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Objective: To demonstrate treatment responses, survival analysis and treatment-related mortality characteristics of patients with malignant somatic transformation (MST). Materials and Methods: In this retrospective cross-sectional study, patients with relapsed and refractory MST who had previously received multiple-line chemotherapy were evaluated. Clinical features and follow-up data of relapsed/refractory MST patients were recorded from the patients’ registration database at the hospital. Age, clinical stage at initial diagnosis, serum tumour marker levels, visceral metastasis status, previous treatment protocols and follow-up times were recorded. This study aims to demonstrate demographic and disease-related characteristics, best response to systemic therapy, and overall survival (OS) results. Results: The study included 14 patients. Mean age at diagnosis was 29.6 years for the whole group. The most-common sarcoma subtype was Ewing sarcoma (44.4% in the sarcoma group). In half the patients, the best response to systemic treatment was determined as a complete response. Median OS for the sarcoma group was 19.72 months [interquartile range (IQR) 29.18 months], and in the adenocarcinoma group, it was determined as 136.24 months (IQR 131.92 months) (p=0.006). The median OS for the whole group was 28.12 months (IQR 99 months). No significant difference in survival was found between synchronous and relapsed cases [median (IQR) 24.09 (91.23) months vs 43.54 (113.51) months, p=0.606]. Conclusions: Germ cell tumour patients with MST should be treated according to the somatic component. Poor responses to cisplatin-based chemotherapy have been found in this cohort. Patients with sarcomatous components were found to have significantly shorter OS. [ABSTRACT FROM AUTHOR]

Objective: Sepsis is a dysregulated systemic inflammatory and oxidative response to infection. Thiol-disulfide homeostasis (TDH) has a crucial role in the protection from oxidative stress and is a reliable indicator of oxidative stress. Furthermore, ischemia-modified albumin (IMA) is an indicator of oxidative-stress-related tissue damage. In this study, we determined the predictive value of TDH and IMA on 28-day mortality in patients undergoing sepsis. Materials and Methods: We collected blood samples from adult patients undergoing sepsis at the time of admission to the intensive care unit to determine TDH and IMA levels. Concurrently, we calculated Sequential Organ Failure Assessment (SOFA) scores to weigh the severity of sepsis. Moreover, we followed up the patients for 28-day intra-hospital mortality. We statistically analyzed the study parameters of the patients in both the survivor and non-survivor groups. Results: Forty-six patients with sepsis were enrolled. Among them, 27 survived at the end of the 28-day follow-up period. The mean age of the patients was 73.07±13.87 years, and 43.5% of them were female. The mean SOFA score was significantly higher in the non-survivor group (p<0.05). However, no significant differences in the total thiol, native thiol, disulfide, and IMA levels at baseline were observed between the survivor and non-survivor groups (p>0.05 for all). Receiver operator characteristics (ROC) and area under the curve (AUC) analysis revealed that IMA and thiol parameters had no predictive power on the survival of patients with sepsis. Conclusion: This study showed that baseline TDH parameters and IMA levels were not significantly different between survivors and non-survivors of sepsis and were not related to the prediction of mortality. [ABSTRACT FROM AUTHOR]

Retroperitoneal fibrosis is a rare disease and characterized by the presence of fibrous and inflammatory retroperitoneal tissue. Fluorine-18-fluorodeoxyglucose positron emission tomography (FDG/PET) is a beneficial methods for inflammatory dieseases. We presented here a case of 40 year old woman with idiopathic retroperitoenal fibrosis which detected high SUVmax level (21.4) on FDG/PET and had high erythrocyte sedimentatiton rate (140mm/h). If high SUVmax is detected, histologic confirmation is necessary to exclude malignancies [ABSTRACT FROM AUTHOR]