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1. Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

Author

Garcia-Alonso, Luz, Handfield, Louis-François, Roberts, Kenny, Nikolakopoulou, Konstantina, Fernando, Ridma C., Gardner, Lucy, Woodhams, Benjamin, Arutyunyan, Anna, Polanski, Krzysztof, Hoo, Regina, Sancho-Serra, Carmen, Li, Tong, Kwakwa, Kwasi, Tuck, Elizabeth, Lorenzi, Valentina, Massalha, Hassan, Prete, Martin, Kleshchevnikov, Vitalii, Tarkowska, Aleksandra, Porter, Tarryn, Mazzeo, Cecilia Icoresi, van Dongen, Stijn, Dabrowska, Monika, Vaskivskyi, Vasyl, Mahbubani, Krishnaa T., Park, Jong-eun, Jimenez-Linan, Mercedes, Campos, Lia, Kiselev, Vladimir Yu., Lindskog, Cecilia, Ayuk, Paul, Prigmore, Elena, Stratton, Michael R., Saeb-Parsy, Kourosh, Moffett, Ashley, Moore, Luiza, Bayraktar, Omer A., Teichmann, Sarah A., Turco, Margherita Y., and Vento-Tormo, Roser

Published
2021
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3. Author Correction: Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

Author

Garcia-Alonso, Luz, Handfield, Louis-François, Roberts, Kenny, Nikolakopoulou, Konstantina, Fernando, Ridma C., Gardner, Lucy, Woodhams, Benjamin, Arutyunyan, Anna, Polanski, Krzysztof, Hoo, Regina, Sancho-Serra, Carmen, Li, Tong, Kwakwa, Kwasi, Tuck, Elizabeth, Lorenzi, Valentina, Massalha, Hassan, Prete, Martin, Kleshchevnikov, Vitalii, Tarkowska, Aleksandra, Porter, Tarryn, Mazzeo, Cecilia Icoresi, van Dongen, Stijn, Dabrowska, Monika, Vaskivskyi, Vasyl, Mahbubani, Krishnaa T., Park, Jong-eun, Jimenez-Linan, Mercedes, Campos, Lia, Kiselev, Vladimir Yu., Lindskog, Cecilia, Ayuk, Paul, Prigmore, Elena, Stratton, Michael R., Saeb-Parsy, Kourosh, Moffett, Ashley, Moore, Luiza, Bayraktar, Omer A., Teichmann, Sarah A., Turco, Margherita Y., and Vento-Tormo, Roser

Published
2023
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5. Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial

Author

Shakur, Haleema, Roberts, Ian, Fawole, Bukola, Chaudhri, Rizwana, El-Sheikh, Mohamed, Akintan, Adesina, Qureshi, Zahida, Kidanto, Hussein, Vwalika, Bellington, Abdulkadir, Abdulfetah, Etuk, Saturday, Noor, Shehla, Asonganyi, Etienne, Alfirevic, Zarko, Beaumont, Danielle, Ronsmans, Carine, Arulkumaran, Sabaratnam, Grant, Adrian, Afsana, Kaosar, Gülmezoglu, Metin, Hunt, Beverley, Olayemi, Oladapo, Chalmers, Iain, Lumbiganon, Pisake, Piaggio, Gilda, Brady, Tony, Elbourne, Diana, Balogun, Eni, Pepple, Tracey, Prowse, Danielle, Quashi, Nigel, Barneston, Lin, Barrow, Collette, Cook, Lisa, Frimley, Lauren, Gilbert, Daniel, Gilliam, Catherine, Jackson, Rob, Kawahara, Taemi, Miah, Hakim, Kostrov, Sergey, Ramos, Maria, Edwards, Phil, Godec, Tom, Huque, Sumaya, Okunade, Olujide, Adetayo, Olusade, Kayani, Aasia, Javaid, Kiran, Biryabarema, Chrstine, Tchounzou, Robert, Regmi, Mohan, Dallaku, Kastriot, Sahani, Mateus, Akhter, Sayeba, Meda, Nicolas, Dah, Anthony Kwame, Odekunle, Olufemi, Monehin, Oluwabusola, Ojo, Austin, Akinbinu, Grace, Offiah, Ifeoma, Akpan, Ubong, Udofia, Uduak, Okon, Useneno, Omoronyia, Ezukwa, James, Okpe, Bello, Nike, Adeyemi, Blessed, Aimakhu, Chris, Akinsanya, Olufemi, Adeleye, Bamidele, Adeyemi, Oluwaseun, Oluwatosin, Kayode, Aboyeji, Abiodun, Adeniran, Abiodun, Adewale, Adebayo, Olaomo, Noah, Omo-Aghoja, Lawrence, Okpako, Emmanuel, Oyeye, Lucky, Alu, Francis, Ogudu, John, Ladan, Ezekiel, Habib, Ibrahim, Okusanya, Babasola, Onafowokan, Olatunde, Isah, David, Aye, Abalaka, Okogbo, Felix, Aigere, Egbaname, Ogbiti, Mark, Onile, Temitope, Salau, Olaide, Amode, Yinka, Shoretire, Kamil, Owodunni, Adebola, Ologunde, Kehinde, Ayinde, Akintunde, Alao, Moses, Awonuga, Olalekan, Awolaja, Babatunde, Adegbola, Omololu, Habeebu-Adeyemi, Fatimah, Okunowo, Adeyemi, Idris, Hadiza, Okike, Ola, Madueke, Nneka, Mutihir, Josiah, Joseph, Nankat, Adebudo, Babatunde, Fasanu, Adeniyi, Akintunde, Olugbenga, Abidoye, Olufemi, Opreh, Owigho, Udonwa, Sophia, Dibia, Gladys, Bazuaye, Simeon, Ifemeje, Arafat, Umoiyoho, Aniefiok, Inyang-Etoh, Emmanuel, Yusuf, Sununu, Olayinka, Kayode, Adeyemi, Babalola, Ajenifuja, Olusegun, Ibrahim, Umar, Adamu, Yusuf Baffah, Akinola, Oluwarotimi, Adekola-Oni, Grace, Kua, Paul, Iheagwam, Roseline, Idrisa, Audu, Geidam, Ado, Jogo, Andrea, Agulebe, Joseph, Ikechebelu, Joseph, Udegbunam, Onyebuchi, Awoleke, Jacob, Adelekan, Oluseyi, Sulayman, Hajaratu, Ameh, Nkeiruka, Onaolapo, Nurudeen, Adelodun, Affiss, Golit, William, Audu, Dachollom, Adeniji, Adetunji, Oyelade, Folasade, Dattijo, Lamaran, Henry, Palmer, Loto, Olabisi, Umeora, Odidika, Onwe, Abraham, Nzeribe, Emily, Okorochukwu, Bartthy, Adeniyi, Augustine, Gbejegbe, Emmanuel, Ikpen, Akpojaro, Nwosu, Ikemefuna, Sambo, Abdulrasaq, Ladipo, Olubunmi, Abubakar, Sola, Okike, Ola Nene, Nduka, Enyinnaya Chikwendu, Ezenkwele, Eziamaka Pauline, Onwusulu, Daniel, Irinyenikan, Theresa Azonima, Singh, Swati, Bariweni, Amaitari, Galadanci, Hadiza, Achara, Peter, Osayande, Osagie, Gana, Mohammed, Jabeen, Kiran, Mobeen, Ayesha, Mufti, Sadaf, Zafar, Maliha, Ahmad, Basharat, Munawar, Maimoona, Gul, Jeharat, Usman, Naseema, Shaheen, Fehmida, Tariq, Mariam, Sadiq, Nadia, Batool, Rabia, Ali, Habiba Sharaf, Jaffer, Manahil, Baloch, Asma, Mukhtiar, Noonari, Ashraf, Tasneem, Asmat, Raheela, Khudaidad, Salma, Taj, Ghazala, Qazi, Roshan, Dars, Saira, Sardar, Faryal, Ashfaq, Sanobar, Majeed, Saeeda, Jabeen, Sadaqat, Karim, Rukhsana, Burki, Farzana, Bukhari, Syeda Rabia, Gul, Fouzia, Jabeen, Musarrat, Sherin, Akhtar, Ain, Qurratul, Rao, Shahid, Shaheen, Uzma, Manzoor, Samina, Masood, Shabween, Rizvi, Shabana, Ali, Anita, Sajid, Abida, Iftikhar, Aisha, Batool, Shazia, Dar, Lubna, Sohail, Shahenzad, Rasul, Shazia, Humayun, Shamsa, Sultana, Rashida, Manzoor, Sofia, Mazhar, Syeda, Batool, Afshan, Nazir, Asia, Tasnim, Nasira, Masood, Hajira, Khero, Razia, Surhio, Neelam, Aleem, Samana, Israr, Naila, Javed, Saba, Bashir, Lubna, Iqbal, Samina, Aleem, Faiza, Sohail, Rubina, Iqbal, Saima, Dojki, Samina, Bano, Alia, Saba, Naseem, Hafeez, Maimoona, Akram, Nishat, Shaheen, Riffat, Hashmi, Haleema, Arshad, Sharmeen, Hussain, Rubina, Khan, Sadia, Shaheen, Nighat, Khalil, Safia, Sachdev, Pushpa, Arain, Gulfareen, Zarreen, Amtullah, Saeed, Sara, Hanif, Shamayela, Tariq, Nabia, Jamil, Mahwish, Chaudhry, Shama, Rajani, Hina, Wasim, Tayyiba, Aslam, Summera, Mustafa, Nilofar, Quddusi, Huma, Karim, Sajila, Sultana, Shazia, Harim, Misbah, Chohan, Mohd, Salman, Nabila, Waqar, Fareesa, Sadia, Shamsunnisa, Kahloon, Lubna, Manzoor, Shehla, Amin, Samar, Akram, Umbreen, Ikram, Ambreen, Kausar, Samina, Batool, Tahira, Naila, Brigadier, Kyani, Tahir, Biryabarema, Christine, Bulime, Ruth, Akello, Regina, Lwasa, Bernadette Nakawooya, Ayikoru, Joselyn, Namulwasira, Christine, Komagum, Patrick, Rebecca, Isabirye, Annet, Nayiga, Nuulu, Nakirigya, Nionzima, Elizabeth, Bwotya, Rose, Nankya, Margret, Babirye, Sarah, (RIP), Ngonzi, Joseph, Sanchez, Cesar, Innocent, Nkonwa, Anitah, Kusasira, Jackson, Ayiko, Ndagire, Elizabeth, Nanyongo, Christine, Drametu, Dominic, Meregurwa, Grace, Banya, Francis, Atim, Rita, Byaruhanga, Emmanuel, Felix, Lema, Iman, Hussein, Oyiengo, Vincent, Waigi, Peninah, Wangui, Rose, Nassir, Faiza, Soita, Musimbi, Msengeti, Rophina, Zubier, Zeinab, Mabeya, Hillary, Wanjala, Antony, Mwangi, Henry, Liyayi, Brian, Muthoka, Evelyn, Osoti, Alfred, Otara, Amos, Ongwae, Veronicah, Wanjohi, Victor, Musila, Bonface, Wekesa, Kubasu, Bosire, Alex Nyakundi, Ntem, Alice, Njoache, Angeline, Ashu, Alice, Simo, André, Keka, Dorothy, Bruno, Kenfack, Ndouoya, Amadou, Saadio, Martin, Tchana, Mesack, Gwan, Odel, Assomo, Pauline, Mutsu, Venantius, Eric, Nji, Foumane, Pascal, Nsem, Philemon, Fouedjio, Jeanne, Fouelifack, Ymele, Tebeu, Pierre Marie, Nko'ayissi, Georges, Mbong, Eta Ngole, Nabag, Wisal, Desougi, Riham, Mustafa, Hadia, Eltaib, Huida, Umbeli, Taha, Elfadl, Khalid, Ibrahim, Murwan, Mohammed, Abdalla, Ali, Awadia, Abdelrahiem, Somia, Musa, Mohammed, Awadalla, Khidir, Ahmed, Samirra, Bushra, Mahdi, Babiker, Omer, Abdullahi, Hala, Ahmed, Mohamed, Safa, Elhassan, Almardi, Huida, Rayis, Duria, Abdelgabar, Saeed Abdelrahman, Houghton, Gillian, Sharpe, Andrew, Thornton, Jim, Grace, Nick, Smith, Carys, Hinshaw, Kim, Edmundson, Dawn, Ayuk, Paul, Bates, Alison, Bugg, George, Wilkins, Joanne, Tower, Clare, Allibone, Alysha, Oteng-Ntim, Eugene, Kazumari, Ahmad, Danford, Anna, Ngarina, Matilda, Abeid, Muzdalifat, Mayumba, Khadija, Zacharia, Magreth, Mtove, George, Madame, Leonard, Massinde, Anthony, Mwambe, Berno, Onesmo, Rwakyendela, Ganyaka, Sebastian Kitengile, Gupta, Shyam, Bhatt, Rabindra, Agrawal, Ajay, Pradhan, Pramila, Dhakal, Nikita, Yadav, Punita, Karki, Gyanendra, Shrestha, Bhola Ram, Lubeya, Mwansa, Mumba, Jane, Silwimba, Willies, Hansingo, Isaiah, Bopili, Noojiri, Makukula, Ziche, Kawimbe, Alexander, Lubeya, Mwansa Ketty, Mtambo, Willard, Ng'ambi, Mathew, Cenameri, Saimir, Tasha, Ilir, Kruja, Aferdita, Brahimaj, Besnik, Tola, Armida, Kaza, Leon, Tshombe, Desire, Buligho, Elizabeth, Paluku-Hamuli, Roger, Kacha, Charles, Faida, Kato, Musau, Badibanga, Kalyana, Herman, Simisi, Phanny, Mulyumba, Serge, Jason, Nzanzu Kikuhe, Lubamba, Jean Robert, Missumba, Willis, Islam, Ferdousi, Begum, Nazneen, Chowdhury, Ferdousi, Begum, Rokeya, Basher, Farjana, Nargis, Nazlima, Kholdun, Abu, Jesmin, Shahela, Paul, Shrodha, Segni, Hailemariam, Ayana, Getachew, Haleke, William, Hussien, Hassen, Geremew, Fikre, Bambara, Moussa, Somé, Adolphe, Ly, Amadou, Pabakba, Roamba, Fletcher, Horace, Samuels, Leslie, Opare-Addo, Henry, Larsen-Reindorf, Roderick, Nyarko-Jectey, Kwadwo, Mola, Glen, Wai, Malts, El Rahman, Magdy, Basta, Wafaa, Khamis, Hussein, Escobar, Maria Fernanda, Vallecilla, Liliana, and Faye, Gabriel Essetchi

Published
2017
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8. Author Correction: Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

Author

Garcia-Alonso, Luz, primary, Handfield, Louis-François, additional, Roberts, Kenny, additional, Nikolakopoulou, Konstantina, additional, Fernando, Ridma C., additional, Gardner, Lucy, additional, Woodhams, Benjamin, additional, Arutyunyan, Anna, additional, Polanski, Krzysztof, additional, Hoo, Regina, additional, Sancho-Serra, Carmen, additional, Li, Tong, additional, Kwakwa, Kwasi, additional, Tuck, Elizabeth, additional, Lorenzi, Valentina, additional, Massalha, Hassan, additional, Prete, Martin, additional, Kleshchevnikov, Vitalii, additional, Tarkowska, Aleksandra, additional, Porter, Tarryn, additional, Mazzeo, Cecilia Icoresi, additional, van Dongen, Stijn, additional, Dabrowska, Monika, additional, Vaskivskyi, Vasyl, additional, Mahbubani, Krishnaa T., additional, Park, Jong-eun, additional, Jimenez-Linan, Mercedes, additional, Campos, Lia, additional, Kiselev, Vladimir Yu., additional, Lindskog, Cecilia, additional, Ayuk, Paul, additional, Prigmore, Elena, additional, Stratton, Michael R., additional, Saeb-Parsy, Kourosh, additional, Moffett, Ashley, additional, Moore, Luiza, additional, Bayraktar, Omer A., additional, Teichmann, Sarah A., additional, Turco, Margherita Y., additional, and Vento-Tormo, Roser, additional

Published
2022
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10. Viscoelastometry guided fresh frozen plasma infusion for postpartum haemorrhage: OBS2, an observational study

Author

Collins, P. W., Cannings-John, R., Bruynseels, D., Mallaiah, S., Dick, J., Elton, C., Weeks, A., Sanders, J., Aawar, N., Townson, J., Hood, K., Hall, J., Harding, K., Gauntlett, R., Collis, R., Rees, Alexandra, Edey, Tracey, Millett, Miranda, Ridgway, Anouk, Jones, Rhidian, Leslie, David, Bell, Sarah, MacLeod, Natalia, Kealaher, Emma, Hamlyn, Vincent, Merrett, Laura, Maybury, Helena, Dickens, Joanne, Peck, Katie, Paterson, Molly, Lack, Nicki, Fernando, Roshan, Messina, Chiara, Shellabear, Mikala, Mon, Wint Yu, Husain, Toc, Patel, Selina, Reeve, Alexandra, O’Brien, Ediri, Cunningham, Caroline, O’Keefe, Rachel, McNamara, Helen, Dower, Michelle, Diab, Falak, Holt, Siobhan, Houghton, Gill, Kerrigan, Angela, Scott, Jason, Fetherstone, Jenie, Uddin, Zeenath, Gonkatsang, Namgyal, Ayuk, Paul, Fenn, Andrea, Paranjothy, Shantini, Moody, Gwenllian, Poile, Vincent, Espinasse, Aude, and Evans, Judith

Published
2017
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12. Author Correction: Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

Author

Garcia-Alonso, Luz, Handfield, Louis-François, Roberts, Kenny, Nikolakopoulou, Konstantina, Fernando, Ridma C., Gardner, Lucy, Woodhams, Benjamin, Arutyunyan, Anna, Polanski, Krzysztof, Hoo, Regina, Sancho-Serra, Carmen, Li, Tong, Kwakwa, Kwasi, Tuck, Elizabeth, Lorenzi, Valentina, Massalha, Hassan, Prete, Martin, Kleshchevnikov, Vitalii, Tarkowska, Aleksandra, Porter, Tarryn, Mazzeo, Cecilia Icoresi, van Dongen, Stijn, Dabrowska, Monika, Vaskivskyi, Vasyl, Mahbubani, Krishnaa T., Park, Jong-eun, Jimenez-Linan, Mercedes, Campos, Lia, Kiselev, Vladimir Yu., Lindskog, Cecilia, Ayuk, Paul, Prigmore, Elena, Stratton, Michael R., Saeb-Parsy, Kourosh, Moffett, Ashley, Moore, Luiza, Bayraktar, Omer A., Teichmann, Sarah A., Turco, Margherita Y., Vento-Tormo, Roser, Garcia-Alonso, Luz, Handfield, Louis-François, Roberts, Kenny, Nikolakopoulou, Konstantina, Fernando, Ridma C., Gardner, Lucy, Woodhams, Benjamin, Arutyunyan, Anna, Polanski, Krzysztof, Hoo, Regina, Sancho-Serra, Carmen, Li, Tong, Kwakwa, Kwasi, Tuck, Elizabeth, Lorenzi, Valentina, Massalha, Hassan, Prete, Martin, Kleshchevnikov, Vitalii, Tarkowska, Aleksandra, Porter, Tarryn, Mazzeo, Cecilia Icoresi, van Dongen, Stijn, Dabrowska, Monika, Vaskivskyi, Vasyl, Mahbubani, Krishnaa T., Park, Jong-eun, Jimenez-Linan, Mercedes, Campos, Lia, Kiselev, Vladimir Yu., Lindskog, Cecilia, Ayuk, Paul, Prigmore, Elena, Stratton, Michael R., Saeb-Parsy, Kourosh, Moffett, Ashley, Moore, Luiza, Bayraktar, Omer A., Teichmann, Sarah A., Turco, Margherita Y., and Vento-Tormo, Roser

Published
2022
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15. Cell salvage and donor blood transfusion during cesarean section: A pragmatic, multicentre randomised controlled trial (SALVO)

Author

Khan, Khalid S., Moore, Philip A. S., Wilson, Matthew J., Hooper, Richard, Allard, Shubha, Wrench, Ian, Beresford, Lee, Roberts, Tracy E., McLoughlin, Carol, Geoghegan, James, Daniels, Jane P., Catling, Sue, Clark, Vicki A., Ayuk, Paul, Robson, Stephen, Gao-Smith, Fang, Hogg, Matthew, Lanz, Doris, and Dodds, Julie

Subjects
Blood transfusion -- Analysis -- Methods, Cesarean section -- Analysis -- Patient outcomes -- Physiological aspects, Biological sciences
Abstract

Background Excessive haemorrhage at cesarean section requires donor (allogeneic) blood transfusion. Cell salvage may reduce this requirement. Methods and findings We conducted a pragmatic randomised controlled trial (at 26 obstetric units; participants recruited from 4 June 2013 to 17 April 2016) of routine cell salvage use (intervention) versus current standard of care without routine salvage use (control) in cesarean section among women at risk of haemorrhage. Randomisation was stratified, using random permuted blocks of variable sizes. In an intention-to-treat analysis, we used multivariable models, adjusting for stratification variables and prognostic factors identified a priori, to compare rates of donor blood transfusion (primary outcome) and fetomaternal haemorrhage [greater than or equal to]2 ml in RhD-negative women with RhD-positive babies (a secondary outcome) between groups. Among 3,028 women randomised (2,990 analysed), 95.6% of 1,498 assigned to intervention had cell salvage deployed (50.8% had salvaged blood returned; mean 259.9 ml) versus 3.9% of 1,492 assigned to control. Donor blood transfusion rate was 3.5% in the control group versus 2.5% in the intervention group (adjusted odds ratio [OR] 0.65, 95% confidence interval [CI] 0.42 to 1.01, p = 0.056; adjusted risk difference -1.03, 95% CI -2.13 to 0.06). In a planned subgroup analysis, the transfusion rate was 4.6% in women assigned to control versus 3.0% in the intervention group among emergency cesareans (adjusted OR 0.58, 95% CI 0.34 to 0.99), whereas it was 2.2% versus 1.8% among elective cesareans (adjusted OR 0.83, 95% CI 0.38 to 1.83) (interaction p = 0.46). No case of amniotic fluid embolism was observed. The rate of fetomaternal haemorrhage was higher with the intervention (10.5% in the control group versus 25.6% in the intervention group, adjusted OR 5.63, 95% CI 1.43 to 22.14, p = 0.013). We are unable to comment on long-term antibody sensitisation effects. Conclusions The overall reduction observed in donor blood transfusion associated with the routine use of cell salvage during cesarean section was not statistically significant. Trial registration This trial was prospectively registered on ISRCTN as trial number 66118656 and can be viewed on http://www.isrctn.com/ISRCTN66118656., Author(s): Khalid S. Khan 1,*, Philip A. S. Moore 2, Matthew J. Wilson 3, Richard Hooper 4, Shubha Allard 5, Ian Wrench 6, Lee Beresford 4, Tracy E. Roberts 7, [...]

Published
2017
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19. Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

Author

Garcia-Alonso, Luz, primary, Handfield, Louis-François, additional, Roberts, Kenny, additional, Nikolakopoulou, Konstantina, additional, Fernando, Ridma C., additional, Gardner, Lucy, additional, Woodhams, Ben, additional, Arutyunyan, Anna, additional, Polanski, Krzysztof, additional, Hoo, Regina, additional, Sancho-Serra, Carmen, additional, Li, Tong, additional, Kwakwa, Kwasi, additional, Tuck, Elizabeth, additional, Kleshchevnikov, Vitalii, additional, Tarkowska, Aleksandra, additional, Porter, Tarryn, additional, Mazzeo, Cecilia Icoresi, additional, van Dongen, Stijn, additional, Dabrowska, Monika, additional, Vaskivskyi, Vasyl, additional, Mahbubani, Krishna T., additional, Park, Jong-eun, additional, Jimenez-Linan, Mercedes, additional, Campos, Lia, additional, Kiselev, Vladimir, additional, Lindskog, Cecilia, additional, Ayuk, Paul, additional, Prigmore, Elena, additional, Stratton, Michael R, additional, Saeb-Parsy, Kourosh, additional, Moffett, Ashley, additional, Moore, Luiza, additional, Bayraktar, Omer A., additional, Teichmann, Sarah A., additional, Turco, Margherita Y., additional, and Vento-Tormo, Roser, additional

Published
2021
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25. Cost-effectiveness of cell salvage and donor blood transfusion during caesarean section: results from a randomised controlled trial

Author

McLoughlin, Carol, primary, Roberts, Tracy E, additional, Jackson, Louise J, additional, Moore, Philip, additional, Wilson, Matthew, additional, Hooper, Richard, additional, Allard, Shubha, additional, Wrench, Ian, additional, Beresford, Lee, additional, Geoghegan, James, additional, Daniels, Jane, additional, Catling, Sue, additional, Clark, Vicki A, additional, Ayuk, Paul, additional, Robson, Stephen, additional, Gao-Smith, Fang, additional, Hogg, Matthew, additional, Lanz, Doris, additional, Dodds, Julie, additional, and Khan, Khalid S, additional

Published
2019
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28. A randomised controlled trial and economic evaluation of intraoperative cell salvage during caesarean section in women at risk of haemorrhage: the SALVO (cell SALVage in Obstetrics) trial

Author

Khan, Khalid S, primary, Moore, Philip, additional, Wilson, Matthew, additional, Hooper, Richard, additional, Allard, Shubha, additional, Wrench, Ian, additional, Roberts, Tracy, additional, McLoughlin, Carol, additional, Beresford, Lee, additional, Geoghegan, James, additional, Daniels, Jane, additional, Catling, Sue, additional, Clark, Vicki A, additional, Ayuk, Paul, additional, Robson, Stephen, additional, Gao-Smith, Fang, additional, Hogg, Matthew, additional, Jackson, Louise, additional, Lanz, Doris, additional, and Dodds, Julie, additional

Published
2018
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30. Development and polarization of cationic amino acid transporters and regulators in the human placenta

Author

AYUK, PAUL T.-Y., SIBLEY, COLIN P., DONNAI, PAUL, D'SOUZA, STEPHEN, and GLAZIER, JOCELYN D.

Subjects
Arginine -- Research, Physiology -- Research, Amino acids -- Research, Biological sciences
Abstract

Ayuk, Paul T.-Y., Colin P. Sibley, Paul Donnai, Stephen D'Souza, and Jocelyn D. Glazier. Development and polarization of cationic amino acid transporters and regulators in the human placenta. Am J Physiol Cell Physiol 278: C1162-C1171, 2000.--We have investigated L-arginine transport systems in the human placental syncytiotrophoblast across gestation using purified microvillous (MVM) and basal (BM) plasma membrane vesicles. In MVM from first-trimester and term placentas, L-arginine transport was by systems [y.sup.+] and [y.sup.+]L. In BM (term placentas), however, there was evidence for system [y.sup.+]L only. The Michaelis constant of system [y.sup.+]L was significantly lower (P [is less than] 0.05) in first-trimester compared with term MVM and lower in term MVM compared with BM (P [is less than] 0.05). There was no functional evidence for system [b.sup.0+] in term MVM or BM. Cationic amino acid transporter (CAT) 1, CAT 4, and 4F2hc were detected using RT-PCR in placentas throughout gestation, rBAT was not detected in term placentas. An ~85-kDa and an ~135-kDa protein was detected by Western blotting in MVM under reducing and nonreducing conditions, respectively, consistent with the 4F2hc monomer and the 4F2hc-light chain dimer, and their expression was significantly higher (P [is less than] 0.05) in term compared with first-trimester MVM. These proteins were not detected in BM despite functional evidence for system [y.sup.+]L. These data suggest different roles for 4F2hc in the development and polarization of cationic amino acid transporters in the syncytiotrophoblast. CAT 1; CAT 4; 4F2hc; rBAT; L-arginine; gestational change

Published
2000

31. LB01: Cell Salvage during Caesarean Section: A Randomised Controlled Trial (The SALVO Trial)

Author

Khan, Khalid, primary, Moore, Philip, additional, Wilson, Matthew J., additional, Hooper, Richard, additional, Allard, Shubha, additional, Wrench, Ian, additional, Beresford, Lee, additional, Roberts, Tracy, additional, McLoughlin, Carol, additional, Geoghegan, James, additional, Daniels, Jane P., additional, Catling, Sue, additional, Clark, Vicki A., additional, Ayuk, Paul, additional, Robson, Stephen, additional, Gao-Smith, Fang, additional, Hogg, Matthew, additional, Lanz, Doris, additional, and Dodds, Julie, additional

Published
2017
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34. Placental ischaemia is a consequence rather than a cause of pre-eclampsia

Author

Ayuk, Paul and Matijević, Ratko

Subjects
pre eclampsia, placental ischaemia, embryonic structures, female genital diseases and pregnancy complications, reproductive and urinary physiology
Abstract

The aetiology or pre-eclampsia remains unknown, but it is widely accepted that the disorder is placental in origin. Failed trophoblast invasion of the maternal spiral arteries is accepted to be a central pathogenetic mechanism. However, the concept of failed trophoblast invasion is based on an assumption rather than direct scientific observation and there are other likely explanations for this phenomenon. The criteria for disease causation, such as the Bradford-Hill criteria are central to the ascertainment of causal relationships in modern medicine and these criteria are used here to assess the relationship between the placenta and pre-eclampsia. There is a strong association between pre-eclampsia and small (rather than large) placentas and an appropriate dose-response relationship does not exist. Failed trophoblast invasion of the spiral arteries is not specific to pre-eclampsia and occurs in other pregnancy complications and in up to 40% of biopsies from normal pregnancies and the relationship between placental ischaemia and pre-eclampsia is very inconsistent. A placental cause for pre-eclampsia is not consistent with the pathogenesis of other pregnancy complications like gestational diabetes mellitus. If pre-eclampsia was a disease of trophoblast origin, the risk of the disease should be determined by trophoblast rather than maternal factors. However, evidence from assisted reproduction shows that the risk of a woman developing pre-eclampsia is almost entirely dependent on maternal factors and independent of the embryo from which the placenta develops. There is currently no plausible proven mechanism by which the placenta causes pre-eclampsia. The syndrome typically gets worse, and can arise de-novo after the placenta has been removed, calling into question the role of the placenta in its causation. Uterine artery ligation in humans, unlike in animal experiments, is not associated with an increased incidence of pre-eclampsia, calling into question the role of poor utero-placental perfusion in the cause of the disease in humans. The signals that initiate maternal adaptive responses during pregnancy come from or through the placenta into the maternal milieu but as is the case with gestational diabetes mellitus, are not necessarily the cause of maternal disease. Pre-eclampsia causes renal, hepatic, myocardial, cerebral and adrenal ischaemia--that is ischaemia in all highly vascular organs. Placental ischaemia, like ischaemia in all other organs, is a consequence rather than a causal factor in the development of the syndrome and this has profound consequences for research strategies.

Published
2006

36. Placental Phenotypes of Intrauterine Growth

Author

Sibley, Colin P, primary, Turner, Mark A, additional, Cetin, Irene, additional, Ayuk, Paul, additional, Boyd, C A Richard, additional, D'Souza, Stephen W, additional, Glazier, Jocelyn D, additional, Greenwood, Susan L, additional, Jansson, Thomas, additional, and Powell, Theresa, additional

Published
2005
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37. System y+ arginine transport and NO production in peripheral blood mononuclear cells in pregnancy and preeclampsia.

Author

McCord N, Ayuk P, McMahon M, Boyd RC, Sargent I, and Redman C

Subjects
Adult, Amino Acid Transport Systems, Basic, Arginine pharmacokinetics, Case-Control Studies, Cationic Amino Acid Transporter 1 genetics, Cationic Amino Acid Transporter 2 genetics, Female, Humans, Kinetics, Nitric Oxide Synthase Type II biosynthesis, Nitric Oxide Synthase Type III biosynthesis, Pregnancy Trimester, Third, RNA, Messenger metabolism, Amino Acid Transport System y+ metabolism, Monocytes metabolism, Nitric Oxide biosynthesis, Pre-Eclampsia blood, Pregnancy blood
Abstract

Systemic inflammation and oxidative stress are features of normal pregnancy and, in excess, contribute to the pathogenesis of preeclampsia. Inflammatory cell activation stimulates uptake of arginine (the precursor for nitric oxide) by transport system y+, expression of one of its genes (CAT-2) together with inducible nitric oxide synthase, leading to nitric oxide production. We investigated whether these changes occur in peripheral blood mononuclear cells in normal pregnancy and are exaggerated in preeclampsia. Samples from matched trios of nonpregnant, normal pregnant, and preeclamptic women were studied. Arginine transport was characterized, and the expression of inducible nitric oxide synthase and cell-specific nitric oxide production were measured. Arginine uptake by system y+ was significantly increased (P<0.001) in peripheral blood mononuclear cells in normal pregnancy but not in preeclampsia. CAT-2 mRNA was not detected in cells from nonpregnant women but was detected in 3 of 10 normal pregnant and 8 of 10 of preeclamptic women (P<0.001). Inducible nitric oxide synthase protein expression was significantly increased in normal pregnant women (P<0.05) but not preeclamptic women. No significant differences in cell-specific nitric oxide production were observed. These changes confirm the predictions for normal pregnancy but not for preeclampsia in which, despite increases in CAT-2 expression, arginine uptake is not additionally increased. This may create a relative deficiency of arginine in PBMCs favoring superoxide and peroxynitrite production and contribute to oxidative and nitrosative stress in preeclampsia.

Published
2006
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