessity for different cut-off values, particularly in the case of HS-500. These findings contribute to the understanding of D-dimer detection methods in the context of DVT and PE, providing insights into their relative performances and the potential optimization through age-adjusted cut-offs., (© 2024 John Wiley & Sons Ltd.)

Published
2024
Full Text
View/download PDF

41. Outcomes of systemic bivalirudin and sodium bicarbonate purge solution for Impella 5.5.

Author

Bashline M, DiBridge J, Klass WJ, Morelli B, Kaczorowski D, Schmidhofer M, Horn ET, Gomez H, Ramanan R, Hickey GW, and Rivosecchi RM

Subjects
Humans, Anticoagulants adverse effects, Tissue Plasminogen Activator adverse effects, Sodium Bicarbonate, Retrospective Studies, Hirudins adverse effects, Peptide Fragments adverse effects, Hemorrhage chemically induced, Recombinant Proteins adverse effects, Treatment Outcome, Heparin adverse effects, Thrombocytopenia
Abstract

Background: Impella 5.5 (Abiomed; Danvers, MA) (IMP5) is a commonly used, surgically implanted, tMCS device that requires systemic anticoagulation and purge solution to avoid pump failure. To avoid heparin-induced thrombocytopenia (HIT) from unfractionated heparin (UFH) use, our program has explored the utility of bivalirudin (BIV) for systemic anticoagulation and sodium bicarbonate-dextrose purge solution (SBPS) in IMP5.5., Methods: This single center, retrospective study included 34 patients supported on IMP5.5 with BIV based AC and SBPS between December 1st 2020 to December 1st 2021.The efficacy and safety end points were incidence of development of HIT, Tissue Plasminogen Activator (tPA) use for suspected pump thrombosis, stroke, and device failure as well as clinically significant bleeding., Results: The median duration of IMP5.5 support was 9.8 days (IQR: 6-15). Most patients were bridged to HTX (58%) followed by recovery (27%) and LVAD implantation (15%). Patients were therapeutic on bivalirudin for 64% of their IMP5.5 support. One patient (2.9%) suffered from ischemic stroke and 26.5% (9) patients developed clinically significant bleeding. tPA was administered to 7(21%) patients. One patient in the entire cohort developed HIT., Conclusions: Our experience supports the use of systemic BIV and SBPS as a method to avoid heparin exposure in a patient population predisposed to the development of HIT., (© 2022 International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC.)

Published
2023
Full Text
View/download PDF

42. LCIA Formatter.

Author

Young B, Srocka M, Ingwersen W, Morelli B, Cashman S, and Henderson A

Abstract

Life Cycle Assessment (LCA) is an established and standardized methodology to comprehensively assess environmental and public health metrics across industries and products (International Organization for Standardization, 2006). The United States Environmental Protection Agency (USEPA) is developing an open source LCA tool ecosystem (Ingwersen, 2019). The ecosystem includes tools to automate the creation of life cycle inventory (LCI) datasets, which account for flows to and from nature for steps across the life cycle of products or services, and tools for life cycle impact assessment (LCIA) to support classification and characterization of the cumulative LCI to potential impacts. Impacts are expressed via indicators, either midpoint or endpoint, corresponding to different points on the environmental cause-effect chain model (Frischknecht & Jolliet, 2016). This paper describes a USEPA LCA ecosystem tool 'LCIA formatter' that extracts LCIA information from original source methods and converts the data for interoperability with the rest of the USEPA LCA ecosystem tools.

Published
2021
Full Text
View/download PDF

43. Onsite Non-potable Reuse for Large Buildings: Environmental and Economic Suitability as a Function of Building Characteristics and Location.

Author

Arden S, Morelli B, Cashman S, Ma XC, Jahne M, and Garland J

Subjects
Bioreactors, Cities, Heating, Environment, Wastewater
Abstract

Onsite non-potable reuse (NPR) is a way for buildings to conserve water using onsite sources for uses like toilet flushing, laundry and irrigation. Although early case study results are promising, aspects like system suitability, cost and environmental performance remain difficult to quantify and compare across broad geographic contexts and variable system configurations. In this study, we evaluate four NPR system types - rainwater harvesting (RWH), air-conditioning condensate harvesting (ACH), and source-separated graywater and mixed wastewater membrane bioreactors (GWMBR, WWMBR) - in terms of their ability to satisfy onsite non-potable demand, their environmental impacts and their economic cost. As part of the analysis, we developed the Non-potable Environmental and Economic Water Reuse Calculator (NEWR), a publicly available U.S. EPA web application that allows users to generate planning-level estimates of system cost and environmental performance using location and basic building characteristics as inputs. By running NEWR for a range of scenarios, we find that, across the U.S., rainfall and air-conditioner condensate are only able to satisfy a fraction of the non-potable demand typical of large buildings even under favorable climate conditions. Environmental impacts of RWH and ACH systems depend on local climate and were comparable to the ones of MBR systems where annual rainfall exceeds approximately 10 in/yr or annual condensate potential exceeds approximately 3 gal/cfm. MBR systems can meet all non-potable demands but their environmental impacts depend more on the composition of the local energy grid, owing to their greater reliance on electricity inputs. Incorporation of thermal recovery to offset building hot water heating requirements amplifies the influence of the local grid mix on environmental impacts, with mixed results depending on grid composition and whether thermal recovery offsets natural gas or electricity consumption. Additional environmental benefits are realized when NPR systems are implemented in water scarce regions with diverse topography and regions relying on groundwater sources, which increases the benefits of reducing reliance on centralized drinking water services. In terms of cost, WWMBRs were found to have the lowest cost under the largest range of building characteristics and locations, achieving cost parity with local drinking water rates when those rates were more than $7 per 1000 gallons, which occurred in 19% of surveyed cities., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Published by Elsevier Ltd.)

Published
2021
Full Text
View/download PDF

44. Evaluation of a Health Care Performance Improvement Initiative to Facilitate Optimal Clinical Outcomes in Patients Receiving Ventricular Assist Device Support.

Author

Lockard KL, Dunn E, Kunz N, Pearsol A, Schaub RD Jr, Severyn DA, Lohmann D, McCall M, Morelli B, Teuteberg JJ, Kormos RL, Sciortino CM, and Dew MA

Subjects
Adult, Aged, Female, Humans, Incidence, Male, Middle Aged, Postoperative Complications prevention & control, Prealbumin analysis, Retrospective Studies, Treatment Outcome, United States, Cardiac Surgical Procedures standards, Heart-Assist Devices standards, Length of Stay statistics & numerical data, Physical Therapy Modalities standards, Practice Guidelines as Topic, Quality Improvement standards, Ventricular Dysfunction surgery
Abstract

Background: Ventricular assist device (VAD) patients are at high risk for morbidities and mortality. One potentially beneficial component of the Joint Commission VAD Certification process is the requirement that individual VAD programs select 4 performance measures to improve and optimize patients' clinical outcomes., Problem Statement: Review of patient data after our program's first certification visit in 2008 showed that, compared to national recommendations and published reports, our patients had suboptimal outcomes in 4 areas after device implantation: length of hospital stay, receipt of early (<48 hours) postsurgical physical therapy, driveline infection incidence, and adequacy of nutritional status (prealbumin ≥18 mg/dL)., Methods: Plan-Do-Study-Act processes were implemented to shorten length of stay, increase patient receipt of early physical therapy, decrease driveline infection incidence, and improve nutritional status. With 2008 as our baseline, we deployed interventions for each outcome area across 2009 to 2017. Performance improvement activities included staff, patient, and family didactic, one-on-one, and hands-on education; procedural changes; and outcomes monitoring with feedback to staff on progress. Descriptive and inferential statistics were examined to document change in the outcomes., Outcomes: Across the performance improvement period, length of stay decreased from 40 to 23 days; physical therapy consults increased from 87% to 100% of patients; 1-year driveline infection incidence went from 38% to 23.5%; and the percentage of patients with prealbumin within the normal range increased from 84% to 90%., Implications: Performance improvement interventions may enhance ventricular assist device patient outcomes. Interventions' sustainability should be evaluated to ensure that gains are not lost over time.

Published
2020
Full Text
View/download PDF

45. Human Health, Economic and Environmental Assessment of Onsite Non-Potable Water Reuse Systems for a Large, Mixed-Use Urban Building.

Author

Arden S, Morelli B, Schoen M, Cashman S, Jahne M, Ma XC, and Garland J

Abstract

Onsite non-potable reuse (NPR) is being increasingly considered as a viable option to address water scarcity and infrastructure challenges, particularly at the building scale. However, there are a range of possible treatment technologies, source water options, and treatment system sizes, each with its unique costs and benefits. While demonstration projects are proving that these systems can be technologically feasible and protective of public health, little guidance exists for identifying systems that balance public health protection with environmental and economic performance. This study uses quantitative microbial risk assessment, life cycle assessment and life cycle cost analysis to characterize the human health, environmental and economic aspects of onsite NPR systems. Treatment trains for both mixed wastewater and source-separated graywater were modeled using a core biological process-an aerobic membrane bioreactor (AeMBR), an anaerobic membrane bioreactor (AnMBR) or recirculating vertical flow wetland (RVFW)-and additional treatment and disinfection unit processes sufficient to meet current health-based NPR guidelines. Results show that the graywater AeMBR system designed to provide 100% of onsite non-potable demand results in the lowest impacts across most environmental and human health metrics considered but costs more than the mixed-wastewater version due to the need for a separate collection system. The use of multiple metrics also allows for identification of weaknesses in systems that lead to burden shifting. For example, although the RVFW process requires less energy than the AeMBR process, the RVFW system is more environmentally impactful and costly when considering the additional unit processes required to protect human health. Similarly, we show that incorporation of thermal recovery units to reduce hot water energy consumption can offset some environmental impacts but result in increases to others, including cumulative energy demand. Results demonstrate the need for additional data on the pathogen treatment performance of NPR systems to inform NPR health guidance., Competing Interests: Conflicts of Interest: There is no conflict of interest.

Published
2020
Full Text
View/download PDF

46. Environmental and cost benefits of co-digesting food waste at wastewater treatment facilities.

Author

Morelli B, Cashman S, Ma XC, Turgeon J, Arden S, and Garland J

Subjects
Anaerobiosis, Cost-Benefit Analysis, Food, Refuse Disposal, Wastewater
Abstract

The wastewater industry is undergoing a paradigm shift from focusing solely on treatment to incorporating concepts aimed at mitigating environmental impacts such as energy and nutrient recovery and water reuse. This study uses life cycle assessment and life cycle cost analysis to investigate the effect of expanding anaerobic digestion (AD) capacity and adding combined heat and power on environmental and cost indicators at a mid-sized wastewater treatment facility (WWTF) in Massachusetts, USA. Since 2014, Massachusetts has banned the disposal of organic waste from commercial organizations producing more than one ton of material per week. The WWTF's additional digester capacity allows the co-digestion of municipal solids with a food-based engineered bioslurry due to this ban. Study data were compiled for several AD feedstock quantity and performance scenarios, and compared to a baseline scenario representative of historic plant operations prior to co-digestion. Reductions in environmental impact are demonstrated for six of eight environmental impacts, including global climate change potential and cumulative energy demand. Eutrophication potential increases by 10 percent and 24 percent across assessed scenarios. Water use remains relatively constant across scenarios. Facility energy production increases dramatically with co-digestion, satisfying 100 percent of the WWTF's thermal energy requirement and producing surplus electricity assuming full AD capacity utilization.

Published
2020
Full Text
View/download PDF

47. Criteria Air Pollutants and Greenhouse Gas Emissions from Hydrogen Production in U.S. Steam Methane Reforming Facilities.

Author

Sun P, Young B, Elgowainy A, Lu Z, Wang M, Morelli B, and Hawkins T

Subjects
California, Greenhouse Effect, Hydrogen, Methane, Steam, Air Pollutants, Greenhouse Gases
Abstract

The global and U.S. domestic effort to develop a clean energy economy and curb environmental pollution incentivizes the use of hydrogen as a transportation fuel, owing to its zero tailpipe pollutant emissions and high fuel efficiency in fuel cell electric vehicles (FCEVs). However, the hydrogen production process is not emissions free. Conventional hydrogen production via steam methane reforming (SMR) is energy intensive, coproduces carbon dioxide, and emits air pollutants. Thus, it is necessary to quantify the environmental impacts of SMR hydrogen production alongside the use-phase of FCEVs. This study fills the information gap, analyzing the greenhouse gas (GHG) and criteria air pollutant (CAP) emissions associated with hydrogen production in U.S. SMR facilities by compiling and matching the facility-reported GHG and CAP emissions data with facilities' hydrogen production data. The actual amounts of hydrogen produced at U.S. SMR facilities are often confidential. Thus, we have developed four approaches to estimate the hydrogen production amounts. The resultant GHG and CAP emissions per MJ of hydrogen produced in individual facilities were aggregated to develop emission values for both a national median and a California state median. This study also investigates the breakdown of facility emissions into combustion emissions and noncombustion emissions.

Published
2019
Full Text
View/download PDF

48. Criteria Air Pollutant and Greenhouse Gases Emissions from U.S. Refineries Allocated to Refinery Products.

Author

Sun P, Young B, Elgowainy A, Lu Z, Wang M, Morelli B, and Hawkins T

Subjects
Gasoline, Greenhouse Effect, Greenhouse Gases, Petroleum
Abstract

Using Greenhouse Gas Reporting Program data (GHGRP) and National Emissions Inventory data from 2014, we investigate U.S. refinery greenhouse gas (GHG) emissions (CO 2 , CH 4 , and N 2 O) and criteria air pollutant (CAP) emissions (VOC, CO, NO x , SO 2 , PM 10 , and PM 2.5 ). The study derives (1) combustion emission factors (EFs) of refinery fuels (e.g., refinery catalyst coke and refinery combined gas), (2) U.S. refinery GHG emissions and CAP emissions per crude throughput at the national and regional levels, and (3) GHG and CAP emissions attributable to U.S. refinery products. The latter two emissions were further itemized by source: combustion emission, process emission, and facility-wide emission. We estimated U.S. refinery product GHG and CAP emissions via energy allocation at the refinery process unit level. The unit energy demand and unit flow information were adopted from the Petroleum Refinery Life Cycle Inventory Model (PRELIM version 1.1) by fitting individual U.S. refineries. This study fills an important information gap because it (1) evaluates refinery CAP emissions along with GHG emissions and (2) provides CAP and GHG emissions not only for refinery main products (gasoline, diesel, jet fuel, etc.) but also for refinery secondary products (asphalt, lubricant, wax, light olefins, etc.).

Published
2019
Full Text
View/download PDF

49. A collaborative study by the Working Group on Hemostasis and Thrombosis of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology (SIBioC) on the interference of haemolysis on five routine blood coagulation tests by evaluation of 269 paired haemolysed/non-haemolysed samples.

Author

Novelli C, Vidali M, Brando B, Morelli B, Andreani G, Arini M, Calzoni P, Giacomello R, Montaruli B, Muccini E, Papa A, Pradella P, Ruocco L, Siviero F, Viola FG, Zanchetta M, Zardo L, and Lippi G

Subjects
Humans, Intersectoral Collaboration, Time Factors, Blood Coagulation Tests methods, Hemolysis, Hemostasis, Societies, Scientific, Thrombosis blood
Abstract

Introduction: Haemolysis is the leading cause of sample rejection in laboratory haemostasis. Most studies focused on artificially haemolysed samples. The aim of this study was a prospective assessment of spontaneous haemolysis on haemostasis tests, by comparing results of haemolysed (H) versus new, non-haemolysed (NH) specimens, collected within 4hrs. As new coagulometers can identify interfering substances, visual assessment of haemolysis was also compared with instrumental haemolysis index and stratified in subclasses., Materials and Methods: Two hundred and sixty nine paired samples were collected and analysed using ACL TOP750-CTS (Instrumentation Laboratory, Bedford, USA), for prothrombin time (PT), activated partial thromboplastin time (aPTT), D-Dimer (DD), fibrinogen (Fib) and antithrombin (AT). Bias between H and NH was calculated and compared with the respective critical difference (CD)., Results: Mean bias was - 0.1 s for PT (P = 0.057), - 1.1 s for aPTT (P < 0.001), 1025 ng/mL for DD (P < 0.001), - 0.04 g/L for Fib (P = 0.258) and 1.4% for AT (P = 0.013). Bias exceeding the CD varied according to the method, with larger differences for aPTT (36.1%) and DD (17.1%) and < 8% for PT, Fib and AT. No correlation emerged between free haemoglobin values and difference in haemostasis tests in H and NH samples for any tests. Moderate/severe haemolysis involved > 95% of samples. The agreement between visual assessment and instrumental evaluation of haemolysis was 0.62., Conclusion: Spurious haemolysis deeply influences aPTT and DD, and to a lesser extent AT and Fib. Prothrombin time seems only slightly influenced, suggesting that PT can be accepted also in haemolysed samples. Although a good inter-observer correlation of haemolysis evaluation was found, the instrumental assessment of haemolysis seems recommendable., Competing Interests: Potential conflict of interest: None declared.

Published
2018
Full Text
View/download PDF

50. Critical Review of Eutrophication Models for Life Cycle Assessment.

Author

Morelli B, Hawkins TR, Niblick B, Henderson AD, Golden HE, Compton JE, Cooter EJ, and Bare JC

Subjects
Eutrophication, Fresh Water, Ecosystem, Models, Theoretical
Abstract

This paper evaluates the current state of life cycle impact assessment (LCIA) methods used to estimate potential eutrophication impacts in freshwater and marine ecosystems and presents a critical review of the underlying surface water quality, watershed, marine, and air fate and transport (F&T) models. Using a criteria rubric, we assess the potential of each method and model to contribute to further refinements of life cycle assessment (LCA) eutrophication mechanisms and nutrient transformation processes as well as model structure, availability, geographic scope, and spatial and temporal resolution. We describe recent advances in LCIA modeling and provide guidance on the best available sources of fate and exposure factors, with a focus on midpoint indicators. The critical review identifies gaps in LCIA characterization modeling regarding the availability and spatial resolution of fate factors in the soil compartment and identifies strategies to characterize emissions from soil. Additional opportunities are identified to leverage detailed F&T models that strengthen existing approaches to LCIA or that have the potential to link LCIA modeling more closely with the spatial and temporal realities of the effects of eutrophication.

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results