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1. Contents Vol. 73, 2007

Author

C.E. Nwogu, A.N. Tenekeci, Pierre Michel, Michihide Mitsumori, Kohkichi Hata, Mariana Capurro, S. Maddipatla, R.V. Iyer, Eiji Miyoshi, H.J. Stemmler, Rosangela Romano, A. Douglas-Jones, B. Kalischefski, Sylvie Negrier, D. Laessig, J. Robson, Domenico Germano, Wong Benjamin Chun Yu, Torello Lotti, Chen Minhu, Peixing Wu, Jie Zhang, G. Paganelli, Metin Karakok, Rafael Roesler, P.A. Fasching, Toshinao Onoda, Takatsugu Kan, Tsuneo Tanaka, Hideyuki Ohnuma, Yasuhito Tonomoto, M. Stauch, Sung Ho Choi, Hui Yan Li, R.E. Mansel, C. Poettgen, S. Raj, Yan Wang, Daniela Massi, Xiaoyan Yang, Thomas Krbek, B. Sakar, Bülent Akgul, H. Kynaston, Dipok Kumar Dhar, H. Kölbl, Satoshi Shiojima, Vincenzo De Giorgi, J.D. Black, Bin Zhou, Evangelos Karayiotis, Seungmin Bang, Hong-zhi Luo, Akira Myoumoto, Bing Xu, Hitoshi Nobumasa, Pu Wang, Serena Sestini, Go Watanabe, Yutaka Shimada, Ibrahim Sari, S.R. Davies, Tadashi Kadowaki, Si Young Song, Shinichi Miyamoto, Meletios A. Dimopoulos, Bai Aiping, G. Loewen, P. Maubach, Akira Miyauchi, Shen Benchang, F. Melchert, Shigemi Matsumoto, G. Morack, J. Alkhaddo, N. Natarajan, Atsushi Itami, Zong-guang Zhou, Luise Meurer, Lie Yang, Hai-yi Liu, Naofumi Nagasue, Kanako Yamanaka, Dirk Theegarten, Giulia Lo Russo, Gazi Comez, Aristotle Bamias, M.E. Reid, David Tougeron, Efstathios Kastritis, Eiji Tanaka, A. Chhabra, Sabine Levegruen, Marios Froudarakis, Andreas Koureas, Celalettin Camci, Yavuz Pehlivan, Jeong Youp Park, F. Eid, Dirk Jaeger, Gozoh Tsujimoto, N. Ramnath, A.U. Pande, G. Watkins, H.S. Fernando, H. Meerpohl, Mehmet Emin Kalender, Katsuhisa Noda, Helmut Teschler, Gilberto Schwartsmann, Xiao-Feng Sun, Genny Leporatti, M.A. Ustaoglu, Tetsuo Ito, Martin Stuschke, V. Heinemann, Alper Sevinc, Toshinori Sato, Noriko Okuyama, Bernard Paillot, Olivier Rigal, Yuan Li, Andreas Bockisch, M. Basaran, Nikos Antoniou, P. Dua, Sadako Yamagata, D. Mazhar, Hiroshi Yoshida, Wolfgang Stremmel, S. Saglam, Mei Hou, Wilfried Eberhardt, R.J. Menezes, N.F. Aykan, Michael Chrisofos, Hitoshi Matsumoto, C.M. Levea, Anastassios V. Koutsopoulos, Georgios Stamatis, Hideo Akiyama, Li Xiaoyan, Ling Wang, H. Hamidou, Maurie Markman, Luigi Manzione, Andreas Skolarikos, Yu-jian Zeng, Mario Dini, Jorge Filmus, A.K. Dixon, Frédéric Di Fiore, Daniela Baumann Cornelio, M. Emin Kalender, Stephen J. Meltzer, Wang Jinhui, A. Argon, Tatsuya Yamagata, M. Gumus, Motoshige Higashiyama, B. Weber, Song Xin, G. Alivizatos, Jiang Zhu, Sung Hoon Noh, Thomas Gauler, Yasuhiro Ito, Thomas R. W. Herrmann, Christina Herrmann, Jinghai Zhang, Yong Soo Kim, U. Vehling-Kaiser, H. Mehmet Turk, Z. Ustuner, Hilmar Kuehl, Christelle De La Fouchardiere, Chen Huixin, Woo Jin Hyung, Georgia Karpathiou, M.M. Javle, Olivia Diaz, Evangelia Argiana, A. Scharl, Ulrich Abel, George Lainakis, Fumiaki Sato, W.G. Jiang, M.V. Williams, Romain Coriat, G.Y. Yang, N. Guney, Shiori Tomoda, A. Rani, Françoise Desseigne, Jun-min Song, and Mitsuo Tachibana

Subjects
Cancer Research, Oncology, General Medicine
Published
2007
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2. Gemcitabine and carboplatin in intensively pretreated patients with metastatic breast cancer

Author

Ursula Vehling-Kaiser, Hans-Joachim Stemmler, A. Scharl, H. Kölbl, G. Morack, Volker Heinemann, B. Kalischefski, P. Maubach, F. Melchert, B. Weber, Martina Stauch, Peter A. Fasching, D. Laessig, and Hans-Gerd Meerpohl

Subjects
Oncology, Adult, Cancer Research, medicine.medical_specialty, medicine.drug_class, Medizinische Fakultät -ohne weitere Spezifikation, Breast Neoplasms, Antimetabolite, Deoxycytidine, Metastasis, Carboplatin, chemistry.chemical_compound, Breast cancer, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, ddc:610, Neoplasm Metastasis, skin and connective tissue diseases, Aged, Neoplasm Staging, Dose-Response Relationship, Drug, business.industry, Patient Selection, Cancer, General Medicine, Middle Aged, medicine.disease, Metastatic breast cancer, Thrombocytopenia, Gemcitabine, Surgery, chemistry, Female, Breast disease, business, medicine.drug
Abstract

Background: Patients with metastatic breast cancer (MBC) are increasingly exposed to anthracyclines and taxanes either during treatment of primary breast cancer or during initial therapy of metastatic disease. The combination of gemcitabine and carboplatin was therefore investigated as an anthracycline- and taxane-free treatment option. Patients and Methods: MBC patients previously treated with chemotherapy were enrolled in a multicenter phase II study. Treatment consisted of gemcitabine (1,000 mg/m2 i.v. on days 1 and 8) and carboplatin (AUC 4 i.v. on day 1) applied every 3 weeks. Results: Thirty-nine patients were recruited, and a total of 207 treatment cycles were applied with a median of 5 cycles per patient. One complete response and 11 partial responses were observed for an overall response rate of 31% (95% CI: 17–48%). Twelve patients (31%) had stable disease. Median time to progression was 5.3 months (95% CI: 2.6–6.7 months) and median overall survival from start of treatment was 13.2 months (95% CI: 8.7–16.7 months). Grade 3/4 hematological toxicity included leukopenia (59%/5%), thrombocytopenia (26%/23%) and anemia (10%/0%). Nonhematological toxicity was rarely severe. Conclusion: Combination chemotherapy with gemcitabine and carboplatin is an effective and generally well-tolerated treatment option for intensively pretreated patients with MBC. Due to a considerable incidence of severe thrombocytopenia it would be reasonable to consider starting gemcitabine at the lower dose level of 800 mg/m2.

Published
2007

3. Subject Index Vol. 73, 2007

Author

Serena Sestini, W.G. Jiang, Hideo Akiyama, Maurie Markman, M. Emin Kalender, Kohkichi Hata, Rosangela Romano, M. Basaran, Martin Stuschke, Satoshi Shiojima, Anastassios V. Koutsopoulos, Ibrahim Sari, Zong-guang Zhou, Georgia Karpathiou, M.M. Javle, Christelle De La Fouchardiere, Nikos Antoniou, Jie Zhang, Olivier Rigal, Yavuz Pehlivan, Atsushi Itami, Naofumi Nagasue, Wang Jinhui, N.F. Aykan, Michael Chrisofos, Hitoshi Matsumoto, Wilfried Eberhardt, H. Hamidou, Giulia Lo Russo, R.J. Menezes, Chen Huixin, A. Douglas-Jones, A. Scharl, Helmut Teschler, Romain Coriat, G.Y. Yang, Toshinao Onoda, N. Guney, G. Morack, Gozoh Tsujimoto, Torello Lotti, J. Robson, Li Xiaoyan, J. Alkhaddo, Go Watanabe, Yu-jian Zeng, A.K. Dixon, G. Watkins, Yutaka Shimada, Motoshige Higashiyama, S. Maddipatla, Shiori Tomoda, Ulrich Abel, Eiji Tanaka, Sabine Levegruen, Frédéric Di Fiore, Thomas Krbek, Andreas Skolarikos, Domenico Germano, George Lainakis, Gilberto Schwartsmann, Xiao-Feng Sun, Mehmet Emin Kalender, Tadashi Kadowaki, Si Young Song, A. Argon, Hideyuki Ohnuma, Tatsuya Yamagata, Yasuhito Tonomoto, Alper Sevinc, M. Stauch, Ling Wang, Jiang Zhu, Yuan Li, S.R. Davies, Bai Aiping, Sung Ho Choi, Daniela Baumann Cornelio, Genny Leporatti, A. Rani, U. Vehling-Kaiser, Takatsugu Kan, Yasuhiro Ito, C. Poettgen, Dirk Theegarten, Song Xin, B. Kalischefski, Christina Herrmann, Sylvie Negrier, Mei Hou, Pierre Michel, Bülent Akgul, D. Laessig, Dipok Kumar Dhar, Fumiaki Sato, C.M. Levea, Wolfgang Stremmel, F. Eid, Dirk Jaeger, A.U. Pande, Bin Zhou, Meletios A. Dimopoulos, Woo Jin Hyung, Aristotle Bamias, David Tougeron, D. Mazhar, Hiroshi Yoshida, Bernard Paillot, Luise Meurer, Wong Benjamin Chun Yu, Gazi Comez, H.J. Stemmler, S. Saglam, A. Chhabra, Olivia Diaz, Jeong Youp Park, Evangelia Argiana, Akira Myoumoto, Bing Xu, Thomas Gauler, Hitoshi Nobumasa, Xiaoyan Yang, Tetsuo Ito, M.V. Williams, S. Raj, Toshinori Sato, Luigi Manzione, Mario Dini, H. Mehmet Turk, Jorge Filmus, Chen Minhu, Peixing Wu, Michihide Mitsumori, Z. Ustuner, Katsuhisa Noda, Françoise Desseigne, Jun-min Song, Mariana Capurro, Shen Benchang, Andreas Bockisch, Stephen J. Meltzer, G. Loewen, M.E. Reid, N. Natarajan, R.V. Iyer, Mitsuo Tachibana, Seungmin Bang, Lie Yang, Kanako Yamanaka, H. Kölbl, P. Maubach, Akira Miyauchi, C.E. Nwogu, M.A. Ustaoglu, A.N. Tenekeci, M. Gumus, V. Heinemann, Eiji Miyoshi, B. Weber, Noriko Okuyama, B. Sakar, Shinichi Miyamoto, N. Ramnath, Yan Wang, Shigemi Matsumoto, Rafael Roesler, Sung Hoon Noh, Hui Yan Li, Pu Wang, H. Meerpohl, Daniela Massi, J.D. Black, Georgios Stamatis, Marios Froudarakis, Andreas Koureas, Celalettin Camci, G. Alivizatos, P. Dua, Sadako Yamagata, Thomas R. W. Herrmann, Jinghai Zhang, Vincenzo De Giorgi, Yong Soo Kim, Hilmar Kuehl, Efstathios Kastritis, Evangelos Karayiotis, F. Melchert, Hai-yi Liu, G. Paganelli, R.E. Mansel, Metin Karakok, P.A. Fasching, H. Kynaston, Hong-zhi Luo, H.S. Fernando, and Tsuneo Tanaka

Subjects
Cancer Research, Index (economics), Oncology, Statistics, Subject (documents), General Medicine, Mathematics
Published
2007
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4. Gemcitabine and carboplatin in intensively pretreated patients with metastatic breast cancer.

Author

Laessig D, Stemmler HJ, Vehling-Kaiser U, Fasching PA, Melchert F, Kolbl H, Stauch M, Maubach P, Scharl A, Morack G, Meerpohl H, Weber B, Kalischefski B, and Heinemann V

Subjects
Adult, Aged, Antineoplastic Combined Chemotherapy Protocols toxicity, Deoxycytidine administration & dosage, Dose-Response Relationship, Drug, Female, Humans, Middle Aged, Neoplasm Metastasis, Neoplasm Staging, Patient Selection, Thrombocytopenia chemically induced, Gemcitabine, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Breast Neoplasms drug therapy, Breast Neoplasms pathology, Carboplatin administration & dosage, Deoxycytidine analogs & derivatives
Abstract

Background: Patients with metastatic breast cancer (MBC) are increasingly exposed to anthracyclines and taxanes either during treatment of primary breast cancer or during initial therapy of metastatic disease. The combination of gemcitabine and carboplatin was therefore investigated as an anthracycline- and taxane-free treatment option., Patients and Methods: MBC patients previously treated with chemotherapy were enrolled in a multicenter phase II study. Treatment consisted of gemcitabine (1,000 mg/m(2) i.v. on days 1 and 8) and carboplatin (AUC 4 i.v. on day 1) applied every 3 weeks., Results: Thirty-nine patients were recruited, and a total of 207 treatment cycles were applied with a median of 5 cycles per patient. One complete response and 11 partial responses were observed for an overall response rate of 31% (95% CI: 17-48%). Twelve patients (31%) had stable disease. Median time to progression was 5.3 months (95% CI: 2.6-6.7 months) and median overall survival from start of treatment was 13.2 months (95% CI: 8.7-16.7 months). Grade 3/4 hematological toxicity included leukopenia (59%/5%), thrombocytopenia (26%/23%) and anemia (10%/0%). Nonhematological toxicity was rarely severe., Conclusion: Combination chemotherapy with gemcitabine and carboplatin is an effective and generally well-tolerated treatment option for intensively pretreated patients with MBC. Due to a considerable incidence of severe thrombocytopenia it would be reasonable to consider starting gemcitabine at the lower dose level of 800 mg/m(2)., (2008 S. Karger AG, Basel.)

Published
2007
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