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Distinctive management is one of the branches of modern human science, a science whose focus is on finding the best way to accomplish the tasks assigned to the workforce to achieve the desired objectives of the institutions to the fullest, and the administration can be defined in general as a set of rules and principles used by the manager In order to harness the resources and use them in the most appropriate manner to achieve the desired objectives of the establishment with the least time, effort and cost possible, and this research focused on a new management tool called Balanced Scorecard, which runs in line with the strategic plan of the Foundation, The management itself often deceives itself by saying that the bottom line is everything, and the truth is that managers can not ignore this line, because the performance indicator refers to what happened, and this is not what is required. The Balanced Scorecard not only measures how you do it, How it works, and what you can expect to do in the future. By doing so, the management of the sporting institution will be able to work according to a clear vision and thus improve performance. Taking into account that the Balanced Scorecard takes the principle that all organizations are based on their employees. The four axes in the card focus on balancing the efforts of the employees to record the measurements that were defined in order to evaluate the objectives from each axis perspective according to a clear and comfortable scoring score. So that everyone in the organization can know the progress made by the institution in achieving its objectives. In addition, the concept of the balanced performance card has been addressed and its usefulness and mechanism of application, {"references":["1-\tأحمد ماهر: السلوك التنظيمي- مدخل بناء المهارات، الدار الجامعية، ط07، القاهرة، مصر، 2000.","2-\tرحيم حسين: التغيير في المؤسسة ودور الكفاءات- مدخل النظم، مجلة العلوم الإنسانية، العدد07، فيفري2005، جامعة محمد خيضر، بسكرة.","3-\tعناتي، رضوان محمد: بناء نموذج قياس وتقويم أداء شركات المقاولات الأردنية باستخدام بطاقة العلامات المتوازنة، أطروحة دكتوراه، جامعة عمان العربية للدراسات العليا، 2004.","4-\tعبد اللطيف وحنان تركمان: بطاقة التصويب المتوازنة، مجلة جامعة تشرين للدراسات والبحوث العلمية، سلسلة العلوم الاقتصادية والقانونية، المجلد 28، العدد 1. 2004.","5-\tفتح الله غانم: بطاقة التصويب المتوازنة وإستراتيجية أسفل إلى أعلى، جامعة القدس، 2011","6-\tمات سيقر: المرجع العالمي لإدارة الجودة، دار الفاروق ، القاهرة، 2008.","7-\tنصير قاسم خلف : نموذج مقترح لإدارة العلاقات العامة في المؤسسات الرياضية في العراق، جامعة العراق ، 2011.","8-\tخالد رجم . خولة واصل . الويزة سعادة: واقع الاقتصاد الرقمي في الجزائر ''دراسة تحليلية لقطاع تكنولوجيا المعلومات والاتصال'' مجلة النمو الاقتصادي والمقاولاتية ، المجلد 1, العدد 2018","9-\tهجيرة بولومة . أحمد رضا ميموني . مختارية خراف .: تحليل واقع الاقتصاد المعرفي في الجزائر مجلة النمو الاقتصادي والمقاولاتية ، المجلد 3, العدد2 2020","10-\tKaplan, R., & Norton, D. (1996). Translating Strategy into Action: The Balance Scorecard. Boston: Harvard University Press","11-\t Mary . A .Malina & Frank H. Selto . Communicating and Controlling Strategy An Empirical study of Effectiveness of the Balanced Scorecards .Journal of management Accounting , 2001","12-\tMohammed Tikrity, Using AHP Method to Align and Integrate HR Metrics to Organisations' Balanced Scorecard, Jordan.june 2012","Oussama Attahir , La gestion du Plan Directeur de Production (PDP) et du Plan d'Assemblage Final (PAF). مجلة النمو الاقتصادي والمقاولاتية المجلد 1, العدد 22018"]}

Ovarian cysts (OC) are one of the major factors affecting the fertility of dairy cattle due to their negative effects on reproductive performances, causing great economic losses. They have been traditionally defined as anovulatory follicular structures with a diameter exceeding 20 or 25 mm, lasting at least 10 days on the ovary in the absence of a functional corpus luteum. However, in recent years, the development of ovarian ultrasound and hormonal assays, particularly progesterone (P4), have provided additional information, thus changing the definition of this disease. These methods were proposed as the most effective combination for the diagnosis of OC. Treatments are primarily based on the use of different hormones or hormonal associations. Particularly, the standard treatment is GnRH. PGF2α is very effective in the case of luteal cyst. However, treatment failures observed with commonly administered hormones require the use of second-line treatments. Therefore, the Ovsynch protocol and progestogen appear to be a possible alternative in OC treatment. In order to prevent OC formation and to reduce OC incidence, strategies should focus on reducing diseases and stress and optimizing food intake during dry-off and post-partum (PP) periods. Medical prevention has been proposed with the same substances commonly used in treatment (GnRH, PGF2α)., Ciste jajnika (OC) jedan su od glavnih čimbenika koji utječe na plodnost mliječne stoke uslijed njihovih negativnih učinka na reproduktivne pokozatelje, prouzročeći velike ekonomske gubike. Tradicionalno se definiraju kao anovulatorne folikularne strukture promjera većeg od 20-25 mm koje perzistiraju najmanje 10 dana na jajniku u izostanku funkcionalnog žutog tijela. Međutim, posljednjih godina, uporaba ultrazvuka u dijagnostici stanja jajnika, kao i hormonskih testova, posebice progesteronskih (P4), osigurao je dodatne informacije, mijenjajujući time definiciju ove bolesti. Ove metode predložene su kao najučinkovitija dijagnostička kombinacija za dijagnozu OCa. Glavne terapije baziraju se na uporabi različitih hormona ili njihovoj kombinaciji. Standardno liječenje posebice predstavlja uporaba GnRH. U slučaju luteinskih cista PGF2α je vrlo učinkovit. Međutim, neuspjesi liječenja zamijećeni s uobičajeno primijenjenim hormonima zahtijevaju drugu i drugačiju metodu liječenja. Stoga se Ovsynch protokol i gestageni čine kao moguća alternativa u liječenju OC-a. Kako bi se spriječilo formiranje OC-a i smanjila incidencija OC-a, strategije je potrebno usredotočiti na smanjenje bolesti i stresa i optimizaciju unosa hrane tijekom suhostaja i razdoblja nakon teljenja (PP). Predložena je medicinska prevencija s istim molekulama koje se uobičajeno rabe u liječenju(GnRH, PGF2α).

Background Gastric and colorectal cancers are the most common malignant tumours, leading to a significant number of cancer-related deaths worldwide. Recently, increasing evidence has demonstrated that cancer cells exhibit a differential expression of potassium channels and this can contribute to cancer progression. However, their expression and localisation at the somatic level remains uncertain. In this study, we have investigated the expression levels of KCNB1 and KCNA5 genes encoding ubiquitous Kv2.1 and Kv1.5 potassium channels in gastric and colorectal tumours. Methods Gastric and colorectal tumoral and peritumoral tissues were collected to evaluate the expression of KCNB1 and KCNA5 mRNA by quantitative PCR. Moreover, the immunohistochemical staining profile of Kv2.1 and Kv1.5 was assessed on 40 Formalin-Fixed and Paraffin-Embedded (FFPE) gastric carcinoma tissues. Differences in gene expression between tumoral and peritumoral tissues were compared statistically with the Mann-Whitney U test. The association between the clinicopathological features of the GC patients and the expression of both Kv proteins was investigated with χ2 and Fisher’s exact tests. Results The mRNA fold expression of KCNB1 and KCNA5 genes showed a lower mean in the tumoral tissues (0.06 ± 0.17, 0.006 ± 0.009) compared to peritumoral tissues (0.08 ± 0.16, 0.16 ± 0.48, respectively) without reaching the significance rate (p = 0.861, p = 0.152, respectively). Interestingly, Kv2.1 and Kv1.5 immunostaining was detectable and characterised by a large distribution in peritumoral and tumoral epithelial cells. More interestingly, inflammatory cells were also stained. Surprisingly, Kv2.1 and Kv1.5 staining was undoubtedly and predominantly detected in the cytoplasm compartment of tumour cells. Indeed, the expression of Kv2.1 in tumour cells revealed a significant association with the early gastric cancer clinical stage (p = 0.026). Conclusion The data highlight, for the first time, the potential role of Kv1.5 and Kv2.1 in gastrointestinal-related cancers and suggests they may be promising prognostic markers for these tumours.

International audience; Hepatocellular carcinoma (HCC) is a major public health issue in Africa. In Tunisia, hepatitis B virus (HBV) is known to be an important risk factor for HCC in the south of the country, but the role played by hepatitis C virus (HCV) still remains unclear. The aim of the current case-control study was to identify risk factors for HCC development in the northern part of the country. Clinical and biological data including viral hepatitis status (serological and molecular) and non-infectious risk factors from 73 patients with HCC and 70 control subjects without hepatic diseases were collected. The mean age of the patients was 63 ± 10 years, and the ratio of males to females was 1.1. HCC occurred in cirrhotic liver in 72.0% of the cases. HCV infection was the dominant risk factor (64.3% of cases); the presence of HBV was observed in 53.4% of the cases. Occult hepatitis B and C were implicated, respectively, in 30.1% and 9.6% of the cases. HCV genotype 1b was predominant. Patients originating from western Tunisia formed a homogeneous group, characterized by significantly higher rates of tattoos or scarifications (83%) and HCV infection (80%) than those from other parts of the country. Chronic HCV infection is currently the primary risk factor for HCC in Tunisia; HBV infection remains frequent in its overt or occult infection forms. Traditional esthetic practices apparently contribute to increasing the burden of terminal liver diseases in western Tunisia.