1. Zebra Fish: Technology for Natural Product Discovery
- Author
-
R Hajiaghaee, Z Bagherzadeh, B Zarea, MA Faramarzi, and AR Shahverdi
- Subjects
zebra fish ,danio rerio ,natural products ,Therapeutics. Pharmacology ,RM1-950 ,Toxicology. Poisons ,RA1190-1270 - Abstract
Rising challenges in the present drug discovery model are prompting Prompt a renewed interest in natural products as a source of novel, bioactive small molecules. With the current validation of zebra fish as a biomedical appropriate model for functional genomics and in vivo drug discovery, the zebra fish bioassay-guided identification of natural products may be an attractive tactic to generate new lead compounds in a number of indication regions. Here, we review recent natural product research using zebra fish and evaluate the potential of this vertebrate model as a discovery platform for the systematic identification of bioactive natural products.
- Published
- 2009