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356 results on '"B. Lindemann"'

2. The Geriatric Patient

Author

Michael J. Eliason, Cameron B. Lindemann, and Michael D. Seidman

Published
2022

3. Spotless burnsi pattern in Northern Leopard Frog (Lithobates pipiens) in Maine

Author

David E. Putnam, Trevor B. Persons, Malcolm L. Hunter, and Scott B. Lindemann

Subjects
Amphibian, biology, Lithobates pipiens, biology.animal, Zoology, Leopard frog, biology.organism_classification, Ecology, Evolution, Behavior and Systematics
Abstract

We document the spotless “burnsi” morph in Northern Leopard Frog (Lithobates pipiens) in Maine.

Published
2020

4. Axanthism in Green Frogs (Lithobates clamitans) and an American Bullfrog (Lithobates catesbeianus) in Maine

Author

Phillip G. Demaynadier, Scott B. Lindemann, Aidan M. O’Brien, and Trevor B. Persons

Subjects
Amphibian, biology, Lithobates clamitans, Bullfrog, biology.animal, Lithobates, Zoology, biology.organism_classification, Ecology, Evolution, Behavior and Systematics
Abstract

We document eight cases of axanthism in Green Frogs (Lithobates clamitans) and one case in an American Bullfrog (Lithobates catesbeianus) in Maine. Although this mutation has been previously reported for both species, this is the first confirmed documentation of “blue” L. clamitans and L. catesbeianus from Maine.

Published
2020

5. The many modes of flagellar and ciliary beating: Insights from a physical analysis

Author

Kathleen A. Lesich and Charles B. Lindemann

Subjects
Axoneme, Dynein, Bending, Review Article, Flagellum, Biology, sperm, 03 medical and health sciences, 0302 clinical medicine, Planar, Structural Biology, Cilia, Review Articles, Cytoskeleton, 030304 developmental biology, 0303 health sciences, doublets, dynein, Plane (geometry), Cilium, Torsion (mechanics), Dyneins, Cell Biology, Classical mechanics, Flagella, central pair, 030217 neurology & neurosurgery
Abstract

The mechanism that allows the axoneme of eukaryotic cilia and flagella to produce both helical and planar beating is an enduring puzzle. The nine outer doublets of eukaryotic cilia and flagella are arranged in a circle. Therefore, each doublet pair with its associated dynein motors, should produce torque to bend the flagellum in a different direction. Sequential activation of each doublet pair should, therefore result in a helical bending wave. In reality, most cilia and flagella have a well‐defined bending plane and many exhibit an almost perfectly flat (planar) beating pattern. In this analysis we examine the physics that governs flagellar bending, and arrive at two distinct possibilities that could explain the mechanism of planar beating. Of these, the mechanism with the best observational support is that the flagellum behaves as two ribbons of doublets interacting with a central partition. We also examine the physics of torsion in flagella and conclude that torsion could play a role in transitioning from a planar to a helical beating modality in long flagella. Lastly, we suggest some tests that would provide theoretical and/or experimental evaluation of our proposals.

Published
2021

8. Functional anatomy of the mammalian sperm flagellum

Author

Kathleen A. Lesich and Charles B. Lindemann

Subjects
0301 basic medicine, Axoneme, 030219 obstetrics & reproductive medicine, Hyperactivation, urogenital system, Dynein, Cell Biology, Flagellum, Biology, Sperm, Cell biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Structural Biology, Microtubule, Basal body, Sperm motility
Abstract

The eukaryotic flagellum is the organelle responsible for the propulsion of the male gamete in most animals. Without exception, sperm of all mammalian species use a flagellum for swimming. The mammalian sperm has a centrally located 9 + 2 arrangement of microtubule doublets and hundreds of accessory proteins that together constitute an axoneme. However, they also possess several characteristic peri-axonemal structures that make the mammalian sperm tail function differently. These modifications include nine outer dense fibers (ODFs) that are paired with the nine outer microtubule doublets of the axoneme, and are anchored in a structure called the connecting piece located at the base. The presence of the ODFs and connecting piece, and the absence of a basal body, dictate that physical forces generated by the dynein motors are transmitted to the base of the flagellum through the ODFs. Mammalian sperm flagella also possess a mitochondrial and a fibrous sheath that encircle most of the axoneme. These sheaths and the ODFs add mechanical rigidity to the flagellum creating the functional effect of increasing bend wavelength, which requires the entrainment of more dynein motors in the production of a single wave. The sheaths also act as a retinaculum and maintain the integrity of the central axoneme when large bending torques are generated by dynein. Large torque production is crucial to the process of hyperactivation and the unique motility transitions associated with effective fertilizing capacity. Consequently, these specialized anatomical features are essential for the effective interaction of sperm with the female reproductive tract and ovum. © 2016 Wiley Periodicals, Inc.

Published
2016

11. The physiological role of ADP and Mg2+in maintaining a stable beat cycle in bull sperm

Author

Tania G. dePinho, Kathleen A. Lesich, and Charles B. Lindemann

Subjects
Dynein, Beat (acoustics), Cell Biology, Biology, Flagellum, Sperm, Cell biology, Motor protein, Adenosine diphosphate, chemistry.chemical_compound, chemistry, Structural Biology, Microtubule, Adenosine triphosphate
Abstract

Sperm flagella derive their motive power from the motor protein dynein. In this study, we show that maintenance of the flagellar beat cycle in detergent-extracted bull sperm models is highly dependent on the ratio of Mg2+ to adenosine triphosphate (ATP). An excess of either ATP un-complexed with Mg2+, or an excess of Mg2+ without an equivalent concentration of ATP, results in the loss of beat amplitude and a reduced curvature development in the beat cycle. In addition, we find that adenosine diphosphate (ADP) can stabilize the beat cycle and permit rhythmic beating across a broader range of ATP and Mg2+ concentrations. We provide evidence that suggests that when ATP is un-complexed with Mg2+, it disrupts the beat cycle by reducing dynein adhesion and thereby, reduces the transmission of dynein-generated force between the doublets. Excess Mg2+ does not act by the same mechanism and induces a condition where the flagellum is more resistant to bending. This is consistent with the idea that high Mg2+ stabilizes rigor bridges, and ATP reduces the microtubule binding affinity of dynein. Our results may explain how intact sperm are able to sustain coordinated flagellar beating under a wide range of metabolic conditions, as intact sperm produce ADP in direct proportion to their consumption of ATP. © 2014 Wiley Periodicals, Inc.

Published
2014

12. The effects of Ca2+and ADP on dynein switching during the beat cycle of reactivated bull sperm models

Author

Tania G. dePinho, Benjamin J. Dionne, Kathleen A. Lesich, and Charles B. Lindemann

Subjects
Axoneme, 0303 health sciences, Hyperactivation, Dynein, Cell Biology, Anatomy, Biology, Flagellum, Sperm, 03 medical and health sciences, Adenosine diphosphate, chemistry.chemical_compound, 0302 clinical medicine, chemistry, Structural Biology, Biophysics, Phototaxis, Adenosine triphosphate, 030217 neurology & neurosurgery, 030304 developmental biology
Abstract

Calcium regulation of flagellar motility is the basis for chemotaxis, phototaxis, and hyperactivation responses in eukaryotic flagellates and spermatozoa. Ca2+ is the internal messenger for these responses, but the coupling between Ca2+ and the motor mechanism that generates the flagellar beat is incompletely understood. We examined the effects of Ca2+ on the flagellar curvature at the switch-points of the beat cycle in bull sperm. The sperm were detergent extracted and reactivated with 0.1 mM adenosine triphosphate (ATP). With their heads immobilized and their tails beating freely it is possible to calculate the bending torque and the transverse force acting on the flagellum at the switch-points. An increase in the free Ca2+ concentration (pCa 8 to pCa 4) significantly decreased the development of torque and t-force in the principal bending direction, while having negligible effect on the reverse bend. The action of Ca2+ was more pronounced when the sperm were also treated with 4 mM adenosine diphosphate (ADP); it was sufficient to change the direction of bending that reaches the greater curvature. We also observed that the curvature of the distal half of the flagellum became locked in one direction in the presence of Ca2+. This indicates that a subset of the dynein becomes continuously activated by Ca2+ and fails to switch with the beat cycle. Our evidence suggests this subset of dyneins is localized to doublets #1–4 of the axoneme. © 2014 Wiley Periodicals, Inc.

Published
2014

13. Ultrastructural evidence that motility changes caused by variations in ATP, Mg2+, and ADP correlate to conformational changes in reactivated bull sperm axonemes

Author

Tania G. de Pinho, Kathleen A. Lesich, Charles B. Lindemann, and Loan Dang

Subjects
Outer dense fiber, Axoneme, Dynein, Motility, Cell Biology, Flagellum, Biology, Sperm, Cell biology, Adenosine diphosphate, chemistry.chemical_compound, chemistry, Structural Biology, Sperm motility
Abstract

We report the results of an ultrastructural study of Triton X-100-extracted, Mg-adenosine triphosphate (ATP)-reactivated bull sperm. We utilized a rapid fixation method to look for differences in the flagellar apparatus that correlate to the state of motility of reactivated sperm models. In a companion article, we examined the motility characteristics induced in bull sperm models by varying the concentration ratio of ATP and Mg(2+) and the stabilizing effect of adenosine diphosphate (ADP) on coordinated beating. Based on the results of that report, we selected four dissimilar states that appeared to represent extremes. One reactivation condition produces vigorous motility similar to live sperm, another produces large amplitude, low frequency beating while the remaining two conditions produce small amplitude vibrations of the flagellum with little coordinated beating. Morphometric analysis of transmission electron micrographs of sperm from these four treatment conditions revealed statistically significant differences between the samples in regard to axoneme diameter, inter-microtubule doublet spacing, and outer dense fiber (ODF) spacing. Our results show that Mg(2+) decreases the axoneme diameter and reduces interdoublet spacing, while ATP, uncomplexed with Mg(2+) , had the opposite effect. We also provide supporting evidence that this may be due to Mg(2+) increasing, and ATP decreasing, the interdoublet adhesion of dynein. We also found that 4 mM ADP significantly increases the separation between the ODFs and the space between the ODFs and the central axoneme within the middle piece. We present a hypothetical explanation that is consistent with our results to explain how ATP, ADP, and Mg(2+) act to regulate the beat cycle. © 2014 Wiley Periodicals, Inc.

Published
2014

14. Non-Processive Force Generation by Mammalian Axonemal Dynein In Situ on Doublet Microtubules

Author

Kathleen A. Lesich, David P. Lorch, Alan J. Hunt, and Charles B. Lindemann

Subjects
Axoneme, Nexin, Cilium, Dynein, macromolecular substances, Biology, Flagellum, General Biochemistry, Genetics and Molecular Biology, Cell biology, Optical tweezers, Microtubule, Modeling and Simulation, Dynactin, biology.protein
Abstract

We utilize optical tweezers to examine displacements produced by small numbers of dynein motors located in situ on doublet microtubules from disintegrated mammalian sperm axonemes. In contrast with cytoplasmic dynein, we find that axonemal dynein is not processive, and the duration of individual force-generating interactions with a microtubule are longer than predicted from the velocity of movements generated by large ensembles of motors. These findings suggest that tension is required for rapid release of dynein following a power stroke and may explain how axonemal dynein is adapted to work in arrays within an axoneme, where cyclical bending patterns require motors to function over a range of sliding velocities.

Published
2013

15. 'Mit allen geeigneten Mitteln'

Author

Christoph Skudlik, B. Lindemann, M. Woltjen, S. Brandenburg, and S.M. John

Subjects
medicine.medical_specialty, business.industry, Liability, Occupational disease, Dermatology, Liability insurance, medicine.disease, Off-label use, Statutory law, Informed consent, Family medicine, medicine, Obligation, Medical prescription, business
Abstract

In Germany, responsibility for treatment of occupational diseases lies with the public statutory employers' liability insurances (SELI). According to their legal obligation SELI have to ascertain cure--wherever possible--"with all suitable means". Thus, dermatologists treating patients with occupational dermatoses are required to deliver the best possible therapy, which, according to the current scientific knowledge, may in some cases be off-label. For example, in occupational contact dermatitis a number of scientifically promising topical and systemic drugs are not yet licensed for this indication. Off-label prescribing is not prohibited and there are no laws limiting physician flexibility in such prescribing. SELI also allows the use of off-label drugs. The goals of optimal treatment or effective prevention of occupational disease determine the measures which can be employed. Off-label use is approved for occupational skin diseases when the medication is required for cure or prevention and its use meets generally accepted medical standards. In these cases, SELI will cover off-label drug prescriptions. However, detailed patient counseling and informed consent are mandatory.

Published
2013

16. AN S-MATRIX ANALYSIS OF THE Z-RESONANCE

Author

D. McNally, R. Fabbretti, Stefan Kirsch, G. Viertel, F. J. Rodriguez, H. R. Gustafson, H. El Mamouni, S. Morganti, G. M. Bilei, D. Antreasyan, Andrea Contin, I. Bechtluft, F. Cesaroni, Luca Lista, J. Schwenke, S. Easo, An.A. Vorobyov, D. Fernandez, X. Y. Cui, M. Gruenewald, Qi An, P. Arce, V. Plyaskin, J. Y. Liao, S. Patricelli, L. Martinez-Laso, D. Goujon, J. M. Ma, Yanwen Liu, Q. Ye, P. Kapinos, O. Adriani, Egidio Longo, A. Kasser, Lucas Taylor, F. C. Erné, Roberto Castello, P. Duinker, C. Warner, A. Atamanchuk, C. Dionisi, Pablo Garcia-Abia, Alain Hervé, Emilio Leonardi, Simonetta Gentile, Sabine Riemann, Vincenzo Innocente, L. Fredj, S. Pensotti, Valery Schegelsky, Antonino Zichichi, Ph Fisher, H. Rykaczewski, Guofan Hu, Giovanni Organtini, K. N. Qureshi, S. Goldfarb, A. Klimentov, P. Schmitz, P. Vikas, G. Tsipolitis, Georgi Sultanov, T. S. Dai, R. A. Khan, V. R. Krastev, M. T. Dova, V. P. Andreev, O. Rind, M. Chemarin, R. Bock, G. M. Chen, A. Sopczak, U. K. Chaturvedi, Maurizio Biasini, A. Bay, Samuel C.C. Ting, Marta Felcini, M. Bosetti, T. E. Coan, J. G. Branson, Kenneth Francis Read, L. Djambazov, Y. Karyotakis, K. Freudenreich, L. Z. Sun, Y. S. Lu, H. O. Cohn, M. M. Ilyas, A. Gougas, D. Hauschildt, Davide Piccolo, Lamberto Luminari, M. Vivargent, M. Sachwitz, Francesco Becattini, X. R. Shi, Z. W. Yin, Felicitas Pauss, K. Sudhakar, G. Passaleva, Carlo Civinini, M. Maolinbay, G. Raven, M. Aguilar-Benitez, M. S. Sarakinos, L. J. Gutay, A. Degré, S. Chung, P.V.K.S. Baba, Attilio Santocchia, Jean Fay, M. Dhina, F. Cotorobai, X. T. Cui, S. Rosier-Lees, P. Le Coultre, K. Hangarter, J. K. Kim, R. Starosta, D. Luckey, Gy L. Bencze, Y. J. Pei, Reinhard W. Schulte, Konrad Deiters, Raffaello D'Alessandro, M. Möller, N. Zaitsev, U. Becker, D. Gele, Jianming Qian, T. Angelescu, G. Hu, H. Anderhub, A. Krivshich, J. B. Ye, I. Duran, L. Romero, C. Maña, I. C. Brock, Herwig Schopper, M. Rattaggi, H. Postema, M. White, J. H. Field, C. Y. Chien, C. Leggett, Z. Y. Lin, Alberto Aloisio, A. Ricker, H. Kuijten, R. Barillère, S. N. Ganguli, E. Gonzalez, Steven Ahlen, Leonardo Merola, Yu. Kamyshkov, J. Mnich, A. Kirkby, Carlos Willmott, F. J. Eppling, G. J. Zhou, L. W. Jones, D. S. Yan, S. M. Ting, Speranza Falciano, G. B. Mills, A. Lebedev, Dong-Chul Son, T. Kramer, K. Mazumdar, J. J. Blaising, H. F. Chen, M. Guanziroli, F. Ferroni, Marcella Diemoz, E. Dénes, R. Sehgal, A. Buytenhuijs, Giovanni Ambrosi, M. N. Kienzle-Focacci, M. MacDermott, R. Rosmalen, Stefano Giagu, H. T. Li, R. Leiste, Christoph Paus, T. Azemoon, A. Rubbia, X. W. Tang, S. X. Wu, C. G. Yang, W. Friebel, P. Zemp, K. S. Kumar, J. G. Xu, M. Fukushima, R. de Asmundis, Wt Lin, B. L. Betev, Y. Zeng, J. P. Martin, A. Tsaregorodtsev, Bolek Wyslouch, S. Wynhoff, A. Nippe, D. Duchesneau, M. Wadhwa, S. C. Tonwar, K. Y. Lee, Frank Filthaut, B. P. Roe, C. Wang, Thomas Ferguson, D. Z. Shen, Chenjie Gu, C. F. He, Alexander Malinin, B. Monteleoni, I. Sheer, P. A. Piroué, B. Zhou, Elisabetta Gallo, P. Marchesini, D. DiBitonto, Ph. Rosselet, M. Steuer, G. Forconi, Yuehong Xie, G. Chiefari, S. Shevchenko, M. A. Niaz, A. Bujak, Oliver Kornadt, M. Pohl, Mariagrazia Alviggi, B. C.C. van der Zwaan, C. Neyer, I. Vetlitsky, W. van Rossum, P. G. Rancoita, Pierluigi Paolucci, M. Gailloud, R. C. Ball, G. Sartorelli, X. L. Wang, F. Behner, T. Paul, Marcos Cerrada, Y. Mi, J. A. Bakken, Y. F. Wang, M. Sassowsky, J. Bao, E. Shumilov, V. Shoutko, B. C. Riemers, Axel König, F. Sticozzi, B. N. Jin, J. Weber, W. Y. Chen, Ren-Yuan Zhu, Luciano Barone, W. Kittel, T. J. Wenaus, Werner Lustermann, A. Pevsner, M. Lenti, Stefan Roth, A. Nadtochy, C. Spartiotis, J. M. Le Goff, M. Bourquin, K. Strauch, Andrea Baschirotto, Adrian Biland, Chenliang Wang, D. H. Wright, Ming Zeng, N. Gheordanescu, Z. M. Wang, A. A. Syed, P. Extermann, P. Lecomte, H. Nowak, I. Leedom, B. Z. Yang, M. Caria, M. Tonutti, Yu. Galaktionov, G. Schwering, M. Rescigno, D. Perret-Gallix, G. Terzi, G. S. Sanders, S. J. Fan, A. M. Cartacci, R. Raghavan, Laurent Vuilleumier, M. Röhner, P. G. Seiler, G. Fernandex, S. Reucroft, F. Wittgenstein, S. Shotkin, L. Ludovici, E. Drago, B.C. Stringfellow, H. Hofer, K. L. Tung, J. A. Rubio, F. Plasil, Mingshui Chen, A. Koulbardis, J. Alcaraz, J. S. Lee, G. F. Susinno, A. Arefiev, M. Yzerman, A. Gurtu, Els Koffeman, M. Fabre, M. Schneegans, D. M. Lee, Dimitri Bourilkov, L. Antonov, R. Morand, Z. L. Xue, W. Wallraff, H. A. Rizvi, N. Yunus, G. Carlino, A. Marin, A. Kunin, M. Pauluzzi, Jun Guo, H. R. Dimitrov, O. Fackler, H. J. Schreiber, S. Banerjee, A. Engler, V. Koutsenko, J. M. Salicio, N. E. Moulai, Hafeez R Hoorani, E. Fiandrini, Zp Zhang, Helmut Vogel, Howard A. Stone, V. K. Gupta, B. Lindemann, L. Urbán, M. Capell, D. Boutigny, J. C. Sens, R. T. Van de Walle, Y. G. Kim, G. Finocchiaro, V. Pojidaec, R. Mount, Marcel Merk, A. C. Weber, G. Gratta, M. T. Choi, Cheng Chen, A. Mihul, E. Brambilla, B. Hartmann, Tariq Aziz, A. Hasan, D. Ren, H. S. Fesefeldt, W. J. Metzger, S. Ro, R. Bizzarri, F. DeNotaristefani, Roberto Battiston, K. Riles, J. Perrier, Z. Z. Xu, J. Wenninger, F. Marzano, Y. H. Chang, I. Scott, George Alverson, Francesca Nessi-Tedaldi, J. S. Kapustinsky, R. Malik, J. D. Burger, W. J. Burger, J. Shukla, C. Zaccardelli, G. Coignet, W. Krenz, U. Vikas, Peter Denes, G. Sauvage, Z. D. Qi, J. T. He, Gerjan Bobbink, B. Borgia, S. Khokhar, T.R. McMahon, S. Müller, F. L. Linde, R. Weill, G. Rahal-Callot, Z. F. Gong, J. M. Lubbers, W. W. Kinnison, S. C. Yeh, J. Behrens, P. J. Li, Paolo Bagnaia, J. Ulbricht, David Stickland, P. Berges, Marco Meschini, Crisostomo Sciacca, P. Lebrun, R. Klöckner, D. Kirkby, Harvey B Newman, K. Hilgers, Xd Cai, Zhuoxiang Ren, E. Nagy, R. Becker, A. L. Anderson, D. J. Schotanus, J. M. You, Marco Pieri, K. Schultze, H. Suter, BT Bouwens, F. Marion, G. A. Yang, Igor Vorobiev, G. Mirabelli, D. Lanske, M. Hebert, Christopher George Tully, Guo-Ming Chen, Panos A Razis, V. Soulimov, J. F. Zhou, I. Clare, J. Busenitz, Wolfgang Lohmann, H. Vogt, U. Uwer, A. Chen, B. Bertucci, S. C. Kim, J. Salicio, Nicanor Colino, S. Schulte, K. Lübelsmeyer, Piero Spillantini, J. Tóth, Y. Mir, C. H. Ye, D. Pandoulas, T. Spickermann, Michael Dittmar, Bernard Ille, K. Janssen, Stéphane Jézéquel, J. D. Swain, P. McBride, A. Böhm, J. Berdugo, S. Lanzano, D.W. Schmitz, G. Pascale, G.G.G. Massaro, Claudio Luci, Robert Clare, W. G. Ma, Thomas Hebbeker, Paul Lecoq, R. W. Kraemer, M. Napolitano, I. Josa-Mutuberria, H. S. Chen, L. Servoli, Shu Li, G. Landi, M. L. Brooks, Simone Paoletti, Manjit Kaur, Daqiang Zhang, E. Valente, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), CMS, Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), L3, Adriani, O., Aguilarbenitez, M., Ahlen, S., Alcaraz, J., Aloisio, Alberto, Alverson, G., Alviggi, Mariagrazia, Ambrosi, G., An, Q., Anderhub, H., Anderson, A. L., Andreev, V. P., Angelescu, T., Antonov, L., Antreasyan, D., Arce, P., Arefiev, A., Atamanchuk, A., Azemoon, T., Aziz, T., P. V. K., Bagnaia, P., Bakken, J. A., Ball, R. C., Banerjee, S., Bao, J., Barillere, R., Barone, L., Baschirotto, A., Battiston, R., Bay, A., Becattini, F., Bechtluft, J., Becker, R., Becker, U., Behner, F., Behrens, J., Bencze, G. L., Berdugo, J., Berges, P., Bertucci, B., Betev, B. L., Biasini, M., Biland, A., Bilei, G. M., Bizzarri, R., Blaising, J. J., Bobbink, G. J., Bock, R., Bohm, A., Borgia, B., Bosetti, M., Bourilkov, D., Bourquin, M., Boutigny, D., Bouwens, B., Brambilla, E., Branson, J. G., Brock, I. C., Brooks, M., Bujak, A., Burger, J. D., Burger, W. J., Busenitz, J., Buytenhuijs, A., Cai, X. D., Capell, M., Caria, M., Carlino, G., Cartacci, A. M., Castello, R., Cerrada, M., Cesaroni, F., Chang, Y. H., Chaturvedi, U. K., Chemarin, M., Chen, A., Chen, C., Chen, G., Chen, G. M., Chen, H. F., Chen, H. S., Chen, M., Chen, W. Y., Chiefari, Giovanni, Chien, C. Y., Choi, M. T., Chung, S., Civinini, C., Clare, I., Clare, R., Coan, T. E., Cohn, H. O., Coignet, G., Colino, N., Contin, A., Cotorobai, F., Cui, X. T., Cui, X. Y., Dai, T. S., Dalessandro, R., Deasmundis, R., Degre, A., Deiters, K., Denes, E., Denes, P., Denotaristefani, F., Dhina, M., Dibitonto, D., Diemoz, M., Dimitrov, H. R., Dionisi, C., Dittmar, M., Djambazov, L., Dova, M. T., Drago, E., Duchesneau, D., Duinker, P., Duran, I., Easo, S., Elmamouni, H., Engler, A., Eppling, F. J., Erne, F. C., Extermann, P., Fabbretti, R., Fabre, M., Falciano, S., Fan, S. J., Fackler, O., Fay, J., Felcini, M., Ferguson, T., Fernandez, D., Fernandez, G., Ferroni, F., Fesefeldt, H., Fiandrini, E., Field, J. H., Filthaut, F., Finocchiaro, G., Fisher, P. H., Forconi, G., Fredj, L., Freudenreich, K., Friebel, W., Fukushima, M., Gailloud, M., Galaktionov, Y., Gallo, E., Ganguli, S. N., Garciaabia, P., Gele, D., Gentile, S., Gheordanescu, N., Giagu, S., Goldfarb, S., Gong, Z. F., Gonzalez, E., Gougas, A., Goujon, D., Gratta, G., Gruenewald, M., Gu, C., Guanziroli, M., Guo, J. K., Gupta, V. K., Gurtu, A., Gustafson, H. R., Gutay, L. J., Hangarter, K., Hartmann, B., Hasan, A., Hauschildt, D., C. F., He, J. T., He, Hebbeker, T., Hebert, M., Herve, A., Hilgers, K., Hofer, H., Hoorani, H., Hu, G., G. Q., Hu, Ille, B., Ilyas, M. M., Innocente, V., Janssen, H., Jezequel, S., Jin, B. N., Jones, L. W., Josamutuberria, I., Kasser, A., Khan, R. A., Kamyshkov, Y., Kapinos, P., Kapustinsky, J. S., Karyotakis, Y., Kaur, M., Khokhar, S., Kienzlefocacci, M. N., Kim, J. K., Kim, S. C., Kim, Y. G., Kinnison, W. W., Kirkby, A., Kirkby, D., Kirsch, S., Kittel, W., Klimentov, A., Klockner, R., Konig, A. C., Koffeman, E., Kornadt, O., Koutsenko, V., Koulbardis, A., Kraemer, R. W., Kramer, T., Krastev, V. R., Krenz, W., Krivshich, A., Kuijten, H., Kumar, K. 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Subjects
Z boson, Nuclear and High Energy Physics, Particle physics, E+E ANNIHILATION, FERMION PAIR PRODUCTION, Electron–positron annihilation, QED CORRECTIONS, 01 natural sciences, Nuclear physics, ASYMMETRIES, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], 010306 general physics, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Ciencias Exactas, S-matrix, Ansatz, Physics, Annihilation, 010308 nuclear & particles physics, Física, Polarization (waves), Helicity, S matrix, Z-PEAK, Amplitude, Z-LINE-SHAPE, High Energy Physics::Experiment, Particle Physics - Experiment, Lepton
Abstract

The S matrix ansatz is a rigorously model independent approach to describe the cross-sections and asymmetries in e+e- annihilation. Using the cross-sections and asymmetries measured with the L3 detector during the 1990 and 1991 running period, we determine the mass and the width of the Z boson, the contributions of the Z exchange and of the yZ interference. Including the polarization of the t lepton in the analysis, the leptonic helicity amplitudes of the scattering process are determined assuming lepton universality. The results are compared with other model independent ansatzes as realized in ZFITTER. A systematic bias of the Z mass due to the yZ interference term is detected, which leads to an underestimation of the error on mz for model independent determinations., Facultad de Ciencias Exactas

Published
2016

17. A PRECISION EXPERIMENT ON ELECTRONS, PHOTONS AND MUONS AT LHC

Author

Felicitas Pauss, Y. Tang, E.L. Florian, G. Landi, M. Zhao, H. Hoorani, Wu Wm, Z. Wei, S. Zhang, Xu Zz, Ren-Yuan Zhu, Luciano Barone, Igor Vorobiev, H. Gao, Jin Bn, D. Luckey, A. Vorobiev, Qi An, A. Nippe, D. Richter, Hasan Ah, Alexander Malinin, Panos A Razis, G. Tsipolitis, L. Bragin, A. Gurtu, Manjit Kaur, G. Forconi, Yang Cy, Z. Guo, J. John, C. Qian, Liu Gl, P. Kapinos, S. Tzamarias, M. Gao, C. Neyer, E. Brambilla, Martin Jp, W. Chen, A. Klimentov, Wang Zm, Shi Xr, R. Desalvo, Streit, R. Eichler, M. Merk, P. G. Rancoita, Romeo Gc, P. Spillantini, W. Wang, Pierluigi Paolucci, N. E. Moulai, A. Hasan, Yonggang Wang, Péter Lévai, Lin Wl, Chen Hf, H. Vongunten, Wang Kl, F. Frasconi, Gong Zf, Zhang Yf, J. Bai, Carlos Willmott, J. Lampinen, Speranza Falciano, J. Berdugo, Zhang Xy, Zhao Gm, E. Shi, C. Williams, T. Ferguson, Yang Cg, Roberto Battiston, S. Kim, B. Borgia, Yu Cw, Y. Zeng, Chien Cy, A. Lebedev, Dong-Chul Son, T. Kramer, J. J. Blaising, Marco Meschini, H. Vogel, D. Kirkby, H. Anderhub, Xie Yy, D. Churakov, Zhou Mh, V. K. Gupta, V. Dratzig, C. Fang, Roberto Castello, Wei Cl, Ding Zs, Y. Yang, G. Liu, P. LeCoultre, W. Wallraff, J. Ulbricht, B. Springfellow, Chen Zhanying, D. Boscherini, J. Behrens, Gianpaolo Carlino, F. DeNotaristefani, Wang Yf, P. Lebrun, J. He, D. Goujon, L. Collaborat, C. Gu, S. K. Gupta, H. Shen, G. Lacommare, A. Rozjkov, Dova Mt, G. Ciancaglini, T. Ypsilantis, S. Banerjee, H. Yen, Salicio Jm, G. Bruni, S. Easo, A.H. Walenta, H. Li, V. Plyaskin, T. Pennington, S. Chen, G. Maccarone, K. Yang, X. Cui, Christopher George Tully, Springfellow Bc, Y.J. Pei, István T. Horváth, H. Elmamouni, Yan Ds, C. Delpapa, G. Laurenti, Samuel C.C. Ting, G. F. Sussino, Yen Hc, Yu Bt, Y. Zhang, Y. Ossipyan, Mariagrazia Alviggi, E. P. Velikhov, Sun Lz, J. P. Martin, L. Tauscher, Wang Jh, S. Chung, Chaturvedi Uk, Harvey B Newman, Dai Ts, K. Hilgers, G. Zhao, X. Zhang, J. Qu, P. Berges, Syed Aa, W. Wu, J. Riedlberger, G. Schwering, T. Lehmann, G. Terzi, S. 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Subjects
Physics, Nuclear and High Energy Physics, Wire chamber, Photon, Large Hadron Collider, HADRON CALORIMETRY, LUND MONTE-CARLO, Physics::Instrumentation and Detectors, Detector, TRANSVERSE-MOMENTUM, BOUND-STATES, CERIUM FLUORIDE, Particle detector, Particle identification, Semiconductor detector, Nuclear physics, Upgrade, PYTHIA VERSION 4.8, P COLLIDER, Physics::Accelerator Physics, GAS SAMPLING CALORIMETER, High Energy Physics::Experiment, POSITRON ANNIHILATIONS, Instrumentation, L3 EXPERIMENT
Abstract

We describe the upgrade of the L3 detector for running at LHC. The principle goals are the precise measurement of electrons, photons and muons.

Published
2016

18. SEARCH FOR NEUTRAL CHARMLESS B-DECAYS AT LEP

Author

S. Easo, Kati Lassila-Perini, D.W. Schmitz, G. Pascale, V. Plyaskin, Samuel C.C. Ting, J. Y. Zeng, N. Shivarov, Claudio Luci, M. Rescigno, M. T. Dova, G. Passaleva, M. W. Gruenewald, I. Josa-Mutuberria, J. Rodin, Robert Clare, W. G. Ma, Thomas Hebbeker, Paul Lecoq, R. W. Kraemer, M. Napolitano, M. T. Choi, Francesca Nessi-Tedaldi, F. C. Erné, P. Schmitz, Alexei Klimentov, S. Petrak, H. S. Chen, B. Lindemann, J. D. Burger, G. Rahal-Callot, H. El Mamouni, S. Pensotti, Valery Schegelsky, Antonino Zichichi, Alessandra Doria, Tariq Aziz, N. Scholz, S. R. Hou, M. Wadhwa, D. J. Schotanus, H. O. Cohn, Marcella Diemoz, M. Vivargent, L. Servoli, Igor Vorobiev, K. Freudenreich, C. Maña, I. C. Brock, T. Angelescu, E. Lieb, J. Casaus, Yu. Kamyshkov, Helmut Vogel, S. Mele, Kajari Mazumdar, Dai-Sik Kim, F. Di Lodovico, H. Rykaczewski, Giovanni Organtini, G. M. Bilei, A. Arefiev, Yu. Efremenko, Aa Vorobyov, A. Tsaregorodtsey, P. Bartalini, P. Levtchenko, Panos A Razis, F. Ferroni, P. Laurikainen, S. Müller, B. L. Betev, A. Lebedev, Dong-Chul Son, T. Kramer, R. Barillère, E. Brambilla, E. Valente, D. McNally, O. Toker, Y. Zeng, C. G. Yang, Xd Cai, J. J. Blaising, Stefano Giagu, K. Riles, G. Viertel, R. Fabbretti, C. Lapoint, S. Morganti, Y. Karyotakis, J. Berdugo, F. Marzano, Z. A. Liu, X. Y. Yao, Luca Lista, Mariagrazia Alviggi, G. Coignet, W. Krenz, M. Möller, J. G. Xu, H. F. Chen, M. Lenti, A. Buytenhuijs, Stefan Roth, G. Schwering, K. Schultze, H. Suter, G. F. Susinno, D. Goujon, Vincenzo Innocente, D. Fernandez, Juven Wang, I. Vetlitsky, J. Schwenke, S. Costantini, E. J. Sanchez, S. X. Wu, Marco Meschini, D. Kirkby, J. M. Le Goff, Crisostomo Sciacca, N. Gheordanescu, J. C. Pinto, Jasper Kirkby, J.V. Allaby, S. Patricelli, Sabine Riemann, R. Weill, F. Muheim, Roberto Battiston, Gerjan Bobbink, Dimitri Bourilkov, B. Borgia, S. S. Gau, M. Sassowsky, A. J.W. van Mil, H. De Boeck, Y. J. Pei, H. Kuijten, A. C. Weber, J. Busenitz, W. van Rossum, C. Burgos, Adrian Biland, G. Chiefari, S. Shevchenko, F. Behner, A. M. Cartacci, Andrea Baschirotto, Mingshui Chen, J. Gerald, R. Faccini, G. G.G. Massaro, P. G. Seiler, J. A. Rubio, M. Pauluzzi, M. N. Kienzle-Focacci, J. Ulbricht, R. Raghavan, D. DiBitonto, Ph. Rosselet, E. Fiandrini, Luca Malgeri, M. Steuer, F. J. Rodriguez, Laurent Vuilleumier, H. R. Gustafson, Joel Goldstein, P. Marchesini, Y. G. Kim, Attilio Santocchia, Jean Fay, D. Boutigny, Y. H. Chang, George Alverson, Roger Moore, Christopher George Tully, Marco Pieri, Yu. Galaktionov, G. Sauvage, J. Alcaraz, K. Banicz, An.A. Vorobyov, L. Fredj, A. Favara, Z. Z. Xu, G. Tsipolitis, D. Perret-Gallix, M. Schneegans, D. Ren, Y. Zhou, F. Cesaroni, M. Chamizo, Wolfgang Lohmann, J. Shukla, J. S. Kapustinsky, J. F. Zhou, V. Soulimov, B. De La Cruz, G. Hu, H. Vogt, G. Landi, B. Bertucci, V. Pojidaev, Simone Paoletti, O. Adriani, G. Mirabelli, Bryan R. Smith, S. C. Kim, Lucas Taylor, K. Sudhakar, B. Alpat, Emilio Leonardi, A. P. Colijn, Harvey B Newman, K. Hilgers, Nicanor Colino, L. J. Gutay, Francesca Cavallari, C. Leggett, Nicolas Produit, R. Bock, I. Clare, Suchandra Dutta, W. Lu, U. Becker, P. G. Rancoita, Manjit Kaur, A. Engler, M. Capell, J. B. Ye, Federico Cindolo, S. Mangla, K. Y. Lee, L. Baksay, F. Cotorobai, J. P. Martin, Georgi Sultanov, K. Lübelsmeyer, Piero Spillantini, Carlos Willmott, Speranza Falciano, G. Cara Romeo, B. P. Roe, I. Duran, G. Forconi, Gerard Fernandez, H. S. Fesefeldt, E. Pistolesi, G. Y. Zhu, E. Shumilov, Zheng Wang, S. C. Tonwar, W. C. van Hoek, V. Shoutko, T. S. Dai, J. C. Sens, Frank Filthaut, R. A. Khan, D. Antreasyan, B. C. Riemers, R. Leiste, Christoph Paus, H. Anderhub, Zhenyu Zhang, A. Adam, Maurizio Biasini, Jozsef Toth, Marta Felcini, A. Kunin, Thomas Ferguson, J. P. Ernenwein, P. Extermann, F. J. Eppling, G. J. Zhou, L. W. Jones, R. Völkert, C. Cecchi, B. N. Jin, H. Nowak, B. Schoeneich, P. Kapinos, Hafeez R Hoorani, Christoph Schäfer, B. Z. Yang, M. Tonutti, M. E. Sarakinos, H. Hofer, D. P. 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S., Lu, Lubelsmeyer, K., Luci, C., Luckey, D., Ludovici, L., Luminari, L., Lustermann, W., W. G., Ma, Macchiolo, A., Maity, M., Malgeri, L., Malinin, A., Mana, C., Mangla, S., Maolinbay, M., Marchesini, P., Marin, A., Martin, J. P., Marzano, F., G. G. G., Mazumdar, K., Mcnally, D., Mele, S., Merola, Leonardo, Meschini, M., Metzger, W. J., Mi, Y., Mihul, A., A. J. W., Mirabelli, G., Mnich, J., Moller, M., Monteleoni, B., Moore, R., Morand, R., Morganti, S., Mount, R., Muller, S., Muheim, F., Nagy, E., Nahn, S., Napolitano, Marco, Nessitedaldi, F., Newman, H., Nippe, A., Nowak, H., Organtini, G., Ostonen, R., Pandoulas, D., Paoletti, S., Paolucci, P., Pascale, G., Passaleva, G., Patricelli, Sergio, Paul, T., Pauluzzi, M., Paus, C., Pauss, F., Pei, Y. J., Pensotti, S., Perretgallix, D., Petrak, S., Pevsner, A., Piccolo, D., Pieri, M., Pinto, J. C., Piroue, P. A., Pistolesi, E., Plyaskin, V., Pohl, M., Pojidaev, V., Postema, H., Produit, N., Raghavan, R., Rahalcallot, G., Rancoita, P. 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F., Suter, H., Swain, J. D., Tang, X. W., Tauscher, L., Taylor, L., S. C. C., Ting, S. M., Toker, O., Tonisch, F., Tonutti, M., Tonwar, S. C., Toth, J., Tsaregorodtsev, A., Tsipolitis, G., Tully, C., Tuchscherer, H., Ulbricht, J., Urban, L., Uwer, U., Valente, E., Vandewalle, R. T., Vetlitsky, I., Viertel, G., Vivargent, M., Volkert, R., Vogel, H., Vogt, H., Vorobiev, I., Vorobyov, A. A., Vuilleumier, L., Wadhwa, M., Wallraff, W., Wang, J. C., Wang, X. L., Wang, Y. F., Wang, Z. M., Weber, A., Weill, R., Willmott, C., Wittgenstein, F., S. X., Wu, Wynhoff, S., Xu, J., Z. Z., Xu, Yang, B. Z., Yang, C. G., Yao, X. Y., J. B., Ye, Yeh, S. C., You, J. M., Zaccardelli, C., Zalite, A., Zemp, P., Zeng, J. Y., Zeng, Y., Zhang, Z., Zhang, Z. P., Zhou, B., Zhou, G. J., Zhou, J. F., Zhou, Y., Zhu, G. Y., Zhu, R. Y., Zichichi, A., and B. C. C.

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Meson, 010308 nuclear & particles physics, Higgs boson, L3 experiment, Hadron, Física, large electron positron collider, MESONS, 01 natural sciences, CP-VIOLATION, TheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY, 0103 physical sciences, Large Electron–Positron Collider, High Energy Physics::Experiment, Atomic physics, Nuclear Experiment, 010306 general physics, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Particle Physics - Experiment, Ciencias Exactas, L3 EXPERIMENT
Abstract

A search for rare charmless decays of B0d and B0s mesons has been performed in the exclusive channels B0d(s) →ηη0, B0d(s) →ηπ0 and B0d(s) →π0π0. The data sample consisted of three million hadronic Z decays collected by the L3 experiment at LEP from 1991 through 1994. No candidate event has been observed and the following upper limits at 90% confidence level on the branching ratios have been set: Br(B0d→ηη) −4, Br(B0s →ηη) < 1.5 x 10−3, Br(B0d→ηπ0) < 2.5 x 10−4, Br(B0s→ηπ0) < 1.0 x 10−3, Br(B0d→π0π0) < 6.0 x 10−5, Br(B0s→π0π0) < 2.1 x 10−4. These are the first experimental limits on Bd0→ηη and on the Bs0 neutral charmless modes., Facultad de Ciencias Exactas

Published
2016

19. Functional anatomy of the mammalian sperm flagellum

Author

Charles B, Lindemann and Kathleen A, Lesich

Subjects
Male, Axoneme, Sperm Tail, Sperm Motility, Animals, Dyneins, Humans, Basal Bodies
Abstract

The eukaryotic flagellum is the organelle responsible for the propulsion of the male gamete in most animals. Without exception, sperm of all mammalian species use a flagellum for swimming. The mammalian sperm has a centrally located 9 + 2 arrangement of microtubule doublets and hundreds of accessory proteins that together constitute an axoneme. However, they also possess several characteristic peri-axonemal structures that make the mammalian sperm tail function differently. These modifications include nine outer dense fibers (ODFs) that are paired with the nine outer microtubule doublets of the axoneme, and are anchored in a structure called the connecting piece located at the base. The presence of the ODFs and connecting piece, and the absence of a basal body, dictate that physical forces generated by the dynein motors are transmitted to the base of the flagellum through the ODFs. Mammalian sperm flagella also possess a mitochondrial and a fibrous sheath that encircle most of the axoneme. These sheaths and the ODFs add mechanical rigidity to the flagellum creating the functional effect of increasing bend wavelength, which requires the entrainment of more dynein motors in the production of a single wave. The sheaths also act as a retinaculum and maintain the integrity of the central axoneme when large bending torques are generated by dynein. Large torque production is crucial to the process of hyperactivation and the unique motility transitions associated with effective fertilizing capacity. Consequently, these specialized anatomical features are essential for the effective interaction of sperm with the female reproductive tract and ovum. © 2016 Wiley Periodicals, Inc.

Published
2016

20. Functional Deficiencies and a Reduced Response to Calcium in the Flagellum of Mouse Sperm Lacking SPAG16L1

Author

Charles B. Lindemann, Zhibing Zhang, Kathleen A. Lesich, Courtney B. Kelsch, Jerome F. Strauss, and Kristen L. Ponichter

Subjects
Axoneme, Genetics, Hyperactivation, urogenital system, Dynein, Cell Biology, General Medicine, Microtubule sliding, Flagellum, Biology, Sperm, Cell biology, Reproductive Medicine, Sperm Midpiece, Sperm motility
Abstract

The Spag16L gene codes for a protein that is localized to the central apparatus which is essential for normal sperm motility and male fertility. Sperm from mice homozygous for a targeted deletion of the Spag16L gene were examined to assess their flagellar motor functions compared with age- and strain-matched control sperm. Sperm were also demembranated with Triton X-100 and examined for their ability to respond to free calcium, as well as for their ability to undergo microtubule sliding driven by dynein action. In addition, the passive flagella, inhibited by sodium metavanadate to disable the dyneins, were examined for mechanical abnormalities. Live Spag16L-null sperm exhibited much less bending of the flagellum during the beat. The amount of microtubule sliding in the R-bend direction of the beat was selectively restricted, which suggests that there is limited activation of the dyneins on one side of the axoneme in the live cells. This is corroborated by the results on detergent-extracted sperm models. The flagellar response to calcium is greatly reduced. The calcium response requires the activation of the dyneins on outer doublets 1, 2, 3, and 4. These are the same dyneins required for R-bend formation. In axonemes prepared to disintegrate by microtubule sliding, we observed little or no extrusion of doublets 1 and 2, consistent with a reduced activity of their dyneins. This deficit in motor function, and an increased rigidity of the midpiece region which we detected in the passive flagella, together can explain the observed motility characteristics of the Spag16L-null sperm.

Published
2010

21. Flagellar and ciliary beating: the proven and the possible

Author

Charles B. Lindemann and Kathleen A. Lesich

Subjects
Axoneme, Mechanism (biology), Molecular Motor Proteins, Movement, Dynein, Dyneins, Axonemal dynein, Context (language use), macromolecular substances, Cell Biology, Anatomy, Biology, Models, Biological, Motor protein, Flagella, Animals, Humans, Cilia, Flagellar axoneme, Ciliary beating, Neuroscience
Abstract

The working mechanism of the eukaryotic flagellar axoneme remains one of nature's most enduring puzzles. The basic mechanical operation of the axoneme is now a story that is fairly complete; however, the mechanism for coordinating the action of the dynein motor proteins to produce beating is still controversial. Although a full grasp of the dynein switching mechanism remains elusive, recent experimental reports provide new insights that might finally disclose the secrets of the beating mechanism: the special role of the inner dynein arms, especially dynein I1 and the dynein regulatory complex, the importance of the dynein microtubule-binding affinity at the stalk, and the role of bending in the selection of the active dynein group have all been implicated by major new evidence. This Commentary considers this new evidence in the context of various hypotheses of how axonemal dynein coordination might work.

Published
2010

22. Insights into the Mechanism of ADP Action on Flagellar Motility Derived from Studies on Bull Sperm

Author

Dominic W. Pelle, Kathleen A. Lesich, and Charles B. Lindemann

Subjects
Male, Sodium Vanadate, Dynein, Biophysics, Beat (acoustics), Biology, Flagellum, Models, Biological, chemistry.chemical_compound, Animals, Computer Simulation, Flagellar motility, Sperm motility, Dose-Response Relationship, Drug, urogenital system, Spermatozoa, Sperm, Adenosine Diphosphate, Adenosine diphosphate, Torque, chemistry, Biochemistry, Flagella, Cell Biophysics, Sperm Motility, Cattle
Abstract

Adenosine diphosphate (ADP) is known to have interesting effects on flagellar motility. Permeabilized and reactivated bull sperm exhibit a marked reduction in beating frequency and a greatly increased beat amplitude in the presence of 1-4 mM ADP. In this study we examined the force production of sperm reactivated with 0.1 mM ATP with and without 1 mM ADP and found that there is little or no resulting change in the stalling force produced by a bull sperm flagella in response to ADP. Because bull sperm bend to a higher curvature after ADP treatment we explored the possibility that ADP-treated sperm flagella are more flexible. We measured the stiffness of 50 mM sodium vanadate treated bull sperm in the presence of 4 mM ADP, but found no change in the passive flagellar stiffness. When we analyzed the torque that develops in ADP-treated sperm at the point of beat reversal we found that the torque developed by the flagellum is significantly increased. Our torque estimates also allow us to calculate the transverse force (t-force) acting on the flagellum at the point of beat direction reversal. We find that the t-force at the switch-point of the beat is increased significantly in the ADP treated condition, averaging 0.7 6 0.29 nN/m mi n 0.1 mM ATP and increasing to 2.9 6 1.2 nN/mm in 0.1 mM ATP plus 4 mM ADP. This suggests that ADP is exerting its effect on the beat by increasing the tenacity of dynein attachment at the B-subtubule. This could be a direct result of a regulatory effect of ADP on the binding affinity of dynein for the B-subtubule of the outer doublets. This result could also help to explain a number of previous experimental observations, as discussed. duced (7). These results suggest that the reduced beating frequency in ADP-treated sperm could be explained by a reductioninthevelocityofmicrotubuleslidinginADP-treated flagella. Paradoxically, Yagi (8) reported that inner arm dyneins actually improve their ability to translocate micro- tubules in the presence of ADP as compared to ATP alone. In line with this it has also been reported that the completeness of the disintegration is actually increased in the presence of ADP (9). This seems, at least superficially, to counter the slowing action of ADP on intact doublet sliding rates, and suggests amechanism bywhich aselective effect ontheinner arms could actually have a strengthening effect on beating amplitude and a positive effect on coordinated beating.

Published
2008
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23. Evidence for axonemal distortion during the flagellar beat ofChlamydomonas

Author

Charles B. Lindemann and David R. G. Mitchell

Subjects
Axoneme, biology, Movement, Cilium, Chlamydomonas, Bent molecular geometry, Dynein, Dyneins, Beat (acoustics), Cell Biology, Anatomy, Flagellum, biology.organism_classification, Models, Biological, Biomechanical Phenomena, Microscopy, Electron, Transmission, Radial spoke, Flagella, Structural Biology, Biophysics, Animals, Computer Simulation
Abstract

In order to understand the working mechanism that governs the flagellar beat it is essential to know if the axoneme undergoes distortion during the course of the beat cycle. The rapid fixation method employed by Mitchell was able to preserve the waveform of Chlamydomonas flagella much as it appears during normal flagellar beating [Mitchell, Cell Motil Cytoskeleton 2003;56:120-129]. This conservation of the waveform suggests that the stress responsible for the production of bending is also trapped by the fixation procedure. Longitudinal sections of these well-preserved flagella were used to document variations in the relative axonemal diameter. Sections aligned to the plane of bending, showing both the central pair microtubules and outer doublets, were examined for this purpose. Micrographs were selected that continuously showed both the outer doublets and the central pair from a straight region to a curved region of the flagellum. Axoneme diameters measured from these select micrographs showed an increase in relative diameter that averaged 39 nm greater at the crest of the bent region. This constituted a 24% increase in the axoneme diameter in the bends. The transverse stress acting across the axoneme during bending was calculated from the Geometric Clutch computer model for a simulated Chlamydomonas-like flagellar beat. If we assume that this is representative of the transverse stress acting in a real flagellum, then the Young's modulus of the intact axoneme is approximately 0.02 MPa. The possibility that the distortion of the axoneme during the beat could play a significant role in regulating dynein function is discussed.

Published
2007

24. Mechanics of the eukaryotic flagellar axoneme: Evidence for structural distortion during bending

Author

Dominic W. Pelle, Charles B. Lindemann, Kathleen A. Lesich, and Tania G. dePinho

Subjects
0301 basic medicine, Axoneme, Male, Flexibility (anatomy), urogenital system, Cell Biology, Mechanics, Bending, Flagellum, Biology, Curvature, Compression (physics), Models, Biological, Shear (sheet metal), 03 medical and health sciences, 030104 developmental biology, medicine.anatomical_structure, Radial spoke, Structural Biology, Sea Urchins, Sperm Tail, medicine, Sperm Motility, Animals
Abstract

The sliding doublet mechanism is the established explanation that allows us to understand the process of ciliary and flagellar bending. In this study, we apply the principles of the sliding doublet mechanism to analyze the mechanics of the counterbend phenomenon in sea urchin sperm flagella. When a passive, vanadate-treated, flagellum is forced into a bend with a glass microprobe, the portion of the flagellum distal to the probe exhibits a bend of opposite curvature (counterbend) to the imposed bend. This phenomenon was shown to be caused by the induction of inter-doublet shear and is dependent on the presence of an inter-doublet shear resistance. Here we report that in sea urchin flagella there is systematically less shear induced in the distal flagellum than is predicted by the sliding doublet mechanism, if we follow the assumption that the diameter of the flagellum is uniform. To account for the reduced shear that is observed, the likeliest and most direct interpretation is that the portion of the axoneme that is forced to bend undergoes substantial compression of the axoneme in the bending plane. A compression of 30-50 nm would be sufficient to account for the shear reduction from a bend of 2 radians. A compression of this magnitude would require considerable flexibility in the axoneme structure. This would necessitate that the radial spokes and/or the central pair apparatus are easily compressed by transverse stress. © 2016 Wiley Periodicals, Inc.

Published
2015

25. Insufficient evidence for changing editorial policy

Author

W. B. Lindemann

Subjects
Advanced and Specialized Nursing, 020205 medical informatics, business.industry, Publications, Health Informatics, 02 engineering and technology, Public administration, 03 medical and health sciences, 0302 clinical medicine, Health Information Management, 0202 electrical engineering, electronic engineering, information engineering, Medicine, 030212 general & internal medicine, business, Medical Informatics, Research Article
Published
2015

26. A follow-up study on fall and fracture incidence in long-term care including the role of formal caregiver time on fall incidence rates

Author

Clemens Becker, Thorsten Nikolaus, Kilian Rapp, Ulrich Rißmann, B. Lindemann, Martina Kron, and Sabine Loy

Subjects
Male, medicine.medical_specialty, Time Factors, Health (social science), Injury control, Accident prevention, Nurses, Poison control, Fractures, Bone, Confidence Intervals, Humans, Medicine, Aged, Quality of Health Care, Aged, 80 and over, Gynecology, Hip Fractures, business.industry, Geriatrics gerontology, Incidence, Incidence (epidemiology), Age Factors, Follow up studies, Middle Aged, Long-Term Care, Nursing Homes, Surgery, Issues, ethics and legal aspects, Data Interpretation, Statistical, Accidental Falls, Female, Nursing Care, Geriatrics and Gerontology, business, Femoral Fractures, Gerontology, Follow-Up Studies
Abstract

Untersuchung des Effekts eines Sturzpraventionsprogramms im Pflegeheimbereich in den 12 Verlaufsmonaten nach Abschluss der kontrollierten Phase unter Beteiligung der Warteeinrichtungen. Beschreibung der Inzidenzdichteraten der Ereignisse unter Beachtung der Pflegezeit im Vergleich von Werktagen und Wochenenden. Prospektive zwolfmonatige Beobachtungsstudie. Sechs Pflegeeinrichtungen einer Stadt in Suddeutschland. 881 Heimbewohner (771 Bewohnerjahre), Altersmedian 85,0 (Min. 60, Max. 101) davon 79,1% Frauen. Inzidenzdichteraten der Sturze und Frakturen, verfugbare Arbeitszeit der Pflegemitarbeiter. Die Inzidenzdichterate lag bei 1367/1000 Bewohnerjahre (BJ) fur Sturze [95% Konfidenzintervall (KI) 1041;1693]. Die Inzidenzdichterate der PFF lag bei 29/1000 BJ [95% KI 12;45] and 29/1000 BJ [95% KI 12;45] fur andere Frakturen. Die Inzidenzdichteraten zeigten vergleichbare Zahlen an Wochentagen und Wochenenden sowohl bei Sturzen 1193 vs. 1447/ 1000 BJ; Huftfrakturen 25 vs. 30/ 1000 BJ und bei anderen Frakturen 16 vs. 34/1000 RY. Im Beobachtungszeitraum kam es zu einem deutlichen Ruckgang der Frakturraten gegenuber dem Zeitraum der kontrollierten Phase der Interventionsstudie. Eine niedrige Arbeitszeit am Wochenende und an Feiertagen war nicht mit einer erhohten Sturz- und Frakturhaufigkeit verbunden

Published
2006

27. Medizin im Altenheim

Author

B. Lindemann, Clemens Becker, P. Koczy, and Ulrich Rissmann

Subjects
Issues, ethics and legal aspects, Health (social science), business.industry, Medicine, Geriatrics and Gerontology, business, Gerontology
Published
2005

28. Testing the Geometric Clutch hypothesis

Author

Charles B. Lindemann

Subjects
Male, Axoneme, Nexin, biology, urogenital system, Cilium, Shear force, Dynein, Dyneins, Cell Biology, General Medicine, Mechanics, Anatomy, Flagellum, Models, Biological, Spermatozoa, Transverse plane, Flagella, biology.protein, Animals, Cattle, Clutch, Cilia
Abstract

The Geometric Clutch hypothesis is based on the premise that transverse forces (t-forces) acting on the outer doublets of the eukaryotic axoneme coordinate the action of the dynein motors to produce flagellar and ciliary beating. T-forces result from tension and compression on the outer doublets when a bend is present on the flagellum or cilium. The t-force acts to pry the doublets apart in an active bend, and push the doublets together when the flagellum is passively bent and thus could engage and disengage the dynein motors. Computed simulations of this working mechanism have reproduced the beating pattern of simple cilia and flagella, and of mammalian sperm. Cilia-like beating, with a clearly defined effective and recovery stroke, can be generated using one uniformly applied switching algorithm. When the mechanical properties and dimensions appropriate to a specific flagellum are incorporated into the model the same algorithm can simulate a sea urchin or bull sperm-like beat. The computed model reproduces many of the observed behaviors of real flagella and cilia. The model can duplicate the results of outer arm extraction experiments in cilia and predicted two types of arrest behavior that were verified experimentally in bull sperm. It also successfully predicted the experimentally determined nexin elasticity. Calculations based on live and reactivated sea urchin and bull sperm yielded a value of 0.5 nN/µm for the t-force at the switch-point. This is a force sufficient to overcome the shearing force generated by all the dyneins on one micron of outer doublet. A t-force of this magnitude should produce substantial distortion of the axoneme at the switch-point, especially in spoke or spoke-head deficient motile flagella. This concrete and verifiable prediction is within the grasp of recent advances in imaging technology, specifically cryoelectron microscopy and atomic force microscopy. © 2004 Elsevier SAS. All rights reserved.

Published
2004

29. Morphometric relationships between tooth and face shapes

Author

Pfeiffer P, H.-B. Lindemann, and Christian Knauer

Subjects
Adult, Male, Similarity (geometry), Adolescent, Cephalometry, Eyebrow, Dentistry, Statistics, Nonparametric, Face shape, Clinical study, Sex Factors, Maxilla, Photography, medicine, Humans, Odontometry, Maxillary central incisor, General Dentistry, Aged, Mathematics, business.industry, Middle Aged, Chin, Incisor, medicine.anatomical_structure, Hausdorff distance, Face, Face (geometry), Female, business, Algorithms
Abstract

summary The shape of a patient's face is commonly used as a reference to select the shape of the maxillary central incisors in edentulous patients. The validity of this relationship has not been proved. The objective of this clinical study was to determine whether a relationship exists between maxillary central incisors and face shapes. Casts were made of the maxillas of 50 men and 50 women. A standardized digital photographic procedure was used to record frontal views of each subject's face and of the maxillary central incisors of the dental casts. The shapes of the maxillary central incisors were compared with the face forms. Shape matches were evaluated according to their Hausdorff distance (HDD). The function h(A,B) is called the directed HDD from shape A to shape B (this function is not a true distance). It reflects the distance of the point of shape A that is farthest from any point of shape B and vice versa. The similarity of both shapes is given as a non-negative number. The value 0·0 indicates that the figures are identical (after scaling and shifting). Higher values indicate that shapes differ more substantially. Significant differences on the 5% level were calculated using the non-parametric Mann–Whitney U and Kruskal–Wallis tests. The face shape from the chin margin to the eyebrow line (superior edges of the eyebrows) produced a better match than the one from the chin to the hairline (P

Published
2004

30. Does axonemal dynein push, pull, or oscillate?

Author

Charles B. Lindemann and Alan J. Hunt

Subjects
Axoneme, Protein Conformation, Molecular Motor Proteins, Cilium, Dynein, Dyneins, macromolecular substances, Cell Biology, Anatomy, Biology, Flagellum, Microtubules, Adenosine Triphosphate, Flagella, Structural Biology, Microtubule, ATP hydrolysis, Molecular motor, Biophysics, Animals, Cilia, Cytoskeleton
Abstract

Dynein is the molecular motor that provides motive force in cilia and flagella. Dynein is anchored to the A-subtubule of the outer doublets by a club-shaped extension called the stem, which supports the large globular head of the molecule. Dynein forms an attachment or cross-bridge to the B-subtubule of the adjacent outer doublet through a slender appendage extending from the head that is called the stalk or alternately the B-link. It is generally thought that the B-link mediates the interdoublet transfer of force that bends the flagellum. This requires that energy released at the site of ATP hydrolysis, located in the globular head, be transferred as mechanical work to the microtubule binding site at the tip of the B-link. It has been proposed that this is accomplished by a sideways or rotational translocation of the B-link caused by a rotation of the globular head. An estimate of the stiffness of the B-link and stem derived from the recently published data of Burgess et al. [2003: Nature 421:715–718] yields a maximum stiffness of 0.47 pN/nm for the B-link and 0.1 pN/nm for the stem. The B-link stiffness would allow transfer of 3.8 pN of force in response to an 8-nm displacement of the B-link tip. However, if as proposed the globular head of the dynein heavy chain is supported by the stem, the B-link and stem elasticity are in series. Thus, the flexibility of the stem would limit the force that can be transferred laterally by the entire dynein heavy chain to 0.6 pN at 8 nm displacement. This force is insufficient to support flagellar motility. So, if the stem were the only support for the globular head, then force would have to be transmitted linearly along the axis defined by the stem and B-link. Because this configuration is never observed, the hypothesis that dynein generates force by lateral displacement of the B-link is more attractive, but requires that the globular head of the dynein is stabilized by an additional means of support during the power stroke. We propose that the microtubule affinity of the tip of the B-link is independent of the ATP-dependent powerstroke, and that detachment from the B-subtubule is regulated by tension. A dynein cross-bridge cycle that incorporates an anchored head, together with a ratchet-like mechanism for microtubule translocation by the B-link, would have distinct advantages. This mechanism may reconcile dynein oscillation and interdoublet sliding within one cross-bridge mechanism. Cell Motil. Cytoskeleton 56:237–244, 2003. © 2003 Wiley-Liss, Inc.

Published
2003

31. F�higkeiten und Einschr�nkungen von Heimbewohnern

Author

B. Eichner, Thorsten Nikolaus, B. Lindemann, Clemens Becker, Martina Kron, Ulrich Rissmann, and E. Sturm

Subjects
Minimum Data Set, medicine.medical_specialty, Health (social science), business.industry, MEDLINE, Urinary incontinence, medicine.disease, Issues, ethics and legal aspects, Family medicine, Cohort, medicine, Dementia, Geriatrics and Gerontology, medicine.symptom, Nursing Minimum Data Set, business, Gerontology, Body mass index, Stroke
Abstract

UNLABELLED The main objective of the study was to examine the prevalence of problems and resources of an unselected cohort of nursing home residents. The sample includes residents (n=769) of an urban area in Southern Germany. The assessment definitions were used according to the Minimum Data Set of the Resident Assessment Instruments (Version 2.0). RESULTS The mean age was 84.2 years, 608 of the residents were female. Dementia (446) and stroke (185) were the most common main diagnosis. Syndrome prevalences are reported for depressive symptoms (323), mobility impairments (608), urinary incontinence (461), decubitus (54), use of restraints (54), disruptive behavior (185), psychopharmacy (377), severe visual impairment (123) and severe hearing impairment (123).

Published
2003

32. Structural-Functional Relationships of the Dynein, Spokes, and Central-Pair Projections Predicted from an Analysis of the Forces Acting within a Flagellum

Author

Charles B. Lindemann

Subjects
Male, Axoneme, Protein Conformation, Dynein, Biophysics, Flagellum, Biology, Microtubules, Models, Biological, Motor protein, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Protein structure, Species Specificity, Radial spoke, Cell Movement, Microtubule, Animals, Computer Simulation, 030304 developmental biology, 0303 health sciences, urogenital system, Molecular Motor Proteins, Dyneins, Anatomy, Elasticity, Transverse plane, Flagella, Cell Biophysics, Sea Urchins, Sperm Tail, Cattle, Stress, Mechanical, 030217 neurology & neurosurgery
Abstract

In the axoneme of eukaryotic flagella the dynein motor proteins form crossbridges between the outer doublet microtubules. These motor proteins generate force that accumulates as linear tension, or compression, on the doublets. When tension or compression is present on a curved microtubule, a force per unit length develops in the plane of bending and is transverse to the long axis of the microtubule. This transverse force (t-force) is evaluated here using available experimental evidence from sea urchin sperm and bull sperm. At or near the switch point for beat reversal, the t-force is in the range of 0.25-1.0 nN/ micro m, with 0.5 nN/ micro m the most likely value. This is the case in both beating and arrested bull sperm and in beating sea urchin sperm. The total force that can be generated (or resisted) by all the dyneins on one micron of outer doublet is also approximately 0.5 nN. The equivalence of the maximum dynein force/ micro m and t-force/ micro m at the switch point may have important consequences. Firstly, the t-force acting on the doublets near the switch point of the flagellar beat is sufficiently strong that it could terminate the action of the dyneins directly by strongly favoring the detached state and precipitating a cascade of detachment from the adjacent doublet. Secondly, after dynein release occurs, the radial spokes and central-pair apparatus are the structures that must carry the t-force. The spokes attached to the central-pair projections will bear most of the load. The central-pair projections are well-positioned for this role, and they are suitably configured to regulate the amount of axoneme distortion that occurs during switching. However, to fulfill this role without preventing flagellar bend formation, moveable attachments that behave like processive motor proteins must mediate the attachment between the spoke heads and the central-pair structure.

Published
2003

33. Determination of alpha-s from hadronic event shapes measured on the Z0 resonance

Author

B. Monteleoni, F. Sticozzi, C. Spartiotis, R. Morand, Z. L. Xue, Howard A. Stone, Roberto Battiston, Gerjan Bobbink, B. Borgia, J. Ulbricht, I. Clare, J. Busenitz, P. Göttlicher, J. M. Salicio, A. Arefiev, A. Kasser, Guofan Hu, C. Neyer, R. Mount, V. Plyaskin, Y. J. Pei, Raffaello D'Alessandro, M. Vivargent, Stefan Kirsch, B. N. Jin, M. Sachwitz, C. Grinnell, A. M. Cartacci, R. Raghavan, H. Nowak, Z. F. Gong, H. Anderhub, T. E. Coan, J. G. Branson, H. R. Gustafson, U. Herten, M. Bocciolini, M. T. Dova, D.N. Mao, Leonardo Merola, A. C. König, Laurent Vuilleumier, Y. H. Chang, Z. W. Yin, S. N. Ganguli, H. O. Cohn, F. Marzano, G. Coignet, W. Krenz, M. N. Kienzle-Focacci, R. Rosmalen, W. Wallraff, George Alverson, A. Degré, An.A. Vorobyov, T. Matsuda, A. Tsaregorodtsev, J. S. Kapustinsky, M. Gailloud, S. Banerjee, Yongqing Wu, E. Sajan, Samuel C.C. Ting, X. T. Cui, T. Kramer, J. J. Blaising, Tariq Aziz, R. Barillère, T. Azemoon, P. Schmitz, Lucas Taylor, Steven Goldfarb, M. Caria, Steven Ahlen, R. L. Sumner, G. H. Wang, W. Kittel, S. Schulte, K. Schmiemann, Dimitri Bourilkov, A. Koulbardis, D. Linnhofer, G. Herten, Federico Carminati, K. Freudenreich, D. Gele, E. Nagy, J. Wenninger, V. Pojidaev, Marcos Cerrada, W. Friebel, G. M. Bilei, M. Fabre, M. Schneegans, O. Adrian, Yu. Kamyshkov, N. E. Moulai, D. M. Lee, P. Zemp, Mw Gruenewald, V. Koutsenko, E. Fiandrini, Mariagrazia Alviggi, Andrea Contin, D. P. Stickland, S. X. Wu, G. B. Mills, Crisostomo Sciacca, Marco Pieri, D. Z. Shen, J. A. Bakken, J.P. Burq, R. de Asmundis, Y. Mir, C. H. Ye, M. Möller, S. Patricelli, M. Sassowsky, R. Fabbretti, C. G. Yang, G. Sauvage, R.B. Sutton, D. DiBitonto, Yu. Galaktionov, J. Alcaraz, Ph. Rosselet, Atul Gurtu, K. Deiters, M. Steuer, Q. Ye, Wen-Gan Ma, C. Maña, I. Vetlitsky, K. S. Kumar, G. Forconi, Alberto Aloisio, Harvey B Newman, K. Hilgers, H. F. Chen, J. D. Burger, J. Weber, G. Rahal-Callot, D. Fernandez, D. Perret-Gallix, A. Ricker, Yanwen Liu, Adrian Biland, B. P. Roe, W. Y. Chen, Th. Meinholz, B. Zhou, Cheng Chen, W. J. Burger, Sabine Riemann, S. J. Fan, X. W. Tang, I. Sheer, P. A. Piroué, C. Zaccardelli, F. Ferroni, B. C.C. van der Zwaan, W. W. Kinnison, G. Chiefari, S. Shevchenko, K. Schultze, H. Suter, A. Bujak, Oliver Kornadt, M. Pohl, Y. Zeng, A. Krivshich, F. Behner, Pablo Garcia-Abia, Alain Hervé, T. Angelov, D. Lanske, Sc Yeh, R. Malik, L. Romero, H. El Mamouni, A. Engler, I. C. Brock, A. Bay, Wt Lin, J. M. Lubbers, Jianming Qian, G. Hu, B. L. Betev, Carlo Civinini, M. Maolinbay, G. Raven, M. Bourquin, K. Strauch, J. C. Sens, P. Arce, D. Goujon, N. Yunus, G. Gratta, M. Aguilar-Benitez, H. S. Fesefeldt, Egidio Longo, Herwig Schopper, M. White, Zhuoxiang Ren, Carlos Willmott, M. Wadhwa, D. J. Schotanus, J. M. You, Vincenzo Innocente, S. Röhner, Speranza Falciano, Y. F. Wang, N. Produit, V. R. Krastev, F. Wittgenstein, L. Ludovici, M. Chmeissani, H. T. Li, D. Antreasyan, E. Drago, G. A. Yang, L. Niessen, A. Sopczak, L. J. Gutay, Ren-Yuan Zhu, Luciano Barone, Qi An, U. Becker, A. Marin, T. Driever, M. M. Ilyas, A. A. Syed, H. Janssen, Jiunn-Wei Chen, I. Duran, K.S. Yang, M. Rescigno, P. Kapinos, B.C. Stringfellow, H. R. Dimitrov, O. Fackler, L. Urbán, P. Duinker, F. J. Eppling, L. W. Jones, D. S. Yan, M. Yzerman, F. Crijns, S. M. Ting, A. Klimentov, Jun Guo, B. Lindemann, G. Passaleva, E. Dénes, R. Sehgal, G. Finocchiaro, Kenneth Francis Read, Q.Y. Yang, L. Z. Sun, D. Hauschildt, Marcel Merk, J. Perrier, Els Koffeman, R. Weill, C-Q. Li, Yuehong Xie, Christine Buisson, S. S. Gau, T. J. Wenaus, V. K. Gupta, A. L. Anderson, F. Marion, H. J. Schreiber, J. F. Zhou, M. MacDermott, P.V.K.S. Baba, H. L. Zhuang, M. A. Niaz, E. Brambilla, R. Bizzarri, F. DeNotaristefani, A. Hasan, Y. D. Xu, F. Cesaroni, J. Y. Liao, Emilio Leonardi, J. Schütte, P. Berges, R. Bock, L. Baksay, U. K. Chaturvedi, Y. S. Lu, M. Fukushima, M. Lenti, A. Nadtochy, Xiaoli Li, D. Duchesneau, J. M. Le Goff, D. H. Wright, G. S. Sanders, P. G. Seiler, J. A. Rubio, A. Malinin, Jérôme Rose, Kajari Mazumdar, S. Khokhar, T.R. McMahon, X. J. Yan, S. Müller, X. L. Wang, Xd Cai, J. H. Field, C. Y. Chien, J. Behrens, P. J. Li, P. Lebrun, BT Bouwens, U. Uwer, A. Chen, J. Salicio, Maurizio Biasini, Marta Felcini, Francesco Becattini, M. Capell, J. Krizmanic, Valery Schegelsky, Antonino Zichichi, Ph Fisher, H. Rykaczewski, Giovanni Organtini, Y. Karyotakis, E. Gonzalez, S. Chung, Attilio Santocchia, Jean Fay, M. Dhina, D. Boutigny, S. Lanzano, P. Vikas, G. Tsipolitis, Z. Y. Lin, L. Antonov, K. Sudhakar, J.H. Wang, Zhongyukun Xu, P. K. Malhotra, H. A. Rizvi, Y. Mi, J. B. Ye, A. Kunin, Gerard Fernandez, F. Plasil, Mingshui Chen, Hafeez R Hoorani, Jozsef Toth, J. Lettry, Elisabetta Gallo, M. Pauluzzi, Chenliang Wang, S. Reucroft, S. Shotkin, W. J. Metzger, D. Ren, S. C. Tonwar, J. Shukla, M. S. Sarakinos, M.L. Chen, U. Vikas, Frank Filthaut, Marcella Diemoz, M. Guanziroli, Zheng Wang, Giovanni Ambrosi, J. P. Martin, Zhenyu Zhang, E. Valente, D. McNally, A. C. Weber, Bolek Wyslouch, Qian Wang, E. Shumilov, X. R. Shi, V. Shoutko, X. Leytens, G. Viertel, Felicitas Pauss, Chenjie Gu, C. F. He, Marco Meschini, P. Extermann, G. Mirabelli, I. Leedom, B. Z. Yang, H. Hofer, K. L. Tung, S. Rosier-Lees, Hans J. Vogel, S. Morganti, D. Kirkby, D.W. Schmitz, P. Le Coultre, M. Tonutti, J. Schwenke, K. N. Qureshi, G.G.G. Massaro, A. Pevsner, K. Lübelsmeyer, Piero Spillantini, X. Y. Cui, Igor Vorobiev, Claudio Luci, S. Beingessner, Robert Clare, Barry Blumenfeld, Thomas Hebbeker, Paul Lecoq, R. W. Kraemer, K. Hangarter, M. Napolitano, M. Hebert, E. Soderstrom, H. S. Chen, L. Servoli, L. Martinez-Laso, Panos A Razis, J. Mnich, A. Atamanchuk, P. Marchesini, R. Starosta, P. Blömeke, D. Luckey, Gy L. Bencze, A. Rubbia, T. Foreman, Ming Zeng, Reinhard W. Schulte, M. Röhner, Christopher George Tully, Stéphane Jézéquel, J. Bao, F. C. Erné, Simonetta Gentile, R.J. Wu, J. Berdugo, Y.F. Mao, Z.Q. Yang, R. T. Van de Walle, Lamberto Luminari, G. Schwering, Wolfgang Lohmann, H. Vogt, B. Bertucci, I. Scott, Nicanor Colino, G. Landi, M. L. Brooks, R. C. Ball, Simone Paoletti, O. Rind, Pierre Lecomte, G. Sartorelli, Charles Timmermans, Manjit Kaur, C. Dionisi, D. Pandoulas, Georgi Sultanov, Fl Linde, T. S. Dai, R. A. Khan, T. Spickermann, V. P. Andreev, Daqiang Zhang, Bernard Ille, M. Chemarin, G. M. Chen, Peter Denes, Paolo Bagnaia, J. D. Swain, P. McBride, T. Fergusson, A. Böhm, R. Leiste, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), CMS, Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), L3, O., Adriani, M., Aguilarbenitez, S., Ahlen, H., Akbari, J., Alcaraz, Aloisio, Alberto, G., Alverson, Alviggi, Mariagrazia, G., Ambrosi, Q., An, H., Anderhub, A. L., Anderson, V. P., Andreev, T., Angelov, L., Antonov, D., Antreasyan, P., Arce, A., Arefiev, A., Atamanchuk, T., Azemoon, T., Aziz, P. V., K., P., Bagnaia, J. A., Bakken, L., Baksay, R. C., Ball, S., Banerjee, J., Bao, R., Barillere, L., Barone, R., Battiston, A., Bay, F., Becattini, U., Becker, F., Behner, J., Behren, S., Beingessner, G. L., Bencze, J., Berdugo, P., Berge, B., Bertucci, B. L., Betev, M., Biasini, A., Biland, G. M., Bilei, R., Bizzarri, J. J., Blaising, P., Blomeke, B., Blumenfeld, G. J., Bobbink, M., Bocciolini, R., Bock, A., Bohm, B., Borgia, D., Bourilkov, M., Bourquin, D., Boutigny, B., Bouwen, E., Brambilla, J. G., Branson, I. C., Brock, M., Brook, C., Buisson, A., Bujak, J. D., Burger, W. J., Burger, J. P., Burq, J., Busenitz, X. D., Cai, M., Capell, M., Caria, F., Carminati, A. M., Cartacci, M., Cerrada, F., Cesaroni, Y. H., Chang, U. K., Chaturvedi, M., Chemarin, A., Chen, C., Chen, G. M., Chen, H. F., Chen, H. S., Chen, J., Chen, M., Chen, M. L., Chen, W. Y., Chen, Chiefari, Giovanni, C. Y., Chien, M., Chmeissani, S., Chung, C., Civinini, I., Clare, R., Clare, T. E., Coan, H. O., Cohn, G., Coignet, N., Colino, A., Contin, F., Crijn, X. T., Cui, X. Y., Cui, T. S., Dai, R., Dalessandro, R., Deasmundi, A., Degre, K., Deiter, E., Dene, P., Dene, F., Denotaristefani, M., Dhina, D., Dibitonto, M., Diemoz, H. R., Dimitrov, C., Dionisi, M. T., Dova, E., Drago, T., Driever, D., Duchesneau, P., Duinker, I., Duran, H., Elmamouni, A., Engler, F. J., Eppling, F. C., Erne, P., Extermann, R., Fabbretti, M., Fabre, S., Falciano, S. J., Fan, O., Fackler, J., Fay, M., Felcini, T., Ferguson, D., Fernandez, G., Fernandez, F., Ferroni, H., Fesefeldt, E., Fiandrini, J., Field, F., Filthaut, G., Finocchiaro, P. H., Fisher, G., Forconi, T., Foreman, K., Freudenreich, W., Friebel, M., Fukushima, M., Gailloud, Y., Galaktionov, E., Gallo, S. N., Ganguli, P., Garciaabia, S. S., Gau, D., Gele, S., Gentile, S., Goldfarb, Z. F., Gong, E., Gonzalez, P., Gottlicher, D., Goujon, G., Gratta, C., Grinnell, M., Gruenewald, C., Gu, M., Guanziroli, J. K., Guo, V. K., Gupta, A., Gurtu, H. R., Gustafson, L. J., Gutay, K., Hangarter, A., Hasan, D., Hauschildt, C. F., He, T., Hebbeker, M., Hebert, G., Herten, U., Herten, A., Herve, K., Hilger, H., Hofer, H., Hoorani, G., Hu, G. Q., Hu, B., Ille, M. M., Ilya, V., Innocente, H., Janssen, S., Jezequel, B. N., Jin, L. W., Jone, A., Kasser, R. A., Khan, Y., Kamyshkov, P., Kapino, J. S., Kapustinsky, Y., Karyotaki, M., Kaur, S., Khokhar, M. N., Kienzlefocacci, W. W., Kinnison, D., Kirkby, S., Kirsch, W., Kittel, A., Klimentov, A. C., Konig, E., Koffeman, O., Kornadt, V., Koutsenko, A., Koulbardi, R. W., Kraemer, T., Kramer, V. R., Krastev, W., Krenz, A., Krivshich, J., Krizmanic, K. S., Kumar, A., Kunin, G., Landi, D., Lanske, S., Lanzano, P., Lebrun, P., Lecomte, P., Lecoq, P., Lecoultre, D. M., Lee, I., Leedom, J. M., Legoff, R., Leiste, M., Lenti, E., Leonardi, J., Lettry, X., Leyten, C., Li, H. T., Li, P. J., Li, X. G., Li, J. Y., Liao, W. T., Lin, Z. Y., Lin, F. L., Linde, B., Lindemann, D., Linnhofer, Y., Liu, W., Lohmann, E., Longo, Y. S., Lu, J. M., Lubber, K., Lubelsmeyer, C., Luci, D., Luckey, L., Ludovici, L., Luminari, W. G., Ma, M., Macdermott, P. K., Malhotra, R., Malik, A., Malinin, C., Mana, D. N., Mao, Y. F., Mao, M., Maolinbay, P., Marchesini, F., Marion, A., Marin, J. P., Martin, L., Martinezlaso, F., Marzano, G. G., G., T., Matsuda, K., Mazumdar, P., Mcbride, T., Mcmahon, D., Mcnally, T., Meinholz, M., Merk, Merola, Leonardo, M., Meschini, W. J., Metzger, Y., Mi, G. B., Mill, Y., Mir, G., Mirabelli, J., Mnich, M., Moller, B., Monteleoni, R., Morand, S., Morganti, N. E., Moulai, R., Mount, S., Muller, A., Nadtochy, E., Nagy, Napolitano, Marco, H., Newman, C., Neyer, M. A., Niaz, L., Niessen, H., Nowak, G., Organtini, D., Pandoula, S., Paoletti, G., Passaleva, Patricelli, Sergio, M., Pauluzzi, F., Pau, Y. J., Pei, D., Perretgallix, J., Perrier, A., Pevsner, M., Pieri, P. A., Piroue, F., Plasil, V., Plyaskin, M., Pohl, V., Pojidaev, N., Produit, J. M., Qian, K. N., Qureshi, R., Raghavan, G., Rahalcallot, G., Raven, P., Razi, K., Read, D., Ren, Z., Ren, M., Rescigno, S., Reucroft, A., Ricker, S., Riemann, O., Rind, H. A., Rizvi, B. P., Roe, M., Rohner, S., Rohner, L., Romero, J., Rose, S., Rosierlee, R., Rosmalen, P., Rosselet, A., Rubbia, J. A., Rubio, H., Rykaczewski, M., Sachwitz, E., Sajan, J., Salicio, J. M., Salicio, G. S., Sander, A., Santocchia, M. S., Sarakino, G., Sartorelli, M., Sassowsky, G., Sauvage, V., Schegelsky, K., Schmiemann, D., Schmitz, P., Schmitz, M., Schneegan, H., Schopper, D. J., Schotanu, S., Shotkin, H. J., Schreiber, J., Shukla, R., Schulte, S., Schulte, K., Schultze, J., Schutte, J., Schwenke, G., Schwering, Sciacca, Crisostomo, I., Scott, R., Sehgal, P. G., Seiler, J. C., Sen, L., Servoli, I., Sheer, D. Z., Shen, S., Shevchenko, X. R., Shi, E., Shumilov, V., Shoutko, E., Soderstrom, A., Sopczak, C., Spartioti, T., Spickermann, P., Spillantini, R., Starosta, M., Steuer, D. P., Stickland, F., Sticozzi, H., Stone, K., Strauch, B. C., Stringfellow, K., Sudhakar, G., Sultanov, R. L., Sumner, L. Z., Sun, H., Suter, R. B., Sutton, J. D., Swain, A. A., Syed, X. W., Tang, L., Taylor, C., Timmerman, S. C., C., S. M., Ting, M., Tonutti, S. C., Tonwar, J., Toth, A., Tsaregorodtsev, G., Tsipoliti, C., Tully, K. L., Tung, J., Ulbricht, L., Urban, U., Uwer, E., Valente, R. T., Vandewalle, I., Vetlitsky, G., Viertel, P., Vika, U., Vika, M., Vivargent, H., Vogel, H., Vogt, I., Vorobiev, A. A., Vorobyov, L., Vuilleumier, M., Wadhwa, W., Wallraff, C. R., Wang, G. H., Wang, J. H., Wang, Q. F., Wang, X. L., Wang, Y. F., Wang, Z. M., Wang, A., Weber, J., Weber, R., Weill, T. J., Wenau, J., Wenninger, M., White, C., Willmott, F., Wittgenstein, D., Wright, R. J., Wu, S. X., Wu, Y. G., Wu, B., Wyslouch, Y. Y., Xie, Y. D., Xu, Z. Z., Xu, Z. L., Xue, D. S., Yan, X. J., Yan, B. Z., Yang, C. G., Yang, G., Yang, K. S., Yang, Q. Y., Yang, Z. Q., Yang, C. H., Ye, J. B., Ye, Q., Ye, S. C., Yeh, Z. W., Yin, J. M., You, N., Yunu, M., Yzerman, C., Zaccardelli, P., Zemp, M., Zeng, Y., Zeng, D. H., Zhang, Z. P., Zhang, B., Zhou, J. F., Zhou, R. Y., Zhu, H. L., Zhuang, A., Zichichi, B. C., C., and IHEF (IoP, FNWI)

Subjects
Nuclear and High Energy Physics, Particle physics, LUND MONTE-CARLO, Electron–positron annihilation, TO-BACK JETS, Hadron, Jet (particle physics), 01 natural sciences, Resonance (particle physics), ELECTRON-POSITRON-ANNIHILATION, Nuclear physics, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Resummation, 010306 general physics, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Physics, Quantum chromodynamics, QUANTUM CHROMODYNAMICS, 010308 nuclear & particles physics, JET PRODUCTION-RATES, High Energy Physics::Phenomenology, E+E-ANNIHILATION, QCD, FREE PERTURBATION-THEORY, Hadronization, ENERGY CORRELATIONS, Experimental uncertainty analysis, High Energy Physics::Experiment, FRAGMENTATION, Particle Physics - Experiment
Abstract

We present a study of the global event shape variables thrust and heavy jet mass, of energy-energy correlations and of jet multiplicities based on 250 000 hadronic Z 0 decays. The data are compared to new QCD calculations including resummation of leading and next-to-leading logarithms to all orders. We determine the strong coupling constant α s (91.2 GeV) = 0.125±0.003 (exp) ± 0.008 (theor). The first error is the experimental uncertainty. The second error is due to hadronization uncertainties and approximations in the calculations of the higher order corrections.

Published
1992

34. Ultrastructural evidence that motility changes caused by variations in ATP, Mg2+ , and ADP correlate to conformational changes in reactivated bull sperm axonemes

Author

Kathleen A, Lesich, Tania G, de Pinho, Loan, Dang, and Charles B, Lindemann

Subjects
Adenosine Diphosphate, Male, Adenosine Triphosphate, Axoneme, Flagella, Sperm Motility, Animals, Dyneins, Cattle, Spermatozoa
Abstract

We report the results of an ultrastructural study of Triton X-100-extracted, Mg-adenosine triphosphate (ATP)-reactivated bull sperm. We utilized a rapid fixation method to look for differences in the flagellar apparatus that correlate to the state of motility of reactivated sperm models. In a companion article, we examined the motility characteristics induced in bull sperm models by varying the concentration ratio of ATP and Mg(2+) and the stabilizing effect of adenosine diphosphate (ADP) on coordinated beating. Based on the results of that report, we selected four dissimilar states that appeared to represent extremes. One reactivation condition produces vigorous motility similar to live sperm, another produces large amplitude, low frequency beating while the remaining two conditions produce small amplitude vibrations of the flagellum with little coordinated beating. Morphometric analysis of transmission electron micrographs of sperm from these four treatment conditions revealed statistically significant differences between the samples in regard to axoneme diameter, inter-microtubule doublet spacing, and outer dense fiber (ODF) spacing. Our results show that Mg(2+) decreases the axoneme diameter and reduces interdoublet spacing, while ATP, uncomplexed with Mg(2+) , had the opposite effect. We also provide supporting evidence that this may be due to Mg(2+) increasing, and ATP decreasing, the interdoublet adhesion of dynein. We also found that 4 mM ADP significantly increases the separation between the ODFs and the space between the ODFs and the central axoneme within the middle piece. We present a hypothetical explanation that is consistent with our results to explain how ATP, ADP, and Mg(2+) act to regulate the beat cycle. © 2014 Wiley Periodicals, Inc.

Published
2014

35. The physiological role of ADP and Mg2+ in maintaining a stable beat cycle in bull sperm

Author

Charles B, Lindemann, Tania G, dePinho, and Kathleen A, Lesich

Subjects
Adenosine Diphosphate, Male, Flagella, Sperm Motility, Animals, Dyneins, Cattle, Magnesium, Spermatozoa
Abstract

Sperm flagella derive their motive power from the motor protein dynein. In this study, we show that maintenance of the flagellar beat cycle in detergent-extracted bull sperm models is highly dependent on the ratio of Mg(2+) to adenosine triphosphate (ATP). An excess of either ATP un-complexed with Mg(2+) , or an excess of Mg(2+) without an equivalent concentration of ATP, results in the loss of beat amplitude and a reduced curvature development in the beat cycle. In addition, we find that adenosine diphosphate (ADP) can stabilize the beat cycle and permit rhythmic beating across a broader range of ATP and Mg(2+) concentrations. We provide evidence that suggests that when ATP is un-complexed with Mg(2+) , it disrupts the beat cycle by reducing dynein adhesion and thereby, reduces the transmission of dynein-generated force between the doublets. Excess Mg(2+) does not act by the same mechanism and induces a condition where the flagellum is more resistant to bending. This is consistent with the idea that high Mg(2+) stabilizes rigor bridges, and ATP reduces the microtubule binding affinity of dynein. Our results may explain how intact sperm are able to sustain coordinated flagellar beating under a wide range of metabolic conditions, as intact sperm produce ADP in direct proportion to their consumption of ATP.

Published
2014

36. Measurement of the force and torque produced in the calcium response of reactivated rat sperm flagella

Author

Kathleen A. Schmitz, Charles B. Lindemann, and Mark J. Moritz

Subjects
Male, Axoneme, Biology, Flagellum, Rats, Sprague-Dawley, Structural Biology, medicine, Animals, Torque, Cilia, Microscopy, Video, Sperm flagellum, Hyperactivation, Stiffness, Cell Biology, Anatomy, Dyne, musculoskeletal system, Spermatozoa, Sperm, Elasticity, Rats, Flagella, Biophysics, bacteria, Calcium, medicine.symptom
Abstract

Rat sperm that are demembranated with Triton X-100 and reactivated with Mg-ATP show a strong mechanical response to the presence of free calcium ion. At pCa4, the midpiece region of the flagellum develops a strong and sustained curvature that gives the cell the overall appearance of a fishhook [Lindemann and Goltz, 1988: Cell Motil. Cytoskeleton 10:420-431]. In the present study, the force and torque that maintain the calcium-induced hook have been examined quantitatively. In addition, full-length and shortened flagella were manipulated to evaluate the plasticity of the hooks and determined the critical length necessary for maintaining the curvature. The hooks were found to be highly resilient, returning to their original configuration (95%) after being straightened and released. The results from manipulating the shortened flagella suggest that the force holding the hook in the curved configuration is generated in the basal 60 microm of the flagellum. The force required to straighten the calcium-induced hooks was measured with force-calibrated glass microprobes, and the bending torque was calculated from the measured force. The force and torque required to straighten the flagellum were found to be proportional to the change in curvature of the hooked region of the flagellum, suggesting an elastic-like behavior. The average torque to open the hooks to a straight position was 2.6 (+/-1.4) x 10(-7) dyne x cm (2.6 x 10(-14) N x m) and the apparent stiffness was 4.3 (+/-1.3) x 10(-10) dyne x cm(2) (4.3 x 10(-19) N x m(2)). The stiffness of the hook was determined to be approximately one quarter the rigor stiffness of a rat sperm flagellum measured under comparable conditions.

Published
2001

37. Flagellar arrest behavior predicted by the geometric clutch model is confirmed experimentally by micromanipulation experiments on reactivated bull sperm

Author

Kathleen A. Schmitz, Dana L. Holcomb-Wygle, and Charles B. Lindemann

Subjects
Axoneme, urogenital system, Dynein, Beat (acoustics), Cell Biology, Anatomy, Flagellum, Biology, Curvature, Sperm, Transverse plane, Structural Biology, Biophysics, Clutch
Abstract

The central tenet of the Geometric Clutch hypothesis of flagellar beating is that the internal force transverse to the outer doublets (t-force) mediates the initiation and termination of episodes of dynein engagement. Therefore, if the development of an adequate t-force is prevented, then the dynein-switching necessary to complete a cycle of beating should fail. The dominant component of the t-force is the product of the longitudinal force on each outer doublet multiplied by the local curvature of the flagellum. In the present study, two separate strategies, blocking and clipping, were employed to limit the development of the t-force in Triton X-100 extracted bull sperm models. The blocking strategy used a bent glass microprobe to restrict the flagellum during a beat, preventing the development of curvature in the basal portion of the flagellum. The clipping strategy was designed to shorten the flagellum by clipping off distal segments of the flagellum with a glass microprobe. This limits the number of dyneins that can contribute to bending and consequently reduces the longitudinal force on the doublets. The blocking and clipping strategies both produced an arrest of the beat cycle consistent with predictions based on the Geometric Clutch hypothesis. Direct comparison of experimentally produced arrest behavior to the behavior of the Geometric Clutch computer model of a bull sperm yielded similar arrest patterns. The computer model duplicated the observed behavior using reasonable values for dynein force and flagellar stiffness. The experimental data derived from both blocking and clipping experiments are fully compatible with the Geometric Clutch hypothesis.

Published
1999

38. Occurrence of ENaC Subunit mRNA and Immunocytochemistry of the Channel Subunits in Taste Buds of the Rat Vallate Papillaa

Author

R. Bock, O. Kretz, B. Lindemann, and Pascal Barbry

Subjects
inorganic chemicals, Epithelial sodium channel, medicine.medical_specialty, Taste, Immunocytochemistry, Biology, Polymerase Chain Reaction, Sodium Channels, General Biochemistry, Genetics and Molecular Biology, Rats, Sprague-Dawley, Tongue, History and Philosophy of Science, Internal medicine, medicine, Animals, RNA, Messenger, Lingual papilla, Epithelial polarity, Messenger RNA, urogenital system, General Neuroscience, respiratory system, Taste Buds, Immunohistochemistry, Reverse transcriptase, Rats, Cell biology, Endocrinology, Oligonucleotide Probes, hormones, hormone substitutes, and hormone antagonists, Intracellular
Abstract

Epithelial Na+ channels (ENaCs) are thought to mediate the amiloride-blockable salt taste. The rat vallate papilla does not contribute to amiloride-blockable salt taste, yet the presence of ENaC-mRNA in this tissue has been reported. Is ENaC actually contained in the taste cells, or is it merely present in the supporting lingual epithelium? To avoid contamination by ENaC contained in the lingual epithelium, we physically isolated taste buds from the vallate papilla and used mRNA purification followed by reverse transcriptase polymerase chain reaction (RT-PCR) to investigate the presence of ENaC-type message in the isolated buds. mRNA of alpha-, beta- and gamma-subunits was detected, the alpha-signal being the strongest. These results provide first molecular evidence for the presence of ENaC subunits in taste buds that were isolated from the posterior tongue and were free of epithelial contamination. In addition, we used immunohistochemistry to show ENaC-like reactivity in posterior tongue taste cells. Interestingly, the immunoreactivity was not predominantly apical but was intracellular and close to or at the basolateral membrane. The function of basolateral ENaC-type channels is unknown. Possibly, the channels are normally closed or of very low open probability in the resting state.

Published
1998

39. [Untitled]

Author

B. Lindemann, O. Kretz, and R. Bock

Subjects
chemistry.chemical_classification, Taste, ATP synthase, biology, Cell Biology, Nitric oxide, Cell biology, Nitric oxide synthase, chemistry.chemical_compound, Paracrine signalling, Enzyme, chemistry, Biochemistry, biology.protein, Immunohistochemistry, Anatomy, Lingual papilla
Abstract

Nitric oxide (NO) is generated by some types of cells as a membrane-permeant, short-acting paracrine signal. Its effects include activation of ion channels as well as formation of cGMP in the NO-generating and/or neighbouring cells. We have explored the possible involvement of NO in taste transduction by searching for NO synthase with histochemical and immunohistochemical methods. In taste buds of the rat vallate and foliate papilla, we found NADPH-diaphorase activity under stringent conditions that suppress the reactions of non-NO synthase enzymes. Furthermore, an antibody against neuronal NO synthase (NOS-I) labelled the basal and apical parts of taste cells, while an antibody against endothelial NO synthase (NOS-III) labelled taste buds and lingual epithelium more uniformly. The inducible macrophage enzyme NOS-II did not show immunoreactivity in taste buds. The results provide a first suggestion that NO may play a role in taste transduction. © 1998 Chapman & Hall

Published
1998

40. Sodium taste

Author

B, Lindemann

Subjects
Nephrology, Sodium, Internal Medicine, Animals, Humans, Biological Transport, Intestinal Mucosa, Kidney
Abstract

The regulation of sodium metabolism is achieved by the adaptive sodium-saving capacities in epithelia and by hormones acting within the brain to modulate salt appetite. Taste, especially in rodents, has a sodium-specific component that provides a guiding function for salt intake. The taste responsiveness is not invariable, however, and may be modified in the case of sodium need. This review discusses emerging functional aspects of the peripheral and central branch of the salt sensory pathway.

Published
1997

41. ['With all suitable means'. Off-label-use and public statutory employers' liability insurance]

Author

C, Skudlik, B, Lindemann, M, Woltjen, S, Brandenburg, and S M, John

Subjects
Health Benefit Plans, Employee, National Health Programs, Germany, Humans, Dermatology, Off-Label Use, Insurance, Liability, Skin Diseases
Abstract

In Germany, responsibility for treatment of occupational diseases lies with the public statutory employers' liability insurances (SELI). According to their legal obligation SELI have to ascertain cure--wherever possible--"with all suitable means". Thus, dermatologists treating patients with occupational dermatoses are required to deliver the best possible therapy, which, according to the current scientific knowledge, may in some cases be off-label. For example, in occupational contact dermatitis a number of scientifically promising topical and systemic drugs are not yet licensed for this indication. Off-label prescribing is not prohibited and there are no laws limiting physician flexibility in such prescribing. SELI also allows the use of off-label drugs. The goals of optimal treatment or effective prevention of occupational disease determine the measures which can be employed. Off-label use is approved for occupational skin diseases when the medication is required for cure or prevention and its use meets generally accepted medical standards. In these cases, SELI will cover off-label drug prescriptions. However, detailed patient counseling and informed consent are mandatory.

Published
2013

42. Observation of multiple hard photon final states at GeV at LEP

Author

M. Campanelli, D. Antreasyan, Sc Yeh, L. Romero, Marcella Diemoz, P. G. Rancoita, Wt Lin, B. Schoeneich, P. Kapinos, Samuel C.C. Ting, H. Kuijten, A. Lebedev, Dong-Chul Son, T. Kramer, B. N. Jin, H. Nowak, P. Duinker, I. Korolko, Simonetta Gentile, P. Rosselet, Z. P. Zhang, R. Barillère, A. C. Weber, Ren-Yuan Zhu, Luciano Barone, J. J. Blaising, Aaron Dominguez, M. N. Kienzle-Focacci, A. Klimentov, S. Mele, Kajari Mazumdar, Stefano Giagu, C. Lapoint, Felicitas Pauss, M. Bourquin, A. Straessner, Luca Lista, D. Fernandez, Juven Wang, Sabine Riemann, C-Q. Li, T. van Rhee, P. Extermann, Christoph Schäfer, B. Z. Yang, H. Hofer, K. L. Tung, H. Janssen, Kenneth Francis Read, Alessandra Doria, S. Müller, E. Valente, K. Strauch, Mariagrazia Alviggi, W. Wallraff, W. G. Ma, M. Basile, J. Gerald, Dai-Sik Kim, V. K. Gupta, R. Faccini, G. Mirabelli, D. McNally, X. L. Wang, G. G.G. Massaro, S. Banerjee, A. Gurtu, V. Commichau, M. Lebeau, A. Tsaregorodtsev, K. Y. Lee, I. Vetlitsky, M. Pauluzzi, Xd Cai, K. Hangarter, Joachim Mnich, G. Viertel, Y. J. Pei, W. van Rossum, G.M. Chan, S. C. Blyth, Adrian Biland, Z. A. Liu, A. Vorvolakos, X. Y. Yao, Hans J. Vogel, S. Morganti, J. K. Kim, D. Luckey, J. G. Xu, Reinhard W. Schulte, Marco Meschini, Tariq Aziz, J. Schwenke, G. M. Bilei, S. Ro, F. DeNotaristefani, M. Lenti, K. Lübelsmeyer, S. Costantini, R. Leiste, Christoph Paus, B. L. Betev, D. Ren, A. Robohm, Gianpaolo Carlino, B. Hartmann, A. Hasan, Y. Kamyshkov, Gobinda Majumder, A. Engler, J. Shukla, P. Marchesini, N. Gheordanescu, V. Brigljevic, B. De La Cruz, G. Hu, Giovanni Ambrosi, N. Scholz, J. M. You, A. Macchiolo, Manas Maity, S. Petrak, Lamberto Luminari, A. M. Cartacci, R. Raghavan, A. C. König, Andre Sopczak, Joel Goldstein, A. Favara, Z. Z. Xu, V. Pojidaev, M. Capell, J.V. Allaby, Vincenzo Innocente, Yu. Galaktionov, S. P. Ahlen, S. Patricelli, A. Boucham, W. Kittel, M. Caria, H. S. Fesefeldt, E. Pistolesi, A. P. Colijn, D.W. Schmitz, G. Pascale, N. Shivarov, Claudio Luci, Crisostomo Sciacca, J. A. Rubio, E. Nagy, F. Cesaroni, Marco Pieri, S. R. Hou, M. Wadhwa, D. J. Schotanus, M. Chamizo, J. Alcaraz, B. Monteleoni, F. Sticozzi, P. Berges, Steve Nahn, Roberto Castello, F. Muheim, Igor Vorobiev, M. Sassowsky, A. J.W. van Mil, J. Rodin, C. Dionisi, P. Levtchenko, S.X. Wu, Robert Clare, Alain Hervé, F. DiLodovico, P. Bartalini, Thomas Hebbeker, Paul Lecoq, R. W. Kraemer, A. Nippe, R. T. Van de Walle, Panos A Razis, A. Koulbardis, Konrad Deiters, R. C. Ball, J. S. Lee, Pierre Lecomte, Christopher George Tully, Alexander Malinin, L. Fredj, S. Easo, J. P. Ernenwein, Kati Lassila-Perini, M. Fabre, P. Lebrun, M. Napolitano, P. LeCoultre, Emilio Leonardi, R. Bock, D. Sciarrino, M. T. Choi, Francesca Nessi-Tedaldi, Alberto Aloisio, O. Toker, A. Ricker, Speranza Falciano, F. C. Erné, V. Plyaskin, Werner Lustermann, Behcet Alpat, L. J. Gutay, Howard A. Stone, A. Mihul, G. Alemanni, Y. Karyotakis, P. Schmitz, U. Becker, H. Anderhub, W. J. Burger, M. Vivargent, A. Bay, M. Acciarri, Pierluigi Paolucci, M. Möller, J. Berdugo, V. Koutsenko, D. Duchesneau, H. S. Chen, L. Servoli, L. Baksay, F. Cotorobai, Wolfgang Lohmann, B. Bertucci, S. C. Kim, E. J. Sanchez, H. ElMamouni, A. Buijs, C. Zaccardelli, M. T. Dova, A. Köngeter, F. Tonisch, I. Duran, Roberto Battiston, G. Schwering, W. W. Kinnison, J. D. Burger, T. Siedenburg, G. F. Susinno, H. O. Cohn, H. Vogt, G. Rahal-Callot, U. Uwer, A. Chen, D. van Dierendonck, G. Forconi, J. Salicio, R. Mount, X. W. Tang, Nicola Cavallo, A. Buytenhuijs, An. Zalite, Nicanor Colino, P. A. Piroué, B. Zhou, G. Landi, H. K. Park, Egidio Longo, H. Tuchscherer, Simone Paoletti, Suchandra Dutta, J. Kirby, F. J. Eppling, L. W. Jones, Gerjan Bobbink, B. Borgia, P. H. Fisher, J. Ulbricht, P. de Jong, S. M. Ting, Maurizio Biasini, Carlo Civinini, Raffaello D'Alessandro, Michael Dittmar, Marta Felcini, G. Raven, Francesca Cavallari, S. Roth, I. Dorne, U. K. Chaturvedi, A. Pevsner, K. Freudenreich, Manjit Kaur, G. Chiefari, C. Furetta, J. C. Pinto, K. Schultze, G. Castellini, Francesco Becattini, S. Shevchenko, M. M. Ilyas, S. S. Gau, Leonardo Merola, Z. F. Gong, P. Zemp, J. P. Martin, R. de Asmundis, Y. S. Lu, J. D. Swain, A. Kasser, D. Peach, A. Chan, M.E. Sarakinos, L. Tauscher, G. Y. Zhu, E. Shumilov, F. Behner, Andrea Baschirotto, Roger Moore, M. Aguilar-Benitez, T. Azemoon, I. Clare, Jozsef Toth, Herwig Schopper, D. Pandoulas, M. Rescigno, H. Suter, Y. F. Wang, V. Shoutko, J. C. Sens, B. C. Riemers, J. H. Field, C. Y. Chien, G.C. Romeo, A. Adam, B. Stoyanov, S. Schmidt-Kaerst, A. Böhm, R. Völkert, H. Postema, T. Paul, Marcos Cerrada, H. F. Chen, J. Busenitz, Y. Mi, Georgi Sultanov, P. De Ladron Guevara, Fl Linde, T. S. Dai, Peter Denes, R. A. Khan, M. Tonutti, Y. Zhou, J. G. Branson, S. Wynhoff, B. Lindemann, Paolo Bagnaia, G. Gratta, W. Lu, Davide Piccolo, Dimitri Bourilkov, P. Spillantini, X. Chereau, Federico Cindolo, A. Kunin, V. P. Andreev, S. Mangla, M. Chemarin, L. Z. Sun, H. DeBoeck, S. N. Ganguli, D. P. Stickland, Luisa Cifarelli, S. Reucroft, S. C. Tonwar, E. Fiandrini, Luca Malgeri, W. C. van Hoek, Frank Filthaut, Hafeez R Hoorani, G. M. Chen, A. Kirby, A. Degré, Thomas Ferguson, M. Schneegans, Harvey B Newman, Bryan R. Smith, K. Sudhakar, M. Rattaggi, M. von der Mey, J. B. Ye, W. J. Metzger, D. Kirby, Z. M. Wang, A. Gougas, C. Maña, S. Röhner, B. P. Roe, F. Wittgenstein, L. Ludovici, E. Drago, C. Cecchi, S. Goldfarb, I. C. Brock, Subir Sarkar, A. Bujak, M. Pohl, R. Ostonen, A. Marin, S. Pensotti, Valery Schegelsky, Antonino Zichichi, H. Rykaczewski, Giovanni Organtini, J.M. LeGoff, S. Rosier-Lees, Attilio Santocchia, Jean Fay, Y. G. Kim, Nicolas Produit, Y. H. Chang, George Alverson, J. S. Kapustinsky, F. Ferroni, Y. Zeng, A. Arefiev, Yu. Efremenko, R. R. McNeil, T. Angelescu, E. Lieb, E. Brambilla, J. Casaus, K. Riles, F. Marzano, G. Coignet, W. Krenz, C. G. Yang, D. DiBitonto, M. Steuer, F. J. Rodriguez, K. Banicz, An.A. Vorobyov, O. Adriani, Lucas Taylor, D. Perret-Gallix, G. Passaleva, M. W. Gruenewald, and I. Josa-Mutuberria

Subjects
Physics, Nuclear and High Energy Physics, Range (particle radiation), Particle physics, Luminosity (scattering theory), Photon, 010308 nuclear & particles physics, Electron–positron annihilation, Scalar (mathematics), 01 natural sciences, Nuclear physics, Angular distribution, 0103 physical sciences, High Energy Physics::Experiment, 010306 general physics, Event (particle physics)
Abstract

We have studied the process e+e− → nγ (n ≥ 2) at an average center-of-mass energy of 133 GeV using the L3 detector at LEP. For an integrated luminosity of 4.95 pb−1 we find one γγγγ(γ) final state with only hard photons. The rates of both γγγ and γγ events are consistent with QED expectations. The cross section of the reaction e+e− → γγ(γ) in the polar range 16° < θγ < 164° is measured to be 22.6 ± 2.2 pb. Decays into photons of narrow scalar resonances with masses between 90 and 130 GeV are not observed. The observation of the event with four energetic photons is consistent with QED although the kinematic configuration of the photons is atypical.

Published
1996

43. Taste reception

Author

B, Lindemann

Subjects
Physiology, Taste, Physiology (medical), Animals, General Medicine, Taste Buds, Molecular Biology, Ion Channels, Rats
Abstract

Recent research on cellular mechanisms of peripheral taste has defined transduction pathways involving membrane receptors, G proteins, second messengers, and ion channels. Receptors for organic tastants received much attention, because they provide the specificity of a response. Their future cloning will constitute a major advance. Taste transduction typically utilizes two or more pathways in parallel. For instance, sweet-sensitive taste cells of the rat appear to respond to sucrose with activation of adenylyl cyclase, followed by adenosine 3',5'-cyclic monophosphate (cAMP)-dependent membrane events and Ca2+ uptake. The same cells respond differently to some artificial sweeteners, i.e., with activation of phospholipase C (PLC) followed by inositol 1,4,5-trisphosphate (IP3)-dependent Ca2+ release from intracellular stores. Some bitter tastants block K+ channels or initiate the cascade receptor G1 protein, PLC, IP3, and Ca2+ release or the cascade receptor alpha-gustducin, phosphodiesterase (PDE), cAMP decrease, and opening of cAMP-blocked channels. Membrane-permeant bitter tastants may elicit a cellular response by interacting with G protein, PLC, or PDE of the above cascades. Salt taste is initiated by current flowing into the taste cell through cation channels located in the apical membrane, even though basolateral channels may also contribute (following salt diffusion through paracellular pathways). In rodents, the Na+-specific component of salt taste is typically mediated by apical amiloride-sensitive Na+ channels, but less specific and not amiloride-sensitive taste components exist in addition. Sour taste may in part be mediated by amiloride-sensitive Na+ channels conducting protons, but other mechanisms certainly contribute. Thus the transduction of taste cells generally comprises parallel pathways. Furthermore, the transduction pathways vary with the location of taste buds on the tongue and, of course, across species of animals. To identify these pathways, to understand how they are controlled and why they evolved to this complexity are major goals of present research.

Published
1996

44. Search for unstable sequential neutral and charged heavy leptons in e+e− annihilation at and 136 GeV

Author

M Acciarri, A Adam, O Adriani, M Aguilar-Benitez, S Ahlen, B Alpat, J Alcaraz, G Alemanni, J Allaby, A Aloisio, G Alverson, M.G Alviggi, G Ambrosi, H Anderhub, V.P Andreev, T Angelescu, D Antreasyan, A Arefiev, T Azemoon, T Aziz, P Bagnaia, L Baksay, R.C Ball, S Banerjee, K Banicz, R Barillère, L Barone, P Bartalini, A Baschirotto, M Basile, R Battiston, A Bay, F Becattini, U Becker, F Behner, J Berdugo, P Berges, B Bertucci, B.L Betev, M Biasini, A Biland, G.M Bilei, J.J Blaising, S.C Blyth, G.J Bobbink, R Bock, A Böhm, B Borgia, A Boucham, D Bourilkov, M Bourquin, E Brambilla, J.G Branson, V Brigljevic, I.C Brock, A Buijs, A Bujak, J.D Burger, W.J Burger, J Busenitz, A Buytenhuijs, X.D Cai, M Campanelli, M Capell, G Cara Romeo, M Caria, G Carlino, A.M Cartacci, J Casaus, G Castellini, R Castello, F Cavallari, N Cavallo, C Cecchi, M Cerrada, F Cesaroni, M Chamizo, A Chan, Y.H Chang, U.K Chaturvedi, M Chemarin, A Chen, G Chen, G.M Chen, H.F Chen, H.S Chen, X Chereau, G Chiefari, C.Y Chien, M.T Choi, L Cifarelli, F Cindolo, C Civinini, I Clare, R Clare, H.O Cohn, G Coignet, A.P Colijn, N Colino, V Commichau, S Costantini, F Cotorobai, B de la Cruz, T.S Dai, R D'Alessandro, R de Asmundis, H De Boeck, A Degré, K Deiters, P Denes, F DeNotaristefani, D DiBitonto, M Diemoz, D van Dierendonck, F Di Lodovico, C Dionisi, M Dittmar, A Dominguez, A Doria, I Dorne, M.T Dova, E Drago, D Duchesneau, P Duinker, I Duran, S Dutta, S Easo, Yu Efremenko, H El Mamouni, A Engler, F.J Eppling, F.C Erné, J.P Ernenwein, P Extermann, M Fabre, R Faccini, S Falciano, A Favara, J Fay, M Felcini, C Furetta, T Ferguson, D Fernandez, F Ferroni, H Fesefeldt, E Fiandrini, J.H Field, F Filthaut, P.H Fisher, G Forconi, L Fredj, K Freudenreich, Yu Galaktionov, S.N Ganguli, S.S Gau, S Gentile, J Gerald, N Gheordanescu, S Giagu, S Goldfarb, J Goldstein, Z.F Gong, A Gougas, G Gratta, M.W Gruenewald, V.K Gupta, A Gurtu, L.J Gutay, K Hangarter, B Hartmann, A Hasan, T Hebbeker, A Hervé, W.C van Hoek, H Hofer, H Hoorani, S.R Hou, G Hu, M.M Ilyas, V Innocente, H Janssen, B.N Jin, L.W Jones, P de Jong, I Josa-Mutuberria, A Kasser, R.A Khan, Yu Kamyshkov, P Kapinos, J.S Kapustinsky, Y Karyotakis, M Kaur, M.N Kienzle-Focacci, D Kim, J.K Kim, S.C Kim, Y.G Kim, W.W Kinnison, A Kirkby, D Kirkby, J Kirkby, W Kittel, A Klimentov, A.C König, A Köngeter, I Korolko, V Koutsenko, A Koulbardis, R.W Kraemer, T Kramer, W Krenz, H Kuijten, A Kunin, P Ladron de Guevara, G Landi, C Lapoint, K Lassila-Perini, M Lebeau, A Lebedev, P Lebrun, P Lecomte, P Lecoq, P Le Coultre, J.S Lee, K.Y Lee, J.M Le Goff, R Leiste, M Lenti, E Leonardi, P Levtchenko, C Li, E Lieb, W.T Lin, F.L Linde, B Lindemann, L Lista, Z.A Liu, W Lohmann, E Longo, W Lu, Y.S Lu, K Lübelsmeyer, C Luci, D Luckey, L Ludovici, L Luminari, W Lustermann, W.G Ma, S Macchiolo, M Maity, G Majumder, L Malgeri, A Malinin, C Maña, S Mangla, P Marchesini, A Marin, J.P Martin, F Marzano, G.G.G Massaro, K Mazumdar, D McNally, R.R McNeil, S Mele, L Merola, M Meschini, W.J Metzger, M von der Mey, Y Mi, A Mihul, A.J.W van Mil, G Mirabelli, J Mnich, M Möller, B Monteleoni, R Moore, S Morganti, R Mount, S Müller, F Muheim, E Nagy, S Nahn, M Napolitano, F Nessi-Tedaldi, H Newman, A Nippe, H Nowak, G Organtini, R Ostonen, D Pandoulas, S Paoletti, P Paolucci, H.K Park, G Pascale, G Passaleva, S Patricelli, T Paul, M Pauluzzi, C Paus, F Pauss, D Peach, Y.J Pei, S Pensotti, D Perret-Gallix, S Petrak, A Pevsner, D Piccolo, M Pieri, J.C Pinto, P.A Piroué, E Pistolesi, V Plyaskin, M Pohl, V Pojidaev, H Postema, N Produit, R Raghavan, G Rahal-Callot, P.G Rancoita, M Rattaggi, G Raven, P Razis, K Read, D Ren, M Rescigno, S Reucroft, T van Rhee, A Ricker, S Riemann, B.C Riemers, K Riles, S Ro, A Robohm, J Rodin, F.J Rodriguez, B.P Roe, S Röhner, L Romero, S Rosier-Lees, Ph Rosselet, W van Rossum, S Roth, J.A Rubio, H Rykaczewski, J Salicio, E Sanchez, A Santocchia, M.E Sarakinos, S Sarkar, M Sassowsky, C Schäfer, V Schegelsky, S Schmidt-Kaerst, D Schmitz, P Schmitz, M Schneegans, B Schoeneich, N Scholz, H Schopper, D.J Schotanus, R Schulte, K Schultze, J Schwenke, G Schwering, C Sciacca, D Sciarrino, J.C Sens, L Servoli, S Shevchenko, N Shivarov, V Shoutko, J Shukla, E Shumilov, T Siedenburg, D Son, A Sopczak, B Smith, P Spillantini, M Steuer, D.P Stickland, F Sticozzi, H Stone, B Stoyanov, A Straessner, K Strauch, K Sudhakar, G Sultanov, L.Z Sun, G.F Susinno, H Suter, J.D Swain, X.W Tang, L Tauscher, L Taylor, Samuel C.C Ting, S.M Ting, O Toker, F Tonisch, M Tonutti, S.C Tonwar, J Tóth, A Tsaregorodtsev, C Tully, H Tuchscherer, K.L Tung, J Ulbricht, U Uwer, E Valente, R.T Van de Walle, I Vetlitsky, G Viertel, M Vivargent, R Völkert, H Vogel, H Vogt, I Vorobiev, A.A Vorobyov, An.A Vorobyov, A Vorvolakos, M Wadhwa, W Wallraff, J.C Wang, X.L Wang, Y.F Wang, Z.M Wang, A Weber, F Wittgenstein, S.X Wu, S Wynhoff, J Xu, Z.Z Xu, B.Z Yang, C.G Yang, X.Y Yao, J.B Ye, S.C Yeh, J.M You, C Zaccardelli, An Zalite, P Zemp, Y Zeng, Z Zhang, Z.P Zhang, B Zhou, Y Zhou, G.Y Zhu, R.Y Zhu, and A Zichichi

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Range (particle radiation), Annihilation, Muon, Physics::Instrumentation and Detectors, 010308 nuclear & particles physics, Astrophysics::High Energy Astrophysical Phenomena, Electron–positron annihilation, High Energy Physics::Phenomenology, Electron, 01 natural sciences, 7. Clean energy, Nuclear physics, MAJORANA, 0103 physical sciences, High Energy Physics::Experiment, Neutrino, Nuclear Experiment, 010306 general physics, Lepton
Abstract

A search for unstable sequential neutral and charged heavy leptons has been made at center-of-mass energies 130 and 136 GeV with the L3 detector at LEP. The neutral leptons are assumed to decay via mixing to electrons and muons. No evidence for their existence was found. We exclude unstable Dirac neutrinos for masses below 59.3 (57.9) GeV and unstable Majorana neutrinos below 48.6 (47.2) GeV if the neutrino couples to the electron(muon) family. We exclude unstable charged heavy leptons for masses below 61 GeV for a wide range of the associated neutral lepton mass.

Published
1996

45. Search for supersymmetric particles at at LEP

Author

M Acciarri, A Adam, O Adriani, M Aguilar-Benitez, S Ahlen, B Alpat, J Alcaraz, G Alemanni, J Allaby, A Aloisio, G Alverson, M.G Alviggi, G Ambrosi, H Anderhub, V.P Andreev, T Angelescu, D Antreasyan, A Arefiev, T Azemoon, T Aziz, P Bagnaia, L Baksay, R.C Ball, S Banerjee, K Banicz, R Barillère, L Barone, P Bartalini, A Baschirotto, M Basile, R Battiston, A Bay, F Becattini, U Becker, F Behner, J Berdugo, P Berges, B Bertucci, B.L Betev, M Biasini, A Biland, G.M Bilei, J.J Blaising, S.C Blyth, G.J Bobbink, R Bock, A Böhm, B Borgia, A Boucham, D Bourilkov, M Bourquin, E Brambilla, J.G Branson, V Brigljevic, I.C Brock, A Buijs, A Bujak, J.D Burger, W.J Burger, J Busenitz, A Buytenhuijs, X.D Cai, M Campanelli, M Capell, G.Cara Romeo, M Caria, G Carlino, A.M Cartacci, J Casaus, G Castellini, R Castello, F Cavallari, N Cavallo, C Cecchi, M Cerrada, F Cesaroni, M Chamizo, A Chan, Y.H Chang, U.K Chaturvedi, M Chemarin, A Chen, C Chen, G Chen, G.M Chen, H.F Chen, H.S Chen, X Chereau, G Chiefari, C.Y Chien, M.T Choi, L Cifarelli, F Cindolo, C Civinini, I Clare, R Clare, H.O Cohn, G Coignet, A.P Colijn, N Colino, V Commichau, S Costantini, F Cotorobai, B de la Cruz, T.S Dai, R D'Alessandro, R de Asmundis, H De Boeck, A Degré, K Deiters, P Denes, F DeNotaristefani, D DiBitonto, M Diemoz, D van Dierendonck, F Di Lodovico, C Dionisi, M Dittmar, A Dominguez, A Doria, I Dorne, M.T Dova, E Drago, D Duchesneau, P Duinker, I Duran, S Dutta, S Easo, Yu Efremenko, H El Mamouni, A Engler, F.J Eppling, F.C Erné, J.P Ernenwein, P Extermann, M Fabre, R Faccini, S Falciano, A Favara, J Fay, M Felcini, T Ferguson, D Fernandez, F Ferroni, H Fesefeldt, E Fiandrini, J.H Field, F Filthaut, P.H Fisher, G Forconi, L Fredj, K Freudenreich, Yu Galaktionov, S.N Ganguli, S.S Gau, S Gentile, J Gerald, N Gheordanescu, S Giagu, S Goldfarb, J Goldstein, Z.F Gong, A Gougas, G Gratta, M.W Gruenewald, V.K Gupta, A Gurtu, L.J Gutay, K Hangarter, B Hartmann, A Hasan, J.T He, T Hebbeker, A Hervé, W.C van Hoek, H Hofer, H Hoorani, S.R Hou, G Hu, M.M Ilyas, V Innocente, H Janssen, B.N Jin, L.W Jones, P de Jong, I Josa-Mutuberria, A Kasser, R.A Khan, Yu Kamyshkov, P Kapinos, J.S Kapustinsky, Y Karyotakis, M Kaur, M.N Kienzle-Focacci, D Kim, J.K Kim, S.C Kim, Y.G Kim, W.W Kinnison, A Kirkby, D Kirkby, J Kirkby, W Kittel, A Klimentov, A.C König, A Köngeter, I Korolko, V Koutsenko, A Koulbardis, R.W Kraemer, T Kramer, W Krenz, H Kuijten, A Kunin, P.Ladron de Guevara, G Landi, C Lapoint, K Lassila-Perini, M Lebeau, A Lebedev, P Lebrun, P Lecomte, P Lecoq, P Le Coultre, J.S Lee, K.Y Lee, J.M Le Goff, R Leiste, M Lenti, E Leonardi, P Levtchenko, C Li, E Lieb, W.T Lin, F.L Linde, B Lindemann, L Lista, Z.A Liu, W Lohmann, E Longo, W Lu, Y.S Lu, K Lübelsmeyer, C Luci, D Luckey, L Ludovici, L Luminari, W Lustermann, W.G Ma, A Macchiolo, M Maity, G Majumder, L Malgeri, A Malinin, C Maña, S Mangla, P Marchesini, A Marin, J.P Martin, F Marzano, G.G.G Massaro, K Mazumdar, D McNally, R.R McNeil, S Mele, L Merola, M Meschini, W.J Metzger, M von der Mey, Y Mi, A Mihul, A.J.W van Mil, G Mirabelli, J Mnich, M Möller, B Monteleoni, R Moore, S Morganti, R Mount, S Müller, F Muheim, E Nagy, S Nahn, M Napolitano, F Nessi-Tedaldi, H Newman, A Nippe, H Nowak, G Organtini, R Ostonen, D Pandoulas, S Paoletti, P Paolucci, H.K Park, G Pascale, G Passaleva, S Patricelli, T Paul, M Pauluzzi, C Paus, F Pauss, D Peach, Y.J Pei, S Pensotti, D Perret-Gallix, S Petrak, A Pevsner, D Piccolo, M Pieri, J.C Pinto, P.A Piroué, E Pistolesi, V Plyaskin, M Pohl, V Pojidaev, H Postema, N Produit, R Raghavan, G Rahal-Callot, P.G Rancoita, M Rattaggi, G Raven, P Razis, K Read, M Redaelli, D Ren, M Rescigno, S Reucroft, A Ricker, S Riemann, B.C Riemers, K Riles, S Ro, A Robohm, J Rodin, F.J Rodriguez, B.P Roe, S Röhner, L Romero, S Rosier-Lees, Ph Rosselet, W van Rossum, S Roth, J.A Rubio, H Rykaczewski, J Salicio, E Sanchez, A Santocchia, M.E Sarakinos, S Sarkar, M Sassowsky, C Schäfer, V Schegelsky, S Schmidt-Kaerst, D Schmitz, P Schmitz, M Schneegans, B Schoeneich, N Scholz, H Schopper, D.J Schotanus, R Schulte, K Schultze, J Schwenke, G Schwering, C Sciacca, D Sciarrino, J.C Sens, L Servoli, S Shevchenko, N Shivarov, V Shoutko, J Shukla, E Shumilov, T Siedenburg, D Son, A Sopczak, B Smith, P Spillantini, M Steuer, D.P Stickland, F Sticozzi, H Stone, B Stoyanov, A Straessner, K Strauch, K Sudhakar, G Sultanov, L.Z Sun, G.F Susinno, H Suter, J.D Swain, X.W Tang, L Tauscher, L Taylor, Samuel C.C Ting, S.M Ting, O Toker, F Tonisch, M Tonutti, S.C Tonwar, J Tóth, A Tsaregorodtsev, C Tully, H Tuchscherer, K.L Tung, J Ulbricht, U Uwer, E Valente, R.T Van de Walle, I Vetlitsky, G Viertel, M Vivargent, R Völkert, H Vogel, H Vogt, I Vorobiev, A.A Vorobyov, An.A Vorobyov, A Vorvolakos, M Wadhwa, W Wallraff, J.C Wang, X.L Wang, Y.F Wang, Z.M Wang, A Weber, F Wittgenstein, S.X Wu, S Wynhoff, J Xu, Z.Z Xu, B.Z Yang, C.G Yang, X.Y Yao, J.B Ye, S.C Yeh, J.M You, C Zaccardelli, An Zalite, P Zemp, J.Y Zeng, Y Zeng, Z Zhang, Z.P Zhang, B Zhou, G.J Zhou, Y Zhou, G.Y Zhu, R.Y Zhu, and A Zichichi

Subjects
Quark, Physics, Nuclear and High Energy Physics, Particle physics, Luminosity (scattering theory), 010308 nuclear & particles physics, Electron–positron annihilation, High Energy Physics::Phenomenology, Supersymmetry, 01 natural sciences, 7. Clean energy, law.invention, Nuclear physics, Chargino, law, 0103 physical sciences, Neutralino, High Energy Physics::Experiment, 010306 general physics, Collider
Abstract

A search for supersymmetric particles (charginos, neutralinos, sleptons and stop quarks) has been performed with data collected by the L3 detector during the November 1995 run of the LEP collider at centre of mass energies between 130 and 140 GeV with a total integrated luminosity of 5.1 pb−1. We observe no signal for supersymmetric particles and we set improved exclusion limits on their production cross sections and masses.

Published
1996

46. Measurement of muon-pair production at at LEP

Author

M. Acciarri, A. Adam, O. Adriani, M. Aguilar-Benitez, S. Ahlen, B. Alpat, J. Alcaraz, G. Alemanni, J. Allaby, A. Aloisio, G. Alverson, M.G. Alviggi, G. Ambrosi, H. Anderhub, V.P. Andreev, T. Angelescu, D. Antreasyan, A. Arefiev, T. Azemoon, T. Aziz, P. Bagnaia, L. Baksay, R.C. Ball, S. Banerjee, K. Banicz, R. Barillère, L. Barone, P. Bartalini, A. Baschirotto, M. Basile, R. Battiston, A. Bay, F. Becattini, U. Becker, F. Behner, J. Berdugo, P. Berges, B. Bertucci, B.L. Betev, M. Biasini, A. Biland, G.M. Bilei, J.J. Blaising, S.C. Blyth, G.J. Bobbink, R. Bock, A. Böhm, B. Borgia, A. Boucham, D. Bourilkov, M. Bourquin, D. Boutigny, E. Brambilla, J.G. Branson, V. Brigljevic, I.C. Brock, A. Buijs, A. Bujak, J.D. Burger, W.J. Burger, J. Busenitz, A. Buytenhuijs, X.D. Cai, M. Campanelli, M. Capell, G. Cara Romeo, M. Caria, G. Carlino, A.M. Cartacci, J. Casaus, G. Castellini, R. Castello, F. Cavallari, N. Cavallo, C. Cecchi, M. Cerrada, F. Cesaroni, M. Chamizo, A. Chan, Y.H. Chang, U.K. Chaturvedi, M. Chemarin, A. Chen, C. Chen, G. Chen, G.M. Chen, H.F. Chen, H.S. Chen, M. Chen, G. Chiefari, C.Y. Chien, M.T. Choi, L. Cifarelli, F. Cindolo, C. Civinini, I. Clare, R. Clare, H.O. Cohn, G. Coignet, A.P. Colijn, N. Colino, V. Commichau, S. Costantini, F. Cotorobai, B. de la Cruz, T.S. Dai, R. D'Alessandro, R. de Asmundis, H. De Boeck, A. Degré, K. Deiters, P. Denes, F. DeNotaristefani, D. DiBitonto, M. Diemoz, D. van Dierendonck, F. Di Lodovico, C. Dionisi, M. Dittmar, A. Dominguez, A. Doria, I. Dorne, M.T. Dova, E. Drago, D. Duchesneau, P. Duinker, I. Duran, S. Dutta, S. Easo, Yu. Efremenko, H. El Mamouni, A. Engler, F.J. Eppling, F.C. Erné, J.P. Ernenwein, P. Extermann, M. Fabre, R. Faccini, S. Falciano, A. Favara, J. Fay, M. Felcini, T. Ferguson, D. Fernandez, F. Ferroni, H. Fesefeldt, E. Fiandrini, J.H. Field, F. Filthaut, P.H. Fisher, G. Forconi, L. Fredj, K. Freudenreich, Yu. Galaktionov, S.N. Ganguli, S.S. Gau, S. Gentile, J. Gerald, N. Gheordanescu, S. Giagu, S. Goldfarb, J. Goldstein, Z.F. Gong, A. Gougas, G. Gratta, M.W. Gruenewald, V.K. Gupta, A. Gurtu, L.J. Gutay, K. Hangarter, B. Hartmann, A. Hasan, J.T. He, T. Hebbeker, A. Hervé, W.C. van Hoek, H. Hofer, H. Hoorani, S.R. Hou, G. Hu, M.M. Ilyas, V. Innocente, H. Janssen, B.N. Jin, L.W. Jones, P. de Jong, I. Josa-Mutuberria, A. Kasser, R.A. Khan, Yu. Kamyshkov, P. Kapinos, J.S. Kapustinsky, Y. Karyotakis, M. Kaur, M.N. Kienzle-Focacci, D. Kim, J.K. Kim, S.C. Kim, Y.G. Kim, W.W. Kinnison, A. Kirkby, D. Kirkby, J. Kirkby, W. Kittel, A. Klimentov, A.C. König, A. Köngeter, I. Korolko, V. Koutsenko, A. Koulbardis, R.W. Kraemer, T. Kramer, W. Krenz, H. Kuijten, A. Kunin, P. Ladron de Guevara, G. Landi, C. Lapoint, K. Lassila-Perini, M. Lebeau, A. Lebedev, P. Lebrun, P. Lecomte, P. Lecoq, P. Le Coultre, J.S. Lee, K.Y. Lee, C. Leggett, J.M. Le Goff, R. Leiste, M. Lenti, E. Leonardi, P. Levtchenko, C. Li, E. Lieb, W.T. Lin, F.L. Linde, B. Lindemann, L. Lista, Z.A. Liu, W. Lohmann, E. Longo, W. Lu, Y.S. Lu, K. Lübelsmeyer, C. Luci, D. Luckey, L. Ludovici, L. Luminari, W. Lustermann, W.G. Ma, A. Macchiolo, M. Maity, G. Majumder, L. Malgeri, A. Malinin, C. Maña, S. Mangla, P. Marchesini, A. Marin, J.P. Martin, F. Marzano, G.G.G. Massaro, K. Mazumdar, D. McNally, S. Mele, L. Merola, M. Meschini, W.J. Metzger, M. von der Mey, Y. Mi, A. Mihul, A.J.W. van Mil, G. Mirabelli, J. Mnich, M. Möller, B. Monteleoni, R. Moore, S. Morganti, R. Mount, S. Müller, F. Muheim, E. Nagy, S. Nahn, M. Napolitano, F. Nessi-Tedaldi, H. Newman, A. Nippe, H. Nowak, G. Organtini, R. Ostonen, D. Pandoulas, S. Paoletti, P. Paolucci, H.K. Park, G. Pascale, G. Passaleva, S. Patricelli, T. Paul, M. Pauluzzi, C. Paus, F. Pauss, D. Peach, Y.J. Pei, S. Pensotti, D. Perret-Gallix, S. Petrak, A. Pevsner, D. Piccolo, M. Pieri, J.C. Pinto, P.A. Piroué, E. Pistolesi, V. Plyaskin, M. Pohl, V. Pojidaev, H. Postema, N. Produit, R. Raghavan, G. Rahal-Callot, P.G. Rancoita, M. Rattaggi, G. Raven, P. Razis, K. Read, M. Redaelli, D. Ren, M. Rescigno, S. Reucroft, A. Ricker, S. Riemann, B.C. Riemers, K. Riles, O. Rind, S. Ro, A. Robohm, J. Rodin, F.J. Rodriguez, B.P. Roe, S. Röhner, L. Romero, S. Rosier-Lees, Ph. Rosselet, W. van Rossum, S. Roth, J.A. Rubio, H. Rykaczewski, J. Salicio, E. Sanchez, A. Santocchia, M.E. Sarakinos, S. Sarkar, M. Sassowsky, G. Sauvage, C. Schäfer, V. Schegelsky, S. Schmidt-Kaerst, D. Schmitz, P. Schmitz, M. Schneegans, B. Schoeneich, N. Scholz, H. Schopper, D.J. Schotanus, R. Schulte, K. Schultze, J. Schwenke, G. Schwering, C. Sciacca, D. Sciarrino, J.C. Sens, L. Servoli, S. Shevchenko, N. Shivarov, V. Shoutko, J. Shukla, E. Shumilov, T. Siedenburg, D. Son, A. Sopczak, V. Soulimov, B. Smith, P. Spillantini, M. Steuer, D.P. Stickland, F. Sticozzi, H. Stone, B. Stoyanov, A. Straessner, K. Strauch, K. Sudhakar, G. Sultanov, L.Z. Sun, G.F. Susinno, H. Suter, J.D. Swain, X.W. Tang, L. Tauscher, L. Taylor, Samuel C.C. Ting, S.M. Ting, O. Toker, F. Tonisch, M. Tonutti, S.C. Tonwar, J. Tóth, A. Tsaregorodtsev, C. Tully, H. Tuchscherer, K.L. Tung, J. Ulbricht, U. Uwer, E. Valente, R.T. Van de Walle, I. Vetlitsky, G. Viertel, M. Vivargent, R. Völkert, H. Vogel, H. Vogt, I. Vorobiev, A.A. Vorobyov, An.A. Vorobyov, A. Vorvolakos, M. Wadhwa, W. Wallraff, J.C. Wang, X.L. Wang, Y.F. Wang, Z.M. Wang, A. Weber, F. Wittgenstein, S.X. Wu, S. Wynhoff, J. Xu, Z.Z. Xu, B.Z. Yang, C.G. Yang, X.Y. Yao, J.B. Ye, S.C. Yeh, J.M. You, C. Zaccardelli, An. Zalite, P. Zemp, J.Y. Zeng, Y. Zeng, Z. Zhang, Z.P. Zhang, B. Zhou, G.J. Zhou, Y. Zhou, G.Y. Zhu, R.Y. Zhu, and A. Zichichi

Subjects
Physics, Nuclear and High Energy Physics, Range (particle radiation), Particle physics, Luminosity (scattering theory), Muon, Photon, 010308 nuclear & particles physics, Detector, Charge (physics), 7. Clean energy, 01 natural sciences, Resonance (particle physics), Nuclear physics, Pair production, 0103 physical sciences, High Energy Physics::Experiment, 010306 general physics
Abstract

Using the data recorded with the L3 detector at LEP, we study the process e + e − → μ + μ − ( γ ) for events with hard initial-state photon radiation. The effective centre-of-mass energies of the muons range from 50 GeV to 86 GeV. The data sample corresponds to an integrated luminosity of 103.5 pb −1 and yields 293 muon-pair events with a hard photon along the beam direction. The events are used to determine the cross sections and the forward-backward charge asymmetries at centre-of-mass energies below the Z resonance.

Published
1996

47. Study of the structure of hadronic events and determination of αS at

Author

Pablo Garcia-Abia, Alain Hervé, Roberto Battiston, P. Marchesini, A. Bay, V. Brigljevic, Gerjan Bobbink, B. Borgia, Carlo Civinini, J. Ulbricht, G. Forconi, Gerard Fernandez, M. Maolinbay, G. Raven, A. Marin, S. Pensotti, B. De La Cruz, Raffaello D'Alessandro, M. Rescigno, M. Aguilar-Benitez, Igor Vorobiev, G. Hu, P. Levtchenko, H. Postema, Leonardo Merola, Panos A Razis, R. T. Van de Walle, I. Clare, H. De Boeck, L. Tauscher, Y. J. Pei, Carlos Willmott, T. Azemoon, B. Lindemann, Speranza Falciano, E. Dénes, P. Pistolesi, O. Toker, T. Paul, S. Costantini, T. Siedenburg, Marcos Cerrada, Y. G. Kim, Peter H. Fisher, Roberto Castello, S. Reucroft, A. Kasser, Y. Zhou, G. Gratta, Y. Karyotakis, Y. Mi, Peter Denes, O. Rind, D.W. Schmitz, G. Pascale, Y. H. Chang, N. Shivarov, Claudio Luci, Robert Clare, A. Arefiev, R. R. McNeil, J. Berdugo, L. Z. Sun, George Alverson, Marco Pieri, E. J. Sanchez, Tariq Aziz, M. Möller, J. S. Kapustinsky, W. G. Ma, Thomas Hebbeker, I. Dorne, M. Redaelli, G. Landi, Paul Lecoq, R. W. Kraemer, M. Napolitano, S. Petrak, Francesca Cavallari, C. Leggett, H. F. Chen, R. Leiste, E. Valente, Pierluigi Paolucci, M. Gailloud, L. Fredj, U. K. Chaturvedi, D. McNally, Christoph Paus, Lamberto Luminari, Yu. Galaktionov, A. Buytenhuijs, E. Brambilla, Y. S. Lu, C. Burgos, D. Duchesneau, H. S. Chen, T. E. Coan, L. J. Gutay, L. Servoli, J. G. Branson, S. S. Gau, Dimitri Bourilkov, W. Lu, Yuri Efremenko, G. Chiefari, S. Shevchenko, Federico Cindolo, S. Mangla, Valery Schegelsky, Antonino Zichichi, F. Ferroni, V. Pojidaev, M. Schneegans, U. Becker, I. Duran, H. Rykaczewski, Giovanni Organtini, J. H. Field, C. Y. Chien, J. Alcaraz, Y. Zeng, J. P. Ernenwein, S. X. Wu, R. C. Ball, Davide Piccolo, A. Kirkby, F. Behner, Andrea Baschirotto, K. Riles, P. Spillantini, S. N. Ganguli, J. D. Swaint, F. Marzano, B. Stoyanov, Bryan R. Smith, B. Monteleoni, F. Sticozzi, Alessandra Doria, Simone Paoletti, Suchandra Dutta, J. P. Martin, G. Coignet, W. Krenz, G. Y. Zhu, E. Shumilov, A. Lebedev, Dong-Chul Son, T. Kramer, J. J. Blaising, F. J. Eppling, G. J. Zhou, L. W. Jones, Stefano Giagu, Cheng Chen, A. Mihul, P. Extermann, S. Schmidt-Kaerst, Salvatore Mele, F. J. Rodriguez, H. R. Gustafson, M. Lebeau, S. C. Tonwar, S. Röhner, S. M. Ting, J. S. Lee, A. Degré, C. Zaccardelli, Werner Lustermann, R. Barillère, V. Shoutko, K. Sudhakar, W. C. van Hoek, Frank Filthaut, Hans J. Vogel, S. Morganti, J. C. Sens, B. C. Riemers, P. Lecomte, J. Schwenke, Christoph Schäfer, B. Z. Yang, Ren-Yuan Zhu, Luciano Barone, D. Antreasyan, Crisostomo Sciacca, F. Wittgenstein, W. W. Kinnison, S. C. Yeh, M. Rattaggi, L. Ludovici, A. Adam, D. Pandoulas, M. von der Mey, Thomas Ferguson, N. Scholz, J. Y. Zeng, J. B. Ye, Howard A. Stone, M. Wadhwa, D. J. Schotanus, H. Hofer, W. J. Burger, An.A. Vorobyov, A. Gurtu, F. Tonisch, E. Drago, R. Völkert, A. P. Colijn, M. Tonutti, K. L. Tung, Els Koffeman, V. Commichau, E. Fiandrini, L. Romero, L. Malgeri, B. Schoeneich, H. Schopper, S. C. Blyth, R. Ostonen, G. Passaleva, M. W. Gruenewald, Gianpaolo Carlino, Konrad Deiters, I. Josa-Mutuberria, P. Kapinos, Samuel C.C. Ting, J. Rodin, Marco Meschini, B. Hartmann, J. Tóth, Harvey B Newman, D. Kirkby, Michael Dittmar, O. Adriani, G. Cara Romeo, B. P. Roe, A. Hasan, M. Pauluzzi, Attilio Santocchia, Jean Fay, F. C. Erné, C. Cecchi, P. Schmitz, G. M. Bilei, Alberto Aloisio, A. Ricker, I. Vetlitsky, W. van Rossum, Lucas Taylor, J. Gerald, R. Faccini, P. Duinker, Simonetta Gentile, M. Bourquin, D. Boutigny, K. Strauch, Subir Sarkar, M. G. Alviggi, X. L. Wang, G. G.G. Massaro, A. Chen, L. Urbán, Adrian Biland, M. Campanelli, Christopher George Tully, P. Lebrun, M. Vivargent, K. Freudenreich, A. Bujak, M. Pohl, Joachim Mnich, Nicolas Produit, A. Klimentov, T. Angelescu, R. de Jong, H. Janssen, Kenneth Francis Read, Wolfgang Lohmann, J.V. Allaby, E. Lieb, P. Bartalini, D. Ren, Jasper Kirkby, H. Vogt, B. Bertucci, M. Acciarri, Guo-Ming Chen, M. Sassowsky, A. J.W. van Mil, S. Patricelli, S. C. Kim, U. Uwer, J. Casaus, Yu. Kamyshkov, J. Shukla, X. W. Tang, D. DiBitonto, A. Robohm, D. van Dierendonck, Nicanor Colino, J. Salicio, P. A. Piroué, G. Viertel, B. Zhou, P. Laurikainen, A. Chan, A. Engler, Marcella Diemoz, M. T. Choi, M. Steuer, S. Easo, Kati Lassila-Perini, Francesca Nessi-Tedaldi, V. Plyaskin, J. D. Burger, Giovanni Ambrosi, M. Capell, C. G. Yang, B. C.C. van der Zwaan, G. Rahal-Callot, M. T. Dova, A. Köngeter, K. Banicz, H. S. Fesefeldt, P. G. Rancoita, L. Cifarelli, H. O. Cohn, D. Perret-Gallix, Y. F. Wang, R. Weill, F. Muheim, C. Maña, I. C. Brock, Paolo Bagnaia, K. Schultze, H. Suter, B. N. Jin, A. Böhm, H. Nowak, A. C. Weber, A. Buijs, G. Mirabelli, V. Soulimov, W. Wallraff, K. Lübelsmeyer, S. Banerjee, Zp Zhang, A. Pevsner, Egidio Longo, H. Tuchscherer, R. Fabbretti, C. Lapoint, A. Kunin, Roger Moore, Georgi Sultanov, T. S. Dai, R. A. Khan, V. P. Andreev, M. Chemarin, G. M. Chen, Aaron Dominguez, Felicitas Pauss, S. Rosier-Lees, P. Le Coultre, M. Basile, K. Hangarter, J. K. Kim, D. Luckey, Gy L. Bencze, Reinhard W. Schulte, M. M. Ilyas, Hafeez R Hoorani, A. Straessner, Luca Lista, W. J. Metzger, S. Goldfarb, D. Fernandez, Juven Wang, J. T. He, F. L. Linde, Willis Lin, Sabine Riemann, H. El Mamouni, F. Di Lodovico, A. M. Cartacci, R. Raghavan, A. C. König, Laurent Vuilleumier, D. Goujon, Andre Sopczak, Vincenzo Innocente, Joel Goldstein, H. Anderhub, S. P. Ahlen, P. Zemp, R. de Asmundis, A. Favara, Z. A. Liu, Z. Z. Xu, X. Y. Yao, J. G. Xu, M. Lenti, Stefan Roth, Dai-Sik Kim, J. M. Le Goff, N. Gheordanescu, P. G. Seiler, J. A. Rubio, S. R. Hou, F. Cesaroni, M. Chamizo, B. Alpat, Emilio Leonardi, B. L. Betev, R. Bock, L. Baksay, F. Cotorobai, Kajari Mazumdar, S. Müller, Xd Cai, C-Q. Li, V. K. Gupta, S. Ro, F. DeNotaristefani, A. Macchiolo, Manas Maity, J. M. Salicio, P. Berges, Steve Nahn, R. Mount, Nicola Cavallo, H. K. Park, A. Nippe, G. Castellini, Alexander Malinin, Z. F. Gong, H. Kuijten, M. N. Kienzle-Focacci, An. Zalite, A. Tsaregorodtsev, Maurizio Biasini, Marta Felcini, K. Y. Lee, Francesco Becattini, Gobinda Majumder, W. Kittel, E. Gonzalez, E. Nagy, S. Wynhoff, M. Fabre, P. Rosselet, J. M. You, M. Caria, D. P. Stickland, A. Koulbardis, V. Koutsenko, Zheng Wang, Zhenyu Zhang, X. Chereau, M. E. Sarakinos, P. Ladron de Guevara, A. Gougas, G. Schwering, G. F. Susinno, J. C. Pinto, Manjit Kaur, J. Busenitz, A. Boucham, and C. Dionisi

Subjects
Quantum chromodynamics, Physics, Nuclear and High Energy Physics, Particle physics, High energy, Luminosity (scattering theory), 010308 nuclear & particles physics, Electron–positron annihilation, High Energy Physics::Phenomenology, Hadron, Structure (category theory), 01 natural sciences, Nuclear physics, 0103 physical sciences, Strong coupling, High Energy Physics::Experiment, 010306 general physics, Event (particle physics)
Abstract

We present a study of the structure of hadronic events recorded by the L3 detector at center-of-mass energies of 130 and 136 GeV. The data sample corresponds to an integrated luminosity of 5 pb-1 collected during the high energy run of 1995. The shapes of the event shape distributions and the energy dependence of their mean values are well reproduced by QCD models. From a comparison of the data with resummed O(alpha_s^2) QCD calculations, we determine the strong coupling constant to be alpha_s(133 GeV) = 0.107 +/- 0.005(exp) +/- 0.006(theor).

Published
1996

48. Search for excited leptons in e+e− annihilation at = 130-140

Author

M. Acciarri, A. Adam, O. Adriani, M. Aguilar-Benitez, S. Ahlen, B. Alpat, J. Alcaraz, J. Allaby, A. Aloisio, G. Alverson, M.G. Alviggi, G. Ambrosi, H. Anderhub, V.P. Andreev, T. Angelescu, D. Antreasyan, A. Arefiev, T. Azemoon, T. Aziz, P. Bagnaia, L. Baksay, R.C. Ball, S. Banerjee, K. Banicz, R. Barillère, L. Barone, P. Bartalini, A. Baschirotto, M. Basile, R. Battiston, A. Bay, F. Becattini, U. Becker, F. Behner, Gy.L. Bencze, J. Berdugo, P. Berges, B. Bertucci, B.L. Betev, M. Biasini, A. Biland, G.M. Bilei, J.J. Blaising, S.C. Blyth, G.J. Bobbink, R. Bock, A. Böhm, B. Borgia, A. Boucham, D. Bourilkov, M. Bourquin, D. Boutigny, E. Brambilla, J.G. Branson, V. Brigljevic, I.C. Brock, A. Buijs, A. Bujak, J.D. Burger, W.J. Burger, C. Burgos, J. Busenitz, A. Buytenhuijs, X.D. Cai, M. Campanelli, M. Capell, G. Cara Romeo, M. Caria, G. Carlino, A.M. Cartacci, J. Casaus, G. Castellini, R. Castello, F. Cavallari, N. Cavallo, C. Cecchi, M. Cerrada, F. Cesaroni, M. Chamizo, A. Chan, Y.H. Chang, U.K. Chaturvedi, M. Chemarin, A. Chen, C. Chen, G. Chen, G.M. Chen, H.F. Chen, H.S. Chen, X. Chereau, G. Chiefari, C.Y. Chien, M.T. Choi, L. Cifarelli, F. Cindolo, C. Civinini, I. Clare, R. Clare, T.E. Coan, H.O. Cohn, G. Coignet, A.P. Colijn, N. Colino, V. Commichau, S. Costantini, F. Cotorobai, B. de la Cruz, T.S. Dai, R. D'Alessandro, R. de Asmundis, H. De Boeck, A. Degré, K. Deiters, E. Dénes, P. Denes, F. DeNotaristefani, D. DiBitonto, M. Diemoz, D. van Dierendonck, F. Di Lodovico, C. Dionisi, M. Dittmar, A. Dominguez, A. Doria, I. Dorne, M.T. Dova, E. Drago, D. Duchesneau, P. Duinker, I. Duran, S. Dutta, S. Easo, Yu. Efremenko, H. El Mamouni, A. Engler, F.J. Eppling, F.C. Erné, J.P. Ernenwein, P. Extermann, R. Fabbretti, M. Fabre, R. Faccini, S. Falciano, A. Favara, J. Fay, M. Felcini, T. Ferguson, D. Fernandez, G. Fernandez, F. Ferroni, H. Fesefeldt, E. Fiandrini, J.H. Field, F. Filthaut, P.H. Fisher, G. Forconi, L. Fredj, K. Freudenreich, M. Gailloud, Yu. Galaktionov, S.N. Ganguli, P. Garcia-Abia, S.S. Gau, S. Gentile, J. Gerald, N. Gheordanescu, S. Giagu, S. Goldfarb, J. Goldstein, Z.F. Gong, E. Gonzalez, A. Gougas, D. Goujon, G. Gratta, M.W. Gruenewald, V.K. Gupta, A. Gurtu, H.R. Gustafson, L.J. Gutay, K. Hangarter, B. Hartmann, A. Hasan, J.T. He, T. Hebbeker, A. Hervé, W.C. van Hoek, H. Hofer, H. Hoorani, S.R. Hou, G. Hu, M.M. Ilyas, V. Innocente, H. Janssen, B.N. Jin, L.W. Jones, P. de Jong, I. Josa-Mutuberria, A. Kasser, R.A. Khan, Yu. Kamyshkov, P. Kapinos, J.S. Kapustinsky, Y. Karyotakis, M. Kaur, M.N. Kienzle-Focacci, D. Kim, J.K. Kim, S.C. Kim, Y.G. Kim, W.W. Kinnison, A. Kirkby, D. Kirkby, J. Kirkby, W. Kittel, A. Klimentov, A.C. König, E. Koffeman, A. Köngeter, V. Koutsenko, A. Koulbardis, R.W. Kraemer, T. Kramer, W. Krenz, H. Kuijten, A. Kunin, P. Ladron de Guevara, G. Landi, C. Lapoint, K. Lassila-Perini, P. Laurikainen, M. Lebeau, A. Lebedev, P. Lebrun, P. Lecomte, P. Lecoq, P. Le Coultre, J.S. Lee, K.Y. Lee, C. Leggett, J.M. Le Goff, R. Leiste, M. Lenti, E. Leonardi, P. Levtchenko, C. Li, E. Lieb, W.T. Lin, F.L. Linde, B. Lindemann, L. Lista, Z.A. Liu, W. Lohmann, E. Longo, W. Lu, Y.S. Lu, K. Lübelsmeyer, C. Luci, D. Luckey, L. Ludovici, L. Luminari, W. Lustermann, W.G. Ma, A. Macchiolo, M. Maity, G. Majumder, L. Malgeri, A. Malinin, C. Maña, S. Mangla, M. Maolinbay, P. Marchesini, A. Marin, J.P. Martin, F. Marzano, G.G.G. Massaro, K. Mazumdar, D. McNally, R.R. McNeil, S. Mele, L. Merola, M. Meschini, W.J. Metzger, M. von der Mey, Y. Mi, A. Mihul, A.J.W. van Mil, G. Mirabelli, J. Mnich, M. Möller, B. Monteleoni, R. Moore, S. Morganti, R. Mount, S. Müller, F. Muheim, E. Nagy, S. Nahn, M. Napolitano, F. Nessi-Tedaldi, H. Newman, A. Nippe, H. Nowak, G. Organtini, R. Ostonen, D. Pandoulas, S. Paoletti, P. Paolucci, H.K. Park, G. Pascale, G. Passaleva, S. Patricelli, T. Paul, M. Pauluzzi, C. Paus, F. Pauss, Y.J. Pei, S. Pensotti, D. Perret-Gallix, S. Petrak, A. Pevsner, D. Piccolo, M. Pieri, J.C. Pinto, P.A. Piroué, E. Pistolesi, V. Plyaskin, M. Pohl, V. Pojidaev, H. Postema, N. Produit, R. Raghavan, G. Rahal-Callot, P.G. Rancoita, M. Rattaggi, G. Raven, P. Razis, K. Read, M. Redaelli, D. Ren, M. Rescigno, S. Reucroft, A. Ricker, S. Riemann, B.C. Riemers, K. Riles, O. Rind, S. Ro, A. Robohm, J. Rodin, F.J. Rodriguez, B.P. Roe, S. Röhner, L. Romero, S. Rosier-Lees, Ph. Rosselet, W. van Rossum, S. Roth, J.A. Rubio, H. Rykaczewski, J. Salicio, J.M. Salicio, E. Sanchez, A. Santocchia, M.E. Sarakinos, S. Sarkar, M. Sassowsky, C. Schäfer, V. Schegelsky, S. Schmidt-Kaerst, D. Schmitz, P. Schmitz, M. Schneegans, B. Schoeneich, N. Scholz, H. Schopper, D.J. Schotanus, R. Schulte, K. Schultze, J. Schwenke, G. Schwering, C. Sciacca, P.G. Seiler, J.C. Sens, L. Servoli, S. Shevchenko, N. Shivarov, V. Shoutko, J. Shukla, E. Shumilov, T. Siedenburg, D. Son, A. Sopczak, V. Soulimov, B. Smith, P. Spillantini, M. Steuer, D.P. Stickland, F. Sticozzi, H. Stone, B. Stoyanov, A. Straessner, K. Strauch, K. Sudhakar, G. Sultanov, L.Z. Sun, G.F. Susinno, H. Suter, J.D. Swain, X.W. Tang, L. Tauscher, L. Taylor, Samuel C.C. Ting, S.M. Ting, O. Toker, F. Tonisch, M. Tonutti, S.C. Tonwar, J. Tóth, A. Tsaregorodtsev, C. Tully, H. Tuchscherer, K.L. Tung, J. Ulbricht, L. Urbán, U. Uwer, E. Valente, R.T. Van de Walle, I. Vetlitsky, G. Viertel, M. Vivargent, R. Völkert, H. Vogel, H. Vogt, I. Vorobiev, A.A. Vorobyov, An.A. Vorobyov, L. Vuilleumier, M. Wadhwa, W. Wallraff, J.C. Wang, X.L. Wang, Y.F. Wang, Z.M. Wang, A. Weber, R. Weill, C. Willmott, F. Wittgenstein, S.X. Wu, S. Wynhoff, J. Xu, Z.Z. Xu, B.Z. Yang, C.G. Yang, X.Y. Yao, J.B. Ye, S.C. Yeh, J.M. You, C. Zaccardelli, An. Zalite, P. Zemp, J.Y. Zeng, Y. Zeng, Z. Zhang, Z.P. Zhang, B. Zhou, G.J. Zhou, Y. Zhou, G.Y. Zhu, R.Y. Zhu, A. Zichichi, and B.C.C. van der Zwaan

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Annihilation, 010308 nuclear & particles physics, Electron–positron annihilation, Electron, 7. Clean energy, 01 natural sciences, Nuclear physics, Excited state, 0103 physical sciences, High Energy Physics::Experiment, Neutrino, Nuclear Experiment, 010306 general physics, Lepton
Abstract

We report on a search for the excited leptons e ∗ , μ ∗ , τ ∗ and ν ∗ in e + e − collisions at s = 130-140 GeV using the L3 detector at LEP. No evidence has been found for their existence. From an analysis of the expected pair produced l ∗ l ∗ in the channels eeγγ, μμγγ, ττγγ, eeWW, and ννγγ, we determine the lower mass limits at 95% C.L. of 64.7 GeV for e ∗ , 64.9 GeV for μ ∗ , 64.2 GeV for τ ∗ , 57.3 GeV (eW decay mode) and 61.4 GeV (νγ decay mode) for ν ∗ . From an analysis of the expected singly produced ll ∗ in the channels eeγ, μμγ, ττγ, νeW and ννγ, we determine upper limits on the couplings λ m l ∗ up to m l ∗ = 130 GeV .

Published
1996

49. Changes in IP3 and cytosolic Ca2+ in response to sugars and non-sugar sweeteners in transduction of sweet taste in the rat

Author

Michael Naim, U Zehavi, S J Bernhardt, and B Lindemann

Subjects
Male, Sucrose, Physiology, Carbohydrates, Stimulation, Inositol 1,4,5-Trisphosphate, In Vitro Techniques, Exocytosis, Amiloride, Rats, Sprague-Dawley, chemistry.chemical_compound, Saccharin, Cyclic AMP, Image Processing, Computer-Assisted, Extracellular, Animals, Inositol, Cyclic adenosine monophosphate, Gallopamil, Fluorescent Dyes, Forskolin, Colforsin, Taste Buds, Rats, Quaternary Ammonium Compounds, Microscopy, Fluorescence, chemistry, Biochemistry, Metals, Sweetening Agents, Calcium, Fura-2, Signal Transduction, Research Article
Abstract

1. The transduction pathways of sweet-sensitive cells in rat circumvallate (CV) taste buds were investigated with assays for inositol 1,4,5-trisphosphate (IP3) and with Ca2+ imaging. Stimulation with the non-sugar sweeteners SC-45647 and saccharin rapidly increased the cellular content of IP3 by 400 pmol (mg protein)-1, while sucrose had a much smaller effect on IP3. As shown previously, sucrose, but not saccharin, increased the content of cyclic adenosine monophosphate (cAMP) of this preparation. 2. Stimulation of isolated CV taste buds with SC-45647 increased the cytosolic Ca2+ concentration ([Ca2+]i) by 56.7 +/- 3.2 nM (n = 181). Due to the non-confocality of the measuring system, these concentrations are underestimates. The increase in [Ca2+]i did not require the presence of extracellular Ca2+, suggesting that the Ca2+ release was from intracellular stores. 3. Individual cells responding to the non-sugar sweeteners with Ca2+ release also responded to sucrose and to forskolin with an increase in [Ca2+]i. Such cells did not respond to the bitter tastant denatonium chloride. 4. Responses to sucrose were abolished by lowering the Ca2+ concentration of the stimulus solution, indicating Ca2+ uptake from the extracellular medium. 5. The responses of sweet-sensitive cells to forskolin were also abolished when Ca2+ ions were omitted from the stimulus solution. They were partially inhibited by the presence of Co2+, Ni2+, D600 (methoxyverapamil) and amiloride, indicating multiple pathways of Ca2+ uptake activated by cAMP. 6. In conclusion, a sweet-sensitive cell of the rat responds to sucrose with an increase in cAMP and Ca2+ uptake, but to non-sugar sweeteners with an increase in IP3 and Ca2+ release. The increase in [Ca2+]i, common to both pathways, is presumably required for synaptic exocytosis and for signal termination.

Published
1996

50. Search for supersymmetric particles at 130 GeV<root s<140 GeV at LEP

Author

M. Acciarri, A. Adam, O. Adriani, M. AguilarBenitez, S. Ahlen, B. Alpat, J. Alcaraz, G. Alemanni, J. Allaby, G. Alverson, G. Ambrosi, H. Anderhub, V. P. Andreev, T. Angelescu, D. Antreasyan, A. Arefiev, T. Azemoon, T. Aziz, P. Bagnaia, L. Baksay, R. C. Ball, S. Banerjee, K. Banicz, R. Barillere, L. Barone, P. Bartalini, A. Baschirotto, M. Basile, R. Battiston, A. Bay, F. Becattini, U. Becker, F. Behner, J. Berdugo, P. Berges, B. Bertucci, B. L. Betev, M. Biasini, A. Biland, G. M. Bilei, J. J. Blaising, S. C. Blyth, G. J. Bobbink, R. Bock, A. Bohm, B. Borgia, A. Boucham, D. Bourilkov, M. Bourquin, E. Brambilla, J. G. Branson, V. Brigljevic, I. C. Brock, A. Buijs, A. Bujak, J. D. Burger, W. J. Burger, J. Busenitz, A. Buytenhuijs, X. D. Cai, M. Campanelli, M. Capell, G. C. Romeo, M. Caria, G. Carlino, A. M. Cartacci, J. Casaus, G. Castellini, R. Castello, F. Cavallari, N. Cavallo, C. Cecchi, M. Cerrada, F. Cesaroni, M. Chamizo, A. Chan, Y. H. Chang, U. K. Chaturvedi, M. Chemarin, A. Chen, C. Chen, G. Chen, G. M. Chen, H. F. Chen, H. S. Chen, X. Chereau, C. Y. Chien, M. T. Choi, L. Cifarelli, F. Cindolo, C. Civinini, I. Clare, R. Clare, H. O. Cohn, G. Coignet, A. P. Colijn, N. Colino, V. Commichau, S. Costantini, F. Cotorobai, B. delaCruz, T. S. Dai, D. DAlessandro, R. deAsmundis, H. DeBoeck, A. Degre, K. DEiters, P. Denes, F. Denotaristefani, D. DiBitonto, M. Diemoz, D. vanDierendonck, F. DiLodovico, C. Dionisi, M. Dittmar, A. Dominguez, A. Doria, I. Dorne, M. T. Dova, E. Drago, D. Duchesneau, P. Duinker, I. Duran, S. Dutta, S. Easo, Y. Efremenko, H. ElMamouni, A. Engler, F. J. Eppling, F. C. Erne, J. P. Ernenwein, P. Extermann, M. Fabre, R. Faccini, S. Falciano, A. Favara, J. Fay, M. Felcini, T. Ferguson, D. Fernandez, F. Ferroni, H. Fesefeldt, E. Fiandrini, J. H. Field, F. Filthaut, P. H. Fisher, G. Forconi, L. Fredj, K. Freudenreich, Y. Galaktionov, S. N. Ganguli, S. S. Gau, S. Gentile, J. Gerald, N. Gheordanescu, S. Giagu, S. Goldfarb, J. Goldstein, Z. F. Gong, A. Gougas, G. Gratta, M. W. Gruenewald, V. K. Gupta, A. Gurtu, L. J. Gutay, K. Hangarter, B. Hartmann, A. Hasan, J. T. He, T. Hebbeker, A. Herve, W. C. vanHoek, H. Hofer, H. Hoorani, S. R. Hou, G. Hu, M. M. Ilyas, V. Innocente, H. Janssen, B. N. Jin, L. W. Jones, P. deJong, I. JosaMutuberria, A. Kasser, R. A. Khan, Y. Kamyshkov, P. Kapinos, J. S. Kapustinsky, Y. Karyotakis, M. Kaur, M. N. KienzleFocacci, D. Kim, J. K. Kim, S. C. Kim, Y. G. Kim, W. W. Kinnison, A. Kirkby, D. Kirkby, J. Kirkby, W. Kittel, A. Klimentov, A. C. Konig, A. Kongeter, I. Korolko, V. Koutsenko, A. Koulbardis, R. W. Kraemer, T. Kramer, W. Krenz, H. Kuijten, A. Kunin, P. L. deGuevara, G. Landi, C. Lapoint, K. LassilaPerini, M. Lebeau, A. Lebedev, P. Lebrun, P. Lecomte, P. Lecoq, P. LeCoultre, J. S. Lee, K. Y. Lee, J. M. LeGoff, R. Leiste, M. Lenti, E. Leonardi, P. Levtchenko, C. Li, E. Lieb, W. T. Lin, F. L. Linde, B. Lindemann, L. Lista, Z. A. Liu, W. Lohmann, E. Longo, W. Lu, Y. S. Lu, K. Lubelsmeyer, C. Luci, D. Luckey, L. Ludovici, L. Luminari, W. Lustermann, W. G. Ma, A. Macchiolo, M. Maity, G. Majumder, L. Malgeri, A. Malinin, C. Mana, S. Mangla, P. Marchesini, A. Marin, J. P. Martin, F. Marzano, G. G. G., K. Mazumdar, D. McNally, R. R. McNeil, S. Mele, M. Meschini, W. J. Metzger, M. vonderMey, Y. Mi, A. Mihul, A. J. W., G. Mirabelli, J. Mnich, M. Moller, B. Monteleoni, R. MOore, S. Morganti, R. Mount, S. Muller, F. Mulheim, E. Nagy, S. Nahn, F. NessiTedaldi, H. Newman, A. Nippe, H. Nowak, G. Organtini, R. Ostonen, D. Pandoulas, S. Paoletti, P. Paolucci, H. K. Park, G. Pascale, G. Passaleva, T. Paul, M. Pauluzzi, C. Paus, F. Pauss, D. Peach, Y. J. Pei, S. Pensotti, D. PerretGallix, S. Petrak, A. Pevsner, D. Piccolo, M. Pieri, J. C. Pinto, P. A. Piroue, E. Pistolesi, V. Plyaskin, M. Pohl, V. Pojidaev, H. Postema, N. Produit, R. Raghavan, G. RahalCallot, P. G. Rancoita, M. Rattaggi, G. Raven, P. Razis, K. Read, M. Redaelli, D. Ren, M. Rescigno, S. Reucroft, A. Ricker, S. Riemann, B. C. Riemers, K. Riles, S. Ro, A. Robohm, J. Rodin, F. J. Rodriguez, B. P. Roe, S. Rohner, L. Romero, S. RosierLees, P. Rosselet, W. vanRossum, S. Roth, J. A. Rubio, H. Rykaczewski, J. Salicio, E. Sanchez, A. Santocchia, M. E. Sarakinos, S. Sarkar, M. Sassowsky, C. Schafer, V. Schegelsky, S. SchmidtKaerst, D. Schmitz, P. Schmitz, M. Schneegans, B. Schoeneich, N. Scholz, H. Schopper, D. J. Schotanus, R. Schulte, K. Schultze, J. Schwenke, G. Schwering, D. SCiarrino, J. C. Sens, L. Servoli, S. Shevchenko, N. Shivarov, V. Shoutko, J. Shukla, E. Shumilov, T. Siedenburg, D. Son, A. Sopczak, B. Smith, P. Spillantini, M. Steuer, D. P. Strickland, F. Sticozzi, H. Stone, B. Stoyanov, A. Straessner, K. Strauch, K. Sudhakar, G. Sultanov, L. Z. Sun, G. F. Susinno, H. Suter, J. D. Swain, X. W. Tang, L. Tauscher, L. Taylor, S. C. C., S. M. Ting, O. Toker, F. Tonisch, M. Tonutti, S. C. Tonwar, J. Toth, A. Tsaregorodtsev, C. Tully, H. Tuchscherer, K. L. Tung, J. Ulbricht, U. Uwer, E. Valente, R. T. VandeWAlle, I. Vetlitsky, G. Viertel, M. Vivargent, R. Volkert, H. Vogel, H. Vogt, I. Vorobiev, A. A. Vorobyov, A. Vorvolakos, M. Wadhwa, W. Wallraff, J. C. Wang, X. L. Wang, Y. F. Wang, Z. M. WAng, A. Weber, F. Wittgenstein, S. X. Wu, S. Wynhoff, J. Xu, Z. Z. Xu, B. Z. Yang, C. G. Yang, X. Y. Yao, J. B. Ye, S. C. Yeh, J. M. You, C. Zaccardelli, A. Zalite, P. Zemp, J. Y. Zeng, Y. Zeng, Z. Zhang, Z. P. Zhang, B. Zhou, G. J. Zhou, Y. Zhou, G. Y. Zhu, R. Y. Zhu, A. Zichichi, ALOISIO, ALBERTO, ALVIGGI, MARIAGRAZIA, CHIEFARI, GIOVANNI, MEROLA, LEONARDO, NAPOLITANO, MARCO, PATRICELLI, SERGIO, SCIACCA, CRISOSTOMO, Acciarri, M., Adam, A., Adriani, O., Aguilarbenitez, M., Ahlen, S., Alpat, B., Alcaraz, J., Alemanni, G., Allaby, J., Aloisio, Alberto, Alverson, G., Alviggi, Mariagrazia, Ambrosi, G., Anderhub, H., Andreev, V. P., Angelescu, T., Antreasyan, D., Arefiev, A., Azemoon, T., Aziz, T., Bagnaia, P., Baksay, L., Ball, R. 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Subjects
E+E-PHYSICS, LUND MONTE-CARLO, SUPERGRAVITY, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), JET FRAGMENTATION, DECAYS
Abstract

A search for supersymmetric particles (charginos, neutralinos, sleptons and stop quarks) has been performed with data collected by the L3 detector during the November 1995 run of the LEP collider at centre of mass energies between 130 and 140 GeV with a total integrated luminosity of 5.1 pb(-1). We observe no signal for supersymmetric particles and we set improved exclusion limits on their production cross sections and masses.

Published
1996

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