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1,381 results on '"Azarpira, Negar"'

15. From Hair to the Brain: The Short-Term Therapeutic Potential of Human Hair Follicle-Derived Stem Cells and Their Conditioned Medium in a Rat Model of Stroke

Author

Karimi-Haghighi, Saeideh, Pandamooz, Sareh, Jurek, Benjamin, Fattahi, Sadegh, Safari, Anahid, Azarpira, Negar, Dianatpour, Mehdi, Hooshmandi, Etrat, Bayat, Mahnaz, Owjfard, Maryam, Zafarmand, Seyedeh Shaghayegh, Mostaghel, Mandana, Mousavi, Seyedeh Maryam, Jashire Nezhad, Nahid, Eraghi, Vida, Fadakar, Nima, Rahimi Jaberi, Abbas, Garcia-Esperon, Carlos, Spratt, Neil, Levi, Christopher, Salehi, Mohammad Saied, and Borhani-Haghighi, Afshin

Published
2023
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19. Combined use of hair follicle stem cells and CEPO (carbamylated erythropoietin)-Fc in a rat model of chronic cerebral hypoperfusion: A behavioral, electrophysiological, and molecular study

Author

Hooshmandi, Etrat, Akbari, Somayeh, Pandamooz, Sareh, Ghobadi, Mojtaba, Ghasemi, Rasoul, Maghsoudi, Nader, Rai, Sachchida Nand, Borhani-Haghighi, Afshin, Salehi, Mohammad Saied, Azarpira, Negar, YousefiNejad, Amirhossein, Haghani, Masoud, and Bayat, Mahnaz

Published
2023
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24. Short-term beneficial effects of human dental pulp stem cells and their secretome in a rat model of mild ischemic stroke

Author

Jashire Nezhad, Nahid, Safari, Anahid, Namavar, Mohammad Reza, Nami, Mohammad, Karimi-Haghighi, Saeideh, Pandamooz, Sareh, Dianatpour, Mehdi, Azarpira, Negar, Khodabandeh, Zahra, Zare, Shahrokh, Hooshmandi, Etrat, Bayat, Mahnaz, Owjfard, Maryam, Zafarmand, Seyedeh Shaghayegh, Fadakar, Nima, Jaberi, Abbas Rahimi, Salehi, Mohammad Saied, and Borhani-Haghighi, Afshin

Published
2023
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26. Taurine mitigates the development of pulmonary inflammation, oxidative stress, and histopathological alterations in a rat model of bile duct ligation

Author

Ommati, Mohammad Mehdi, Mobasheri, Ali, Ma, Yanqin, Xu, Dongmei, Tang, Zhongwei, Manthari, Ram Kumar, Abdoli, Narges, Azarpira, Negar, Lu, Yu, Sadeghian, Issa, Mousavifaraz, Abolghasem, Nadgaran, Ali, Nikoozadeh, Ahmad, Mazloomi, Sahra, Mehrabani, Pooria Sayar, Rezaei, Mohammad, Xin, Hu, Mingyu, Yang, Niknahad, Hossein, and Heidari, Reza

Published
2022
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28. Comparing the healing properties of intra-articular injection of human dental pulp stem cells and cell-free-secretome on induced knee osteoarthritis in male rats

Author

Nowzari, Fariborz, Zare, Masoud, Tanideh, Nader, Meimandi-Parizi, Abdolhamid, Kavousi, Shahin, Saneian, Seyed Mojtaba, Zare, Shahrokh, Koohi-Hosseinabadi, Omid, Ghaemmaghami, Parvin, Dehghanian, Amirreza, Daneshi, Sajad, Azarpira, Negar, Aliabadi, Arvin, Samimi, Kiana, Irajie, Cambyz, and Iraji, Aida

Published
2023
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31. Circulating lncRNAs HOTTIP and HOTAIR as Potential Biomarkers in Crigler-Najjar Syndrome: A Preliminary Report from Shiraz Liver Transplant Research Center

Author

Motazedian, Nasrin, primary, Mokhtari, Masoud, additional, Azarpira, Negar, additional, Falamarzi, Kimia, additional, Mohammadi, Mohsen, additional, Dehghani, Seyed Mohsen, additional, Pourjafar, Sarina, additional, Ataollahi, Maryam, additional, Esfandiari, Elaheh, additional, Hossein-Aghdaie, Mahdokht, additional, Malekhosseini, Seyed Ali, additional, Kazemi, Tayebeh, additional, and Dara, Mahintaj, additional

Published
2024
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47. Enhancing bone regeneration: Unleashing the potential of magnetic nanoparticles in a microtissue model.

Author

Dousti, Maryam, Parsa, Shima, Sani, Farnaz, Bagherzadeh, Elham, Zamanzadeh, Zahra, Dara, Mahintaj, Sani, Mahsa, and Azarpira, Negar

Subjects
IRON oxide nanoparticles, BONE regeneration, MAGNETIC nanoparticles, BIOMIMETICS, UMBILICAL veins, SUPERPARAMAGNETIC materials
Abstract

Bone tissue engineering addresses the limitations of autologous resources and the risk of allograft disease transmission in bone diseases. In this regard, engineered three‐dimensional (3D) models emerge as biomimetic alternatives to natural tissues, replicating intracellular communication. Moreover, the unique properties of super‐paramagnetic iron oxide nanoparticles (SPIONs) were shown to promote bone regeneration via enhanced osteogenesis and angiogenesis in bone models. This study aimed to investigate the effects of SPION on both osteogenesis and angiogenesis and characterized a co‐culture of Human umbilical vein endothelial cells (HUVEC) and MG‐63 cells as a model of bone microtissue. HUVECs: MG‐63s with a ratio of 4:1 demonstrated the best results among other cell ratios, and 50 μg/mL of SPION was the optimum concentration for maximum survival, cell migration and mineralization. In addition, the data from gene expression illustrated that the expression of osteogenesis‐related genes, including osteopontin, osteocalcin, alkaline phosphatase, and collagen‐I, as well as the expression of the angiogenesis‐related marker, CD‐31, and the tube formation, is significantly elevated when the 50 μg/mL concentration of SPION is applied to the microtissue samples. SPION application in a designed 3D bone microtissue model involving a co‐culture of osteoblast and endothelial cells resulted in increased expression of specific markers related to angiogenesis and osteogenesis. This includes the design of a novel biomimetic model to boost blood compatibility and biocompatibility of primary materials while promoting osteogenic activity in microtissue bone models. Moreover, this can improve interaction with surrounding tissues and broaden the knowledge to promote superior‐performance implants, preventing device failure. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Droplet-based microfluidics: an efficient high-throughput portable system for cell encapsulation.

Author

Dortaj, Hengameh, Amani, Ali Mohammad, Tayebi, Lobat, Azarpira, Negar, Ghasemi Toudeshkchouei, Mahtab, Hassanpour-Dehnavi, Ashraf, Karami, Neda, Abbasi, Milad, Najafian-Najafabadi, Atefeh, Zarei Behjani, Zeinab, and Vaez, Ahmad

Subjects
DRUG discovery, TISSUE engineering, REGENERATIVE medicine, CELL differentiation, BIOPOLYMERS
Abstract

One of the goals of tissue engineering and regenerative medicine is restoring primary living tissue function by manufacturing a 3D microenvironment. One of the main challenges is protecting implanted non-autologous cells or tissues from the host immune system. Cell encapsulation has emerged as a promising technique for this purpose. It involves entrapping cells in biocompatible and semi-permeable microcarriers made from natural or synthetic polymers that regulate the release of cellular secretions. In recent years, droplet-based microfluidic systems have emerged as powerful tools for cell encapsulation in tissue engineering and regenerative medicine. These systems offer precise control over droplet size, composition, and functionality, allowing for creating of microenvironments that closely mimic native tissue. Droplet-based microfluidic systems have extensive applications in biotechnology, medical diagnosis, and drug discovery. This review summarises the recent developments in droplet-based microfluidic systems and cell encapsulation techniques, as well as their applications, advantages, and challenges in biology and medicine. The integration of these technologies has the potential to revolutionise tissue engineering and regenerative medicine by providing a precise and controlled microenvironment for cell growth and differentiation. By overcoming the immune system's challenges and enabling the release of cellular secretions, these technologies hold great promise for the future of regenerative medicine. [ABSTRACT FROM AUTHOR]

Published
2024
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49. The effects of simvastatin‐loaded nanoliposomes on human multilineage liver fibrosis microtissue.

Author

Parsa, Shima, Dousti, Maryam, Mohammadi, Nasim, Abedanzadeh, Mozhgan, Dehdari Ebrahimi, Niloofar, Dara, Mahintaj, Sani, Mahsa, Nekouee, Muhammad, Abolmaali, Samira Sadat, Sani, Farnaz, and Azarpira, Negar

Subjects
HEPATIC fibrosis, NON-alcoholic fatty liver disease, LIVER cells, OLEIC acid, KRUPPEL-like factors
Abstract

In this in vitro study, for the first time, we evaluate the effects of simvastatin‐loaded liposome nanoparticles (SIM‐LipoNPs) treatment on fibrosis‐induced liver microtissues, as simvastatin (SIM) has shown potential benefits in the non‐alcoholic fatty liver disease process. We developed multicellular liver microtissues composed of hepatic stellate cells, hepatoblastoma cells and human umbilical vein endothelial cells. The microtissues were supplemented with a combination of palmitic acid and oleic acid to develop fibrosis models. Subsequently, various groups of microtissues were exposed to SIM and SIM‐LipoNPs at doses of 5 and 10 mg/mL. The effectiveness of the treatments was evaluated by analysing cell viability, production of reactive oxygen species (ROS) and nitric oxide (NO), the expression of Kruppel‐like factor (KLF) 2, and pro‐inflammatory cytokines (interleukin(IL)‐1 α, IL‐1 β, IL‐6 and tumour necrosis factor‐α), and the expression of collagen I. Our results indicated that SIM‐LipoNPs application showed promising results. SIM‐LipoNPs effectively amplified the SIM‐klf2‐NO pathway at a lower dosage compatible with a high dosage of free SIM, which also led to reduced oxidative stress by decreasing ROS levels. SIM‐LipoNPs administration also resulted in a significant reduction in pro‐inflammatory cytokines and Collagen I mRNA levels, as a marker of fibrosis. In conclusion, our study highlights the considerable therapeutic potential of using SIM‐LipoNPs to prevent liver fibrosis progress, underscoring the remarkable properties of SIM‐LipoNPs in activating the KLF2‐NO pathway and anti‐oxidative and anti‐inflammatory response. [ABSTRACT FROM AUTHOR]

Published
2024
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