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1. Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders

Author: M. D. Hettwer, S. Larivière, B. Y. Park, O. A. van den Heuvel, L. Schmaal, O. A. Andreassen, C. R. K. Ching, M. Hoogman, J. Buitelaar, D. van Rooij, D. J. Veltman, D. J. Stein, B. Franke, T. G. M. van Erp, ENIGMA ADHD Working Group, ENIGMA Autism Working Group, ENIGMA Bipolar Disorder Working Group, ENIGMA Major Depression Working Group, ENIGMA OCD Working Group, ENIGMA Schizophrenia Working Group, N. Jahanshad, P. M. Thompson, S. I. Thomopoulos, R. A. I. Bethlehem, B. C. Bernhardt, S. B. Eickhoff, and S. L. Valk
Subjects: Science
Abstract: Neuropsychiatric disorders may have shared features. Here the authors identified hubs of transdiagnostic co-alteration networks using meta-analytical maps of ENIGMA neuroimaging data for six neurodevelopmental and psychiatric disorders.
Published: 2022
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2. Discovering the shared biology of cognitive traits determined by genetic overlap

Author: J.P.O.F.T. Guimaraes, J. Bralten, C.U. Greven, B. Franke, E. Sprooten, and C.F. Beckmann
Subjects: Shared genetics, Functional imaging meta-analysis, Brain activation overlap, Cognition, Biological convergence, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Investigating the contribution of biology to human cognition has assumed a bottom-up causal cascade where genes influence brain systems that activate, communicate, and ultimately drive behavior. Yet few studies have directly tested whether cognitive traits with overlapping genetic underpinnings also rely on overlapping brain systems. Here, we report a step-wise exploratory analysis of genetic and functional imaging overlaps among cognitive traits. We used twin-based genetic analyses in the human connectome project (HCP) dataset (N = 486), in which we quantified the heritability of measures of cognitive functions, and tested whether they were driven by common genetic factors using pairwise genetic correlations. Subsequently, we derived activation maps associated with cognitive tasks via functional imaging meta-analysis in BrainMap (N = 4484), and tested whether cognitive traits that shared genetic variation also exhibited overlapping brain activation. Our genetic analysis determined that six cognitive measures (cognitive flexibility, no-go continuous performance, fluid intelligence, processing speed, reading decoding and vocabulary comprehension) were heritable (0.3
Published: 2020
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3. Variation in a range of mTOR-related genes associates with intracranial volume and intellectual disability

Author: M. R. F. Reijnders, M. Kousi, G. M. van Woerden, M. Klein, J. Bralten, G. M. S. Mancini, T. van Essen, M. Proietti-Onori, E. E. J. Smeets, M. van Gastel, A. P. A. Stegmann, S. J. C. Stevens, S. H. Lelieveld, C. Gilissen, R. Pfundt, P. L. Tan, T. Kleefstra, B. Franke, Y. Elgersma, N. Katsanis, and H. G. Brunner
Subjects: Science
Abstract: The mTOR pathway is a key regulator of normal brain development. Here, the authors identify de novo mutations in RHEB, an mTOR activator protein, in patients with intellectual disability associated with megalencephaly and find a role for RHEB in regulating neuronal soma size and migration in vitro and in vivo.
Published: 2017
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4. Constraining interactions mediated by axion-like particles with ultracold neutrons

Author: S. Afach, G. Ban, G. Bison, K. Bodek, M. Burghoff, M. Daum, M. Fertl, B. Franke, Z.D. Grujić, V. Hélaine, M. Kasprzak, Y. Kermaïdic, K. Kirch, P. Knowles, H.-C. Koch, S. Komposch, A. Kozela, J. Krempel, B. Lauss, T. Lefort, Y. Lemière, A. Mtchedlishvili, O. Naviliat-Cuncic, F.M. Piegsa, G. Pignol, P.N. Prashanth, G. Quéméner, D. Rebreyend, D. Ries, S. Roccia, P. Schmidt-Wellenburg, A. Schnabel, N. Severijns, J. Voigt, A. Weis, G. Wyszynski, J. Zejma, J. Zenner, and G. Zsigmond
Subjects: Physics, QC1-999
Abstract: We report a new limit on a possible short range spin-dependent interaction from the precise measurement of the ratio of Larmor precession frequencies of stored ultracold neutrons and Hg199 atoms confined in the same volume. The measurement was performed in a ∼1μT vertical magnetic holding field with the apparatus searching for a permanent electric dipole moment of the neutron at the Paul Scherrer Institute. A possible coupling between freely precessing polarized neutron spins and unpolarized nucleons of the wall material can be investigated by searching for a tiny change of the precession frequencies of neutron and mercury spins. Such a frequency change can be interpreted as a consequence of a short range spin-dependent interaction that could possibly be mediated by axions or axion-like particles. The interaction strength is proportional to the CP violating product of scalar and pseudoscalar coupling constants gSgP. Our result confirms limits from complementary experiments with spin-polarized nuclei in a model-independent way. Limits from other neutron experiments are improved by up to two orders of magnitude in the interaction range of 10−6
Published: 2015
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5. A measurement of the neutron to 199Hg magnetic moment ratio

Author: S. Afach, C.A. Baker, G. Ban, G. Bison, K. Bodek, M. Burghoff, Z. Chowdhuri, M. Daum, M. Fertl, B. Franke, P. Geltenbort, K. Green, M.G.D. van der Grinten, Z. Grujic, P.G. Harris, W. Heil, V. Hélaine, R. Henneck, M. Horras, P. Iaydjiev, S.N. Ivanov, M. Kasprzak, Y. Kermaïdic, K. Kirch, A. Knecht, H.-C. Koch, J. Krempel, M. Kuźniak, B. Lauss, T. Lefort, Y. Lemière, A. Mtchedlishvili, O. Naviliat-Cuncic, J.M. Pendlebury, M. Perkowski, E. Pierre, F.M. Piegsa, G. Pignol, P.N. Prashanth, G. Quéméner, D. Rebreyend, D. Ries, S. Roccia, P. Schmidt-Wellenburg, A. Schnabel, N. Severijns, D. Shiers, K.F. Smith, J. Voigt, A. Weis, G. Wyszynski, J. Zejma, J. Zenner, and G. Zsigmond
Subjects: Physics, QC1-999
Abstract: The neutron gyromagnetic ratio has been measured relative to that of the 199Hg atom with an uncertainty of 0.8 ppm. We employed an apparatus where ultracold neutrons and mercury atoms are stored in the same volume and report the result γn/γHg=3.8424574(30). Keywords: Ultracold neutrons, Mercury atoms, Magnetic moment, Gyromagnetic ratio
Published: 2014
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6. Active compensation of magnetic field distortions based on vector spherical harmonics field description

Author: G. Wyszyński, K. Bodek, S. Afach, G. Bison, Z. Chowdhuri, M. Daum, B. Franke, S. Komposch, B. Lauss, D. Ries, G. Zsigmond, M. Perkowski, D. Rozpedzik, J. Zejma, M. Fertl, P. A. Koss, N. Severijns, E. Wursten, K. Kirch, A. Kozela, G. Quéméner, and A. Schnabel
Subjects: Physics, QC1-999
Abstract: An analytic solution to the magnetostatic inverse problem in the framework of vector spherical harmonic basis functions is presented. This formalism is used for the design of a spherical magnetic field compensation system and its performance is compared with an already existing rectangular coil system. The proposed set of spherical coils with 15 degrees of freedom achieves a shielding factor of 1000 or better in a large part of the volume enclosed by the coils for a dipolar type external perturbation.
Published: 2017
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7. Fast-switching magnet serving a spallation-driven ultracold neutron source

Author: S. Ahmed, E. Altiere, T. Andalib, M. J. Barnes, B. Bell, C. P. Bidinosti, Y. Bylinsky, J. Chak, M. Das, C. A. Davis, F. Fischer, B. Franke, M. T. W. Gericke, P. Giampa, M. Hahn, S. Hansen-Romu, K. Hatanaka, T. Hayamizu, B. Jamieson, D. Jones, K. Katsika, S. Kawasaki, T. Kikawa, W. Klassen, A. Konaka, E. Korkmaz, F. Kuchler, L. Kurchaninov, M. Lang, L. Lee, T. Lindner, K. W. Madison, J. Mammei, R. Mammei, J. W. Martin, R. Matsumiya, E. Miller, T. Momose, R. Picker, E. Pierre, W. D. Ramsay, Y.-N. Rao, W. R. Rawnsley, L. Rebenitsch, W. Schreyer, S. Sidhu, S. Vanbergen, W. T. H. van Oers, Y. X. Watanabe, and D. Yosifov
Subjects: Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: A fast-switching, high-repetition-rate magnet and power supply have been developed for and operated at TRIUMF, to deliver a proton beam to the new ultracold neutron (UCN) facility. The facility possesses unique operational requirements: a time-averaged beam current of 40 μA with the ability to switch the beam on or off for several minutes. These requirements are in conflict with the typical operation mode of the TRIUMF cyclotron which delivers nearly continuous beam to multiple users. To enable the creation of the UCN facility, a beam-sharing arrangement with another facility was made. The beam sharing is accomplished by the fast-switching (kicker) magnet which is ramped in 50 μs to a current of 193 A, held there for approximately 1 ms, then ramped down in the same short period of time. This achieves a 12 mrad deflection which is sufficient to switch the proton beam between the two facilities. The kicker magnet relies on a high-current, low-inductance coil connected to a fast-switching power supply that is based on insulated-gate bipolar transistors (IGBTs). The design and performance of the kicker magnet system and initial beam delivery results are reported.
Published: 2019
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8. Shared genetic influences on resting‐state functional networks of the brain

Author: João P.O.F.T. Guimarães, E. Sprooten, C. F. Beckmann, B. Franke, and J. Bralten
Subjects: Brain Mapping, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], Radiological and Ultrasound Technology, Brain, 220 Statistical Imaging Neuroscience, Magnetic Resonance Imaging, Language in Interaction, Neurology, Humans, Radiology, Nuclear Medicine and imaging, Neurology (clinical), Nerve Net, Anatomy, Genome-Wide Association Study
Abstract: Contains fulltext : 248882.pdf (Publisher’s version ) (Open Access) The amplitude of activation in brain resting state networks (RSNs), measured with resting-state functional magnetic resonance imaging, is heritable and genetically correlated across RSNs, indicating pleiotropy. Recent univariate genome-wide association studies (GWASs) explored the genetic underpinnings of individual variation in RSN activity. Yet univariate genomic analyses do not describe the pleiotropic nature of RSNs. In this study, we used a novel multivariate method called genomic structural equation modeling to model latent factors that capture the shared genomic influence on RSNs and to identify single nucleotide polymorphisms (SNPs) and genes driving this pleiotropy. Using summary statistics from GWAS of 21 RSNs reported in UK Biobank (N = 31,688), the genomic latent factor analysis was first conducted in a discovery sample (N = 21,081), and then tested in an independent sample from the same cohort (N = 10,607). In the discovery sample, we show that the genetic organization of RSNs can be best explained by two distinct but correlated genetic factors that divide multimodal association networks and sensory networks. Eleven of the 17 factor loadings were replicated in the independent sample. With the multivariate GWAS, we found and replicated nine independent SNPs associated with the joint architecture of RSNs. Further, by combining the discovery and replication samples, we discovered additional SNP and gene associations with the two factors of RSN amplitude. We conclude that modeling the genetic effects on brain function in a multivariate way is a powerful approach to learn more about the biological mechanisms involved in brain function.
Published: 2022
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9. Predictive role of atrial fibrillation in cognitive decline: a systematic review and meta-analysis of 2.8 million individuals

Author: Yu Han Koh, Leslie Z W Lew, Kyle B Franke, Adrian D Elliott, Dennis H Lau, Anand Thiyagarajah, Dominik Linz, Margaret Arstall, Phillip J Tully, Bernhard T Baune, Dian A Munawar, and Rajiv Mahajan
Subjects: Stroke, Risk Factors, Cerebral Small Vessel Diseases, Physiology (medical), Atrial Fibrillation, Odds Ratio, Humans, Cognitive Dysfunction, Cardiology and Cardiovascular Medicine
Abstract: Aims To systematic review and meta-analyse the association and mechanistic links between atrial fibrillation (AF) and cognitive impairment. Methods and results PubMed, EMBASE, and Cochrane Library were searched up to 27 March 2021 and yielded 4534 citations. After exclusions, 61 were analysed; 15 and 6 studies reported on the association of AF and cognitive impairment in the general population and post-stroke cohorts, respectively. Thirty-six studies reported on the neuro-pathological changes in patients with AF; of those, 13 reported on silent cerebral infarction (SCI) and 11 reported on cerebral microbleeds (CMB). Atrial fibrillation was associated with 39% increased risk of cognitive impairment in the general population [n = 15: 2 822 974 patients; hazard ratio = 1.39; 95% confidence interval (CI) 1.25–1.53, I2 = 90.3%; follow-up 3.8–25 years]. In the post-stroke cohort, AF was associated with a 2.70-fold increased risk of cognitive impairment [adjusted odds ratio (OR) 2.70; 95% CI 1.66–3.74, I2 = 0.0%; follow-up 0.25–3.78 years]. Atrial fibrillation was associated with cerebral small vessel disease, such as white matter hyperintensities and CMB (n = 8: 3698 patients; OR = 1.38; 95% CI 1.11–1.73, I2 = 0.0%), SCI (n = 13: 6188 patients; OR = 2.11; 95% CI 1.58–2.64, I2 = 0%), and decreased cerebral perfusion and cerebral volume even in the absence of clinical stroke. Conclusion Atrial fibrillation is associated with increased risk of cognitive impairment. The association with cerebral small vessel disease and cerebral atrophy secondary to cardioembolism and cerebral hypoperfusion may suggest a plausible link in the absence of clinical stroke. PROSPERO CRD42018109185.
Published: 2022
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10. Impact of health literacy and its interventions on health outcomes in those with atrial fibrillation: a systematic review protocol

Author: Timothy Lathlean, Don Kieu, Kyle B Franke, Nathan O'Callaghan, Mark A Boyd, and Rajiv Mahajan
Subjects: Heart Failure, Stroke, Atrial Fibrillation, Outcome Assessment, Health Care, Humans, General Medicine, Health Literacy, Systematic Reviews as Topic
Abstract: IntroductionAtrial fibrillation (AF) is associated with increased risk of stroke, heart failure and death. Health literacy, an aspect that falls within precision health, has been recognised as an important factor. We will be focusing on the impact of these interventions specifically to AF and its health outcomes.Methods and analysisThis protocol is informed by the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols. The results will be reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses to determine the impacts of health literacy interventions on AF outcomes. Searches will be carried out on databases including MEDLINE, EMBASE, Web of Science, CINAHL, Emcare, Cochrane Library and Google Scholar. Citations will be collected via Endnote 20, then into Covidence for duplicate removal, and article screening. Extraction will occur using a standardised extraction tool and studies will be synthesised using best evidence synthesis. Downs and Black’s checklist will be used for risk of bias and assessment of overall quality of evidence will use the Grading of Recommendations, Assessment, Development and Evaluation approach.Ethics and disseminationApproval from human research ethics committee is not required. Dissemination will occur in peer-reviewed journals and conference presentations.PROSPERO registration numberCRD42022304835.
Published: 2022

11. Regulatory coiled-coil domains promote head-to-head assemblies of AAA+ chaperones essential for tunable activity control

Author: Marta Carroni, Kamila B Franke, Michael Maurer, Jasmin Jäger, Ingo Hantke, Felix Gloge, Daniela Linder, Sebastian Gremer, Kürşad Turgay, Bernd Bukau, and Axel Mogk
Subjects: chaperone, heat shock protein, AAA+ protein, protein degradation, Medicine, Science, Biology (General), QH301-705.5
Abstract: Ring-forming AAA+ chaperones exert ATP-fueled substrate unfolding by threading through a central pore. This activity is potentially harmful requiring mechanisms for tight repression and substrate-specific activation. The AAA+ chaperone ClpC with the peptidase ClpP forms a bacterial protease essential to virulence and stress resistance. The adaptor MecA activates ClpC by targeting substrates and stimulating ClpC ATPase activity. We show how ClpC is repressed in its ground state by determining ClpC cryo-EM structures with and without MecA. ClpC forms large two-helical assemblies that associate via head-to-head contacts between coiled-coil middle domains (MDs). MecA converts this resting state to an active planar ring structure by binding to MD interaction sites. Loss of ClpC repression in MD mutants causes constitutive activation and severe cellular toxicity. These findings unravel an unexpected regulatory concept executed by coiled-coil MDs to tightly control AAA+ chaperone activity.
Published: 2017
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12. Characterization of electroless nickel-phosphorus plating for ultracold-neutron storage

Author: H. Akatsuka, T. Andalib, B. Bell, J. Berean-Dutcher, N. Bernier, C.P. Bidinosti, C. Cude-Woods, S.A. Currie, C.A. Davis, B. Franke, R. Gaur, P. Giampa, S. Hansen-Romu, M.T. Hassan, K. Hatanaka, T. Higuchi, C. Gibson, G. Ichikawa, I. Ide, S. Imajo, T.M. Ito, B. Jamieson, S. Kawasaki, M. Kitaguchi, W. Klassen, E. Korkmaz, F. Kuchler, M. Lang, M. Lavvaf, T. Lindner, M. Makela, J. Mammei, R. Mammei, J.W. Martin, R. Matsumiya, E. Miller, K. Mishima, T. Momose, S. Morawetz, C.L. Morris, H.J. Ong, C.M. O’Shaughnessy, M. Pereira-Wilson, R. Picker, F. Piermaier, E. Pierre, W. Schreyer, S. Sidhu, D. Stang, V. Tiepo, S. Vanbergen, R. Wang, D. Wong, and N. Yamamoto
Subjects: Nuclear and High Energy Physics, FOS: Physical sciences, Nuclear Experiment (nucl-ex), Instrumentation, Nuclear Experiment
Abstract: Electroless nickel plating is an established industrial process that provides a robust and relatively low-cost coating suitable for transporting and storing ultracold neutrons (UCN). Using roughness measurements and UCN-storage experiments we characterized UCN guides made from polished aluminum or stainless-steel tubes plated by several vendors. All electroless nickel platings were similarly suited for UCN storage with an average loss probability per wall bounce of $2.8\cdot10^{-4}$ to $4.1\cdot10^{-4}$ for energies between 90 neV and 190 neV, or a ratio of imaginary to real Fermi potential $\eta$ of $1.7\cdot10^{-4}$ to $3.3\cdot10^{-4}$. Measurements at different elevations indicate that the energy dependence of UCN losses is well described by the imaginary Fermi potential. Some special considerations are required to avoid an increase in surface roughness during the plating process and hence a reduction in UCN transmission. Increased roughness had only a minor impact on storage properties. Based on these findings we chose a vendor to plate the UCN-production vessel that will contain the superfluid-helium converter for the new TRIUMF UltraCold Advanced Neutron (TUCAN) source, achieving acceptable UCN-storage properties with ${\eta=3.5(5)\cdot10^{-4}}$., Comment: 8 pages, 7 figures
Published: 2022

13. The TRIUMF UltraCold Advanced Neutron Source

Author: R. Picker, Jeff Martin, Kichiji Hatanaka, B. Franke, and Shinsuke Kawasaki
Subjects: Condensed Matter::Quantum Gases, Nuclear physics, Physics, Nuclear and High Energy Physics, Astrophysics::High Energy Astrophysical Phenomena, Nuclear Theory, Fundamental physics, Measure (physics), Neutron source, Neutron, Physics::Atomic Physics, Nuclear Experiment
Abstract: A new ultracold neutron (UCN) source is being developed at TRIUMF for fundamental physics experiments. The TRIUMF UltraCold Advanced Neutron (TUCAN) Collaboration seeks to measure the neutron elect...
Published: 2021
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14. Elastomeric door seal analysis under aircraft cabin pressure

Author: V. Zatko, B. Franke Goularte, Alexander Lion, and Michael Johlitz
Subjects: Commercial software, Atmospheric pressure, Organic Chemistry, Boundary problem, Mechanical engineering, 02 engineering and technology, Plant Science, 021001 nanoscience & nanotechnology, Elastomer, Seal (mechanical), Finite element method, 020303 mechanical engineering & transports, 0203 mechanical engineering, Cabin pressurization, Compressibility, 0210 nano-technology
Abstract: Simple strategies are used to physically represent the cabin pressure acting on elastomeric seals for aircraft door applications. The relationships between rubber response, contact problem and air pressure are assumed as the initial step to understand the risks of air leakage during the early stages of a flight cycle. Through the finite element method, the non-linear boundary problem is investigated with the distinct contact response from two types of door interfaces. The options available within the ABAQUS commercial software are explored to model the seal as nearly incompressible, whereby the limitations are compared for each solution. In a qualitative approach, the simulations use the contact pressure distributions to define the pressure load for air leakage investigations on the door corners.
Published: 2021
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15. Whole exome sequencing in multi-incident families identifies novel candidate genes for multiple sclerosis

Author: J. Horjus, T. Banda, M. Heerings, M. Hakobjan, W. De Witte, D.J. Heersema, A.J. Jansen, E.M.M. Strijbis, B.A. de Jong, A.E.J. Slettenaar, E.M.P.E. Zeinstra, E.L.J. Hoogervorst, B. Franke, W. Kruijer, P.J. Jongen, L. Visser, and G. Poelmans
Abstract: Multiple sclerosis (MS) is a degenerative disease of the central nervous system in which auto-immunity-induced demyelination occurs. MS is thought to be caused by a complex interplay of environmental and genetic risk factors. While most genetic studies have focused on identifying common genetic variants for MS through genome-wide association studies, the objective of the present study was to identify rare genetic variants contributing to MS susceptibility. We used whole exome sequencing (WES) followed by co-segregation analyses in nine multi-incident families with 2 to 4 affected individuals. WES was performed in 31 family members with and without MS. After applying a suite of selection criteria, co-segregation analyses for a number of rare variants selected from the WES results were performed, adding 24 family members. This approach resulted in 12 exonic rare variants that showed acceptable co-segregation with MS within the nine families, implicating the genes MBP, PLK1, MECP2, MTMR7, TOX3, CPT1A, SORCS1, TRIM66, ITPR3, TTC28, CACNA1F, and PRAM1. Of these, three genes (MBP, MECP2, and CPT1A) have been previously reported as carrying MS-related rare variants. Six additional genes (MTMR7, TOX3, SORCS1, ITPR3, TTC28, and PRAM1) have also been implicated in MS through common genetic variants. The proteins encoded by all twelve genes containing rare variants interact in a molecular framework that points to biological processes involved in (de-/re-)myelination and auto-immunity. Our approach provides clues to possible molecular mechanisms underlying MS that should be further studied in cellular and/or animal models.
Published: 2022
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16. Processive extrusion of polypeptide loops by a Hsp100 disaggregase

Author: Sander J. Tans, Kamila B. Franke, Mario J. Avellaneda, Vanda Sunderlikova, Axel Mogk, and Bernd Bukau
Subjects: Folding (chemistry), 0303 health sciences, 03 medical and health sciences, 0302 clinical medicine, Multidisciplinary, Optical tweezers, Chemistry, Biophysics, Motor activity, Protein aggregation, CLPB, 030217 neurology & neurosurgery, 030304 developmental biology
Abstract: The ability to reverse protein aggregation is vital to cells1,2. Hsp100 disaggregases such as ClpB and Hsp104 are proposed to catalyse this reaction by translocating polypeptide loops through their central pore3,4. This model of disaggregation is appealing, as it could explain how polypeptides entangled within aggregates can be extracted and subsequently refolded with the assistance of Hsp704,5. However, the model is also controversial, as the necessary motor activity has not been identified6–8 and recent findings indicate non-processive mechanisms such as entropic pulling or Brownian ratcheting9,10. How loop formation would be accomplished is also obscure. Indeed, cryo-electron microscopy studies consistently show single polypeptide strands in the Hsp100 pore11,12. Here, by following individual ClpB–substrate complexes in real time, we unambiguously demonstrate processive translocation of looped polypeptides. We integrate optical tweezers with fluorescent-particle tracking to show that ClpB translocates both arms of the loop simultaneously and switches to single-arm translocation when encountering obstacles. ClpB is notably powerful and rapid; it exerts forces of more than 50 pN at speeds of more than 500 residues per second in bursts of up to 28 residues. Remarkably, substrates refold while exiting the pore, analogous to co-translational folding. Our findings have implications for protein-processing phenomena including ubiquitin-mediated remodelling by Cdc48 (or its mammalian orthologue p97)13 and degradation by the 26S proteasome14. A combination of optical tweezers and fluorescent-particle tracking is used to dissect the dynamics of the Hsp100 disaggregase ClpB, and show that the processive extrusion of polypeptide loops is the mechanistic basis of its activity.
Published: 2020
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17. Cardiac oxidative stress: a potential tool for risk stratification in cardiac sarcoidosis

Author: Kyle B Franke and Rajiv Mahajan
Subjects: Oxidative Stress, Sarcoidosis, Tachycardia, Ventricular, Humans, Cardiology and Cardiovascular Medicine, Aneurysm, Risk Assessment
Published: 2022

18. Superstructure optimization for sustainable design of an algae biorefinery

Author: Maryam Raeisi, Thien An Huynh, Meik B. Franke, Edwin Zondervan, and Sustainable Process Technology
Subjects: MINLP, superstructure, added-value products, Algae biorefinery, NLA
Abstract: In this study a superstructure of an algae biorefinery to produce added value products (pigments, omega-3, glycerol, biodiesel, biogas, and fertilizer) from microalgae is developed. From the superstructure optimization follows a cost optimal production pathway that consists of an open pond, sedimentation and flotation, flocculation/ centrifugation without a dryer, hydrothermal liquefaction, organic solvent pigment extraction, N-butanol lipid extraction, lipid production, and anaerobic digestion. The profits of the algae biorefinery depend on the types of wastewaters. 107 million Euros income can be earned annually using 0.2 million tons of influent wastewater. The total profit of an algae biorefinery that uses influent wastewater as feedstock is approximately two times higher than the wastewater of wheat straw biorefinery. 63 million Euros income can be earned annually using 0.6 million tons of influent wastewater. Furthermore, the total profits of algae biorefinery in each season are calculated by using real data of sunlight periods of the Netherlands. Summer is the best season with more than 36 and 22 million Euros profits for algae biorefineries when using influent wastewater and wastewater of wheat straw biorefinery, respectively. Calculating total profits of algae biorefinery by considering fix value for durations of sunlight has more than 30% error.
Published: 2022

19. Maternal gestational weight gain and offspring’s neurodevelopmental outcomes: a systematic review and meta-analysis

Author: D. Wu, Y. Li, L. Chen, M. Klein, B. Franke, J. Chen, and J. Buitelaar
Published: 2023
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20. A possible protective effect of sleep consistency against genetic liabilities for mental health problems in youth

Author: Y. Shi, N. Roth Mota, D. Demontis, A. Børglum, B. Franke, and E. Sprooten
Published: 2023
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21. Dynamic Modeling and Control of a Simulated Carbon Capture Process for Sustainable Power-to-X

Author: Mahmoud Mostafa, Christopher Varela, Meik B. Franke, and Edwin Zondervan
Subjects: Technology, QH301-705.5, Aspen Plus®, Physics, QC1-999, Carbon-Capture, renewables, Engineering (General). Civil engineering (General), dynamic model, simulation, Chemistry, amine, TA1-2040, Biology (General), QD1-999
Abstract: The goal of this study is to develop a dynamic model for a Carbon Capture (CC) process that can be integrated with a water electrolysis facility. The possibility of operating the post-combustion CC plant dynamically is investigated. The final model successfully tracks the parallel hydrogen production, providing the stoichiometric required CO2 stream for the subsequent methanol reactor. A dynamic model is used to configure controllers and to test the unit performance and stream conditions for various set points. Through the transient operation, the required feed gas is provided while optimizing the solvent and energy requirements. It is found that the slowest acting stage is the reboiler with a time constant of 3.8 h. Other process variables stabilize much quicker, requiring only a few minutes to reach steady-state conditions. The hydrogen-tracking scenario shows that the carbon capture plant can successfully operate under varying conditions with a maximum CO2 output increase of 7% of the minimum flowrate in the representative 24 h simulation time. The output CO2 stream is maintained at the desired &gt, 98% purity, 25 °C temperature, and 1.85 bar pressure, which allows to successfully perform hydrogen tracking operations.
Published: 2021
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22. P.0633 Epigenome-wide DNA methylation in externalizing behaviours: a review and meta-analysis

Author: M. Meijer, T. Zayats, A. Starnawska, T. Kranz, M. Hoogman, J. Buitelaar, A. Reif, M. Ribasés, J. Haavik, B. Franke, C. Sandi, and M. Klein
Subjects: Pharmacology, Psychiatry and Mental health, Neurology, Pharmacology (medical), Neurology (clinical), Biological Psychiatry
Published: 2021
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23. P.0331 Neural correlates of reactive aggression in adult attention-deficit/hyperactivity disorder

Author: B. Jakobi, M. Hoogman, A. Arias-Vasquez, D. Van Rooij, P. Vlaming, and B. Franke
Subjects: Pharmacology, Psychiatry and Mental health, Neurology, Pharmacology (medical), Neurology (clinical), Biological Psychiatry
Published: 2021
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24. Transcriptomic Analysis of Resistant and Susceptible Responses in a New Model Root-Knot Nematode Infection System Using Solanum torvum and Meloidogyne arenaria

Author: Kazuki Sato, Taketo Uehara, Julia Holbein, Yuko Sasaki-Sekimoto, Pamela Gan, Takahiro Bino, Katsushi Yamaguchi, Yasunori Ichihashi, Noriko Maki, Shuji Shigenobu, Hiroyuki Ohta, Rochus B. Franke, Shahid Siddique, Florian M. W. Grundler, Takamasa Suzuki, Yasuhiro Kadota, and Ken Shirasu
Subjects: Chalcone synthase, Turkey berry, Plant Biology, Plant Science, Biology, Microbiology, SB1-1110, comparative transcriptomics, lignin deposition, Genetics, Meloidogyne incognita, medicine, 2.1 Biological and endogenous factors, Root-knot nematode, Aetiology, Solanum torvum, Cell wall modification, Original Research, plant-parasitic nematode, food and beverages, Plant culture, biology.organism_classification, medicine.disease, Infectious Diseases, Nematode infection, Meloidogyne arenaria, biology.protein, Spermidine synthase, plant immunity, Infection
Abstract: Root-knot nematodes (RKNs) are among the most devastating pests in agriculture. Solanum torvum Sw. (turkey berry) has been used as a rootstock for eggplant (aubergine) cultivation because of its resistance to RKNs, including Meloidogyne incognita and M. arenaria. We previously found that a pathotype of M. arenaria, A2-J, is able to infect and propagate in S. torvum. In vitro infection assays showed that S. torvum induces the accumulation of brown pigments during avirulent pathotype A2-O infection, but not during virulent A2-J infection. This experimental system is advantageous because resistant and susceptible responses can be distinguished within a few days, and because a single plant genome can yield information about both resistant and susceptible responses. Comparative RNA-sequencing analysis of S. torvum inoculated with A2-J and A2-O at early stages of infection was used to parse the specific resistance and susceptible responses. Infection with A2-J did not induce statistically significant changes in gene expression within one day post-inoculation (DPI), but afterward, A2-J specifically induced the expression of chalcone synthase, spermidine synthase, and genes related to cell wall modification and transmembrane transport. Infection with A2-O rapidly induced the expression of genes encoding class III peroxidases, sesquiterpene synthases, and fatty acid desaturases at 1 DPI, followed by genes involved in defense, hormone signaling, and the biosynthesis of lignin at 3 DPI. Both isolates induced the expression of suberin biosynthetic genes, which may be triggered by wounding during nematode infection. Histochemical analysis revealed that A2-O, but not A2-J, induced lignin accumulation at the root tip, suggesting that physical reinforcement of cell walls with lignin is an important defense response against nematodes. The S. torvum-RKN system can provide a molecular basis for understanding plant-nematode interactions.
Published: 2021
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25. Robotic endoscopic transforaminal lumbar interbody fusion: A single institution case series

Author: B.F. Saway, C. Cunningham, M. Pereira, M. Sowlat, S.S. Elawady, G. Porto, J. Barley, Nathan Nordmann, and B. Frankel
Subjects: Endoscopic, Robotic, TLIF, Spine, MIS, Surgery, RD1-811, Neurology. Diseases of the nervous system, RC346-429
Abstract: Background: Robotic-assisted, endoscopic transforaminal lumbar interbody fusion (RE-TLIF) is a promising, minimally invasive surgical option for degenerative lumbar spondylosis/spondylolisthesis; however, outcomes data and efficacy are limited, especially in multilevel disease. Here, we present the first reported series of patients that underwent either single or multilevel RE-TLIF. Methods: A retrospective review was performed on 23 consecutive patients who underwent a single level or multilevel RE-TLIF by a single surgeon. Variables included demographics, perioperative results, pain scores, and functional outcome scores. Results: Eighteen patients (78.3 %) underwent single level RE-TLIF and 5 patients (21.7 %) underwent multilevel RE-TLIF. The median reduction of visual analog scale (VAS) for low back pain (LBP) of all subjects was 6 (IQR = 4.5, 6.5) with no significant difference between single level and multilevel RE-TLIF (p = 0.565). The median reduction of VAS for leg pain of all subjects 7 (IQR = 6, 8) with no significant difference between single level and multilevel RE-TLIF (p = 0.702). Median blood loss was 25 cc (IQR = 25, 25) and 50 cc (IQR = 25, 100) for single and multilevel RE-TLIF, respectively (p = 0.025), whereas median length of stay was 1 (IQR = 1, 1; mean = 1.0 ± 00.18) days and 1 (IQR = 1, 2; mean = 1.4 ± 00.54) days, respectively (p = 0.042). One major complication was observed requiring reoperation for demineralized bone matrix migration resulting in an L5 radiculopathy. Conclusions: Single and multi-level RE-TLIF appears to be a safe and efficacious approach with comparable outcomes to open and other minimally invasive approaches. Additionally, we observed favorable accuracy in robot-assisted pedicle screw, endoscope, and interbody device placement.
Published: 2024
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26. Life Satisfaction in Autism

Author: Kathleen B. Franke
Published: 2021
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27. Dissociation Extraction: Historic Perspective, New Application Fields and Shortcut Calculations for Conceptual Process Design

Author: Meik B. Franke and Boelo Schuur
Published: 2021
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28. Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study

Author: Kirmeier E. a, Eriksson L. I. c, Lewald H. a, Jonsson Fagerlund, M. c Hoeft, A. f Hollmann, M. g Meistelman, C. e Hunter, J. M. d Ulm, K. b Blobner, M. aEmail Author, Abad Gurumeta, A. Abernethy, C. Abigail, P. Achaibar, K. Adam, E. Afshari, Agudelo Montoya, M. E. Akgün, F. N. Aletti, G. Alkış, N. Allan, K. Allan, A. Allaouchiche, B. Allcock, C. Almasy, E. Amey, I. Amigoni, M. Andersen, E. Andersson, P. Anipchenko, N. Antunes, P. Armstrong, E. Aslam, T. N. Aslin, B. Assunção, J. P. Ausserer, J. Avvai, M. Awad, Ayas Montero, B. Ayuso, M. Azevedo, P. Badarau, V. Badescu, Baiardo Redaelli, M. Baird, C. Baird, Y. Baker, T. Balaji, P. Bălan, C. Balandin, A. Balescu-Arion, C. Baliuliene, Baltasar Isabel, J. Baluch, S. N. Bandrabur, D. Bankewitz, C. Barber, K. Barbera, F. Barcraft-Barnes, H. Barletti, V. Barnett, G. Baron, K. Barros, A. Barsan, V. Bartlett, P. Batistaki, C. Baumgarten, G. Baytas, V. Beauchamp, Becerra Cayetano, I. A. Bell, S. Bellandi, M. Belletti, Belmonte Cuenca, J. Benitez-Cano, A. Beretta, L. Berger, M. Bergmann, N. Bergmark, Bermudez Lopez, M. Bernotaite, M. Beurskens, C. Bidd, H. Bifulco, F. Bignami, E. Bilic, A. Bilskiene, D. Bischoff, P. Bishop, L. Bjonness, T. Blaylock, H. Blethyn, K. Blincoe, T. Blokhin, I. Blunt, N. Boer, C. Bois, G. Bonicolini, E. Booth, J. Borecka-Kedzierska, M. Borstnar, K. Borys, M. Boselli, E. Bouvet, L. Bouwman, A. Bowen, L. Bowrey, S. Boxall, L. Božić, T. Bradley, T. Branco, T. Brazzi, L. Brazzoni, M. Brear, T. Brogly, N. Brohi, F. Broms, J. Bubliauskas, A. Bucolo, G. E. Buerkle, H. Buggy, D. Buhre, W. Bukauskas, T. Butturini, F. Byttner, Cabrera Díaz, I. Calderon, A. Calhau, R. Callejo, A. Cammu, G. Campesato, M. Can, Ö. S. Candeias, M. Cantor, A. Carise, E. Carmona, C. Carreteiro, J. Carrieri, C. Carter, A. Casal, M. Casanova, I. Cascella, M. Casero, L. M. Casiraghi, G. M. Castelo-Branco, Castro Arranz, C. Cernea, D. D. Cervantes, J. Chandler, B. Charnock, R. Chatzimicali, A. 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L., Estenes S., Ewaldsson C., Farid N., Featherstone J., Febres D., Fedorov S., Feggeler J., Feijten P., Fellmann T., Fernandez Candil, Fernandez Castineira, Fernández Castineira, J. Fernando, A. Ferrando, C. Ferreira, L. Ferreira, P. Feyling, A. Filipescu, D. Fleischer, A. Floris, L. Foerster, U. Fox, B. Franke, U. Frasca, D. Frey, C. Frost, V. Fullin, G. Fumagalli, J. Furneval, J. Fusari, M. Gallacher, S. Galushka, S. Gambale, G. Gambino, I. Garcia-Perez, M. L. Garg, S. Garlak, J. Gavranovic, Z. Gavrilov, R. Gaynor, Gecaj Gashi, A. Georghiou, M. Gerjevic, B. Gferer, G. Giarratano, A. Gibson, A. Gievski, V. Giles, J. Gillberg, L. Gilowska, Gilsanz Rodriguez, F. Gioia, A. Giovannoni, C. Girotra, V. Gkinas, D. Gkiokas, G. Godoroja, D. Goebel, U. Goel, V. Gonzalez, M. Goranovic, T. Gornik-Wlaszczuk, E. Gosavi, S. Gottfridsson, P. Gottschalk, A. Granell, M. Granstrom, A. Grassetto, A. Greenwood, A. Grigoras, I. Grintescu, I. Gritsan, A. Gritsan, G. Grynyuk, A. Guadagnin, G. M. 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Kadaoui, S. -D., Kanski A., Karadag S., Karbonskiene A., Karjagin J., Kasnik D., Katanolli F., Katsika E., Kaufmann K., Keane H., Kelly M., Kent M., Keraitiene G., Khudhur A., Khuenl-Brady K., Kidd L., King S., Kirchgäßner K., Klancir T., Klucniks A., Knotzer J., Knowlden P., Koers L., Kompan J., Koneti K. K., Kooij F., Koolen E., Koopman - van Gemert, A. W. M. M. Kopp, K. Korfiotis, D. Korolkov, O. Kosinová, M. Köstenberger, M. Kotzinger, O. Kovačević, M. Kranke, P. Kranke, E. Kraus, C. Kraus, S. Kubitzek, C. Kucharski, R. Kucukguclu, S. Kudrashou, A. Kumar, V. Kummen, L. Kunit, C. Kushakovsky, V. Kuvaki, B. Kuzmanovska, B. Kyttari, A. Landoni, G. Lau, G. Lazarev, K. Legett, S. Legrottaglie, A. M. Leonardi, S. Leong, M. Lercher, H. Leuvrey, M. Leva, B. Levstek, M. Limb, J. Lindholm, E. Linton, F. Liperi, C. Lipski, F. Lirk, P. Lisi, A. Lišková, Lluch Oltra, A. Loganathan, V. Lombardi, S. Lopez, Lopez Rodríguez, M. Lorenzini, L. Lowicka, M. Lugovoy, A. Luippold, M. Lumb, A. Macas, A. 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M., Leonardi, S., Leong, M., Lercher, H., Leuvrey, M., Leva, B., Levstek, M., Limb, J., Lindholm, E., Linton, F., Liperi, C., Lipski, F., Lirk, P., Lisi, A., Lišková, Lluch, Oltra, A., Loganathan, V., Lombardi, S., Lopez, Lopez, Rodríguez, M., Lorenzini, L., Lowicka, M., Lugovoy, A., Luippold, M., Lumb, A., Maca, A., Macgregor, M., Machado, H., Maciariello, M., Madeira, I., Maitan, S., Majewski, J., Maldini, B., Malewski, G., Manfredini, L., Männer, O., Marchand, B., Marcu, A., Margalef, J., Margarson, M., Marinheiro, L., Markic, Markovic, Bozic, J., Marrazzo, F., Martin, Martin, Ayuso, M., Martinez, E., Martino, E. A., Martinson, V., Marusic-Gaser, K., Mascarenha, C., Mathi, C., Matsota, P., Mavrommati, Mazul, Sunko, B., Mccourt, K., Mcgill, N., Mckee, R., Meço, B. C., Meier, S., Melbourne, S., Melbybråthen, G., Meli, A., Melia, A., Melotti, R. M., Menga, M. 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Suzana, Parfeni, Alexandru, Pasin, Laura, Passey, Samuel, Pastor, Ernesto, Patch, Sarah, Patil, Andan, Paunescu, Marilena-Alina, Pehboeck, Daniel, Pereira, Manuela, Pereira, Carla, Perez Caballero, Paula, Pérez García, Aníbal, Pérez Soto, Antonia, Perez Tejero, Gisela, Perez-Cerda, Francisco, Pesenti, Antonio, Petta, Rocco, Philippe, Simon, Pickering, David, Pico Veloso, Jandro, Pina, Pedro, Pinho-Oliveira, Vítor, Pinol, Santiago, Pinto, Rita, Pistidda, Laura, Pitterle, Manuela, Piwowarczyk, Paweł, Plotnikova, Olga, Pohl, Holger, Poldermann, Jorinde, Polkovicová, Lucia, Pompei, Livia, Popescu, Mihai, Popović, Radmila, Pota, Vincenzo, Potocnik, Miriam, Potręć, Beata, Potter, Alison, Pramod, Nalwaya, Prchalova, Martina, Preckel, Benedikt, Pugh, Richard, Pulletz, Mark, Radoeshki, Aleksandar, Rafi, Amir, Ragazzi, Riccardo, Raineri Santi, Maurizio, Rajamanickam, Tamiselvan, Rajput, Zahra, Ramachandran, Rajeskar, Ramasamy, Radhika, Ramessur, Suneil, Rao, Roshan, Rasmussen, Ander, Rato, André, Razaque, Usman, Real Navacerrada, M. Isabel, Reavley, Caroline, Reid, Jame, Reschreiter, Henrik, Rial, Erick, Ribas Carrasco, Patricia, Ribeiro, Sandy, Rich, Nathalie, Richardson, Lydia, Rimaitis, Kestuti, Rimaitis, Mariu, Ringvold, Else-Marie, Ripke, Fabian, Ristescu, Irina, Ritchie, Keith, Ródenas, Frederic, Rodrigues, Patrícia, Rogers, Emma, Rogerson, David, Romagnoli, Stefano, Romero, Esther, Rondovic, Goran, Rose, Bernd Oliver, Roth, Winfried, Rotter, Marie-Therese, Rousseau, Guy, Rudjord, Ander, Rueffert, Henrik, Rundgren, Malin, Rupprecht, Korbinian, Rushton, Andrew, Russotto, Vincenzo, Rypulak, Elżbieta, Ryszka, Maciej, Sà, Jacinta, Sà Couto, Paula, Saby, Sandrine, Sagic, Jelena, Saleh, Omar, Sales, Gabriele, Sánchez Sánchez, Yván, Sanghera, Sumayer, Şanli Karip, Ceren, Santiveri Papiol, Francisco Javier, Santos, Sofia, Sarno, Stephen, Saul, Daniel, Saunders, David, Savic, Nenad, Scalco, Loïc, Scanlon, Deborah, Schaller, Stefan, Schax, Christoph, Scheffer, Gert Jan, Schening, Anna, Schiavone, Vincenzo, Schmidt-Ehrenberg, Florian, Schmidt-Mutter, Catherine, Schönberg, Christina, Schopflin, Christian, Schreiber, Jan-Uwe, Schultz, Marcu, Schurig, Marlen, Scott, Carmen, Sebestian, Siby, Sehgal, Selena, Sem, Victoria, Semenas, Egidiju, Serafini, Elena, Serchan, Pashalitsa, Shields, Martin, Shobha, Ramakrishnan, Shosholcheva, Mirjana, Siamansour, Tanja, Siddaiah, Narendra, Siddiqi, Khalid, Sinclair, Rhona, Singh, Permendra, Singh, Rajendra, Sinha, Aneeta, Sinha, Ashok, Skinner, Amanda, Smee, Elizabeth, Smekalova, Olga, Smith, Neil, Smith, Thoma, Smitz, Carine, Smole, Daniel, Sojčić, Nataša, Soler Pedrola, Maria, Somanath, Sameer, Sonksen, Julian, Sorella, Maria Christina, Sörmus, Alar, Soro, Marina, Soto, Carmen, Spada, Anna, Spadaro, Savino, Spaeth, Johanne, Sparr, Harald, Spielmann, Annika, Spindler-Vesel, Alenka, Stamelos, Matthaio, Stancombe L, Liucia, Stanculescu, Andreea, Standl, Thoma, Standley, Tom, Stanek, Ondrej, Stanisavljević, Snežana, Starczewska, Malgorzata, Stäuble, Christiane, Steen, Julie, Stefan, Oana Maria, Stell, Elizabeth, Stera, Caterina, Stevens, Marku, Stoerckel, Marlène, Stošić, Biljana, Stourac, Petr, Stroumpoulis, Konstantino, Struck, Rafael, Suarez de la Rica, Alejandro, Sultanpori, Altaf, Sundara Rajan, Rajinikanth, Suying, Ong, Svensen, Christer, Swan, Louise, Syrogianni, Paulina, Sysiak, Justyna, Szederjesi, Jano, Taddei, Stefania, Tan Hao, Ern, Tanou, Virginia, Tarabová, Katarina, Tardaguila Sancho, Paula, Tarroso, Maria, Tartaglione, Marco, Taylor, Emma, Tbaily, Lee, Telford, Richard, Terenzoni, Massimo, Theodoraki, Kassiani, Thornley, Helen, Tiganiuc, Liviu, Toim, Hardo, Tomescu, Dana, Tommasino, Concezione, Toni, Jessica, Toninelli, Arturo, Toretti, Ilaria, Townley, Stephen, Trepenaitis, Dariu, Trethowan, Brian, Tsaousi, Georgia, Tsiftsi, Aikaterini, Tudor, Adrada, Turan, Güldem, Turhan, Sanem Çakar, Unic-Stojanovic, Dragana, Unterbuchner, Christoph, Unzueta, Carmen, Uranjek, Jasna, Ursic, Tomaz, Vaida, Simona, Valldeperas Ferrer, Silvia, Valldeperas Hernandez, Maria Inmaculada, Valsamidis, Dimitri, Van Beek, Rienk, Van dasselaer, Nick, Van Der Beek, Tim, Van Duivenvoorde, Yoni, van Klei, Wilton A., Van Poorter, Fran, Van Zaane, Ba, Van Zundert, Tom, Van Zyl, Rebekka, Vargas Munoz, Ana Milena, Varsani, Nimu, Vasconcelos, Pedro, Vassilakis, Georgio, Vecchiatini, Tommaso, Vecera, Lubomir, Vercauteren, Marcel, Verdouw, Ba, Verheyen, Veerle, Verri, Marco, Vicari Sottosanti, Luigi Giancarlo, Vico, Manuel, Vidal Mitjans, Patricia, Vilardi, Anna, Vissicchio, Daniela, Vitale, Giovanni, Vitković, Bibiana, Vizcaychipi, Marcela Paola, Voicu, Alexandra, Voje, Minca, Volfová, Ivana, Volta, Carlo Alberto, Von Lutterotti, Theresa, von Tiesenhausen, Anna, Vrecic-Slabe, Simona, Vukcevic, Dejan, Vukovic, Rade, Vullo, P. Agostina, Wade, Andrew, Wallberg, Hanna, Wallden, Jakob, Wallner, Johann, Walther Sturesson, Louise, Watson, Davina, Weber, Stefan, Wegiel Leskiewiq, Anna, Weller, Debbie, Wensing, Carine, Werkmann, Marku, Westberg, Henrik, Wikström, Erik, Williams, Benedict, Wilson, Robin, Wirth, Steffen, Wittmann, Maria, Wood, Laura, Wright, Stella, Zachoval, Christian, Zambon, Massimo, Zampieri, Silvia, Zampone, Salvatore, Zangrillo, Alberto, Zani, Gianluca, Zavackiene, Asta, Zieglerder, Raphael, Zonneveldt, Harry, Zsisku, Lajo, Zucker, Tom-Philipp, Żukowski, Maciej, Zuleika, Mehrun, and Zupanĕiĕ, Darja
Subjects: Pulmonary and Respiratory Medicine, pulmonary complications, muscle relaxants, Post-anaesthesia complications, Neuromuscular Blockade, pulmonary complication, muscle relaxant, neuromuscular block, postoperative pulmonary complication, business.industry, Retrospective cohort study, post-operative pulmonary complications, Neuromuscular monitoring, Neuromuscular Blocking Agents, Sugammadex, NO, Anaesthesia, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Anesthesia, Medicine, General anaesthesia, Neuromuscular Agents, 030212 general & internal medicine, MED/41 - ANESTESIOLOGIA, Prospective cohort study, business, medicine.drug
Abstract: Background: Results from retrospective studies suggest that use of neuromuscular blocking agents during general anaesthesia might be linked to postoperative pulmonary complications. We therefore aimed to assess whether the use of neuromuscular blocking agents is associated with postoperative pulmonary complications. Methods: We did a multicentre, prospective observational cohort study. Patients were recruited from 211 hospitals in 28 European countries. We included patients (aged ≥18 years) who received general anaesthesia for any in-hospital procedure except cardiac surgery. Patient characteristics, surgical and anaesthetic details, and chart review at discharge were prospectively collected over 2 weeks. Additionally, each patient underwent postoperative physical examination within 3 days of surgery to check for adverse pulmonary events. The study outcome was the incidence of postoperative pulmonary complications from the end of surgery up to postoperative day 28. Logistic regression analyses were adjusted for surgical factors and patients' preoperative physical status, providing adjusted odds ratios (ORadj) and adjusted absolute risk reduction (ARRadj). This study is registered with ClinicalTrials.gov, number NCT01865513. Findings: Between June 16, 2014, and April 29, 2015, data from 22 803 patients were collected. The use of neuromuscular blocking agents was associated with an increased incidence of postoperative pulmonary complications in patients who had undergone general anaesthesia (1658 [7·6%] of 21 694); ORadj 1·86, 95% CI 1·53–2·26; ARRadj −4·4%, 95% CI −5·5 to −3·2). Only 2·3% of high-risk surgical patients and those with adverse respiratory profiles were anaesthetised without neuromuscular blocking agents. The use of neuromuscular monitoring (ORadj 1·31, 95% CI 1·15–1·49; ARRadj −2·6%, 95% CI −3·9 to −1·4) and the administration of reversal agents (1·23, 1·07–1·41; −1·9%, −3·2 to −0·7) were not associated with a decreased risk of postoperative pulmonary complications. Neither the choice of sugammadex instead of neostigmine for reversal (ORadj 1·03, 95% CI 0·85–1·25; ARRadj −0·3%, 95% CI −2·4 to 1·5) nor extubation at a train-of-four ratio of 0·9 or more (1·03, 0·82–1·31; −0·4%, −3·5 to 2·2) was associated with better pulmonary outcomes. Interpretation: We showed that the use of neuromuscular blocking drugs in general anaesthesia is associated with an increased risk of postoperative pulmonary complications. Anaesthetists must balance the potential benefits of neuromuscular blockade against the increased risk of postoperative pulmonary complications. Funding: European Society of Anaesthesiology.
Published: 2019
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29. Measurement of the permanent electric dipole moment of the neutron

Author: I. Rienäcker, V. Hélaine, M. Daum, Prajwal Mohanmurthy, J. A. Thorne, J. Krempel, J. Zenner, S. Roccia, Jacek Zejma, Martin Burghoff, E. Wursten, N. J. Ayres, G. Wyszynski, W. C. Griffith, G. Ban, M. G. D. van der Grinten, R. Virot, C. Abel, Bernhard Lauss, Florian M. Piegsa, P. N. Prashanth, P. J. Chiu, Christopher Crawford, Nathal Severijns, Oscar Naviliat-Cuncic, Antoine Weis, S. Afach, Guillaume Pignol, M. Kuźniak, Jens-Uwe Voigt, R. Tavakoli Dinani, A. Knecht, C. Plonka-Spehr, Geza Zsigmond, D. Rozpedzik, Z. Hodge, A. Kraft, Martin Fertl, P. Flaux, Reinhold Henneck, P. A. Koss, M. Horras, G. Rogel, Y. Kermaidic, E. Pierre, Paul E. Knowles, S. Komposch, A. Kozela, Georg Bison, M. Rawlik, D. Rebreyend, E. Chanel, L. Ferraris-Bouchez, Z. Chowdhuri, D. Ries, P. Geltenbort, Klaus Kirch, L. Hayen, Zoran D. Grujić, K. Green, Y. Lemière, Werner Heil, G. Quéméner, P. Schmidt-Wellenburg, S. N. Ivanov, C.A. Baker, H. C. Koch, P. Iaydjiev, V. Bondar, T. Lefort, B. Clement, Malgorzata Kasprzak, A. Mtchedlishvili, Philip Harris, Allard Schnabel, M. Musgrave, S. Emmenegger, D. Shiers, D. Pais, N. Hild, A. Fratangelo, Kazimierz Bodek, B. Franke, A. Leredde, Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Institut Laue-Langevin (ILL), ILL, nEDM, Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)
Subjects: Physics - Instrumentation and Detectors, Magnetometer, FOS: Physical sciences, General Physics and Astronomy, 01 natural sciences, Measure (mathematics), S017EDM, law.invention, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), statistical analysis, law, cesium, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], time reversal: invariance, Statistical analysis, Neutron, Nuclear Physics - Experiment, Physics::Atomic Physics, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Nuclear Experiment (nucl-ex), Detectors and Experimental Techniques, 010306 general physics, Nuclear Experiment, Physics, n: electric moment, Instrumentation and Detectors (physics.ins-det), Cesium vapor, Magnetic field, Electric dipole moment, Automatic Keywords, Ultracold neutrons, Elementary Particles and Fields, history, Atomic physics, time reversal: violation, magnetic field: oscillation, Particle Physics - Experiment
Abstract: We present the result of an experiment to measure the electric dipole moment (EDM) of the neutron at the Paul Scherrer Institute using Ramsey’s method of separated oscillating magnetic fields with ultracold neutrons. Our measurement stands in the long history of EDM experiments probing physics violating time-reversal invariance. The salient features of this experiment were the use of a 199Hg comagnetometer and an array of optically pumped cesium vapor magnetometers to cancel and correct for magnetic-field changes. The statistical analysis was performed on blinded datasets by two separate groups, while the estimation of systematic effects profited from an unprecedented knowledge of the magnetic field. The measured value of the neutron EDM is dn=(0.0±1.1stat±0.2sys)×10−26 e.cm., Physical Review Letters, 124 (8), ISSN:0031-9007, ISSN:1079-7114
Published: 2020
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30. WILDLIFE MONITORING REPORT FOR CORCOVADO NATIONAL PARK, COSTA RICA -2019

Author: E R Olson, J B Franke, V Chevalier, J Kolasch, G Saborío-R, A Azofeifa, E Olmos, and W Montes
Published: 2020
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31. Collaboration: An Essential Ingredient for Effective School Behavioral Health

Author: June Greenlaw, John Terry, Tristan Collier, and Kathleen B. Franke
Subjects: Medical education, media_common.quotation_subject, General partnership, Perception, education, Motivational interviewing, Stigma (botany), Empathy, Family engagement, Psychology, Mental health, media_common, Healthcare system
Abstract: Collaboration between schools, families, communities, and youth-serving organizations is essential for addressing mental health challenges in youth. Creating centralized and engaged teams to improve coordination of care can ultimately improve student outcomes. Themes related to improving partnerships and collaboration in school behavioral health include increasing awareness of mental health needs of children and youth, strengthening the capacity of programs to meet these needs, reducing stigma related to mental health, increasing actions that communicate empathy and understanding of these needs, as well as increasing family engagement in care. This includes understanding the prevalence of mental health concerns in youth and skills needed to address these issues in schools, as well as understanding barriers to receiving care. Recognition of families’ mental health perceptions can help to facilitate care and reduce barriers that prevent families from participating in the child’s mental health services. School behavioral health systems support the level of collaboration needed to address these themes and serve youth with mental health concerns appropriately.
Published: 2020
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32. A regulator gene with an impact: RBFOX1 and its role in neuropsychiatric disorders

Author: A.Y. Yotova, A. O’Leary, N. Fernàndez-Castillo, G. Gan, E. Antón-Galindo, J. Cabana-Domínguez, T. Kranz, L. Grünewald, N. Roth Mota, B. Franke, B. Straube, U. Lueken, H. Weber, P. Pauli, F. Freudenberg, B. Cormand, D.A. Slattery, and A. Reif
Published: 2022
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33. Multi-polygenic scores in a naturalistic psychiatric cohort: from disorder-specific to transdiagnostic perspectives

Author: Y. Shi, E. Sprooten, P. Mulders, J. Vrijsen, P. van Eijndhoven, I. Tendolkar, B. Franke, and N. Roth Mota
Published: 2022
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34. The role of the gut-microbiome-brain-axis for emotion dysregulation in adult ADHD

Author: B. Jakobi, M. Hoogman, A. Arias-Vasquez, B. Franke, and D. van Rooij
Published: 2022
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35. SHINE transcription factors act redundantly to pattern the archetypal surface of Arabidopsis flower organs.

Author: Jian Xin Shi, Sergey Malitsky, Sheron De Oliveira, Caroline Branigan, Rochus B Franke, Lukas Schreiber, and Asaph Aharoni
Subjects: Genetics, QH426-470
Abstract: Floral organs display tremendous variation in their exterior that is essential for organogenesis and the interaction with the environment. This diversity in surface characteristics is largely dependent on the composition and structure of their coating cuticular layer. To date, mechanisms of flower organ initiation and identity have been studied extensively, while little is known regarding the regulation of flower organs surface formation, cuticle composition, and its developmental significance. Using a synthetic microRNA approach to simultaneously silence the three SHINE (SHN) clade members, we revealed that these transcription factors act redundantly to shape the surface and morphology of Arabidopsis flowers. It appears that SHNs regulate floral organs' epidermal cell elongation and decoration with nanoridges, particularly in petals. Reduced activity of SHN transcription factors results in floral organs' fusion and earlier abscission that is accompanied by a decrease in cutin load and modified cell wall properties. SHN transcription factors possess target genes within four cutin- and suberin-associated protein families including, CYP86A cytochrome P450s, fatty acyl-CoA reductases, GSDL-motif lipases, and BODYGUARD1-like proteins. The results suggest that alongside controlling cuticular lipids metabolism, SHNs act to modify the epidermis cell wall through altering pectin metabolism and structural proteins. We also provide evidence that surface formation in petals and other floral organs during their growth and elongation or in abscission and dehiscence through SHNs is partially mediated by gibberellin and the DELLA signaling cascade. This study therefore demonstrates the need for a defined composition and structure of the cuticle and cell wall in order to form the archetypal features of floral organs surfaces and control their cell-to-cell separation processes. Furthermore, it will promote future investigation into the relation between the regulation of organ surface patterning and the broader control of flower development and biological functions.
Published: 2011
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36. Considerações sobre a propagação e o uso ornamental de plantas raras ou ameaçadas de extinção no Rio Grande do Sul, Brasil.

Author: Cecília Maciel Barroso, Gilmar Nicolau Klein, Ingrid B. I. de Barros, Lúcia B. Franke, and Andréia Becker Delwing
Subjects: Plant culture, SB1-1110
Abstract: A extração de plantas silvestres para a comercialização, além de ser atividade ilegal e não sustentada, é considerada uma das principais causas de sua extinção. A introdução de plantas exóticas é considerada a segunda maior ameaça à conservação da biodiversidade mundial. Esta se voltou para o comércio de plantas ornamentais nos últimos tempos, e deu ocasião a invasões de muitas dessas plantas. A utilização de plantas nativas para ornamentação diminui consideravelmente os riscos de contaminação biológica quando estas escapam das áreas de cultivo. Sua propagação em viveiros legalizados diminui a pressão por coletas na natureza. Porém, quanto ao uso de plantas raras ou ameaçadas de extinção na ornamentação, questões como a pressão de coleta, a variabilidade genética intra e interespecífica e a seleção de variedades devem ser consideradas. Este artigo aborda estas e outras questões, como o conceito de espécie nativa, a propagação de espécies ameaçadas de extinção e a proliferação de determinadas variedades em detrimento de outras, que são pertinentes àqueles que desejam promover o uso de plantas nativas na ornamentação e no paisagismo.
Published: 2007
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37. S.16.02 Intellectual disability-related genes increase ADHD risk and locomotor activity in Drosophila melanogaster

Author: M. Klein, E. Singgih, A. Van Rens, D. Demontis, A. Borglum, N. Roth Mota, A. Castells-Nobau, L. Kiemeney, H. Brunner, A. Arias-Vasquez, A. Schenck, M. Van der Voet, and B. Franke
Subjects: Pharmacology, Psychiatry and Mental health, Neurology, Pharmacology (medical), Neurology (clinical), Biological Psychiatry
Published: 2019
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38. A NOTE ON THE ASYMPTOTIC VARIANCE OF DRIFT ACCELERATED DIFFUSIONS

Author: A. Ouled Said, B. Franke, Chii-Ruey Hwang, H.-M. Pai, Laboratoire de Mathématiques de Bretagne Atlantique (LMBA), Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS), and Franke, Brice
Subjects: Statistics and Probability, [MATH.MATH-PR] Mathematics [math]/Probability [math.PR], 010102 general mathematics, Zero (complex analysis), [MATH] Mathematics [math], 01 natural sciences, Sobolev space, Markov chain monte carlo algorithm, [MATH.MATH-PR]Mathematics [math]/Probability [math.PR], 010104 statistics & probability, Delta method, Operator (computer programming), Kernel (statistics), [MATH.MATH-SP] Mathematics [math]/Spectral Theory [math.SP], Applied mathematics, Spectral analysis, 0101 mathematics, Statistics, Probability and Uncertainty, Diffusion (business), [MATH]Mathematics [math], Mathematics, [MATH.MATH-SP]Mathematics [math]/Spectral Theory [math.SP]
Abstract: The asymptotic variance is a natural indicator of the efficiency for a Markov Chain Monte Carlo algorithm. In this note, we prove that the asymptotic variance of a drift accelerated diffusion converges to zero uniformly if and only if there are no non-trivial first order Sobolev functions in the kernel of the drift generating operator. Its proof is based on spectral analysis in the first order Sobolev space of mean zero functions.
Published: 2019

39. Processive extrusion of polypeptide loops by a Hsp100 disaggregase

Author: Mario J, Avellaneda, Kamila B, Franke, Vanda, Sunderlikova, Bernd, Bukau, Axel, Mogk, and Sander J, Tans
Subjects: Adenosine Triphosphatases, Proteasome Endopeptidase Complex, Optical Tweezers, Arabidopsis Proteins, Ubiquitin, Escherichia coli Proteins, Endopeptidase Clp, Fluorescence, Protein Refolding, Kinetics, Protein Aggregates, Protein Multimerization, Peptides, Heat-Shock Proteins, Molecular Chaperones
Abstract: The ability to reverse protein aggregation is vital to cells
Published: 2019

40. Direct Oral Anticoagulants in Patients with Antiphospholipid Syndrome: Results from a Retrospective Study in a Real-life Patient Cohort

Author: Ulrich J. Sachs, B. Luxembourg, B. Franke, and Bettina Kemkes-Matthes
Subjects: Pediatrics, medicine.medical_specialty, business.industry, Antiphospholipid syndrome, Cohort, medicine, In patient, Retrospective cohort study, business, medicine.disease
Published: 2019
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41. School Behavioral Health : Interconnecting Comprehensive School Mental Health and Positive Behavior Support

Author: Mark D. Weist, Kathleen B. Franke, Robert N. Stevens, Mark D. Weist, Kathleen B. Franke, and Robert N. Stevens
Subjects: Education and state, Behavior disorders in children--Treatment, School mental health services, School psychology, Child psychology
Abstract: This book examines the prevalence of emotional and behavioral problems in youth and the implications of little or low-quality mental health services available for them. It describes aspects of Positive Behavioral Interventions and Supports (PBIS) and school mental health (SMH) that work together to form a comprehensive service delivery model called the Interconnected Systems Framework (ISF). The term school behavioral health (SBH) is used to describe SMH and PBIS working together, as in the ISF. The book examines perspectives of key stakeholders through a series of research forums, during which participants identified critical themes for the advancement of SBH in South Carolina and the southeast region of the United States. Chapters address key themes of school behavioral health from these forums, such as collaboration, schoolwide approaches, quality of services, and support for specific populations, including military families and youth involved in the juvenile justiceand child welfare systems. The book addresses barriers to providing behavioral health services at school as well as recommendations from key stakeholders for advancing SBH along these critical dimensions. This volume is a must-have resource for researchers, professors, and graduate students as well as practitioners, clinicians, and therapists across such interrelated disciplines as clinical child and school psychology, educational policy and politics, social work, public health, school counseling, family studies, juvenile justice, child and adolescent psychiatry, and child welfare and well-being services.
Published: 2020

42. Medical student knowledge and critical appraisal of machine learning: a multicentre international cross‐sectional study.

Author: Blacketer, Charlotte, Parnis, Roger, B. Franke, Kyle, Wagner, Morganne, Wang, David, Tan, Yiran, Oakden‐Rayner, Luke, Gallagher, Steve, Perry, Seth W., Licinio, Julio, Symonds, Ian, Thomas, Josephine, Duggan, Paul, and Bacchi, Stephen
Subjects: NATIONAL competency-based educational tests, MEDICAL students, HEALTH occupations students, CROSS-sectional method, MACHINE learning, TASK performance
Abstract: To utilise effectively tools that employ machine learning (ML) in clinical practice medical students and doctors will require a degree of understanding of ML models. To evaluate current levels of understanding, a formative examination and survey was conducted across three centres in Australia, New Zealand and the United States. Of the 245 individuals who participated in the study (response rate = 45.4%), the majority had difficulty with identifying weaknesses in model performance analysis. Further studies examining educational interventions addressing such ML topics are warranted. [ABSTRACT FROM AUTHOR]
Published: 2021
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43. Bacterial and Yeast AAA + Disaggregases ClpB and Hsp104 Operate through Conserved Mechanism Involving Cooperation with Hsp70

Author: Bernd Bukau, Kamila B. Franke, Axel Mogk, Anna Szlachcic, Eva Kummer, and Sophia Ungelenk
Subjects: 0301 basic medicine, Saccharomyces cerevisiae Proteins, Protein subunit, Saccharomyces cerevisiae, Protein Aggregates, 03 medical and health sciences, Structural Biology, Heat shock protein, Protein Interaction Mapping, Escherichia coli, HSP70 Heat-Shock Proteins, Molecular Biology, Heat-Shock Proteins, Derepression, biology, Escherichia coli Proteins, Endopeptidase Clp, biology.organism_classification, Cell biology, 030104 developmental biology, Proteostasis, Biochemistry, Chaperone (protein), biology.protein, Protein folding, CLPB
Abstract: Escherichia coli ClpB and Saccharomyces cerevisiae Hsp104 are members of the Hsp100 family of ring-forming hexameric AAA+ chaperones that promote the solubilization of aggregated proteins and the propagation of prions. ClpB and Hsp104 cooperate with cognate Hsp70 chaperones for substrate targeting and activation of ATPase and substrate threading, achieved by transient Hsp70 binding to the repressing ClpB/Hsp104 M-domain. Fundamental differences in ATPase regulation and disaggregation mechanisms have been reported; however, these differences are raising doubts regarding the working principle of this AAA+ chaperone. In particular, unique functional plasticity was suggested to specifically enable Hsp104 to circumvent Hsp70 requirement for derepression in protein disaggregation and prion propagation. We show here that both ClpB and Hsp104 cooperation with Hsp70 is crucial for efficient protein disaggregation and, in contrast to earlier claims, cannot be circumvented by activating M-domain mutations. Activation of ClpB and Hsp104 requires two signals, relief of M-domain repression and substrate binding, leading to increased ATPase subunit coupling. These data demonstrate that ClpB and Hsp104 operate by the same basic mechanism, underscore a dominant function of Hsp70 in regulating ClpB/Hsp104 activity, and explain a plethora of in vivo studies showing a crucial function of Hsp70 in proteostasis and prion propagation.
Published: 2016
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44. An open, non-comparative, multicentre evaluation of performance and safety using an antimicrobial exudate transfer dressing on diabetic foot ulcers: a case series

Author: C Gooday, B Franke, A Flanagan, Ketan Dhatariya, T Pilling, and L Zeidan
Subjects: Adult, Male, Exudate, medicine.medical_specialty, Nursing (miscellaneous), Visual analogue scale, Wound size, Silicones, 030209 endocrinology & metabolism, Signs and symptoms, Dressing change, Cohort Studies, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Prospective Studies, Aged, Pain Measurement, Aged, 80 and over, integumentary system, business.industry, Silver Compounds, Exudates and Transudates, Middle Aged, Antimicrobial, medicine.disease, Bandages, Diabetic foot, Wound infection, Diabetic Foot, Surgery, Patient Satisfaction, Anti-Infective Agents, Local, Wound Infection, Female, Fundamentals and skills, medicine.symptom, business
Abstract: Objective: To evaluate the performance and safety of Mepilex Transfer Ag (MTAg) in the treatment of infected diabetic foot ulcers (DFU). Method: Patients with locally infected DFU were treated with the test dressing for up to 4 weeks, with a further 12 weeks of follow-up in a non-comparative study. Changes to wound infection and wound size as well as the condition of the peri-wound skin from baseline were assessed. Wound pain during dressing change was measured using a visual analogue scale (VAS). The investigators and patients documented their opinions on their overall experience of the test dressing and on key performance parameters. Results: Following treatment with the test dressing, the signs and symptoms of local wound infection present in the target DFU were substantially reduced compared with baseline. Following the posttreatment evaluation, the majority of the DFU exhibited no signs of infection. and mean wound size was reduced by 50%. Wound size also continued to steadily decrease during follow-up. At the end of treatment five DFUs were completely healed and a further six healed by the end of the follow-up period. Concomitantly, over the course of the study, wound exudate levels were reduced and there was a significant improvement in the condition of the peri-wound area. Wound pain at dressing change was low throughout; generally patients felt no anxiety during the dressing change procedure. The patients considered it a comfortable dressing that remained in place and allowed ease of movement during wear. The investigating clinicians were highly satisfied with the overall performance, especially with respect to its ease of application and removal, conformability and flexibility. Conclusion: This study has demonstrated the potential of the dressing to provide topical antimicrobial activity directly to an infected DFU, suggesting prompt treatment of an infected DFU with this topical antimicrobial could aid wound complications. Declaration of interest: The authors have no conflict of interest to declare.
Published: 2016
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45. Publisher Correction: Processive extrusion of polypeptide loops by a Hsp100 disaggregase

Author: Kamila B. Franke, Axel Mogk, Vanda Sunderlikova, Mario J. Avellaneda, Sander J. Tans, and Bernd Bukau
Subjects: Multidisciplinary, Chemistry, Published Erratum, Biophysics, Extrusion
Published: 2020
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46. Meta-analysis and systematic review of ADGRL3 (LPHN3) polymorphisms in ADHD susceptibility

Author: E M, Bruxel, C R, Moreira-Maia, G C, Akutagava-Martins, T P, Quinn, M, Klein, B, Franke, M, Ribasés, P, Rovira, C, Sánchez-Mora, D B, Kappel, N R, Mota, E H, Grevet, C H D, Bau, M, Arcos-Burgos, L A, Rohde, and M H, Hutz
Subjects: Adult, Receptors, Peptide, Attention Deficit Disorder with Hyperactivity, Humans, Genetic Predisposition to Disease, Child, Polymorphism, Single Nucleotide, Genetic Association Studies, Receptors, G-Protein-Coupled
Abstract: The gene encoding adhesion G protein-coupled receptor L3 (ADGRL3, also referred to as latrophilin 3 or LPHN3) has been associated with ADHD susceptibility in independent ADHD samples. We conducted a systematic review and a comprehensive meta-analysis to summarize the associations between the most studied ADGRL3 polymorphisms (rs6551665, rs1947274, rs1947275, and rs2345039) and both childhood and adulthood ADHD. Eight association studies (seven published and one unpublished) fulfilled criteria for inclusion in our meta-analysis. We also incorporated GWAS data for ADGRL3. In order to avoid overlapping samples, we started with summary statistics from GWAS samples and then added data from gene association studies. The results of our meta-analysis suggest an effect of ADGRL3 variants on ADHD susceptibility in children (n = 8724/14,644 cases/controls and 1893 families): rs6551665 A allele (Z score = -2.701; p = 0.0069); rs1947274 A allele (Z score = -2.033; p = 0.0421); rs1947275 T allele (Z score = 2.339; p = 0.0978); and rs2345039 C allele (Z score = 3.806; p = 0.0026). Heterogeneity was found in analyses for three SNPs (rs6551665, rs1947274, and rs2345039). In adults, results were not significant (n = 6532 cases/15,874 controls): rs6551665 A allele (Z score = 2.005; p = 0.0450); rs1947274 A allele (Z score = 2.179; p = 0.0293); rs1947275 T allele (Z score = -0.822; p = 0.4109); and rs2345039 C allele (Z score = -1.544; p = 0.1226). Heterogeneity was found just for rs6551665. In addition, funnel plots did not suggest publication biases. Consistent with ADGRL3's role in early neurodevelopment, our findings suggest that the gene is predominantly associated with childhood ADHD.
Published: 2018

47. A beamline for fundamental neutron physics at TRIUMF

Author: Leonid Kurchaninov, Y. Bylinsky, S. Sidhu, C.B. Bidinosti, W.R. Rawnsley, S. Vanbergen, W. Klassen, M. Das, B. Thorsteinson, L. Rebenitsch, L. Lee, R. Mammei, Michael Gericke, A. Konaka, R. Picker, E. Korkmaz, David J. Jones, W. D. Ramsay, A. Sikora, E. Pierre, Yutaka Watanabe, M. Lang, T. Lindner, Kirk W. Madison, W. Schreyer, D. Yosifov, B. Jamieson, M. Hahn, Juliette Mammei, P. Giampa, Jeff Sonier, J.W. Martin, Y.-N. Rao, B. Franke, M.J. Barnes, C.A. Remon, T. Andalib, F. Kuchler, S. Ahmed, K. Katsika, Shinsuke Kawasaki, W. T. H. van Oers, S. Hansen-Romu, R. Matsumiya, J. Chak, Kichiji Hatanaka, and C. A. Davis
Subjects: Physics, Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, Proton, 010308 nuclear & particles physics, Cyclotron, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), 7. Clean energy, 01 natural sciences, Neutron physics, law.invention, Nuclear physics, Beamline, law, 0103 physical sciences, Ultracold neutrons, Neutron source, Spallation, Detectors and Experimental Techniques, 010306 general physics, Instrumentation, physics.ins-det, Beam (structure)
Abstract: This article describes the new primary proton beamline 1U at TRIUMF. The purpose of this beamline is to produce ultracold neutrons (UCN) for fundamental-physics experiments. It delivers up to 40 µA of 480 MeV protons from the TRIUMF cyclotron to a tungsten spallation target and uses a fast kicker to share the beam between the Center for Molecular and Materials Science and UCN. The beamline has been successfully commissioned and operated with a beam current up to 10 µA, facilitating first large-scale UCN production in Canada. This article describes the new primary proton beamline 1U at TRIUMF. The purpose of this beamline is to produce ultracold neutrons (UCN) for fundamental-physics experiments. It delivers up to 40 microA of 480 MeV protons from the TRIUMF cyclotron to a tungsten spallation target and uses a fast kicker to share the beam between the Center for Molecular and Materials Science and UCN. The beamline has been successfully commissioned and operated with a beam current up to 10 microA, facilitating first large-scale UCN production in Canada.
Published: 2018

48. Pathogenic TFG Mutations Underlying Hereditary Spastic Paraplegia Impair Secretory Protein Trafficking and Axon Fasciculation

Author: Edwin R. Chapman, Amber L. Schuh, Jennifer Bird, Samuel E. Butcher, Anjon Audhya, E. B. Franke, Erin L. Slosarek, Scott M. Stagg, Michael D. Sheets, David A. Ruhl, Kyle Quinney, Jordan E. Burke, Michael G. Hanna, Adam Johnson, Nilakshee Bhattacharya, and Matthew C. Johnson
Subjects: Axon Fasciculation, Mutation, Secretory protein, Hereditary spastic paraplegia, Endoplasmic reticulum, medicine, Secretion, Biology, Amyotrophic lateral sclerosis, medicine.disease, medicine.disease_cause, Cell biology, Transport protein
Abstract: Length-dependent axonopathy of the corticospinal tract causes lower limb spasticity and weakness and is characteristic of several neurological disorders, including hereditary spastic paraplegia (HSP) and amyotrophic lateral sclerosis (ALS). Mutations in tropomyosin-receptor kinase fused gene (TFG) have been implicated in both disease states, but the pathomechanisms by which these alterations cause neuropathy remain unclear. Here, we biochemically and genetically define the impact of a mutation within the coiled coil domain of TFG, which underlies early onset forms of HSP. We find that the TFG (p.R106C) mutation alters compaction of TFG ring complexes, which play a critical role in the export of cargoes from the endoplasmic reticulum (ER). Moreover, using CRISPR-mediated genome editing, we engineered human stem cells that express the mutant form of TFG at endogenous levels and identified specific defects in secretion from the ER and axon fasciculation following neuronal differentiation. Together, our data highlight a key role for TFG-mediated protein transport in the pathogenesis of HSP.
Published: 2018
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49. Demonstration of sensitivity increase in mercury free-spin-precession magnetometers due to laser-based readout for neutron electric dipole moment searches

Author: Geza Zsigmond, M. Daum, Jacek Zejma, Nathal Severijns, M. Rawlik, Y. Kermaidic, A. Kozela, P. Prashanth, A. Mtchedlishvili, Philipp Schmidt-Wellenburg, Bernhard Lauss, Georg Bison, Florian M. Piegsa, G. Quéméner, Grzegorz Wyszyński, D. Ries, Antoine Weis, H.-C. Koch, D. Rozpedzik, J. Krempel, S. Roccia, Martin Fertl, Malgorzata Kasprzak, B. Franke, Werner Heil, Zoran D. Grujić, M. Horras, G. Ban, D. Rebreyend, S. Komposch, Kazimierz Bodek, Klaus Kirch, Guillaume Pignol, T. Lefort, Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Laboratoire de physique corpusculaire de Caen ( LPCC ), Université de Caen Normandie ( UNICAEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Ecole Nationale Supérieure d'Ingénieurs de Caen ( ENSICAEN ), Normandie Université ( NU ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physique Subatomique et de Cosmologie ( LPSC ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Centre de Sciences Nucléaires et de Sciences de la Matière ( CSNSM ), and Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS )
Subjects: Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, Neutron electric dipole moment, Atomic Physics (physics.atom-ph), Magnetometer, atomic spectroscopy, FOS: Physical sciences, Atomic spectroscopy, Neutron, electric dipole moment, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, law.invention, High Energy Physics - Experiment, Physics - Atomic Physics, High Energy Physics - Experiment (hep-ex), symbols.namesake, neutron, law, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], [ PHYS.NEXP ] Physics [physics]/Nuclear Experiment [nucl-ex], Nuclear Experiment (nucl-ex), 010306 general physics, Zeeman effect, Mercury, Electric dipole moment, [ PHYS.PHYS.PHYS-INS-DET ] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Instrumentation, Nuclear Experiment, Physics, 010308 nuclear & particles physics, Instrumentation and Detectors (physics.ins-det), Laser, Computational physics, Magnetic field, symbols
Abstract: International audience; We report on a laser based $^{199}$Hg co-magnetometer deployed in an experiment searching for a permanent electric dipole moment of the neutron. We demonstrate a more than five times increased signal to-noise-ratio in a direct comparison measurement with its $^{204}$Hg discharge bulb-based predecessor. An improved data model for the extraction of important system parameters such as the degrees of absorption and polarization is derived. Laser- and lamp-based data-sets can be consistently described by the improved model which permits to compare measurements using the two different light sources and to explain the increase in magnetometer performance. The laser-based magnetometer satisfies the magnetic field sensitivity requirements for the next generation nEDM experiments.
Published: 2018
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50. P.2.24 Brain and behavioural changes in mice colonized with human ADHD gut microbiota

Author: S. Dam, A. Tengeler, M. Wiesmann, C. Belzer, B. Franke, T. Kozicz, A. AriasVasquez, and A. Kiliaan
Subjects: Pharmacology, Psychiatry and Mental health, Neurology, Pharmacology (medical), Neurology (clinical), Biological Psychiatry
Published: 2019
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