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1. Psychiatric and physical outcomes of long-term use of lithium in older adults with bipolar disorder and major depressive disorder: A cross-sectional multicenter study

Author

Elise Morlet, Jean-François Costemale-Lacoste, Emmanuel Poulet, Kibby McMahon, Nicolas Hoertel, Frédéric Limosin, J Adès, C Alezrah, I Amado, G Amar, O Andréi, D Arbault, G Archambault, G Aurifeuille, S Barrière, C Béra-Potelle, Y Blumenstock, H Bardou, M Bareil-Guérin, P Barrau, C Barrouillet, E Baup, N Bazin, B Beaufils, J Ben Ayed, M Benoit, K Benyacoub, T Bichet, F Blanadet, O Blanc, J Blanc-Comiti, D Boussiron, AM Bouysse, A Brochard, O Brochart, B Bucheron, M Cabot, V Camus, JM Chabannes, V Charlot, T Charpeaud, C Clad-Mor, C Combes, M Comisu, B Cordier, F Costi, JP Courcelles, M Creixell, H Cuche, C Cuervo-Lombard, A Dammak, D Da Rin, JB Denis, H Denizot, A Deperthuis, E Diers, S Dirami, D Donneau, P Dreano, C Dubertret, E Duprat, D Duthoit, C Fernandez, P Fonfrede, N Freitas, P Gasnier, J Gauillard, F Getten, F Gierski, F Godart, R Gourevitch, A Grassin Delyle, J Gremion, H Gres, V Griner, C Guerin-Langlois, C Guggiari, O Guillin, H Hadaoui, E Haffen, C Hanon, S Haouzir, C Hazif-Thomas, A Heron, B Hubsch, I Jalenques, D Januel, A Kaladjian, JF Karnycheff, O Kebir, MO Krebs, C Lajugie, M Leboyer, P Legrand, M Lejoyeux, V Lemaire, E Leroy, D Levy-Chavagnat, A Leydier, C Liling, PM Llorca, P Loeffel, P Louville, S Lucas Navarro, N Mages, M Mahi, O Maillet, A Manetti, C Martelli, P Martin, M Masson, I Maurs-Ferrer, J Mauvieux, S Mazmanian, E Mechin, L Mekaoui, M Meniai, A Metton, A Mihoubi, M Miron, G Mora, V Niro Adès, P Nubukpo, C Omnes, S Papin, P Paris, C Passerieux, J Pellerin, J Perlbarg, S Perron, A Petit, F Petitjean, C Portefaix, D Pringuey, A Radtchenko, H Rahiou, D Raucher-Chéné, A Rauzy, L Reinheimer, M Renard, M René, CE Rengade, P Reynaud, D Robin, C Rodrigues, A Rollet, F Rondepierre, B Rousselot, S Rubingher, G Saba, JP Salvarelli, JC Samuelian, C Scemama-Ammar, F Schurhoff, JP Schuster, D Sechter, B Segalas, T Seguret, AS Seigneurie, A Semmak, F Slama, S Taisne, M Taleb, JL Terra, D Thefenne, E Tran, R Tourtauchaux, MN Vacheron, P Vandel, V Vanhoucke, E Venet, H Verdoux, A Viala, G Vidon, M Vitre, JL Vurpas, C Wagermez, M Walter, L Yon, X. Zendjidjian, Service de psychiatrie [Le Kremlin-Bicêtre], Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Centre Hospitalier le Vinatier [Bron], Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), PELLENC S.A., Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire d'Informatique Fondamentale de Lille (LIFL), Université de Lille, Sciences et Technologies-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lille, Sciences Humaines et Sociales-Centre National de la Recherche Scientifique (CNRS), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), French Society for Biological Psychiatry and Neuropsychopharmacology, Partenaires INRAE, Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), Département d'Astrophysique (ex SAP) (DAP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Università degli studi di Genova = University of Genoa (UniGe), Fondation FondaMental [Créteil], Fédération Française de Triathlon (FFTRI), Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Cognition, Santé, Société (C2S), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA)-Maison des Sciences Humaines de Champagne-Ardenne (MSH-URCA), Université de Reims Champagne-Ardenne (URCA), Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481) (NEURO), Université de Franche-Comté (UFC), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service hospitalo-universitaire, centre hospitalier du Rouvray, 4, rue Paul-Eluard, 76300 Sotteville-lès-Rouen, France., CHRU Brest - Psychiatrie Adulte (CHU - Brest- Psychiatrie), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre de Physique Théorique [Palaiseau] (CPHT), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centres d'addictologies - Région Centre, CHU Clermont-Ferrand, Unité de recherche clinique 93G03, établissement public de santé de Ville Evrard, 93330 Neuilly-sur-Marne, France., Laboratoire de Physique des Lasers (LPL), Université Paris 13 (UP13)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Sonatrach Exploration, Monash University [Clayton], Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804 (CRESTIC), Clinique de Psychiatrie et de Psychologie Médicale, Hôpital Pasteur, Nice, France, Centre Hospitalier Universitaire de Nice (CHU Nice), Department of Engineering Cybernetics [Trondheim] (ITK NTNU), Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU)-Norwegian University of Science and Technology (NTNU), Jeune Equipe Hémopathogènes Vectorisés, VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Silicon-on-Insulator Technologies (SOITEC), Parc Technologique des Fontaines, Recherches en Psychopathologie, nouveaux symptômes et lien social (EA 4050), Université de Poitiers-Université de Brest (UBO)-Université Catholique de l'Ouest (UCO)-Université de Rennes 2 (UR2), Agriculture et forêt méditerranéenne (UR AFAX), Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF), Kantar – Health Division, Institut National de Recherche en Génie Rural Eaux et Forêts (INRGREF), Ecole Nationale du Génie Rural, des Eaux et des Forêts (ENGREF)-Institution de la Recherche et de l'Enseignement Supérieur Agricoles [Tunis] (IRESA), Département de psychiatrie [CHRU de Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Pôle Universitaire de Psychiatrie Adulte, Différenciation et communication neuronale et neuroendocrine (DC2N), Centre de Psychiatrie et Neurosciences (U894), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC), Dipartimento di Scienze della Terra, Universita degli studi di Genova, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Maison des Sciences Humaines de Champagne-Ardenne (MSH-URCA), Laboratoire de Neurosciences Intégratives et Cliniques - UFC (EA 481) (NEURO), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Belfort-Montbeliard (UTBM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université Fédérale Toulouse Midi-Pyrénées

Subjects
Male, Aging, medicine.medical_specialty, Bipolar Disorder, Lithium (medication), Population, [SHS.PSY]Humanities and Social Sciences/Psychology, Comorbidity, [SHS]Humanities and Social Sciences, law.invention, Benzodiazepines, Depressive Disorder, Treatment-Resistant, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, medicine, Humans, Bipolar disorder, education, Psychiatry, ComputingMilieux_MISCELLANEOUS, Aged, Depressive Disorder, Major, education.field_of_study, Depression, business.industry, Middle Aged, medicine.disease, Antidepressive Agents, 3. Good health, 030227 psychiatry, Hospitalization, Psychiatry and Mental health, Clinical Psychology, Cross-Sectional Studies, Mood disorders, Tolerability, Schizophrenia, Lithium Compounds, Major depressive disorder, Female, business, 030217 neurology & neurosurgery, Antipsychotic Agents, medicine.drug
Abstract

Although lithium is widely used in current practice to treat bipolar disorder (BD) and treatment-resistant major depressive disorder (MDD) among older adults, little is known about its efficacy and tolerability in this population, which is generally excluded from randomized clinical trials. The objective of this study was to evaluate the efficacy and tolerability of long-term use of lithium among older adults with BD and MDD.Data from the Cohort of individuals with Schizophrenia and mood disorders Aged 55 years or more (CSA) were used. Two groups of patients with BD and MDD were compared: those who were currently receiving lithium versus those who were not. The effects of lithium on psychiatric (i.e., depressive symptoms severity, perceived clinical severity, rates of psychiatric admissions in the past-year), geriatric (overall and cognitive functioning) and physical outcomes (i.e., rates of non-psychiatric medical comorbidities and general hospital admissions in the past-year) were evaluated. All analyses were adjusted for age, sex, duration of disorder, diagnosis, smoking status, alcohol use, and use of antipsychotics, antiepileptics or antidepressants.Among the 281 older participants with BD or MDD, 15.7% were taking lithium for a mean duration of 12.5(SD = 11.6) years. Lithium use was associated with lower intensity of depressive symptoms, reduced perceived clinical global severity and lower benzodiazepine use (all p 0.05), without being linked to greater rates of medical comorbidities, except for hypothyroidism.Data were cross-sectional and data on lifetime history of psychotropic medications was not assessed.Our results suggest that long-term lithium use may be efficient and relatively well-tolerated in older adults with BD or treatment-resistant MDD.

Published
2019

2. Difficulties identifying feelings, alexithymic features and brain responses in social phobia trait: an fMRI study

Author

Céline Béra-Potelle, Frédéric Limosin, Christophe Portefaix, B. Hubsch, Arthur Kaladjian, Fabien Gierski, Laurent Pierot, E. Tran, Arnaud Carre, and Chrystel Besche-Richard

Subjects
medicine.diagnostic_test, media_common.quotation_subject, Social anxiety, Liebowitz social anxiety scale, Anger, medicine.disease, Shyness, behavioral disciplines and activities, Developmental psychology, Sadness, Psychiatry and Mental health, Toronto Alexithymia Scale, Alexithymia, medicine, Anxiety, medicine.symptom, Psychology, media_common
Abstract

AimsA growing body of research now documents a specific pattern of brain activation during emotional tasks in patients with social phobia. Furthermore, recent studies indicate that non-clinical participants show a similar pattern of responses. Clinical and physiological data from literature highlight that social anxiety is associated with difficulties in emotional managing. However, much less is known about the part of alexithymia in social phobia, as far as clinical and infra-clinical (high shyness) approaches are concerned.MethodFour hundred undergraduate university students were screened with an anxiety and social phobia questionnaire. Forty participants, with low and high levels of social phobia, were then included according to a dimensional approach. Each participant underwent a comprehensive psychiatric evaluation that included a structured clinical interview for current and past psychiatric disorders and psychometric scales, including the Liebowitz Social Anxiety Scale (LSAS) and the Toronto Alexithymia Scale (TAS-20). Participants were asked to make gender discrimination choices when viewing faces that showed happiness, fear, anger, sadness, neutral expressions or distractors while in a 3 Tesla fMRI scanner.ResultsAs expected, social phobia trait was correlated with TAS-20 scores, and specifically in “difficulties identifying feelings”. Brain activations showed an evolutionary pattern response in correlation with social phobia and alexithymia concerning limbic regions (amygdala and insula). Social phobia trait seems to be particularly receptive to anger faces.ConclusionOur findings support the hypothesis that alexithymia play a major role in social anxiety disorder. Identifying feelings could explain alexithymic functioning in social phobia, clinically and physiologically.

Published
2011

3. Impulsiveness and Neuropsychological Performance in First Degree Relatives of Patients with Alcohol Dependence

Author

Frédéric Limosin, Fabien Gierski, Arnaud Carre, Christine-Vanessa Cuervo-Lombard, and B. Hubsch-Sonntag

Subjects
medicine.medical_specialty, education.field_of_study, Alcohol dependence, Population, Neuropsychology, Impulsivity, Psychiatry and Mental health, Barratt Impulsiveness Scale, Wisconsin Card Sorting Test, medicine, First-degree relatives, medicine.symptom, Psychiatry, Psychology, education, Clinical psychology, Stroop effect
Abstract

Aims:It is now well known that unaffected first-degree relatives of patients with alcohol disorder have electrophysiological abnormalities (less P3 amplitude). These abnormalities are associated with higher scores in impulsivity self-rating scales and are assumed to reflect central nervous system disinhibition and/or hyperexcitability. However very much less is known about the performance of this population in neuropsychological tests assessing executive functioning and in particular the inhibition process.Method:Thirty-five first-degree relatives of patients with alcohol dependence were compared to thirty-five healthy controls, matched in terms of age, gender and education level. They completed a self-rating scale of impulsiveness (Barratt Impulsiveness Scale) and a battery of neuropsychological tests. The test battery included the Wisconsin Card Sorting Test, a measure of overall executive functioning, and two performance measures of inhibition process (a Stroop task and a Go-No Go task).Results:As expected, the Barratt Impulsiveness Scale showed differences between the two groups, with first-degree relatives having higher overall scores and increased scores in the non-planning subscale. Results from neuropsychological testing indicated significant differences among the three tasks (WCST, Stroop task and Go-No Go).Conclusion:Our findings are consistent with the view that unaffected first-degree relatives of patients with alcohol dependence show decrements in executive functioning and inhibition process. Studies are underway to identify genes associated with the underlying predisposition involved in disinhibitory disorders in this population.

Published
2009

4. Executive functions in adult offspring of alcohol-dependent probands: toward a cognitive endophenotype?

Author

Gierski F, Hubsch B, Stefaniak N, Benzerouk F, Cuervo-Lombard C, Bera-Potelle C, Cohen R, Kahn JP, and Limosin F

Subjects
Adolescent, Adult, Alcoholism epidemiology, Alcoholism psychology, Cognition Disorders epidemiology, Cognition Disorders psychology, Female, Humans, Male, Middle Aged, Young Adult, Adult Children psychology, Alcoholism genetics, Cognition Disorders genetics, Endophenotypes, Executive Function physiology, Neuropsychological Tests
Abstract

Background: Executive function (EF) impairment in alcohol dependence (AD) has been related to the toxic effects of alcohol on frontal lobes. However, this impairment could be partially present before the onset of the disease and might constitute a vulnerability factor. Although a considerable body of research has investigated executive functioning among AD patients, much less attention has been directed toward high-risk individuals. Most studies were carried out among children or adolescents, and very few were conducted in adults. The aim of this study was to examine EF in a group of adult offspring of AD individuals., Methods: One hundred and fifty-five nonalcoholic adults with (family history positive [FHP]) or without (family history negative [FHN]) family history of AD were included in the study. All participants were screened for past and current psychiatric diagnoses, and alcohol, tobacco, and other substance use. They were compared on self-rated impulsiveness using the Barratt Impulsiveness Scale-11 (BIS-11) and EF using a neuropsychological test battery., Results: Group comparison revealed that FHP participants had significantly higher BIS-11 scores than the FHN participants, while neuropsychological examination revealed lower EF scores for FHP participants. Hierarchical regression analysis revealed that the number of AD family members was a predictor of EF results, whereas impulsiveness was not., Conclusions: Nonalcoholic adult offspring of AD individuals showed increased impulsiveness and decreased EF, suggesting weakness of 2 distinct neurobehavioral decision systems. Findings support evidence that EF weaknesses may qualify as a suitable endophenotype candidate for AD., (Copyright © 2012 by the Research Society on Alcoholism.)

Published
2013
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