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34 results on '"Azmi, Nur Hanisah"'

11. Nutrigenomic Effects of White Rice and Brown Rice on the Pathogenesis of Metabolic Disorders in a Fruit Fly Model

Author

Saka, Saheed Olanrewaju, primary, Salisu, Yusuf Yahaya, additional, Sahabi, Hauwa’u Muhammad, additional, Sanusi, Kamaldeen Olalekan, additional, Ibrahim, Kasimu Ghandi, additional, Abubakar, Murtala Bello, additional, Isa, Suleiman Ahmed, additional, Liman, Muhammad Gidado, additional, Shehu, Sha’aya’u, additional, Malami, Ibrahim, additional, Chan, Kim Wei, additional, Azmi, Nur Hanisah, additional, and Imam, Mustapha Umar, additional

Published
2023
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17. Germinated brown rice regulates brain oxidative stress, inflammation and acetylcholinesterase level: implication in neurodegenerative diseases

Author

Mohammed Alitheen Noorjahan Banu, Ismail Norsharina, Ismail Maznah, Abdullah Maizaton Atmadini, and Azmi Nur Hanisah

Subjects
Cellular and Molecular Neuroscience, chemistry.chemical_compound, chemistry, Biochemistry, Germination, medicine, Brown rice, Inflammation, Biology, medicine.symptom, medicine.disease_cause, Acetylcholinesterase, Oxidative stress
Published
2016

18. Beneficial effects of TQRF and TQ nano- and conventional emulsions on memory deficit, lipid peroxidation, total antioxidant status, antioxidants genes expression and soluble Aβ levels in high fat-cholesterol diet-induced rats

Author

Ismail, Norsharina, primary, Ismail, Maznah, additional, Azmi, Nur Hanisah, additional, Bakar, Muhammad Firdaus Abu, additional, Yida, Zhang, additional, Stanslas, Johnson, additional, Sani, Dahiru, additional, Basri, Hamidon, additional, and Abdullah, Maizaton Atmadini, additional

Published
2017
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19. Are bioactive-rich fractions functionally richer?

Author

Imam, Mustapha Umar, Ismail, Maznah, Der, Jiun Ooi, Azmi, Nur Hanisah, Sarega, Nadarajan, Kim, Wei Chan, Bhanger, Muhammad Iqbal, Imam, Mustapha Umar, Ismail, Maznah, Der, Jiun Ooi, Azmi, Nur Hanisah, Sarega, Nadarajan, Kim, Wei Chan, and Bhanger, Muhammad Iqbal

Abstract

Plant bioresources are relied upon as natural, inexpensive, and sustainable remedies for the management of several chronic diseases worldwide. Plants have historically been consumed for medicinal purposes based on traditional belief, but this trend is currently changing. The growing interest in the medicinal properties of plant bioresources stems from concerns of side effects and other adverse effects caused by synthetic drugs. This interest has yielded a better understanding of the roles of plant bioactive compounds in health promotion and disease prevention, including the underlying mechanisms involved in such functional effects. The desire to maximize the potential of phytochemicals has led to the development of "rich fractions," in which extracts contain bioactive compounds in addition to elevated levels of the primary compound. Although a rich fraction effectively increases the bioactivity of the extract, the standardization and quality assurance process can be challenging. However, the supercritical fluid extraction (SFE) system is a promising green technology in this regard. Future clinical and pharmacological studies are needed to fully elucidate the implications of these preparations in the management of human diseases, thereby fostering a move toward evidence-based medicine.

Published
2016

21. Antidiabetic Properties of Germinated Brown Rice: A Systematic Review

Author

Imam, Mustapha Umar, Azmi, Nur Hanisah, Bhanger, Muhammad Iqbal, Ismail, Norsharina, and Ismail, Maznah

Subjects
Article Subject
Abstract

Diet is an important variable in the course of type 2 diabetes, which has generated interest in dietary options like germinated brown rice (GBR) for effective management of the disease among rice-consuming populations. In vitro data and animal experiments show that GBR has potentials as a functional diet for managing this disease, and short-term clinical studies indicate encouraging results. Mechanisms for antidiabetic effects of GBR due to bioactive compounds like γ-aminobutyric acid (GABA), γ-oryzanol, dietary fibre, phenolics, vitamins, acylated steryl β-glucoside, and minerals include antihyperglycemia, low insulin index, antioxidative effect, antithrombosis, antihypertensive effect, hypocholesterolemia, and neuroprotective effects. The evidence so far suggests that there may be enormous benefits for diabetics in rice-consuming populations if white rice is replaced with GBR. However, long-term clinical studies are still needed to verify these findings on antidiabetic effects of GBR. Thus, we present a review on the antidiabetic properties of GBR from relevant preclinical and clinical studies, in order to provide detailed information on this subject for researchers to review the potential of GBR in combating this disease.

Published
2012
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25. N-Acetylneuraminic Acid Supplementation Prevents High Fat Diet-Induced Insulin Resistance in Rats through Transcriptional and Nontranscriptional Mechanisms

Author

Yida, Zhang, primary, Imam, Mustapha Umar, additional, Ismail, Maznah, additional, Ismail, Norsharina, additional, Azmi, Nur Hanisah, additional, Wong, Waiteng, additional, Altine Adamu, Hadiza, additional, Md Zamri, Nur Diyana, additional, Ideris, Aini, additional, and Abdullah, Maizaton Atmadini, additional

Published
2015
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28. Ethyl acetate extract of germinated brown rice attenuates hydrogen peroxide-induced oxidative stress in human SH-SY5Y neuroblastoma cells: role of anti-apoptotic, pro-survival and antioxidant genes

Author

Azmi, Nur Hanisah, Ismail, Norsharina, Imam, Mustapha Umar, Ismail, Maznah, Azmi, Nur Hanisah, Ismail, Norsharina, Imam, Mustapha Umar, and Ismail, Maznah

Abstract

Background There are reports of improved metabolic outcomes due to consumption of germinated brown rice (GBR). Many of the functional effects of GBR can be linked to its high amounts of antioxidants. Interestingly, dietary components with high antioxidants have shown promise in the prevention of neurodegenerative diseases like Alzheimer’s disease (AD). This effect of dietary components is mostly based on their ability to prevent apoptosis, which is believed to link oxidative damage to pathological changes in AD. In view of the rich antioxidant content of GBR, we studied its potential to modulate processes leading up to AD. Methods The total phenolic content and antioxidant capacity of the ethyl acetate extract of GBR were compared to that of brown rice (BR), and the cytotoxicity of both extracts were determined on human SH-SY5Y neuronal cells using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) Assay. Based on its higher antioxidant potentials, the effect of the GBR extract on morphological changes due to hydrogen peroxide (H2O2)-induced oxidative damage in human SH-SY5Y neuronal cells was examined using inverted light microscope and fluorescence microscope by means of acridine orange-propidium iodide (AO/PI) staining. Also, evaluation of the transcriptional regulation of antioxidant and apoptotic genes was carried out using Multiplex Gene Expression System. Results The ethyl acetate extract of GBR had higher total phenolic content and antioxidant capacity compared to BR. The cytotoxicity results showed that GBR extract did not cause any damage to the human SH-SY5Y neuronal cells at concentrations of up to 20 ppm, and the morphological analyses showed that the GBR extract (up to 10 ppm) prevented H2O2-induced apoptotic changes in the cells. Furthermore, multiplex gene expression analyses showed that the protection of the cells by the GBR extract was linked to its ability to induce transcriptional changes in antioxidant (SOD 1, SOD 2 and catalase)

Published
2013

29. Curculigoside and polyphenol-rich ethyl acetate fraction of Molineria latifoliarhizome improved glucose uptake via potential mTOR/AKT activated GLUT4 translocation

Author

Ooi, Der Jiun, Azmi, Nur Hanisah, Imam, Mustapha Umar, Alitheen, Noorjahan Banu, and Ismail, Maznah

Abstract

Adipose tissue is one of the major organs responsible for rapid restoration of postprandial glucose fluxes. Being the major isoform of glucose transporter in adipose tissue, regulations of insulin-dependent GLUT4 trafficking have always been of research interest. The present study aimed to examine the molecular mechanisms underlying the efficacy of curculigoside and polyphenol-rich ethyl acetate fraction (EAF) of Molineria latifoliarhizome in triggering glucose uptake. We assessed the adipogenic potential and glucose uptake stimulatory activity of curculigoside and EAF by employing a murine 3T3-L1 adipocyte model. The transcriptional and translational expressions of selected intermediates in the insulin signalling pathway were evaluated. While curculigoside neither promoted adipogenesis nor activated peroxisome proliferator activated receptor gamma, treatment with polyphenol-rich EAF resulted otherwise. However, both treatments enhanced insulin-stimulated uptake of glucose. This was coupled with increased availability of GLUT4 at the plasma membrane of the differentiated adipocytes although the total GLUT4 protein level was unaffected. In addition, the treatment increased the phosphorylation of both AKT and mTOR, which have been reported to be associated with GLUT4 translocation. The present findings proposed that curculigoside and EAF increased glucose transport activity of 3T3-L1 adipocytes via GLUT4 translocation as a result of potential mTOR/AKT activation. The more potent efficacy observed with EAF suggested potential synergistic and multi-targeted action.

Published
2018
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33. Increased fucoxanthin in Chaetoceros calcitrans extract exacerbates apoptosis in liver cancer cells via multiple targeted cellular pathways.

Author

Foo SC, Yusoff FM, Imam MU, Foo JB, Ismail N, Azmi NH, Tor YS, Khong NMH, and Ismail M

Abstract

In this study, anti-proliferative effects of C. calcitrans extract and its fucoxanthin rich fraction (FxRF) were assessed on human liver HepG2 cancer cell line. Efficacy from each extract was determined by cytotoxicity assay, morphological observation, and cell cycle analysis. Mechanisms of action observed were evaluated using multiplex gene expression analysis. Results showed that CME and FxRF induced cytotoxicity to HepG2 cells in a dose and time-dependent manner. FxRF (IC 50 : 18.89 μg.mL -1 ) was found to be significantly more potent than CME (IC 50 : 87.5 μg.mL -1 ) (p < 0.05). Gene expression studies revealed that anti-proliferative effects in treated cells by C. calcitrans extracts were mediated partly through the modulation of numerous genes involved in cell signaling ( AKT1 , ERK1/2 , JNK ), apoptosis ( BAX, BID, Bcl-2, APAF, CYCS ) and oxidative stress ( SOD1 , SOD2 , CAT ). Overall, C. calcitrans extracts demonstrated effective intervention against HepG2 cancer cells where enhanced apoptotic activities were observed with increased fucoxanthin content.

Published
2018
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34. Are bioactive-rich fractions functionally richer?

Author

Imam MU, Ismail M, Ooi DJ, Azmi NH, Sarega N, Chan KW, and Bhanger MI

Subjects
Animals, Humans, Phytotherapy, Benzoquinones pharmacology, Phenylpropionates pharmacology, Plant Extracts pharmacology, Tocotrienols pharmacology
Abstract

Plant bioresources are relied upon as natural, inexpensive, and sustainable remedies for the management of several chronic diseases worldwide. Plants have historically been consumed for medicinal purposes based on traditional belief, but this trend is currently changing. The growing interest in the medicinal properties of plant bioresources stems from concerns of side effects and other adverse effects caused by synthetic drugs. This interest has yielded a better understanding of the roles of plant bioactive compounds in health promotion and disease prevention, including the underlying mechanisms involved in such functional effects. The desire to maximize the potential of phytochemicals has led to the development of "rich fractions," in which extracts contain bioactive compounds in addition to elevated levels of the primary compound. Although a rich fraction effectively increases the bioactivity of the extract, the standardization and quality assurance process can be challenging. However, the supercritical fluid extraction (SFE) system is a promising green technology in this regard. Future clinical and pharmacological studies are needed to fully elucidate the implications of these preparations in the management of human diseases, thereby fostering a move toward evidence-based medicine.

Published
2016
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