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2,214 results on '"Azzarello A"'

1. Hadronic cross section measurements with the DAMPE space mission using 20GeV-10TeV cosmic-ray protons and $^4$He

Author

Alemanno, F., An, Q., Azzarello, P., Barbato, F. C. T., Bernardini, P., Bi, X. J., Cagnoli, I., Cai, M. S., Casilli, E., Catanzani, E., Chang, J., Chen, D. Y., Chen, J. L., Chen, Z. F., Coppin, P., Cui, M. Y., Cui, T. S., Cui, Y. X., Dai, H. T., De Benedittis, A., De Mitri, I., de Palma, F., Di Giovanni, A., Ding, Q., Dong, T. K., Dong, Z. X., Donvito, G., Droz, D., Duan, J. L., Duan, K. K., Fan, R. R., Fan, Y. Z., Fang, F., Fang, K., Feng, C. Q., Feng, L., Frieden, J. M., Fusco, P., Gao, M., Gargano, F., Gong, K., Gong, Y. Z., Guo, D. Y., Guo, J. H., Han, S. X., Hu, Y. M., Huang, G. S., Huang, X. Y., Huang, Y. Y., Ionica, M., Jiang, L. Y., Jiang, Y. Z., Jiang, W., Kong, J., Kotenko, A., Kyratzis, D., Lei, S. J., Li, W. H., Li, W. L., Li, X., Li, X. Q., Liang, Y. M., Liu, C. M., Liu, H., Liu, J., Liu, S. B., Liu, Y., Loparco, F., Luo, C. N., Ma, M., Ma, P. X., Ma, T., Ma, X. Y., Marsella, G., Mazziotta, M. N., Mo, D., Niu, X. Y., Pan, X., Parenti, A., Peng, W. X., Peng, X. Y., Perrina, C., Putti-Garcia, E., Qiao, R., Rao, J. N., Ruina, A., Sarkar, R., Savina, P., Serpolla, A., Shangguan, Z., Shen, W. H., Shen, Z. Q., Shen, Z. T., Silveri, L., Song, J. X., Stolpovskiy, M., Su, H., Su, M., Sun, H. R., Sun, Z. Y., Surdo, A., Teng, X. J., Tykhonov, A., Wang, J. Z., Wang, L. G., Wang, S., Wang, S. X., Wang, X. L., Wang, Y., Wang, Y. F., Wang, Y. Z., Wang, Z. M., Wei, D. M., Wei, J. J., Wei, Y. F., Wu, D., Wu, J., Wu, S. S., Wu, X., Xia, Z. Q., Xu, H. T., Xu, J., Xu, Z. H., Xu, Z. L., Xu, E. H., Xu, Z. Z., Xue, G. F., Yang, H. B., Yang, P., Yang, Y. Q., Yao, H. J., Yu, Y. H., Yuan, G. W., Yuan, Q., Yue, C., Zang, J. J., Zhang, S. X., Zhang, W. Z., Zhang, Yan, Zhang, Yi, Zhang, Y. J., Zhang, Y. L., Zhang, Y. P., Zhang, Y. Q., Zhang, Z., Zhang, Z. Y., Zhao, C., Zhao, H. Y., Zhao, X. F., Zhou, C. Y., and Zhu, Y.

Subjects
High Energy Physics - Experiment
Abstract

Precise direct cosmic-ray (CR) measurements provide an important probe to study the energetic particle sources in our Galaxy, and the interstellar environment through which these particles propagate. Uncertainties on hadronic models, ion-nucleon cross sections in particular, are currently the limiting factor towards obtaining more accurate CR ion flux measurements with calorimetric space-based experiments. We present an energy-dependent measurement of the inelastic cross section of protons and helium-4 nuclei (alpha particles) on a Bi$_4$Ge$_3$O$_{12}$ target, using 88 months of data collected by the DAMPE space mission. The kinetic energy range per nucleon of the measurement points ranges from 18 GeV to 9 TeV for protons, and from 5 GeV/n to 3 TeV/n for helium-4 nuclei. Our results lead to a significant improvement of the CR flux normalisation. In the case of helium-4, these results correspond to the first cross section measurements on a heavy target material at energies above 10 GeV/n., Comment: 17 pages, submitted to PRD

Published
2024

2. Cephalopod-inspired jetting devices for gastrointestinal drug delivery

Author

Arrick, G., Sticker, D., Ghazal, A., Lu, Y., Duncombe, T., Gwynne, D., Mouridsen, B., Wainer, J., Jepsen, J. P. H., Last, T. S., Schultz, D., Hess, K., Medina De Alba, E., Min, S., Poulsen, M., Anker, C., Karandikar, P., Pedersen, H. D., Collins, J., Egecioglu, N. E., Tamang, S., Cleveland, C., Ishida, K., Uhrenfeldt, A. H., Kuosmanen, J., Pereverzina, M., Hayward, A., Kirk, R. K., You, S., Dalsgaard, C. M., Gunnarsson, S. B., Patsi, I., Bohr, A., Azzarello, A., Frederiksen, M. R., Herskind, P., Li, J., Roxhed, N., Rahbek, U. L., Water, J. J., Buckley, S. T., and Traverso, G.

Published
2024
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6. Implementing interdisciplinary sustainability education with the food-energy-water (FEW) nexus

Author

Romulo, Chelsie, Venkataraman, Bhawani, Caplow, Susan, Ajgaonkar, Shamili, Allen, Craig R., Anandhi, Aavudai, Anderson, Steven W., Azzarello, Caterina Belle, Brundiers, Katja, Blavascunas, Eunice, Dauer, Jenny M., Druckenbrod, Daniel L., Fairchild, Ennea, Horne, Lydia R., Lee, Kyungsun, Mwale, Marizvkuru, Mischler, John, Pappo, Emily, Patel, Nirav S., Sintov, Nicole D., Ramsdell, Carla S., and Vincent, Shirley G.

Published
2024
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8. FEW questions, many answers: using machine learning to assess how students connect food–energy–water (FEW) concepts

Author

Emily A. Royse, Amanda D. Manzanares, Heqiao Wang, Kevin C. Haudek, Caterina Belle Azzarello, Lydia R. Horne, Daniel L. Druckenbrod, Megan Shiroda, Sol R. Adams, Ennea Fairchild, Shirley Vincent, Steven W. Anderson, and Chelsie Romulo

Subjects
History of scholarship and learning. The humanities, AZ20-999, Social Sciences
Abstract

Abstract There is growing support and interest in postsecondary interdisciplinary environmental education, which integrates concepts and disciplines in addition to providing varied perspectives. There is a need to assess student learning in these programs as well as rigorous evaluation of educational practices, especially of complex synthesis concepts. This work tests a text classification machine learning model as a tool to assess student systems thinking capabilities using two questions anchored by the Food-Energy-Water (FEW) Nexus phenomena by answering two questions (1) Can machine learning models be used to identify instructor-determined important concepts in student responses? (2) What do college students know about the interconnections between food, energy, and water, and how have students assimilated systems thinking into their constructed responses about FEW? Reported here is a broad range of model performances across 26 text classification models associated with two different assessment items, with model accuracy ranging from 0.755 to 0.992. Expert-like responses were infrequent in our dataset compared to responses providing simpler, incomplete explanations of the systems presented in the question. For those students moving from describing individual effects to multiple effects, their reasoning about the mechanism behind the system indicates advanced systems thinking ability. Specifically, students exhibit higher expertise in explaining changing water usage than discussing trade-offs for such changing usage. This research represents one of the first attempts to assess the links between foundational, discipline-specific concepts and systems thinking ability. These text classification approaches to scoring student FEW Nexus Constructed Responses (CR) indicate how these approaches can be used, in addition to several future research priorities for interdisciplinary, practice-based education research. Development of further complex question items using machine learning would allow evaluation of the relationship between foundational concept understanding and integration of those concepts as well as a more nuanced understanding of student comprehension of complex interdisciplinary concepts.

Published
2024
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9. Implementing interdisciplinary sustainability education with the food-energy-water (FEW) nexus

Author

Chelsie Romulo, Bhawani Venkataraman, Susan Caplow, Shamili Ajgaonkar, Craig R. Allen, Aavudai Anandhi, Steven W. Anderson, Caterina Belle Azzarello, Katja Brundiers, Eunice Blavascunas, Jenny M. Dauer, Daniel L. Druckenbrod, Ennea Fairchild, Lydia R. Horne, Kyungsun Lee, Marizvkuru Mwale, John Mischler, Emily Pappo, Nirav S. Patel, Nicole D. Sintov, Carla S. Ramsdell, and Shirley G. Vincent

Subjects
History of scholarship and learning. The humanities, AZ20-999, Social Sciences
Abstract

Abstract Growth in the green jobs sector has increased demand for college graduates who are prepared to enter the workforce with interdisciplinary sustainability skills. Simultaneously, scholarly calls for interdisciplinary collaboration in the service of addressing the societal challenges of enhancing resilience and sustainability have also increased in recent years. However, developing, executing, and assessing interdisciplinary content and skills at the post-secondary level has been challenging. The objective of this paper is to offer the Food-Energy-Water (FEW) Nexus as a powerful way to achieve sustainability competencies and matriculate graduates who will be equipped to facilitate the transformation of the global society by meeting the targets set by the United Nations Sustainable Development Goals. The paper presents 10 curricular design examples that span multiple levels, including modules, courses, and programs. These modules enable clear evaluation and assessment of key sustainability competencies, helping to prepare graduates with well-defined skillsets who are equipped to address current and future workforce needs.

Published
2024
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11. Measurement of the cosmic p+He energy spectrum from 50 GeV to 0.5 PeV with the DAMPE space mission

Author

DAMPE Collaboration, Alemanno, F., Altomare, C., An, Q., Azzarello, P., Barbato, F. C. T., Bernardini, P., Bi, X. J., Cagnoli, I., Cai, M. S., Casilli, E., Catanzani, E., Chang, J., Chen, D. Y., Chen, J. L., Chen, Z. F., Coppin, P., Cui, M. Y., Cui, T. S., Cui, Y. X., Dai, H. T., De Benedittis, A., De Mitri, I., de Palma, F., Deliyergiyev, M., Di Giovanni, A., Di Santo, M., Ding, Q., Dong, T. K., Dong, Z. X., Donvito, G., Droz, D., Duan, J. L., Duan, K. K., Fan, R. R., Fan, Y. Z., Fang, F., Fang, K., Feng, C. Q., Feng, L., Alonso, M. Fernandez, Frieden, J. M., Fusco, P., Gao, M., Gargano, F., Gong, K., Gong, Y. Z., Guo, D. Y., Guo, J. H., Han, S. X., Hu, Y. M., Huang, G. S., Huang, X. Y., Huang, Y. Y., Ionica, M., Jiang, L. Y., Jiang, Y. Z., Jiang, W., Kong, J., Kotenko, A., Kyratzis, D., Lei, S. J., Li, W. H., Li, W. L., Li, X., Li, X. Q., Liang, Y. M., Liu, C. M., Liu, H., Liu, J., Liu, S. B., Liu, Y., Loparco, F., Luo, C. N., Ma, M., Ma, P. X., Ma, T., Ma, X. Y., Marsella, G., Mazziotta, M. N., Mo, D., Salinas, M. Muñoz, Niu, X. Y., Pan, X., Parenti, A., Peng, W. X., Peng, X. Y., Perrina, C., Putti-Garcia, E., Qiao, R., Rao, J. N., Ruina, A., Shangguan, Z., Shen, W. H., Shen, Z. Q., Shen, Z. T., Silveri, L., Song, J. X., Stolpovskiy, M., Su, H., Su, M., Sun, H. R., Sun, Z. Y., Surdo, A., Teng, X. J., Tykhonov, A., Wang, J. Z., Wang, L. G., Wang, S., Wang, S. X., Wang, X. L., Wang, Y., Wang, Y. F., Wang, Y. Z., Wang, Z. M., Wei, D. M., Wei, J. J., Wei, Y. F., Wu, D., Wu, J., Wu, L. B., Wu, S. S., Wu, X., Xia, Z. Q., Xu, H. T., Xu, J., Xu, Z. H., Xu, Z. L., Xu, E. H., Xu, Z. Z., Xue, G. F., Yang, H. B., Yang, P., Yang, Y. Q., Yao, H. J., Yu, Y. H., Yuan, G. W., Yuan, Q., Yue, C., Zang, J. J., Zhang, S. X., Zhang, W. Z., Zhang, Yan, Zhang, Yi, Zhang, Y. J., Zhang, Y. L., Zhang, Y. P., Zhang, Y. Q., Zhang, Z., Zhang, Z. Y., Zhao, C., Zhao, H. Y., Zhao, X. F., Zhou, C. Y., and Zhu, Y.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract

Recent observations of the light component of the cosmic-ray spectrum have revealed unexpected features that motivate further and more precise measurements up to the highest energies. The Dark Matter Particle Explorer is a satellite-based cosmic-ray experiment that has been operational since December 2015, continuously collecting data on high-energy cosmic particles with very good statistics, energy resolution, and particle identification capabilities. In this work, the latest measurements of the energy spectrum of proton+helium in the energy range from 46 GeV to 464 TeV are presented. Among the most distinctive features of the spectrum, a spectral hardening at 600 GeV has been observed, along with a softening at 29 TeV measured with a 6.6{\sigma} significance. Moreover, the detector features and the analysis approach allowed for the extension of the spectral measurement up to the sub-PeV region. Even if with small statistical significance due to the low number of events, data suggest a new spectral hardening at about 150 TeV., Comment: Published on PRD

Published
2023
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12. Machine-learning-guided recognition of α and β cells from label-free infrared micrographs of living human islets of Langerhans

Author

Fabio Azzarello, Francesco Carli, Valentina De Lorenzi, Marta Tesi, Piero Marchetti, Fabio Beltram, Francesco Raimondi, and Francesco Cardarelli

Subjects
Medicine, Science
Abstract

Abstract Human islets of Langerhans are composed mostly of glucagon-secreting α cells and insulin-secreting β cells closely intermingled one another. Current methods for identifying α and β cells involve either fixing islets and using immunostaining or disaggregating islets and employing flow cytometry for classifying α and β cells based on their size and autofluorescence. Neither approach, however, allows investigating the dynamic behavior of α and β cells in a living and intact islet. To tackle this issue, we present a machine-learning-based strategy for identification α and β cells in label-free infrared micrographs of living human islets without immunostaining. Intrinsic autofluorescence is stimulated by infrared light and collected both in intensity and lifetime in the visible range, dominated by NAD(P)H and lipofuscin signals. Descriptive parameters are derived from micrographs for ~ 103 cells. These parameters are used as input for a boosted decision-tree model (XGBoost) pre-trained with immunofluorescence-derived cell-type information. The model displays an optimized-metrics performance of 0.86 (i.e. area under a ROC curve), with an associated precision of 0.94 for the recognition of β cells and 0.75 for α cells. This tool promises to enable longitudinal studies on the dynamic behavior of individual cell types at single-cell resolution within the intact tissue.

Published
2024
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13. Search for relativistic fractionally charged particles in space

Author

DAMPE Collaboration, Alemanno, F., Altomare, C., An, Q., Azzarello, P., Barbato, F. C. T., Bernardini, P., Bi, X. J., Cai, M. S., Casilli, E., Catanzani, E., Chang, J., Chen, D. Y., Chen, J. L., Chen, Z. F., Cui, M. Y., Cui, T. S., Cui, Y. X., Dai, H. T., De-Benedittis, A., De Mitri, I., de Palma, F., Deliyergiyev, M., Di Giovanni, A., Di Santo, M., Ding, Q., Dong, T. K., Dong, Z. X., Donvito, G., Droz, D., Duan, J. L., Duan, K. K., D'Urso, D., Fan, R. R., Fan, Y. Z., Fang, F., Fang, K., Feng, C. Q., Feng, L., Alonso, M. F., Frieden, J. M., Fusco, P., Gao, M., Gargano, F., Gong, K., Gong, Y. Z., Guo, D. Y., Guo, J. H., Han, S. X., Hu, Y. M., Huang, G. S., Huang, X. Y., Huang, Y. Y., Ionica, M., Jiang, L. Y., Jiang, W., Kong, J., Kotenko, A., Kyratzis, D., Lei, S. J., Li, W. L., Li, W. H., Li, X., Li, X. Q., Liang, Y. M., Liu, C. M., Liu, H., Liu, J., Liu, S. B., Liu, Y., Loparco, F., Luo, C. N., Ma, M., Ma, P. X., Ma, T., Ma, X. Y., Marsella, G., Mazziotta, M. N., Mo, D., Salinas, M. M., Niu, X. Y., Pan, X., Parenti, A., Peng, W. X., Peng, X. Y., Perrina, C., Qiao, R., Rao, J. N., Ruina, A., Shangguan, Z., Shen, W. H., Shen, Z. Q., Shen, Z. T., Silveri, L., Song, J. X., Stolpovskiy, M., Su, H., Su, M., Sun, H. R., Sun, Z. Y., Surdo, A., Teng, X. J., Tykhonov, A., Wang, J. Z., Wang, L. G., Wang, S., Wang, S. X., Wang, X. L., Wang, Y., Wang, Y. F., Wang, Y. Z., Wei, D. M., Wei, J. J., Wei, Y. F., Wu, D., Wu, J., Wu, L. B., Wu, S. S., Wu, X., Xia, Z. Q., Xu, E. H., Xu, H. T., Xu, J., Xu, Z. H., Xu, Z. L., Xu, Z. Z., Xue, G. F., Yang, H. B., Yang, P., Yang, Y. Q., Yao, H. J., Yu, Y. H., Yuan, G. W., Yuan, Q., Yue, C., Zang, J. J., Zhang, S. X., Zhang, W. Z., Zhang, Yan, Zhang, Yi., Zhang, Y. J., Zhang, Y. L., Zhang, Y. P., Zhang, Y. Q., Zhang, Z., Zhang, Z. Y., Zhao, C., Zhao, H. Y., Zhao, X. F., Zhou, C. Y., and Zhu, Y.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment, High Energy Physics - Phenomenology, Physics - Space Physics
Abstract

More than a century after the performance of the oil drop experiment, the possible existence of fractionally charged particles FCP still remains unsettled. The search for FCPs is crucial for some extensions of the Standard Model in particle physics. Most of the previously conducted searches for FCPs in cosmic rays were based on experiments underground or at high altitudes. However, there have been few searches for FCPs in cosmic rays carried out in orbit other than AMS-01 flown by a space shuttle and BESS by a balloon at the top of the atmosphere. In this study, we conduct an FCP search in space based on on-orbit data obtained using the DArk Matter Particle Explorer (DAMPE) satellite over a period of five years. Unlike underground experiments, which require an FCP energy of the order of hundreds of GeV, our FCP search starts at only a few GeV. An upper limit of $6.2\times 10^{-10}~~\mathrm{cm^{-2}sr^{-1} s^{-1}}$ is obtained for the flux. Our results demonstrate that DAMPE exhibits higher sensitivity than experiments of similar types by three orders of magnitude that more stringently restricts the conditions for the existence of FCP in primary cosmic rays., Comment: 19 pages, 6 figures, accepted by PRD

Published
2022
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15. Perceived Life-Readiness from Real-World Curriculum Experiences of Alumni

Author

Azzarello, Caterina Belle, Arakawa, Lee, Edi, Daniel, Sutton, Madasyn, and Larkins, Randy

Abstract

Students pursue college degrees expecting to learn skills necessary to navigate adult life. While this is the expectation of most students, there is a lack of research examining the perceived effectiveness of real-world applicability in undergraduate degrees. Objective: The purpose of this phenomenological and constructivist study was to explore how college alumni perceive their educational experiences in terms of real-world preparedness. Methods: Eight participants in their mid-twenties (5 females, 3 males) were selected using purposeful sampling. Participants participated in informal, semi-structured, one-on-one Zoom interviews and demographic questionnaire responses. Results: Emerging themes indicated that alumni felt the relationships formed had a greater contribution to their life-readiness compared to their real-world curriculum. Other emerging themes revealed alumni believed they developed valuable skills through hands-on experience and group work. Recommendations were made by alumni for curriculum changes, including smaller class sizes and inclusion of more practical courses. Conclusions: Based on these findings, future research should aim to replicate this study using a broader range of alumni to further investigate this phenomenon, as well as studies that investigate various college types and student experiences.

Published
2021

16. Follow-up of early breast cancer in a public health system: A 2024 AIGOM consensus project

Author

Gori, Stefania, De Rose, Fiorenza, Ferro, Antonella, Fabi, Alessandra, Angiolini, Catia, Azzarello, Giuseppe, Cancian, Maurizio, Cinquini, Michela, Arecco, Luca, Aristei, Cynthia, Bernardi, Daniela, Biganzoli, Laura, Cariello, Anna, Cortesi, Laura, Cretella, Elisabetta, Criscitiello, Carmen, De Giorgi, Ugo, Carmen De Santis, Maria, Deledda, Giuseppe, Dessena, Massimo, Donati, Sara, Dri, Arianna, Ferretti, Gianluigi, Foglietta, Jennifer, Franceschini, Davide, Franco, Pierfrancesco, Schirone, Alessio, Generali, Daniele, Gianni, Lorenzo, Giordani, Stefano, Grandi, Giovanni, Cristina Leonardi, Maria, Magno, Stefano, Malorni, Luca, Mantoan, Carlotta, Martorana, Federica, Meattini, Icro, Meduri, Bruno, Merlini, Laura, Miglietta, Federica, Modena, Alessandra, Nicolis, Fabrizio, Palumbo, Isabella, Panizza, Pietro, Angela Rovera, Francesca, Salvini, Piermario, Santoro, Armando, Taffurelli, Mario, Toss, Angela, Tralongo, Paolo, Turazza, Monica, Valerio, Matteo, Verzè, Matteo, Vici, Patrizia, Zamagni, Claudio, Curigliano, Giuseppe, Pappagallo, Giovanni, and Zambelli, Alberto

Published
2024
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19. Search for gamma-ray spectral lines with the DArk Matter Particle Explorer

Author

Alemanno, Francesca, An, Qi, Azzarello, Philipp, Barbato, Felicia Carla Tiziana, Bernardini, Paolo, Bi, Xiao-Jun, Cai, Ming-Sheng, Casilli, Elisabetta, Catanzani, Enrico, Chang, Jin, Chen, Deng-Yi, Chen, Jun-Ling, Chen, Zhan-Fang, Cui, Ming-Yang, Cui, Tian-Shu, Cui, Yu-Xing, Dai, Hao-Ting, De Benedittis, Antonio, De Mitri, Ivan, de Palma, Francesco, Deliyergiyev, Maksym, Di Santo, Margherita, Ding, Qi, Dong, Tie-Kuang, Dong, Zhen-Xing, Donvito, Giacinto, Droz, David, Duan, Jing-Lai, Duan, Kai-Kai, D'Urso, Domenico, Fan, Rui-Rui, Fan, Yi-Zhong, Fang, Fang, Fang, Kun, Feng, Chang-Qing, Feng, Lei, Fusco, Piergiorgio, Gao, Min, Gargano, Fabio, Gong, Ke, Gong, Yi-Zhong, Guo, Dong-Ya, Guo, Jian-Hua, Han, Shuang-Xue, Hu, Yi-Ming, Huang, Guang-Shun, Huang, Xiao-Yuan, Huang, Yong-Yi, Ionica, Maria, Jiang, Wei, Kong, Jie, Kotenko, Andrii, Kyratzis, Dimitrios, Lei, Shi-Jun, Li, Shang, Li, Wen-Hao, Li, Wei-Liang, Li, Xiang, Li, Xian-Qiang, Liang, Yao-Ming, Liu, Cheng-Ming, Liu, Hao, Liu, Jie, Liu, Shu-Bin, Liu, Yang, Loparco, Francesco, Luo, Chuan-Ning, Ma, Miao, Ma, Peng-Xiong, Ma, Tao, Ma, Xiao-Yong, Marsella, Giovanni, Mazziotta, Mario Nicola, Mo, Dan, Mu, Maria, Niu, Xiao-Yang, Pan, Xu, Parenti, Andrea, Peng, Wen-Xi, Peng, Xiao-Yan, Perrina, Chiara, Qiao, Rui, Rao, Jia-Ning, Ruina, Arshia, Shangguan, Zhi, Shen, Wei-Hua, Shen, Zhao-Qiang, Shen, Zhong-Tao, Silveri, Leandro, Song, Jing-Xing, Stolpovskiy, Mikhail, Su, Hong, Su, Meng, Sun, Hao-Ran, Sun, Zhi-Yu, Surdo, Antonio, Teng, Xue-Jian, Tykhonov, Andrii, Wang, Jin-Zhou, Wang, Lian-Guo, Wang, Shen, Wang, Shu-Xin, Wang, Xiao-Lian, Wang, Ying, Wang, Yan-Fang, Wang, Yuan-Zhu, Wei, Da-Ming, Wei, Jia-Ju, Wei, Yi-Feng, Wu, Di, Wu, Jian, Wu, Li-Bo, Wu, Sha-Sha, Wu, Xin, Xia, Zi-Qing, Xu, En-Heng, Xu, Hai-Tao, Xu, Zhi-Hui, Xu, Zun-Lei, Xu, Zi-Zong, Xue, Guo-Feng, Yang, Hai-Bo, Yang, Peng, Yang, Ya-Qing, Yao, Hui-Jun, Yu, Yu-Hong, Yuan, Guan-Wen, Yuan, Qiang, Yue, Chuan, Zang, Jing-Jing, Zhang, Sheng-Xia, Zhang, Wen-Zhang, Zhang, Yan, Zhang, Yi, Zhang, Yong-Jie, Zhang, Yun-Long, Zhang, Ya-Peng, Zhang, Yong-Qiang, Zhang, Zhe, Zhang, Zhi-Yong, Zhao, Cong, Zhao, Hong-Yun, Zhao, Xun-Feng, Zhou, Chang-Yi, Zhu, Yan, and Liang, Yun-Feng

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract

The DArk Matter Particle Explorer (DAMPE) is well suitable for searching for monochromatic and sharp $\gamma$-ray structures in the GeV$-$TeV range thanks to its unprecedented high energy resolution. In this work, we search for $\gamma$-ray line structures using five years of DAMPE data. To improve the sensitivity, we develop two types of dedicated data sets (including the BgoOnly data which is the first time to be used in the data analysis for the calorimeter-based gamma-ray observatories) and adopt the signal-to-noise ratio optimized regions of interest (ROIs) for different DM density profiles. No line signals or candidates are found between 10 and 300 GeV in the Galaxy. The constraints on the velocity-averaged cross section for $\chi\chi \to \gamma\gamma$ and the decay lifetime for $\chi \to \gamma\nu$, both at 95% confidence level, have been calculated and the systematic uncertainties have been taken into account. Comparing to the previous Fermi-LAT results, though DAMPE has an acceptance smaller by a factor of $\sim 10$, similar constraints on the DM parameters are achieved and below 100 GeV the lower limits on the decay lifetime are even stronger by a factor of a few. Our results demonstrate the potential of high-energy-resolution observations on dark matter detection., Comment: 14 pages, 8 figures. Update the content to keep up with the published version

Published
2021
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20. Observations of Forbush Decreases of cosmic ray electrons and positrons with the Dark Matter Particle Explorer

Author

Alemanno, Francesca, An, Qi, Azzarello, Philipp, Barbato, Felicia Carla Tiziana, Bernardini, Paolo, Bi, XiaoJun, Cai, MingSheng, Casilli, Elisabetta, Catanzani, Enrico, Chang, Jin, Chen, DengYi, Chen, JunLing, Chen, ZhanFang, Cui, MingYang, Cui, TianShu, Cui, YuXing, Dai, HaoTing, De Benedittis, Antonio, De Mitri, Ivan, de Palma, Francesco, Deliyergiyev, Maksym, Di Santo, Margherita, Ding, Qi, Dong, TieKuang, Dong, ZhenXing, Donvito, Giacinto, Droz, David, Duan, JingLai, Duan, KaiKai, D'Urso, Domenico, Fan, RuiRui, Fan, YiZhong, Fang, Fang, Fang, Kun, Feng, ChangQing, Feng, Lei, Fusco, Piergiorgio, Gao, Min, Gargano, Fabio, Gong, Ke, Gong, YiZhong, Guo, DongYa, Guo, JianHua, Han, ShuangXue, Hu, YiMing, Huang, GuangShun, Huang, XiaoYuan, Huang, YongYi, Ionica, Maria, Jiang, Wei, Kong, Jie, Kotenko, Andrii, Kyratzis, Dimitrios, Li, ., Lei, ShiJun, Li, WenHao, Li, WeiLiang, Li, Xiang, Li, XianQiang, Liang, YaoMing, Liu, ChengMing, Liu, Hao, Liu, Jie, Liu, ShuBin, Liu, Yang, Loparco, Francesco, Luo, ChuanNing, Ma, Miao, Ma, PengXiong, Ma, Tao, Ma, XiaoYong, Marsella, Giovanni, Mazziotta, Mario Nicola, Mo, Dan, Niu, XiaoYang, Pan, Xu, Parenti, Andrea, Peng, WenXi, Peng, XiaoYan, Perrina, Chiara, Qiao, Rui, Rao, JiaNing, Ruina, Arshia, Salinas, MariaMunoz, Shangguan, Zhi, Shen, WeiHua, Shen, ZhaoQiang, Shen, ZhongTao, Silveri, Leandro, Song, JingXing, Stolpovskiy, Mikhail, Su, Hong, Su, Meng, Sun, HaoRan, Sun, ZhiYu, Surdo, Antonio, Teng, XueJian, Tykhonov, Andrii, Wang, JinZhou, Wang, LianGuo, Wang, Shen, Wang, ShuXin, Wang, XiaoLian, Wang, Ying, Wang, YanFang, Wang, YuanZhu, Wei, DaMing, Wei, JiaJu, Wei, YiFeng, Wu, Di, Wu, Jian, Wu, LiBo, Wu, Sha Sha, Wu, Xin, Xia, ZiQing, Xu, EnHeng, Xu, HaiTao, Xu, ZhiHui, Xu, ZunLei, Xue, GuoFeng, Xu, ZiZong, Yang, HaiBo, Yang, Peng, Yang, YaQing, Yao, Hui Jun, Yu, YuHong, Yuan, GuanWen, Yuan, Qiang, Yue, Chuan, Zang, JingJing, Zhang, ShengXia, Zhang, WenZhang, Zhang, Yan, Zhang, Yi, Zhang, YongJie, Zhang, YunLong, Zhang, YaPeng, Zhang, YongQiang, Zhang, ZhiYong, Zhang, Zhe, Zhao, Cong, Zhao, HongYun, Zhao, XunFeng, Zhou, ChangYi, Zhu, Yan, Chen, Wei, Feng, Li, Luo, Xi, and Zhu, ChengRui

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The Forbush Decrease (FD) represents the rapid decrease of the intensities of charged particles accompanied with the coronal mass ejections (CMEs) or high-speed streams from coronal holes. It has been mainly explored with ground-based neutron monitors network which indirectly measure the integrated intensities of all species of cosmic rays by counting secondary neutrons produced from interaction between atmosphere atoms and cosmic rays. The space-based experiments can resolve the species of particles but the energy ranges are limited by the relative small acceptances except for the most abundant particles like protons and helium. Therefore, the FD of cosmic ray electrons and positrons have just been investigated by the PAMELA experiment in the low energy range ($<5$ GeV) with limited statistics. In this paper, we study the FD event occurred in September, 2017, with the electron and positron data recorded by the Dark Matter Particle Explorer. The evolution of the FDs from 2 GeV to 20 GeV with a time resolution of 6 hours are given. We observe two solar energetic particle events in the time profile of the intensity of cosmic rays, the earlier and weak one has not been shown in the neutron monitor data. Furthermore, both the amplitude and recovery time of fluxes of electrons and positrons show clear energy-dependence, which is important in probing the disturbances of the interplanetary environment by the coronal mass ejections., Comment: This article is dedicated to the 72nd anniversary of People's Republic of China

Published
2021
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22. Characterization of water-soluble brown carbon chromophores from wildfire plumes in the western USA using size-exclusion chromatography

Author

L. Azzarello, R. A. Washenfelder, M. A. Robinson, A. Franchin, C. C. Womack, C. D. Holmes, S. S. Brown, A. Middlebrook, T. Newberger, C. Sweeney, and C. J. Young

Subjects
Physics, QC1-999, Chemistry, QD1-999
Abstract

Wildfires are an important source of carbonaceous aerosol in the atmosphere. Organic aerosol that absorbs light in the ultraviolet to visible spectral range is referred to as brown carbon (BrC), and its impact on Earth's radiative budget has not been well characterized. We collected water-soluble brown carbon using a particle-into-liquid sampler (PILS) on board a Twin Otter aircraft during the Fire Influence on Regional to Global Environments and Air Quality (FIREX-AQ) campaign. Samples were collected downwind of wildfires in the western United States from August to September 2019. We applied size-exclusion chromatography (SEC) with ultraviolet-visible spectroscopy to characterize the molecular size distribution of BrC chromophores. The wildfire plumes had transport ages of 0 to 5 h, and the absorption was dominated by chromophores with molecular weights Da. With BrC normalized to a conserved biomass burning tracer, carbon monoxide, a consistent decrease in BrC absorption with plume age was not observed during FIREX-AQ. These findings are consistent with the variable trends in BrC absorption with plume age reported in recent studies. While BrC absorption trends were broadly consistent between the offline SEC analysis and the online PILS measurements, the absolute values of absorption and their spectral dependence differed. We investigate plausible explanations for the discrepancies observed between the online and offline analyses. This included solvent effects, pH, and sample storage. We suspect that sample storage impacted the absorption intensity of the offline measurements without impacting the molecular weight distribution of BrC chromophores.

Published
2023
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23. Measurement of the cosmic ray helium energy spectrum from 70 GeV to 80 TeV with the DAMPE space mission

Author

Alemanno, F., An, Q., Azzarello, P., Barbato, F. C. T., Bernardini, P., Bi, X. J., Cai, M. S., Catanzani, E., Chang, J., Chen, D. Y., Chen, J. L., Chen, Z. F., Cui, M. Y., Cui, T. S., Cui, Y. X., Dai, H. T., D'Amone, A., De Benedittis, A., De Mitri, I., de Palma, F., Deliyergiyev, M., Di Santo, M., Dong, T. K., Dong, Z. X., Donvito, G., Droz, D., Duan, J. L., Duan, K. K., D'Urso, D., Fan, R. R., Fan, Y. Z., Fang, K., Fang, F., Feng, C. Q., Feng, L., Fusco, P., Gao, M., Gargano, F., Gong, K., Gong, Y. Z., Guo, D. Y., Guo, J. H., Guo, X. L., Han, S. X., Hu, Y. M., Huang, G. S., Huang, X. Y., Huang, Y. Y., Ionica, M., Jiang, W., Kong, J., Kotenko, A., Kyratzis, D., Lei, S. J., Li, S., Li, W. L., Li, X., Li, X. Q., Liang, Y. M., Liu, C. M., Liu, H., Liu, J., Liu, S. B., Liu, W. Q., Liu, Y., Loparco, F., Luo, C. N., Ma, M., Ma, P. X., Ma, T., Ma, X. Y., Marsella, G., Mazziotta, M. N., Mo, D., Niu, X. Y., Pan, X., Parenti, A., Peng, W. X., Peng, X. Y., Perrina, C., Qiao, R., Rao, J. N., Ruina, A., Salinas, M. M., Shang, G. Z., Shen, W. H., Shen, Z. Q., Shen, Z. T., Silveri, L., Song, J. X., Stolpovskiy, M., Su, H., Su, M., Sun, Z. Y., Surdo, A., Teng, X. J., Tykhonov, A., Wang, H., Wang, J. Z., Wang, L. G., Wang, S., Wang, X. L., Wang, Y., Wang, Y. F., Wang, Y. Z., Wang, Z. M., Wei, D. M., Wei, J. J., Wei, Y. F., Wen, S. C., Wu, D., Wu, J., Wu, L. B., Wu, S. S., Wu, X., Xia, Z. Q., Xu, H. T., Xu, Z. H., Xu, Z. L., Xu, Z. Z., Xue, G. F., Yang, H. B., Yang, P., Yang, Y. Q., Yao, H. J., Yu, Y. H., Yuan, G. W., Yuan, Q., Yue, C., Zang, J. J., Zhang, F., Zhang, S. X., Zhang, W. Z., Zhang, Y., Zhang, Y. J., Zhang, Y. L., Zhang, Y. P., Zhang, Y. Q., Zhang, Z., Zhang, Z. Y., Zhao, C., Zhao, H. Y., Zhao, X. F., Zhou, C. Y., and Zhu, Y.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract

The measurement of the energy spectrum of cosmic ray helium nuclei from 70 GeV to 80 TeV using 4.5 years of data recorded by the DArk Matter Particle Explorer (DAMPE) is reported in this work. A hardening of the spectrum is observed at an energy of about 1.3 TeV, similar to previous observations. In addition, a spectral softening at about 34 TeV is revealed for the first time with large statistics and well controlled systematic uncertainties, with an overall significance of $4.3\sigma$. The DAMPE spectral measurements of both cosmic protons and helium nuclei suggest a particle charge dependent softening energy, although with current uncertainties a dependence on the number of nucleons cannot be ruled out., Comment: 11 pages, 13 figures, published in Phys. Rev. Lett. Add one more digit for first three columns in Table S2

Published
2021
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24. Follow-up of breast cancer: why is it necessary to start a Consensus in 2024?

Author

Stefania Gori, Alberto Zambelli, Catia Angiolini, Antonella Ferro, Fiorenza De Rose, Alessandra Fabi, Giuseppe Azzarello, Giuseppe Bogina, Maurizio Cancian, Matteo Valerio, Michela Cinquini, Fabrizio Nicolis, and Giovanni Pappagallo

Subjects
Consensus, Early breast cancer, Follow-up, Mini-Delphi methodology, Medicine
Abstract

In Italy, breast cancer is the most frequently diagnosed cancer in women, with 55,900 new cases in 2023 (over 90% in the early stages). Due to the screening, early diagnosis and adjuvant treatment, these patients have a 5-years survival rate of 87% after the diagnosis. There are 834,154 women in Italy with a previous diagnosis of breast cancer: most of these women require a follow-up. The AIOM, ESMO and ASCO Guidelines recommend for early breast cancer (EBC) a clinical follow-up with only physical examination (and eliciting of symptoms) and an annual X-ray mammography, on the basis of the results of two randomized trials published in 1994 that showed no benefit in overall survival with intensive follow-up. However, an Italian survey reported the application by 80% of oncologists of an intensive follow-up based on the individual patient’s risk of recurrence. In fact, the oncologists believe that an early diagnosis of locoregional or distant recurrence may allow an early start of very effective therapies. In this lack of up-to-date scientific data, many questions about follow-up remain unanswered and the few ongoing studies will provide results in several years. Non-compliance with guideline recommendations leads to increased costs for the healthcare system. Furthermore, management varies widely from centre to centre with regard to guideline recommendations, resulting in inequalities between patients. For these reasons, the follow-up of breast cancer should be reconsidered. In the absence of recent scientific evidence, a multidisciplinary group of breast cancer experts has initiated a Consensus on the follow-up of EBC according to the mini-Delphi methodology. The project will be completed by the end of 2024.

Published
2024
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25. Tracker-In-Calorimeter (TIC): a calorimetric approach to tracking gamma rays in space experiments

Author

Adriani, O., Ambrosi, G., Azzarello, P., Basti, A., Berti, E., Bertucci, B., Bigongiari, G., Bonechi, L., Bongi, M., Bottai, S., Brianzi, M., Brogi, P., Castellini, G., Catanzani, E., Checchia, C., D'Alessandro, R., Detti, S., Duranti, M., Finetti, N., Formato, V., Ionica, M., Maestro, P., Maletta, F., Marrocchesi, P. S., Mori, N., Pacini, L., Papini, P., Ricciarini, S., Silvestre, G., Spillantini, P., Starodubtsev, O., Stolzi, F., Suh, J. E., Sulaj, A., Tiberio, A., and Vannuccini, E.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

A multi-messenger, space-based cosmic ray detector for gamma rays and charged particles poses several design challenges due to the different instrumental requirements for the two kind of particles. Gamma-ray detection requires layers of high Z materials for photon conversion and a tracking device with a long lever arm to achieve the necessary angular resolution to separate point sources; on the contrary, charge measurements for atomic nuclei requires a thin detector in order to avoid unwanted fragmentation, and a shallow instrument so to maximize the geometric factor. In this paper, a novel tracking approach for gamma rays which tries to reconcile these two conflicting requirements is presented. The proposal is based on the Tracker-In-Calorimeter (TIC) design that relies on a highly-segmented calorimeter to track the incident gamma ray by sampling the lateral development of the electromagnetic shower at different depths. The effectiveness of this approach has been studied with Monte Carlo simulations and has been validated with test beam data of a detector prototype., Comment: 17 pages, 8 figures, 2 tables

Published
2020
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26. Reassembling the sacred : the Murano Master and the illuminated choir books of Camaldolese House of San Mattia di Murano

Author

Azzarello, Stephanie, Cooper, Donal, and Panayotova, Stella

Subjects
Art History, Illuminated Manuscripts, Camaldolese Liturgy, Quattrocento Italy, Master of the Murano Gradual, Cristoforo Cortese, Venice, San Mattia di Murano, San Michele in Isola, Late Medieval, Early Modern
Abstract

This dissertation presents a partial reconstruction of a now-dismembered series of lavishly illuminated and large-scale choir books made for the Camaldolese monastery of San Mattia di Murano ca. 1400-ca. 1445. These manuscripts are attributed to Cristoforo Cortese and the so-called 'Master of the Murano Gradual,' and now exist as two intact volumes and thirty-eight excised historiated initials found in public and private collections all over the globe. This thesis mines the dense, visual religious elements of these understudied images in order to investigate the use of monastic corporate iconography by the monks at San Mattia. In this thesis, I argue that the brothers at San Mattia commissioned these manuscripts, not only as necessary liturgical tools, but also as a means of expressing complex ideas about self-identity within both Benedictine monasticism and Christianity, more broadly. This thesis also examines and compares the iconographic programme and stylistic features of the San Mattia volumes with choir books belonging to its nearby sister house San Michele in Isola, and with the lavish series owned by a third Camaldolese monastery: Santa Maria degli Angeli in Florence, whose manuscripts were a model for both the sets commissioned for the houses in the Venetian lagoon. The results of this analysis show that the monks at San Mattia appear to have wanted their choir books' visual scheme to reflect spiritual values and ideas with specific significance for their own house and which deviate from the iconographic model of the Florentine series. This study also investigates the San Mattia visual corpus within the framework of select examples of monumental painting, particularly frescos and altarpieces, as a means of probing the influences of other media on the work of the Murano Master. Ultimately, this study not only offers the first-ever reconstruction of the San Mattia choir books, but it also provides new insights into their significance in terms of the Camaldolese use of monastic corporate iconography within the context of early Quattrocento Venice.

Published
2021
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27. Cardiac wasting in head and neck cancer and in cardiac autopsies from different cancer types: A study in a chemo‐naïve setting

Author

Sara Calamelli, Samantha Noto, Alessandra Baldoni, Alessandra Casarin, Alessandro Calzavara, Irene Bolgan, Silvia Coccato, Salvatore Saccà, Licia Laurino, Giuseppe Azzarello, and Simonetta Ausoni

Subjects
Autoptic analysis, Cardiac wasting, Chemo‐naive patients, Head and neck cancer, Left ventricular wall thickness, Diseases of the musculoskeletal system, RC925-935, Human anatomy, QM1-695
Abstract

Abstract Background Cardiac wasting is a detrimental consequence of cancer that has been traditionally ignored and often misinterpreted as an iatrogenic effect. Methods We conducted a retrospective study on 42 chemo‐naive patients affected by locally advanced head and neck cancer (HNC). Based on unintentional weight loss, patients were divided into cachectic and non‐cachectic. Left ventricular mass (LVM), LV wall thickness (LVWT), interventricular septal (IVS) thickness, left ventricular internal diameter diastolic (LVIDd), left ventricular internal diameter systolic (LVIDs), internal ventricular septum diastolic (IVSd), left ventricular posterior wall thickness diastolic (LVPWd) and LV ejection fraction (LVEF) were analysed by echocardiography. In parallel, we retrospectively analysed 28 cardiac autoptic specimens of patients who either died of cancer before chemotherapy or with a diagnosis of cancer at autopsy. Presence or absence of myocardial fibrosis at microscopic observation was used for sample stratification. Conventional histology was performed. Results Cachectic and non‐cachectic patients had a significantly different value of LVWT and IVS thickness and LVPWd. LVWT was 9.08 ± 1.57 versus 10.35 ± 1.41 mm (P = 0.011) in cachectic and non‐cachectic patients, IVS was 10.00 mm (8.50–11.00) versus 11.00 mm (10.00–12.00) (P = 0.035), and LVPWd was 9.0 (8.5–10.0) and 10.00 mm (9.5–11.0) (P = 0.019) in cachectic and non‐cachectic patients. LVM adjusted for body surface area or height squared did not differ between the two populations. Similarly, LVEF did not show any significant decline. At multivariate logistic regression analysis for some independent predictors of weight loss, only LVWT maintained significant difference between cachectic and non‐cachectic patients (P = 0.035, OR = 0.240; P = 0.019). The secondary analysis on autoptic specimens showed no significant change in heart weight, whereas LVWT declined from 9.50 (7.25–11.00) to 7.50 mm (6.00–9.00) in cardiac specimens with myocardial fibrosis (P = 0.043). These data were confirmed in multivariate logistic regression analysis (P = 0.041, OR = 0.502). Histopathological analysis confirmed severe atrophy of cardiomyocytes, fibrosis and oedema as compared with controls. Conclusions Subtle changes in heart structure and function occur early in HNC patients. These can be detected with routine echocardiography and may help to select appropriate cancer treatment regimens for these patients. Histopathological analysis provided conclusive evidence that atrophy of cardiomyocytes, oedema and fibrosis occur during cancer progression and may precede the onset of overt cardiac pathology. To our knowledge, this is the first clinical study that establishes a direct relationship between tumour progression and cardiac remodelling in HNCs and the first pathological study conducted on human cardiac autopsies from selected chemo‐naïve cancer patients.

Published
2023
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28. Measurement of the cosmic-ray proton spectrum from 40 GeV to 100 TeV with the DAMPE satellite

Author

An, Q., Asfandiyarov, R., Azzarello, P., Bernardini, P., Bi, X. J., Cai, M. S., Chang, J., Chen, D. Y., Chen, H. F., Chen, J. L., Chen, W., Cui, M. Y., Cui, T. S., Dai, H. T., D'Amone, A., De Benedittis, A., De Mitri, I., Di Santo, M., Ding, M., Dong, T. K., Dong, Y. F., Dong, Z. X., Donvito, G., Droz, D., Duan, J. L., Duan, K. K., D'Urso, D., Fan, R. R., Fan, Y. Z., Fang, F., Feng, C. Q., Feng, L., Fusco, P., Gallo, V., Gan, F. J., Gao, M., Gargano, F., Gong, K., Gong, Y. Z., Guo, D. Y., Guo, J. H., Guo, X. L., Han, S. X., Hu, Y. M., Huang, G. S., Huang, X. Y., Huang, Y. Y., Ionica, M., Jiang, W., Jin, X., Kong, J., Lei, S. J., Li, S., Li, W. L., Li, X., Li, X. Q., Li, Y., Liang, Y. F., Liang, Y. M., Liao, N. H., Liu, C. M., Liu, H., Liu, J., Liu, S. B., Liu, W. Q., Liu, Y., Loparco, F., Luo, C. N., Ma, M., Ma, P. X., Ma, S. Y., Ma, T., Ma, X. Y., Marsella, G., Mazziotta, M. N., Mo, D., Niu, X. Y., Pan, X., Peng, W. X., Peng, X. Y., Qiao, R., Rao, J. N., Salinas, M. M., Shang, G. Z., Shen, W. H., Shen, Z. Q., Shen, Z. T., Song, J. X., Su, H., Su, M., Sun, Z. Y., Surdo, A., Teng, X. J., Tykhonov, A., Vitillo, S., Wang, C., Wang, H., Wang, H. Y., Wang, J. Z., Wang, L. G., Wang, Q., Wang, S., Wang, X. H., Wang, X. L., Wang, Y. F., Wang, Y. P., Wang, Y. Z., Wang, Z. M., Wei, D. M., Wei, J. J., Wei, Y. F., Wen, S. C., Wu, D., Wu, J., Wu, L. B., Wu, S. S., Wu, X., Xi, K., Xia, Z. Q., Xu, H. T., Xu, Z. H., Xu, Z. L., Xu, Z. Z., Xue, G. F., Yang, H. B., Yang, P., Yang, Y. Q., Yang, Z. L., Yao, H. J., Yu, Y. H., Yuan, Q., Yue, C., Zang, J. J., Zhang, F., Zhang, J. Y., Zhang, J. Z., Zhang, P. F., Zhang, S. X., Zhang, W. Z., Zhang, Y., Zhang, Y. J., Zhang, Y. L., Zhang, Y. P., Zhang, Y. Q., Zhang, Z., Zhang, Z. Y., Zhao, H., Zhao, H. Y., Zhao, X. F., Zhou, C. Y., Zhou, Y., Zhu, X., Zhu, Y., and Zimmer, S.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The precise measurement of the spectrum of protons, the most abundant component of the cosmic radiation, is necessary to understand the source and acceleration of cosmic rays in the Milky Way. This work reports the measurement of the cosmic ray proton fluxes with kinetic energies from 40 GeV to 100 TeV, with two and a half years of data recorded by the DArk Matter Particle Explorer (DAMPE). This is the first time an experiment directly measures the cosmic ray protons up to ~100 TeV with a high statistics. The measured spectrum confirms the spectral hardening found by previous experiments and reveals a softening at ~13.6 TeV, with the spectral index changing from ~2.60 to ~2.85. Our result suggests the existence of a new spectral feature of cosmic rays at energies lower than the so-called knee, and sheds new light on the origin of Galactic cosmic rays., Comment: 37 pages, 5 figures, published in Science Advances

Published
2019
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29. The on-orbit calibration of DArk Matter Particle Explorer

Author

Ambrosi, G., An, Q., Asfandiyarov, R., Azzarello, P., Bernardini, P., Cai, M. S., Caragiulo, M., Chang, J., Chen, D. Y., Chen, H. F., Chen, J. L., Chen, W., Cui, M. Y., Cui, T. S., Dai, H. T., D'Amone, A., De Benedittis, A., De Mitri, I., Ding, M., Di Santo, M., Dong, J. N., Dong, T. K., Dong, Y. F., Dong, Z. X., Droz, D., Duan, K. K., Duan, J. L., D'Urso, D., Fan, R. R., Fan, Y. Z., Fang, F., Feng, C. Q., Feng, L., Fusco, P., Gallo, V., Gan, F. J., Gao, M., Gao, S. S., Gargano, F., Garrappa, S., Gong, K., Gong, Y. Z., Guo, J. H., Hu, Y. M., Huang, G. S., Huang, Y. Y., Ionica, M., Jiang, D., Jiang, W., Jin, X., Kong, J., Lei, S. J., Li, S., Li, X., Li, W. L., Li, Y., Liang, Y. F., Liang, Y. M., Liao, N. H., Liu, C. M., Liu, H., Liu, J., Liu, S. B., Liu, W. Q., Liu, Y., Loparco, F., Ma, M., Ma, P. X., Ma, S. Y., Ma, T., Ma, X. Q., Ma, X. Y., Marsella, G., Mazziotta, M. N., Mo, D., Niu, X. Y., Pan, X., Peng, X. Y., Peng, W. X., Qiao, R., Rao, J. N., Salinas, M. M., Shang, G. Z., Shen, W. H., Shen, Z. Q., Shen, Z. T., Song, J. X., Su, H., Su, M., Sun, Z. Y., Surdo, A., Teng, X. J., Tian, X. B., Tykhonov, A., Vitillo, S., Wang, C., Wang, H., Wang, H. Y., Wang, J. Z., Wang, L. G., Wang, Q., Wang, S., Wang, X. H., Wang, X. L., Wang, Y. F., Wang, Y. P., Wang, Y. Z., Wang, Z. M., Wen, S. C., Wei, D. M., Wei, J. J., Wei, Y. F., Wu, D., Wu, J., Wu, L. B., Wu, S. S., Wu, X., Xi, K., Xia, Z. Q., Xin, Y. L., Xu, H. T., Xu, Z. H., Xu, Z. L., Xu, Z. Z., Xue, G. F., Yang, H. B., Yang, P., Yang, Y. Q., Yang, Z. L., Yao, H. J., Yu, Y. H., Yuan, Q., Yue, C., Zang, J. J., Zhang, D. L., Zhang, F., Zhang, J. B., Zhang, J. Y., Zhang, J. Z., Zhang, L., Zhang, P. F., Zhang, S. X., Zhang, W. Z., Zhang, Y., Zhang, Y. J., Zhang, Y. Q., Zhang, Y. L., Zhang, Y. P., Zhang, Z., Zhang, Z. Y., Zhao, H., Zhao, H. Y., Zhao, X. F., Zhou, C. Y., Zhou, Y., Zhu, X., Zhu, Y., and Zimmer, S.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract

The DArk Matter Particle Explorer (DAMPE), a satellite-based cosmic ray and gamma-ray detector, was launched on December 17, 2015, and began its on-orbit operation on December 24, 2015. In this work we document the on-orbit calibration procedures used by DAMPE and report the calibration results of the Plastic Scintillator strip Detector (PSD), the Silicon-Tungsten tracKer-converter (STK), the BGO imaging calorimeter (BGO), and the Neutron Detector (NUD). The results are obtained using Galactic cosmic rays, bright known GeV gamma-ray sources, and charge injection into the front-end electronics of each sub-detector. The determination of the boundary of the South Atlantic Anomaly (SAA), the measurement of the live time, and the alignments of the detectors are also introduced. The calibration results demonstrate the stability of the detectors in almost two years of the on-orbit operation.

Published
2019
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30. Penetrating particle ANalyzer (PAN)

Author

Wu, X., Ambrosi, G., Azzarello, P., Bergmann, B., Bertucci, B., Cadoux, F., Campbell, M., Duranti, M., Ionica, M., Kole, M., Krucker, S., Maehlum, G., Meier, D., Paniccia, M., Pinsky, L., Plainaki, C., Pospisil, S., Stein, T., Thonet, P. A., Tomassetti, N., and Tykhonov, A.

Subjects
Physics - Space Physics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

PAN is a scientific instrument suitable for deep space and interplanetary missions. It can precisely measure and monitor the flux, composition, and direction of highly penetrating particles ($> \sim$100 MeV/nucleon) in deep space, over at least one full solar cycle (~11 years). The science program of PAN is multi- and cross-disciplinary, covering cosmic ray physics, solar physics, space weather and space travel. PAN will fill an observation gap of galactic cosmic rays in the GeV region, and provide precise information of the spectrum, composition and emission time of energetic particle originated from the Sun. The precise measurement and monitoring of the energetic particles is also a unique contribution to space weather studies. PAN will map the flux and composition of penetrating particles, which cannot be shielded effectively, precisely and continuously, providing valuable input for the assessment of the related health risk, and for the development of an adequate mitigation strategy. PAN has the potential to become a standard on-board instrument for deep space human travel. PAN is based on the proven detection principle of a magnetic spectrometer, but with novel layout and detection concept. It will adopt advanced particle detection technologies and industrial processes optimized for deep space application. The device will require limited mass (~20 kg) and power (~20 W) budget. Dipole magnet sectors built from high field permanent magnet Halbach arrays, instrumented in a modular fashion with high resolution silicon strip detectors, allow to reach an energy resolution better than 10\% for nuclei from H to Fe at 1 GeV/n.

Published
2019
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31. Single-cell imaging of α and β cell metabolic response to glucose in living human Langerhans islets

Author

Fabio Azzarello, Luca Pesce, Valentina De Lorenzi, Gianmarco Ferri, Marta Tesi, Silvia Del Guerra, Piero Marchetti, and Francesco Cardarelli

Subjects
Biology (General), QH301-705.5
Abstract

A combination of live imaging and immunofluorescence on donor islet cells uncover an anti-correlation of enzyme-bound NAD(P)H and insulin secretion power.

Published
2022
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32. Characterization of a Large Area Hybrid Pixel Detector of Timepix3 Technology for Space Applications

Author

Martin Farkas, Benedikt Bergmann, Pavel Broulim, Petr Burian, Giovanni Ambrosi, Philipp Azzarello, Lukáš Pušman, Mateusz Sitarz, Petr Smolyanskiy, Daniil Sukhonos, and Xin Wu

Subjects
PAN, Timepix3 low-power modes, Timepix3 Quad, Timepix3 temperature dependency, Timpepix3 space application, Physics, QC1-999, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

We present the characterization of a highly segmented “large area” hybrid pixel detector (Timepix3, 512 × 512 pixels, pixel pitch 55 µm) for application in space experiments. We demonstrate that the nominal power consumption of 6 W can be reduced by changing the settings of the Timepix3 analog front-end and reducing the matrix clock frequency (from the nominal 40 MHz to 5 MHz) to 2 W (in the best case). We then present a comprehensive study of the impact of these changes on the particle tracking performance, the energy resolution and time stamping precision by utilizing data measured at the Super-Proton-Synchrotron (SPS) at CERN and at the Danish Center for Particle Therapy (DCPT). While the impact of the slower sampling frequency on energy measurement can be mitigated by prolongation of the falling edge of the analog signal, we find a reduction of the time resolution from 1.8 ns (in standard settings) to 5.6 ns (in analog low-power), which is further reduced utilizing a lower sampling clock (e.g., 5 MHz, in digital low-power operation) to 73.5 ns. We have studied the temperature dependence of the energy measurement for ambient temperatures between −20 °C and 50 °C separately for the different settings.

Published
2024
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33. In-flight performance of the DAMPE silicon tracker

Author

Tykhonov, A., Ambrosi, G., Asfandiyarov, R., Azzarello, P., Bernardini, P., Bertucci, B., Bolognini, A., Cadoux, F., D'Amone, A., De Benedittis, A., De Mitri, I., Di Santo, M., Dong, Y. F., Duranti, M., D'Urso, D., Fan, R. R., Fusco, P., Gallo, V., Gao, M., Gargano, F., Garrappa, S., Gong, K., Ionica, M., La Marra, D., Loparco, F., Marsella, G., Mazziotta, M. N., Peng, W. X., Qiao, R., Salinas, M. M., Surdo, A., Vagelli, V., Vitillo, S., Wang, H. Y., Wang, J. Z., Wang, Z. M., Wu, D., Wu, X., Zhang, F., Zhang, J. Y., Zhao, H., and Zimmer, S.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract

DAMPE (DArk Matter Particle Explorer) is a spaceborne high-energy cosmic ray and gamma-ray detector, successfully launched in December 2015. It is designed to probe astroparticle physics in the broad energy range from few GeV to 100 TeV. The scientific goals of DAMPE include the identification of possible signatures of Dark Matter annihilation or decay, the study of the origin and propagation mechanisms of cosmic-ray particles, and gamma-ray astronomy. DAMPE consists of four sub-detectors: a plastic scintillator strip detector, a Silicon-Tungsten tracKer-converter (STK), a BGO calorimeter and a neutron detector. The STK is composed of six double layers of single-sided silicon micro-strip detectors interleaved with three layers of tungsten for photon conversions into electron-positron pairs. The STK is a crucial component of DAMPE, allowing to determine the direction of incoming photons, to reconstruct tracks of cosmic rays and to estimate their absolute charge (Z). We present the in-flight performance of the STK based on two years of in-flight DAMPE data, which includes the noise behavior, signal response, thermal and mechanical stability, alignment and position resolution.

Published
2018
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34. De Novo Pathogenic Variants in N-cadherin Cause a Syndromic Neurodevelopmental Disorder with Corpus Collosum, Axon, Cardiac, Ocular, and Genital Defects

Author

Accogli, Andrea, Calabretta, Sara, St-Onge, Judith, Boudrahem-Addour, Nassima, Dionne-Laporte, Alexandre, Joset, Pascal, Azzarello-Burri, Silvia, Rauch, Anita, Krier, Joel, Fieg, Elizabeth, Pallais, Juan C, Network, Undiagnosed Diseases, Acosta, Maria T, Adams, David R, Agrawal, Pankaj, Alejandro, Mercedes E, Allard, Patrick, Alvey, Justin, Andrews, Ashley, Ashley, Euan A, Azamian, Mahshid S, Bacino, Carlos A, Bademci, Guney, Baker, Eva, Balasubramanyam, Ashok, Baldridge, Dustin, Bale, Jim, Barbouth, Deborah, Batzli, Gabriel F, Bayrak-Toydemir, Pinar, Beggs, Alan H, Bejerano, Gill, Bellen, Hugo J, Bernstein, Jonathan A, Berry, Gerard T, Bican, Anna, Bick, David P, Birch, Camille L, Bivona, Stephanie, Bohnsack, John, Bonnenmann, Carsten, Bonner, Devon, Boone, Braden E, Bostwick, Bret L, Botto, Lorenzo, Briere, Lauren C, Brokamp, Elly, Brown, Donna M, Brush, Matthew, Burke, Elizabeth A, Burrage, Lindsay C, Butte, Manish J, Carey, John, Carrasquillo, Olveen, Chang, Ta Chen Peter, Chao, Hsiao-Tuan, Clark, Gary D, Coakley, Terra R, Cobban, Laurel A, Cogan, Joy D, Cole, F Sessions, Colley, Heather A, Cooper, Cynthia M, Cope, Heidi, Craigen, William J, D’Souza, Precilla, Dasari, Surendra, Davids, Mariska, Dayal, Jyoti G, Dell’Angelica, Esteban C, Dhar, Shweta U, Dorrani, Naghmeh, Dorset, Daniel C, Douine, Emilie D, Draper, David D, Duncan, Laura, Eckstein, David J, Emrick, Lisa T, Eng, Christine M, Esteves, Cecilia, Estwick, Tyra, Fernandez, Liliana, Ferreira, Carlos, Fieg, Elizabeth L, Fisher, Paul G, Fogel, Brent L, Forghani, Irman, Fresard, Laure, Gahl, William A, Godfrey, Rena A, Goldman, Alica M, Goldstein, David B, Gourdine, Jean-Philippe F, Grajewski, Alana, Groden, Catherine A, Gropman, Andrea L, Haendel, Melissa, Hamid, Rizwan, Hanchard, Neil A, and Hayes, Nichole

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Genetics, Biological Sciences, Neurosciences, 2.1 Biological and endogenous factors, Aetiology, Axons, Cadherins, Corpus Callosum, Eye, Frameshift Mutation, Genitalia, Heart Defects, Congenital, Heterozygote, Humans, Neurodevelopmental Disorders, Undiagnosed Diseases Network, ACOG, CDH2, N-cadherin, cardiac defects, cell-cell adhesion, corpus callosum, eye defects, genital defects, intellectual disability, Medical and Health Sciences, Genetics & Heredity, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Cadherins constitute a family of transmembrane proteins that mediate calcium-dependent cell-cell adhesion. The extracellular domain of cadherins consists of extracellular cadherin (EC) domains, separated by calcium binding sites. The EC interacts with other cadherin molecules in cis and in trans to mechanically hold apposing cell surfaces together. CDH2 encodes N-cadherin, whose essential roles in neural development include neuronal migration and axon pathfinding. However, CDH2 has not yet been linked to a Mendelian neurodevelopmental disorder. Here, we report de novo heterozygous pathogenic variants (seven missense, two frameshift) in CDH2 in nine individuals with a syndromic neurodevelopmental disorder characterized by global developmental delay and/or intellectual disability, variable axon pathfinding defects (corpus callosum agenesis or hypoplasia, mirror movements, Duane anomaly), and ocular, cardiac, and genital anomalies. All seven missense variants (c.1057G>A [p.Asp353Asn]; c.1789G>A [p.Asp597Asn]; c.1789G>T [p.Asp597Tyr]; c.1802A>C [p.Asn601Thr]; c.1839C>G [p.Cys613Trp]; c.1880A>G [p.Asp627Gly]; c.2027A>G [p.Tyr676Cys]) result in substitution of highly conserved residues, and six of seven cluster within EC domains 4 and 5. Four of the substitutions affect the calcium-binding site in the EC4-EC5 interdomain. We show that cells expressing these variants in the EC4-EC5 domains have a defect in cell-cell adhesion; this defect includes impaired binding in trans with N-cadherin-WT expressed on apposing cells. The two frameshift variants (c.2563_2564delCT [p.Leu855Valfs∗4]; c.2564_2567dupTGTT [p.Leu856Phefs∗5]) are predicted to lead to a truncated cytoplasmic domain. Our study demonstrates that de novo heterozygous variants in CDH2 impair the adhesive activity of N-cadherin, resulting in a multisystemic developmental disorder, that could be named ACOG syndrome (agenesis of corpus callosum, axon pathfinding, cardiac, ocular, and genital defects).

Published
2019

35. Measurement of the cosmic ray proton spectrum from 40 GeV to 100 TeV with the DAMPE satellite.

Author

DAMPE Collaboration, An, Q, Asfandiyarov, R, Azzarello, P, Bernardini, P, Bi, XJ, Cai, MS, Chang, J, Chen, DY, Chen, HF, Chen, JL, Chen, W, Cui, MY, Cui, TS, Dai, HT, D'Amone, A, De Benedittis, A, De Mitri, I, Di Santo, M, Ding, M, Dong, TK, Dong, YF, Dong, ZX, Donvito, G, Droz, D, Duan, JL, Duan, KK, D'Urso, D, Fan, RR, Fan, YZ, Fang, F, Feng, CQ, Feng, L, Fusco, P, Gallo, V, Gan, FJ, Gao, M, Gargano, F, Gong, K, Gong, YZ, Guo, DY, Guo, JH, Guo, XL, Han, SX, Hu, YM, Huang, GS, Huang, XY, Huang, YY, Ionica, M, Jiang, W, Jin, X, Kong, J, Lei, SJ, Li, S, Li, WL, Li, X, Li, XQ, Li, Y, Liang, YF, Liang, YM, Liao, NH, Liu, CM, Liu, H, Liu, J, Liu, SB, Liu, WQ, Liu, Y, Loparco, F, Luo, CN, Ma, M, Ma, PX, Ma, SY, Ma, T, Ma, XY, Marsella, G, Mazziotta, MN, Mo, D, Niu, XY, Pan, X, Peng, WX, Peng, XY, Qiao, R, Rao, JN, Salinas, MM, Shang, GZ, Shen, WH, Shen, ZQ, Shen, ZT, Song, JX, Su, H, Su, M, Sun, ZY, Surdo, A, Teng, XJ, Tykhonov, A, Vitillo, S, Wang, C, Wang, H, Wang, HY, and Wang, JZ

Subjects
DAMPE Collaboration, astro-ph.HE
Abstract

The precise measurement of the spectrum of protons, the most abundant component of the cosmic radiation, is necessary to understand the source and acceleration of cosmic rays in the Milky Way. This work reports the measurement of the cosmic ray proton fluxes with kinetic energies from 40 GeV to 100 TeV, with 2 1/2 years of data recorded by the DArk Matter Particle Explorer (DAMPE). This is the first time that an experiment directly measures the cosmic ray protons up to ~100 TeV with high statistics. The measured spectrum confirms the spectral hardening at ~300 GeV found by previous experiments and reveals a softening at ~13.6 TeV, with the spectral index changing from ~2.60 to ~2.85. Our result suggests the existence of a new spectral feature of cosmic rays at energies lower than the so-called knee and sheds new light on the origin of Galactic cosmic rays.

Published
2019

36. Measurement of the cosmic ray proton spectrum from 40 GeV to 100 TeV with the DAMPE satellite

Author

Collaboration, DAMPE, An, Q, Asfandiyarov, R, Azzarello, P, Bernardini, P, Bi, XJ, Cai, MS, Chang, J, Chen, DY, Chen, HF, Chen, JL, Chen, W, Cui, MY, Cui, TS, Dai, HT, D’Amone, A, De Benedittis, A, De Mitri, I, Di Santo, M, Ding, M, Dong, TK, Dong, YF, Dong, ZX, Donvito, G, Droz, D, Duan, JL, Duan, KK, D’Urso, D, Fan, RR, Fan, YZ, Fang, F, Feng, CQ, Feng, L, Fusco, P, Gallo, V, Gan, FJ, Gao, M, Gargano, F, Gong, K, Gong, YZ, Guo, DY, Guo, JH, Guo, XL, Han, SX, Hu, YM, Huang, GS, Huang, XY, Huang, YY, Ionica, M, Jiang, W, Jin, X, Kong, J, Lei, SJ, Li, S, Li, WL, Li, X, Li, XQ, Li, Y, Liang, YF, Liang, YM, Liao, NH, Liu, CM, Liu, H, Liu, J, Liu, SB, Liu, WQ, Liu, Y, Loparco, F, Luo, CN, Ma, M, X., P, Y., S, Ma, T, Y., X, Marsella, G, Mazziotta, MN, Mo, D, Niu, XY, Pan, X, Peng, WX, Peng, XY, Qiao, R, Rao, JN, Salinas, MM, Shang, GZ, Shen, WH, Shen, ZQ, Shen, ZT, Song, JX, Su, H, Su, M, Sun, ZY, Surdo, A, Teng, XJ, Tykhonov, A, Vitillo, S, Wang, C, Wang, H, Wang, HY, and Wang, JZ

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, DAMPE Collaboration, astro-ph.HE
Abstract

The precise measurement of the spectrum of protons, the most abundant component of the cosmic radiation, is necessary to understand the source and acceleration of cosmic rays in the Milky Way. This work reports the measurement of the cosmic ray proton fluxes with kinetic energies from 40 GeV to 100 TeV, with 2 1/2 years of data recorded by the DArk Matter Particle Explorer (DAMPE). This is the first time that an experiment directly measures the cosmic ray protons up to ~100 TeV with high statistics. The measured spectrum confirms the spectral hardening at ~300 GeV found by previous experiments and reveals a softening at ~13.6 TeV, with the spectral index changing from ~2.60 to ~2.85. Our result suggests the existence of a new spectral feature of cosmic rays at energies lower than the so-called knee and sheds new light on the origin of Galactic cosmic rays.

Published
2019

37. Heterozygous Variants in KMT2E Cause a Spectrum of Neurodevelopmental Disorders and Epilepsy

Author

O’Donnell-Luria, Anne H, Pais, Lynn S, Faundes, Víctor, Wood, Jordan C, Sveden, Abigail, Luria, Victor, Jamra, Rami Abou, Accogli, Andrea, Amburgey, Kimberly, Anderlid, Britt Marie, Azzarello-Burri, Silvia, Basinger, Alice A, Bianchini, Claudia, Bird, Lynne M, Buchert, Rebecca, Carre, Wilfrid, Ceulemans, Sophia, Charles, Perrine, Cox, Helen, Culliton, Lisa, Currò, Aurora, Study, Deciphering Developmental Disorders, McRae, Jeremy F, Clayton, Stephen, Fitzgerald, Tomas W, Kaplanis, Joanna, Prigmore, Elena, Rajan, Diana, Sifrim, Alejandro, Aitken, Stuart, Akawi, Nadia, Alvi, Mohsan, Ambridge, Kirsty, Barrett, Daniel M, Bayzetinova, Tanya, Jones, Philip, Jones, Wendy D, King, Daniel, Krishnappa, Netravathi, Mason, Laura E, Singh, Tarjinder, Tivey, Adrian R, Ahmed, Munaza, Anjum, Uruj, Archer, Hayley, Armstrong, Ruth, Awada, Jana, Balasubramanian, Meena, Banka, Siddharth, Baralle, Diana, Barnicoat, Angela, Batstone, Paul, Baty, David, Bennett, Chris, Berg, Jonathan, Bernhard, Birgitta, Bevan, A Paul, Bitner-Glindzicz, Maria, Blair, Edward, Blyth, Moira, Bohanna, David, Bourdon, Louise, Bourn, David, Bradley, Lisa, Brady, Angela, Brent, Simon, Brewer, Carole, Brunstrom, Kate, Bunyan, David J, Burn, John, Canham, Natalie, Castle, Bruce, Chandler, Kate, Chatzimichali, Elena, Cilliers, Deirdre, Clarke, Angus, Clasper, Susan, Clayton-Smith, Jill, Clowes, Virginia, Coates, Andrea, Cole, Trevor, Colgiu, Irina, Collins, Amanda, Collinson, Morag N, Connell, Fiona, Cooper, Nicola, Cresswell, Lara, Cross, Gareth, Crow, Yanick, D’Alessandro, Mariella, Dabir, Tabib, Davidson, Rosemarie, Davies, Sally, de Vries, Dylan, Dean, John, Deshpande, Charu, Devlin, Gemma, Dixit, Abhijit, and Dobbie, Angus

Subjects
Biological Sciences, Genetics, Autism, Neurosciences, Brain Disorders, Neurodegenerative, Intellectual and Developmental Disabilities (IDD), Pediatric, Clinical Research, Epilepsy, Mental Health, Aetiology, 2.1 Biological and endogenous factors, Neurological, Adolescent, Adult, Child, Child, Preschool, DNA-Binding Proteins, Female, Genetic Variation, Haploinsufficiency, Heterozygote, Humans, Infant, Male, Neurodevelopmental Disorders, Pedigree, Phenotype, Young Adult, Deciphering Developmental Disorders (DDD) Study, H3K4 methylation, KMT2E, autism, epilepsy, epileptic encephalopathy, global developmental delay, intellectual disability, neurodevelopmental disorder, Medical and Health Sciences, Genetics & Heredity, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

We delineate a KMT2E-related neurodevelopmental disorder on the basis of 38 individuals in 36 families. This study includes 31 distinct heterozygous variants in KMT2E (28 ascertained from Matchmaker Exchange and three previously reported), and four individuals with chromosome 7q22.2-22.23 microdeletions encompassing KMT2E (one previously reported). Almost all variants occurred de novo, and most were truncating. Most affected individuals with protein-truncating variants presented with mild intellectual disability. One-quarter of individuals met criteria for autism. Additional common features include macrocephaly, hypotonia, functional gastrointestinal abnormalities, and a subtle facial gestalt. Epilepsy was present in about one-fifth of individuals with truncating variants and was responsive to treatment with anti-epileptic medications in almost all. More than 70% of the individuals were male, and expressivity was variable by sex; epilepsy was more common in females and autism more common in males. The four individuals with microdeletions encompassing KMT2E generally presented similarly to those with truncating variants, but the degree of developmental delay was greater. The group of four individuals with missense variants in KMT2E presented with the most severe developmental delays. Epilepsy was present in all individuals with missense variants, often manifesting as treatment-resistant infantile epileptic encephalopathy. Microcephaly was also common in this group. Haploinsufficiency versus gain-of-function or dominant-negative effects specific to these missense variants in KMT2E might explain this divergence in phenotype, but requires independent validation. Disruptive variants in KMT2E are an under-recognized cause of neurodevelopmental abnormalities.

Published
2019

39. Internal alignment and position resolution of the silicon tracker of DAMPE determined with orbit data

Author

Tykhonov, A., Ambrosi, G., Asfandiyarov, R., Azzarello, P., Bernardini, P., Bertucci, B., Bolognini, A., Cadoux, F., D'Amone, A., De Benedittis, A., De Mitri, I., Di Santo, M., Dong, Y. F., Duranti, M., D'Urso, D., Fan, R. R., Fusco, P., Gallo, V., Gao, M., Gargano, F., Garrappa, S., Gong, K., Ionica, M., La Marra, D., Lei, S. J., Li, X., Loparco, F., Marsella, G., Mazziotta, M. N., Peng, W. X., Qiao, R., Salinas, M. M., Surdo, A., Vagelli, V., Vitillo, S., Wang, H. Y., Wang, J. Z., Wu, D., Wu, X., Zhang, F., Zhang, J. Y., Zhao, H., and Zimmer, S.

Subjects
Physics - Instrumentation and Detectors
Abstract

The DArk Matter Particle Explorer (DAMPE) is a space-borne particle detector designed to probe electrons and gamma-rays in the few GeV to 10 TeV energy range, as well as cosmic-ray proton and nuclei components between 10 GeV and 100 TeV. The silicon-tungsten tracker-converter is a crucial component of DAMPE. It allows the direction of incoming photons converting into electron-positron pairs to be estimated, and the trajectory and charge (Z) of cosmic-ray particles to be identified. It consists of 768 silicon micro-strip sensors assembled in 6 double layers with a total active area of 6.6 m$^2$. Silicon planes are interleaved with three layers of tungsten plates, resulting in about one radiation length of material in the tracker. Internal alignment parameters of the tracker have been determined on orbit, with non-showering protons and helium nuclei. We describe the alignment procedure and present the position resolution and alignment stability measurements.

Published
2017
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40. Direct detection of a break in the teraelectronvolt cosmic-ray spectrum of electrons and positrons

Author

Ambrosi, G., An, Q., Asfandiyarov, R., Azzarello, P., Bernardini, P., Bertucci, B., Cai, M. S., Chang, J., Chen, D. Y., Chen, H. F., Chen, J. L., Chen, W., Cui, M. Y., Cui, T. S., D'Amone, A., De Benedittis, A., De Mitri, I., Di Santo, M., Dong, J. N., Dong, T. K., Dong, Y. F., Dong, Z. X., Donvito, G., Droz, D., Duan, K. K., Duan, J. L., Duranti, M., D'Urso, D., Fan, R. R., Fan, Y. Z., Fang, F., Feng, C. Q., Feng, L., Fusco, P., Gallo, V., Gan, F. J., Gao, M., Gao, S. S., Gargano, F., Garrappa, S., Gong, K., Gong, Y. Z., Guo, D. Y., Guo, J. H., Hu, Y. M., Huang, G. S., Huang, Y. Y., Ionica, M., Jiang, D., Jiang, W., Jin, X., Kong, J., Lei, S. J., Li, S., Li, X., Li, W. L., Li, Y., Liang, Y. F., Liang, Y. M., Liao, N. H., Liu, H., Liu, J., Liu, S. B., Liu, W. Q., Liu, Y., Loparco, F., Ma, M., Ma, P. X., Ma, S. Y., Ma, T., Ma, X. Q., Ma, X. Y., Marsella, G., Mazziotta, M. N., Mo, D., Niu, X. Y., Peng, X. Y., Peng, W. X., Qiao, R., Rao, J. N., Salinas, M. M., Shang, G. Z., Shen, W. H., Shen, Z. Q., Shen, Z. T., Song, J. X., Su, H., Su, M., Sun, Z. Y., Surdo, A., Teng, X. J., Tian, X. B., Tykhonov, A., Vagelli, V., Vitillo, S., Wang, C., Wang, H., Wang, H. Y., Wang, J. Z., Wang, L. G., Wang, Q., Wang, S., Wang, X. H., Wang, X. L., Wang, Y. F., Wang, Y. P., Wang, Y. Z., Wen, S. C., Wang, Z. M., Wei, D. M., Wei, J. J., Wei, Y. F., Wu, D., Wu, J., Wu, L. B., Wu, S. S., Wu, X., Xi, K., Xia, Z. Q., Xin, Y. L., Xu, H. T., Xu, Z. L., Xu, Z. Z., Xue, G. F., Yang, H. B., Yang, P., Yang, Y. Q., Yang, Z. L., Yao, H. J., Yu, Y. H., Yuan, Q., Yue, C., Zang, J. J., Zhang, C., Zhang, D. L., Zhang, F., Zhang, J. B., Zhang, J. Y., Zhang, J. Z., Zhang, L., Zhang, P. F., Zhang, S. X., Zhang, W. Z., Zhang, Y., Zhang, Y. J., Zhang, Y. Q., Zhang, Y. L., Zhang, Y. P., Zhang, Z., Zhang, Z. Y., Zhao, H., Zhao, H. Y., Zhao, X. F., Zhou, C. Y., Zhou, Y., Zhu, X., Zhu, Y., and Zimmer, S.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

High energy cosmic ray electrons plus positrons (CREs), which lose energy quickly during their propagation, provide an ideal probe of Galactic high-energy processes and may enable the observation of phenomena such as dark-matter particle annihilation or decay. The CRE spectrum has been directly measured up to $\sim 2$ TeV in previous balloon- or space-borne experiments, and indirectly up to $\sim 5$ TeV by ground-based Cherenkov $\gamma$-ray telescope arrays. Evidence for a spectral break in the TeV energy range has been provided by indirect measurements of H.E.S.S., although the results were qualified by sizeable systematic uncertainties. Here we report a direct measurement of CREs in the energy range $25~{\rm GeV}-4.6~{\rm TeV}$ by the DArk Matter Particle Explorer (DAMPE) with unprecedentedly high energy resolution and low background. The majority of the spectrum can be properly fitted by a smoothly broken power-law model rather than a single power-law model. The direct detection of a spectral break at $E \sim0.9$ TeV confirms the evidence found by H.E.S.S., clarifies the behavior of the CRE spectrum at energies above 1 TeV and sheds light on the physical origin of the sub-TeV CREs., Comment: 18 pages, 6 figures, Nature in press, doi:10.1038/nature24475

Published
2017
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41. The DArk Matter Particle Explorer mission

Author

Chang, J., Ambrosi, G., An, Q., Asfandiyarov, R., Azzarello, P., Bernardini, P., Bertucci, B., Cai, M. S., Caragiulo, M., Chen, D. Y., Chen, H. F., Chen, J. L., Chen, W., Cui, M. Y., Cui, T. S., D'Amone, A., De Benedittis, A., De Mitri, I., Di Santo, M., Dong, J. N., Dong, T. K., Dong, Y. F., Dong, Z. X., Donvito, G., Droz, D., Duan, K. K., Duan, J. L., Duranti, M., D'Urso, D., Fan, R. R., Fan, Y. Z., Fang, F., Feng, C. Q., Feng, L., Fusco, P., Gallo, V., Gan, F. J., Gan, W. Q., Gao, M., Gao, S. S., Gargano, F., Gong, K., Gong, Y. Z., Guo, J. H., Hu, Y. M., Huang, G. S., Huang, Y. Y., Ionica, M., Jiang, D., Jiang, W., Jin, X., Kong, J., Lei, S. J., Li, S., Li, X., Li, W. L., Li, Y., Liang, Y. F., Liang, Y. M., Liao, N. H., Liu, Q. Z., Liu, H., Liu, J., Liu, S. B., Liu, W. Q., Liu, Y., Loparco, F., Lü, J., Ma, M., Ma, P. X., Ma, S. Y., Ma, T., Ma, X. Q., Ma, X. Y., Marsella, G., Mazziotta, M. N., Mo, D., Miao, T. T., Niu, X. Y., Pohl, M., Peng, X. Y., Peng, W. X., Qiao, R., Rao, J. N., Salinas, M. M., Shang, G. Z., Shen, W. H., Shen, Z. Q., Shen, Z. T., Song, J. X., Su, H., Su, M., Sun, Z. Y., Surdo, A., Teng, X. J., Tian, X. B., Tykhonov, A., Vagelli, V., Vitillo, S., Wang, C., Wang, Chi, Wang, H., Wang, H. Y., Wang, J. Z., Wang, L. G., Wang, Q., Wang, S., Wang, X. H., Wang, X. L., Wang, Y. F., Wang, Y. P., Wang, Y. Z., Wen, S. C., Wang, Z. M., Wei, D. M., Wei, J. J., Wei, Y. F., Wu, D., Wu, J., Wu, S. S., Wu, X., Xi, K., Xia, Z. Q., Xin, Y. L., Xu, H. T., Xu, Z. L., Xu, Z. Z., Xue, G. F., Yang, H. B., Yang, J., Yang, P., Yang, Y. Q., Yang, Z. L., Yao, H. J., Yu, Y. H., Yuan, Q., Yue, C., Zang, J. J., Zhang, C., Zhang, D. L., Zhang, F., Zhang, J. B., Zhang, J. Y., Zhang, J. Z., Zhang, L., Zhang, P. F., Zhang, S. X., Zhang, W. Z., Zhang, Y., Zhang, Y. J., Zhang, Y. Q., Zhang, Y. L., Zhang, Y. P., Zhang, Z., Zhang, Z. Y., Zhao, H., Zhao, H. Y., Zhao, X. F., Zhou, C. Y., Zhou, Y., Zhu, X., Zhu, Y., and Zimmer, S.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The DArk Matter Particle Explorer (DAMPE), one of the four scientific space science missions within the framework of the Strategic Pioneer Program on Space Science of the Chinese Academy of Sciences, is a general purpose high energy cosmic-ray and gamma-ray observatory, which was successfully launched on December 17th, 2015 from the Jiuquan Satellite Launch Center. The DAMPE scientific objectives include the study of galactic cosmic rays up to $\sim 10$ TeV and hundreds of TeV for electrons/gammas and nuclei respectively, and the search for dark matter signatures in their spectra. In this paper we illustrate the layout of the DAMPE instrument, and discuss the results of beam tests and calibrations performed on ground. Finally we present the expected performance in space and give an overview of the mission key scientific goals., Comment: 45 pages, including 29 figures and 6 tables. Published in Astropart. Phys

Published
2017
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42. Charge reconstruction study of the DAMPE Silicon-Tungsten Tracker with ion beams

Author

Qiao, Rui, Peng, Wen-Xi, Guo, Dong-Ya, Zhao, Hao, Wang, Huan-Yu, Gong, Ke, Zhang, Fei, Wu, Xin, Azzarello, Phillip, Tykhonov, Andrii, Asfandiyarov, Ruslan, Gallo, Valentina, Ambrosi, Giovanni, Mazziotta, Nicola, and De Mitri, Ivan

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The DArk Matter Particle Explorer (DAMPE) is one of the four satellites within Strategic Pioneer Research Program in Space Science of the Chinese Academy of Science (CAS). DAMPE can detect electrons, photons in a wide energy range (5 GeV to 10 TeV) and ions up to iron (100GeV to 100 TeV). Silicon-Tungsten Tracker (STK) is one of the four subdetectors in DAMPE, providing photon-electron conversion, track reconstruction and charge identification for ions. Ion beam test was carried out in CERN with 60GeV/u Lead primary beams. Charge reconstruction and charge resolution of STK detectors were investigated., Comment: 7 pages, 8 figures

Published
2017
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43. A Tool for Narrowing the Second Chance Gap

Author

Shaghaghi, Navid, Huang, Zuyan, Bathala, Hithesh Sekhar, Azzarello, Connor, Chen, Anthony, Chien, Colleen V., Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin (Sherman), Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Shaghaghi, Navid, editor, Lamberti, Fabrizio, editor, Beams, Brian, editor, Shariatmadari, Reza, editor, and Amer, Ahmed, editor

Published
2021
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44. The Impact of Amplification on Cognitive Screening Test Scores

Author

Gaeta, Laura, Azzarello, Jo, Baldwin, Jonathan, Ciro, Carrie, Hudson, Mary A., Johnson, Carole E., and John, Andrew B.

Subjects
Cognition -- Testing, Aged -- Health aspects -- Medical examination, Medical screening -- Methods, Health, Seniors
Abstract

Hearing loss is associated with cognitive decline in older adults. Research has shown that hearing loss negatively affects cognitive screening test measures as patients may mishear verbally administered questions. The purpose of the current study was to investigate the impact of amplification on performance on a commonly used cognitive screening test. Thirty older adults with hearing loss underwent testing with the Mini-Mental State Examination (MMSE) in three conditions: without hearing aids, with hearing aids, and with a personal listening device (PLD). Performance on the MMSE significantly improved with the use of hearing aids or a PLD. Amplification and the use of communication strategies should be considered when administering cognitive screening measures to older adults. Failure to account for hearing status may lead to invalid results and can increase the likelihood of over-referral for further assessment. [Journal of Gerontological Nursing, 48(7), 31–37.], Presbycusis refers to sensorineural hearing loss (SNHL) that is due to pathophysiological changes throughout the auditory system accompanying aging. Presbycusis is associated with a gradual loss of hearing sensitivity and [...]

Published
2022
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50. Design of the readout electronics for the DAMPE Silicon Tracker detector

Author

Zhang, Fei, Peng, Wen-Xi, Gong, Ke, Wu, Di, Dong, Yi-Fan, Qiao, Rui, Fan, Rui-Rui, Wang, Jin-Zhou, Wang, Huan-Yu, Wu, Xin, La Marra, Daniel, Azzarello, Philipp, Gallo, Valentina, Ambrosi, Giovanni, and Nardinocchi, Andrea

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The Silicon Tracker (STK) is a detector of the DAMPE satellite to measure the incidence direction of high energy cosmic ray. It consists of 6 X-Y double layers of silicon micro-strip detectors with 73,728 readout channels. It's a great challenge to readout the channels and process the huge volume of data in the critical space environment. 1152 Application Specific Integrated Circuits (ASIC) and 384 ADCs are adopted to readout the detector channels. The 192 Tracker Front-end Hybrid (TFH) modules and 8 identical Tracker Readout Board (TRB) modules are designed to control and digitalize the front signals. In this paper, the design of the readout electronics for STK and its performance will be presented in detail., Comment: 10 pages, 17 figures

Published
2016
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