Objective: The reasons that some of these studies have offered for aerobic training's lack of tangible effect on the level of angiogenesis, are subjects' readiness and the conditions of their diseases, while others have detected the intensity and the frequency of doing the aerobic trainings as the factors preventing the effectiveness of them on the level of angiogenesis. Thus, the present study studied the effects of taking interval and continuous aerobic trainings on the degrees of angiogenesis and nitric oxide. Materials and Methods: Sixty eligible old men in Kahrizak nursing home among volunteers were selected and studied in three groups (Continuous, Interval and Control). First, the initial blood samples were gathered to record of serum WEGF by ELISA kit. In the second stage NO in saliva were measured by conversion of nitrate to nitrite and by Griess reaction. After the 48 hours, experimental group in both continuous and interval carried out training for 6 weeks and the control group continued their daily activities. Post-test data measured and recorded in the same conditions with the pre-test. Obtained data were analyzed by using one-way ANOVA, Scheffe post hoc and dependent T-test. Results: The results showed that WEGF serum and salivary NO levels after performing the aerobic training to both continuous and interval methods was not any significantly different (P>0.05). However, the percentage change recorded data for the experimental group than in the control group despite the lack of significant difference of nearly a significant increase in the WEGF serum and saliva levels of NO were observed (No: Continuous and Interval≈ 0/05 increase, Control: 0/01 increase, VEGF: Continuous= 0/03 Increase, Interval= 0/05 Increase, Control= 0/02 Decrease). According to the paradox observed in obese and diabetes subjects can be said that apply the aerobic training in elderly subjects with such conditions requires specific design and likely to be that the implementation of traditional aerobic trainings will not have a significant effect on the WEGF serum and NO saliva levels. Conclusion: In the present study, we found that doing aerobics training in both continuous and interval courses had no significant effects on the level of angiogenesis and nitric oxide in the old men under study. However, we can maintain that taking aerobic trainings by subjects who suffer from diabetes, hypertension and obesity, based on results from previous studies has no positive effects. Patients suffering from diabetes, hypertension and obesity would see no significant change in their angiogenesis rate after doing continuous or interval aerobic trainings. [ABSTRACT FROM AUTHOR]