11 results on '"B. K., Bajaj"'
Search Results
2. Autonomic neuropathy in patients with hepatic cirrhosis
- Author
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B K Bajaj, B Krishna Ram, and Manisha Agarwal
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Liver Cirrhosis ,Alcoholic liver disease ,medicine.medical_specialty ,Pathology ,Cirrhosis ,Posture ,Blood Pressure ,Gastroenterology ,Liver disease ,Heart Rate ,Internal medicine ,Heart rate ,medicine ,Humans ,In patient ,business.industry ,Respiration ,Case-control study ,General Medicine ,medicine.disease ,Blood pressure ,Peripheral neuropathy ,Autonomic Nervous System Diseases ,Case-Control Studies ,Original Article ,business - Abstract
Background Autonomic neuropathy has been reported in patients with alcoholic liver disease but information on its occurrence in patients with non-alcoholic liver disease is contradictory. Aim To assess autonomic functions in patients with alcoholic and non-alcoholic liver disease. Study design Autonomic function using five standard tests was examined in 20 cirrhotics (10 alcoholics and 10 non-alcoholics) and 20 age and sex matched controls. The extent of autonomic dysfunction was determined in the patients and a comparison between the characteristics of patients with and without autonomic neuropathy was made. Results Sixteen (80%) of the cirrhotic subjects were found to have evidence of autonomic neuropathy. Of these, three (15%) patients had early parasympathetic damage, five (25%) had definite parasympathetic damage, and eight (40%) had combined (that is, both parasympathetic and sympathetic) damage. Nine (90%) of the alcoholics and seven (70%) of the non-alcoholics had autonomic dysfunction. Only one patient belonging to the alcoholic group had clinical evidence of peripheral neuropathy. Moreover, there was no significant association between subjective symptoms of autonomic neuropathy and objective evidence of autonomic damage as assessed by autonomic function tests. Autonomic dysfunction was significantly more frequent in advanced liver disease compared with early liver damage. Nine (75%) out of 12 cirrhotic subjects belonging to Child class B and six (85.7%) of the seven patients belonging to Child class C had autonomic neuropathy. Conclusion This study shows that autonomic neuropathy is common in cirrhotic subjects, that it is found with comparable frequency in alcoholics and non-alcoholics, and that it increases in severity with increase in extent of liver damage, suggesting that liver damage contributes to the neurological deficit.
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- 2003
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3. Effect of inter-cropping bell-pepper with ginger on plant parasitic nematode populations and crop yields
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B K Bajaj and G. C. Sharma
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Horticulture ,biology ,Tylenchorhynchus ,Agronomy ,Meloidogyne incognita ,Zingiber officinale ,Intercropping ,biology.organism_classification ,Helicotylenchus dihystera ,Agronomy and Crop Science ,Pratylenchus penetrans ,Terra incognita ,Rhizome - Abstract
Summary. During 1994 studies were undertaken to improve ginger (Zingiber officinale Roscoe) yield against the nematodes Pratylenchus penetrans, Meloidogyne incognita, Helicotylenchus dihystera and Tylenchorhynchus mashhoodi in Himachal Pradesh (HP) (India) by inter-cropping bell-pepper (Capsicum annum L) in eight different sequences (treatments). Inter-cropping of “one rhizome of ginger x one plant of bell-pepper” gave the highest ginger yield (600 g per rhizome). This treatment was completely free from P. penetrans and M. incognita. All treatments with bell-pepper plants equal to or higher in number to that of ginger rhizomes had higher ginger yields than treatments with ginger alone or with fewer bell-pepper plants. In the former, populations of P. penetrans and M. incognita were lower than in the latter treatments. The yield of ginger varied irrespective of population densities of H. dihystera and T. mashhoodi, indicating that P. penetrans and M. incognita are the major nematode problems of ginger in HP. Bell-pepper was a non-host to P. penetrans and non-preferred host to M. incognita. This helped to improve ginger yields by making the rhizosphere unfavourable for the development and multiplication of the major ginger nematode pests.
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- 1998
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4. Hypocholesterolemic potential of probiotics: Concept and mechanistic insights.
- Author
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B., Bhat and B. K., Bajaj
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ANTICHOLESTEREMIC agents , *PROBIOTICS , *BLOOD cholesterol , *HYDROLASES ,CARDIOVASCULAR disease related mortality - Abstract
Cardiovascular diseases (CVDs) have become one of the leading causes of global mortality. The raised serum cholesterol levels and its progressive accumulation in arterial walls results in development of atherosclerosis that leads to most of the heart attacks and strokes. Use of probiotics has been implicated for several health benefits including their cholesterol lowering potential and hence management of CVDs. The current review aims to describe the association of gut microbiota, probiotics and their potential mechanisms responsible for hypocholesterolemic effects. Probiotics execute hypocholesterolemic effects through several mechanisms such as bile salt hydrolase activity (BSH), deconjugation of bile salts, cholesterol assimilation, coprecipitation of cholesterol with deconjugated bile salts, removal of cholesterol with cellular surfaces through physical forces, incorporation of cholesterol in the cell membrane of the probiotics, intestinal conversion of cholesterol in coprostanol, and inhibition of Niemann-Pick C1 like 1 (NPC1L1) cholesterol transporter in the enterocytes. However, the health benefits including the hypocholesterolemic effects appear to be a strain specific phenomenon. Further studies are necessary for better understanding of the in-depth molecular mechanisms governing the hypocholesterolemic effects and to establish the probiotics as a potential non-pharmaceutical approach for management of CVDs. [ABSTRACT FROM AUTHOR]
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- 2019
5. Hypersexual features in Huntington's disease
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A, Jhanjee, K S, Anand, and B K, Bajaj
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Adult ,Benzodiazepines ,Sexual Dysfunction, Physiological ,Huntington Disease ,Treatment Outcome ,Olanzapine ,Sexual Behavior ,Haloperidol ,Humans ,Female ,Sexual Dysfunctions, Psychological ,Antipsychotic Agents - Abstract
We report the case of a 30-year-old woman with a rare presentation of early adulthood Huntington's disease (HD) with hypersexuality. It is not known if sexual dysfunction in HD patients is due to a specific brain lesion or adverse psychosocial factors associated with HD. Although there are no evidence-based treatment guidelines for hypersexuality in HD, our patient exhibited significant improvement with olanzapine and haloperidol.
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- 2011
6. Cardiovascular autonomic neuropathy in chronic kidney diseases
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L, Thapa, P, Karki, S K, Sharma, and B K, Bajaj
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Male ,Valsalva Maneuver ,Posture ,Blood Pressure ,Middle Aged ,Autonomic Nervous System Diseases ,Diabetic Neuropathies ,Cardiovascular Diseases ,Heart Rate ,Case-Control Studies ,Humans ,Kidney Failure, Chronic ,Diabetic Nephropathies ,Female ,Renal Insufficiency, Chronic ,Aged - Abstract
This study was conducted to explore cardiovascular autonomic neuropathy and its pattern in chronic kidney disease patients.Autonomic function using five standard tests was examined in 20 diabetic patients with CKD, 20 age and sex matched diabetic patients without CKD and 20 age and sex matched controls. Analysis of difference between the autonomic function was done in the three groups using Chi-square test or Fischer's test.Total 20 (100%) diabetic CKD patients were found to have autonomic neuropathy. Of these, 2 (10%) patients had early parasympathetic damage, 8 (40%) patients had definite parasympathetic damage, and 10 (50%) patients had combined damage. Heart rate response to standing was statistically significant (p = 0.014) among diabetic CKD patients when compared with diabetic patients without CKD. Combined form of autonomic dysfunction was more frequent in advanced stages of diabetic CKD. Three (42.85%) patients in stage 3 CKD, 4 (66.66%) patients in stage 4 CKD and 5 (71.42%) patients in stage 5 CKD, had combined autonomic failure.Autonomic neuropathy is common in native Nepalese diabetic CKD patients. Heart rate response to standing is significantly abnormal in diabetic CKD patients in comparison with diabetes mellitus patient without CKD. Severity of autonomic dysfunction increases with severity of CKD..
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- 2011
7. Cardiovascular Autonomic Neuropathyin Chronic Kidney Diseases
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P Karki, L Thapa, B K Bajaj, and SK Sharma
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lcsh:R5-920 ,medicine.medical_specialty ,business.industry ,Advanced stage ,General Medicine ,urologic and male genital diseases ,Age and sex ,medicine.disease ,female genital diseases and pregnancy complications ,Endocrinology ,Internal medicine ,Diabetes mellitus ,Chronic Kidney Diseases ,Medicine ,Stage (cooking) ,lcsh:Medicine (General) ,business ,Autonomic neuropathy ,Kidney disease ,Heart rate response - Abstract
INTRODUCTION: This study was conducted to explore cardiovascular autonomic neuropathy and its pattern in chronic kidney disease patients. METHODS: Autonomic function using five standard tests was examined in 20 diabetic patients with CKD, 20 age and sex matched diabetic patients without CKD and 20 age and sex matched controls. Analysis of difference between the autonomic function was done in the three groups using Chi-square test or Fischer's test. RESULTS: Total 20 (100%) diabetic CKD patients were found to have autonomic neuropathy. Of these, 2 (10%) patients had early parasympathetic damage, 8 (40%) patients had definite parasympathetic damage, and 10 (50%) patients had combined damage. Heart rate response to standing was statistically significant (p = 0.014) among diabetic CKD patients when compared with diabetic patients without CKD. Combined form of autonomicdysfunction was more frequent in advanced stages of diabetic CKD. Three (42.85%) patients in stage 3 CKD, 4 (66.66%) patients in stage 4 CKD and 5 (71.42%) patients in stage 5 CKD, had combined autonomic failure. CONCLUSIONS: Autonomic neuropathy is common in native Nepalese diabetic CKD patients. Heart rate response to standing is significantly abnormal in diabetic CKD patients in comparison with diabetes mellitus patient without CKD. Severity of autonomic dysfunction increases with severity of CKD.. KEYWORDS: cardiovascualr autonomic neuropathy, chronic kidney disease, diabetes mellitus.
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- 2010
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8. Paradoxical response in patients with CNS tuberculosis
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Meena, Gupta, B K, Bajaj, and Geeta, Khwaja
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Adult ,Male ,Adolescent ,Dose-Response Relationship, Drug ,Recurrence ,Antitubercular Agents ,Humans ,Female ,Treatment Failure ,Tuberculosis, Central Nervous System ,Drug Administration Schedule - Abstract
To report paradoxical response, i.e. recurrence of appearance of fresh symptoms, physical and radiological signs in a patient who had previously shown improvement with appropriate anti-tubercular medicines.Ten out of 58 patients of CNS tuberculosis, diagnosed on basis of clinical, laboratory and radiological data that initially showed clinical response to therapy only to deteriorate later were included in the study.Out of ten, three were males and seven were female with age range 13 to 28 years. The duration of time between initiation of therapy and worsening of patient was from one to seven months. Nine out of ten patients developed fresh intracranial tuberculoma while one case otherwise showing improvement developed expansion of tuberculoma and other one of empyema developed tuberculoma while on therapy. All these cases responded to addition of second line therapy or increase in dose of drugs previously prescribed and introduction or increased dose of steroid.Clinical judgement, regular follow up, guarded reassurance of patient is required to detect parodoxial response in CNS tuberculosis.
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- 2003
9. IgA monoclonal gammopathy of undetermined significance with peripheral neuropathy
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B K Bajaj, K. Sen, M Tatke, and Man Mohan Mehndiratta
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Male ,Sensorimotor peripheral neuropathy ,Pathology ,medicine.medical_specialty ,Neural Conduction ,Paraproteinemias ,immune system diseases ,hemic and lymphatic diseases ,Immunopathology ,medicine ,Reaction Time ,Humans ,cardiovascular diseases ,IgA Monoclonal Gammopathy ,Motor Neurons ,business.industry ,Peripheral Nervous System Diseases ,Middle Aged ,medicine.disease ,Benign Monoclonal Gammopathy ,Immunoglobulin A ,Monoclonal gammopathy ,Peripheral neuropathy ,Neurology ,Immunoglobulin M ,Myelin sheath ,Immunology ,Neurology (clinical) ,medicine.symptom ,business ,Monoclonal gammopathy of undetermined significance - Abstract
Monoclonal gammopathy of undetermined significance (MGUS) and peripheral neuropathy may be causally linked. In most cases, the M-protein is of IgG or IgM type. Peripheral neuropathy associated with IgA MGUS is uncommon, and there are limited reports. Here, we report a case of a 55-year-old male who was diagnosed to have symmetrical sensorimotor peripheral neuropathy associated with IgA MGUS with deposits of IgA-monoclonal protein in the myelin sheath.
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- 2002
10. Creutzfeldt-Jakob disease : report of 10 cases from North India
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M M, Mehndiratta, B K, Bajaj, M, Gupta, R, Anand, M, Tatke, S, Seryam, R, Nehru, V, Puri, and G A, Khwaja
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Adult ,Male ,Myoclonus ,Behavior ,Blindness, Cortical ,Cerebellar Ataxia ,Psychotic Disorders ,Humans ,Female ,Creutzfeldt-Jakob Syndrome ,Retrospective Studies - Abstract
Creutzfeldt-Jakob disease (CJD) is increasingly being reported over the last three decades as a result of heightened awareness of the disease. Various studies have reported annual incidence of 0.5-1.5 cases of CJD per million of general population. In India, the disease is still under reported. Over the period spanning from 1968-1997, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore recorded 69 cases of CJD from different parts of India in the CJD registry. This paper describes the clinical experience with cases of CJD managed at the Department of Neurology, G.B. Pant Hospital, New Delhi from 1990-1998. In this series, the mean age of the patients was 53.80 (+/- 7.32) years and there were 5 females and 5 males. Myoclonus was present in all the cases and abnormal behaviour with or without other features was the presenting complaint in 7 of the 10 patients, while one patient of CJD had cerebellar ataxia as the presenting feature. One patient with occipital variant of CJD presented with acute onset cortical blindness and myoclonic jerks. One of the patients had acute psychosis precipitated by emotional stress at the onset. Extrapyramidal features were noted in 7 of the 10 patients before death. The mean duration of symptoms from the onset of disease to death was 6.6 (+/- 6.11) months. Classical EEG changes were observed in all the patients, except in one possible case of occipital variant of CJD, where we did not have access to EEG record. Brain biopsy could be undertaken in 3 patients, and in 2 patients the features of subacute spongiform encephalopathy (SSE) were noted.
- Published
- 2002
11. METABOLISM OF OESTRADIOL-17β AND OESTRONE IN THE HUMAN UTERUS
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A. R. Krishnan, Kesho R. Laumas, V. Hingorani, and B. K. Bajaj
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Cytoplasm ,endocrine system ,medicine.medical_specialty ,Estrone ,Endocrinology, Diabetes and Metabolism ,Uterus ,Endometrium ,Endocrinology ,Microsomes ,Internal medicine ,Follicular phase ,polycyclic compounds ,medicine ,Humans ,skin and connective tissue diseases ,Receptor ,Cell Nucleus ,Estradiol ,urogenital system ,Chemistry ,Myometrium ,General Medicine ,Metabolism ,Menstruation ,Mitochondria ,medicine.anatomical_structure ,Female ,hormones, hormone substitutes, and hormone antagonists ,Subcellular Fractions ,Hormone - Abstract
A study of the metabolism of oestradiol in the human endometrium and myometrium of the proliferative and secretory phases of the cycle showed that the conversion of oestradiol to oestrone by endometrium in the proliferative phase was higher than that in the secretory phase. The decreased metabolic activity of the secretory phase endometrium was attributed to the influence of progesterone on the endometrium. The metabolic conversion of oestradiol to oestrone was enhanced when pyridine nucleotides were added to the system. The conversion of oestradiol to oestrone was maximum in the cytoplasmic and nuclear fractions of the endometrium. Furthermore, the conversion of oestradiol was low in all the subcellular fractions of the myometrium as compared with the endometrial subcellular fractions. The presence of co-factors increased the metabolic conversion of oestradiol to oestrone in the subcellular fractions of the endometrium. The presence of 17β-hydroxysteroid oxidoreductase was indicated in all the subcellular fractions. A correlation was found between the amount of oestradiol and oestrone bound to the receptors in the uterus and the rate of metabolism of oestradiol in the uterus. The physiological significance of metabolism of oestradiol and the hormone action are discussed.
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- 1975
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