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2. Combined drug design of potential Mycobacterium tuberculosis and HIV-1 inhibitors: 3’,4’-di-substituted -4'H-spiro[isothiochromene-3,5'-isoxazol]-4(1H)-one

Author

Abdelali Kerbal, Brahim Bennani, B. Filali Baba, T. Ben Hadda, G. Al Houari, Abraham F. Jalbout, S. Öztürk Yıldırım, Mohammed Benazza, Gilles Demailly, Mostafa Mimouni, Mehmet Akkurt, and M. Daoudi

Subjects
Drug, biology, Chemistry, Stereochemistry, media_common.quotation_subject, Organic Chemistry, Human immunodeficiency virus (HIV), medicine.disease_cause, biology.organism_classification, In vitro, Virus, Mycobacterium tuberculosis, lcsh:QD241-441, lcsh:Organic chemistry, Mic values, medicine, Pharmacophore, Bacteria, media_common
Abstract

We report herein the design and synthesis of 17 new spiroheterocycles 10-26, on the basis of two hypothetical pharmacophore structures designed to interact with both of Mycobacterium tuberculosis bacteria and HIV-1 virus. The in vitro biological evaluation of these compounds allowed us to point out seven new potential non-nucleoside hits, with MIC values in the range of 6.25 mu g/mL and two new potential anti-HIV-1 inhibitors.

Published
2007

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