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Background: Meningitis is one of the serious and dangerous infections in the infancy and childhood and rapid diagnosis of meningococcal disease is important, especially in infants. C-reactive protein (CRP) is a protein found in blood and is an acute phase protein. CRP sensitive reactive that used for diagnosis of infection. This study conducted to assessment of the relationship between cerebrospinal fluid C-reactive protein, and neonatal meningitis, as well as diagnostic value of test. Methods: Forty nine hospitalized infant that suspected to meningitis were enrolled in this analytic cross sectional research via non probable accessible sampling. 28 patients (52.7%) of all the patients were male and 21 patients (42.8%) were female. The average age of the patients was 22.6±11.88 days. Data from clinical examinations and laboratory tests entered in a questionnaire and all of samples divided in two bacterial (septic) and non-bactria (aseptic) meningitis group. All data including cerebrospinal fluid CRP of newborns were statistically analyzed. Results: In total, the mean and standard deviation of age was 22.6±11.88 days. 57.2% of infants were male and 42.8% were female. In total, 40.82% of infants were diagnosed with septic meningitis. There was no significant difference between septic and aseptic groups in terms of sex (P= 1.00) also in terms of age (P= 0.1). The mean and standard deviation of CRP level in septic meningitis group was 0.95±0.68 mg/L and in aseptic group was 0.16±0.36 mg/L. The CRP level difference in septic meningitis group compare with aseptic group was statistically significant (P

Background: The main cause of toxic shock is TSST-1 toxin which is produced by S. aureus. Finding of TSST-1 toxin in burnt children is very important to prevent TSS and its consequences. Methods: The aim of this study was to investigate the presence of gene encoding TSST-1 toxin in wound specimens by PCR. In this case-control study, 90 children who were admitted to the burn unit, were divided in two groups of 45 patients, namely febrile (cases group) and non-febrile (control group). Samplings were done from the burn wounds and were tested by PCR with specific primers of tstH gene. Finally, all data including demographic characteristics, percentage of burnt surface severity and the PCR results were analyzed, statistically. Results: The positive PCR results indicated the expression of tstH gene in 37.7% of the febrile children and 11.1% of the non-febrile children with a statistically significant difference (p

Introduction & Objective: The role and frequency of HHV-6 and HHV-7 in central nervous system (CNS) diseases of our children are unclear. The aim of this study was to search for the presence of HHV-6 & HHV-7 DNA-s in CSF samples in children with meningoencephalitis. Materials & Methods: In a cross- sectional study (2007-2009) done in the pediatric ward in Hazrat Rasoul hospital, Tehran ,Iran ,150 CSF samples were obtained from children with meningoencephalitis. The conventional and BACTEC Ped Plus medium Latex agglutination tests and in some cases bacterial PCR assay were used. We examined the DNA-s of HHV-6 & HHV-6 quantitavively by real time - PCR in the CSF samples. Results: Cases were 91 (60.7%) male 59 (39.3%) female 1-180 months old. Fever (>38.5° C) was observed in 74% irritability in 70% and convulsion in 53% of cases. All herpes viruses were detected in 18 (12%) cases, HHV-6 DNA was detected in 6 cases and HHV-7 DNA detected in 2 cases with no correlation with age, sex and clinical signs. Conclusion: HHV-6 & HHV-7 were found in nearly 6% of all studied cases. HHV-6 was slightly more frequent than HHV-7 and its incidence is lower .Our data indicates that herpes viruses are not uncommon causes in children with meningoencephalitis. Our findings are different from those of previous studies perhaps due to the epidemiologic and geographic variations (differences in methods and age groups should be added to this).