11 results on '"B. C. Goverde"'
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2. Abstracts of Dutch doctoral theses
- Author
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G. J. Navis, G. J. Sterk, J. W. van Nispen, M. Hichens, A. Sauter, H. Lingeman, C. M. B. van den Beld, U. R. Tjaden, J. van der Greef, D. M. Desiderio, D. C. Cubbins, C. McMartin, R. L. Webb, L. P. Wennogle, H. E. Wysowskyi, M. B. Zimmerman, V. H. L. Lee, J. Sandow, H. Seidel, R. Schmiedel, Bradley T. Keller, Kevin R. Smith, Ronald T. Borchardt, W. A. Banks, A. J. Kastin, D. de Wied, P. P. DeLuca, J. R. Robinson, S. Lundin, H. Vilhardt, M. Saffran, G. S. Kumar, D. G. Neckers, F. Williams, J. B. Field, R. H. Jones, L. Panepinto, A. S. Harris, Alan C. Moses, S. Muranishi, H. E. Boddé, M. Ponec, J. Verhoef, Gary G. Liversidge, G. J. Boer, J. Kruisbrink, H. de Nijs, T. R. M. Bouwman, M. J. D. Eenink, Harish M. Patel, H. Bundgaard, J. D. Larsen, M. N. Nielsen, A. Buur, U. R. Tjadeh, M. Lemaire, H. Andres, P. Marbach, L. Widlund, O. Guilbaud, P. Wilton, J. B. M. M. van Bree, K. L. Audus, Johanna Deinum, Karin Norén, Morgan Sohtell, B. R. Weström, H. G. Folkesson, B. W. Karlsson, C. Damge, C. Michel, M. Aprahamian, P. Couvreur, F. Puisieux, E. Touitou, F. Alhaique, P. Fisher, A. Memoli, F. M. Riccieri, E. Santucci, W. A. J. J. Hermens, S. G. Romei jn, F. W. H. H. Merkus, C. Schneider, T. W. Smith, K. -D. Bremecker, K. -D. Hungerer, Y. Tabata, Y. Ikada, K. Uno, S. Muramatsu, J. W. Bruning, F. H. J. Claas, M. J. Kardol, J. M. van Ree, C. J. J. Rust, W. Verduyn, V. M. Wiegant, G. Wolterink, E. J. van Hoogdalem, C. D. Heijligers-Feijen, A. G. de Boer, D. D. Breimer, C. B. Lambalk, H. van Kessel, J. de Koning, J. A. M. J. van Dieten, G. P. van Rees, J. Schoemaker, J. -Ph. Devissaguet, K. Orieu, F. Dray, E. Ezan, J. Ph. Devissaguet, K. Drieu, P. Dray, E. Ezah, D. J. Barnfield, Y. K. Barker, S. Knott, G. S. Miles, A. Warrander, H. K. Adam, Y. Barker, F. G. Hutchinson, R. A. V. Milsted, R. H. Moore, A. J. Swaisland, Y. Barke, E. T. Porter, B. Holmes, M. Barnard, J. H. Beijnen, S. C. H. Lubbers, O. A. G. J. van der Houwen, M. W. Lobbezoo, W. J. M. Underberg, Th. Cachet, E. Roets, J. Hoogmartens, H. Vanderhaeghe, H. de Bree, D. J. K. van der Stel, O. A. M. Brockhoff, M. P. van Berkel, K. Sierat, G. de Groot, B. C. A. Tepas, O. E. de Noord, J. Hempenius, P. M. J. Coenegracht, J. H. G. Jonkman, D. A. Doornbos, J. A. De Schutter, P. De Moerloose, L. P. C. Delbressine, F. M. Kaspersen, A. Blokland, A. L. L. Duchateau, T. A. Verstappen, P. J. H. Hendricks, F Elferink, O R Leeuwenkamp, H M Pinedo, W J F vd Vijgh, K. Ensing, D. A. Bloemhof, W. G. In 't Hout, R. A. de Zeeuw, Karla G. Feitsma, Ben F. H. Drenth, Rokus A. de Zeeuw, T. K. Gerding, B. F. H. Drenth, A. S. Horn, C. P. Groen, J. Tipker, J. K. van den Bergh-Swart, F. J. Spruit, J. H. M. van den Berg, E. H. Groot Bramel, O. Bekers, M. Otagiri, P. S. L. Janssen, J. W. v. Nispen, P. A. T. A. Melgers, M. J. M. v. Zeeland, R. L. A. E. Hamelinck, B. C. Goverde, G. W. M. v. Aalst, P. R. Kootstra, H. H. van den Broek, E. A. Hogendoorn, C. E. Goewie, P. J. M. Kwakman, U. A. Th. Brinkman, R. W. Frei, G. J. de Jong, N. G. F. M. Lammers, N. Lammers, H. M. Ruijten, J. de Jong, P. A. Maessen, K. B. Mross, H. M. Plnedo, W. J. F. van der Vljgh, Naeem Hasan Khan, S. V. Rose, L. G. D. Lammerts van Bueren, P. H. van Amsterdam, H. van Beek, A. J. Baars, L. A. van Ginkel, H. M. Steinbuch, H. J. van Rossum, H. van Blitterswijk, P. W. Zoontjes, E. v. d. Heeft, A. J. P. M. de Jong, R. W. Stephany, R. van Gijn, J. J. M. de Clippeleir, S. L. Verweij, A. C. A. Paalman, M. A. J. van Opstal, P. Krabbenborg, J. J. M. Holthuis, W. P. van Bennekom, A. Bult, F. A. M. Redegeld, E. Houdkamp, C. van de Water, N. Haagsma, D. E. M. M. Vendrig, A. Mekking, and J. Teeuwsen
- Subjects
Pharmacology ,Ketanserin ,Chemistry ,Lisinopril ,Renal function ,Propranolol ,Natriuresis ,Blood pressure ,medicine ,Pharmacology (medical) ,Chlorthalidone ,Enalapril ,medicine.drug - Published
- 1988
- Full Text
- View/download PDF
3. HPLC analysis of phenylthiocarbamyl (PTC) amino acids. I. Evaluation and optimization of the procedure
- Author
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H. W. M. van den Bogaart, B. C. Goverde, J. W. Van Nispen, R. L. A. E. Hamelinck, P. S. L. Janssen, and P. A. T. A. Melgers
- Subjects
chemistry.chemical_classification ,Hplc analysis ,Chromatography ,endocrine system diseases ,Organic Chemistry ,Clinical Biochemistry ,Peptide ,Buffer solution ,Biochemistry ,High-performance liquid chromatography ,Analytical Chemistry ,Amino acid ,chemistry.chemical_compound ,Hydrolysis ,Amino acid analysis ,chemistry ,Derivatization - Abstract
An HPLC system has been developed in which 23 phenylthiocarbamyl (PTC) amino acids are distinctly separated. Applying this system, the preceding steps in HPLC amino acid analysis i.e. gas-phase hydrolysis of the protein/peptide sample and the pre-column derivatization, were evaluated and optimized. PTC amino acids in HPLC buffer solution are stable for at least 16 hours if stored at 5°–8°C. The sensitivity of the method is in the low pmol range.
- Published
- 1986
- Full Text
- View/download PDF
4. Abstracts of lectures symposium disposition and delivery of peptide drugs
- Author
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H. M. Pinedo, Rokus A. de Zeeuw, E. A. Hogendoorn, R. van Gijn, S. V. Rose, M. Barnard, H. H. van den Broek, O. A. G. J. van der Houwen, H. M. Ruijten, P. De Moerloose, M. A. J. van Opstal, A. J. Baars, A. Bult, L. G. D. Lammerts van Bueren, K. Ensing, E. v.d. Heeft, J. H. G. Jonkman, W. P. van Bennekom, L. P. C. P. Delbressine, R. W. Frei, H. J. van Rossum, W. G. in 't Hout, C. van de Water, J. J. M. de Clippeleir, Ben F. H. Drenth, K. Sierat, U. A. Th. Brinkman, N. Haagsma, G. de Groot, Naeem Hasan Khan, E. H. Groot Bramel, D. J. K. van der Stel, C. P. Groen, W. J. M. Underberg, P. S. L. Janssen, D. E. M. M. Vendrig, J. A. De Schutter, P. A. Maessen, M. J. M. v. Zeeland, A. Mekking, P. J. M. Kwakman, J. H. N. van den Berg, A. L. L. Duchateau, J. K. van den Bergh-Swart, H. Vanderhaeghe, P. A. T. A. Melgers, M. W. Lobbezoo, C. E. Goewie, H. de Bree, N. G. F. M. Lammers, H. M. Steinbuch, P. W. Zoontjes, R.A. de Zeeuw, B. C. Goverde, J. Hempenius, A. S. Horn, D. A. Bloemhof, E. Roets, O. A. M. Brockhoff, R. L. A. E. Hanmelinck, M. Otagiri, P. M. J. Coenegracht, D. A. Doornbos, F. J. Spruit, T. K. Gerding, Th. Cachet, O. E. de Noord, Karla G. Feitsma, S. C. M. Lubbers, H. van Blitterswijk, O. R. Leeuwenkamp, R. W. Stephany, M. P. van Berkel, S. L. Verweij, G. J. de Jong, B. F. H. Drenth, W. J. F. van der Vijgh, P. Krabbenborg, J.M. van den Berg, H. van Beek, O. Beckers, A. C. A. Paalman, F. M. Kaspersen, W. J. F. vd Vijh, N. Lammers, L. A. van Ginkel, J. Hoogmartens, P. J. H. Hendricks, K. B. Mross, T. A. Verstappen, J. Teeuwsen, J. J. M. Holthuis, J. Tipker, G. W. M. v. Aalst, P. R. Kootstra, J. W. v. Nispen, Jos H. Beijnen, F. Elferink, B. C. A. Tepas, A. Blokland, and A. J. P. M. de Jong
- Subjects
Pharmacology ,chemistry.chemical_classification ,chemistry ,business.industry ,Medicine ,Pharmacology (medical) ,Peptide ,Disposition ,Peptide hormone ,business ,Peptide drug - Abstract
A number of different processes clear peptides from the circulation. These will be described and illustrated using examples from a range of peptide hormones and analogues.
- Published
- 1988
- Full Text
- View/download PDF
5. Abstracts of papers symposium disposition and delivery of peptide drugs
- Author
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M. Barnard, J. H. Beijnen, S. C. M. Lubbers, O. A. G. J. van der Houwen, M. W. Lobbezoo, W. J. M. Underberg, Th. Cachet, E. Roets, J. Hoogmartens, H. Vanderhaeghe, H. de Bree, D. J. K. van der Stel, O. A. M. Brockhoff, M. P. van Berkel, K. Sierat, G. de Groot, B. C. A. Tepas, O. E. de Noord, J. Hempenius, P. M. J. Coenegracht, J. H. G. Jonkman, D. A. Doornbos, J. A. De Schutter, P. De Moerloose, L. P. C. P. Delbressine, F. M. Kaspersen, A. Blokland, A. L. L. Duchateau, T. A. Verstappen, P. J. H. Hendricks, F. Elferink, O. R. Leeuwenkamp, H. M. Pinedo, W. J. F. vd Vijh, K. Ensing, D. A. Bloemhof, W. G. in 't Hout, R. A. de Zeeuw, Karla G. Feitsma, Ben F. H. Drenth, Rokus A. de Zeeuw, T. K. Gerding, B. F. H. Drenth, A. S. Horn, C. P. Groen, J. Tipker, J. K. van den Bergh-Swart, F. J. Spruit, J. H. N. van den Berg, E. H. Groot Bramel, O. Beckers, M. Otagiri, P. S. L. Janssen, J. W. v. Nispen, P. A. T. A. Melgers, M. J. M. v. Zeeland, R. L. A. E. Hanmelinck, B. C. Goverde, G. W. M. v. Aalst, P. R. Kootstra, H. H. van den Broek, E. A. Hogendoorn, C. E. Goewie, P. J. M. Kwakman, U. A. Th. Brinkman, R. W. Frei, G. J. de Jong, N. G. F. M. Lammers, J. H. M. van den Berg, N. Lammers, H. M. Ruijten, P. A. Maessen, K. B. Mross, W. J. F. van der Vijgh, Naeem Hasan Khan, S. V. Rose, L. G. D. Lammerts van Bueren, H. van Beek, A. J. Baars, L. A. van Ginkel, H. M. Steinbuch, H. J. van Rossum, H. van Blitterswijk, P. W. Zoontjes, E. v.d. Heeft, A. J. P. M. de Jong, R. W. Stephany, R. van Gijn, J. J. M. de Clippeleir, S. L. Verweij, A. C. A. Paalman, M. A. J. van Opstal, P. Krabbenborg, J. J. M. Holthuis, W. P. van Bennekom, A. Bult, C. van de Water, N. Haagsma, D. E. M. M. Vendrig, A. Mekking, and J. Teeuwsen
- Subjects
Pharmacology ,Pharmacology (medical) - Published
- 1988
- Full Text
- View/download PDF
6. Boekbesprekingen
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A. W. M. Indemans, J. J. Vink-Stephan, A. C. Van Loenen, B. C. Goverde, J. M. H. Conemans, N. P. E. Verméulen, and J. Sagel
- Subjects
Pharmacology ,Pharmacology (medical) - Published
- 1981
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- View/download PDF
7. HPLC analysis of phenylthiocarbamyl (PTC) amino acids II. Application in the analysis of (poly)peptides
- Author
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J. W. Van Nispen, H. W. M. van den Bogaart, P. A. T. A. Melgers, G. W. M. van Aalst, B. C. Goverde, and P. S. L. Janssen
- Subjects
chemistry.chemical_classification ,Hplc analysis ,Chromatography ,Organic Chemistry ,Clinical Biochemistry ,Peptide ,Biochemistry ,High-performance liquid chromatography ,Analytical Chemistry ,Gas phase ,Amino acid ,chemistry.chemical_compound ,Hydrolysis ,Amino acid analysis ,chemistry ,Derivatization - Abstract
The composition of 10 known (poly)peptides of widely different nature was determined by a previously optimized HPLC-PTC amino acid analysis; for the gasphase hydrolysis and the derivatization step use was made of a Pico-Tag Workstation. Results are in good agreement with those of the classical Moore and Stein technique.
- Published
- 1986
- Full Text
- View/download PDF
8. STUDIES ON HUMAN CHORIONIC GONADOTROPHIN
- Author
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B. C. Goverde, F. J. N. Veenkamp, and J. D. H. Homan
- Subjects
Endocrinology ,Endocrinology, Diabetes and Metabolism ,General Medicine - Abstract
Six preparations of Human Chorionic Gonadotrophin (HCG), differing in purity and biological potency, were analysed for their carbohydrate and amino acid composition. The results of the determinations indicated a certain relation between the biological potency on the one hand, and the content of certain substances, particularly sialic acid and fucose (both carbohydrate terminal groups of glycoproteins), on the other. As the sialic acid fraction contained only N-acetyl-neuraminic acid (NANA), a true quantitative determination could be made. Two methods used for the release of NANA were compared and it was found that neuraminidase from Vibrio cholerae released 96% of the amount of NANA which could be released by 0.01 n hydrochloric acid hydrolysis. Based on the results of biological and NANA assays of 16 preparations, a mathematical relation between the biological potency and the NANA content, as an independent variable, was calculated. Membrane electrophoresis in Veronal-formamide buffer revealed a sharp band pattern, which could be explained by assuming a polymorphous HCG molecule, differing mainly in the number of terminal NANA groups. The prospects of a chemical assay of HCG based on the determination of NANA are, however, not at all encouraging.
- Published
- 1968
- Full Text
- View/download PDF
9. Application of reversed-phase HPLC in some critical peptide separations
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R. L. A. E. Hamelinck, B. C. Goverde, J. W. Van Nispen, P. A. T. A. Melgers, and P. S. L. Janssen
- Subjects
Chemical Phenomena ,Swine ,Peptide ,High-performance liquid chromatography ,Analytical Chemistry ,Adrenocorticotropic Hormone ,Animals ,Humans ,Insulin ,Endorphins ,Enantiomeric excess ,Chromatography, High Pressure Liquid ,chemistry.chemical_classification ,Chromatography ,Chemistry ,Chemistry, Physical ,beta-Endorphin ,INSULIN PREPARATIONS ,General Medicine ,Reversed-phase chromatography ,Peptide Fragments ,Rats ,Peptide chemistry ,Cattle ,Peptides - Abstract
The application of reversed-phase high performance liquid chromatography in peptide chemistry is illustrated. Its use is described for separation of closely related endorphins, as an optical purity criterion, for rapid determination of the species of origin of insulin preparations, and finally for analysis of small, basic (hydrophilic) peptides.
- Published
- 1984
10. Studies on human chorionic gonadotrophin. II. Chemical composition and its relation to biological activity
- Author
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B C, Goverde, F J, Veenkamp, and J D, Homan
- Subjects
Electrophoresis ,Time Factors ,Neuraminidase ,In Vitro Techniques ,Chorionic Gonadotropin ,Pregnancy ,Methods ,Humans ,Biological Assay ,Female ,Neuraminic Acids ,Hydrochloric Acid ,Mathematics ,Fucose ,Glycoproteins ,Vibrio - Published
- 1968
11. Purification, Characterization and Immunochemical Properties of Human Chorionic Gonadotropin
- Author
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A. H. W. M. Schuurs, H. Van Hell, R. Matthijsen, B. C. Goverde, E. De Jager, and J. D. H. Homan
- Subjects
Electrophoresis ,Chromatography ,Multidisciplinary ,biology ,Chemistry ,Immunochemistry ,Serum albumin ,Serum Albumin, Bovine ,Chorionic Gonadotropin ,Human chorionic gonadotropin ,Biochemistry ,Chromatography, Gel ,biology.protein ,Chemical Precipitation ,Humans ,Biological Assay ,Neuraminic Acids - Published
- 1966
- Full Text
- View/download PDF
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