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1,348 results on '"Büller, Harry R"'

1. Risk assessment tools for bleeding in patients with unprovoked venous thromboembolism: an analysis of the PLATO-VTE study

Author

Guman, Noori A.M., Becking, Anne-Marie L., Weijers, Suzanne S., Kraaijpoel, Noémie, Mulder, Frits I., Carrier, Marc, Jara-Palomares, Luis, Di Nisio, Marcello, Ageno, Walter, Beyer-Westendorf, Jan, Klok, Frederikus A., Vanassche, Thomas, Otten, Johannes M.M.B., Cosmi, Benilde, Peters, Mike J.L., Wolde, Marije ten, Delluc, Aurélien, Sanchez-Lopez, Veronica, Porreca, Ettore, Bossuyt, Patrick M.M., Gerdes, Victor E.A., Büller, Harry R., van Es, Nick, and Kamphuisen, Pieter W.

Published
2024
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5. Inhibition of thrombin-activatable fibrinolysis inhibitor via DS-1040 to accelerate clot lysis in patients with acute pulmonary embolism: a randomized phase 1b study

Author

Huisman, Menno, Tapson, Victor, Grosso, Michael, Segers, Annelise, Ageno, Walter, Brodmann, Marianne, Jimenez, David, Meyer, Guy, Middeldorp, Saskia, Rosovsky, Rachel, Schellong, Sebastian, Verhamme, Peter, Büller, Harry, Bossuyt, Patrick, van Es, Nick, Vanassche, Thomas, Rosovsky, Rachel P., Moustafa, Fares, Büller, Harry R., Patel, Indu, Shi, Minggao, Miyoshi, Naoki, Mani, Venkatesh, Fayad, Zahi, Stephan, Dominique, Schmidt, Jeannot, Grosso, Michael A., Tapson, Victor F., and Huisman, Menno V.

Published
2023
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6. Platelet RNA sequencing for cancer screening in patients with unprovoked venous thromboembolism: a prospective cohort study

Author

Mulder, Frits I., Kraaijpoel, Noémie, Carrier, Marc, Guman, Noori A., Jara-Palomares, Luis, Di Nisio, Marcello, Ageno, Walter, Beyer-Westendorf, Jan, Klok, Frederikus A., Vanassche, Thomas, Otten, Hans-Martin B., Cosmi, Benilde, Wolde, Marije ten, In ‘t Veld, Sjors G.J. G., Post, Edward, Ramaker, Jip, Zwaan, Kenn, Peters, Mike, Delluc, Aurélien, Kamphuisen, Pieter W., Sanchez-Lopez, Veronica, Porreca, Ettore, Bossuyt, Patrick M.M., Büller, Harry R., Wurdinger, Thomas, Best, Myron G., and van Es, Nick

Published
2023
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8. Evaluation of the Khorana, PROTECHT, and 5‐SNP scores for prediction of venous thromboembolism in patients with cancer

Author

Guman, Noori A.M., van Geffen, Roos J., Mulder, Frits I., van Haaps, Thijs F., Hovsepjan, Vahram, Labots, Mariette, Cirkel, Geert A., de Vos, Filip Y.F.L., Ten Tije, Albert J., Beerepoot, Laurens V., Tjan‐Heijnen, Vivianne C.G., van Laarhoven, Hanneke W.M., Hamberg, Paul, Vulink, Annelie J.E., Los, Maartje, Zwinderman, Aeilko H., Ferwerda, Bart, Lolkema, Martijn P.J.K., Steeghs, Neeltje, Büller, Harry R., Kamphuisen, Pieter W., and van Es, Nick

Published
2021
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11. Long‐term risk of recurrent venous thromboembolism among patients receiving extended oral anticoagulant therapy for first unprovoked venous thromboembolism: A systematic review and meta‐analysis

Author

Khan, Faizan, Tritschler, Tobias, Kimpton, Miriam, Wells, Philip S., Kearon, Clive, Weitz, Jeffrey I., Büller, Harry R., Raskob, Gary E., Ageno, Walter, Couturaud, Francis, Prandoni, Paolo, Palareti, Gualtiero, Legnani, Cristina, Kyrle, Paul A., Eichinger, Sabine, Eischer, Lisbeth, Becattini, Cecilia, Agnelli, Giancarlo, Vedovati, Maria Cristina, Geersing, Geert‐Jan, Takada, Toshihiko, Cosmi, Benilde, Aujesky, Drahomir, Marconi, Letizia, Palla, Antonio, Siragusa, Sergio, Bradbury, Charlotte A., Parpia, Sameer, Mallick, Ranjeeta, Lensing, Anthonie W.A., Gebel, Martin, Grosso, Michael A., Shi, Minggao, Thavorn, Kednapa, Hutton, Brian, Le Gal, Gregoire, Rodger, Marc, and Fergusson, Dean

Published
2021
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14. Heavy menstrual bleeding on direct factor Xa inhibitors: Rationale and design of the MEDEA study

Author

Hamulyák, Eva N., Wiegers, Hanke M.G., Scheres, Luuk J.J., Hutten, Barbara A., de Lange, Maria E., Timmermans, Anne, Westerweel, Peter E., Nijziel, Marten R., Kruip, Marieke J.H.A., ten Wolde, Marije, Ypma, Paula F., Klok, Frederikus A., Nieuwenhuizen, Laurens, van Wissen, Sanne, Hovens, Marcel M.C., Faber, Laura M., Kamphuisen, Pieter W., Büller, Harry R., and Middeldorp, Saskia

Published
2021
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15. Risk assessment tools for bleeding in patients with unprovoked venous thromboembolism: an analysis of the PLATO-VTE study

Author

MS Geriatrie, Guman, Noori A.M., Becking, Anne Marie L., Weijers, Suzanne S., Kraaijpoel, Noémie, Mulder, Frits I., Carrier, Marc, Jara-Palomares, Luis, Di Nisio, Marcello, Ageno, Walter, Beyer-Westendorf, Jan, Klok, Frederikus A., Vanassche, Thomas, Otten, Johannes M.M.B., Cosmi, Benilde, Peters, Mike J.L., Wolde, Marije ten, Delluc, Aurélien, Sanchez-Lopez, Veronica, Porreca, Ettore, Bossuyt, Patrick M.M., Gerdes, Victor E.A., Büller, Harry R., van Es, Nick, Kamphuisen, Pieter W., MS Geriatrie, Guman, Noori A.M., Becking, Anne Marie L., Weijers, Suzanne S., Kraaijpoel, Noémie, Mulder, Frits I., Carrier, Marc, Jara-Palomares, Luis, Di Nisio, Marcello, Ageno, Walter, Beyer-Westendorf, Jan, Klok, Frederikus A., Vanassche, Thomas, Otten, Johannes M.M.B., Cosmi, Benilde, Peters, Mike J.L., Wolde, Marije ten, Delluc, Aurélien, Sanchez-Lopez, Veronica, Porreca, Ettore, Bossuyt, Patrick M.M., Gerdes, Victor E.A., Büller, Harry R., van Es, Nick, and Kamphuisen, Pieter W.

Published
2024

18. Evaluating prophylactic heparin in ambulatory patients with solid tumours: a systematic review and individual participant data meta-analysis

Author

Schünemann, Holger J, Ventresca, Matthew, Crowther, Mark, Briel, Matthias, Zhou, Qi, Noble, Simon, Macbeth, Fergus, Griffiths, Gareth, Garcia, David, Lyman, Gary H, Di Nisio, Marcello, Iorio, Alfonso, Mbuagbaw, Lawrence, Neumann, Ignacio, van Es, Nick, Brouwers, Melissa, Guyatt, Gordon, Streiff, Michael B, Marcucci, Maura, Baldeh, Tejan, Florez, Ivan D, Alma, Ozlem Gurunlu, Solh, Ziad, Bossuyt, Patrick M, Kahale, Lara A, Ageno, Walter, Bozas, George, Büller, Harry R, Lebeau, Bernard, Lecumberri, Ramon, Loprinzi, Charles, McBane, Robert, Sideras, Kostandinos, Maraveyas, Anthony, Pelzer, Uwe, Perry, James, Klerk, Clara, Agnelli, Giancarlo, and Akl, Elie A

Published
2020
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20. The Khorana score for prediction of venous thromboembolism in cancer patients: An individual patient data meta‐analysis

Author

van Es, Nick, Ventresca, Matthew, Di Nisio, Marcello, Zhou, Qi, Noble, Simon, Crowther, Mark, Briel, Matthias, Garcia, David, Lyman, Gary H., Macbeth, Fergus, Griffiths, Gareth, Iorio, Alfonso, Mbuagbaw, Lawrence, Neumann, Ignacio, Brozek, Jan, Guyatt, Gordon, Streiff, Michael B., Baldeh, Tejan, Florez, Ivan D., Gurunlu Alma, Ozlem, Agnelli, Giancarlo, Ageno, Walter, Marcucci, Maura, Bozas, George, Zulian, Gilbert, Maraveyas, Anthony, Lebeau, Bernard, Lecumberri, Ramon, Sideras, Kostandinos, Loprinzi, Charles, McBane, Robert, Pelzer, Uwe, Riess, Hanno, Solh, Ziad, Perry, James, Kahale, Lara A., Bossuyt, Patrick M., Klerk, Clara, Büller, Harry R., Akl, Elie A., and Schünemann, Holger J.

Published
2020
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22. Long term risk of symptomatic recurrent venous thromboembolism after discontinuation of anticoagulant treatment for first unprovoked venous thromboembolism event : systematic review and meta-analysis

Author

MARVELOUS Collaborators, Khan, Faizan, Rahman, Alvi, Carrier, Marc, Kearon, Clive, Weitz, Jeffrey I, Schulman, Sam, Couturaud, Francis, Eichinger, Sabine, Kyrle, Paul A, Becattini, Cecilia, Agnelli, Giancarlo, Brighton, Timothy A, Lensing, Anthonie W A, Prins, Martin H, Sabri, Elham, Hutton, Brian, Pinede, Laurent, Cushman, Mary, Palareti, Gualtiero, Wells, George A, Prandoni, Paolo, Büller, Harry R, and Rodger, Marc A

Published
2019

26. Ruling out pulmonary embolism across different healthcare settings: A systematic review and individual patient data meta-analysis

Author

Geersing, Geert-Jan, Takada, Toshihiko, Klok, Frederikus A., Büller, Harry R., Courtney, D. Mark, Freund, Yonathan, Galipienzo, Javier, Le Gal, Gregoire, Ghanima, Waleed, Kline, Jeffrey A., Huisman, Menno V., Moons, Karel G. M., Perrier, Arnaud, Parpia, Sameer, Robert-Ebadi, Helia, Righini, Marc, Roy, Pierre-Marie, van Smeden, Maarten, Stals, Milou A. M., Wells, Philip S., de Wit, Kerstin, Kraaijpoel, Noémie, and van Es, Nick

Subjects
Pulmonary embolism -- Diagnosis, Diagnosis -- Comparative analysis -- Evaluation, Biological sciences
Abstract

Background The challenging clinical dilemma of detecting pulmonary embolism (PE) in suspected patients is encountered in a variety of healthcare settings. We hypothesized that the optimal diagnostic approach to detect these patients in terms of safety and efficiency depends on underlying PE prevalence, case mix, and physician experience, overall reflected by the type of setting where patients are initially assessed. The objective of this study was to assess the capability of ruling out PE by available diagnostic strategies across all possible settings. Methods and findings We performed a literature search (MEDLINE) followed by an individual patient data (IPD) meta-analysis (MA; 23 studies), including patients from self-referral emergency care (n = 12,612), primary healthcare clinics (n = 3,174), referred secondary care (n = 17,052), and hospitalized or nursing home patients (n = 2,410). Multilevel logistic regression was performed to evaluate diagnostic performance of the Wells and revised Geneva rules, both using fixed and adapted D-dimer thresholds to age or pretest probability (PTP), for the YEARS algorithm and for the Pulmonary Embolism Rule-out Criteria (PERC). All strategies were tested separately in each healthcare setting. Following studies done in this field, the primary diagnostic metrices estimated from the models were the 'failure rate' of each strategy-i.e., the proportion of missed PE among patients categorized as 'PE excluded' and 'efficiency'-defined as the proportion of patients categorized as 'PE excluded' among all patients. In self-referral emergency care, the PERC algorithm excludes PE in 21% of suspected patients at a failure rate of 1.12% (95% confidence interval [CI] 0.74 to 1.70), whereas this increases to 6.01% (4.09 to 8.75) in referred patients to secondary care at an efficiency of 10%. In patients from primary healthcare and those referred to secondary care, strategies adjusting D-dimer to PTP are the most efficient (range: 43% to 62%) at a failure rate ranging between 0.25% and 3.06%, with higher failure rates observed in patients referred to secondary care. For this latter setting, strategies adjusting D-dimer to age are associated with a lower failure rate ranging between 0.65% and 0.81%, yet are also less efficient (range: 33% and 35%). For all strategies, failure rates are highest in hospitalized or nursing home patients, ranging between 1.68% and 5.13%, at an efficiency ranging between 15% and 30%. The main limitation of the primary analyses was that the diagnostic performance of each strategy was compared in different sets of studies since the availability of items used in each diagnostic strategy differed across included studies; however, sensitivity analyses suggested that the findings were robust. Conclusions The capability of safely and efficiently ruling out PE of available diagnostic strategies differs for different healthcare settings. The findings of this IPD MA help in determining the optimum diagnostic strategies for ruling out PE per healthcare setting, balancing the trade-off between failure rate and efficiency of each strategy., Author(s): Geert-Jan Geersing 1,*, Toshihiko Takada 1,2, Frederikus A. Klok 3, Harry R. Büller 4, D. Mark Courtney 5, Yonathan Freund 6, Javier Galipienzo 7, Gregoire Le Gal 8, Waleed [...]

Published
2022
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28. Diagnostic management of acute pulmonary embolism: a prediction model based on a patient data meta-analysis

Author

van Es, Nick, primary, Takada, Toshihiko, additional, Kraaijpoel, Noémie, additional, Klok, Frederikus A, additional, Stals, Milou A M, additional, Büller, Harry R, additional, Courtney, D Mark, additional, Freund, Yonathan, additional, Galipienzo, Javier, additional, Le Gal, Grégoire, additional, Ghanima, Waleed, additional, Huisman, Menno V, additional, Kline, Jeffrey A, additional, Moons, Karel G M, additional, Parpia, Sameer, additional, Perrier, Arnaud, additional, Righini, Marc, additional, Robert-Ebadi, Helia, additional, Roy, Pierre-Marie, additional, Wells, Phil S, additional, de Wit, Kerstin, additional, van Smeden, Maarten, additional, and Geersing, Geert-Jan, additional

Published
2023
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29. Covariate-specific ROC curve analysis can accommodate differences between covariate subgroups in the evaluation of diagnostic accuracy

Author

Lee, Jenny, primary, van Es, Nick, additional, Takada, Toshihiko, additional, Klok, Frederikus A., additional, Geersing, Geert-Jan, additional, Blume, Jeffrey, additional, Bossuyt, Patrick M., additional, Büller, Harry R., additional, Courtney, D Mark, additional, Freund, Yonathan, additional, Galipienzo, Javier, additional, Le Gal, Gregoire, additional, Ghanima, Waleed, additional, Kline, Jeffrey A., additional, Huisman, Menno V., additional, Moons, Karel G.M., additional, Perrier, Arnaud, additional, Parpia, Sameer, additional, Robert-Ebadi, Helia, additional, Righini, Marc, additional, Roy, Pierre-Marie, additional, van Smeden, Maarten, additional, Stals, Milou A.M., additional, Wells, Philip S., additional, de Wit, Kerstin, additional, and Kraaijpoel, Noémie, additional

Published
2023
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32. Treatment of Cancer-Associated Thrombosis: Recent Advances, Unmet Needs, and Future Direction

Author

Wang, Tzu-Fei, primary, Khorana, Alok A, additional, Agnelli, Giancarlo, additional, Bloomfield, Dan, additional, Bonaca, Marc P, additional, Büller, Harry R, additional, Connors, Jean M, additional, Goto, Shinya, additional, Jing, Zhi-Cheng, additional, Kakkar, Ajay K, additional, Khder, Yasser, additional, Raskob, Gary E, additional, Soff, Gerald A, additional, Verhamme, Peter, additional, Weitz, Jeffrey I, additional, and Carrier, Marc, additional

Published
2023
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33. Diagnostic management of acute pulmonary embolism: a prediction model based on a patient data meta-analysis

Author

HAG Trombose, Epi Methoden, Cancer, JC onderzoeksprogramma Methodologie, Epi Methoden Team 3, Infection & Immunity, Circulatory Health, van Es, Nick, Takada, Toshihiko, Kraaijpoel, Noémie, Klok, Frederikus A, Stals, Milou A M, Büller, Harry R, Courtney, D Mark, Freund, Yonathan, Galipienzo, Javier, Le Gal, Grégoire, Ghanima, Waleed, Huisman, Menno V, Kline, Jeffrey A, Moons, Karel G M, Parpia, Sameer, Perrier, Arnaud, Righini, Marc, Robert-Ebadi, Helia, Roy, Pierre-Marie, Wells, Phil S, de Wit, Kerstin, van Smeden, Maarten, Geersing, Geert-Jan, HAG Trombose, Epi Methoden, Cancer, JC onderzoeksprogramma Methodologie, Epi Methoden Team 3, Infection & Immunity, Circulatory Health, van Es, Nick, Takada, Toshihiko, Kraaijpoel, Noémie, Klok, Frederikus A, Stals, Milou A M, Büller, Harry R, Courtney, D Mark, Freund, Yonathan, Galipienzo, Javier, Le Gal, Grégoire, Ghanima, Waleed, Huisman, Menno V, Kline, Jeffrey A, Moons, Karel G M, Parpia, Sameer, Perrier, Arnaud, Righini, Marc, Robert-Ebadi, Helia, Roy, Pierre-Marie, Wells, Phil S, de Wit, Kerstin, van Smeden, Maarten, and Geersing, Geert-Jan

Published
2023

34. Redefining clinical venous thromboembolism phenotypes: a novel approach using latent class analysis

Author

MS Interne Geneeskunde, Cardiovasculaire Epi Team 7B, Epi Infectieziekten, Circulatory Health, Medische Staf Spoedeisende Hulp, de Winter, Maria A., Uijl, Alicia, Büller, Harry R., Carrier, Marc, Cohen, Alexander T., Hansen, John Bjarne, Kaasjager, Karin H.A.H., Kakkar, Ajay K., Middeldorp, Saskia, Raskob, Gary E., Sørensen, Henrik Toft, Wells, Philip S., Nijkeuter, Mathilde, Dorresteijn, Jannick A.N., MS Interne Geneeskunde, Cardiovasculaire Epi Team 7B, Epi Infectieziekten, Circulatory Health, Medische Staf Spoedeisende Hulp, de Winter, Maria A., Uijl, Alicia, Büller, Harry R., Carrier, Marc, Cohen, Alexander T., Hansen, John Bjarne, Kaasjager, Karin H.A.H., Kakkar, Ajay K., Middeldorp, Saskia, Raskob, Gary E., Sørensen, Henrik Toft, Wells, Philip S., Nijkeuter, Mathilde, and Dorresteijn, Jannick A.N.

Published
2023

35. Recurrent venous thromboembolism and bleeding with extended anticoagulation: the VTE-PREDICT risk score

Author

MS Interne Geneeskunde, Epi Infectieziekten, Circulatory Health, Interne Geneeskunde Vasculaire, Medische Staf Spoedeisende Hulp, De Winter, Maria A., Büller, Harry R., Carrier, Marc, Cohen, Alexander T., Hansen, John Bjarne, Kaasjager, Karin A.H., Kakkar, Ajay K., Middeldorp, Saskia, Raskob, Gary E., Sørensen, Henrik T., Visseren, Frank L.J., Wells, Philip S., Dorresteijn, Jannick A.N., Nijkeuter, Mathilde, Braekkan, Sigrid K., Burggraaf, Louise, Cannegieter, Suzanne C., Farjat, Alfredo, Pap, Akos Ferenc, Goldhaber, Samuel, Grosso, Michael, Horváth-Puhó, Erzsebet, Lensing, Anthonie W.A., Pieper, Karen, Schulman, Sam, Shi, Minggao, Virdone, Saverio, MS Interne Geneeskunde, Epi Infectieziekten, Circulatory Health, Interne Geneeskunde Vasculaire, Medische Staf Spoedeisende Hulp, De Winter, Maria A., Büller, Harry R., Carrier, Marc, Cohen, Alexander T., Hansen, John Bjarne, Kaasjager, Karin A.H., Kakkar, Ajay K., Middeldorp, Saskia, Raskob, Gary E., Sørensen, Henrik T., Visseren, Frank L.J., Wells, Philip S., Dorresteijn, Jannick A.N., Nijkeuter, Mathilde, Braekkan, Sigrid K., Burggraaf, Louise, Cannegieter, Suzanne C., Farjat, Alfredo, Pap, Akos Ferenc, Goldhaber, Samuel, Grosso, Michael, Horváth-Puhó, Erzsebet, Lensing, Anthonie W.A., Pieper, Karen, Schulman, Sam, Shi, Minggao, and Virdone, Saverio

Published
2023

39. Redefining clinical venous thromboembolism phenotypes: a novel approach using latent class analysis

Author

de Winter, Maria A., primary, Uijl, Alicia, additional, Büller, Harry R., additional, Carrier, Marc, additional, Cohen, Alexander T., additional, Hansen, John-Bjarne, additional, Kaasjager, Karin (H.A.H.), additional, Kakkar, Lord Ajay K., additional, Middeldorp, Saskia, additional, Raskob, Gary E., additional, Sørensen, Henrik Toft, additional, Wells, Philip S., additional, Nijkeuter, Mathilde, additional, and Dorresteijn, Jannick A.N., additional

Published
2022
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44. Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism

Author

Raskob, Gary E., van Es, Nick, Verhamme, Peter, Carrier, Marc, Di Nisio, Marcello, Garcia, David, Grosso, Michael A., Kakkar, Ajay K., Kovacs, Michael J., Mercuri, Michele F., Meyer, Guy, Segers, Annelise, Shi, Minggao, Wang, Tzu-Fei, Yeo, Erik, Zhang, George, Zwicker, Jeffrey I., Weitz, Jeffrey I., and Büller, Harry R.

Published
2018
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45. Diagnostic management of acute pulmonary embolism: a prediction model based on a patient data meta-analysis.

Author

Es, Nick van, Takada, Toshihiko, Kraaijpoel, Noémie, Klok, Frederikus A, Stals, Milou A M, Büller, Harry R, Courtney, D Mark, Freund, Yonathan, Galipienzo, Javier, Gal, Grégoire Le, Ghanima, Waleed, Huisman, Menno V, Kline, Jeffrey A, Moons, Karel G M, Parpia, Sameer, Perrier, Arnaud, Righini, Marc, Robert-Ebadi, Helia, Roy, Pierre-Marie, and Wells, Phil S

Subjects
PULMONARY embolism, CLINICAL prediction rules, NURSING home residents, PREDICTION models, VENOUS thrombosis, THROMBOEMBOLISM, SYMPTOMS
Abstract

Aims Risk stratification is used for decisions regarding need for imaging in patients with clinically suspected acute pulmonary embolism (PE). The aim was to develop a clinical prediction model that provides an individualized, accurate probability estimate for the presence of acute PE in patients with suspected disease based on readily available clinical items and D-dimer concentrations. Methods and results An individual patient data meta-analysis was performed based on sixteen cross-sectional or prospective studies with data from 28 305 adult patients with clinically suspected PE from various clinical settings, including primary care, emergency care, hospitalized and nursing home patients. A multilevel logistic regression model was built and validated including ten a priori defined objective candidate predictors to predict objectively confirmed PE at baseline or venous thromboembolism (VTE) during follow-up of 30 to 90 days. Multiple imputation was used for missing data. Backward elimination was performed with a P -value <0.10. Discrimination (c-statistic with 95% confidence intervals [CI] and prediction intervals [PI]) and calibration (outcome:expected [O:E] ratio and calibration plot) were evaluated based on internal-external cross-validation. The accuracy of the model was subsequently compared with algorithms based on the Wells score and D-dimer testing. The final model included age (in years), sex, previous VTE, recent surgery or immobilization, haemoptysis, cancer, clinical signs of deep vein thrombosis, inpatient status, D-dimer (in µg/L), and an interaction term between age and D-dimer. The pooled c-statistic was 0.87 (95% CI, 0.85–0.89; 95% PI, 0.77–0.93) and overall calibration was very good (pooled O:E ratio, 0.99; 95% CI, 0.87–1.14; 95% PI, 0.55–1.79). The model slightly overestimated VTE probability in the lower range of estimated probabilities. Discrimination of the current model in the validation data sets was better than that of the Wells score combined with a D-dimer threshold based on age (c-statistic 0.73; 95% CI, 0.70–0.75) or structured clinical pretest probability (c-statistic 0.79; 95% CI, 0.76–0.81). Conclusion The present model provides an absolute, individualized probability of PE presence in a broad population of patients with suspected PE, with very good discrimination and calibration. Its clinical utility needs to be evaluated in a prospective management or impact study. Registration PROSPERO ID 89366. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Ruling out pulmonary embolism across different healthcare settings: A systematic review and individual patient data meta-analysis

Author

HAG Trombose, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epi Methoden, Cancer, JC onderzoeksprogramma Methodologie, Epi Methoden Team 3, Infection & Immunity, Geersing, Geert Jan, Takada, Toshihiko, Klok, Frederikus A., Büller, Harry R., Courtney, D. Mark, Freund, Yonathan, Galipienzo, Javier, Le Gal, Gregoire, Ghanima, Waleed, Kline, Jeffrey A., Huisman, Menno V., Moons, Karel G.M., Perrier, Arnaud, Parpia, Sameer, Robert-Ebadi, Helia, Righini, Marc, Roy, Pierre Marie, van Smeden, Maarten, Stals, Milou A.M., Wells, Philip S., de Wit, Kerstin, Kraaijpoel, Noémie, van Es, Nick, HAG Trombose, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epi Methoden, Cancer, JC onderzoeksprogramma Methodologie, Epi Methoden Team 3, Infection & Immunity, Geersing, Geert Jan, Takada, Toshihiko, Klok, Frederikus A., Büller, Harry R., Courtney, D. Mark, Freund, Yonathan, Galipienzo, Javier, Le Gal, Gregoire, Ghanima, Waleed, Kline, Jeffrey A., Huisman, Menno V., Moons, Karel G.M., Perrier, Arnaud, Parpia, Sameer, Robert-Ebadi, Helia, Righini, Marc, Roy, Pierre Marie, van Smeden, Maarten, Stals, Milou A.M., Wells, Philip S., de Wit, Kerstin, Kraaijpoel, Noémie, and van Es, Nick

Published
2022

50. Safety and Efficiency of Diagnostic Strategies for Ruling Out Pulmonary Embolism in Clinically Relevant Patient Subgroups: A Systematic Review and Individual-Patient Data Meta-analysis

Author

HAG Trombose, Epi Methoden, Cancer, JC onderzoeksprogramma Methodologie, Epi Methoden Team 3, Infection & Immunity, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Stals, Milou A.M., Takada, Toshihiko, Kraaijpoel, Noémie, van Es, Nick, Büller, Harry R., Courtney, D. Mark, Freund, Yonathan, Galipienzo, Javier, Le Gal, Grégoire, Ghanima, Waleed, Huisman, Menno V., Kline, Jeffrey A., Moons, Karel G.M., Parpia, Sameer, Perrier, Arnaud, Righini, Marc, Robert-Ebadi, Helia, Roy, Pierre Marie, van Smeden, Maarten, Wells, Phil S., de Wit, Kerstin, Geersing, Geert Jan, Klok, Frederikus A., HAG Trombose, Epi Methoden, Cancer, JC onderzoeksprogramma Methodologie, Epi Methoden Team 3, Infection & Immunity, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Stals, Milou A.M., Takada, Toshihiko, Kraaijpoel, Noémie, van Es, Nick, Büller, Harry R., Courtney, D. Mark, Freund, Yonathan, Galipienzo, Javier, Le Gal, Grégoire, Ghanima, Waleed, Huisman, Menno V., Kline, Jeffrey A., Moons, Karel G.M., Parpia, Sameer, Perrier, Arnaud, Righini, Marc, Robert-Ebadi, Helia, Roy, Pierre Marie, van Smeden, Maarten, Wells, Phil S., de Wit, Kerstin, Geersing, Geert Jan, and Klok, Frederikus A.

Published
2022

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