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2. Comprehensive whole-genome sequence analyses provide insights into the genomic architecture of cerebral palsy

Author

Fehlings, Darcy L., Zarrei, Mehdi, Engchuan, Worrawat, Sondheimer, Neal, Thiruvahindrapuram, Bhooma, MacDonald, Jeffrey R., Higginbotham, Edward J., Thapa, Ritesh, Behlim, Tarannum, Aimola, Sabrina, Switzer, Lauren, Ng, Pamela, Wei, John, Danthi, Prakroothi S., Pellecchia, Giovanna, Lamoureux, Sylvia, Ho, Karen, Pereira, Sergio L., de Rijke, Jill, Sung, Wilson W. L., Mowjoodi, Alireza, Howe, Jennifer L., Nalpathamkalam, Thomas, Manshaei, Roozbeh, Ghaffari, Siavash, Whitney, Joseph, Patel, Rohan V., Hamdan, Omar, Shaath, Rulan, Trost, Brett, Knights, Shannon, Samdup, Dawa, McCormick, Anna, Hunt, Carolyn, Kirton, Adam, Kawamura, Anne, Mesterman, Ronit, Gorter, Jan Willem, Dlamini, Nomazulu, Merico, Daniele, Hilali, Murto, Hirschfeld, Kyle, Grover, Kritika, Bautista, Nelson X., Han, Kara, Marshall, Christian R., Yuen, Ryan K. C., Subbarao, Padmaja, Azad, Meghan B., Turvey, Stuart E., Mandhane, Piush, Moraes, Theo J., Simons, Elinor, Maxwell, George, Shevell, Michael, Costain, Gregory, Michaud, Jacques L., Hamdan, Fadi F., Gauthier, Julie, Uguen, Kevin, Stavropoulos, Dimitri J., Wintle, Richard F., Oskoui, Maryam, and Scherer, Stephen W.

Published
2024
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3. Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children

Author

Ambalavanan, Amirthagowri, Chang, Le, Choi, Jihoon, Zhang, Yang, Stickley, Sara A., Fang, Zhi Y., Miliku, Kozeta, Robertson, Bianca, Yonemitsu, Chloe, Turvey, Stuart E., Mandhane, Piushkumar J., Simons, Elinor, Moraes, Theo J., Anand, Sonia S., Paré, Guillaume, Williams, Janet E., Murdoch, Brenda M., Otoo, Gloria E., Mbugua, Samwel, Kamau-Mbuthia, Elizabeth W., Kamundia, Egidioh W., Gindola, Debela K., Rodriguez, Juan M., Pareja, Rossina G., Sellen, Daniel W., Moore, Sophie E., Prentice, Andrew M., Foster, James A., Kvist, Linda J., Neibergs, Holly L., McGuire, Mark A., McGuire, Michelle K., Meehan, Courtney L., Sears, Malcolm R., Subbarao, Padmaja, Azad, Meghan B., Bode, Lars, and Duan, Qingling

Published
2024
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9. Divergent maturational patterns of the infant bacterial and fungal gut microbiome in the first year of life are associated with inter-kingdom community dynamics and infant nutrition

Author

Mercer, Emily M., Ramay, Hena R., Moossavi, Shirin, Laforest-Lapointe, Isabelle, Reyna, Myrtha E., Becker, Allan B., Simons, Elinor, Mandhane, Piush J., Turvey, Stuart E., Moraes, Theo J., Sears, Malcolm R., Subbarao, Padmaja, Azad, Meghan B., and Arrieta, Marie-Claire

Published
2024
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11. Evidence for human milk as a biological system and recommendations for study design—a report from “Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN)” Working Group 4

Author

Donovan, Sharon M, Aghaeepour, Nima, Andres, Aline, Azad, Meghan B, Becker, Martin, Carlson, Susan E, Järvinen, Kirsi M, Lin, Weili, Lönnerdal, Bo, Slupsky, Carolyn M, Steiber, Alison L, and Raiten, Daniel J

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Clinical Sciences, Nutrition, Clinical Research, Pediatric, Dental/Oral and Craniofacial Disease, Generic health relevance, Female, Infant, Humans, Milk, Human, Lactation, Infant Nutritional Physiological Phenomena, Breast Feeding, Infant Formula, human milk, infant development, immune, microbiome, systems biology, Engineering, Medical and Health Sciences, Nutrition & Dietetics, Clinical sciences, Nutrition and dietetics
Abstract

Human milk contains all of the essential nutrients required by the infant within a complex matrix that enhances the bioavailability of many of those nutrients. In addition, human milk is a source of bioactive components, living cells and microbes that facilitate the transition to life outside the womb. Our ability to fully appreciate the importance of this matrix relies on the recognition of short- and long-term health benefits and, as highlighted in previous sections of this supplement, its ecology (i.e., interactions among the lactating parent and breastfed infant as well as within the context of the human milk matrix itself). Designing and interpreting studies to address this complexity depends on the availability of new tools and technologies that account for such complexity. Past efforts have often compared human milk to infant formula, which has provided some insight into the bioactivity of human milk, as a whole, or of individual milk components supplemented with formula. However, this experimental approach cannot capture the contributions of the individual components to the human milk ecology, the interaction between these components within the human milk matrix, or the significance of the matrix itself to enhance human milk bioactivity on outcomes of interest. This paper presents approaches to explore human milk as a biological system and the functional implications of that system and its components. Specifically, we discuss study design and data collection considerations and how emerging analytical technologies, bioinformatics, and systems biology approaches could be applied to advance our understanding of this critical aspect of human biology.

Published
2023

14. Early sex-dependent differences in metabolic profiles of overweight and adiposity in young children: a cross-sectional analysis

Author

Azab, Sandi M, Shanmuganathan, Meera, de Souza, Russell J, Kroezen, Zachary, Desai, Dipika, Williams, Natalie C, Morrison, Katherine M, Atkinson, Stephanie A, Teo, Koon K, Azad, Meghan B, Simons, Elinor, Moraes, Theo J, Mandhane, Piush J, Turvey, Stuart E, Subbarao, Padmaja, Britz-McKibbin, Philip, and Anand, Sonia S

Published
2023
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15. Changes in preterm birth and stillbirth during COVID-19 lockdowns in 26 countries

Author

Calvert, Clara, Brockway, Meredith (Merilee), Zoega, Helga, Miller, Jessica E., Been, Jasper V., Amegah, Adeladza Kofi, Racine-Poon, Amy, Oskoui, Solmaz Eradat, Abok, Ishaya I., Aghaeepour, Nima, Akwaowo, Christie D., Alshaikh, Belal N., Ayede, Adejumoke I., Bacchini, Fabiana, Barekatain, Behzad, Barnes, Rodrigo, Bebak, Karolina, Berard, Anick, Bhutta, Zulfiqar A., Brook, Jeffrey R., Bryan, Lenroy R., Cajachagua-Torres, Kim N., Campbell-Yeo, Marsha, Chu, Dinh-Toi, Connor, Kristin L., Cornette, Luc, Cortés, Sandra, Daly, Mandy, Debauche, Christian, Dedeke, Iyabode Olabisi F., Einarsdóttir, Kristjana, Engjom, Hilde, Estrada-Gutierrez, Guadalupe, Fantasia, Ilaria, Fiorentino, Nicole M., Franklin, Meredith, Fraser, Abigail, Gachuno, Onesmus W., Gallo, Linda A., Gissler, Mika, Håberg, Siri E., Habibelahi, Abbas, Häggström, Jonas, Hookham, Lauren, Hui, Lisa, Huicho, Luis, Hunter, Karen J., Huq, Sayeeda, KC, Ashish, Kadambari, Seilesh, Kelishadi, Roya, Khalili, Narjes, Kippen, Joanna, Le Doare, Kirsty, Llorca, Javier, Magee, Laura A., Magnus, Maria C., Man, Kenneth K. C., Mburugu, Patrick M., Mediratta, Rishi P., Morris, Andrew D., Muhajarine, Nazeem, Mulholland, Rachel H., Bonnard, Livia Nagy, Nakibuuka, Victoria, Nassar, Natasha, Nyadanu, Sylvester D., Oakley, Laura, Oladokun, Adesina, Olayemi, Oladapo O., Olutekunbi, Olanike A., Oluwafemi, Rosena O., Ogunkunle, Taofik O., Orton, Chris, Örtqvist, Anne K., Ouma, Joseph, Oyapero, Oyejoke, Palmer, Kirsten R., Pedersen, Lars H., Pereira, Gavin, Pereyra, Isabel, Philip, Roy K., Pruski, Dominik, Przybylski, Marcin, Quezada-Pinedo, Hugo G., Regan, Annette K., Rhoda, Natasha R., Rihs, Tonia A., Riley, Taylor, Rocha, Thiago Augusto Hernandes, Rolnik, Daniel L., Saner, Christoph, Schneuer, Francisco J., Souter, Vivienne L., Stephansson, Olof, Sun, Shengzhi, Swift, Emma M., Szabó, Miklós, Temmerman, Marleen, Tooke, Lloyd, Urquia, Marcelo L., von Dadelszen, Peter, Wellenius, Gregory A., Whitehead, Clare, Wong, Ian C. K., Wood, Rachael, Wróblewska-Seniuk, Katarzyna, Yeboah-Antwi, Kojo, Yilgwan, Christopher S., Zawiejska, Agnieszka, Sheikh, Aziz, Rodriguez, Natalie, Burgner, David, Stock, Sarah J., and Azad, Meghan B.

Published
2023
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16. Genome-wide enhancer-associated tandem repeats are expanded in cardiomyopathy

Author

Mitina, Aleksandra, Khan, Mahreen, Lesurf, Robert, Yin, Yue, Engchuan, Worrawat, Hamdan, Omar, Pellecchia, Giovanna, Trost, Brett, Backstrom, Ian, Guo, Keyi, Pallotto, Linda M., Lam Doong, Phoenix Hoi, Wang, Zhuozhi, Nalpathamkalam, Thomas, Thiruvahindrapuram, Bhooma, Papaz, Tanya, Pearson, Christopher E., Ragoussis, Jiannis, Subbarao, Padmaja, Azad, Meghan B., Turvey, Stuart E., Mandhane, Piushkumar, Moraes, Theo J., Simons, Elinor, Scherer, Stephen W., Lougheed, Jane, Mondal, Tapas, Smythe, John, Altamirano-Diaz, Luis, Oechslin, Erwin, Mital, Seema, and Yuen, Ryan K.C.

Published
2024
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17. Human Milk Macronutrients and Child Growth and Body Composition in the First Two Years: A Systematic Review

Author

Brockway, Meredith (Merilee), Daniel, Allison I., Reyes, Sarah M., Granger, Matthew, McDermid, Joann M., Chan, Deborah, Refvik, Rebecca, Sidhu, Karanbir K., Musse, Suad, Patel, Pooja P., Monnin, Caroline, Lotoski, Larisa, Geddes, Donna, Jehan, Fyezah, Kolsteren, Patrick, Allen, Lindsay H., Hampel, Daniela, Eriksen, Kamilla G., Rodriguez, Natalie, and Azad, Meghan B.

Published
2024
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18. Human Milk Bioactive Components and Child Growth and Body Composition in the First 2 Years: A Systematic Review

Author

Brockway, Meredith (Merilee), Daniel, Allison I., Reyes, Sarah M., Gauglitz, Julia M., Granger, Matthew, McDermid, Joann M., Chan, Deborah, Refvik, Rebecca, Sidhu, Karanbir K., Musse, Suad, Patel, Pooja P., Monnin, Caroline, Lotoski, Larisa, Geddes, Donna T., Jehan, Fyezah, Kolsteren, Patrick, Bode, Lars, Eriksen, Kamilla G., Allen, Lindsay H., Hampel, Daniela, Rodriguez, Natalie, and Azad, Meghan B.

Published
2024
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20. Breastfeeding and the origins of health: Interdisciplinary perspectives and priorities

Author

Azad, Meghan B, Nickel, Nathan C, Bode, Lars, Brockway, Meredith, Brown, Amy, Chambers, Christina, Goldhammer, Camie, Hinde, Katie, McGuire, Michelle, Munblit, Daniel, Patel, Aloka L, Pérez‐Escamilla, Rafael, Rasmussen, Kathleen M, Shenker, Natalie, Young, Bridget E, and Zuccolo, Luisa

Subjects
Public Health, Health Sciences, Nutrition, Pediatric, Good Health and Well Being, Breast Feeding, Female, Humans, Infant, Milk, Human, breastfeeding, breastmilk, conflict of interest, human milk, infant feeding, lactation, research methodology, Nutrition and Dietetics, Nutrition & Dietetics, Nutrition and dietetics, Midwifery
Abstract

Breastfeeding and human milk (HM) are critically important to maternal, infant and population health. This paper summarizes the proceedings of a workshop that convened a multidisciplinary panel of researchers to identify key priorities and anticipated breakthroughs in breastfeeding and HM research, discuss perceived barriers and challenges to achieving these breakthroughs and propose a constructive action plan to maximize the impact of future research in this field. Priority research areas identified were as follows: (1) addressing low breastfeeding rates and inequities using mixed methods, community partnerships and implementation science approaches; (2) improving awareness of evidence-based benefits, challenges and complexities of breastfeeding and HM among health practitioners and the public; (3) identifying differential impacts of alternative modes of HM feeding including expressed/pumped milk, donor milk and shared milk; and (4) developing a mechanistic understanding of the health effects of breastfeeding and the contributors to HM composition and variability. Key barriers and challenges included (1) overcoming methodological limitations of epidemiological breastfeeding research and mechanistic HM research; (2) counteracting 'breastfeeding denialism' arising from negative personal breastfeeding experiences; (3) distinguishing and aligning research and advocacy efforts; and (4) managing real and perceived conflicts of interest. To advance research on breastfeeding and HM and maximize the reach and impact of this research, larger investments are needed, interdisciplinary collaboration is essential, and the scientific community must engage families and other stakeholders in research planning and knowledge translation.

Published
2021

22. Longitudinal body mass index trajectories at preschool age: children with rapid growth have differential composition of the gut microbiota in the first year of life

Author

Reyna, Myrtha E., Petersen, Charisse, Dai, Darlene L. Y., Dai, Ruixue, Becker, Allan B., Azad, Meghan B., Miliku, Kozeta, Lefebvre, Diana L., Moraes, Theo J., Mandhane, Piushkumar J., Boutin, Rozlyn C. T., Finlay, B. Brett, Simons, Elinor, Kozyrskyj, Anita L., Lou, Wendy, Turvey, Stuart E., and Subbarao, Padmaja

Published
2022
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23. The potential importance of the built-environment microbiome and its impact on human health

Author

Bosch, Thomas C. G., primary, Wigley, Mark, additional, Colomina, Beatriz, additional, Bohannan, Brendan, additional, Meggers, Forrest, additional, Amato, Katherine R., additional, Azad, Meghan B., additional, Blaser, Martin J., additional, Brown, Kate, additional, Dominguez-Bello, Maria Gloria, additional, Ehrlich, Stanislav Dusko, additional, Elinav, Eran, additional, Finlay, B. Brett, additional, Geddie, Kate, additional, Geva-Zatorsky, Naama, additional, Giles-Vernick, Tamara, additional, Gros, Philippe, additional, Guillemin, Karen, additional, Haraoui, Louis-Patrick, additional, Johnson, Elizabeth, additional, Keck, Frédéric, additional, Lorimer, Jamie, additional, McFall-Ngai, Margaret J., additional, Nichter, Mark, additional, Pettersson, Sven, additional, Poinar, Hendrik, additional, Rees, Tobias, additional, Tropini, Carolina, additional, Undurraga, Eduardo A., additional, Zhao, Liping, additional, and Melby, Melissa K., additional

Published
2024
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24. Antibiotics within first year are linked to infant gut microbiome disruption and elevated atopic dermatitis risk

Author

Hoskinson, Courtney, primary, Medeleanu, Maria V., additional, Reyna, Myrtha E., additional, Dai, Darlene LY., additional, Chowdhury, Biswajit, additional, Moraes, Theo J., additional, Mandhane, Piushkumar J., additional, Simons, Elinor, additional, Kozyrskyj, Anita L., additional, Azad, Meghan B., additional, Petersen, Charisse, additional, Turvey, Stuart E., additional, and Subbarao, Padmaja, additional

Published
2024
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25. The human gut microbiome and health inequities

Author

Amato, Katherine R., Arrieta, Marie-Claire, Azad, Meghan B., Bailey, Michael T., Broussard, Josiane L., Bruggeling, Carlijn E., Claud, Erika C., Costello, Elizabeth K., Davenport, Emily R., Dutilh, Bas E., Ewald, Holly A. Swain, Ewald, Paul, Hanlon, Erin C., Julion, Wrenetha, Keshavarzian, Ali, Maurice, Corinne F., Miller, Gregory E., Preidis, Geoffrey A., Segurel, Laure, Singer, Burton, Subramanian, Sathish, Zhao, Liping, and Kuzawa, Christopher W.

Published
2021

26. Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations.

Author

Ho, Nhan T, Li, Fan, Lee-Sarwar, Kathleen A, Tun, Hein M, Brown, Bryan P, Pannaraj, Pia S, Bender, Jeffrey M, Azad, Meghan B, Thompson, Amanda L, Weiss, Scott T, Azcarate-Peril, M Andrea, Litonjua, Augusto A, Kozyrskyj, Anita L, Jaspan, Heather B, Aldrovandi, Grace M, and Kuhn, Louise

Subjects
Humans, Diarrhea, Biodiversity, Breast Feeding, Child, Preschool, Infant, Female, Dysbiosis, Gastrointestinal Microbiome, Nutrition, Infant Mortality, Pediatric, Emerging Infectious Diseases, Child, Preschool
Abstract

Previous studies on the differences in gut microbiota between exclusively breastfed (EBF) and non-EBF infants have provided highly variable results. Here we perform a meta-analysis of seven microbiome studies (1825 stool samples from 684 infants) to compare the gut microbiota of non-EBF and EBF infants across populations. In the first 6 months of life, gut bacterial diversity, microbiota age, relative abundances of Bacteroidetes and Firmicutes, and predicted microbial pathways related to carbohydrate metabolism are consistently higher in non-EBF than in EBF infants, whereas relative abundances of pathways related to lipid metabolism, vitamin metabolism, and detoxification are lower. Variation in predicted microbial pathways associated with non-EBF infants is larger among infants born by Caesarian section than among those vaginally delivered. Longer duration of exclusive breastfeeding is associated with reduced diarrhea-related gut microbiota dysbiosis. Furthermore, differences in gut microbiota between EBF and non-EBF infants persist after 6 months of age. Our findings elucidate some mechanisms of short and long-term benefits of exclusive breastfeeding across different populations.

Published
2018

28. Food Proteins in Human Breast Milk and Probability of IgE-Mediated Allergic Reaction in Children During Breastfeeding: A Systematic Review

Author

Gamirova, Aysylu, Berbenyuk, Anna, Levina, Daria, Peshko, Dmitrii, Simpson, Melanie R., Azad, Meghan B., Järvinen, Kirsi M., Brough, Helen A., Genuneit, Jon, Greenhawt, Matthew, Verhasselt, Valerie, Peroni, Diego G., Perkin, Michael R., Warner, John O., Palmer, Debra J., Boyle, Robert J., and Munblit, Daniel

Published
2022
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31. Human Milk Micronutrients and Child Growth and Body Composition in the First 2 years:A Systematic Review

Author

Reyes, Sarah M., Brockway, Meredith (Merilee), McDermid, Joann M., Chan, Deborah, Granger, Matthew, Refvik, Rebecca, Sidhu, Karanbir K., Musse, Suad, Monnin, Caroline, Lotoski, Larisa, Geddes, Donna T., Jehan, Fyezah, Kolsteren, Patrick, Allen, Lindsay H., Hampel, Daniela, Eriksen, Kamilla G., Rodriguez, Natalie, Azad, Meghan B., Reyes, Sarah M., Brockway, Meredith (Merilee), McDermid, Joann M., Chan, Deborah, Granger, Matthew, Refvik, Rebecca, Sidhu, Karanbir K., Musse, Suad, Monnin, Caroline, Lotoski, Larisa, Geddes, Donna T., Jehan, Fyezah, Kolsteren, Patrick, Allen, Lindsay H., Hampel, Daniela, Eriksen, Kamilla G., Rodriguez, Natalie, and Azad, Meghan B.

Abstract

Human milk (HM) provides a plethora of nutritional and non-nutritional compounds that support infant development. For many compounds, concentrations vary substantially among mothers and across lactation, and their impact on infant growth is poorly understood. We systematically searched MEDLINE, Embase, the Cochrane Library, Scopus, and Web of Science to synthesize evidence published between 1980 and 2022 on HM components and anthropometry through 2 y of age among term-born infants. Outcomes included weight-for-length, length-for-age, weight-for-age, body mass index (in kg/m2)–for–age, and growth velocity. From 9992 abstracts screened, 144 articles were included and categorized based on their reporting of HM micronutrients, macronutrients, or bioactive components. Micronutrients (vitamins and minerals) are reported here, based on 28 articles involving 2526 mother-infant dyads. Studies varied markedly in their designs, sampling times, geographic and socioeconomic settings, reporting practices, and the HM analytes and infant anthropometrics measured. Meta-analysis was not possible because data were sparse for most micronutrients. The most-studied minerals were zinc (15 articles, 1423 dyads) and calcium (7 articles, 714 dyads). HM iodine, manganese, calcium, and zinc concentrations were positively associated with several outcomes (each in ≥2 studies), whereas magnesium (in a single study) was negatively associated with linear growth during early lactation. However, few studies measured HM intake, adjusted for confounders, provided adequate information about complementary and formula feeding, or adequately described HM collection protocols. Only 4 studies (17%) had high overall quality scores. The biological functions of individual HM micronutrients are likely influenced by other HM components; yet, only 1 study analyzed data from multiple micronutrients simultaneously, and few addressed other HM components. Thus, available evidence on this topic is largely

Published
2024

32. Human Milk Macronutrients and Child Growth and Body Composition in the First Two Years:A Systematic Review

Author

Brockway, Meredith (Merilee), Daniel, Allison I., Reyes, Sarah M., Granger, Matthew, McDermid, Joann M., Chan, Deborah, Refvik, Rebecca, Sidhu, Karanbir K., Musse, Suad, Patel, Pooja P., Monnin, Caroline, Lotoski, Larisa, Geddes, Donna, Jehan, Fyezah, Kolsteren, Patrick, Allen, Lindsay H., Hampel, Daniela, Eriksen, Kamilla G., Rodriguez, Natalie, Azad, Meghan B., Brockway, Meredith (Merilee), Daniel, Allison I., Reyes, Sarah M., Granger, Matthew, McDermid, Joann M., Chan, Deborah, Refvik, Rebecca, Sidhu, Karanbir K., Musse, Suad, Patel, Pooja P., Monnin, Caroline, Lotoski, Larisa, Geddes, Donna, Jehan, Fyezah, Kolsteren, Patrick, Allen, Lindsay H., Hampel, Daniela, Eriksen, Kamilla G., Rodriguez, Natalie, and Azad, Meghan B.

Abstract

Among exclusively breastfed infants, human milk (HM) provides complete nutrition in the first mo of life and remains an important energy source as long as breastfeeding continues. Consisting of digestible carbohydrates, proteins, and amino acids, as well as fats and fatty acids, macronutrients in human milk have been well studied; however, many aspects related to their relationship to growth in early life are still not well understood. We systematically searched Medline, EMBASE, the Cochrane Library, Scopus, and Web of Science to synthesize evidence published between 1980 and 2022 on HM components and anthropometry through 2 y of age among term-born healthy infants. From 9992 abstracts screened, 57 articles reporting observations from 5979 dyads were included and categorized based on their reporting of HM macronutrients and infant growth. There was substantial heterogeneity in anthropometric outcome measurement, milk collection timelines, and HM sampling strategies; thus, meta-analysis was not possible. In general, digestible carbohydrates were positively associated with infant weight outcomes. Protein was positively associated with infant length, but no associations were reported for infant weight. Finally, HM fat was not consistently associated with any infant growth metrics, though various associations were reported in single studies. Fatty acid intakes were generally positively associated with head circumference, except for docosahexaenoic acid. Our synthesis of the literature was limited by differences in milk collection strategies, heterogeneity in anthropometric outcomes and analytical methodologies, and by insufficient reporting of results. Moving forward, HM researchers should accurately record and account for breastfeeding exclusivity, use consistent sampling protocols that account for the temporal variation in HM macronutrients, and use reliable, sensitive, and accurate techniques for HM macronutrient analysis.

Published
2024

33. Human Milk Bioactive Components and Child Growth and Body Composition in the First 2 Years:A Systematic Review

Author

Brockway, Meredith (Merilee), Daniel, Allison I., Reyes, Sarah M., Gauglitz, Julia M., Granger, Matthew, McDermid, Joann M., Chan, Deborah, Refvik, Rebecca, Sidhu, Karanbir K., Musse, Suad, Patel, Pooja P., Monnin, Caroline, Lotoski, Larisa, Geddes, Donna T., Jehan, Fyezah, Kolsteren, Patrick, Bode, Lars, Eriksen, Kamilla G., Allen, Lindsay H., Hampel, Daniela, Rodriguez, Natalie, Azad, Meghan B., Brockway, Meredith (Merilee), Daniel, Allison I., Reyes, Sarah M., Gauglitz, Julia M., Granger, Matthew, McDermid, Joann M., Chan, Deborah, Refvik, Rebecca, Sidhu, Karanbir K., Musse, Suad, Patel, Pooja P., Monnin, Caroline, Lotoski, Larisa, Geddes, Donna T., Jehan, Fyezah, Kolsteren, Patrick, Bode, Lars, Eriksen, Kamilla G., Allen, Lindsay H., Hampel, Daniela, Rodriguez, Natalie, and Azad, Meghan B.

Abstract

Human milk (HM) contains macronutrients, micronutrients, and a multitude of other bioactive factors, which can have a long-term impact on infant growth and development. We systematically searched MEDLINE, EMBASE, Cochrane Library, Scopus, and Web of Science to synthesize evidence published between 1980 and 2022 on HM components and anthropometry through 2 y of age among term-born infants. From 9992 abstracts screened, 141 articles were included and categorized based on their reporting of HM micronutrients, macronutrients, or bioactive components. Bioactives including hormones, HM oligosaccharides (HMOs), and immunomodulatory components are reported here, based on 75 articles from 69 unique studies reporting observations from 9980 dyads. Research designs, milk collection strategies, sampling times, geographic and socioeconomic settings, reporting practices, and outcomes varied considerably. Meta-analyses were not possible because data collection times and reporting were inconsistent among the studies included. Few measured infant HM intake, adjusted for confounders, precisely captured breastfeeding exclusivity, or adequately described HM collection protocols. Only 5 studies (6%) had high overall quality scores. Hormones were the most extensively examined bioactive with 46 articles (n = 6773 dyads), compared with 13 (n = 2640 dyads) for HMOs and 12 (n = 1422 dyads) for immunomodulatory components. Two studies conducted untargeted metabolomics. Leptin and adiponectin demonstrated inverse associations with infant growth, although several studies found no associations. No consistent associations were found between individual HMOs and infant growth outcomes. Among immunomodulatory components in HM, IL-6 demonstrated inverse relationships with infant growth. Current research on HM bioactives is largely inconclusive and is insufficient to address the complex composition of HM. Future research should ideally capture HM intake, use biologically relevant anthropometrics, an

Published
2024

38. Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry

Author

Deng, Wei Q., primary, Cawte, Nathan, additional, Campbell, Natalie, additional, Azab, Sandi M., additional, de Souza, Russell J, additional, Lamri, Amel, additional, Morrison, Katherine M., additional, Atkinson, Stephanie A., additional, Subbarao, Padmaja, additional, Turvey, Stuart E., additional, Moraes, Theo J., additional, Teo, Koon K., additional, Mandhane, Piush, additional, Azad, Meghan B., additional, Simons, Elinor, additional, Pare, Guillaume, additional, and Anand, Sonia S., additional

Published
2024
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39. Piloting the Use of Federated Analysis to Enhance Privacy and Enable Trustworthy Access to Covid-19 Research Data

Author

Eradat Oskoui, Solmaz, primary, Barnes, Rodrigo, additional, Forde, Eoghan, additional, Retford, Matthew, additional, Postlethwaite, Neil, additional, Hunter, Karen J., additional, Wozencraft, Anne, additional, Thompson, Simon, additional, Orton, Chris, additional, Ford, D.V., additional, Heys, Sharon, additional, Kennedy, Julie, additional, McNerney, Cynthia, additional, Peng, Jeffrey, additional, Ghanbariadolat, Hamed, additional, Rees, Sarah, additional, Mulholland, Rachel H., additional, Sheikh, Aziz, additional, Burgner, David, additional, Brockway, Meredith Lee, additional, Azad, Meghan B., additional, Rodriguez, Natalie, additional, Zoega, Helga, additional, Stock, Sarah J., additional, Calvert, Clara, additional, Miller, Jessica, additional, Fiorentino, Nicole, additional, Racine, Amy, additional, and Haggstrom, Jonas, additional

Published
2024
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41. From Birth to Overweight and Atopic Disease: Multiple and Common Pathways of the Infant Gut Microbiome

Author

Vu, Khanh, Lou, Wendy, Tun, Hein M., Konya, Theodore B., Morales-Lizcano, Nadia, Chari, Radha S., Field, Catherine J., Guttman, David S., Mandal, Rupasri, Wishart, David S., Azad, Meghan B., Becker, Allan B., Mandhane, Piush J., Moraes, Theo J., Lefebvre, Diana L., Sears, Malcolm R., Turvey, Stuart E., Subbarao, Padmaja, Scott, James A., and Kozyrskyj, Anita L.

Published
2021
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43. Decreasing antibiotic use, the gut microbiota, and asthma incidence in children: evidence from population-based and prospective cohort studies

Author

Patrick, David M, Sbihi, Hind, Dai, Darlene L Y, Al Mamun, Abdullah, Rasali, Drona, Rose, Caren, Marra, Fawziah, Boutin, Rozlyn C T, Petersen, Charisse, Stiemsma, Leah T, Winsor, Geoffrey L, Brinkman, Fiona S L, Kozyrskyj, Anita L, Azad, Meghan B, Becker, Allan B, Mandhane, Piush J, Moraes, Theo J, Sears, Malcolm R, Subbarao, Padmaja, Finlay, B Brett, and Turvey, Stuart E

Published
2020
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49. Human Milk Bioactive Components and Child Growth and Body Composition in the First 2 Years: A Systematic Review

Author

Brockway, Meredith (Merilee), primary, Daniel, Allison I., additional, Reyes, Sarah M., additional, Gauglitz, Julia M., additional, Granger, Matthew, additional, McDermid, Joann M., additional, Chan, Deborah, additional, Refvik, Rebecca, additional, Sidhu, Karanbir K., additional, Musse, Suad, additional, Patel, Pooja P., additional, Monnin, Caroline, additional, Lotoski, Larisa, additional, Geddes, Donna T., additional, Jehan, Fyezah, additional, Kolsteren, Patrick, additional, Bode, Lars, additional, Eriksen, Kamilla G., additional, Allen, Lindsay H., additional, Hampel, Daniela, additional, Rodriguez, Natalie, additional, and Azad, Meghan B., additional

Published
2023
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