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29 results on '"Azevedo, Valderilio Feijo"'

2. Rare diseases: What rheumatologists need to know?

Author

do Nascimento, Renan Rodrigues Neves Ribeiro, Piotto, Daniela Gerent Petry, Freire, Eutilia Andrade Medeiros, de Souza Neves, Fabricio, Sztajnbok, Flavio Roberto, Bica, Blanca Elena Rios Gomes, Pinheiro, Frederico Augusto Gurgel, Kozu, Katia Tomie, Pereira, Ivanio Alves, Azevedo, Valderilio Feijo, Cordeiro, Rafael Alves, Giardini, Henrique Ayres Mayrink, Franco, Marco Túlio Muniz, de Fátima Fernandes Carvalho, Margarida, Rosa-Neto, Nilton Salles, and Perazzio, Sandro Félix

Published
2024
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3. Uncovering the knowledge about systemic amyloidosis relevant to the rheumatologists

Author

Pereira, Ivanio Alves, Neto, Nilton Salles Rosa, do Nascimento, Renan Rodrigues Neves Ribeiro, Freire, Eutilia Andrade Medeiros, Neves, Fabricio de Souza, Bica, Blanca Elena Rios Gomes, Pinheiro, Frederico Augusto Gurgel, Perazzio, Sandro Félix, Cordeiro, Rafael Alves, Giardini, Henrique Ayres Mayrink, Azevedo, Valderilio Feijo, and Sztajnbok, Flavio Roberto

Published
2024
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4. Cost minimization and switching management of reference products and their biosimilars in the Brazilian private health system: the case of Unimed Maringa/Custo-minimizacao e gerenciamento de trocas entre produtos de referencia e seus biossimilares no sistema privado de saude no Brasil: o caso da Unimed Maringa

Author

Azevedo, Valderilio Feijo, Rezende, Marcelo Ferreira P., Brovini, Reynaldo Rafael J., Odebrecht, Pamela Cristina A., Moreira, Barbara Eloise V.L., and Guadagnim, Thiago Henrique P.S.

Published
2024
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7. A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study

Author

Airò, Paolo, Alegre-Sancho, Juan Jose, Allanore, Yannick, Ananieva, Lidia P., Ancuta, Codrina, Andrade, Luis Eduardo, Aringer, Martin, Becvar, Radim, Bojinca, Mihai, Butrimiene, Irena, Cantatore, Francesco Paolo, Caporali, Roberto, Caramaschi, Paola, Carreira, Patricia E., Chirieac, Rodica, Corrado, Ada, Cosentino, Vanesa, Cuomo, Giovanna, Czirjak, Laszlo, Da Silva, José Antonio Pereira, la Peña Lefebvre, Paloma García de, De Keyser, Filip, de Souza Müller, Carolina, Damgaard, Kirsten, Damjanov, Nemanja, Denisov, Lev N., Distler, Oliver, Doube, Alan, Dumitrascu, Alina, Engelhart, Merete, Exposito, Marta Valero, Eyerich, Kilian, Farge-Bancel, Dominique, Azevedo, Valderílio Feijó, Foti, Rosario, Frerix, Marc, Gabrielli, Armando, Garen, Torhild, Gottschalk, Paola, Groseanu, Laura, Guiducci, Serena, Günther, Claudia, Hachulla, Eric, Hein, Rüdiger, Heitmann, Stefan, Henes, Jörg, Hesselstrand, Roger, Highton, John, Iannone, Florenzo, Ionescu, Ruxandra Maria, Kayser, Cristiane, Karpec, Diana, Kerzberg, Eduardo, Kotulska, Anna, Kopec-Medrek, Magdalena, Kucharz, Eugene, Krummel-Lorenz, Brigitte, Lauffer, Felix, Launay, David, Li, Mengtao, Litinsky, Ira, Loyo, Esthela, Cerinic, Marco Matucci, Meroni, Pierluigi, Midtvedt, Øyvind, Mihai, Carmen Marina, Montecucco, Carlomaurizio, Montoya, Fabiana, Morgiel, Ewa, Mouthon, Luc, Müller-Ladner, Ulf, Nielsen, Henrik, Opris, Daniela, Ortiz-Santamaria, Vera, Otsa, Kati, Pileckyte, Margarita, Pisarri, Simonetta, Popescu, Monica, Pozzi, Maria Rosa, Puppo, Francesco, Radominski, Sebastião Cezar, Riccieri, Valeria, Rosato, Edoardo, Rozman, Blaz, Rubio, Silvia Rodriguez, Rugiene, Rita, Saar, Petra, Salvador, Maria João, Seidel, Matthias, Sokolik, Renata, Solanki, Kamal, Stamenkovic, Bojana, Stankovic, Aleksandra, Stebbings, Simon, Strauss, Gitte, Sulli, Alberto, Szamosi, Szilvia, Szechinski, Jacek, Szmyrka-Kaczmarek, Magdalena, Szücs, Gabriella, Tanaseanu, Cristina-Mihaela, Tiglea, Isabela, Tyndall, Alan, Ughi, Nicola, Uprus, Maria, Vacca, Alessandra, Varju, Cecilia, Venalis, Algirdas, Venalis, Paulius, Walker, Ulrich A., Widuchowska, Malgorzata, Wiland, Piotr, Wuttge, Dirk M., Zeni, Silvana, Zenone, Thierry, Ingegnoli, Francesca, Boracchi, Patrizia, Gualtierotti, Roberta, Smith, Vanessa, Cutolo, Maurizio, and Foeldvari, Ivan

Published
2015
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8. Recommendations on the use of biosimilars by the Brazilian Society of Rheumatology, Brazilian Society of Dermatology, Brazilian Federation of Gastroenterology and Brazilian Study Group on Inflammatory Bowel Disease—Focus on clinical evaluation of monoclonal antibodies and fusion proteins used in the treatment of autoimmune diseases

Author

Azevedo, Valderílio Feijó, de Souza Meirelles, Eduardo, Kochen, Jussara de Almeida Lima, Medeiros, Ana Cristina, Miszputen, Sender J., Teixeira, Fábio Vieira, Damião, Adérson Osmar Mourão Cintra, Kotze, Paulo Gustavo, Romiti, Ricardo, Arnone, Marcelo, Ferreira Magalhães, Renata, Maia, Cláudia Pires Amaral, and de Carvalho, André Vicente E.

Published
2015
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14. The development of candidate composite disease activity and responder indices for psoriatic arthritis (GRACE project)

Author

Helliwell, Philip S, FitzGerald, Oliver, Fransen, Jaap, Gladman, Dafna D, Kreuger, Gerald G, Callis-Duffin, Kristina, McHugh, Neil, Mease, Philip J, Strand, Vibeke, Waxman, Robin, Azevedo, Valderilio Feijo, Beltran Ostos, Adriana, Carneiro, Sueli, Cauli, Alberto, Espinoza, Luis R, Flynn, John A, Hassan, Nada, Healy, Paul, Kerzberg, Eduardo Mario, Lee, Yun Jong, Lubrano, Ennio, Marchesoni, Antonio, Marzo-Ortega, Helena, Porru, Giovanni, Moreta, Elvia G, Nash, Peter, Raffayova, Helena, Ranza, Roberto, Raychaudhuri, Siba P, Roussou, Euthalia, Scarpa, Raphael, Song, Yeong Wook, Soriano, Enrique R, Tak, Paul P, Ujfalussy, Ilona, de Vlam, Kurt, and Walsh, Jessica A

Published
2013
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15. High levels of immunosuppression are related to unfavourable outcomes in hospitalised patients with rheumatic diseases and COVID-19: first results of ReumaCoV Brasil registry

Author

Marques, Claudia Diniz Lopes, primary, Kakehasi, Adriana Maria, additional, Pinheiro, Marcelo Medeiros, additional, Mota, Licia Maria Henrique, additional, Albuquerque, Cleandro Pires, additional, Silva, Carolina Rocha, additional, Santos, Gabriela Porfirio Jardim, additional, Reis-Neto, Edgard Torres, additional, Matos, Pedro, additional, Devide, Guilherme, additional, Dantas, Andrea, additional, Giorgi, Rina Dalva, additional, Omura, Felipe, additional, Marinho, Adriana de Oliveira, additional, Valadares, Lilian David Azevedo, additional, Melo, Ana Karla G, additional, Ribeiro, Francinne Machado, additional, Ferreira, Gilda Aparecida, additional, Santos, Flavia Patricia de Sena, additional, Ribeiro, Sandra Lucia Euzebio, additional, Andrade, Nicole Pamplona Bueno, additional, Yazbek, Michel Alexandre, additional, Souza, Viviane Angelina de, additional, Paiva, Eduardo S, additional, Azevedo, Valderilio Feijo, additional, Freitas, Ana Beatriz Santos Bacchiega de, additional, Provenza, José Roberto, additional, Toledo, Ricardo Acayaba de, additional, Fontenelle, Sheilla, additional, Carneiro, Sueli, additional, Xavier, Ricardo, additional, Pileggi, Gecilmara Cristina Salviato, additional, and Reis, Ana Paula Monteiro Gomides, additional

Published
2021
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16. Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: A European Scleroderma Trials and Research (EUSTAR) analysis

Author

Becker, Mike, Graf, Nicole, Sauter, Rafael, Allanore, Yannick, Curram, John, Denton, Christopher P., Khanna, Dinesh, Matucci-Cerinic, Marco, Pena, Janethe de Oliveira, Pope, Janet E., Distler, Oliver, Guiducci, Serena, Walker, Ulrich, Jaeger, Veronika, Bannert, Bettina, Lapadula, Giovanni, Becvarare, Radim, Cutolo, Maurizio, Valentini, Gabriele, Siegert, Elise, Rednic, Simona, Montecucco, C., Carreira, Patricia E., Novak, Srdan, Czirjak, Laszlo, Varju, Cecilia, Chizzolini, Carlo, Allai, Daniela, Kucharz, Eugene J., Cozzi, Franco, Rozman, Blaz, Mallia, Carmel, Gabrielli, Armando, Bancel, Dominique Farge, Airo, Paolo, Hesselstrand, Roger, Martinovic, Duska, Balbir-Gurman, Alexandra, Braun-Moscovici, Yolanda, Hunzelmann, Nicolas, Pellerito, Raffaele, Caramaschi, Paola, Black, Carol, Damjanov, Nemanja, Henes, Joerg, Ortiz Santamaria, Vera, Heitmann, Stefan, Seidel, Matthias, Pereira Da Silva, Jose Antonio, Stamenkovic, Bojana, Selmi, Carlo Francesco, Tikly, Mohammed, Denisov, Lev N., Mueller-Ladner, Ulf, Engelhart, Merete, Hachulla, Eric, Riccieri, Valeria, Ionescu, Ruxandra Maria, Mihai, Carina, Sunderkoetter, Cord, Kuhn, Annegret, Schett, Georg, Distler, Joerg, Meroni, Pierluigi, Ingegnoli, Francesca, Mouthon, Luc, De Keyser, Filip, Smith, Vanessa, Cantatore, Francesco Paolo, Corrado, Ada, Ullman, Susanne, Iversen, Line, Pozzi, Maria Rosa, Eyerich, Kilian, Hein, Ruediger, Knott, Elisabeth, Wiland, Piotr, Szmyrka-Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Madej, Marta, Jose Alegre-Sancho, Juan, Krummel-Lorenz, Brigitte, Saar, Petra, Aringer, Martin, Guenther, Claudia, Anne, Erler, Westhovens, Rene, De langhe, Ellen, Lenaerts, Jan, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Uprus, Maria, Otsa, Kati, Yavuz, Sule, Radominski, Sebastiao Cezar, Mueller, Carolina de Souza, Azevedo, Valderilio Feijo, Popa, Sergei, Zenone, Thierry, Stebbings, Simon, Highton, John, Mathieu, Alessandro, Vacca, Alessandra, Stamp, Lisa, Chapman, Peter, O'Donnell, John, Solanki, Kamal, Doube, Alan, Veale, Douglas, O'Rourke, Marie, Loyo, Esthela, Li, Mengtao, Rosato, Edoardo, Amoroso, Antonio, Gigante, Antonietta, Oksel, Fahrettin, Yargucu, Figen, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Dumitrascu, Alina, Tiglea, Isabela, Foti, Rosario, Visalli, Elisa, Benenati, Alessia, Amato, Giorgio, Ancuta, Codrina, Chirieac, Rodica, Villiger, Peter, Adler, Sabine, Dan, Diana, de la Pena Lefebvre, Paloma Garcia, Rodriguez Rubio, Silvia, Valero Exposito, Marta, Sibilia, Jean, Chatelus, Emmanuel, Gottenberg, Jacques Eric, Chifflot, Helene, Litinsky, Ira, Del Galdo, Francesco, Venalis, Algirdas, Saketkoo, Lesley Ann, Lasky, Joseph A., Kerzberg, Eduardo, Montoya, Fabiana, Cosentino, Vanesa, Limonta, Massimiliano, Brucato, Antonio Luca, Lupi, Elide, Spertini, Francois, Ribi, Camillo, Buss, Guillaume, Martin, Thierry, Guffroy, Aurelien, Poindron, Vincent, Chung, Lori, Schmeiser, Tim, Zebryk, Pawel, Riso, Nuno, Riemekasten, Gabriela, Rezus, Elena, Puttini, Piercarlo Sarzi, Ege Üniversitesi, University of Zurich, Distler, Oliver, Chizzolini, Carlo, Allai, Daniela, Becker, M., Graf, N., Sauter, R., Allanore, Y., Curram, J., Denton, C. P., Khanna, D., Matucci-Cerinic, M., de Oliveira Pena, J., Pope, J. E., Distler, O., Guiducci, S., Walker, U., Jaeger, V., Bannert, B., Lapadula, G., Becvarare, R., Cutolo, M., Valentini, G., Siegert, E., Rednic, S., Montecucco, C., Carreira, P. E., Novak, S., Czirjak, L., Varju, C., Chizzolini, C., Allai, D., Kucharz, E. J., Cozzi, F., Rozman, B., Mallia, C., Gabrielli, A., Bancel, D. F., Airo, P., Hesselstrand, R., Martinovic, D., Balbir-Gurman, A., Braun-Moscovici, Y., Hunzelmann, N., Pellerito, R., Caramaschi, P., Black, C., Damjanov, N., Henes, J., Santamaria, V. O., Heitmann, S., Seidel, M., Pereira Da Silva, J. A., Stamenkovic, B., Selmi, C. F., Tikly, M., Denisov, L. N., Muller-Ladner, U., Engelhart, M., Hachulla, E., Riccieri, V., Ionescu, R. M., Mihai, C., Sunderkotter, C., Kuhn, A., Schett, G., Distler, J., Meroni, P., Ingegnoli, F., Mouthon, L., De Keyser, F., Smith, V., Cantatore, F. P., Corrado, A., Ullman, S., Iversen, L., Pozzi, M. R., Eyerich, K., Hein, R., Knott, E., Wiland, P., Szmyrka-Kaczmarek, M., Sokolik, R., Morgiel, E., Madej, M., Alegre-Sancho, J. J., Krummel-Lorenz, B., Saar, P., Aringer, M., Gunther, C., Anne, E., Westhovens, R., De Langhe, E., Lenaerts, J., Anic, B., Baresic, M., Mayer, M., Uprus, M., Otsa, K., Yavuz, S., Radominski, S. C., de Souza Muller, C., Azevedo, V. F., Popa, S., Zenone, T., Stebbings, S., Highton, J., Mathieu, A., Vacca, A., Stamp, L., Chapman, P., O'Donnell, J., Solanki, K., Doube, A., Veale, D., O'Rourke, M., Loyo, E., Li, M., Rosato, E., Amoroso, A., Gigante, A., Oksel, F., Yargucu, F., Tanaseanu, C. -M., Popescu, M., Dumitrascu, A., Tiglea, I., Foti, R., Visalli, E., Benenati, A., Amato, G., Ancuta, C., Chirieac, R., Villiger, P., Adler, S., Dan, D., de la Pena Lefebvre, P. G., Rubio, S. R., Exposito, M. V., Sibilia, J., Chatelus, E., Gottenberg, J. E., Chifflot, H., Litinsky, I., Del Galdo, F., Venalis, A., Saketkoo, L. A., Lasky, J. A., Kerzberg, E., Montoya, F., Cosentino, V., Limonta, M., Brucato, A. L., Lupi, E., Spertini, F., Ribi, C., Buss, G., Martin, T., Guffroy, A., Poindron, V., Chung, L., Schmeiser, T., Zebryk, P., Riso, N., Riemekasten, G., Rezus, E., and Sarzi Puttini, P.

Subjects
INVOLVEMENT, SELECTION, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences, diffuse, predictive factors, systemic sclerosis, 2745 Rheumatology, epidemiologic methods, morbidity, Disease, Immunology, General Biochemistry, Genetics and Molecular Biology, Immunology and Allergy, Rheumatology, INTERSTITIAL LUNG-DISEASE, disease worsening, mortality, predictive factors, systemic sclerosis, predictive factor, disease worsening, DESIGN, middle aged, Medicine and Health Sciences, FIBROSIS, scleroderma, SKIN THICKNESS SCORE, mortality, skin and connective tissue diseases, Prospective cohort study, humans, lung diseases, ddc:616, education.field_of_study, heart diseases, integumentary system, clinical trials as topic, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti, 10051 Rheumatology Clinic and Institute of Physical Medicine, Interstitial lung disease, follow-up studies, ddc, female, Cohort, 2723 Immunology and Allergy, europe, Life Sciences & Biomedicine, CLINICAL-TRIALS, survival rate, medicine.medical_specialty, Population, 610 Medicine & health, disease progression, male, 1300 General Biochemistry, Genetics and Molecular Biology, Internal medicine, Severity of illness, REGRESSION, medicine, severity of illness index, education, Survival rate, METAANALYSIS, 2403 Immunology, Science & Technology, Scleroderma, Systemic, business.industry, MORTALITY, systemic, medicine.disease, prospective studies, Clinical trial, prognosis, scleroderma, diffuse, scleroderma, systemic, Scleroderma, Diffuse, business
Abstract

PubMed: 31227488, Objectives Mortality and worsening of organ function are desirable endpoints for clinical trials in systemic sclerosis (SSc). The aim of this study was to identify factors that allow enrichment of patients with these endpoints, in a population of patients from the European Scleroderma Trials and Research group database. Methods Inclusion criteria were diagnosis of diffuse SSc and follow-up over 12±3 months. Disease worsening/organ progression was fulfilled if any of the following events occurred: new renal crisis; decrease of lung or heart function; new echocardiography-suspected pulmonary hypertension or death. In total, 42 clinical parameters were chosen as predictors for the analysis by using (1) imputation of missing data on the basis of multivariate imputation and (2) least absolute shrinkage and selection operator regression. Results Of 1451 patients meeting the inclusion criteria, 706 had complete data on outcome parameters and were included in the analysis. Of the 42 outcome predictors, eight remained in the final regression model. There was substantial evidence for a strong association between disease progression and age, active digital ulcer (DU), lung fibrosis, muscle weakness and elevated C-reactive protein (CRP) level. Active DU, CRP elevation, lung fibrosis and muscle weakness were also associated with a significantly shorter time to disease progression. A bootstrap validation step with 10 000 repetitions successfully validated the model. Conclusions The use of the predictive factors presented here could enable cohort enrichment with patients at risk for overall disease worsening in SSc clinical trials. © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ., Bayer Bayer, United Kingdom Université Paris Descartes Li Ka Shing Foundation, LKSF University of Michigan, U-M, 1Department of Rheumatology and the Centre of experimental Rheumatology, University Hospital Zurich, Zurich, switzerland 2Graf Biostatistics, Winterthur, switzerland 3Big Data institute, li Ka shing Centre for Health information and Discovery, nuffield Department of Medicine, University of Oxford, Oxford, UK 4Rheumatology a Department, Paris Descartes University, sorbonne Paris Cité, Cochin Hospital, Paris, France 5Data science and analytics, Bayer plc, Reading, UK 6UCl Division of Medicine, Royal Free Campus, london, UK 7Division of Rheumatology, Department of internal Medicine, University of Michigan scleroderma Program, University of Michigan, ann arbor, Michigan, Usa 8Department of experimental and Clinical Medicine, University of Florence, Florence, italy 9Bayer Us llC, Whippany, new Jersey, Usa 10Department of Medicine, Division of Rheumatology, University of Western Ontario, st. Joseph’s Health Care, london, Ontario, Canada Acknowledgements The R-code for the linear Mi-lassO was received from Qixuan Chen.21 Medical writing assistance was provided by adelphi Communications ltd (Bollington, UK), funded by Bayer aG (Berlin, Germany)., Contributors study conception and design, acquisition of data, analysis and interpretation of data and drafting and revising the article: OD and MB; analysis and interpretation of data: OD, MB, Rs and nG. all authors have critically reviewed and approved the final submitted version to be published. Funding This study was supported by a grant from Bayer aG. Bayer employees are coauthors of this paper and supported the study design and interpretation of the data, but otherwise Bayer had no influence on the study., Competing interests MOB declares no conflict of interest. OD has had consultancy relationships with actelion, Bayer, Biogen idec, Boehringer ingelheim, Chemomab, espeRare foundation, Genentech/Roche, GsK, inventiva, italfarmaco, lilly, medac, Medimmune, Mitsubishi Tanabe Pharma, Pharmacyclics, novartis, Pfizer, sanofi, sinoxa and UCB in the area of potential treatments of scleroderma and its complications. OD has received research funding from actelion, Bayer, Boehringer ingelheim, Mitsubishi Tanabe Pharma and Roche in the area of potential treatments of scleroderma and its complications. OD has a patent for mir-29 licensed for the treatment of systemic sclerosis. DK has consultancy relationships and/or has received grant/research support from Bayer, Bristol-Myers squibb, Boehringer ingelheim, Genentech/Roche, niH, Pfizer, sanofi-aventis Pharmaceuticals, actelion Pharmaceuticals Us, Chemomab, Corbus, Covis, Cytori, eicos, eMD serono, Gilead, GlaxosmithKline, and UCB Pharma. He is a shareholder of eicos. CPD has consultancy relationships with and/or has received speakers’ bureau fees from actelion Pharmaceuticals Us, Bayer aG, GlaxosmithKline, Csl Behring, Merck serono, Roche Pharmaceuticals, Genentech and Biogen iDeC inc., inventiva, sanofi-aventis Pharmaceuticals and Boehringer ingelheim. JeP has consultancy relationships with and/or has received grant/research support from actelion, Bayer aG, Bristol-Myers squibb, Merck, Pfizer inc. and Roche. MM-C has consultancy relationships and/ or has received grant/research support from Pfizer, Bristol-Myers squibb, actelion, UCB Pharma, Bayer, Chemomab, Genentech/Roche, inventiva and lilly. Ya has consultancy relationships with and/or has received grant/research support from actelion, Pharmaceuticals Us, Bayer aG, Bristol-Myers squibb, inventiva, Medac, Pfizer inc., Roche Pharmaceuticals, Genentech and Biogen iDeC inc., sanofi-aventis Pharmaceuticals and servier. JdOP and JC are employees of Bayer. nTG has nothing to disclose.

Published
2019

17. Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the european scleroderma trials and research (eustar) cohort

Author

Wu, Wanlong, Jordan, Suzana, Graf, Nicole, Pena, Janethe de Oliveira, Curram, John, Allanore, Yannick, Matucci-Cerinic, Marco, Pope, Janet E., Denton, Christopher P., Khanna, Dinesh, Distler, Oliver, Guiducci, Serena, Walker, Ulrich, Jaeger, Veronika, Bannert, Bettina, Lapadula, Giovanni, Becvarare, Radim, Cutolo, Maurizio, Valentini, Gabriele, Siegert, Elise, Rednic, Simona, Montecucco, C., Carreira, Patricia E., Novak, Srdan, Czirjak, Laszlo, Varju, Cecilia, Chizzolini, Carlo, Allai, Daniela, Kucharz, Eugene J., Cozzi, Franco, Rozman, Blaz, Mallia, Carmel, Gabrielli, Armando, Bancel, Dominique Farge, Airo, Paolo, Hesselstrand, Roger, Martinovic, Duska, Balbir-Gurman, Alexandra, Braun-Moscovici, Yolanda, Hunzelmann, Nicolas, Pellerito, Raffaele, Caramaschi, Paola, Black, Carol, Damjanov, Nemanja, Henes, Joerg, Ortiz Santamaria, Vera, Heitmann, Stefan, Seidel, Matthias, Pereira Da Silva, Jose Antonio, Stamenkovic, Bojana, Selmi, Carlo Francesco, Tikly, Mohammed, Denisov, Lev N., Mueller-Ladner, Ulf, Engelhart, Merete, Hachulla, Eric, Riccieri, Valeria, Ionescu, Ruxandra Maria, Mihai, Carina, Sunderkoetter, Cord, Kuhn, Annegret, Schett, Georg, Distler, Joerg, Meroni, Pierluigi, Ingegnoli, Francesca, Mouthon, Luc, De Keyser, Filip, Smith, Vanessa, Cantatore, Francesco Paolo, Corrado, Ada, Ullman, Susanne, Iversen, Line, Pozzi, Maria Rosa, Eyerich, Kilian, Hein, Ruediger, Knott, Elisabeth, Wiland, Piotr, Szmyrka-Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Madej, Marta, Jose Alegre-Sancho, Juan, Krummel-Lorenz, Brigitte, Saar, Petra, Aringer, Martin, Guenther, Claudia, Anne, Erler, Westhovens, Rene, De Langhe, Ellen, Lenaerts, Jan, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Uprus, Maria, Otsa, Kati, Yavuz, Sule, Radominski, Sebastiao Cezar, Mueller, Carolina de Souza, Azevedo, Valderilio Feijo, Popa, Sergei, Zenone, Thierry, Stebbings, Simon, Highton, John, Mathieu, Alessandro, Vacca, Alessandra, Stamp, Lisa, Chapman, Peter, O'Donnell, John, Solanki, Kamal, Doube, Alan, Veale, Douglas, O'Rourke, Marie, Loyo, Esthela, Li, Mengtao, Rosato, Edoardo, Amoroso, Antonio, Gigante, Antonietta, Oksel, Fahrettin, Yargucu, Figen, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Dumitrascu, Alina, Tiglea, Isabela, Foti, Rosario, Visalli, Elisa, Benenati, Alessia, Amato, Giorgio, Ancuta, Codrina, Chirieac, Rodica, Villiger, Peter, Adler, Sabine, Dan, Diana, de la Pena Lefebvre, Paloma Garcia, Rodriguez Rubio, Silvia, Valero Exposito, Marta, Sibilia, Jean, Chatelus, Emmanuel, Gottenberg, Jacques Eric, Chifflot, Helene, Litinsky, Ira, Del Galdo, Francesco, Venalis, Algirdas, Saketkoo, Lesley Ann, Lasky, Joseph A., Kerzberg, Eduardo, Montoya, Fabiana, Cosentino, Vanesa, Limonta, Massimiliano, Brucato, Antonio Luca, Lupi, Elide, Spertini, Francois, Ribi, Camillo, Buss, Guillaume, Martin, Thierry, Guffroy, Aurelien, Poindron, Vincent, Chung, Lori, Schmeiser, Tim, Zebryk, Pawel, Riso, Nuno, Riemekasten, Gabriela, Rezus, Elena, Puttini, Piercarlo Sarzi, Wu, W., Jordan, S., Graf, N., de Oliveira Pena, J., Curram, J., Allanore, Y., Matucci-Cerinic, M., Pope, J. E., Denton, C. P., Khanna, D., Distler, O., Guiducci, S., Walker, U., Jaeger, V., Bannert, B., Lapadula, G., Becvarare, R., Cutolo, M., Valentini, G., Siegert, E., Rednic, S., Montecucco, C., Carreira, P. E., Novak, S., Czirjak, L., Varju, C., Chizzolini, C., Allai, D., Kucharz, E. J., Cozzi, F., Rozman, B., Mallia, C., Gabrielli, A., Bancel, D. F., Airo, P., Hesselstrand, R., Martinovic, D., Balbir-Gurman, A., Braun-Moscovici, Y., Hunzelmann, N., Pellerito, R., Caramaschi, P., Black, C., Damjanov, N., Henes, J., Santamaria, V. O., Heitmann, S., Seidel, M., Pereira Da Silva, J. A., Stamenkovic, B., Selmi, C. F., Tikly, M., Denisov, L. N., Muller-Ladner, U., Engelhart, M., Hachulla, E., Riccieri, V., Ionescu, R. M., Mihai, C., Sunderkotter, C., Kuhn, A., Schett, G., Distler, J., Meroni, P., Ingegnoli, F., Mouthon, L., De Keyser, F., Smith, V., Cantatore, F. P., Corrado, A., Ullman, S., Iversen, L., Pozzi, M. R., Eyerich, K., Hein, R., Knott, E., Wiland, P., Szmyrka-Kaczmarek, M., Sokolik, R., Morgiel, E., Madej, M., Alegre-Sancho, J. J., Krummel-Lorenz, B., Saar, P., Aringer, M., Gunther, C., Anne, E., Westhovens, R., De Langhe, E., Lenaerts, J., Anic, B., Baresic, M., Mayer, M., Uprus, M., Otsa, K., Yavuz, S., Radominski, S. C., de Souza Muller, C., Azevedo, V. F., Popa, S., Zenone, T., Stebbings, S., Highton, J., Mathieu, A., Vacca, A., Stamp, L., Chapman, P., O'Donnell, J., Solanki, K., Doube, A., Veale, D., O'Rourke, M., Loyo, E., Li, M., Rosato, E., Amoroso, A., Gigante, A., Oksel, F., Yargucu, F., Tanaseanu, C. -M., Popescu, M., Dumitrascu, A., Tiglea, I., Foti, R., Visalli, E., Benenati, A., Amato, G., Ancuta, C., Chirieac, R., Villiger, P., Adler, S., Dan, D., de la Pena Lefebvre, P. G., Rubio, S. R., Exposito, M. V., Sibilia, J., Chatelus, E., Gottenberg, J. E., Chifflot, H., Litinsky, I., Del Galdo, F., Venalis, A., Saketkoo, L. A., Lasky, J. A., Kerzberg, E., Montoya, F., Cosentino, V., Limonta, M., Brucato, A. L., Lupi, E., Spertini, F., Ribi, C., Buss, G., Martin, T., Guffroy, A., Poindron, V., Chung, L., Schmeiser, T., Zebryk, P., Riso, N., Riemekasten, G., Rezus, E., Sarzi Puttini, P., Ege Üniversitesi, Chizzolini, Carlo, Allali, Danièle, University of Zurich, and Distler, Oliver

Subjects
INVOLVEMENT, Male, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences, diffuse, Time Factors, Databases, Factual, Skin Diseases/etiology/mortality/physiopathology, PREDICTION, Fibrosi, 2745 Rheumatology, Diffuse/complications/mortality/pathology, Immunology, General Biochemistry, Genetics and Molecular Biology, Immunology and Allergy, Rheumatology, Kaplan-Meier Estimate, ddc:616.07, Severity of Illness Index, Scleroderma, Cohort Studies, PROGNOSTIC-FACTORS, Fibrosis, Medicine and Health Sciences, scleroderma, Lung, Skin, integumentary system, progressive skin fibrosis, Lung function decline, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti, 10051 Rheumatology Clinic and Institute of Physical Medicine, DEATH, Middle Aged, ddc, Europe, VARIABILITY, factual, Cohort, Visceral organ progression, 2723 Immunology and Allergy, Disease Progression, Female, Survival Analysi, Life Sciences & Biomedicine, Cohort study, Human, Adult, Skin/pathology, medicine.medical_specialty, databases, All-cause death, risk analysis, diffuse cutaneous systemic sclerosis, 610 Medicine & health, IMPROVEMENT, Systemic Sclerosis, Skin Diseases, THICKNESS SCORE, VALIDATION, Databases, FEV1/FVC ratio, 1300 General Biochemistry, Genetics and Molecular Biology, Internal medicine, medicine, Humans, Factual, Survival analysis, 2403 Immunology, Science & Technology, Proportional hazards model, business.industry, Surrogate endpoint, MORTALITY, Skin Disease, fibrosis, Progressive skin fibrosi, Lung/physiopathology, biomarkers, Diffuse cutaneous systemic sclerosi, medicine.disease, Survival Analysis, all-cause death, lung function decline, visceral organ progression, adult, cohort studies, databases, factual, disease progression, female, humans, Scleroderma, Diffuse, Cohort Studie, business
Abstract

PubMed: 30852552, Objectives To determine whether progressive skin fibrosis is associated with visceral organ progression and mortality during follow-up in patients with diffuse cutaneous systemic sclerosis (dcSSc). Methods We evaluated patients from the European Scleroderma Trials and Research database with dcSSc, baseline modified Rodnan skin score (mRSS) ?7, valid mRSS at 12±3 months after baseline and ?1 annual follow-up visit. Progressive skin fibrosis was defined as an increase in mRSS >5 and ?25% from baseline to 12±3 months. Outcomes were pulmonary, cardiovascular and renal progression, and all-cause death. Associations between skin progression and outcomes were evaluated by Kaplan-Meier survival analysis and multivariable Cox regression. Results Of 1021 included patients, 78 (7.6%) had progressive skin fibrosis (skin progressors). Median follow-up was 3.4 years. Survival analyses indicated that skin progressors had a significantly higher probability of FVC decline ?10% (53.6% vs 34.4%; p, Bayer Bayer, 1Department of Rheumatology, University Hospital Zurich, Zurich, switzerland 2Graf Biostatistics, Winterthur, switzerland 3Clinical Development Pulmonology, Bayer Us llC, Whippany, new Jersey, Usa 4Data science and analytics, Bayer plc, Reading, UK 5Rheumatology a Department, Paris Descartes University, inseRM U1016, sorbonne, Paris Cité, Cochin Hospital, Paris, France 6Division of Rheumatology, University of Florence, Florence, italy 7Department of Medicine, Division of Rheumatology, University of Western Ontario, st. Joseph’s Health Care, london, Western Ontario, Canada 8Department of Rheumatology, Royal Free Hospital, University College london, london, UK 9scleroderma Program, Department of internal Medicine, Division of Rheumatology, University of Michigan, ann arbor, Michigan, Usa Acknowledgements The authors thank nicole schneider for excellent administration and data entry into the eUsTaR cohort. Medical writing assistance was provided by adelphi Communications ltd (Bollington, UK), funded by Bayer aG (Berlin, Germany)., This study was supported by a grant from Bayer aG.

Published
2019

18. Phenotypes determined by cluster analysis and their survival in the prospective European Scleroderma Trials and Research cohort of patients with systemic sclerosis

Author

Sobanski, Vincent, Giovannelli, Jonathan, Allanore, Yannick, Riemekasten, Gabriela, Airo, Paolo, Vettori, Serena, Cozzi, Franco, Distler, Oliver, Matucci-Cerinic, Marco, Denton, Christopher, Launay, David, Hachulla, Eric, Cerinic, Marco Matucci, Guiducci, Serena, Walker, Ulrich, Kyburz, Diego, Lapadula, Giovanni, Iannone, Florenzo, Maurer, Britta, Jordan, Suzana, Becvar, Radim, Sierakowsky, Stanislaw, Bielecka, Otylia Kowal, Cutolo, Maurizio, Sulli, Alberto, Valentini, Gabriele, Cuomo, Giovanna, Siegert, Elise, Rednic, Simona, Nicoara, Ileana, Kahan, Andre, Vlachoyiannopoulos, Panayiotis, Montecucco, Carlo, Caporali, Roberto, Stork, Jiri, Inanc, Murat, Carreira, Patricia E, Novak, Srdan, Czirjak, Laszlo, Varju, Cecilia, Chizzolini, Carlo, Kucharz, Eugene J, Kotulska, Anna, Kopec-Medrek, Magdalena, Widuchowska, Malgorzata, Rozman, Blaz, Mallia, Carmel, Coleiro, Bernard, Gabrielli, Armando, Farge, Dominique, Wu, Chen, Marjanovic, Zora, Faivre, Helene, Hij, Darin, Dhamadi, Roza, Hesselstrand, Roger, Wollheim, Frank, Wuttge, Dirk M, Andreasson, Kristofer, Martinovic, Duska, Balbir-Gurman, Alexandra, Braun-Moscovici, Yolanda, Trotta, Francesco, Lo Monaco, Andrea, Hunzelmann, Nicolas, Pellerito, Raffaele, Bambara, Lisa Maria, Caramaschi, Paola, Morovic-Vergles, Jadranka, Black, Carol, Damjanov, Nemanja, Henes, Joerg, Ortiz Santamaria, Vera, Heitmann, Stefan, Krasowska, Dorota, Seidel, Matthias, Hasler, Paul, Burkhardt, Harald, Himsel, Andrea, Bajocchi, Gianluigi, Nuova, Arcispedale Santa Maria, Salvador, Maria Joao, Pereira Da Silva, Jose Antonio, Stamenkovic, Bojana, Stankovic, Aleksandra, Selmi, Carlo Francesco, De Santis, Maria, Marasini, Bianca, Tikly, Mohammed, Ananieva, Lidia P, Denisov, Lev N, Mueller-Ladner, Ulf, Frerix, Marc, Tarner, Ingo, Scorza, Raffaella, Puppo, Francesco, Engelhart, Merete, Strauss, Gitte, Nielsen, Henrik, Damgaard, Kirsten, Szucs, Gabriella, Szamosi, Szilvia, Zea Mendoza, Antonio, de la Puente, Carlos, Sifuentes Giraldo, Walter Alberto, Midtvedt, Oyvind, Reiseter, Silje, Garen, Torhild, Valesini, Guido, Riccieri, Valeria, Ionescu, Ruxandra Maria, Opris, Daniela, Groseanu, Laura, Wigley, Fredrick M, Cornateanu, Roxana Sfrent, Ionitescu, Razvan, Gherghe, Ana Maria, Soare, Alina, Gorga, Marilena, Bojinca, Mihai, Mihai, Carina, Milicescu, Mihaela, Sunderkoetter, Cord, Kuhn, Annegret, Sandorfi, Nora, Schett, Georg, Distler, Joerg HW, Beyer, Christian, Meroni, Pierluigi, Ingegnoli, Francesca, Mouthon, Luc, De Keyser, Filip, Smith, Vanessa, Cantatore, Francesco Paolo, Corrado, Ada, Ullman, Susanne, Iversen, Line, von Muehlen, Carlos Alberto, Bohn, Jussara Marilu, Lonzetti, Lilian Scussel, Pozzi, Maria Rosa, Eyerich, Kilian, Hein, Ruediger, Knott, Elisabeth, Wiland, Piotr, Szmyrka-Kaczmarek, Magdalena, Sokolik, Renata, Morgiel, Ewa, Madej, Marta, Houssiau, Frederic A, Jose Alegre-Sancho, Juan, Krummel-Lorenz, Brigitte, Saar, Petra, Aringer, Martin, Guenther, Claudia, Westhovens, Rene, de Langhe, Ellen, Lenaerts, Jan, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Uprus, Maria, Otsa, Kati, Yavuz, Sule, Granel, Brigitte, Radominski, Sebastiao Cezar, Mueller, Carolina de Souza, Azevedo, Valderilio Feijo, Jimenez, Sergio, Busquets, Joanna, Agachi, Svetlana, Groppa, Liliana, Chiaburu, Lealea, Russu, Eugen, Popa, Sergei, Zenone, Thierry, Pileckyte, Margarita, Stebbings, Simon, Highton, John, Mathieu, Alessandro, Vacca, Alessandra, Sampaio-Barros, Percival D, Yoshinari, Natalino H, Marangoni, Roberta G, Martin, Patricia, Fuocco, Luiza, Stamp, Lisa, Chapman, Peter, O'Donnell, John, Solanki, Kamal, Doube, Alan, Veale, Douglas, O'Rourke, Marie, Loyo, Esthela, Li, Mengtao, Mohamed, Walid Ahmed Abdel Atty, Rosato, Edoardo, Amoroso, Antonio, Gigante, Antonietta, Oksel, Fahrettin, Yargucu, Figen, Tanaseanu, Cristina-Mihaela, Popescu, Monica, Dumitrascu, Alina, Tiglea, Isabela, Foti, Rosario, Chirieac, Rodica, Ancuta, Codrina, Furst, Daniel E, Villiger, Peter, Adler, Sabine, van Laar, Jacob, Kayser, Cristiane, Eduardo, Andrade Luis C, Fathi, Nihal, Hassanien, Manal, de la Pena Lefebvre, Paloma Garcia, Rodriguez Rubio, Silvia, Valero Exposito, Marta, Sibilia, Jean, Chatelus, Emmanuel, Gottenberg, Jacques Eric, Chifflot, Helene, Litinsky, Ira, Emery, Paul, Buch, Maya, Del Galdo, Francesco, Venalis, Algirdas, Butrimiene, Irena, Venalis, Paulius, Rugiene, Rita, Karpec, Diana, Saketkoo, Lesley Ann, Lasky, Joseph A, Kerzberg, Eduardo, Montoya, Fabiana, Cosentino, Vanesa, Limonta, Massimiliano, Brucato, Antonio Luca, Lupi, Elide, Rosner, Itzhak, Rozenbaum, Michael, Slobodin, Gleb, Boulman, Nina, Rimar, Doron, Couto, Maura, Spertini, Francois, Ribi, Camillo, Buss, Guillaume, Kahl, Sarah, Hsu, Vivien M, Chen, Fei, McCloskey, Deborah, Malveaux, Halina, Pasquali, Jean Louis, Martin, Thierry, Gorse, Audrey, Guffroy, Aurelien, Poindron, Vincent, EUSTAR Collaborators, Guiducci, S., Walker, U., Kyburz, D., Lapadula, G., Iannone, F., Maurer, B., Jordan, S., Becvar, R., Sierakowsky, S., Kowal Bielecka, O., Cutolo, M., Sulli, A., Valentini, G., Cuomo, G., Siegert, E., Rednic, S., Nicoara, I., Kahan, A., Vlachoyiannopoulos, P., Montecucco, C., Caporali, R., Stork, J., Inanc, M., Carreira, P.E., Novak, S., Czirják, L., Varju, C., Chizzolini, C., Kucharz, E.J., Kotulska, A., Kopec-Medrek, M., Widuchowska, M., Rozman, B., Mallia, C., Coleiro, B., Gabrielli, A., Farge, D., Wu, C., Marjanovic, Z., Faivre, H., Hij, D., Dhamadi, R., Airò, P., Hesselstrand, R., Wollheim, F., Wuttge, D.M., Andréasson, K., Martinovic, D., Balbir-Gurman, A., Braun-Moscovici, Y., Trotta, F., Lo Monaco, A., Hunzelmann, N., Pellerito, R., Mauriziano, O., Maria Bambara, L., Caramaschi, P., Morovic-Vergles, J., Black, C., Damjanov, N., Henes, J., Ortiz Santamaria, V., Heitmann, S., Krasowska, D., Seidel, M., Hasler, P., Burkhardt, H., Himsel, A., Bajocchi, G., Maria Nuova, A.S., João Salvador, M., Pereira Da Silva, J.A., Stamenkovic, B., Stankovic, A., Francesco Selmi, C., De Santis, M., Marasini, B., Tikly, M., Ananieva, L.P., Denisov, L.N., Müller-Ladner, U., Frerix, M., Tarner, I., Scorza, R., Puppo, F., Engelhart, M., Strauss, G., Nielsen, H., Damgaard, K., Szücs, G., Szamosi, S., Zea Mendoza, A., de la Puente, C., Sifuentes Giraldo, W.A., Midtvedt, Ø., Reiseter, S., Garen, T., Valesini, G., Riccieri, V., Maria Ionescu, R., Opris, D., Groseanu, L., Wigley, F.M., Sfrent Cornateanu, R., Ionitescu, R., Maria Gherghe, A., Soare, A., Gorga, M., Bojinca, M., Mihai, C., Milicescu, M., Sunderkötter, C., Kuhn, A., Sandorfi, N., Schett, G., Distler, J.H., Beyer, C., Meroni, P., Ingegnoli, F., Mouthon, L., De Keyser, F., Smith, V., Paolo Cantatore, F., Corrado, A., Ullman, S., Iversen, L., Alberto von Mühlen, C., Marilu Bohn, J., Scussel Lonzetti, L., Rosa Pozzi, M., Eyerich, K., Hein, R., Knott, E., Wiland, P., Szmyrka-Kaczmarek, M., Sokolik, R., Morgiel, E., Madej, M., Houssiau, F.A., Jose Alegre-Sancho, J., Krummel-Lorenz, B., Saar, P., Aringer, M., Günther, C., Westhovens, R., de Langhe, E., Lenaerts, J., Anic, B., Baresic, M., Mayer, M., Üprus, M., Otsa, K., Yavuz, S., Granel, B., Cezar Radominski, S., de Souza Müller, C., Azevedo, V.F., Jimenez, S., Busquets, J., Agachi, S., Groppa, L., Chiaburu, L., Russu, E., Popa, S., Zenone, T., Pileckyte, M., Stebbings, S., Highton, J., Mathieu, A., Vacca, A., Sampaio-Barros, P.D., Yoshinari, N.H., Marangoni, R.G., Martin, P., Fuocco, L., Stamp, L., Chapman, P., O'Donnell, J., Solanki, K., Doube, A., Veale, D., O'Rourke, M., Loyo, E., Li, M., Abdel Atty Mohamed, W.A., Rosato, E., Amoroso, A., Gigante, A., Oksel, F., Yargucu, F., Tanaseanu, C.M., Popescu, M., Dumitrascu, A., Tiglea, I., Foti, R., Chirieac, R., Ancuta, C., Furst, D.E., Villiger, P., Adler, S., van Laar, J., Kayser, C., Eduardo C, A.L., Fathi, N., Hassanien, M., de la Peña Lefebvre, P.G., Rodriguez Rubio, S., Valero Exposito, M., Sibilia, J., Chatelus, E., Gottenberg, J.E., Chifflot, H., Litinsky, I., Emery, P., Buch, M., Del Galdo, F., Venalis, A., Butrimiene, I., Venalis, P., Rugiene, R., Karpec, D., Ann Saketkoo, L., Lasky, J.A., Kerzberg, E., Montoya, F., Cosentino, V., Limonta, M., Luca Brucato, A., Lupi, E., Rosner, I., Rozenbaum, M., Slobodin, G., Boulman, N., Rimar, D., Couto, M., Spertini, F., Ribi, C., Buss, G., Kahl, S., Hsu, V.M., Chen, F., McCloskey, D., Malveaux, H., Louis Pasquali, J., Martin, T., Gorse, A., Guffroy, A., Poindron, V., and Chizzolini, Carlo

Subjects
0301 basic medicine, Male, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences, Databases, Factual, systemic sclerosis, SUBSETS, Disease, Severity of Illness Index, Scleroderma, DISEASE, 0302 clinical medicine, Medicine and Health Sciences, Immunology and Allergy, Cluster Analysis, CRITERIA, Prospective Studies, Prospective cohort study, skin and connective tissue diseases, integumentary system, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti, Adult, Aged, Autoantibodies/blood, Europe/epidemiology, Female, Humans, Middle Aged, Phenotype, Prognosis, Scleroderma, Diffuse/blood, Scleroderma, Diffuse/epidemiology, Scleroderma, Diffuse/pathology, Scleroderma, Limited/blood, Scleroderma, Limited/epidemiology, Scleroderma, Limited/pathology, Scleroderma, Systemic/blood, Scleroderma, Systemic/epidemiology, Scleroderma, Systemic/pathology, Connective tissue disease, ddc, Europe, MANIFESTATIONS, Cohort, Life Sciences & Biomedicine, medicine.medical_specialty, Immunology, PROFILE, CLASSIFICATION, 03 medical and health sciences, Rheumatology, Scleroderma, Limited, Internal medicine, Severity of illness, medicine, Autoantibodies, 030203 arthritis & rheumatology, Science & Technology, Scleroderma, Systemic, business.industry, Autoantibody, Systemic sclerosis (SSc), medicine.disease, 030104 developmental biology, Scleroderma, Diffuse, business
Abstract

OBJECTIVE: Systemic sclerosis (SSc) is a heterogeneous connective tissue disease that is typically subdivided into limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc) depending on the extent of skin involvement. This subclassification may not capture the entire variability of clinical phenotypes. The European Scleroderma Trials and Research (EUSTAR) database includes data on a prospective cohort of SSc patients from 122 European referral centers. This study was undertaken to perform a cluster analysis of EUSTAR data to distinguish and characterize homogeneous phenotypes without any a priori assumptions, and to examine survival among the clusters obtained. METHODS: A total of 11,318 patients were registered in the EUSTAR database, and 6,927 were included in the study. Twenty-four clinical and serologic variables were used for clustering. RESULTS: Clustering analyses provided a first delineation of 2 clusters showing moderate stability. In an exploratory attempt, we further characterized 6 homogeneous groups that differed with regard to their clinical features, autoantibody profile, and mortality. Some groups resembled usual dcSSc or lcSSc prototypes, but others exhibited unique features, such as a majority of lcSSc patients with a high rate of visceral damage and antitopoisomerase antibodies. Prognosis varied among groups and the presence of organ damage markedly impacted survival regardless of cutaneous involvement. CONCLUSION: Our findings suggest that restricting subsets of SSc patients to only those based on cutaneous involvement may not capture the complete heterogeneity of the disease. Organ damage and antibody profile should be taken into consideration when individuating homogeneous groups of patients with a distinct prognosis. ispartof: ARTHRITIS & RHEUMATOLOGY vol:71 issue:9 pages:1553-1570 ispartof: location:United States status: published

Published
2019

22. The development of candidate composite disease activity and responder indices for psoriatic arthritis (GRACE project)

Author

Helliwell, Philip S, primary, FitzGerald, Oliver, additional, Fransen, Jaap, additional, Gladman, Dafna D, additional, Kreuger, Gerald G, additional, Callis-Duffin, Kristina, additional, McHugh, Neil, additional, Mease, Philip J, additional, Strand, Vibeke, additional, Waxman, Robin, additional, Azevedo, Valderilio Feijo, additional, Beltran Ostos, Adriana, additional, Carneiro, Sueli, additional, Cauli, Alberto, additional, Espinoza, Luis R, additional, Flynn, John A, additional, Hassan, Nada, additional, Healy, Paul, additional, Kerzberg, Eduardo Mario, additional, Lee, Yun Jong, additional, Lubrano, Ennio, additional, Marchesoni, Antonio, additional, Marzo-Ortega, Helena, additional, Porru, Giovanni, additional, Moreta, Elvia G, additional, Nash, Peter, additional, Raffayova, Helena, additional, Ranza, Roberto, additional, Raychaudhuri, Siba P, additional, Roussou, Euthalia, additional, Scarpa, Raphael, additional, Song, Yeong Wook, additional, Soriano, Enrique R, additional, Tak, Paul P, additional, Ujfalussy, Ilona, additional, de Vlam, Kurt, additional, and Walsh, Jessica A, additional

Published
2012
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25. Tradução e validação do escore indiano de atividade clínica da arterite de Takayasu em língua portuguesa

Author

Fritsch, Scheila, Souza, Alexandre Wagner Silva de, Universidade Federal do Paraná. Setor de Ciências da Saúde. Programa de Pós-Graduação em Medicina Interna, and Azevedo, Valderilio Feijo

Subjects
Arterite de Takayasu, Clínica médica
Abstract

Orientador : Prof. Dr. Valderílio Feijó Azevedo Coorientador : Prof. Dr. Alexandre Wagner Silva de Souza Dissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências da Saúde, Programa de Pós-Graduação em Medicina Interna. Defesa : Curitiba, 07/08/2017 Inclui referências : f. 45-49 Resumo: Introdução: A Arterite de Takayasu é uma vasculite sistêmica que ocasiona inflamação parietal de grandes artérias. Em 2010, surgiu um questionário clínico com objetivo de melhorar a avaliação clínica e definições terapêuticas, o ITAS2010 - Indian Takayasu's Arteritis Activity Score. Objetivos: Traduzir o ITAS2010 para língua portuguesa e validar esta versão para seu uso no Brasil. Métodos: Realizou-se estudo observacional transversal e prospectivo de pacientes portadores de Arterite de Takayasu, por meio do questionário ITAS2010 traduzido para língua portuguesa pelo método de Beaton et al. O questionário foi aplicado a vinte e sete pacientes. Cada paciente foi submetido a três avaliações por dois reumatologistas independentes. Para se avaliar a reprodutibilidade interobservador, as avaliações foram realizadas no mesmo dia, com intervalo de aproximadamente uma hora. Um dos reumatologistas realizou uma segunda avaliação de cada paciente, com intervalo de 7 a 14 dias, para se avaliar a reprodutibilidade intraobservador. Resultados: Houve alta correlação interobservador (entre X1 e R) tanto pelo coeficiente de Pearson (r=0,916) quanto pelo coeficiente de correlação intraclasse (CCIC=0,918), com alto grau de confiabilidade (demonstrado pelo estreito intervalo de confiança - IC= 0,828-0,962). A correlação intraobservador (entre X1 e X2) foi apenas moderada: coeficiente de Pearson de 0,633 e CCIC de 0,594, IC 0,292-0,790. Apenas dois pacientes foram classificados como ativos pelos critérios do NIH para vasculite de grandes vasos. Quanto à avaliação global do médico (PGA), não houve diferença de ITAS2010 entre os três grupos (ativo, baixa atividade ou inativo). Discussão: A correlação entre as avaliações de dois observadores foi alta, compatível com o esperado, demonstrando a reprodutibilidade do ITAS2010. A correlação entre as avaliações do mesmo observador em ocasiões diferentes foi moderada, pelos possíveis vieses de memória dos pacientes e diferença na aferição dos dados por parte do pesquisador. O número reduzido de pacientes pode ter contribuído para este resultado. Conclusão: Esta versão traduzida do ITAS2010 para língua portuguesa é válida e reprodutível. Deve ser incluído na avaliação rotineira de pacientes com Takayasu, pois pode facilitar decisões terapêuticas. Palavras-chave: Arterite de Takayasu. Atividade de doença. ITAS2010. Abstract:Introduction: Takayasu's Arteritis is a systemic vasculitis that causes parietal inflammation of large arteries. In 2010, a clinical questionnaire was developed to improve clinical assessment and therapeutic settings, the ITAS2010 - Indian Takayasu's Arteritis Activity Score. Objective: Translate ITAS2010 into brazillian portuguese and its validation in a subset of brazillian patients. Methods: A cross-sectional and prospective observational study of Takayasu's Arteritis patients was performed using a portuguese ITAS2010 version. This version was created through the method of Beaton et al. The questionnaire was applied to twenty-seven patients. Each patient was submitted to three evaluations by two independent rheumatologists. To assess inter-observer reproducibility, the evaluations were performed on the same day, with an interval of approximately one hour (X1 and R). One of the rheumatologists performed a second evaluation of each patient (X2), ranging from 7 to 14 days, to evaluate the intra-observer reproducibility. Results: There was high inter-observer ITAS2010 correlation (between X1 and R) obtained by Pearson coefficient (r= 0.916) and intra-class correlation coefficient (ICC= 0.918), with a high reliability coefficient, given by the narrow confidence interval (CI= 0.828-0.962). Intra-observer ITAS2010 correlation (between X1 and X2) was moderate, given by Pearson coefficient of 0.633 and ICC of 0.594, (CI= 0.292-0.790). Only two patients were classified active by the NIH criteria for large vessel vasculitis. Regarding physician's global assessment (PGA), there was no ITAS2010 difference between the three groups (active, grumbling disease or inactive). Discussion: Inter-observer correlation was high, as expected, which demonstrates ITAS2010 reprodutibility. The intra-observer correlation was only moderate, which can be explained by memory bias of patients in different days and by differences in measurement of clinical data by the researcher. The reduced number of patients may have contributed to this result. Conclusion: The brazillian portuguese version of ITAS2010 is valid and reproducible between different clinicians. It should be included in routine assessment of Takayasu patients, as it may facilitate therapeutic decisions. Keywords: Takayasu's Arteritis. Disease activity. ITAS2010

Published
2017

26. Efeito de lipossomos peguilados e constituídos de fósfatidilserina na artrite experimental crônica

Author

Urbano, Paulo César Martins, Soccol, Vanete Thomaz, Azevedo, Valderilio Feijo, and Universidade Federal do Paraná. Setor de Tecnologia. Programa de Pós-Graduação em Engenharia de Bioprocessos e Biotecnologia

Subjects
Dissertações
Abstract

Resumo: A Artrite reumatoide (AR) é uma doença auto-imune inflamatória, que acomete as articulações, promovendo acúmulo de células na região sinovial, danos na cartilagem e formação de pannus. Nos últimos anos o emprego de lipossomos constituídos de fosfatidilserina (LFS), demonstrou reduzir a inflamação em modelos animais de artrite aguda, supostamente por mimetizar o processo da apoptose. Esta nova alternativa surge como possível terapia da AR. Objetivo: A pesquisa teve por objetivo avaliar a eficácia de lipossomos peguilados e constituídos de FS (LPeg-FS) em modelo de artrite experimental crônica, utilizando camundongos com artrite induzida por colágeno bovino tipo II (CIA) e sua ação imunomoduladora em in vitro. Método: A artrite foi induzida nos camundongos (n=24) por CIA no dia zero. No 18° dia, após a imunização, os animais receberam o booster. O tratamento iniciou-se no mesmo dia do booster, com administrações subcutâneas (s.c.) diárias no período de 20 dias. Foram constituídos quatro grupos experimentais; grupo 1 sem tratamento - solução salina (n=6), grupo 2 tratado com LPeg-FS numa concentração de 5 mg/kg (n=6), grupo 3 tratado com 10 mg/kg (n=6) e grupo 4 tratado com 15 mg/kg (n=6). Análise da oxidação de LPEg-FS por CLAE, escore clínico de gravidade, incidência da doença, peso dos animais e dosagens de citocinas das articulações dos joelhos dos animais foram avaliadas. Para análise da imunomodulação de LPeg-FS, foi realizado um estudo in vitro com culturas de macrófagos estimulados com lipopolissacarídeo (LPS)/Acetato de miristato de forbol (PMA). Para esse experimento foram formados seis grupos; cultura sem tratamento (G1), PBS (G2), 100 ?M de LPeg-FS (G3), LPS/PMA (G4), LPS/PMA e PBS (G5) e LPS/PMA e LPeg-FS (G6). Resultados: LPeg-Fs nas doses de 10 mg/kg e 15 mg/kg não foi eficiente em reduzir o escore da doença nos animais. No entanto, o grupo LPeg-FS 5 mg/kg não apresentou o estágio mais avançado da doença, em comparação ao controle. Nas amostras das articulações dos joelhos coletados após o tratamento, os grupos LPEg-FS 15 mg/kg e 10 mg/kg, reduziram significativamente IL-6, IL-2, IFN-? e TNF-?, respectivamente, mesmo apresentando um elevado escore clínico. Os experimentos não apresentaram uma relação entre a diminuição dessas citocinas com TGF-?1 no estudo in vivo. A Incidência da doença e peso dos animais não foram afetadas pelo tratamento. Na concentração 100 ?M de LPeg-FS não se verificou a redução da inflamação instaurada por LPS/PMA no estudo in vitro. A presença de produtos oxidados na solução de LPeg-FS foi observada. Conclusão: A resolução da doença in vivo e do processo inflamatório in vitro não foi observada. No entanto, LPeg-FS demonstrou regular a produção de TNF-? (LPeg-FS 10 mg/mL) e IL-6, IL-2, IFN-? (LPeg-FS 15 mg/kg) nas articulações dos joelhos dos animais acometidos pela doença, por uma via de ação ainda desconhecida, aparentemente não relacionada com TGF-?1 e IL-10. Porém, tal efeito não repercutiu na melhora clínica dos animais. Novos estudos empregando novas dosagens e vias de administração alternativas, precisam ser realizados para avaliar a intervenção terapêutica de LPeg-FS em modelo experimental CIA.

Published
2013

27. Microalbuminuria e estudo morfologico renal na avaliaçao de pacientes com lupus eritematoso sistemico sem comprometimento renal clinico-laboratorial

Author

Almeida, Renato Valente de, Azevedo, Valderilio Feijo, Universidade Federal do Paraná. Setor de Ciências da Saúde. Programa de Pós-Graduação em Medicina Interna, and Carvalho, Jose Gastão Rocha de, 1945

Subjects
Lupus eritematoso
Abstract

Orientador : José Gastao Rocha de Carvalho Co-orientador : Valderílio Feijó Azevedo Dissertaçao (mestrado) - Universidade Federal do Paraná, Setor de Ciencias da Saúde, Programa de Pós-Graduação em Medicina Interna Resumo: A fim de se caracterizar a nefrite lúpica incipiente, foram analisadas suas manifestações clínicas, dosada a microalbuminúria (jjALB) e realizada biópsia renal em 30 pacientes portadores de lúpus eritematoso sistêmico (LES) sem evidência clínico-laboratorial de comprometimento renal. As biópsias renais foram classificadas de acordo com a classes propostas pela OMS. Quinze pacientes (50%) apresentaram glomerulonefrite mesangial (GNM) classe llb; 12 apresentaram GNM classe lia e 3 não apresentaram alteração na microscopia óptica (MO) ou na imunofluorescência (IF) (classe I). Nenhum paciente apresentou alteração compatível com glomerulonefrite proliferativa ou membranosa. Depósitos fluorescentes anti-lgM foram observados em 83% das biópsias renais, associados com depósitos menos intensos de IgG, IgA e C3. Pacientes com GNM classe Ha tinham média de idade de 36,3 anos e duração da doença de 3,25 anos; sua média da juALB foi de 9,35^/g/min. Pacientes com GNM classe llb tinham menor média de idade quando comparados aos da classe tia (26,04 anos vs. 36,3 anos) (p

Published
1998

28. Vaccination Recommendations for Adults With Autoimmune Inflammatory Rheumatic Diseases in Latin America.

Author

Brenol CV, Azevedo VF, Bonvehi PE, Coral-Alvarado PX, Granados J, Muñoz-Louis R, Pineda C, and Vizzotti C

Subjects
Adult, Autoimmune Diseases epidemiology, Humans, Latin America epidemiology, Rheumatic Diseases epidemiology, Autoimmune Diseases immunology, Rheumatic Diseases immunology, Vaccination
Abstract

Background/objective: Patients with autoimmune inflammatory rheumatic diseases (AIRDs) are at increased risk of contracting severe infections and suffering complications, particularly when they are receiving immunomodulating therapy. Vaccination is an important means to prevent many potential infections and thereby reduce the morbidity and mortality associated with AIRD. The purpose of this consensus document is to provide health care professionals with recommendations for the vaccination of AIRD patients who reside in Latin America. The recommendations were developed by an expert committee from the region based on a review of the literature and their clinical experience., Methods: The Americas Health Foundation (AHF) used PubMed and EMBASE to identify clinicians and scientists with an academic or hospital affiliation and who had published in the field of adult vaccination and rheumatic diseases since 2010. As a result of this effort, AHF convened an 8-member panel of clinical and scientific experts from Latin America. Both the AHF and panel members conducted a careful literature review to identify relevant publications in the areas of adult vaccination and rheumatology, and the sum of the articles identified was provided to the entire panel. Prior to the conference, panelists were each asked to prepare a written response to a salient issue on the subject, identified by AHF., Results and Conclusions: During the conference, each response was edited by the entire group, through numerous drafts and rounds of discussion until a complete consensus on vaccination recommendations for adult patients with AIRDs was obtained, including 7 key recommendations.

Published
2018
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29. The Experience with Biosimilars of Infliximab in Rheumatic Diseases.

Author

Azevedo VF, Kos IA, and Ariello L

Subjects
Humans, Biosimilar Pharmaceuticals therapeutic use, Infliximab therapeutic use, Rheumatic Diseases drug therapy
Abstract

Background: Infliximab biosimilars are the first biosimilars of monoclonal antibodies approved by the main regulatory agencies. Up to the present day, two infliximab biosimilars have been approved: CT-P13 (Celltrion), and SB2 (Biogen), but other companies have been developing candidate infliximab biosimilars that are on clinical trials: PF 06438179 (Pfizer), the ABP710 (bioCentury/Amgen) the BCD055 (JSC Biocad Russica) and BOW015 (Epirus)., Methods: We have made a literature search in MedLine database using the key words [Infliximab] and [biosimilars] and [rheumatic diseases] and [rheumatisms]. We have also made a search in the clinicaltrials.org website., Conclusions: Clinical data published so far have provided important evidence on long-term efficacy and safety, immunogenicity and switching, supporting the use of CT-P13 and SB2 for the treatment of rheumatic diseases. In addition, the European experience has proved the economic advantages of the incorporation of infliximab biosimilars in clinical practice. Despite the widespread use of infliximab biosimilars there is still a lack of data regarding interchangeability between reference products and biosimilars., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)

Published
2017
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