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144 results on '"Bønaa, Kaare Harald"'

6. Supplementary Table 1 from Circulating Folate, Vitamin B12, Homocysteine, Vitamin B12 Transport Proteins, and Risk of Prostate Cancer: a Case-Control Study, Systematic Review, and Meta-analysis

Author

Collin, Simon M., primary, Metcalfe, Chris, primary, Refsum, Helga, primary, Lewis, Sarah J., primary, Zuccolo, Luisa, primary, Smith, George Davey, primary, Chen, Lina, primary, Harris, Ross, primary, Davis, Michael, primary, Marsden, Gemma, primary, Johnston, Carole, primary, Lane, J. Athene, primary, Ebbing, Marta, primary, Bønaa, Kaare Harald, primary, Nygård, Ottar, primary, Ueland, Per Magne, primary, Grau, Maria V., primary, Baron, John A., primary, Donovan, Jenny L., primary, Neal, David E., primary, Hamdy, Freddie C., primary, Smith, A. David, primary, and Martin, Richard M., primary

Published
2023
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7. Data from Circulating Folate, Vitamin B12, Homocysteine, Vitamin B12 Transport Proteins, and Risk of Prostate Cancer: a Case-Control Study, Systematic Review, and Meta-analysis

Author

Collin, Simon M., primary, Metcalfe, Chris, primary, Refsum, Helga, primary, Lewis, Sarah J., primary, Zuccolo, Luisa, primary, Smith, George Davey, primary, Chen, Lina, primary, Harris, Ross, primary, Davis, Michael, primary, Marsden, Gemma, primary, Johnston, Carole, primary, Lane, J. Athene, primary, Ebbing, Marta, primary, Bønaa, Kaare Harald, primary, Nygård, Ottar, primary, Ueland, Per Magne, primary, Grau, Maria V., primary, Baron, John A., primary, Donovan, Jenny L., primary, Neal, David E., primary, Hamdy, Freddie C., primary, Smith, A. David, primary, and Martin, Richard M., primary

Published
2023
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8. Supplementary Table 2 from Circulating Folate, Vitamin B12, Homocysteine, Vitamin B12 Transport Proteins, and Risk of Prostate Cancer: a Case-Control Study, Systematic Review, and Meta-analysis

Author

Collin, Simon M., primary, Metcalfe, Chris, primary, Refsum, Helga, primary, Lewis, Sarah J., primary, Zuccolo, Luisa, primary, Smith, George Davey, primary, Chen, Lina, primary, Harris, Ross, primary, Davis, Michael, primary, Marsden, Gemma, primary, Johnston, Carole, primary, Lane, J. Athene, primary, Ebbing, Marta, primary, Bønaa, Kaare Harald, primary, Nygård, Ottar, primary, Ueland, Per Magne, primary, Grau, Maria V., primary, Baron, John A., primary, Donovan, Jenny L., primary, Neal, David E., primary, Hamdy, Freddie C., primary, Smith, A. David, primary, and Martin, Richard M., primary

Published
2023
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10. Cardiovascular outcomes after curative prostate cancer treatment: A population-based cohort study

Author

Kjellstadli, Camilla, Forster, Rachel Bedenis, Myklebust, Tor Åge, Bjørge, Tone, Bønaa, Kaare Harald, Helle, Svein Inge, and Kvåle, Rune

Subjects
Cancer Research, Oncology
Abstract

ObjectiveTo investigate differences in cardiovascular disease (CVD) morbidity and mortality after radical prostatectomy or definitive radiotherapy with or without androgen deprivation therapy (ADT).Materials and methodsWe used population-based data from the Cancer Registry of Norway, the Norwegian Patient Registry and the Norwegian Cause of Death Registry including 19 289 men ≤80 years diagnosed with non-metastatic prostate cancer during 2010-2019. Patients were treated with radical prostatectomy or definitive radiotherapy. We used competing risk models to compare morbidity from overall CVD, acute myocardial infarction (AMI), cerebral infarction, thromboembolism, and CVD-specific mortality for the overall cohort and stratified by prognostic risk groups.ResultsAfter a median follow-up time of 5.4 years (IQR 4.6 years), there were no differences in adjusted rates of AMI, cerebral infarction, and CVD-specific death between radical prostatectomy and definitive radiotherapy in any of the prognostic risk groups. Rates of overall CVD (0.82; 95% CI 0.76-0.89) and thromboembolism (0.30; 95% CI 0.20-0.44) were lower for definitive radiotherapy than radical prostatectomy during the first year of follow-up. After this overall CVD rates (1.19; 95% CI 1.11-1.28) were consistently higher across all risk groups in patients treated with definitive radiotherapy, but there were no differences regarding thromboembolism.ConclusionsDuring the first years after treatment, no differences were found in rates of AMI, cerebral infarction, and CVD-specific death between radiotherapy and radical prostatectomy in any of the prognostic risk groups. This suggests that ADT use in combination with radiotherapy may not increase the risks of these outcomes in a curative setting. The increased overall CVD rate for definitive radiotherapy after the first year indicates a possible relationship between definitive radiotherapy and other CVDs than AMI and cerebral infarction.

Published
2023

13. Treatment and 30-Day Mortality after Myocardial Infarction in Prostate Cancer Patients: A Population-Based Study from Norway.

Author

Forster, Rachel Bedenis, Kjellstadli, Camilla, Myklebust, Tor Åge, Egeland, Grace, Sulo, Gerhard, Bjørge, Tone, Bønaa, Kaare Harald, Juliusson, Petur Benedikt, and Kvåle, Rune

Subjects
PROSTATE cancer, CORONARY artery bypass, PROSTATE cancer patients, MYOCARDIAL infarction, PERCUTANEOUS coronary intervention, MYOCARDIAL perfusion imaging
Abstract

Introduction: There is limited knowledge about the use of invasive treatment and mortality after acute myocardial infarction (AMI) in prostate cancer (PCa) patients. We therefore wanted to compare rates of invasive treatment and 30-day mortality between AMIs in patients with PCa and AMIs in the general Norwegian male population. Methods: Norwegian population-based registry data from 2013 to 2019 were used in this cohort study to identify AMIs in patients with a preceding PCa diagnosis. We compared invasive treatment rates and 30-day mortality in AMI patients with PCa to the same outcomes in all male AMI patients in Norway. Invasive treatment was defined as performed angiography with or without percutaneous coronary intervention or coronary artery bypass graft surgery. Standardized mortality (SMR) and incidence ratios, and logistic regression were used to evaluate the association between PCa risk groups and invasive treatment. Results: In 1,018 patients with PCa of all risk groups, the total rates of invasive treatment for AMIs were similar to the rates in the general AMI population. In patients with ST-segment elevation AMIs, rates were lower in metastatic PCa compared to localized PCa (OR 0.15, 95% CI: 0.04–0.49). For non-ST-segment elevation AMIs, there were no differences between PCa risk groups. The 30-day mortality after AMI was lower in PCa patients than in the total population of similarly aged AMI patients (SMR 0.77, 95% CI: 0.61–0.97). Conclusion: Except for patients with metastatic PCa experiencing an ST-segment elevation AMI, PCa patients were treated as frequent with invasive treatment for their AMI as the general AMI population. 30-day all-cause mortality was lower after AMI in PCa patients compared to the general AMI population. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Drug-eluting versus bare metal stents in saphenous vein grafts compared to native coronary vessels. The NORSTENT study.

Author

Mølstad, Per Morten, primary, Nordrehaug, Jan Erik, additional, Steigen, Terje K., additional, Wilsgaard, Tom, additional, Wiseth, Rune, additional, Rotevatn, Svein, additional, Mannsverk, Jan, additional, Larsen, Tommy, additional, Larsby, Kristina Elisabet, additional, Skarstad, Sigrun Ådnegard, additional, Fosse, Eivind Øygard, additional, Dahl-Eriksen, Øystein, additional, and Bønaa, Kaare Harald, additional

Published
2021
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18. Incidence and risk factors for major bleeding among patients undergoing percutaneous coronary intervention: Findings from the Norwegian Coronary Stent Trial (NORSTENT)

Author

Samuelsen, Per-Jostein, primary, Eggen, Anne Elise, additional, Steigen, Terje, additional, Wilsgaard, Tom, additional, Kristensen, Andreas, additional, Skogsholm, Anne, additional, Holme, Elizabeth, additional, van den Heuvel, Christian, additional, Nordrehaug, Jan Erik, additional, Bendz, Bjørn, additional, Nilsen, Dennis W. T., additional, and Bønaa, Kaare Harald, additional

Published
2021
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21. Drug-Eluting versus Bare-Metal Stents in Saphenous Vein Grafts Compared to Native Coronary Vessels: The Norwegian Coronary Stent Trial Study.

Author

Mølstad, Per Morten, Nordrehaug, Jan Erik, Steigen, Terje K., Wilsgaard, Tom, Wiseth, Rune, Rotevatn, Svein, Mannsverk, Jan, Larsen, Tommy, Larsby, Kristina Elisabet, Skarstad, Sigrun Ådnegard, Fosse, Eivind Øygard, Dahl-Eriksen, Øystein, and Bønaa, Kaare Harald

Subjects
SAPHENOUS vein, CORONARY arteries, PERCUTANEOUS coronary intervention, MYOCARDIAL infarction
Abstract

Background: Drug-eluting stents (DES) reduce target lesion revascularization (TLR) with no effect on mortality or myocardial infarction (MI) compared to bare-metal stents (BMS) in native vessels. Randomized stent studies in saphenous vein grafts (SVG) are few and the reported effects are ambiguous. The Norwegian Coronary Stent Trial study is the first to randomize lesions to percutaneous coronary intervention in native vessels and SVG. Aims: The aim of this study was to compare the rate of mortality, MI, and TLR across stent and vessel types. Methods: In this substudy, 6,087 patients with a single lesion in native vessels and 164 in SVG were followed for 5 years. Results: MI was more frequent in SVG (subdistributional hazard ratio [SHR] 4.95 (3.75–6.54, p < 0.001), but not affected by stent type. In the first 500 days, DES reduced TLR in native vessels (SHR 0.21 (0.15–0.30) p < 0.001) and SVG (SHR 0.18 (0.04–0.80) p = 0.02). Thereafter, DES and BMS were equivalent in native vessels, but DES had a higher TLR rate than BMS in SVG (SHR 3.31 (1.23–8.94) p = 0.02). After 5 years, the TLR rate was still significantly lower for DES in native vessels (3.2% vs. 7.8%, p < 0.001) but not in SVG (21.4% vs. 18. 4%). Conclusion: In SVG, no difference in TLR between DES and BMS was observed after 5 years in contrast to persistent benefit in native vessels. The high rate of TLR and MI in SVG makes treatment of native vessels a preference whenever feasible and better treatment options for SVG are warranted. [ABSTRACT FROM AUTHOR]

Published
2022
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25. spub-ri-2017-0133-File004 – Supplemental material for Completeness and correctness of acute myocardial infarction diagnoses in a medical quality register and an administrative health register

Author

Govatsmark, Ragna Elise Støre, Janszky, Imre, Slørdahl, Stig Arild, Ebbing, Marta, Wiseth, Rune, Grenne, Bjørnar, Vesterbekkmo, Elisabeth, and Bønaa, Kaare Harald

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, spub-ri-2017-0133-File004 for Completeness and correctness of acute myocardial infarction diagnoses in a medical quality register and an administrative health register by Ragna Elise Støre Govatsmark, Imre Janszky, Stig Arild Slørdahl, Marta Ebbing, Rune Wiseth, Bjørnar Grenne, Elisabeth Vesterbekkmo and Kaare Harald Bønaa in Scandinavian Journal of Public Health

Published
2018
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31. Inter-rater reliability of a national acute stroke register

Author

Varmdal, Torunn, Ellekjær, Hanne, Fjærtoft, Hild, Indredavik, Bent, Lydersen, Stian, and Bønaa, Kaare Harald

Subjects
Medicine(all), Male, Observer Variation, Biochemistry, Genetics and Molecular Biology(all), Data quality, Reproducibility of Results, Stroke, VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurosurgery: 786, Humans, VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nevrokirurgi: 786, Female, Registries, Inter-rater reliability, Quality registers, Research Article, Aged
Abstract

Background Medical quality registers are useful sources of knowledge about diseases and the health services. However, there are challenges in obtaining valid and reliable data. This study aims to assess the reliability in a national medical quality register. Methods We randomly selected 111 patients having had a stroke in 2012. An experienced stroke nurse completed the Norwegian Stroke Register paper forms for all 111 patients by review of the medical records. We then extracted all registered data on the same patients from the Norwegian Stroke Register and calculated Cohen’s kappa and Gwet’s AC1 with 95 % confidence intervals for 51 nominal variables and Cohen’s quadratic weighted kappa and Gwet’s AC2 for three ordinal variables. For two time variables, we calculated the Intraclass Correlation Coefficient. Results Substantial to excellent reliability (kappa > 0.60/AC1 > 0.80) was observed for most variables related to past medical history, functional status, stroke subtype and discharge destination. Although excellent reliability was observed for time of stroke onset (ICC 0.93), this variable was hampered with a substantial amount of missing values. Some variables related to treatment and examinations in hospital displayed low levels of agreement. This applies to heart rate monitoring (kappa 0.17/AC1 0.46), swallowing test performed (kappa 0.19/AC1 0.27) and mobilized out of bed within 24 h after admission (kappa 0.04/AC1 −0.11). Conclusion A majority of the variables in The Norwegian Stroke Register have substantial to excellent reliability. The problem areas seem to be the lack of completeness in the time variable indicating stroke onset and poor reliability in some variables concerning examinations and treatment received in hospital. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Published
2015

33. Longitudinal and secular trends in total cholesterol levels and impact of lipid-lowering drug use among Norwegian women and men born in 1905–1977 in the population-based Tromsø Study 1979–2016

Author

Hopstock, Laila Arnesdatter, primary, Bønaa, Kaare Harald, additional, Eggen, Anne Elise, additional, Grimsgaard, Sameline, additional, Jacobsen, Bjarne K, additional, Løchen, Maja-Lisa, additional, Mathiesen, Ellisiv B, additional, Njølstad, Inger, additional, and Wilsgaard, Tom, additional

Published
2017
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44. Interrater reliability of a national acute myocardial infarction register.

Author

Støre Govatsmark, Ragna Elise, Sneeggen, Sylvi, Karlsaune, Hanne, Slørdahl, Stig Arild, and Bønaa, Kaare Harald

Subjects
INTER-observer reliability, MYOCARDIAL infarction diagnosis, MYOCARDIAL infarction treatment, MEDICAL registries, DATA quality
Abstract

Background: Disease-specific registers may be used for measuring and improving healthcare and patient outcomes, and for disease surveillance and research, provided they contain valid and reliable data. The aim of this study was to assess the interrater reliability of all variables in a national myocardial infarction register. Methods: We randomly selected 280 patients who had been enrolled from 14 hospitals to the Norwegian Myocardial Infarction Register during the year 2013. Experienced audit nurses, who were blinded to the data about the 280 patients already in the register, completed the Norwegian Myocardial Infarction paper forms for 240 patients by review of medical records. We then extracted all registered data on the same patients from the Norwegian Myocardial Infarction Register. To compare the interrater reliability between the register and the audit nurses, we calculated intraclass correlations coefficient for continuous variables, Cohen's kappa and Gwet's first agreement coefficient (AC1) for nominal variables, and quadratic weighted Cohen's kappa and Gwet's second AC for ordinal variables. Results: We found excellent (AC1 >0.80) or good (AC1 0.61-0.80) agreement for most variables, including date and time variables, medical history, investigations and treatments during hospitalization, medication at discharge, and ST-segment elevation or non-ST-segment elevation acute myocardial infarction. However, only moderate agreement (AC1 0.41-0.60) was found for family history of coronary heart disease, diagnostic electrocardiography, and complications during hospitalization, whereas fair agreement (AC1 0.21-0.40) was found for acute myocardial infarction location. A high percentage of missing data was found for symptom onset, family history, body mass index, infarction location, and new Q-wave. Conclusion: Most variables in Norwegian Myocardial Infarction Register had excellent or good reliability. However, some important variables had lower reliability than expected or had missing data. Precise definitions of data elements and proper training of data abstractors are necessary to ensure that clinical registries contain valid and reliable data. [ABSTRACT FROM AUTHOR]

Published
2016
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49. Circulating Folate, Vitamin B12, Homocysteine, Vitamin B12 Transport Proteins, and Risk of Prostate Cancer: a Case-Control Study, Systematic Review, and Meta-analysis

Author

Collin, Simon M., primary, Metcalfe, Chris, additional, Refsum, Helga, additional, Lewis, Sarah J., additional, Zuccolo, Luisa, additional, Smith, George Davey, additional, Chen, Lina, additional, Harris, Ross, additional, Davis, Michael, additional, Marsden, Gemma, additional, Johnston, Carole, additional, Lane, J. Athene, additional, Ebbing, Marta, additional, Bønaa, Kaare Harald, additional, Nygård, Ottar, additional, Ueland, Per Magne, additional, Grau, Maria V., additional, Baron, John A., additional, Donovan, Jenny L., additional, Neal, David E., additional, Hamdy, Freddie C., additional, Smith, A. David, additional, and Martin, Richard M., additional

Published
2010
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