Search

Your search keyword '"Azzi-Martin, Lamia"' showing total 24 results
Start Over Author "Azzi-Martin, Lamia"
24 results on '"Azzi-Martin, Lamia"'

1. CD44v3 is a marker of invasive cancer stem cells driving metastasis in gastric carcinoma

Author

Giraud, Julie, Seeneevassen, Lornella, Rousseau, Benoit, Bouriez, Damien, Sifré, Elodie, Giese, Alban, Nguyen, Tra Ly, Tiffon, Camille, Lippi, Yannick, Azzi-Martin, Lamia, Pannequin, Julie, Ménard, Armelle, Bessède, Emilie, Staedel, Cathy, Mégraud, Francis, Belleannée, Geneviève, Lehours, Philippe, Gronnier, Caroline, Dubus, Pierre, and Varon, Christine

Published
2023
Full Text
View/download PDF

9. Spotlight on hTERT Complex Regulation in Cutaneous T-Cell Lymphomas

Author

Ropio, Joana, primary, Prochazkova-Carlotti, Martina, additional, Batista, Rui, additional, Pestana, Ana, additional, Chebly, Alain, additional, Ferrer, Jacky, additional, Idrissi, Yamina, additional, Cappellen, David, additional, Durães, Cecília, additional, Boaventura, Paula, additional, Vinagre, João, additional, Azzi-Martin, Lamia, additional, Poglio, Sandrine, additional, Cabeçadas, José, additional, Campos, Manuel António, additional, Beylot-Barry, Marie, additional, Sobrinho-Simões, Manuel, additional, Merlio, Jean-Philippe, additional, Soares, Paula, additional, and Chevret, Edith, additional

Published
2023
Full Text
View/download PDF

10. CD44v3 is a marker of invasive cancer stem cells driving metastasis in gastric carcinoma

Author

Giraud, Julie, primary, Seeneevassen, Lornella, additional, Rousseau, Benoit, additional, Bouriez, Damien, additional, Sifré, Elodie, additional, Giese, Alban, additional, Nguyen, Tra Ly, additional, Tiffon, Camille, additional, Lippi, Yannick, additional, Azzi-Martin, Lamia, additional, Pannequin, Julie, additional, Ménard, Armelle, additional, Bessède, Emilie, additional, Staedel, Cathy, additional, Mégraud, Francis, additional, Belleannée, Geneviève, additional, Lehours, Philippe, additional, Gronnier, Caroline, additional, Dubus, Pierre, additional, and Varon, Christine, additional

Published
2022
Full Text
View/download PDF

12. Autophagy induced by Helicobacter pylori infection is necessary for gastric cancer stem cell emergence

Author

Ligue Nationale contre le Cancer (France), Courtois, Sarah, Haykal, Maria, Bodineau, Clément, Sifré, Elodie, Azzi-Martin, Lamia, Ménard, Armelle, Mégraud, Francis, Lehours, Philippe, Durán, Raúl V., Varon, Christine, Bessède, Emilie, Ligue Nationale contre le Cancer (France), Courtois, Sarah, Haykal, Maria, Bodineau, Clément, Sifré, Elodie, Azzi-Martin, Lamia, Ménard, Armelle, Mégraud, Francis, Lehours, Philippe, Durán, Raúl V., Varon, Christine, and Bessède, Emilie

Abstract

Background: The main cause of gastric cancer is the infection by the bacterium Helicobacter pylori which induces a chronic inflammation and an epithelial-to-mesenchymal transition (EMT) leading to the emergence of cells with cancer stem cell (CSC) properties. However, the underlying mechanisms have not been fully characterized. Moreover, H. pylori modulates the host cell autophagic process, but a few studies have investigated the role of this process in tumoral transformation. The aim of this study was to determine whether H. pylori-induced autophagy has a role in CSC emergence. Methods: Autophagic flux in response to H. pylori infection was characterized in AGS cell line expressing the tandem-tagged mCherry-GFP-LC3 protein and using a ratiometric flow cytometry analysis. Then, AGS and MKN45 cell lines were treated with bafilomycin or chloroquine, two pharmaceutical well-known inhibitors of autophagy, and different EMT and CSC characteristics were analyzed. Results: First, a co-expression of the gastric CSC marker CD44 and the autophagic marker LC3 in mice and human stomach tissues infected with H. pylori was observed. Then, we demonstrated in vitro that H. pylori was able to activate the autophagy process with a reduced autophagic flux. Finally, infected cells were treated with autophagy inhibitors, which reduced (i) appearance of mesenchymal phenotypes and migration ability related to EMT and (ii) CD44 expression as well as tumorsphere formation capacities reflecting CSC properties. Conclusion: In conclusion, all these data show that H. pylori-induced autophagy is implicated in gastric CSC emergence and could represent an interesting therapeutic target.

Published
2021

17. Reliable blood cancer cells' telomere length evaluation by qPCR

Author

Ropio, Joana, primary, Chebly, Alain, additional, Ferrer, Jacky, additional, Prochazkova‐Carlotti, Martina, additional, Idrissi, Yamina, additional, Azzi‐Martin, Lamia, additional, Cappellen, David, additional, Pham‐Ledard, Anne, additional, Soares, Paula, additional, Merlio, Jean‐Philippe, additional, and Chevret, Edith, additional

Published
2020
Full Text
View/download PDF

18. Helicobacter pylori infection induces mTORC1 inhibition in human gastric cancer cells

Author

Courtois, Sarah, Bodineau, Clément, Haykal, Maria, Sifré, Elodie, Azzi-Martin, Lamia, Mégraud, Francis, Lehours, Philippe, Varon, Christine, Durán, Raúl V., and Bessède, Emilie

Abstract

Trabajo presentado en la 27th UEG Week (United European Gastroenterology), celebrada en Barcelona (España), del 19 al 23 de octubre de 2019

Published
2019

19. Alzheimer’s Disease and Helicobacter pylori Infection: Inflammation from Stomach to Brain?

Author

Albaret, Guillaume, primary, Sifré, Elodie, additional, Floch, Pauline, additional, Laye, Sophie, additional, Aubert, Agnès, additional, Dubus, Pierre, additional, Azzi-Martin, Lamia, additional, Giese, Alban, additional, Salles, Nathalie, additional, Mégraud, Francis, additional, Varon, Christine, additional, Lehours, Philippe, additional, and Roubaud-Baudron, Claire, additional

Published
2020
Full Text
View/download PDF

20. Cytolethal distending toxin induces the formation of transient messenger-rich ribonucleoprotein nuclear invaginations in surviving cells

Author

Azzi-Martin, Lamia, primary, He, Wencan, additional, Péré-Védrenne, Christelle, additional, Korolik, Victoria, additional, Alix, Chloé, additional, Prochazkova-Carlotti, Martina, additional, Morel, Jean-Luc, additional, Le Roux-Goglin, Emilie, additional, Lehours, Philippe, additional, Djavaheri-Mergny, Mojgan, additional, Grosset, Christophe F., additional, Varon, Christine, additional, Dubus, Pierre, additional, and Ménard, Armelle, additional

Published
2019
Full Text
View/download PDF

23. Discoloration Study of Azo Dye Solution Using the Fenton Process

Author

Wakrim, Asmaa, Byoud, Fouzia, El Ghachtouli, Sanae, Jamal Eddine, Jamal, Azzi-Martin, Lamia, Azzi, Mohammed, Wakrim, Asmaa, Byoud, Fouzia, El Ghachtouli, Sanae, Jamal Eddine, Jamal, Azzi-Martin, Lamia, and Azzi, Mohammed

Abstract

The discoloration of Carmoisine at an initial concentration of 1 g/L, by the Fenton process (Fe2+/ H2O2) has been studied. The efficiency of this process in the discoloration of Carmoisine, as well as the influence of the reaction parameters, was discussed. The effects of initial pH, Fe2+ and H2O2 concentrations, and treatment duration on the discoloration kinetic were evaluated. Our results showed that the best discoloration efficiency has reached 94 % and was achieved in 20 minutes of treatment with 3.57 mmol/L Fe2+, 194.1 mmol/L H2O2, at pH = 3. The discoloration kinetics of the carmoisine followed the BMG model.

Published
2018

24. First isolation of Campylobacter vicugnae sp. nov. in humans suffering from gastroenteritis.

Author

Jehanne Q, Bénéjat L, Azzi Martin L, Korolik V, Ducournau A, Aptel J, Ménard A, Jauvain M, Aguilera C, Doreille A, Mesnard L, Eckert C, and Lehours P

Subjects
Humans, Female, Male, Caco-2 Cells, Bacterial Toxins genetics, DNA, Bacterial genetics, Foodborne Diseases microbiology, Campylobacter genetics, Campylobacter isolation & purification, Campylobacter classification, Gastroenteritis microbiology, Campylobacter Infections microbiology, Campylobacter Infections veterinary, Phylogeny, RNA, Ribosomal, 16S genetics
Abstract

The present study describes the first isolation of a recently described Campylobacter species, Campylobacter vicugnae , in humans. The isolates were recovered by two independent French laboratories in 2020 and 2022 from a man and a woman suffering from gastroenteritis. Biochemical and growth characteristics, and electron microscopy for these two strains indicated that they belong to Campylobacter genus. 16S rDNA and GyrA-based phylogeny, as well as average nucleotide identity and in silico DNA-DNA Hybridization analyses revealed that both strains belong to the Campylobacter vicugnae species. Both isolates possess a complete cytolethal distending toxin (CDT) locus with cdtA , cdtB, and cdt C, and features of CDT activity were demonstrated in vitro with Caco-2 intestinal epithelial cells. Our data suggest that these two isolates of C. vicugnae were associated with gastroenteritis in humans and induced major cytopathogenic effects in vitro . C. vicugnae is likely to be a novel human pathogen, with a source of foodborne infection that needs to be determined.IMPORTANCE Campylobacter species that display toxicity features are a worldwide public health issue. In clinical contexts, it is crucial to identify which isolate could be an urgent threat to a patient. Actual and widely used laboratory methods such as mass spectrometry or PCR may be flawed in the field of species identification. In contrast, the present study shows that next-generation sequencing allows to precisely identify isolates to species level that may have been omitted otherwise. Moreover, it helps to identify emerging species before they become a threat to human health. Recovery of a new Campylobacter species in human sample, such as the new species " Campylobacter vicugnae ," is an important step for the identification of emerging pathogens posing threat to global health., Competing Interests: The authors declare no conflict of interest.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results