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An online curriculum about biological evolution was designed to promote increased student content knowledge and evidentiary reasoning. A feasibility study was conducted with 77 rural high school biology students who learned with the online biological evolution unit. Data sources included the Biological Evolution Assessment Measure (BEAM), an analysis of discussion forum posts, and a post-implementation perceptions and attitudes questionnaire. BEAM posttest scores were significantly higher than the pretest scores. However, the findings revealed that the students required additional support to develop evidentiary reasoning. Many students perceived that the Web-based curriculum would have been enhanced by increased immediate interaction and feedback. Students required greater scaffolding to support complex, process-oriented tasks. Implications for designing Web-based science instruction with curriculum materials to support students’ acquisition of content knowledge and science process skills in a Web-based setting are discussed.

We present the results of analysis of ``snapshot'' spectra of 253 metal-poor halo stars -3.8 < [Fe/H] < -1.5 obtained in the HERES survey. The spectra are analysed using an automated line profile analysis method based on the Spectroscopy Made Easy codes of Valenti & Piskunov. Elemental abundances of moderate precision have been obtained for 22 elements, C, Mg, Al, Ca, Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Zn, Sr, Y, Zr, Ba, La, Ce, Nd, Sm, and Eu, where detectable. Among the sample of 253 stars, we find 8 r-II stars and 35 r-I stars. We also find three stars with strong enhancements of Eu which are s-process rich. A significant number of new very metal-poor stars are confirmed: 49 stars with [Fe/H] < -3 and 181 stars with -3 < [Fe/H] < -2. We find one star with [Fe/H] < -3.5. We find the scatter in the abundance ratios of Mg, Ca, Sc, Ti, Cr, Fe, Co, and Ni, with respect to Fe and Mg, to be similar to the estimated relative errors and thus the cosmic scatter to be small, perhaps even non-existent. The elements C, Sr, Y, Ba and Eu, and perhaps Zr, show scatter at [Fe/H] < -2.5 significantly larger than can be explained from the errors in the analysis, implying scatter which is cosmic in origin. Significant scatter is observed in abundance ratios between light and heavy neutron-capture elements at low metallicity and low levels of r-process enrichment. (*** abridged ***), Accepted for A&A; 31 pages, 2 electronic tables presently available at http://www.astro.uu.se/~barklem/papers/heres_tables.tar.gz ; Minor corrections added

Very metal-deficient stars that exhibit enhancements of their carbon abundances are of crucial importance for understanding a number of issues -- the nature of stellar evolution among the first generations of stars, the shape of the Initial Mass Function, and the relationship between carbon enhancement and neutron-capture processes, in particular the astrophysical s-process. One recent discovery from objective-prism surveys dedicated to the discovery of metal-deficient stars is that the frequency of Carbon-Enhanced Metal-Poor (CEMP) stars increases with declining metallicity, reaching roughly 25% for [Fe/H] < -2.5. In order to explore this phenomenon in greater detail we have obtained medium-resolution (2 A) spectroscopy for about 350 of the 413 objects in the Christlieb et al. catalog of carbon-rich stars, selected from the Hamburg/ESO objective prism survey on the basis of their carbon-enhancement, rather than metal deficiency. Based on these spectra, and near-IR JHK photometry from the 2MASS Point Source Catalog, we obtain estimates of [Fe/H] and [C/Fe] for most of the stars in this sample, along with reasonably accurate determinations of their radial velocities. Of particular importance, we find that the upper envelope of carbon enhancement observed for these stars is nearly constant, at [C/H] ~ -1.0, over the metallicity range -4.0 < [Fe/H] < -2.0; this same level of [C/H] applies to the most iron-deficent star yet discovered, HE 0107-5240, at [Fe/H] = -5.3., Contributed paper to The Eigth Nuclei in the Cosmos conference, to appear (in refereed form) in Nuclear Physics A

We present the results of analysis of "snapshot" spectra (i.e., R=20,000 and S/N=50 per pixel) of 253 metal-poor halo stars −3.8

We develop an automated spectral synthesis technique for the estimation of metallicities ([Fe/H]) and carbon abundances ([C/Fe]) for metal-poor stars, including carbon-enhanced metal-poor stars, for which other methods may prove insufficient. This technique, autoMOOG, is designed to operate on relatively strong features visible in even low- to medium-resolution spectra, yielding results comparable to much more telescope-intensive high-resolution studies. We validate this method by comparison with 913 stars which have existing high-resolution and low- to medium-resolution to medium-resolution spectra, and that cover a wide range of stellar parameters. We find that at low metallicities ([Fe/H] < -2.0), we successfully recover both the metallicity and carbon abundance, where possible, with an accuracy of ~ 0.20 dex. At higher metallicities, due to issues of continuum placement in spectral normalization done prior to the running of autoMOOG, a general underestimate of the overall metallicity of a star is seen, although the carbon abundance is still successfully recovered. As a result, this method is only recommended for use on samples of stars of known sufficiently low metallicity. For these low-metallicity stars, however, autoMOOG performs much more consistently and quickly than similar, existing techniques, which should allow for analyses of large samples of metal-poor stars in the near future. Steps to improve and correct the continuum placement difficulties are being pursued., 8 pages, 7 figures; accepted for publication in AJ

We present results from a refined set of procedures for estimation of the metallicities ([Fe/H]) and carbon abundance ratios ([C/Fe]) based on a much larger sample of calibration objects (on the order of 500 stars) then were available to Rossi et al. (2005), due to a dramatic increase in the number of stars with measurements obtained from high‐resolution analyses in the past few years. We compare results obtained from a new calibration of the KP and GP indices with that obtained from a custom set of spectral synthesis based on MOOG. In cases where the GP index approaches saturation, it is clear that only spectral synthesis achieve reliable results.

The halo of the Milky Way provides unique elemental abundance and kinematic information on the first objects to form in the Universe, which can be used to tightly constrain models of galaxy formation and evolution. Although the halo was once considered a single component, evidence for its dichotomy has slowly emerged in recent years from inspection of small samples of halo objects. Here we show that the halo is indeed clearly divisible into two broadly overlapping structural components -- an inner and an outer halo -- that exhibit different spatial density profiles, stellar orbits and stellar metallicities (abundances of elements heavier than helium). The inner halo has a modest net prograde rotation, whereas the outer halo exhibits a net retrograde rotation and a peak metallicity one-third that of the inner halo. These properties indicate that the individual halo components probably formed in fundamentally different ways, through successive dissipational (inner) and dissipationless (outer) mergers and tidal disruption of proto-Galactic clumps., Comment: Two stand-alone files in manuscript, concatenated together. The first is for the main paper, the second for supplementary information. The version is consistent with the version published in Nature

We estimate the frequency of Carbon-Enhanced Metal-Poor (CEMP) stars among very metal-poor stars, based on an analysis of 349 stars with available high-resolution spectra observed as part of the Hamburg/ESO R-process Enhanced Star (HERES) survey. We obtain that {\it a lower limit of} 21 $\pm$ 2% of stars with [Fe/H] $\leq -2.0$ exhibit [C/Fe] $\geq +1.0$. These fractions are higher than have been reported by recent examinations of this question, based on substantially smaller samples of stars. We discuss the source of this difference and suggest that in order to take into account effects that result in a decrease of surface carbon abundance with advancing evolution, a definition of CEMP stars based on a [C/Fe] cutoff that varies as a function of luminosity is more appropriate. We discuss the likely occurrence of dilution and mixing for many CEMP stars, which, if properly accounted for, would increase this fraction still further., Comment: 7 pages, 3 figures. ApJL accepted

We present coordinates and available photometric information (either from previous or recent broadband UBV observations, and near-infrared photometry from the 2MASS Point Source Catalog) for 12056 stars (11516 of which are unique) identified in the HK Survey of Beers and colleagues as candidate field horizontal-branch or A-type stars. These stars, in the apparent magnitude range 10, Accepted for publication in the ApJS. Submission is 27 pages, including 3 figures and 5 tables. Note that the full catalog listing (Tables 3 and 4) will appear in the ApJS in electronic form only. These are also available by request from the first author

We develop and test a method for the estimation of metallicities ([Fe/H]) and carbon abundance ratios ([C/Fe]) for carbon-enhanced metal-poor (CEMP) stars, based on application of artificial neural networks, regressions, and synthesis models to medium-resolution (1-2 A) spectra and J-K colors. We calibrate this method by comparison with metallicities and carbon abundance determinations for 118 stars with available high-resolution analyses reported in the recent literature. The neural network and regression approaches make use of a previously defined set of line-strength indices quantifying the strength of the CaII K line and the CH G-band, in conjuction with J-K colors from the 2MASS Point Source Catalog. The use of near-IR colors, as opposed to broadband B-V colors, is required because of the potentially large affect of strong molecular carbon bands on bluer color indices. Using these methods we are able to reproduce the previously-measured [Fe/H] and [C/Fe] determinations with an accuracy of ~ 0.25 dex for stars in the metallicity interval -5.5, Comment: 51 pages, including 12 figures and 7 tables, accepted for publication in the Astronomical Journal

We present new carbon-enhanced stars identified from the third public release of the Sloan Digital Sky Survey, SDSS-DR3. We have generated synthetic spectra with varying carbon abundances, and compare them with the SDSS spectra. We have also performed a preliminary analysis of s-process enhancement in several SDSS carbon-enhanced stars. Spectral features that are sensitve to stellar luminosity and temperature have also been explored. These methods will be applied to the large set of public SDSS data, as well as to the forthcoming data from SEGUE, the Sloan Extension for Galactic Understanding and Evolution, in order to study carbon enhancement at different metallicities, the fraction of s-process enhancement that occurs in carbon-enhanced stars, and possibly isotopic carbon abundances and nitrogen abundances.

Acyclovir sodium is the drug of choice for the treatment of herpes simplex encephalitis. We treated an immunocompetent patient with a ten-day course of intravenous acyclovir sodium at the recommended dosage of 10 mg/kg every eight hours for clinically apparent herpes simplex encephalitis. After marked improvement, his condition deteriorated four days after completing acyclovir therapy. A subsequent brain biopsy specimen disclosed acyclovir-sensitive herpes simplex virus type 1. A longer duration of acyclovir therapy (14 to 21 days) should be considered for treating herpes simplex encephalitis.

Acyclovir sodium is the drug of choice for the treatment of herpes simplex encephalitis. We treated an immunocompetent patient with a ten-day course of intravenous acyclovir sodium at the recommended dosage of 10 mg/kg every eight hours for clinically apparent herpes simplex encephalitis. After marked improvement, his condition deteriorated four days after completing acyclovir therapy. A subsequent brain biopsy specimen disclosed acyclovir-sensitive herpes simplex virus type 1. A longer duration of acyclovir therapy (14 to 21 days) should be considered for treating herpes simplex encephalitis. ( JAMA 1988;259:1051-1053)