15 results on '"Azevedo MCVM"'
Search Results
2. COVID-19 cross-sectional study in Maricá, Brazil: The impact of vaccination coverage on viral incidence.
- Author
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Frauches TS, Costa CAS, Rodrigues CDS, de Azevedo MCVM, Ferreira MM, Ramos HBVDS, de Souza Junior WR, Costa AR, Camargo AC, Alonso AH, Dos Santos FÁ, Oliveira HDS, Coelho JG, Sobral JFDS, Rodrigues LCDS, Ferreira MMC, Laureano P, da Paz Fernandes RA, Santos RDS, Dos Santos RMC, Milagres S, Dos Santos VCC, Silva JT, da Silva TM, da Rocha MGC, de São Carlos AE, de Araújo Ramos AM, Bastos FMA, Francisco DR, Rosa SDS, Linhares LC, Organista RR, Bastos L, Pinto MMK, do Nascimento JPL, da Silveira JPM, Dos Santos MQ, da Silva NS, Ferreira NCDS, Reis RBR, de Oliveira RF, Sá VO, Hammes TRS, Monteiro JO, Cardoso PH, Arruda MB, Alvarez P, Maia RA, Ribeiro LJ, Ferreira OC Jr, Santos A, de Almeida ACM, Garcia L, Pansera C, and Tanuri A
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- Antibodies, Neutralizing, Antibodies, Viral, Brazil epidemiology, Cross-Sectional Studies, Humans, Immunoglobulin G, Incidence, Pandemics, SARS-CoV-2, COVID-19 epidemiology, COVID-19 prevention & control, Vaccination Coverage
- Abstract
Population surveillance in COVID-19 Pandemic is crucial to follow up the pace of disease and its related immunological status. Here we present a cross-sectional study done in Maricá, a seaside town close to the city of Rio de Janeiro, Brazil. Three rounds of study sampling, enrolling a total of 1134 subjects, were performed during May to August 2021. Here we show that the number of individuals carrying detectable IgG antibodies and the neutralizing antibody (NAb) levels were greater in vaccinated groups compared to unvaccinated ones, highlighting the importance of vaccination to attain noticeable levels of populational immunity against SARS-CoV-2. Moreover, we found a decreased incidence of COVID-19 throughout the study, clearly correlated with the level of vaccinated individuals as well as the proportion of individuals with detectable levels of IgG anti-SARS-CoV-2 and NAb. The observed drop occurred even during the introduction of the Delta variant in Maricá, what suggests that the vaccination slowed down the widespread transmission of this variant. Overall, our data clearly support the use of vaccines to drop the incidence associated to SARS-CoV-2., Competing Interests: The authors have declared that no competing interests exist.
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- 2022
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3. Polymorphisms at CYP enzymes, NR1I2 and NR1I3 in association with virologic response to antiretroviral therapy in Brazilian HIV-positive individuals.
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de Almeida Velozo C, de Almeida TB, de Azevedo MCVM, Espasandin I, da Cunha Pinto JF, López S, Pizzatti L, Tanuri A, da Silva Santos S, Ribeiro-Alves M, and Cardoso CC
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- Adult, Antiretroviral Therapy, Highly Active, Brazil, Cohort Studies, Cytochrome P-450 CYP2D6 genetics, Cytochrome P-450 CYP3A genetics, Female, HIV Infections drug therapy, Haplotypes, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Receptors, N-Methyl-D-Aspartate, Treatment Outcome, Anti-HIV Agents therapeutic use, Constitutive Androstane Receptor genetics, Cytochrome P-450 Enzyme System genetics, HIV Infections genetics, HIV Infections virology, HIV Seropositivity drug therapy, HIV Seropositivity genetics, Pregnane X Receptor genetics
- Abstract
Virologic failure of antiretroviral therapy (ART) may be explained by single nucleotide polymorphisms (SNPs) in drug absorption and metabolism genes. Here, we characterized the associations between polymorphisms in cytochrome P450 enzymes' genes CYP2B6 and CYP3A4/A5, nuclear receptor genes NR1I2/3, and initial ART efficacy among 203 HIV-positive individuals from Rio de Janeiro. Association between SNPs and virologic control was evaluated after 6 and 12 months of follow-up using Cox regression models. The SNP rs2307424 (NR1I3) was associated with increased virologic response after 12 months of treatment, while rs1523127 (NR1I2), rs3003596, and rs2502815 (NR1I3) were associated with decreased response. Increased virologic response after 12 months (
adj HR = 1.54; p = 0.02) was also observed among carriers of the NR1I3 haplotype rs2502815G-rs3003596A-rs2307424A versus the reference haplotype G-A-G. Our results suggest that NR1I2 and NR1I3 variants are associated with virologic responses to ART among Brazilians., (© 2021. The Author(s), under exclusive licence to Springer Nature Limited.)- Published
- 2022
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4. Development and validation of a simple and rapid way to generate low volume of plasma to be used in point-of-care HIV virus load technologies.
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Vasconcellos I, Mariani D, Azevedo MCVM, Ferreira OC Jr, and Tanuri A
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- Feasibility Studies, HIV Infections blood, HIV Infections virology, Humans, Linear Models, Reproducibility of Results, HIV isolation & purification, Plasma virology, Point-of-Care Systems, Viral Load methods
- Abstract
A new point-of-care HIV viral load, mPIMA HIV-1/2 VL, Abbott, USA, has been recently developed. This point-of-care viral load requires no skilled person to run and uses a small plasma volume (50μL). However, obtaining 50μL of plasma can be a challenge in limited resource settings. We validated a simple and easy method to obtain enough amount of plasma to run a point-of-care viral load. The study utilized 149 specimens from patients failing antiretroviral therapy. At least 250μL of whole blood was collected in a microtube/EDTA from fingerstick (fs-plasma) and immediately centrifuged. Parallel collection of venous blood to obtain plasma (vp-plasma) was used to compare performance in a point-of-care viral load assay and in methodology used in centralized laboratories Abbott M2000, Abbott, USA. The procedure for plasma collection takes less than 10min and in 94% of the cases only one fingerstick was sufficient to collect at least 250μL of blood. The Pearson correlation coefficient value for vp-plasma versus fs-plasma ran on mPIMA was 0.990. The Bland-Altman mean difference (md) for this comparison were virtually zero (md=-0.001) with limits of agreement between -0.225 and 0.223. In addition, the Pearson correlation coefficient value for fs-plasma in mPIMA versus vp-plasma in Abbott M2000 was 0.948 for values above the mPIMA limit of quantification (LoQ; from 800 to 1,000,000copies/mL). These results validate this simple plasma isolation method capable to be implemented in low resource countries where point-of-care decentralization is deeply needed., (Copyright © 2019 Sociedade Brasileira de Infectologia. Published by Elsevier España, S.L.U. All rights reserved.)
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- 2020
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5. The performance of a new point-of-care HIV virus load technology to identify patients failing antiretroviral treatment.
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Mariani D, de Azevedo MCVM, Vasconcellos I, Ribeiro L, Alves C, Ferreira OC Jr, and Tanuri A
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- Anti-HIV Agents therapeutic use, Germany, HIV Infections blood, HIV Infections drug therapy, HIV-1 isolation & purification, HIV-2 isolation & purification, Humans, Real-Time Polymerase Chain Reaction methods, Sensitivity and Specificity, HIV Infections diagnosis, Point-of-Care Systems standards, RNA, Viral blood, Viral Load instrumentation, Viral Load methods
- Abstract
Background: A new point-of-care (POC) HIV virus load technology has been recently developed and designed to be utilized in decentralized settings. Alere Technologies GmbH*, Germany, developed the mPIMA HIV-1/2 VL plasma test which uses real time PCR technology with 50 μl and a turnaround time of one hour., Objective: Analyze the performance of mPIMA to detect and quantify HIV-1 and HIV-2 and compare with Abbott M2000 assay fooling patients HIV-1 failing ARV therapy., Study Design: In this study we evaluate the mPIMA HIV-1/2 VL plasma test using 413 specimens from 270 patients failing ARV therapy, and compared its performance with Abbott RealTime HIV-1 Viral Load assay on the m2000 system. In addition, were determined VL in plasma specimens obtained from HIV-2 infected patients., Results: The results strongly indicate that mPIMA HIV-1/2 VL plasma test can determine HIV-1 with concordance of 88.9 % (95 % CI 85.4-91.7) the reference test when 1000 HIV-1 VL threshold was used as WHO cutoff to identify therapy failure. The overall correlation between HIV-1 VL was 0928 (Pearson correlation coefficient of Linear regression) and the Bland-Altman showed a mean difference of -0.20 Log cp/mL between the two technology. mPIMA HIV-1/2 VL plasma test was also able to measure HIV-2 viral load in 16 specimens from Guinea-Bissau HIV-1/HIV-2 positive samples., Conclusions: These data support the use of mPIMA HIV-1/2 VL plasma test to follow up patients and select patients failing ART, guiding immediate clinical decisions such as adherence counseling or ART regimen switch during the patient consultation., (Copyright © 2019 Elsevier B.V. All rights reserved.)
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- 2020
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6. Antiretroviral therapy-induced paradoxical worsening of previously healed Mycobacterium haemophilum cutaneous lesions in advanced HIV infection.
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Eyer-Silva WA, Almeida MR, Martins CJ, Basílio-de-Oliveira RP, Araujo LF, Basílio-de-Oliveira CA, Azevedo MCVM, Pinto JFDC, Vasconcellos SEG, Rodrigues-Dos-Santos Í, MagdinierGomes H, and Suffys PN
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- AIDS-Related Opportunistic Infections immunology, Adult, Anti-Retroviral Agents therapeutic use, CD4 Lymphocyte Count, Female, Humans, Immune Reconstitution Inflammatory Syndrome immunology, Immune Reconstitution Inflammatory Syndrome metabolism, Immunocompromised Host, Male, Mycobacterium Infections immunology, AIDS-Related Opportunistic Infections microbiology, Anti-Retroviral Agents adverse effects, Immune Reconstitution Inflammatory Syndrome microbiology, Mycobacterium Infections microbiology, Mycobacterium haemophilum isolation & purification
- Abstract
Mycobacterium haemophilum is a nontuberculous mycobacterium that causes localized or disseminated disease, mainly in immunocompromised hosts. We report the case of a 35-year-old HIV-infected woman who presented with several enlarging cutaneous lesions over the arms and legs. Histopathological examination revealed the diagnosis of a cutaneous mycobacterial disease. Mycobacterial analyses unveiled M. haemophilum infection. Six months after completion of a successful antimycobacterial treatment, she developed an immune reconstitution inflammatory syndrome (IRIS). This paradoxical relapse presented as tenderness, redness and swelling at the precise sites of the healed lesions and took place in the setting of significant recovery of the CD4 cell count (from 05 to 318 cells/mm 3 ). Microbiological analyses of these worsening lesions were negative, and they spontaneously remitted without the initiation of a novel antimycobacterial treatment cycle. M. haemophilum infection should always be considered as a cause of skin lesions in immunocompromised subjects. Physicians should be aware of the possibility of IRIS as a complication of successful antiretroviral therapy in HIV-infected patients with M. haemophilum infection.
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- 2019
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7. Palate ulcer, uvular destruction and nasal septal perforation caused by Sporothrix brasiliensis in an HIV-infected patient.
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Eyer-Silva WA, de Azevedo MCVM, da Silva GAR, Basílio-de-Oliveira RP, de Araujo LF, do Lago IV, Pereira FCF, Fernandes MBT, Figueiredo-Carvalho MHG, Souza Rabello VB, Zancopé-Oliveira RM, Almeida-Paes R, Ferry FRA, and Neves-Motta R
- Abstract
Sporotrichosis is a human and animal disease caused by dimorphic pathogenic species of the genus Sporothrix . We report a dramatic presentation of Sporothrix brasiliensis infection, with destruction of the nasal septum, soft palate, and uvula of an HIV-infected woman. She was successfully treated with amphotericin B deoxycholate followed by itraconazole. Sporotrichosis remains a neglected opportunistic infection in patients with AIDS and awareness of this potentially fatal infection is of utmost importance.
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- 2018
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8. Chlamydia trachomatis asymptomatic urethritis recurrence among males living with HIV-1.
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Silva GARD, Motta HLSN, Souza EFA, Cardoso PANM, Pilotto JH, Eyer-Silva WA, Ribeiro LCP, Santos MSD, Azevedo MCVM, Pinto JFDC, Motta RN, and Ferry FRA
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- AIDS-Related Opportunistic Infections diagnosis, AIDS-Related Opportunistic Infections microbiology, Adult, Asymptomatic Infections epidemiology, Chlamydia Infections diagnosis, Humans, Male, Middle Aged, Prevalence, Prospective Studies, Recurrence, Risk Factors, Urethritis diagnosis, Urethritis microbiology, AIDS-Related Opportunistic Infections epidemiology, Chlamydia Infections epidemiology, Chlamydia trachomatis, Urethritis epidemiology
- Abstract
A prevalence of 3.47% of asymptomatic Chlamydia trachomatis urethritis has been previously reported among males living with HIV infection in Brazil. This study aims to assess the recurrence of C. trachomatis urethritis three years later in the same cohort of patients and analyze associated risk factors. A total of 115 male patients diagnosed with HIV infection, with no symptoms of urethritis and observed since May of 2015 in followup visits were enrolled. They had urine samplers tested by PCR for C. trachomatis and N. gonorrhoeae between February and March 2018. Results: Three of the four patients who had asymptomatic C. trachomatis urethritis three years before were recurrently positive for C. trachomatis urethritis. Two new patients were diagnosed as positives, accounting for a total asymptomatic C. trachomatis urethritis prevalence of 4.34%. The prevalence during the whole study was 5.21%. The relative risk for a new urethritis episode among those previously diagnosed with urethritis is RR=41.62 (95% CI: 9.42-183.84), p < 0.01. Patients who presented asymptomatic urethritis anytime and who were recurrently positive for C. trachomatis had a lower mean age (p<0.01). Married individuals were protected regarding asymptomatic urethritis [p<0.01, OR = 0.04 (0.005-0.4)] and had lower risk to develop recurrence [p<0.01, RR = 0.86 (0.74-0.99)]. Illicit drugs users had risk associated to asymptomatic urethritis [p=0.02, OR= 5.9 (1.03-34)] and higher risk to develop recurrence [p<0.01, RR=1.1 (1-1.22)]. Conclusion: The recurrence of asymptomatic C. trachomatis urethritis after treatment among males living with HIV infection in Brazil can be considered high and should not be neglected.
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- 2018
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9. Drug metabolism and transport gene polymorphisms and efavirenz adverse effects in Brazilian HIV-positive individuals.
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de Almeida TB, de Azevedo MCVM, Pinto JFDC, Ferry FRA, da Silva GAR, de Castro IJ, Baker P, Tanuri A, Haas DW, and Cardoso CC
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- Adult, Aged, Alkynes, Benzoxazines administration & dosage, Brazil, Constitutive Androstane Receptor, Cyclopropanes, Drug-Related Side Effects and Adverse Reactions pathology, Female, Genetic Association Studies, Humans, Male, Middle Aged, Polymorphism, Genetic, Reverse Transcriptase Inhibitors administration & dosage, Benzoxazines adverse effects, Benzoxazines metabolism, Drug-Related Side Effects and Adverse Reactions genetics, HIV Infections drug therapy, Inactivation, Metabolic genetics, Reverse Transcriptase Inhibitors adverse effects, Reverse Transcriptase Inhibitors metabolism
- Abstract
Objectives: There are limited data regarding efavirenz pharmacogenetics in admixed populations. The Brazilian population is highly admixed. In a Brazilian cohort, we sought to characterize associations between efavirenz adverse effects (all-cause and CNS) and polymorphisms in seven genes known or suspected to affect efavirenz metabolism and transport., Methods: We studied 225 HIV-positive individuals who had been prescribed efavirenz-containing regimens at a hospital in Rio de Janeiro, Brazil. Eighty-nine cases had efavirenz adverse effects, including 43 with CNS adverse effects, while 136 controls had no adverse effect of any antiretroviral after treatment for at least 6 months. A total of 67 candidate polymorphisms in ABCB1, CYP2A6, CYP2B6, CYP3A4, CYP3A5, NR1I2 and NR1I3 genes were selected for association analysis. Admixture was assessed using 28 ancestry-informative polymorphisms previously validated for the Brazilian population. Associations were evaluated with logistic regression models adjusted for sex and genetic ancestry., Results: There was extensive African, European and Native American admixture in the cohort. Increased all-cause adverse effects were associated with the CYP2B6 genotype combination 15582CC-516TT-983TT (OR = 7.26, P = 0.003) and with the CYP2B6 slow metabolizer group 516TT or 516GT-983CT (OR = 3.10, P = 0.04). CNS adverse effects were nominally associated with CYP3A4 rs4646437 (OR = 4.63, P = 0.014), but not after adjusting for multiple comparisons., Conclusions: In a highly admixed Brazilian cohort, the CYP2B6 slow metabolizer genotype was associated with an increased risk of efavirenz adverse effects.
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- 2018
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10. A malar rash from inner Rio de Janeiro State, Brazil.
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Eyer-Silva WA, Azevedo MCVM, Silva GARD, and Neves-Motta R
- Abstract
A 49-year-old previously healthy woman from Rio de Janeiro State, Brazil, presented with a right malar rash that started as a tiny pustule and progressed to an ulcerated papulonodular lesion within ten weeks. A presumptive diagnosis of zoonotic sporotrichosis was made based on excellent response to treatment and epidemiological linkage with a diseased cat.
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- 2018
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11. Prevalence of asymptomatic urethritis by Chlamydia trachomatis and Neisseria gonorrhoeae and associated risk factors among males living with HIV-1.
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Silva GARD, Motta HLSN, Souza EFA, Cardoso PANM, Pilotto JH, Eyer-Silva WA, Ribeiro LCP, Santos MSD, Azevedo MCVM, Pinto JFDC, Motta RN, and Ferry FRA
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- AIDS-Related Opportunistic Infections diagnosis, AIDS-Related Opportunistic Infections microbiology, Adolescent, Adult, Brazil epidemiology, Chlamydia Infections diagnosis, Chlamydia trachomatis isolation & purification, Cross-Sectional Studies, Gonorrhea diagnosis, Humans, Male, Middle Aged, Neisseria gonorrhoeae isolation & purification, Risk Factors, Urethritis diagnosis, Urethritis microbiology, AIDS-Related Opportunistic Infections epidemiology, Asymptomatic Infections epidemiology, Chlamydia Infections epidemiology, Gonorrhea epidemiology, Urethritis epidemiology
- Abstract
Objectives: The increase in HIV transmissibility in non-ulcerative sexually transmitted infection is already well-established. It is estimated that symptomatic carriers of N. gonorrhoeae and C. trachomatis have a relative risk of 4.8-fold and 3.6-fold, respectively, for the sexual acquisition of HIV. This type of evaluation for asymptomatic urethritis is necessary to reinforce strategies to combat HIV transmission. This study aims to assess the prevalence of patients with asymptomatic urethritis among men diagnosed with HIV-1 and determine the risk factors associated with this infection., Methods: We enrolled a total of 115 male patients aged 18 years or older who have been diagnosed with HIV infection and have no symptoms of urethritis or other sexually transmitted infections and who have been evaluated between May and August 2015 in a follow-up visit at the Immunology Outpatient Clinic of a Brazilian University Hospital., Results: Four asymptomatic patients were positive for C. trachomatis and were considered asymptomatic carriers of urethritis. Prevalence was 3.47%. Patients who were positive for C. trachomatis urethritis had a lower mean age (p = 0.015)., Conclusion: The presence of asymptomatic sexually transmitted infection is a challenge in clinical practice. We recommend that, in outpatient practice, the habit of inquiring on previous sexual behavior to obtain more information about risks and associations with asymptomatic sexually transmitted infection, a routine physical examination and complementary tests to detect STI pathogens should be performed to discard these conditions. The development of rapid tests for this purpose should also be encouraged.
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- 2018
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12. Oral cavity syphilides.
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Eyer-Silva WA, Azevedo MCVM, and Silva GARD
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- 2018
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13. Laryngeal paracoccidioidomycosis presenting as solitary true vocal fold disease.
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Eyer-Silva WA, Santana AC, Silva GARD, Azevedo MCVM, Barreto JLTMS, Neumann MA, Castro IJ, Basílio-de-Oliveira RP, Araujo LF, Ré NZ, Oliveira FM, Simas CJA, Sarvat MA, and Ferry FRA
- Abstract
Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by Paracoccidioides brasiliensis or P. lutzii . It is a neglected tropical infectious disease that poses a major public health burden in endemic areas of Latin America. Mucosae of the upper digestive and respiratory tracts are commonly involved and many patients have disease at multiple mucosal sites, with or without lung involvement. Mucosal PCM presenting as solitary true vocal fold disease is relatively rare. We present the case of a 67-year-old Brazilian forest guard who presented with a 6-month history of hoarseness and globus pharyngeus due to a solitary left true vocal fold infiltration and vegetation diagnosed as PCM. Silent pulmonary disease was also present. A laryngoscopy video is offered as supplemental material to this report. He completely remitted after surgical removal and amphotericin B deoxycholate treatment.
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- 2017
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14. An unusual case of bacillary angiomatosis in the oral cavity of an AIDS patient who had no concomitant tegumentary lesions - case report and review.
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Eyer-Silva WA, Soares PEMA, Azevedo MCVM, Silva GARD, Signorini DJHP, Neves-Motta R, Pinto JFDC, Moura LM, Basílio-de-Oliveira RP, Araujo LF, Favacho ARM, and Lemos ERS
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- AIDS-Related Opportunistic Infections microbiology, Humans, Male, Middle Aged, Mouth Diseases microbiology, AIDS-Related Opportunistic Infections pathology, Angiomatosis, Bacillary pathology, Mouth Diseases pathology
- Abstract
Bacillary angiomatosis (BA) is an angioproliferative disease of immunocompromised patients that usually presents as vascular tumors in the skin and subcutaneous tissues. It is caused by chronic infections with either Bartonella henselae or B. quintana. Oral cavity BA is exceedingly rare and even rarer without simultaneous cutaneous disease. We report herein the case of a 51-year-old HIV-infected man who presented severe odynophagia and an eroded lesion on the hard palate that progressed to an oronasal fistula. No cutaneous lesions were recorded. Doxycycline led to complete resolution. To the best of our knowledge, only six previous cases of oral BA without tegumentary disease have been previously reported and none of them progressed to fistula.
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- 2017
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15. T-Cell Lymphoma in a Patient with Neurofibromatosis Type 1 and AIDS.
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de Castro IJ, da Silva EBS, Dos Santos TR, de Freitas AB, de Castro IJ, Portela AS, de Magalhães MC, Pires KL, da Silva GAR, and de Azevedo MCVM
- Abstract
Neurofibromatosis type 1 (NF1) and AIDS are risk factors for the development of malignant neoplasms, including hematological malignancies, such as non-Hodgkin lymphoma. NF1 is an autosomal dominant disease that primarily manifests as café-au-lait spots, dermal neurofibromas, axillary and/or inguinal ephelides or freckles, plexiform neurofibromas, Lisch nodules, and bone deformities. In this report, we present a 38-year-old female patient with NF1 from childhood and AIDS who developed peripheral T-cell lymphoma with good response to chemotherapeutic treatment.
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- 2017
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