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1. Comparison of Sodium Selenite and Selenium-Enriched Spirulina Supplementation Effects After Selenium Deficiency on Growth, Tissue Selenium Concentrations, Antioxidant Activities, and Selenoprotein Expression in Rats

Author

T. Castel, K. Léon, C. Gandubert, B. Gueguen, A. Amérand, A. Guernec, M. Théron, and K. Pichavant-Rafini

Subjects
Inorganic Chemistry, Selenium, Endocrinology, Diabetes and Metabolism, Biochemistry (medical), Clinical Biochemistry, Spirulina, Rat, Antioxidant activities, General Medicine, Selenoproteins, Biochemistry
Abstract

Selenium contributes to physiological functions through its incorporation into selenoproteins. It is involved in oxidative stress defense. A selenium deficiency results in the onset or aggravation of pathologies. Following a deficiency, the repletion of selenium leads to a selenoprotein expression hierarchy misunderstood. Moreover, spirulina, a microalga, exhibits antioxidant properties and can be enriched in selenium.. Our objective was to determine the effects of a sodium selenite or selenium-enriched spirulina supplementation. Thirty-two female Wistar rats were fed for 12 weeks with a selenium-deficient diet. After 8 weeks, rats were divided into 4 groups and were fed with water, sodium selenite (20 μg Se/kg body weight), spirulina (3 g/kg bw), or selenium-enriched spirulina (20 μg Se/kg bw + 3 g spirulina/kg bw). Another group of 8 rats was fed with normal diet during 12 weeks. Selenium concentration and antioxidant enzyme activities were measured in plasma, urine, liver, brain, kidney, heart, and soleus. Expression of GPx (1, 3), Sel (P, S, T, W), SEPHS2, TrxR1, ApoER2, and megalin were quantified in liver, kidney, brain, and heart. We showed that a selenium deficiency leads to a growth delay, reversed by selenium supplementation despite a minor loss of weight in week 12 for SS rats. All tissues displayed a decrease in selenium concentration following deficiency. The brain seemed protected. We demonstrated a hierarchy in selenium distribution and selenoprotein expression. A supplementation of sodium selenite improved GPx activities and selenoprotein expression while a selenium-enriched spirulina was more effective to restore selenium concentration especially in the liver, kidney, and soleus.

Published
2023

2. Réinsertion sociale après chirurgie de l’épilepsie

Author

B. Piel-Desruisseaux, F. Odier, and B. Gueguen

Subjects
medicine.medical_specialty, Rehabilitation, business.industry, medicine.medical_treatment, MEDLINE, Neuropsychology, medicine.disease, Surgery, Epilepsy, Multidisciplinary approach, medicine, Physical therapy, Epilepsy surgery, Neurology (clinical), Objective evaluation, business, Psychosocial
Abstract

No strict relationship has been observed between seizure outcome after surgery and the psychosocial status of patients with refractory epilepsy. The main reason is that seizures are not the sole criteria in evaluating social outcome. The presurgical status in terms of education, the mainly neuropsychological associated handicap, socio-occupational life, and the expectations of the patient must be taken into account. Psychosocial adjustment after surgery needs to be prepared long before surgery, in full cooperation with the patient and his or her family. Standardized tools must be developed to allow for a multidisciplinary approach and an objective evaluation of the psychosocial status of epileptic patients after surgery.

Published
2008
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3. Indications de l'EEG dans les confusions mentales et les troubles du comportement

Author

M.J. Guedj, B Gueguen, and P Raynaud

Subjects
medicine.medical_specialty, Clinical psychiatry, Modalities, medicine.diagnostic_test, Emergency unit, General Medicine, Disease, Electroencephalography, medicine.disease, Developmental psychology, Epilepsy, Neurology, Neuroimaging, Physiology (medical), medicine, Etiology, Neurology (clinical), Psychiatry, Psychology
Abstract

Even in 1998 at the time of brain imaging, EEG recording is undoubtedly useful in clinical psychiatry when a true cerebral disease takes the form of an acute psychiatric disorder. Though the real place of EEG recording cannot be yet accurately quantified, it may help guide the diagnosis, as it is of either positive (ie, confirming the diagnosis via additional information) or negative (ie, rejecting various etiologies) value. Most of the time, only the former is considered in published studies. The clinical value of EEG recording in psychiatry emergency unit is therefore still not clearly established. The study of patients admitted during two years in the emergency unit at Sainte-Anne hospital (Paris, France) does not bring new conclusions, mainly because of bias in the modalities of admission and follow-up. As well, the role of EEG recording for the diagnosis of non-psychiatric diseases in psychiatry emergency units cannot be defined today. The authors review clinical situations where EEG recording is still highly advisable.

Published
1998
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4. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain

Author

H. Hattig, C. Delli Pizzi, M. C. Addonizio, Michelle Davis, A. R. Giovagnoli, L. Florensa, M. Roth, J. de Kruijk, Francisco Lacruz, Ph. Dewailly, A. Toygar, C. Avendano, P.P. De Deyn, J. F. Hurtevent, F. Lomeila, T. W. Wong, Gordon T. Plant, M. Bud, H. J. Willison, DH Miller, D. W. Langdon, R. Cioni, J. Servan, A. Kaygisiz, E. Racadot, D. B. Schens, E. Picciola, L. Falip, C. Bouchard, J. Jotova, A. Jorge-Santamaria, P. Misra, A. Dufour, C. P. Panagopoulos, A. Venneri, B. Sredni, B. Angelard, M. Janelidze, M. Carreno, J. Obenberger, J. Pouget, H. W. Moser, R. Kaufmann, J. A. Molina, D. Linden, A. Martin Urda, E. Uvestad, A. Krone, J. P. Cochin, J. Mallecourt, A. Cambon-Thomsen, K. Violleau, P. Osschmann, A. M. Durocher, E. Bussaglia, D. M. Danielle, H. Efendi, C. Van Broeckhoven, K. G. Jordan, W. Rautenberg, C. Iniguez, J. M. Delgado, Graham Watson, M. Lawden, Gareth J. Barker, K. Stiasny, James T. Becker, G. Campanella, E. Peghi, A. Poli, A. Haddad, T. Yamawaki, Giacomo P. Comi, S. Sotgiu, B. Ersmark, A. Pomes, M. Ziegler, P. Ferrante, P. Ruppi, H. KuÇukoglu, R. Bouton, U. K. Rinne, P. Vieregge, M. Dary, P. Giunti, Peter J. Goadsby, S. Jung, E. Secor, A. Steinberg, N. Vila, M. A. Hernandez, M. Cursi, A. Enqelhardt, A. Engelhardt, J. Veitch, F. Di Silverio, F. Arnaud, B. Neundörfer, R. Brucher, Dominique Caparros-Lefebvre, B. Meyer, Marianne Dieterich, M. H. Snidaro, R. Gomez, R. Cerbo, M. Ragno, J. M. Vance, S. Nemni, A. Caliskan, F. Barros, I. Velcheva, D. Ceballos-Baumann, V. Barak, A. Avila, N. Antonova, F. Resche, S. Pappata, L. Varela, S. R. Silveira Santos, A. Cammarota, L. Naccache, Y. Nara, E. Tournier-Lasserves, R. Mobner, T. Chase, A. Ensenyat, J. Ulrich, G. Giegerich, M. Rother, M. Revilla, N. Nitschke, K. Honczarenko, E. Basart Tarrats, J. Blin, B. Jacob, J. Santamaria, S. Knezevic, J. L. Castillo, M. Antem, J. Colomer, O. Busse, Didier Hannequin, S. Carrier, J. B. Ruidavets, C. Rozman, J. Bogoussslavsky, J. Pascual Calvet, E. Monros, J. M. Polo, M. Zucconl, Javier Muruzabal, R. R. Allen, R. Rivolta, K. Haugaard, A. Nespolo, K. Hoang-Xuang, G. Bussone, T. Avramidis, E. Corsini, Christiana Franke, T. Vinogradova, H. Boot, K. Vestergaard, G. H. Jansen, N. Argentino, M. Raltzig, W. Linssen, Mark B. Pepys, P. Roblot, L. Lauritzen, E. Fainardi, D. Morin, T. X. Arbizu Urdiain, J. Wollenhaupt, S. Bostantjopoulou, G. Pavesi, A. D. Forman, Giovanni Fabbrini, D. Jean, J. J. Archelos, M. I. Blanchs, M. Del Gobbo, Anna Carla Turconi, Ch. Derouesné, Elio Scarpini, A. Visbeck, P. Castejon, J. P. Renou, F. Mounier-Vehier, G. Potagas, Ch. Duyckaerts, A. Filla, R. Schneider, G. Ronen, K. Nagata, J. P. Vedel, A. Henneberg, G. van Melle, C. Baratti, H. Knott, M. C. Prevett, A. Bes, B. Metin, Jos V. Reempts, L. Martorell, Mefkure Eraksoy, H. O. Handwerker, D. S. Younger, O. Oktem, D. Frongillo, C. Soriano-Soriano, L. Niehaus, F. Zipp, A. Tartaro, S Newman, R. H. Browne, P. Davous, R. Sanchez, M. Muros, M. E. Kornhuber, A. Lavarone, M. Mohr, M. R. Garcia, S. Russell, H. Kellar-Wood, M. R. Tola, B. Ostermeyer, Ch. Tzekov, K. Sartor, E. B. Ringelstein, P. P. Gazzaniga, Paul Krack, H. Fidaner, H. Rico, T. Dbaiss, F. Alameda, E. Torchiana, L. Rumbach, I. Charques, J. M. Bogaard, C. D. Frith, L. J. Rappelle, R. Brenner, A. Joutel, K. Fuxe, G. HÄcker, M. J. Blaser, J. Valls-SolÇ, G. Ulm, M. Alberdi, A. Bock, F. W. Bertelsmann, U. Wieshmann, J. Visa, J. R. Lupski, D. D'Amico, L. M. P. Ramos, A. A. Vanderbark, R. Horn, M. Warmuth, Dietmar Kühne, Mark S. Palmer, C. Ehrenheim, E. Canga, S. Viola, O. Scarpino, P. Naldi, R. Almeida, A. A. Raymond, J. Gamez, Stephan Arnold, A. DiGiovanni, J. Dalmau, C. C. Chari, H. F. Beer, J. C. Koetsier, J. Iriarte, E. Yunis, J. Casadevall, E. Le Guern, E. Stenager, S. R. Benbadis, J. M. Warter, F. Burklin, I. Theodorou, L. Johannesen, G. A. Graveland, X. Leclerc, I. Vecchio, L. Ozelius, G. Nicoletti, R. K. Gherardi, E. Esperet, M. L. Delodovici, F. Cattin, F. Paiau, Giorgio Sacilotto, C. A. J. Broere, D. Chavdarov, J. P. Willmer, C. H. Hawkes, Th. Naegele, E. Ellie, E. Dartigues, M. J. Guardiola, S. Hesse, Z. Levic, Marco Rovaris, P. Saugeir-Veber, B. A. Yaqub, H. F. Durwen, R. Larumbe, J. Ballabrina, M. Sendtner, J. Röther, M. Horstink, C. Kluglein, M.P. Montesi, H. Apaydin, J. Montoya, E. Waubant, Ch. Verellen-Dunoulin, A. Nicolai, J. Lopez-Delval, R. Lemon, G. Cantinho, E. Granieri, A. Zeviani, Wolfgang H. Oertel, U. Ficola, V. Di Piero, V. Fragola, K. Sabev, M. V. Guitera, I. Turki, F. Bolgert, P. Ingrand, J. M. Gobernado, L. M. E. Grimaldi, S. Baybas, B. Eymard, Y. Rolland, Y. Robitaille, Ta. Pampols, P. J. Koehler, A. Carroacedo, J. Vilchez, S. Di Vittorio, I. R. Rise, T. Nagy, M. Kuffner, E. Palazzini, A. Ott, J. Pruim, T. X. Arbizu, E. Manetti, C. Cervera, S. Felber, G. Gursoy, J. Scholz, G. A. Buscaino, M. S. Chen, A. Pascual, J. Hazan, J. U. Gajda, J. G. Cea, G. Bottini, G. Damalik, F. Le Doze, G. Bonaldi, J. M. Hew, C. Messina, A. M. Kennedy, J. M. Carney, N. M. F. Murray, M. Parent, M. Koepp, V. Dimova, D. De Leo, K. Jellinger, G. Salemi, S. Mientus, M. L. Hansen, F. Mazzucchelli, J. Vieth, M. Mauri, E. Bartels, L. Johannsen, C. Humphreys, J. Emile, D. N. Landon, E. Kansu, R. Sanchez-Pernaute, Rsj Frackowiak, M. Gonzalez Torres, L. Oller, C. Machedo, J. Kother, M. Billiard, H. Durak, T. Schindler, A. Frank, A. Uncini, A. Sbriccoli, C. Farinas, D. W. Paty, N. Fast, A. T. Zangaladze, A. Kerkhofs, J. M. Pino Garcia, I. De la Fuente, B. Marini, L. Gomez, I. Rubio, Alessandra Bardoni, C. Brodie, P. Acin, U. Sliwka, S. A. Hawkins, S. Tardieu, F. Vitullo, J. M. Pereira Monteino, R. Gagliardi, T. Jezewski, A. Cano, T. Lempert, F. Abad Alegria, G. Rotondo, D. Ince, C. Martinez Parra, Y. Huang, H. Luders, Y. Steinvil, F. G. A. Van Der Meche, R. Bianchi, A. Sanchez, T. Sevilla, J. M. Ketelslegers, A. Domzal-Stryga, M. Pandolfo, M. O. Josse, K. W. Neff, I. Blanco, G. W. Bruyn, O. W. Witte, J. L. Thibault, G. Andersen, J. Pariset, A. Marcone, R. J. M. Lane, A. Hofman, M. Verin, T. Matilla, P. Bedoucha, J. Roche, M. Lai, M. Collard, A. Ugarte, F. Gallecho, D. Silbersweig, C. Kennard, J. P. Azulay, T. W. Ho, P. L. I. Dellemijn, R. Girardello, F. Baas, B. Voss, F. Rozenberg, E. M. Brocker, V. Stanev, A. A. J. Soeterboek, A. Marra, A. Rey, E. Ertem, M. Sawradewicz-Rybak, J. De Keyser, P. Cavallari, F. Proust, Y. Chevalier, H. C. Hansen, D. Leys, C. A. Davie, K. Hoang-Xuan, C. Bairati, H. van Crevel, Thomas T. Warner, B. Bompais, A. Dobbeleir, T Campbell, C. Macko, C. J. M. Klijn, M. Dussallant, T. P. Berlit, W. Rozenbaum, M. J. van den Bent, W. A. Rocca, M. Muller, H. Hundemer, U. Zifko, M. Campera, F. Drislane, D. Ranoux, T. M. Kloss, Anil Kumar, I. Ruolt, C. Bargnani, B. Marescau, N. A. Losseff, S. Notermans, B. Kint, E. T. Burke, C. Aykut, J. Matias Guiu, P. Maquet, T. Drogendijk, M. Leone, K. von Ammon, M. Pepeliarska, C. Prados, L. DiGiamberardino, T. Logtenberg, G. Lenoir, I. Castaldo, Damhaut, M. Radionova, G. Sirabian, R. Navon, Giovanni Antonini, K. Al Moutaery, E. Chamas, R. Schönhuber, M. Giannini, B. Debilly, I. Labatut, H. Henon, J. A. Egido, M. Baudrimont, J. N. Lorenzo, J. E. C. Bromberg, R. Antonacci, J. J. Vilchez, T. Moulin, B. Rautenstrauss, Giovanni Meola, J. Noth, S Mammi, P. Laforet, F. Lopez, C. Gehring, S. Bort, G. Rancurel, D. Decamps, S. Kostadinova, Y. Shapira, B. Neundoerfer, D. Chavrot, M. Solimena, J. P. Salier, W. Deberdt, R. Hoff-Jörgensen, A. Messina, S. Meairs, G. Rosoklija, E. Nelis, I. Bertran, C. Ertekin, J. Lohmeyer, Mitermayer Galvao dos Reis, L. Calo, E. Maccagnano, A. P. Hays, J. Verlooy, M. G. Forno, T. Blanco, L. Bail, Gabriella Silvestri, J. Montero, F. Bertrand, R. T. Ghnassia, C. Besses, T. Sereghy, F. Shalit, G. Bogliun, S. Braghi, St. Baykouchev, C. Franke, A. Lasa, L. C. Archard, J. Kriebel, S. Shaunak, M. Nocito, Alexander Tsiskaridze, E. Manfredini, T. Seigal, David G. Gadian, M. Barlas, J. D. Degos, C. Seeber, J. Caemert, J. L. Mas, R. B. Pepinsky, M. G. D'Angelo, N. Baumann, S. Yorifuji, H. P. Endtz, M. A. Cassatella, R. A. C. Hughes, V. Golzi, A. Bittencourt, A. Ferreira, M. Sanson, C. Alper, M. Vermeulen, M. A. A. van Walderveen, E. Alexiou, C. H. Lucas, M. Fiorelli, Y. N. Debbink, R. Gil, S. Congia, T. Banerjee, J. M. Bouchard, A. N. Pinto, A. Ceballos-Baumann, G. Grollier, P. I. M. Schmitz, M. D. Catata, N. Lahat, N. S. Rao, P. Papathanasopoulos, J. Valls-Solé, D. Claus, G. Schroter, A. Castro, C. Videbaek, R. Martinez Dreke, A. D. Platts, M. Hermesl, A. C. PeÇanha-Martins, M. Cardoso Silva, P. Masnou, M. J. A. Tanner, Ch. Confavreux, B. Mishu, H. Rasmussen, L. Valenciano, Carlo Pozzilli, S. W. Li, V. Salzman, Y. Vashtang, Massimo Franceschi, M. Severo, G. Deuschl, S. Setien, G. Mariani, A. Protti, J. Castillo, M. J. B. Taphoorn, M. Frontali, I. Milonas, D. Decoq, J. A. Navarro, S. Castellvi-Pel, C. Ertikin, M. Urtasun, Y. Lajat, B. E. Kendall, E. Verdu, B. Gueguen, E. Boisen, R. Couderc, A Danek, JM Stevens, F. Nicoli, L. Feltri, M. L. Vazquez-Andre, J. A. Morgan-Hughes, L. D'Angelo, F. Y. Liew, L. F. Pascual, J. Patrignani Ochoa, Vittorio Martinelli, J. Cophignon, L. Zhang, S. Martin, J. F. Meder, H. C. Buschmann, L. Bertin, J. van Gijn, A. Barreiro, A. Cools, C. Leon, A. Berod, E. A. Anllo, E. Zanette, L. Petrov, R. Barona, B. Gallicchio, P. J. Cozzone, N. Diederich, G. Cancel, L. Schelosky, P. Orizaola, K. Yulug, S. Ozer, Valeria A. Sansone, B. Guiraud-Chaumeil, K. Voigt, P. Labauge, M. Eoli, J. Zhu, J. Aguirre, M. Ferrarini, B. Zyluk, E. Planas, A. Cadilha, C. Tortorella, H. Bismuth, C. E. Counsell, A. Laun, A. Ferlini, Rio J. Montalban, N. Biary, L. Becker, M. Fardeau, M. Poloni, V. M. S. de Bruin, C. Fornada, J. Barros, E. Ganzmann, E. Touze, D. Wallach, J. Peila, H. Fujimura, M. T. Iba-Zizen, G. Macchi, C. Villoslada, R. Gouider, Ph. Rondepierre, P. Grummich, P. Chiodi, C. Conte, M. Michels, P. Annunziata, G. Semana, C. Sommer, J. Vajsar, D. Zekin, J. Kulisevsky, David G. Munoz, B. Jacotot, M. Magoni, A. Luxen, T. Garcia-Silva, S. Di Cesare, Christophe Tzourio, M. Gomori, I. Picomell, L. Santoro, F. Villa, Giovanni Pennisi, T. Ribalta, J. M. Molto, L. Marzorati, P. Loiseau, F. Gemignani, A. Gironell, J. Wissel, A. Prusinski, F. Cailloux, P. Villanueva-Hemandez, P. Cozzone, T. Del Ser, J. Sans-Sabrafen, M. Zappia, P. W. A. Willems, G. Tchernia, D. Gardeur, R. Bauer, F. Palomo, H. Metz, S. Lamoureux, C. Chastang, I. Reinhard, A. Goldfarb, S. Harder, Jordi Río, C. Ozkara, E. Tekinsoy, P. Vontobell, J. De Recondo, M. Rabasa, L. Lacomblez, F. Boon, Dgt Thomas, V. Palma, Renato Mantegazza, A. Dervis, M. Nueckel, B. YalÇinerner, I. Duran, G. Dalla Volta, A. Zubimendi, J. Pinheiro, A. Marbini, Xavier Montalban, H. Wekerle, X. Pereira Monteino, F. Crespo, F. Koskas, N. Battistini, C. Ruiz, H. Offner, J. de Pommery, P. Kanovsky, J. Y. Barnett, J. Pardo, G. Tomei, R. Rene, H. M. Lokhorst, P. Thajeb, H. Bilgin, D. McGehee, R. Fahsold, L. Morgante, Katie Sidle, C. Delwaide, M. N. Diaye, P. H. Rice, A. Creange, C. Sabev, K. Stephan, K. WeilBenborn, G. Magnani, L. Grymonprez, F. Cardellach, M. Kaps, N. G. Meco, F. Vega, V. Bonifati, A. Desomer, M. Baldy-Moulinier, G. Kvale, F. J. Authier, B. Yegen, T. Ho, J. M. Rozet, E. A. Cabanis, L. Bruce, L. Ambrosoli, M. A. Petrella, M. Hernandez, P. Timmings, H. B. van der Worp, F. Mahieux, A. Urbano-Marquez, D. A. Krendel, A. A. Garcia, R. Divari, R. Michalowicz, M. R. Piedmonte, M. Bondavalli, M. Zanca, P. F. Ippel, Onofre Combarros, B. Tavitian, E. Hirsch, I. Anastasopoulos, A. Roses, A. Köhler, P. Vienna, V. Timmerman, P. Sergi, F. Cornelio, A. Di Pasquale, R. Verleger, S. Castellvirel, J. Proano, B. van Moll, F. Rubio, W. Hacke, I. Lavenu, L. Zetta, M. W. Tas, N. Bittmann, M. Bonamini, O. R. Hommes, V. Dousset, N. Afsar, S. Belal, R. R. Myers, J. Goes, Giuseppe Vita, E. Clementi, V. G. Karepov, M. Jueptner, A Vincent, P. Emmrich, Th. Heb, A. Caballo, J. Gallego, T. Mokrusch, C. Perla, L. Gebuhrer, O. Titlbach, Alessandro Prelle, A. Czlonkowska, M. Russo, D. Hadjiev, T. S. Chkhikvishvili, M. Oehlschlager, G. Becker, I. Günther, E. N. Stenager, J. Garcia Agundez, J. Casademont, J. Batlle, S. Podobnik-Sarkanji, C. Alonso-Villaverde, B. Delaguillaume, B. Genc, B. Mazoyer, A. Rodriguez-Al-barino, Ch. Hilger, B. Ferrero, R. Price, W. Grisold, L. Fuhry, D. Oulbani, D. Ewing, A. Petkov, W. Walther, A. Gokyigit, John Newsom-Davis, J. Tayot, D. Seliak, G. Pelliccioni, D. Campagne, K. Kessler, F. Boureau, D. Perani, J. P. N'Guyen, N. Tchalucova, B. A. Antin-Ozerkis, C. Lacroix, B. D. Aronovich, I. H. Jenkins, E. A. dos Reis, M. Hortells, H. M. Meinck, H. Ch. Buschmann, S. C. J. M. Jacobs, T. Wetter, P. Creissard, N. Martinez, J. Weidenfeldl, H. J. Sturenburg, G. Damlacik, V. Gracia, J. C. Turpin, A. Pou-Serradell, J. P. Vincent, T. Gagoshidze, U. Ozkutlu, M. McLeod, K. Siegfried, I. Tchaoussoglou, J. Hildebrand, S. Kowalska, M. C. Picot, G. Galardin, L. Crevits, F. Andreetta, S. Larumbe-Lobalde, G. de la Sierra, J. C. Alvarez-Cermeno, R. J. Seitz, P. L. Oey, L. Ptacek, A. M. J. Paans, A. Wirrwar, A. Schmied, J. Uilchez, H. Tounsi, D. Hipola, V. Avoledo, Y. Hirata, P. Vermersch, T. M. Aisonobe, J. Valls-SoIè, H. Staunton, J. Dichgans, R. Karabudak, I. Dones, G. Porta, E. Janssens, Maria Martinez, J. M. Fernandez-Real, R. Villagra, Y. Yoshino, C. Kabus, K. Schimrigk, I. Girard-Buttaz, F. Piccoli, F. Aichner, P. Zuchegna, S. M. Al Deeb, F. Bono, N. Busquets, A. Jobert, Patrizia Ciscato, M. Martin, L. Polman, S. Darbra, V. Le Cam-Duchez, F. Baldissera, B. Baykan-Kurt, D. Guez, M. Bratoeva, H. Matsui, M. Mila, H. Perron, L. Bjorge, G. Husby, Steven T. DeKosky, D. R. Cornblath, J. M. Gabriel, J. J. Poza, Y. Wu, A. Toscano, R. P. Kleyweg, J. Kuhnen, S. O. Confort-Gouny, A. Barcelo, A. M. Conti, C. Fiol, C. Steichen-Wiehn, J. Rodes, M. Cavenaile, C. Vedeler, M. Drlicek, C. Argentino, M. L. Peris, A. Cervello, A. Z. GinaÏ, S. Yancheva, D. Passingham, S. Aoba, D. L. 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Henderson, R. Massa, A. Cruz Martinez, U. Liska, F. Hecht, Ernst Holler, V. S. de Bruin, B. B. Sheitman, S. M. Bentzen, C. Bayindir, F. Pallesta, P. E. Roland, J. Parrilla, P. Zunker, L. F. Burchinskaya, G. Mellino, S. Ben Ayed, D. Bonneau, P. Nowacki, M. Goncalves, P. Riederer, N. Mavroudakis, J. Togores, L. Rozewicz, S. Robeck, Y. Perez Gilabert, L. Rampello, A. Rogopoulos, S. Martinez, F. Schildermans, C. Radder, P. B. Hedlund, J. Cambier, M. Aabed, G. D. Jackson, P. Gasparini, P. Santacruz, J. Vandevivere, H. Dural, A. Mantel, W. Dorndorf, N. Ediboglu, A. Lofgren, J. Bogousslavsky, P. Thierauf, L. Goullard, R. Maserati, B. Moering, M. Ryba, J. Serra, G. G. Govan, A. Pascual-Leone, S. Schaeffer, M. R. Rosenfeld, A. P. Correia, K. Ray Chaudhuri, L. Campbell, R. Spreafico, B. Genetet, A. M. Tantot, R. A. G. Hughes, J. A. Vidal, G. Erkol, J. Y. Delattre, B. Yaqub, B. K. Hecht, E. Mayayo, Ph. Scheltens, J. Corral, M. Calaf, L. Henderson, C. Y. Li, U. Bogdahn, R. Sanchez-Roy, M. 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Brasic, W. Heide, I. Santilli, W. M. Korn, D. Selcuki, M. J. Barrett, D. Krieger, T. Leon, T. Houallah, M. Tournilhac, C. Nos, D. Chavot, F. Barbieri, F. J. Jimenez-Jimenez, J. Muruzabal, K. Poeck, A. Sennlaub, L. M. Iriarte, L. G. Lazzarino, C. Sanz, P. A. Fischer, S. D. Shorvon, R. Hoermann, F. Delecluse, M. Krams, O. Corabianu, F. H. Hochberg, Christopher J. Mathias, B. Debachy, C. M. Poser, L. Delodovici, A. Jimenez-Escrig, F. Baruzzi, F. Godenberg, D. Cucinotta, P. J. Garcia Ruiz, K. Maier-Hauff, P. R. Bar, R. Mezt, R. Jochens, S. Karakaneva, C. Roberti, E. Caballero, Joseph E. Parisi, M. Zamboni, T. Lacasa, B. Baklan, J. C. Gautier, J. A. Martinez-Matos, W. Pollmann, G. Thomas, L. Verze, E. Chleide, R. Alvarez Sala, I. Noel, E. Albuisson, O. Kastrup, S. I. Rapoport, H. J. Braune, H. Lörler, M. Le Merrer, A. Biraben, S. Soler, S. J. Taagholt, U. Meyding-Lamadé, K. Bleasdale-Barr, Isabella Moroni, Y. Campos, J. Matias-Guiu, G. Edan, M. G. Bousser, John B. Clark, J. Garcia de Yebenes, N. K. Olsen, P. Hitzenberger, S. Einius, Aj Thompson, Ch. J. Vecht, T. Crepin-Leblond, Klaus L. Leenders, A. Di Muzio, L. Georgieva, René Spiegel, K. Sabey, D. Ménégalli, J. Meulstee, U. Liszka, P. Giral, C. Sunol, J. M. Espadaler, A. D. Crockar, K. Varli, G. Giraud, P. J. Hülser, A. Benazzouz, A. Reggio, M. Salvatore, K. Genc, M. Kushnir, S. Barbieri, J. Ph. Azulay, M. Gianelli, N. Bathien, A. AlMemar, F. Hentati, I. Ragueneau, F. Chiarotti, R. C. F. Smits, A. K. Asbury, F. Lacruz, B. Muller, Alan J. Thompson, Gordon Smith, K. Schmidt, C. Daems Monpeun, Juergen Weber, A. Arboix, G. R. Fink, A. M. Cobo, M. Ait Kaci Ahmed, E. Gencheva, Israel-Biet, G. Schlaug, P. De Jonghe, Philip Scheltens, K. Toyka, P. Gonzalez-Porque, A. Cila, J. M. Fernandez, P. Augustin, J. Siclia, S. Medaglini, D. E. Ziogas, A. Feve, L. Kater, G. J. E. Rinkel, D. Leppert, Rüdiger J. Seitz, S. Ried, C. Turc-Carel, G. Smeyers, F. Godinho, M. Czygan, M. Rijntjes, E. Aversa, M. Frigo, Leif Østergaard, J. L. Munoz Blanco, A. Cruz-Matinez, J. De Reuck, C. Theillet, T. Barroso, V. Oikonen, Florence Lebert, M. Kilinc, C. Cordon-Cardon, G. Stoll, E. Thiery, F. Pulcinelli, J. Solski, M. Schmiegelow, L. J. Polman, P. Fernandez-Calle, C. Wikkelso, M. Ben Hamida, M. Laska, E. Kott, W. Sulkowski, C. Lucas, N. M. Bornstein, D. Schmitz, M. W. Lammers, A. de Louw, R. J. S. Wise, P. A. van Darn, C. Antozzi, P. Villanueva, P. H. E. Hilkens, C. Constantin, W. Ricart, A. Wolf, M. Gamba, P. Maguire, Alessandro Padovani, B. M. Patten, Marie Sarazin, H. Ackermann, L. Durelli, S. Timsit, Sebastian Jander, B. W. Scheithauer, G. Demir, J. P. Neau, P. Barbanti, A. Brand, N. AraÇ, V. Fischer-Gagnepain, R. Marchioli, G. Serratrice, C. Maugard-Louboutin, G. T. Spencer, D. Lücke, G. Mainardi, K. Harmant Van Rijckevorsel, G. B. Creel, R. Manzanares, Francesco Fortunato, A. May, J. Workman, K. Johkura, E. Fernandez, Carlo Colosimo, L. Calliauw, L. Bet, Félix F. Cruz-Sánchez, M. Dhib, H. Meinardi, F. Carrara, J. Kuehnen, C. Peiro, H. Lassmann, K. Skovgaard Olsen, A. McDonald, L. Sciulli, A. Cobo, A. Monticelli, B. Conrad, J. Bagunya, J. Benitez, V. Desnizza, B. Dupont, O. Delrieu, D. Moraes, J. J. Heimans, F. Garcia Rio, M. Matsumto, A. Fernandez, R. Nermni, R. Chalmers, M. J. Marchau, F. Aguado, P. Velupillai, P. J. Martin, P. Tassan, V. Demarin, A. Engelien, T. Gerriets, Comar, J. L. Carrasco, J. P. Pruvo, A. Lopez de Munain, D. Pavitt, J. Alarcon, Chris H. Polman, B. Guldin, N. Yeni, Hartmut Brückmann, N. Wilczak, H. Szwed, R. Causaran, G. Kyriazis, M. E. Westarp, M. Gasparini, N. Pecora, J. M. Roda, E. Lang, V. Scaioli, David R. Fish, D. Caputo, O. Gratzl, R. Mercelis, A. Perretti, G. Steimetz, I. Link, C. Rigoletto, A. Catafau, G. Lucotte, M. Buti, G. Fagiolari, A. Piqueras, C. Godinot, J. C. Meurice, Erodriguez J. Dominigo, F. Lionnet, H. Grzelec, David J. Brooks, P. M. G. Munro, F. X. Weilbach, M. Maiwald, W. Split, B. Widjaja-Cramer, V. Ozturk, J. Colas, E. Brizioli, J. Calleja, L. Publio, M. Desi, R. Soffietti, P. Cortinovis-Tourniaire, E. F. Gonano, G. Cavaletti, S. Uselli, K. Westerlind, H. Betuel, C. O. Dhiver, H. Guggenheim, M. Hamon, R. Fazio, P. Lehikoinen, A. Esser, B. Sadzot, G. Fink, Angelo Antonini, D. Bendahan, V. Di Carlo, G. Galardi, A. F. Boller, M. Aksenova, Del Fiore, V. de la Sayette, H. Chabriat, A. Nicoletti, A. Dilouya, M. L. Harpin, E. Rouillet, J. Stam, A. Wolters, M. R. Delgado, Eduardo Tolosa, G. Said, A. J. Lees, L. Rinaldi, A. Schulze-Bonhage, MA Ron, C. Lefebvre, E. W. Radü, R. Alvarez, M. L. Bots, P. Reganati, S. Palazzi, A. Poggi, N. J. Scolding, V. Sazdovitch, T. Moreau, E. Maes, M. A. Estelies, P. Petkova, Jose-Felix Marti-Masso, G De La Meilleure, N. Mullatti, M. Rodegher, N. C. Notermans, T. A. T. Warner, S. Aktan, J. P. Louboutin, L. Volpe, C. Scheidt, W. Aust, C. M. Wiles, U. Schneider, S. K. Braekken, W. R. Willems, K. Usuku, Peter M. Rothwell, C. Talamon, M. L. Sacchetti, A. Codina, M. H. Marion, A. Santoro, J. Roda, A. Bordoni, D. J. Taylor, S. Ertas, H. H. Emmen, J. Vichez, V. BesanÇon, R. E. Passingham, M. L. Malosio, A. Vérier, M. Bamberg, A. W. Hansen, E. Mostacero, G. Gaudriault, Marie Vidailhet, B. Birebent, K. Strijckmans, F. Giannini, T. Kammer, I. Araujo, J. Nowicki, E. Nikolov, A. Hutzelmann, R. Gherardi, J. Verroust, L. Austoni, A. Scheller, A. Vazquez, S. Matheron, H. Holthausen, J. M. Gerard, M. Bataillard, S. Dethy, V. H. Patterson, V. Ivanez, N. P. Hirsch, F. Ozer, M. Sutter, C. Jacomet, M. Mora, Bruno Colombo, A. Sarropoulos, T. H. Papapetropoulos, M. Schwarz, D. S. Dinner, N. Acarin, B. Iandolo, J. O. Riis, P. R. J. Barnes, F. Taroni, J. Kazenwadel, L. Torre, A. Lugaresi, I. L. Henriques, S. Pauli, S. Alfonso, Pedro Quesada, A. S. T. Planting, J. M. Castilla, Thomas Gasser, M. Van der Linden, A. Alfaro, E. Nobile-Orazio, G. Popova, W. Vaalburg, F. G. A. van der Mech, L. Williams, F. Medina, J. P. Vernant, J. Yaouanq, B. Storch-Hagenlocher, A. Potemkowski, R. Riva, M. H. Mahagne, M. Ozturk, Ve. Drory, N. Konic, C. Jungreis, A. Pou Serradell, J. L. Gauvrit, G. J. Chelune, S. Hermandez, T. Dingus, L. Hewer, Ch. Koch, M. N. Metz-Lutz, G. Parlato, M. Sinaki, Charles Pierrot-Deseilligny, H. C. Diener, J. Broeckx, J. Weill-Fulazza, M. L. Villar, M. Rizzo, O. Ganslandt, C. Duran, N. A. Fletcher, G. Di Giovacchino, Susan T. Iannaccone, C. Kolig, N. Fabre, H. A. Crockard, Rita Bella, M. Tazir, E. Papagiannuli, K. Overgaard, Emma Ciafaloni, I. Lorenzetti, F. Viader, P. A. H. Millac, I. Montiel, L. H. Visser, M. Palomar, P. L. Murgia, H. Pedersen, Rafael Blesa, S. Seddigh, W. O. Renier, I. Lemahieu, H. M. L. Jansen, L. Rosin, J. Galofre, K. Mattos, M. Pondal, G. M. Hadjigeorgiou, D. Francis, L. Cantin, D. Stegeman, M. Rango, A. B. M. F. Karim, S. Schraff, B. Castellotti, I. Iriarte, E. Laborde, T. J. Tjan, R. Mutani, D. Toni, B. Bergaasco, J. G. Young, C. Klotzsch, A. Zincone, X. Ducrocq, M. Uchuya, O. J. Kolar, A. Quattrone, T. Bauermann, Nereo Bresolin, J. Vallée, B. C. Jacobs, A. Campos, Werner Poewe, J. A. Villanueva, A. W. Kornhuber, A. Malafosse, E. Diez-Tejedor, G. Jungreia, M. J. A. Puchner, A. Komiyama, O. Saribas, V. Volpini, L. Geremia, S. Bressi, A. Nibbio, Timothy E. Bates, T. z. Tzonev, E. Ideman, G. A. Damlacik, G. Martino, G. Crepaldi, T. Martino, Kjell Någren, E. Idiman, D. Samuel, J. M. Perez Trullen, Y. van der Graaf, J. O. Thorell, M. J. M. Dupuis, E. Sieber, R. D'Alessandro, C. Cazzaniga, J. Faiss, A. Tanguy, A. Schick, I. Hoksergen, A. Cardozo, R. Shakarishvili, G. K. Wennlng, J. L. Marti-Vilalta, J. Weissenbach, I. L. Simone, Amalia C. Bruni, Darius J. Adams, C. Weiller, A. Pietrangeli, F. Croria, C. Vigo-Pelfrey, Patricia Limousin, A. Ducros, G. Conti, O. Lindvall, E. Richter, M. Zuffi, A. Nappo, T. Riise, J. Wijdenes, M. J. Fernandez, J. Rosell, P. Vermersh, S. Servidei, M. S. C. Verdugo, F. Gouttiere, W. Solbach, M. Malbezin, I. S. Watanabe, A. Tumac, W. I. McDonald, D. A. Butterfield, P. P. Costa, F. deRino, F. Bamonti, J. M. Cesar, C. H. Lahoz, I. Mosely, M. Starck, M. H. Lemaitre, K. M. Stephan, S. Tex, R. Bokonjic, I. Mollee, L. Pastena, M. Gutierrez, F. Boiler, M. C. Martinez-Para, M. Velicogna, O. Obuz, A. Grinspan, M. Guarino, L. M. Cartier, E. Ruiz, D. Gambi, S. Messina, M. Villa, Michael G. Hanna, J. Valk, Leone Pascual, M. Clanet, Z. Argov, B. Ryniewicz, E. Magni, B. Berlanga, K. S. Wong, C. Gellera, C. Prevost, F. Gonzalez-Huix, R. Petraroli, J. E. G. Benedikz, I. Kojder, C. Bommelaer, L. Perusse, M. R. Bangioanni, Guy M. McKhann, A. Molina, C. Fresquet, E. Sindern, Florence Pasquier, M. J. Rosas, M. Altieri, O. Simoncini, M. Koutroumanidis, C. A. F. Tulleken, M. Dary-Auriol, S. Oueslati, H. Kruyer, I. Nishisho, C. R. Horning, A. Vital, G. V. Czettritz, J. Ph. Neau, B. Mihout, A. Ameri, M. Francis, S. Quasthoff, D. Taussig, S. Blunt, P. Valentin, C. Y. Gao, O. Heinzlef, H. d'Allens, C. Coudero, M. Erfas, G. Borghero, P. J. Modrego Pardo, M. C. Patrosso, N. L. Gershfeld, P. A. J. M. Boon, O. Sabouraud, M. Lara, J. Svennevig, G. L. Lenzi, A. Barrio, H. Villaroya, JosÇ M. Manubens, O. Boespflug-Tanguy, M. Carreras, D. A. Costiga, J. P. Breux, S. Lynn, C. Oliveras Ley, A. G. Herbaut, J. Nos, C. Tornali, Y. A. Hekster, J. L. Chopard, J. M. Manubens, P. Chemouilli, A. Jovicic, F. Dworzak, S. Smirne, S. E. Soudain, B. Gallano, D. Lubach, G. Masullo, G. Izquierdo, A. Pascual Leone Pascual, A. Sessa, V. Freitas, O. Crambes, L. Ouss, G. W. Van Dijk, P. Marchettini, P. Confalonieri, M. Donaghy, A. Munnich, M. Corbo, and M. E. L. van der Burg

Subjects
Neurology, business.industry, Media studies, Library science, Medicine, Neurology (clinical), business
Published
1994
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5. Apport de l'EEG quantifié au diagnostic de démence de type Alzheimer

Author

B. Gueguen, H Hossard, C Derouesné, M Mann, J Gaches, S. Guillou, D. Ancri, E Landre, and M.C. Bourdel

Subjects
Neurology, Physiology (medical), Neurology (clinical), General Medicine, Psychology, Humanities, Computerized eeg
Abstract

Resume Soixante dix-neuf sujets d'âge moyen 70,2 ans (31 hommes et 48 femmes) atteints de demence de type Alzheimer probable au stade de debut de la maladie et 17 sujets temoins d'âge moyen 72,2 ans (cinq hommes et 12 femmes) ont ete etudies en EEG quantifie avec analyse topographique et en EEG standard (lecture visuelle du trace analogique). Les resultats montrent que des parametres EEG simples tels que la frequence moyenne dominante (FM) dans la bande 3,5–13 Hz et le rapport alpha/theta permettent de discriminer des sujets normaux de patients DTA avec une sensibilite superieure a l'EEG classique. Les valeurs de 8,6 pour la FM et de 1,3 pour le rapport alpha/theta sont proposees comme frontieres entre normal et pathologique. L'analyse de la repartition topographique des anomalies n'apporte, par contre, aucun argument utile supplementaire a la discrimination des deux groupes.

Published
1991
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6. Analyse topographique des potentiels évoqués endogènes chez des sujets âgés déprimés et chez des sujets atteints de démence de type Alzheimer

Author

H. Loo, B Samuel-Lajeunesse, B. Gueguen, S. Guillou, M.F. Poirier, M.H. de Brionne, C Derouesné, M.C. Bourdel, and G Loas

Subjects
Gynecology, medicine.medical_specialty, Neurology, Physiology (medical), medicine, Neurology (clinical), General Medicine, Psychology
Abstract

Resume Les latences, les amplitudes et la localisation des maxima des pics des reponses evoquees auditives tardives ont ete etudiees dans trois groupes de sujets âges: normaux, deprimes et dements de type Alzheimer (DTA) probable. Les reponses evoquees par un paradigme oddball simple ont ete recueillies avec 16 electrodes disposees d'apres le SI 10–20 au cours de deux situations experimentales: comptage des stimulations rares et reponse motrice avec mesure du temps de reaction (TR). Aucune difference n'est observee entre les trois groupes en ce qui concerne les amplitudes. Une difference significative est observee pour les latences de P3 en comptage mental entre les groupes DTA et deprimes mais pas entre DTA et temoins ou temoins et deprimes. Cette difference n'atteint pas le seuil de significativite pour la reponse motrice. Le maximum d'amplitude du pic P3 se situe sur les regions anterieures chez la plupart des sujets dements alors qu'il a un maximum posterieur chez les sujets deprimes et chez les temoins. Ainsi, l'etude de la repartition topographique de la reponse P3 pourrait permettre de caracteriser, au stade precoce, certaines DTA alors que les amplitudes et les latences sont encore dans les limites de la normale.

Published
1991
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7. Intérêt de l'EEG pour la prédiction de l'évolution des démences de type Alzheimer

Author

C Derouesné, A Rahal, B. Gueguen, J. Gasnault, M.C. Bourdel, D. Ancri, E Landre, and S. Guillou

Subjects
Neurology, Physiology (medical), Philosophy, Neurology (clinical), General Medicine, Humanities, Computerized eeg
Abstract

Resume Vingt patients atteints de demence de type Alzheimer probable ont ete examine sur le plan neuropsychologique et EEG a deux temps differents separes par un intervalle moyen de 14,5 mois. Au terme de cette periode, les sujets qui se sont aggraves sur le plan neuropsychologique (n = 8) ont ete separes des sujets qui sont restes stables (n = 12). Lorsque l'on regarde les caracteristiques EEG au ler examen (T1), mais aussi apres le suivi evolutif au 2e examen (T2) ou lorsque l'on regarde la difference T1–T2 aucune difference significative n'apparait entre les deux groupes, tant a la periode initiale qu'au terme de la periode de suivi. On ne peut cependant conclure que l'EEG n'a pas d'interet dans l'appreciation de l'evolutivite des demences car les sujets qui restent stables sur le plan cognitif et sur le plan EEG ont, en general dans notre etude, une frequence moyenne qui reste stable. La stabilite de la frequence moyenne pourrait donc constituer un parametre interessant pour l'appreciation du potentiel evolutif des demences mais cela doit etre teste sur une population plus importante de sujets et comportant notamment, parmi les aggraves, plus de sujets passant du stade modere au stade severe.

Published
1991
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8. Comparaison des aspects SPECT et EEG quantifié dans les démences de type Alzheimer

Author

C Derouesné, S. Guillou, D. Ancri, E Landre, M.C. Bourdel, and B. Gueguen

Subjects
Neurology, Physiology (medical), Philosophy, Neurology (clinical), General Medicine, Humanities, Computerized eeg
Abstract

Resume Quarante et un sujets atteints de demence de type Alzheimer (DTA) probable ont ete etudies en EEG quantifie (Q-EEG) et en emission monophotonique a l'isopropyl-iodoamphetamine (SPECT-IMP). Quatre groupes sont distingues selon la topographie de l'hypoperfusion SPECT : frontal, temporo-parietal, fronto-parietal et fronto-temporo-parietal. L'analyse Q-EEG montre que les deux derniers groupes ont des alterations EEG nettement plus marquees que les deux premiers. Des parametres Q-EEG dans les limites de la normale pourraient etre en faveur du diagnostic de DTA avec atteinte frontale ou temporoparietale dominante. Mais des biais lies a la duree d'evolution ou au degre d'evolutivite ne peuvent etre exclus. Quoi qu'il en soit les modifications de l'EEG sont diffuses et ne refletent pas la topographie de l'hyperfusion SPECT. Cela remet en question l'interet de l'analyse de la topographie des anomalies de l'EEG dans les DTA et souleve le probleme de la signification des alterations regionales de perfusion observees en SPECT.

Published
1991
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9. [Social rehabilitation after epilepsy surgery]

Author

B, Gueguen, B, Piel-Desruisseaux, and F, Odier

Subjects
Adult, Male, Epilepsy, Treatment Outcome, Socioeconomic Factors, Humans, Electroencephalography, Female, Postoperative Period, Social Adjustment, Neurosurgical Procedures
Abstract

No strict relationship has been observed between seizure outcome after surgery and the psychosocial status of patients with refractory epilepsy. The main reason is that seizures are not the sole criteria in evaluating social outcome. The presurgical status in terms of education, the mainly neuropsychological associated handicap, socio-occupational life, and the expectations of the patient must be taken into account. Psychosocial adjustment after surgery needs to be prepared long before surgery, in full cooperation with the patient and his or her family. Standardized tools must be developed to allow for a multidisciplinary approach and an objective evaluation of the psychosocial status of epileptic patients after surgery.

Published
2008

10. P 147. Impaired modulation of intracortical inhibition during Go–Stop task in schizophrenia

Author

Marie-Odile Krebs, B. Gueguen, Benoît Crépon, Påvel G. Lindberg, Raphaël Gaillard, Isabelle Amado, and Agathe Saby

Subjects
medicine.medical_specialty, medicine.medical_treatment, Index finger, Stop signal, Audiology, behavioral disciplines and activities, Sensory Systems, Transcranial magnetic stimulation, medicine.anatomical_structure, Neurology, Physiology (medical), Healthy volunteers, medicine, Intracortical inhibition, Silent period, Neurology (clinical), Cortical inhibition, Primary motor cortex, Psychology, Neuroscience
Abstract

Background Impaired inhibition has been reported in patients with schizophrenia in a variety of cognitive and motor tasks. Recent transcranial magnetic stimulation studies performed during rest show reduced cortical inhibition in primary motor cortex (M1) at rest in schizophrenia patients, supporting the hypothesis of impaired GABA-ergic inhibition as an underlying mechanism. However, cortical excitability and intracortical inhibition in M1 are highly task-dependent, for example, inhibiting a planned motor response leads to reduced excitability and enhanced intracortical inhibition. Studies on task-dependent cortical excitability and inhibition are lacking in schizophrenia. The aim of this study was therefore to investigate cortical excitability and intracortical inhibition during voluntary motor inhibition in patients with schizophrenia. Methods 25 stabilized patients with schizophrenia (DSMIV) and a group of 23 age-comparable healthy volunteers were included. We used a modified version of the Go–Stop task to study voluntary motor inhibition. This task consisted of moving the index finger in response to Go and Stop signals. In 30% of trials the subject received a visual cue to inhibit the prepared finger lift. Paired-pulse transcranial magnetic stimulation (TMS) was used to measure M1 excitability and short-latency intracortical inhibition (SICI%) during three phases of the task: (i) early without movement preparation (Early); (ii) late with preparation of finger lift (Late prep ); and (iii) late with inhibition of finger lift (Late inhib ). Motor evoked potentials (MEPs) were recorded from the first dorsal interosseous muscle. Results Patients and control subjects performed equally on the voluntary inhibition task, with similar stop signal reaction times (mean SSRT controls 189 ± 21 ms and patients 186 ± 31 ms, P = 0.6). TMS at rest revealed similar resting and active motor thresholds in patients and controls (P > 0.9). The cortical silent period was shorter in the patients but did not differ significantly (mean controls 162 ± 30 ms and patients 147 ± 61 ms, P = 0.36). During the Go–Stop task, cortical excitability was similar in patients and controls with a task-dependent modulation of MEPs (mean RMS MEPs: Early = 477 μV, Late prep = 854 μV, and Late inhib = 531 μV; effect of Phase, P F = 4.5, P = 0.02) with posthoc comparisons revealing a significant reduction in the Late inhib phase in patients compared to controls ( P = 0.02). In patients the SICI% during Late inhib correlated negatively with SSRT ( R = − 0.72, P inhib had longer SSRT. Conclusions To our knowledge this is the first study on task-dependent modulation of cortical excitability and intracortical inhibition in patients with schizophrenia. We show that patients with schizophrenia have reduced SICI during voluntary inhibition of a prepared finger lift. Surprisingly, there were no differences found in task performance or in MEP amplitudes during the task. These findings show that schizophrenia patients are capable of inhibiting motor tasks despite having reduced intracortical inhibition. This suggests the use of compensatory mechanisms in voluntary motor inhibition in stabilized schizophrenia patients.

Published
2013
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11. Chess-playing epilepsy: a case report with video-EEG and back averaging

Author

M W, Mann, B, Gueguen, S, Guillou, E, Debrand, and C, Soufflet

Subjects
Adult, Male, Electromyography, Valproic Acid, Video Recording, Electroencephalography, Epilepsies, Myoclonic, Signal Processing, Computer-Assisted, Neuropsychological Tests, Epilepsy, Reflex, Frontal Lobe, Play and Playthings, Games, Experimental, Humans, Anticonvulsants, Attention, Evoked Potentials, Problem Solving, Psychomotor Performance
Abstract

A patient suffering from juvenile myoclonic epilepsy experienced myoclonic jerks, fairly regularly, while playing chess. The myoclonus appeared particularly when he had to plan his strategy, to choose between two solutions or while raising the arm to move a chess figure. Video-EEG-polygraphy was performed, with back averaging of the myoclonus registered during a chess match and during neuropsychological testing with Kohs cubes. The EEG spike wave complexes were localised in the fronto-central region. [Published with video sequences].

Published
2004

12. [Refractory epilepsy]

Author

B, Gueguen

Subjects
Epilepsy, Evidence-Based Medicine, Seizures, Humans, Anticonvulsants, Electroencephalography, Prognosis, Drug Resistance, Multiple
Abstract

DRUG-RESISTANCE: Partial epilepsies are more often drug-resistant than generalized epilepsies, excepting severe syndromes which often begin in childhood. There is no need to try all anti-epileptic drugs before concluding as to the drug-resistant nature of the seizures. Refractory epilepsy can be diagnosed if well-conducted therapy (two alternative single-drug regimens with classical anti-seizure drugs and 1 or 2 trials with a two-drug regimen using new-generation compounds) is unsuccessful. MECHANISMS OF DRUG-RESISTANCE: The clinician should revisit the entire clinical history in patients with apparently refractory epilepsy, evaluating the treatments and the specific manifestations of the seizures. Conducted in a specialized center, this reassessment can recognize false cases of drug resistance such as non-epilepsy-related malaise or syncopes, inadequate regimens, or psychogenic "pseudo-seizures" which can be observed in patients with authentic epilepsy. Video-coupled EEG and ambulatory EEG may offer very useful information. SEVERAL EFFECTIVE THERAPEUTIC OPTIONS: Prognosis depends on effective and early control of seizures. This implies entertaining surgical excision of the epileptogenic focus early in the disease course. With several promising anti-epilepsy drugs, either recently marketed or under development, therapeutic indications in epilepsy should progress to more evidence-based prescriptions adapted to the type of epilepsy and the underlying cause.

Published
1999

13. [Indications for EEG in mental confusion and behavior problems]

Author

B, Gueguen, P, Raynaud, and M J, Guedj

Subjects
Paris, Emergency Services, Psychiatric, Humans, Electroencephalography, Behavioral Symptoms, Confusion
Abstract

Even in 1998 at the time of brain imaging, EEG recording is undoubtedly useful in clinical psychiatry when a true cerebral disease takes the form of an acute psychiatric disorder. Though the real place of EEG recording cannot be yet accurately quantified, it may help guide the diagnosis, as it is of either positive (ie, confirming the diagnosis via additional information) or negative (ie, rejecting various etiologies) value. Most of the time, only the former is considered in published studies. The clinical value of EEG recording in psychiatry emergency unit is therefore still not clearly established. The study of patients admitted during two years in the emergency unit at Sainte-Anne hospital (Paris, France) does not bring new conclusions, mainly because of bias in the modalities of admission and follow-up. As well, the role of EEG recording for the diagnosis of non-psychiatric diseases in psychiatry emergency units cannot be defined today. The authors review clinical situations where EEG recording is still highly advisable.

Published
1998

14. [Memory disorders in the elderly: complementary examinations--for whom?]

Author

B, Gueguen, J, Touchon, and D, Campion

Subjects
Diagnostic Imaging, Memory Disorders, Alzheimer Disease, Brain, Humans, Neurophysiology, Aged
Abstract

Recognizing the existence of memory disorders in elderly subjects necessarily involves developing a diagnostic strategy to identify the causes. Three types of complementary investigation are available: neurophysiological and neurobiological tests, and anatomical and functional brain imaging studies. Major efforts have been made to identify diagnostic markers on the electroencephalogram. Quantified EEG may have a certain value. However, it provides a plethora of data and there is no consensus on which items are most relevant on the EEG, whether the patient is awake or asleep. Evoked 'cognitive' potentials may also provide useful data, particularly to distinguish between the different types of degenerative dementia. Exaggerated pupil dilation in response to a mydriatric drug has also been put forward as a diagnostic test. The results, however, are controversial. For the time being there is no diagnostic laboratory parameter that can be used routinely, even if studies of the proteins tau and P97 are promising. Molecular genetics-based studies have identified a number of chromosomal abnormalities in certain families. Apart from studies of chromosome 19 and apolipoprotein 3, these markers have no practical utility. Allele sigma 4 is associated with a higher risk of Alzheimer's disease. Apolipoprotein E phenotyping can of course be of diagnostic value, but no more so than neuropsychological or neuroimaging methods. On the other hand, it is difficult to derive a predictive test. It also seems difficult to develop a diagnostic strategy without including brain imaging studies. The value of morphological imaging (CT, MRI) in the diagnosis of dementias is clear. Volumetric measurements of certain brain structures might be a useful diagnostic approach for early detection. Functional brain imaging methods (PET and SPECT) appear particularly suited to the diagnosis of degenerative dementias. The presence of functional abnormalities at onset, and, even before the first clinical signs appear, is clearly valuable.

Published
1998

15. P.3.b.004 Evidence of a cortical disinhibition in schizophrenia: a transcranial magnetic stimulation study

Author

Jean-Pierre Olié, B. Gueguen, C. Ben Amor, Marie-Odile Krebs, S. Douki, André Galinowski, and Marie-Chantal Bourdel

Subjects
Pharmacology, business.industry, medicine.medical_treatment, medicine.disease, Transcranial magnetic stimulation, Psychiatry and Mental health, Neurology, Schizophrenia, Disinhibition, Medicine, Pharmacology (medical), Neurology (clinical), Deep transcranial magnetic stimulation, medicine.symptom, business, Neuroscience, Biological Psychiatry
Published
2006
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18. Dystonia-parkinsonism syndrome resulting from a bullet injury in the midbrain

Author

P. Rondot, N Bathien, Yves Samson, A De Recondo, D. Fredy, J. De Recondo, and B. Gueguen

Subjects
Dystonia, Midbrain, Psychiatry and Mental health, business.industry, Rapid onset, Medicine, Surgery, Neurology (clinical), business, medicine.disease, Neuroscience, Research Article
Published
1994

19. [Topographical analysis of endogenous evoked potentials in depressed old people and in patients with Alzheimer's type dementia]

Author

M H, de Brionne, B, Gueguen, M C, Bourdel, S, Guillou, C, Derouesné, G, Loas, M F, Poirier, H, Loo, and B, Samuel-Lajeunesse

Subjects
Aged, 80 and over, Analysis of Variance, Brain Mapping, Depressive Disorder, Alzheimer Disease, Reaction Time, Brain, Humans, Electroencephalography, Middle Aged, Evoked Potentials, Aged
Abstract

Latencies, amplitudes and localization of the maximum of the peaks of late onset evoked responses have been studied in 3 groups of elderly people: normal, depressed and demented (probable dementia of Alzheimer type DAT) at the early stage of the disease. Evoked responses with an auditory oddball paradigm have been recorded with 16 electrodes in 2 situations: counting the target sounds, and motor response with measurement of the reaction time. No difference in amplitude was observed between the 3 groups. Only a significant difference for P3 latency was observed between the DAT and the depressed groups and only in the counting situation. The maximum P3 response was most often found on the anterior areas in the DAT group and in the posterior areas in the normal and depressed groups. The topographic localization of the P3 peak could therefore be of some help in the characterize of subjects with probable DAT at the early stage of the disease.

Published
1991

20. [EEG value for the prediction of the evolution of Alzheimer's type dementia]

Author

B, Gueguen, C, Derouesné, M C, Bourdel, S, Guillou, A, Rahal, E, Landre, J, Gasnault, and D, Ancri

Subjects
Aged, 80 and over, Male, Alzheimer Disease, Brain, Humans, Electroencephalography, Female, Middle Aged, Aged, Follow-Up Studies
Abstract

Twenty patients selected as probable dementia of the Alzheimer type (DAT) have been examined two times during a mean follow-up period of 14.5 months. Two groups have been distinguished at the end of this period: a cognitively impaired one and a stable one. EEG features at T1, at T2 or the difference T1-T2 does not allow an accurate and predictive discrimination between the two groups. But we cannot conclude that EEG is useless for prediction of the rate of progression of the disease in DAT because most of the cognitively stable patients are also stable for mean frequency. So mean frequency could be an interesting marker of evolutivity but this to be tested with more patients including more subjects reaching the severe stage of dementia.

Published
1991

21. [Comparison of SPECT and quantified EEG features in Alzheimer's type dementia]

Author

B, Gueguen, D, Ancri, C, Derouesné, M C, Bourdel, S, Guillou, and E, Landre

Subjects
Male, Tomography, Emission-Computed, Single-Photon, Analysis of Variance, Brain Mapping, Alzheimer Disease, Cerebrovascular Circulation, Brain, Humans, Electroencephalography, Female, Middle Aged, Aged
Abstract

Forty-one patients with probable dementia of the Alzheimer type (DAT) have been studied by computerized EEg (C-EEG) and single photon emission tomography (SPECT) using 123-IMP. Four groups have been distinguished according to SPECT hypoperfusion topography: frontal, temporo-parietal, fronto-parietal and fronto-temporo-parietal. C-EEG parameters were much more disturbed in the 2 latter than in the 2 former groups. Thus a normal C-EEG could indicate a dominant frontal or temporo-parietal form of DAT. Therefore some bias due to duration or rate of disease progression cannot be excluded. So far the important finding is that EEG changes are diffuse and do not reflect the topography of SPECT hypoperfusion questioning the value of EEG topographical analysis in DTA.

Published
1991

22. [Quantified EEG in the diagnosis of Alzheimer's type dementia]

Author

B, Gueguen, C, Derouesné, M C, Bourdel, S, Guillou, E, Landre, J, Gaches, H, Hossard, D, Ancri, and M, Mann

Subjects
Aged, 80 and over, Male, Brain Mapping, Alzheimer Disease, Data Interpretation, Statistical, Brain, Discriminant Analysis, Humans, Electroencephalography, Female, Signal Processing, Computer-Assisted, Middle Aged, Aged
Abstract

79 subjects (mean age 70.2 ans, 31 males, 48 females) selected as probable dementia of the Alzheimer type, at the early stage of the disease and 17 normal aged people (mean age: 72.2, 5 males, 12 females) were recorded with a 16 channel computerized-EEG (C-EEG) with topographical analysis of the observed changes and with classical visual analysis of the EEG. Quite simple C-EEG parameters as mean dominant frequency (MF) and alpha to theta ratio are able to discriminate patients from normal with a greater accuracy than visual analysis. The values of 8.6 for the MF and 1.3 for the alpha/theta ratio are proposed as cut off values between normal and DAT patients. The topographical analysis appear to be of no additional usefulness in the discrimination of the two groups.

Published
1991

24. Effect of clozapine and olanzapine on cortical excitability in schizophrenia

Author

C. Ben Amor, Marie-Chantal Bourdel, R. Waismann, André Galinowski, B. Gueguen, Q. Debray, B. Granger, Jean-Pierre Olié, and Marie-Odile Krebs

Subjects
Olanzapine, medicine.medical_specialty, Risperidone, business.industry, medicine.medical_treatment, Therapeutic effect, Stimulation, medicine.disease, Psychiatry and Mental health, Endocrinology, Schizophrenia, Disinhibition, Internal medicine, Medicine, medicine.symptom, business, Antipsychotic, Clozapine, medicine.drug
Abstract

Cortical excitability is modified in schizophrenia [1] but the effect of antipsychotic drugs has been disputed. In particular, patients receiving olanzapine and risperidone showed less cortical disinhibition compared to untreated schizophrenic subjects [2]. However, despite the observed increase, the Resting Motor Threshold (RMT) remained inferior to the RMT in normal controls, and the Transcallosal Conduction Time (TCT) did not change.There is no comparative study of the effect of clozapine, an effective antipsychotic with proconvulsant properties.We studied cortical excitability by transmagnetic stimulation in stabilized schizophrenic patients treated by clozapine (n=10), olanzapine (n=10) compared to healthy volunteers (n=10).The aim of this study was to extend previous research into inhibitory deficits in schizophrenia and to compare the effect of clozapine and olanzapine on neurophysiological parameters such as RMT, Intracortical Inhibition (ICI), Intracortical Facilitation (ICF), Cortical Silence Period (CSP) and Transcallosal Inhibition (TI).In clozapine treated patients, the RMT and ICI were significantly lower (p

Published
2007
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30. Clinical and neurophysiological evaluation of 3 doses of S120242 (50, 100, 200 mg o.d.) during repeated oral administration (7 days) in 12 out-patients with mild to moderate Alzheimer's disease

Author

B. Gueguen, L. Ouss, D. Guez, Lucette Lacomblez, C. Derouesné, P. Homeyer, Eric Neuman, S. Barrandon, B. Renault, M. Malbezin, and M. Vanderlinden

Subjects
Aging, medicine.medical_specialty, business.industry, General Neuroscience, Disease, medicine.disease, Out patients, Oral administration, Internal medicine, Medicine, Neurology (clinical), Geriatrics and Gerontology, Alzheimer's disease, business, Developmental Biology
Published
1994
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31. Éditorial

Author

B Gueguen

Subjects
Neurology, Physiology (medical), Neurology (clinical), General Medicine
Published
1991
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33. Cafeine et cartographie EEG: Effets d'une tache visuospatiale chez des volontaires sains. Strategie d'analyse des donnees electropharmacologiques

Author

B. Gueguen, P. Etevenon, P. Peron-Magnan, P. Deniker, J.P. Boulenger, M. Toussaint, H. Loo, and S. Guillou

Subjects
medicine.medical_specialty, genetic structures, medicine.diagnostic_test, business.industry, Alpha (ethology), General Medicine, Audiology, Electroencephalography, Placebo, Normal volunteers, Neurology, Physiology (medical), Statistical significance, Medicine, Spectral analysis, Neurology (clinical), business, Delta activity, Right anterior
Abstract

A group of 10 subjects, normal volunteers (6 men, 4 women), mean age 27.2 years, right-handers, has been selected for a double-blind study of caffeine effects (400 mg per os) versus placebo. One week delay separated the two EEG sessions quantified by spectral analysis. During each session (16 EEG channels, common reference), each subject was recorded four times: 2.5 min, in eyes-closed condition, under diffuse attention, followed by 2.5 min, during a visuo-spatial task ("eyes open" condition: presentation of a picture). These two EEG recordings were obtained before the oral administration and repeated 1 hr after the administration of caffeine or placebo. Individual and group results presented globally: 1) an increase in mean frequencies of alpha activity in "eyes closed" condition, and of delta activity in "eyes open" condition; 2) a decrease of alpha activity amplitudes (both RMS and % values) in both conditions; 3) a decrease of total RMS amplitudes in "eyes closed" condition; 4) an increase of relative % amplitudes for beta 2% fast activity in the "eyes open condition". These results characterize the psycho-stimulant effects of caffeine, especially over the left temporal area which was confirming an initial statistical hypothesis of specific cerebral local activation. The non-parametric permutation tests of Fisher, were not always reaching statistical significance for the same EEG channel quantified by one of the 17 analyzed spectral parameters, except on the left temporal area. During the visuo-spatial task, the decrease in alpha amplitudes (RMS and %) was also statistically significant, but over larger areas: over left and right temporal, central and parietal regions. In both conditions, eyes closed and eyes open, the alpha RMS amplitude was also decreased over the right anterior frontal area.

Published
1988
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34. Iontophoretic investigation of identified SFO angiotensin responsive neurons firing in relation to blood pressure changes

Author

R. de Beaurepaire, S.N. Thornton, B. Gueguen, S. Ishibashi, and Stylianos Nicolaidis

Subjects
Male, medicine.medical_specialty, Blood Pressure, Vasodilation, Inhibitory postsynaptic potential, Stereotaxic Techniques, Internal medicine, Renin–angiotensin system, medicine, Animals, Neurons, Iontophoresis, business.industry, Angiotensin II, General Neuroscience, Electric Conductivity, Rats, Inbred Strains, Neurosecretory Systems, Electric Stimulation, Subfornical organ, Rats, medicine.anatomical_structure, Blood pressure, Endocrinology, business, Subfornical Organ, Antidiuretic
Abstract

Activity of 29 histologically identified units in the SFO was recorded in parallel to blood pressure monitoring. The responsiveness of these units to angiotensin II (AII) applied either iontophoretically or via the carotid artery (IC) was investigated together with the capacity of the vasodilator substance NO2- to block the AII response. Fifty-five% of the SFO units responded to iontophoretic application of AII (vs. 27% in the surrounding areas). SFO units were also activated by blood pressure depressions, either as a mirror image (type B) or only restricted to the initial descendent phase of the hypotensive wave (type A). But 8 of the 29 units responded in a mixed A and B fashion, i.e., dramatic firing in the very beginning of the hypotension followed by a sustained moderate response until recovery. Hypertensive spontaneous fluctuations rarely and inconsistently elicited an inhibitory response. An unexpected phenomenon of a hypotensive response following IC injections of low doses of AII was observed and used in this investigation. These observations together with the finding that vasoplegics inhibited unit firing suggest that the SFO is equipped with units able to sense a reduction in local vessels' calibre and fire in relation to it. When activated chemically, electrically or mechanically these units may then trigger hypertensive, antidiuretic and drinking responses.

Published
1983
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35. Electroencephalographic Cartography

Author

P. Etevenon, J. Gaches, C. Debouzy, B. Gueguen, and P. Peron-Magnan

Subjects
Psychiatry and Mental health, Neuropsychology and Physiological Psychology, Biological Psychiatry
Published
1985
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37. EEG cartography profile of caffeine in normals

Author

P, Etevenon, P, Péron-Magnan, J P, Boulenger, D, Tortrat, S, Guillou, M, Toussaint, B, Gueguen, P, Deniker, and E, Zarifian

Subjects
Adult, Male, Caffeine, Humans, Electroencephalography, Female
Published
1986

38. [Role of electroencephalography in the diagnosis of acute cerebral diseases]

Author

B, Gueguen, R, Brechet, C, Sicard, M, Dondey, H P, Cathala, J, Gaches, O, Lyon-Caen, and D, Rougemont

Subjects
Brain Diseases, Acute Disease, Humans, Electroencephalography, Tomography, X-Ray Computed
Abstract

It appears from a study of 100 cases of acute cerebral disease that electroencephalography is valuable as part of the diagnosis strategy and not only to establish the correct final diagnosis. This examination therefore plays a non-negligible role in neurological practice. In a number of diseases it provides information that no other examination can provide, being a dynamic, functional method of brain tissue analysis.

Published
1987

39. [EEG mapping in partial epilepsy]

Author

B, Gueguen and J, Gaches

Subjects
Adult, Male, Adolescent, Epilepsy, Temporal Lobe, Fourier Analysis, Humans, Electroencephalography, Female, Epilepsies, Partial, Middle Aged, Tomography, X-Ray Computed
Abstract

Even if mathematic treatment of EEG signals by Fast Fourier Transformation (FFT) in cases of transient epileptic discharges is still controversial, this method has been applied to 21 cases of epileptic partial seizures. Examples are shown, and compared to CT-Scan data. In 17 cases, EEG mapping identified alterations of basic activities upon a definite area. In addition, a focal peak of maximal alterations displacing itself into the limits of the whole epileptogenic area is demonstrated; it is furthermore suggested that the power spectrum keeps, especially during seizures, a peculiar ("combing") morphology, possibly specific of epileptic diseases.

Published
1986

40. [Value of quantitative EEG and EEG mapping in medicine]

Author

P, Etévenon, P, Péron-Magnan, B, Gueguen, M, Ghanem, J, Gaches, and P, Deniker

Subjects
Brain Diseases, Brain Mapping, Cerebrovascular Disorders, Fourier Analysis, Image Interpretation, Computer-Assisted, Minicomputers, Humans, Electroencephalography, Signal Processing, Computer-Assisted
Abstract

Quantitative EEG consists in digitising the EEG from one or several leads and then mathematically processing the signal usually by Fourier spectral analysis. A reduction of the digital information gives characteristic parameters (frequency, amplitude or power, asymmetry, etc.), which can themselves be averaged and submitted to different statistical analysis. Quantitative EEG is particularly suitable for clinical electropharmacology for the assessment of the profiles of psychotropic drugs, for pharmacokinetic correlations of dose-effect relationships and studies of drug bioavailability. The signals obtained from schizophrenic and depressed patients have well defined quantitative EEG characteristics: dissymmetry of the amplitude and hypovariability of the EEG signals. EEg mapping is performed by computer processing of 16 simultaneous EEG lead recordings. This new form of medical imaging is fast, relatively economical and non-invasive, and it is used in psychophysiology to study cognitive tasks and the states of vigilance and sleep. It is also used to study the EEG topography of cerebrovascular accidents, brain tumours, cranial trauma, cerebral degeneration and dementia, and the EEGs of psychiatric patients on psychotropic drugs. EEG mapping represents not only a static and statistical approach by drawing the averaged maps of groups of patients but also a dynamic approach by the recording of sequential individual maps presented as an animated film. The results of this method can be correlated with other medical imaging techniques used to investigate the central nervous system.

Published
1987

41. Electroencephalographic Cartography. I. By means of mini- or microcomputers. Reliability and interest of this electrical non-invasive brain imagery

Author

P, Etevenon, J, Gaches, C, Debouzy, B, Gueguen, and P, Peron-Magnan

Subjects
Adult, Male, Fourier Analysis, Microcomputers, Minicomputers, Humans, Electroencephalography
Abstract

We have recorded control subjects, neurological and psychiatric patients (n = 217 sequences recorded over both hemispheres). Minicomputers (HP Fourier analyzer, HP 1000) for spectral analysis provided 10 spectral parameters over 5 spectral frequency bands (delta, theta, alpha, beta 1, beta 2, raw EEG). For each recorded sequence, 90 EEG maps could be computed over both hemispheres. Topo-EEGs were stored in an EEG image data bank. An EEG mapping microcomputer system linked with a digital polygraph (Alvar Electronic, REEGA 2000) has been used simultaneously. White noises have been fed into both computers for testing spatial resolution. Ten topo-EEGs have been recorded in control subjects and patients. The microcomputer system has provided very reliable topographical results when compared to similar maps generated by the minicomputer. A common average reference has been used. First clinical applications have been studied (brain strokes, brain tumors). The method appears very reliable in comparison with CT scans.

Published
1985

42. Severe chorea after acute carbon monoxide poisoning

Author

P. Rondot, M H Marion, P Davous, and B Gueguen

Subjects
Adult, congenital, hereditary, and neonatal diseases and abnormalities, Internal capsule, genetic structures, Chlorpromazine, Poison control, Computed tomography, Carbon Monoxide Poisoning, Chorea, mental disorders, Medicine, Humans, medicine.diagnostic_test, business.industry, Carbon monoxide poisoning, Electromyography, Brain, medicine.disease, humanities, nervous system diseases, Psychiatry and Mental health, Anesthesia, Acute exposure, Surgery, Female, Neurology (clinical), medicine.symptom, business, Tomography, X-Ray Computed, After treatment, medicine.drug, Follow-Up Studies, Research Article
Abstract

Ten days after an acute exposure to carbon monoxide, a 33-year-old woman exhibited severe chorea. CT scan revealed bilateral lucencies of the pallidum and anterior arm of the internal capsule. Chorea was successfully treated by chlorpromazine and did not relapse after treatment withdrawal. The mechanism of chorea in acute carbon monoxide poisoning is discussed.

Published
1986

44. EEG Mapping in Pathological Aging and Dementia: Utility for Diagnosis and Therapeutic Evaluation

Author

J. De Recondo, P. Etevenon, D. Plancon, J. Gaches, B. Gueguen, and P. Rondot

Subjects
medicine.diagnostic_test, Eeg mapping, medicine, Dementia, Quantified eeg, Electroencephalography, Therapeutic evaluation, medicine.disease, Cognitive impairment, Psychology, Pathological, Visual methods, Clinical psychology
Abstract

Quantified EEG (Remond 1961; Drohocki 1968; Walter and Brazier 1968; Dolce and Kunkel 1975; Etevenon 1977) and mapping (Lehmann 1971; Ragot and Remond 1978; Duffy et al. 1981; Buehsbaum etal. 1982) have allowed more precise and reliable EEG analysis than visual methods. However, while the place of these methods in daily clinical practice is being debated they are giving rise to an excess of pictorial and numerical data. Much work has been published concerning aging and dementia (Duffy et al. 1984 a, b; Coben et al. 1985; Penttila etal. 1985; Gueguen etal. 1986; Senant etal. 1986), but only a few studies in the past 2 years have really used EEG as a tool for diagnosis or for therapeutic evaluation (Cutler et al. 1985; Little et al. 1985; Bruno et al. 1986; Delwaie et al. 1986; Partanen et al. 1986; Schwartz and Kolstaedt 1986). EEG changes occur early in dementia and are well correlated with the stage of cognitive impairment (Coben etal. 1985; Penttila etal. 1985). We report here preliminary results concerning the usefulness of quantified EEG methods in diagnosis and treatment of pathological aging.

Published
1989
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45. Neuronal responses in subfornical organ and other regions to angiotensin II applied by various routes

Author

S. Ishibashi, Stylianos Nicolaidis, Y. Oomura, and B. Gueguen

Subjects
Male, medicine.medical_specialty, Hippocampus, Action Potentials, Stimulation, Dinoprost, Internal medicine, medicine, Premovement neuronal activity, Animals, Circumventricular organs, Injections, Intraventricular, Sodium Nitrite, business.industry, General Neuroscience, Angiotensin II, Prostaglandins F, Rats, Inbred Strains, Iontophoresis, Neurosecretory Systems, Subfornical organ, Rats, Endocrinology, medicine.anatomical_structure, Carotid Arteries, nervous system, Injections, Intra-Arterial, Cerebral cortex, cardiovascular system, sense organs, medicine.symptom, business, hormones, hormone substitutes, and hormone antagonists, Vasoconstriction, Subfornical Organ
Abstract

Effects of Angiotensin II (AII) and of signals of hydromineral deficiencies on neuronal firing in the subfornical organ (SFO) and the surrounding regions of the rat were examined. AII was applied in three ways: electrophoresis, intracarotid injection, or intracerebroventricular injection. Seventeen SFO neurons (52%) were facilitated by electrophoretic AII and one (3%) was inhibited (AII-responding neurons). Neurons in other regions (cerebral cortex, nucleus triangularis septi, hippocampus, nucleus periventricularis) were also facilitated (23%) or inhibited (14%). Prostaglandin (PG)F 2 , a universal vasoconstrictor, produced an effect similar to that by AII on neuronal activity of the SFO and surrounding regions, and this effect was antagonized by (NO 2 − ), a vasoplegic agent. Intracarotid injection of AH caused biphasic facilitation of SFO activity. The second increase correlates with changes in blood pressure. Intraventricular injection of AII caused drastic and long lasting excitation of SFO activity. Simultaneous intraventricular application of NO 2 − blocked the AII effect on SFO neurons but not on blood pressure. Hypovolemia or cerebrospinal fluid withdrawal that might cause mechanical stimulation of circumventricular organs increased SFO neuronal activity. These results are compatible with the vasoconstriction hypothesis of an indirect effect of All through change in diameter of the vasa that surround neurons.

Published
1985

46. Vascular malformations of the spinal cord: intrathecal perimedullary arteriovenous fistulas fed by medullary arteries

Author

J. J. Merland, B. Gueguen, M. C. Riche, and Rey A

Subjects
Adult, Male, medicine.medical_specialty, Cord, Adolescent, medicine.medical_treatment, Fistula, Medullary Artery, medicine, Humans, Embolization, medicine.diagnostic_test, business.industry, Arteriovenous malformation, medicine.disease, Spinal cord, Surgery, Radiography, medicine.anatomical_structure, Spinal Cord, Angiography, Arteriovenous Fistula, Female, Neurology (clinical), Radiology, business, Myelography
Abstract

We studied eleven patients with intrathecal extramedullary arteriovenous fistulas identified by selective angiography and myelography. The fistulas were located on the surface of the cord, fed by medullary arteries. Angiography distinguished three separate types that gave identical clinical disorders. Therapeutic results of surgery and embolization allowed specific indications to be defined for treatment of each type of fistula.

Published
1987

47. EEG Mapping in Epilepsy

Author

J. Gaches and B. Gueguen

Subjects
Physics, Cooley–Tukey FFT algorithm, Photic Stimulation, business.industry, Fast Fourier transform, Pattern recognition, EEG-fMRI, medicine.disease, Beta band, Epilepsy, Alpha rhythm, Eeg mapping, medicine, Artificial intelligence, business
Abstract

Despite the fact that using Fast Fourier transforms (FFT) to non-stationary signals is somewhat questionable, we have applied this method since 1982 (Etevenon et al. 1982; Gueguen and Gaches 1986) in cases of epilepsy.

Published
1989
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48. Chorea and polycythaemia

Author

P. Bouche, J. L. Mas, C. Derouesne, P. Castaigne, B. Gueguen, and B. Varet

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, Polycythaemia, medicine.medical_specialty, Neurology, genetic structures, medicine.medical_treatment, Polycythemia vera, Chorea, hemic and lymphatic diseases, mental disorders, medicine, Humans, Bloodletting, Polycythemia Vera, Neuroradiology, Aged, business.industry, medicine.disease, Dermatology, Pathophysiology, nervous system diseases, Female, Neurology (clinical), medicine.symptom, business
Abstract

Two patients with chorea and polycythaemia vera are described. The literature on this rare association is reviewed and its pathophysiology discussed.

Published
1985

49. [Clinical, electrophysiologic and endocrine effects of the perfusion of high doses of TRH in amyotrophic lateral sclerosis]

Author

B, Gueguen, J, Puymirat, D, Grouselle, M L, Piketty, J P, Bleton, M C, Bourdel, and P, Rondot

Subjects
Adult, Male, Amyotrophic Lateral Sclerosis, Thyrotropin, Luteinizing Hormone, Middle Aged, Prolactin, Thyroxine, Growth Hormone, Acetylcholinesterase, Humans, Triiodothyronine, Female, Follicle Stimulating Hormone, Infusions, Intravenous, Thyrotropin-Releasing Hormone, Aged, Muscle Contraction
Abstract

Eight patients with amyotrophic lateral sclerosis received 500 mg TRH by IV infusion, at a progressive rate during 3 hours. Only 3 patients noted subjective improvement of strength. Clinical muscular testing and H response study failed to show any change. Moreover modifications of the prolactin, growth hormone, TSH and T3 serum levels raise a question concerning the tolerance with long term utilization of TRH.

Published
1988

50. [Caffeine and EEG mapping: effects of visuo-spatial task in healthy volunteers]

Author

P, Etevenon, P, Peron-Magnan, S, Guillou, M, Toussaint, B, Gueguen, J P, Boulenger, P, Deniker, and H, Loo

Subjects
Adult, Male, Double-Blind Method, Caffeine, Visual Perception, Administration, Oral, Humans, Spatial Behavior, Electroencephalography, Female, Visual Pathways, Temporal Lobe
Abstract

A group of 10 subjects, normal volunteers (6 men, 4 women), mean age 27.2 years, right-handers, has been selected for a double-blind study of caffeine effects (400 mg per os) versus placebo. One week delay separated the two EEG sessions quantified by spectral analysis. During each session (16 EEG channels, common reference), each subject was recorded four times: 2.5 min, in eyes-closed condition, under diffuse attention, followed by 2.5 min, during a visuo-spatial task ("eyes open" condition: presentation of a picture). These two EEG recordings were obtained before the oral administration and repeated 1 hr after the administration of caffeine or placebo. Individual and group results presented globally: 1) an increase in mean frequencies of alpha activity in "eyes closed" condition, and of delta activity in "eyes open" condition; 2) a decrease of alpha activity amplitudes (both RMS and % values) in both conditions; 3) a decrease of total RMS amplitudes in "eyes closed" condition; 4) an increase of relative % amplitudes for beta 2% fast activity in the "eyes open condition". These results characterize the psycho-stimulant effects of caffeine, especially over the left temporal area which was confirming an initial statistical hypothesis of specific cerebral local activation. The non-parametric permutation tests of Fisher, were not always reaching statistical significance for the same EEG channel quantified by one of the 17 analyzed spectral parameters, except on the left temporal area. During the visuo-spatial task, the decrease in alpha amplitudes (RMS and %) was also statistically significant, but over larger areas: over left and right temporal, central and parietal regions. In both conditions, eyes closed and eyes open, the alpha RMS amplitude was also decreased over the right anterior frontal area.

Published
1988

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