Search

No abstract available.

This paper is focused on the nonmigrating tidal activity seen in the SABER/TIMED temperatures that is related to the major sudden stratospheric warming (SSW) taking place in the Arctic winter of 2003/2004. The emphasis is on the nonmigrating diurnal tides observed in the stratosphere and lower mesosphere which is usually accepted to be insignificant in comparison with that in the upper mesosphere and thermosphere. By using different independent spectral methods we found a significant amplification in December–January of the following nonmigrating 24-h tides: zonally symmetric (s=0), eastward propagating with zonal wavenumber 1 (E1), and westward propagating with zonal wavenumbers 2 and 3 (W2 and W3) tides. It has been found that the double peak nonmigrating tidal amplifications located in the stratosphere (~40 km) and in the lower mesosphere (~70 km) are a consequence of the maintained hydrostatic relation. By detailed comparison of the evolution and spatial structure of the nonmigrating diurnal tides with those of the migrating diurnal tide and stationary planetary waves (SPWs) evidence for a SPW-migrating tide interaction as a source of nonmigrating tides has been presented. Therefore, the nonmigrating 24-h tides turn out to be an important component of the middle atmosphere dynamics during the major SSW in the Arctic winter of 2003/2004.

The present paper is focused on the global spatial (altitude and latitude) structure, seasonal and interannual variability of the migrating semidiurnal tide derived from the SABER/TIMED temperature measurements for 6 years (January 2002–December 2007). The tidal results are obtained by a new analysis method where the tides (migrating and nonmigrating) and the planetary waves (zonally travelling and stationary) are simultaneously extracted from the satellite data. The strongest migrating semidiurnal tide has been derived at tropical latitudes (±20–30°) where it revealed significant amplification between May and August in the lower thermosphere of both hemispheres. On the average, the semidiurnal temperature tide is stronger in the SH (32 K) than that in the NH (30 K) and the tidal amplitudes at 110 km height are nearly a factor of 5 larger than those at 90 km. The migrating semidiurnal tide in both hemispheres revealed remarkable seasonal behavior at the altitude where it maximizes, ~110 km in the NH and ~115 km in the SH, indicating repeatable each year maxima exactly in May–June and August. However, while the main maximum in the NH is that in August, in the SH it is that in May. The vertical wavelengths indicated seasonal variability being larger in summer (~38–50 km) than in winter (~25–35 km). The seasonal behavior of the semidiurnal tide in the middle latitudes (±40°) is dominated by annual variability with a winter maximum in the upper mesosphere (90 km) of both hemispheres and summer one in the lower thermosphere (110 km). The NH summer maximum (June and August peaks) is much stronger than that in the SH (November and March peaks) having amplitudes of ~23 K and ~13–15 K respectively. The vertical wavelengths at both hemispheres indicated slight seasonal changes and a mean vertical wavelength of ~35 km is observed during most of the year. The interannual variability of the semidiurnal tide in the midlatitude lower thermosphere is at least partly connected with the stratospheric QBO as this effect is stronger in the NH.

This short-communication presents a new method for assessing the amplitude modulation of the stationary planetary waves (SPWs). The suggested procedure allows estimating the contribution of the amplitude modulated SPWs to the field of the zonally travelling planetary waves. The root of the method consists in calculating of a quantity that is analogous to 2-D Lomb-Scargle amplitude spectrum and also the relative error of the approximation. The amplitude "spectra" of the SPWs give information about the period(s) of modulation, while the relative errors - define the coefficient(s) of modulation. The suggested method is applied to the UKMO temperature data for the Arctic winter of 2004–2005.

The coupling of the dynamical regimes in the high- and low-latitude stratosphere and mesosphere during the major SSW in the Arctic winter of 2003/2004 has been studied. The UKMO zonal wind data were used to explore the latitudinal coupling in the stratosphere, while the coupling in the mesosphere was investigated by neutral wind measurements from eleven radars situated at high, high-middle and tropical latitudes. It was found that the inverse relationship between the variability of the zonal mean flows at high- and low-latitude stratosphere related to the SSW is produced by global-scale zonally symmetric waves. Their origin and other main features have been investigated in detail. Similar latitudinal dynamical coupling has been found for the mesosphere as well. Indirect evidence for the presence of zonally symmetric waves in the mesosphere has been found.

Population ageing is having a direct influence on serious health issues, including hampered mobility and physical decline. Good habits in performing physical activities, in addition to eating and drinking, are essential to improve the life quality of the elderly population. Technological solutions, aiming at increasing awareness or providing reminders to eat/drink regularly, can have a significant impact in this scenario. These solutions enable the possibility to constantly monitor deviations from users' normal behavior, thus allowing reminders to be provided to users/caregivers. In this context, this paper presents a radio-frequency identification (RFID) system to monitor user's habits, such as the use of food, beverages, and/or drugs. The device was optimized to fulfill specifications imposed by the addressed application. The approach could be extended for the monitoring of home appliances, environment exploitation, and activity rate. Advantages of the approach compared to other solutions, e.g., based on cameras, are related to the low level of invasiveness and flexibility of the adopted technology. A major contribution of this paper is related to the wide investigation of system behavior, which is aimed to define the optimal working conditions of the system, with regards to the power budget, user (antenna)-tag reading range, and the optimal inter-tag distance. To investigate the performance of the system in tag detection, experiments were performed in a scenario replicating a home environment. To achieve this aim, specificity and sensitivity indexes were computed to provide an objective evaluation of the system performance. For the case considered, if proper conditions are meet, a specificity value of 0.9 and a sensitivity value of 1 were estimated.

Infertility may be associated with severe psychological burden and many couples need mental support. We used dyadic approach to identify couples with disturbed psychological condition and we tested the WHO-5 Well-Being Index (WHO-5-WBI) questionnaire as a possible, rapid screening method. Extensive psychological assessment of infertile couples was carried out with Beck's Depression Inventory, Spielberger State-Trait Anxiety Inventory, WHO-5-WBI, Symptom Check List-90 Revised Test, Fagerstrom Test for Nicotine Dependence, Alcohol Use Disorders Identification Test. Data of 128 patients (64 couples) were used in the statistical calculations. The Two-Step cluster analysis has revealed 2 groups, which could be separated supremely based on the level of experienced depression, anxiety and according to the general mental health. The WHO-5-WBI questionnaire showed consistent results while classifying couples into groups, which were formed. Our results indicate that infertility affects both spouses almost in the same extent in several psychological aspects. A cluster of couples with increased psychological burden could be clearly separated. The WHO-5-WBI questionnaire was a promising tool to screen reliably spouses based on their psychological state and identify couples that need psychological support during their fertility work-up and treatment., Competing Interests: The authors have no competing interests to declare., (Copyright: © 2020 The Author(s).)

Background: The nature of episodic memory deficit in intermediate-term abstinence from alcohol in alcohol dependence (AD) is not yet clarified. Deficits in inhibitory control are commonly reported in substance use disorders. However, much less is known about cognitive control suppressing interference from memory. The Think/No-think (TNT) paradigm is a well established method to investigate inhibition of associative memory retrieval., Methods: Thirty-six unmedicated patients with AD and 36 healthy controls (HCs) performed the TNT task. Thirty image-word pairs were trained up to a predefined accuracy level. Cued recall was examined in three conditions: Think (T) for items instructed to-be-remembered, No-think (NT) assessing the ability to suppress retrieval and Baseline (B) for general relational memory. Premorbid IQ, clinical variables and impulsivity measures were quantified., Results: AD patients had a significantly increased demand for training. Baseline memory abilities and effect of practice on retrieval were not markedly different between the groups. We found a significant main effect of group (HC vs. AD) × condition (B, T, and NT) and a significant difference in mean NT-B scores for the two groups., Discussion: AD and HC groups did not differ essentially in their baseline memory abilities. Also, the instruction to focus on retrieval improved episodic memory performance in both groups. Crucially, control participants were able to suppress relational words in the NT condition supporting the critical effect of cognitive control processes over inhibition of retrieval. In contrast to this, the ability of AD patients to suppress retrieval was found to be impaired.

Visually impaired people are often discouraged in using electronic aids due to complexity of operation, large amount of training, nonoptimized degree of information provided to the user, and high cost. In this paper, a new multisensor architecture is discussed, which would help blind people to perform urban mobility tasks. The device is based on a multisensor strategy and adopts smart signal processing.

Dried-bonito broth (DBB, katsuo-bushi dashi) is commonly used in Japanese cuisine, and is also used as a traditional remedy for recovery from fatigue and improvement of blood circulation. To clarify the effect of DBB on blood pressure, oxidative stress and emotional states, a randomized crossover human trial was performed. Twenty-seven elderly Japanese subjects ingested DBB or water for one month. Measurement of blood pressure and urinary 8-hydroxydeoxyguanosine (8-OHdG) and evaluation of emotional states were performed before and after the ingestion periods. The changes in systolic blood pressure (SBP) during DBB ingestion was significantly lower than that during water ingestion (p = 0.037). Urinary 8-OHdG significantly decreased during DBB ingestion (p = 0.0002). Evaluation of emotional states indicated that composure significantly improved during DBB ingestion (p = 0.034). These results suggest that the daily ingestion of DBB lower SBP, reduce urinary 8-OHdG and might improve emotional states in elderly subjects.

It is well known that overdamped unforced dynamical systems do not oscillate. However, well-designed coupling schemes, together with the appropriate choice of initial conditions, can induce oscillations (corresponding to transitions between the stable steady states of each nonlinear element) when a control parameter exceeds a threshold value. In recent publications [A. Bulsara, Phys. Rev. E 70, 036103 (2004); V. In, ibid. 72, 045104 (2005)], we demonstrated this behavior in a specific prototype system, a soft-potential mean-field description of the dynamics in a hysteretic "single-domain" ferromagnetic sample. These oscillations are now finding utility in the detection of very weak "target" magnetic signals, via their effect on the oscillation characteristics--e.g., the frequency and asymmetry of the oscillation wave forms. We explore the underlying dynamics of a related system, coupled bistable "standard quartic" dynamic elements; the system shows similarities to, but also significant differences from, our earlier work. dc as well as time-periodic target signals are considered; the latter are shown to induce complex oscillatory behavior in different regimes of the parameter space. In turn, this behavior can be harnessed to quantify the target signal.

Magnetic bioassay is becoming of great interest in several application including magnetic separation, drug delivery, hyperthermia treatments, magnetic resonance imaging (MRI) and magnetic labelling. The latter can be used to localize bio-entities (e.g. cancer tissues) by using magnetic markers and high sensitive detectors. To this aim SQUIDs can be adopted, however this result in a quite sophisticated and complex method involving high cost and complex set-up. In this paper, the possibility to adopt RTD fluxgate magnetometers as alternative low cost solution to perform magnetic bio-sensing is investigated. Some experimental results are shown that encourage to pursue this approach in order to obtain simple devices that can detect a certain number of magnetic particles accumulated onto a small surface such to be useful for diagnosis purposes.

It is well known that overdamped unforced dynamical systems do not oscillate. However, well-designed coupling schemes, together with the appropriate choice of initial conditions, can induce oscillations when a control parameter exceeds a threshold value. In a recent publication [Phys. Rev. E 68, 045102 (2003)]], we demonstrated this behavior in a specific prototype system, a soft-potential mean-field description of the dynamics in a hysteretic "single-domain" ferromagnetic sample. The previous analysis of this work showed that N (odd) unidirectionally coupled elements with cyclic boundary conditions would, in fact, oscillate when a control parameter-in this case the coupling strength-exceeded a critical value. These oscillations are now finding utility in the detection of very weak "target" signals, via their effect on the oscillation characteristics, e.g., the frequency and asymmetry of the oscillation wave forms. In this paper we explore the underlying dynamics of this system. Scaling laws that govern the oscillation frequency in the vicinity of the critical point, as well as the zero-crossing intervals in the presence of a symmetry-breaking target dc signal, are derived; these quantities are germane to signal detection and analysis.

The patient was a woman of forty-eight. Liver dysfunction was pointed out at the age of forty-five. She was admitted to hospital because of her hyperthyroidism. Her palmar skin was wet and her fingers were swollen like sausages. She had a diffuse and elastic hard goiter with a rough surface. The serum levels of free T3 (9.6 pg/mL) and free T4 (3.76 ng/dL) were high and that of TSH (0.11 microU/mL) was low. The activity of TSH-binding inhibitory immunoglobulin (TBII) was 89%. The uptake rate of 123I to the thyroid was 55.1% and the uptake pattern was nearly diffuse. The goiter was proved to contain several nodules by ultrasonography, but aspiration cytology showed no malignant cells. She was diagnosed to have Graves' disease with adenomatous goiter. She also had high ALT (34 IU/L) and gamma-globulin (1.97 g/dL). She had positive antinuclear antibody (speckled type), positive anti-ribosomal nuclear protein antibody, and positive LE cell phenomenon. The liver biopsy revealed mononuclear cell infiltration with fibrosis in the portal area. These data indicated that she also had autoimmune hepatitis (AIH) and mixed connective tissue disease (MCTD). The analysis of human leukocyte antigen (HLA) showed positive A11 which had been reported to relate to Graves' disease, and positive DR4 which had been reported to relate to AIH and MCTD. These results suggested that HLA would determine susceptibility to three distinct autoimmune diseases in this case.

Thermolabile beta-2 macroglycoprotein is a novel serum protein that was detected by an autoantibody in sera of a Japanese woman with systemic lupus erythematosus. We developed an enzyme-linked immunosorbent assay for this glycoprotein and measured its serum levels in patients with chronic liver disease. There were significant correlations between serum levels of this glycoprotein and those of albumin and cholinesterase. The serum levels of TL beta 2MG decreased with increasing severity of cirrhosis. Immunohistochemical staining using monoclonal anti-thermolabile beta-2 macroglycoprotein antibody revealed positive staining in the cytoplasm of the hepatocytes. These data strongly suggested that hepatocyte may be one of the production sites of this glycoprotein. Measurement of serum levels of this glycoprotein was useful for evaluation of hepatic function in chronic liver disease.

Some pancreatic involvement was observed in Sjögren's syndrome (SS). Episodes of abdominal pain occurred infrequently in the course of SS, but there were some abnormal findings of the pancreatic functions and/or morphologic examinations. The level of serum amylase was affected by the destruction of both the pancreas and the salivary gland. Hyposecretion of bicarbonate in secretin test seemed to be characteristic in SS. ERP showed mild or moderate changes of the pancreatic duct, but their severities did not correlate with those of the salivary gland. Imaging of the pancreas tended to reveal definite abnormalities only in cases with an attack of pancreatitis. The roles of autoimmune mechanisms have been reported in pancreatitis associated with SS.

Here we report a rare case of simple hepatic cysts causing dilatation of the intrahepatic bile duct. A 75-year old female was admitted to Kyushu University Hospital because of liver dysfunction. Ultrasonogram and CT scan showed two neighboring cysts in the liver (S2, S4), and dilatation of the peripheral bile duct in left lateral segment of the liver. Echo-guided percutaneous aspiration of cyst fluid showed the elevated levels of CA19-9, but malignant cell were not seen. These findings suggested that the compression by these neighboring simple hepatic cysts caused the stenosis of the bile duct. The dilatation of the bile duct disappeared after the percutaneous ethanol sclerosing therapy for cyst.

A 78-year-old man was admitted to our hospital complaining of hypochondralgia. Since he was diagnosed as having advanced and unresectable hepatoma. UFT was administered as an oral chemotherapy, resulting in reduction of the liver tumor, and a decrease in AFP (ng/ml) from 1,200 to 18. Twenty-six months have already passed since the tumor was detected and 21 months since the start of UFT administration. The patient is still enjoying a good general condition and is presently under follow-up at our out-patient clinic. By the standard for the efficacy of cancer chemotherapy proposed by Koyama and Saito, this case corresponds to the state of complete response. This case suggested the clinical usefulness of UFT as an oral chemotherapy for advanced hepatoma.

The secretory and aggregation responses of stirred platelets exposed to complement proteins C5b-9 was investigated. C5b-9 assembly on the platelet surface resulted in the release of dense granule adenosine triphosphate (ATP) accompanied by a decrease in sample turbidity, but no detectable cell lysis. Inhibition of cellular protein kinase C completely blocked the C5b-9 initiated release of ATP, confirming the secretory nature of this response. Addition of fibrinogen (up to 1 mg/mL) had no effect on either the release of ATP or the decreased turbidity observed for C5b-9 cells. Addition of the peptides Arg-Gly-Asp-Ser (RGDS) and fibrinogen gamma-chain carboxyl-terminal (gamma 397-411) at concentrations sufficient to completely block fibrinogen binding to GP IIb-IIIa had no effect on either C5b-9 induced dense granule secretion or the associated turbidity change. Microscopic examination and electronic particle counting of the stirred platelet suspensions confirmed that no aggregation of C5b-9 platelets occurred even when these cells were stirred in the presence of fibrinogen. The capacity of the C5b-9 proteins to initiate platelet secretion without activation of cell surface glycoprotein (GP) IIb-IIIa suggests a mechanism for intravascular dissemination of activated platelets during complement activation in vivo.