1. Assessment of brachial artery reactivity, carotid intima-media thickness, and adhesion molecules in pediatric solid tumor patients treated with anthracyclines
- Author
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Aynur Oguz, Faruk Güçlü Pınarlı, Arzu Aral, Suna Özhan Oktar, Ceyda Karadeniz, and Arzu Okur
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pathology ,Adolescent ,Brachial Artery ,Anthracycline ,Intercellular Adhesion Molecule-1 ,Urology ,Vascular Cell Adhesion Molecule-1 ,030204 cardiovascular system & hematology ,Carotid Intima-Media Thickness ,03 medical and health sciences ,0302 clinical medicine ,Neoplasms ,medicine.artery ,E-selectin ,medicine ,Humans ,Anthracyclines ,Doxorubicin ,Brachial artery ,Endothelial dysfunction ,Child ,biology ,business.industry ,Cell adhesion molecule ,Hematology ,medicine.disease ,Oncology ,Intima-media thickness ,Child, Preschool ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,biology.protein ,Female ,E-Selectin ,business ,Cell Adhesion Molecules ,medicine.drug - Abstract
The aim of this study was to determine subclinical atherosclerosis and endothelial functional disturbance with measurement of carotid intima-media thickness (IMT), brachial artery reactivity (BAR), and levels of serum adhesion molecules in children with solid tumors who were treated with anthracyclines and are actually in complete remission. Fifty patients who were in remission and 30 healthy children were included in the study. Mean ages of patient and control groups were 13.5 +/- 4.7 years (range: 3-23 years) and 12.00 +/- 4.3 years (range: 4-21 years), respectively. The patients were divided into 3 groups according to cumulative doxorubicin dose: Group 1, = 300 mg/m(2). The BAR and carotid IMT were measured in order to determine the endothelial function. The serum adhesion molecule levels in our patients and controls were also measured. The BAR of the patients with cumulative anthracycline dose >= 300 mg/m(2) was significantly lower than the patients with cumulative anthracycline dose
- Published
- 2016