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2. Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa

Author

Zhou, Weiyin, Fischer, Anja, Ogwang, Martin D., Luo, Wen, Kerchan, Patrick, Reynolds, Steven J., Tenge, Constance N., Were, Pamela A., Kuremu, Robert T., Wekesa, Walter N., Masalu, Nestory, Kawira, Esther, Kinyera, Tobias, Otim, Isaac, Legason, Ismail D., Nabalende, Hadijah, Ayers, Leona W., Bhatia, Kishor, Goedert, James J., Gouveia, Mateus H., Cole, Nathan, Hicks, Belynda, Jones, Kristine, Hummel, Michael, Schlesner, Mathias, Chagaluka, George, Mutalima, Nora, Borgstein, Eric, Liomba, George N., Kamiza, Steve, Mkandawire, Nyengo, Mitambo, Collins, Molyneux, Elizabeth M., Newton, Robert, Glaser, Selina, Kretzmer, Helene, Manning, Michelle, Hutchinson, Amy, Hsing, Ann W., Tettey, Yao, Adjei, Andrew A., Chanock, Stephen J., Siebert, Reiner, Yeager, Meredith, Prokunina-Olsson, Ludmila, Machiela, Mitchell J., and Mbulaiteye, Sam M.

Published
2023
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3. Mast Cell Activation and KSHV Infection in Kaposi Sarcoma

Author

Ayers, Leona W, Barbachano-Guerrero, Arturo, McAllister, Shane C, Ritchie, Julie A, Asiago-Reddy, Elizabeth, Bartlett, Linda C, Cesarman, Ethel, Wang, Dongliang, Rochford, Rosemary, Martin, Jeffrey N, and King, Christine A

Subjects
Biomedical and Clinical Sciences, Immunology, Rare Diseases, Sexually Transmitted Infections, Infectious Diseases, HIV/AIDS, Cancer, Emerging Infectious Diseases, 2.1 Biological and endogenous factors, Aetiology, Infection, Good Health and Well Being, Adult, Aged, Aged, 80 and over, Biomarkers, Cytokines, Disease Susceptibility, Female, Herpesviridae Infections, Herpesvirus 8, Human, Humans, Immunohistochemistry, Male, Mast Cells, Methylhistamines, Middle Aged, Models, Biological, Sarcoma, Kaposi, Skin, Tryptases, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

Purpose: Kaposi sarcoma (KS) is a vascular tumor initiated by infection of endothelial cells (ECs) with KS-associated herpesvirus (KSHV). KS is dependent on sustained proinflammatory signals provided by intralesional leukocytes and continued infection of new ECs. However, the sources of these cytokines and infectious virus within lesions are not fully understood. Here, mast cells (MCs) are identified as proinflammatory cells within KS lesions that are permissive for, and activated by, infection with KSHV.Experimental Design: Three validated MC lines were used to assess permissivity of MCs to infection with KSHV and to evaluate MCs activation following infection. Biopsies from 31 AIDS-KS cases and 11 AIDS controls were evaluated by IHC for the presence of MCs in KS lesions and assessment of MC activation state and infection with KSHV. Plasma samples from 26 AIDS-KS, 13 classic KS, and 13 healthy adults were evaluated for levels of MC granule contents tryptase and histamine.Results: In culture, MCs supported latent and lytic KSHV infection, and infection-induced MC degranulation. Within KS lesions, MCs were closely associated with spindle cells. Furthermore, MC activation was extensive within patients with KS, reflected by elevated circulating levels of tryptase and a histamine metabolite. One patient with clinical signs of extensive MC activation was treated with antagonists of MC proinflammatory mediators, which resulted in a rapid and durable regression of AIDS-KS lesions.Conclusions: Using complimentary in vitro and in vivo studies we identify MCs as a potential long-lived reservoir for KSHV and a source of proinflammatory mediators within the KS lesional microenvironment. In addition, we identify MC antagonists as a promising novel therapeutic approach for KS. Clin Cancer Res; 24(20); 5085-97. ©2018 AACR.

Published
2018

4. Endemic Burkitt Lymphoma in second-degree relatives in Northern Uganda: in-depth genome-wide analysis suggests clues about genetic susceptibility

Author

Gouveia, Mateus H., Otim, Isaac, Ogwang, Martin D., Wang, Mingyi, Zhu, Bin, Cole, Nathan, Luo, Wen, Hicks, Belynda, Jones, Kristine, Oehl-Huber, Kathrin, Ayers, Leona W., Pittaluga, Stefania, Legason, Ismail D., Nabalende, Hadijah, Kerchan, Patrick, Kinyera, Tobias, Kawira, Esther, Brubaker, Glen, Levin, Arthur G., Guertler, Lutz, Kim, Jung, Stewart, Douglas R., Adde, Melissa, Magrath, Ian, Bergen, Andrew W., Reynolds, Steven J., Yeager, Meredith, Bhatia, Kishor, Adeyemo, Adebowale A., Prokunina-Olsson, Ludmila, Dean, Michael, Shriner, Daniel, Rotimi, Charles N., Chanock, Stephen, Siebert, Reiner, and Mbulaiteye, Sam M.

Published
2021
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5. Human leukocyte antigen-DQA1*04:01 and rs2040406 variants are associated with elevated risk of childhood Burkitt lymphoma

Author

Liu, Zhiwei, primary, Luo, Yang, additional, Kirimunda, Samuel, additional, Verboom, Murielle, additional, Onabajo, Olusegun O., additional, Gouveia, Mateus H., additional, Ogwang, Martin D., additional, Kerchan, Patrick, additional, Reynolds, Steven J., additional, Tenge, Constance N., additional, Were, Pamela A., additional, Kuremu, Robert T., additional, Wekesa, Walter N., additional, Masalu, Nestory, additional, Kawira, Esther, additional, Kinyera, Tobias, additional, Otim, Isaac, additional, Legason, Ismail D., additional, Nabalende, Hadijah, additional, Dhudha, Herry, additional, Ayers, Leona W., additional, Bhatia, Kishor, additional, Goedert, James J., additional, Cole, Nathan, additional, Luo, Wen, additional, Liu, Jia, additional, Manning, Michelle, additional, Hicks, Belynda, additional, Prokunina-Olsson, Ludmila, additional, Chagaluka, George, additional, Johnston, W. Thomas, additional, Mutalima, Nora, additional, Borgstein, Eric, additional, Liomba, George N., additional, Kamiza, Steve, additional, Mkandawire, Nyengo, additional, Mitambo, Collins, additional, Molyneux, Elizabeth M., additional, Newton, Robert, additional, Hsing, Ann W., additional, Mensah, James E., additional, Adjei, Anthony A., additional, Hutchinson, Amy, additional, Carrington, Mary, additional, Yeager, Meredith, additional, Blasczyk, Rainer, additional, Chanock, Stephen J., additional, Raychaudhuri, Soumya, additional, and Mbulaiteye, Sam M., additional

Published
2024
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6. Sickle cell allele HBB‐rs334(T) is associated with decreased risk of childhood Burkitt lymphoma in East Africa

Author

Hong, Hyokyoung G., primary, Gouveia, Mateus H., additional, Ogwang, Martin D., additional, Kerchan, Patrick, additional, Reynolds, Steven J., additional, Tenge, Constance N., additional, Were, Pamela A., additional, Kuremu, Robert T., additional, Wekesa, Walter N., additional, Masalu, Nestory, additional, Kawira, Esther, additional, Kinyera, Tobias, additional, Wang, Xunde, additional, Zhou, Jiefu, additional, Leal, Thiago Peixoto, additional, Otim, Isaac, additional, Legason, Ismail D., additional, Nabalende, Hadijah, additional, Dhudha, Herry, additional, Mumia, Mediatrix, additional, Baker, Francine S., additional, Okusolubo, Temiloluwa, additional, Ayers, Leona W., additional, Bhatia, Kishor, additional, Goedert, James J., additional, Woo, Joshua, additional, Manning, Michelle, additional, Cole, Nathan, additional, Luo, Wen, additional, Hicks, Belynda, additional, Chagaluka, George, additional, Johnston, W. Thomas, additional, Mutalima, Nora, additional, Borgstein, Eric, additional, Liomba, George N., additional, Kamiza, Steve, additional, Mkandawire, Nyengo, additional, Mitambo, Collins, additional, Molyneux, Elizabeth M., additional, Newton, Robert, additional, Hutchinson, Amy, additional, Yeager, Meredith, additional, Adeyemo, Adebowale A., additional, Thein, Swee Lay, additional, Rotimi, Charles N., additional, Chanock, Stephen J., additional, Prokunina‐Olsson, Ludmila, additional, and Mbulaiteye, Sam M., additional

Published
2023
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7. Inverse association of falciparum positivity with endemic Burkitt lymphoma is robust in analyses adjusting for pre-enrollment malaria in the EMBLEM case-control study

Author

Peprah, Sally, Ogwang, Martin D., Kerchan, Patrick, Reynolds, Steven J., Tenge, Constance N., Were, Pamela A., Kuremu, Robert T., Wekesa, Walter N., Masalu, Nestory, Kawira, Esther, Otim, Isaac, Legason, Ismail D., Ayers, Leona W., Bhatia, Kishor, Goedert, James J., Pfeiffer, Ruth M., and Mbulaiteye, Sam M.

Published
2021
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8. The emergence of SARS-CoV-2 lineages and associated saliva antibody responses among asymptomatic individuals in a large university community

Author

Merling, Marlena R., primary, Williams, Amanda, additional, Mahfooz, Najmus S., additional, Ruane-Foster, Marisa, additional, Smith, Jacob, additional, Jahnes, Jeff, additional, Ayers, Leona W., additional, Bazan, Jose A., additional, Norris, Alison, additional, Norris Turner, Abigail, additional, Oglesbee, Michael, additional, Faith, Seth A., additional, Quam, Mikkel B., additional, and Robinson, Richard T., additional

Published
2023
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9. Endemic Burkitt lymphoma: a complication of asymptomatic malaria in sub-Saharan Africa based on published literature and primary data from Uganda, Tanzania, and Kenya

Author

Redmond, Lawrence S., Ogwang, Martin D., Kerchan, Patrick, Reynolds, Steven J., Tenge, Constance N., Were, Pamela A., Kuremu, Robert T., Masalu, Nestory, Kawira, Esther, Otim, Isaac, Legason, Ismail D., Dhudha, Herry, Ayers, Leona W., Bhatia, Kishor, Goedert, James J., and Mbulaiteye, Sam M.

Published
2020
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10. The AIDS and Cancer Specimen Resource: Role in HIV/AIDS scientific discovery

Author

Ayers, Leona W, Silver, Sylvia, McGrath, Michael S, and Orenstein, Jan M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Infectious Diseases, Lymphoma, Cancer, HIV/AIDS, Clinical Research, Hematology, Rare Diseases, 2.1 Biological and endogenous factors, Detection, screening and diagnosis, 4.5 Resources and infrastructure (detection), Aetiology, Medical Microbiology, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

The AIDS Cancer and Specimen Resource (ACSR) supports scientific discovery in the area of HIV/AIDS-associated malignancies. The ACSR was established as a cooperative agreement between the NCI (Office of the Director, Division of Cancer Treatment and Diagnosis) and regional consortia, University of California, San Francisco (West Coast), George Washington University (East Coast) and Ohio State University (Mid-Region) to collect, preserve and disperse HIV-related tissues and biologic fluids and controls along with clinical data to qualified investigators. The available biological samples with clinical data and the application process are described on the ACSR web site. The ACSR tissue bank has more than 100,000 human HIV positive specimens that represent different processing (43), specimen (15), and anatomical site (50) types. The ACSR provides special biospecimen collections and prepares speciality items, e.g., tissue microarrays (TMA), DNA libraries. Requests have been greatest for Kaposi's sarcoma (32%) and non-Hodgkin's lymphoma (26%). Dispersed requests include 83% tissue (frozen and paraffin embedded), 18% plasma/serum and 9% other. ACSR also provides tissue microarrays of, e.g., Kaposi's sarcoma and non-Hodgkin's lymphoma, for biomarker assays and has developed collaborations with other groups that provide access to additional AIDS-related malignancy specimens. ACSR members and associates have completed 63 podium and poster presentations. Investigators have submitted 125 letters of intent requests. Discoveries using ACSR have been reported in 61 scientific publications in notable journals with an average impact factor of 7. The ACSR promotes the scientific exploration of the relationship between HIV/AIDS and malignancy by participation at national and international scientific meetings, contact with investigators who have productive research in this area and identifying, collecting, preserving, enhancing, and dispersing HIV/AIDS-related malignancy specimens to funded, approved researchers at no fee. Scientific discovery has been advanced by this unique biorepository. Investigators are encouraged to browse the ACSR Internet site for materials to enhance their own scientific initiatives.

Published
2007

12. Supplementary Figure Legends from MicroRNA-31 Predicts the Presence of Lymph Node Metastases and Survival in Patients with Lung Adenocarcinoma

Author

Meng, Wei, primary, Ye, Zhenqing, primary, Cui, Ri, primary, Perry, James, primary, Dedousi-Huebner, Vaia, primary, Huebner, Alexander, primary, Wang, Yao, primary, Li, Bin, primary, Volinia, Stefano, primary, Nakanishi, Hiroshi, primary, Kim, Taewan, primary, Suh, Sung-Suk, primary, Ayers, Leona W., primary, Ross, Patrick, primary, Croce, Carlo M., primary, Chakravarti, Arnab, primary, Jin, Victor X., primary, and Lautenschlaeger, Tim, primary

Published
2023
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13. Supplementary Figures from MicroRNA-31 Predicts the Presence of Lymph Node Metastases and Survival in Patients with Lung Adenocarcinoma

Author

Meng, Wei, primary, Ye, Zhenqing, primary, Cui, Ri, primary, Perry, James, primary, Dedousi-Huebner, Vaia, primary, Huebner, Alexander, primary, Wang, Yao, primary, Li, Bin, primary, Volinia, Stefano, primary, Nakanishi, Hiroshi, primary, Kim, Taewan, primary, Suh, Sung-Suk, primary, Ayers, Leona W., primary, Ross, Patrick, primary, Croce, Carlo M., primary, Chakravarti, Arnab, primary, Jin, Victor X., primary, and Lautenschlaeger, Tim, primary

Published
2023
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14. Supplementary Tables from MicroRNA-31 Predicts the Presence of Lymph Node Metastases and Survival in Patients with Lung Adenocarcinoma

Author

Meng, Wei, primary, Ye, Zhenqing, primary, Cui, Ri, primary, Perry, James, primary, Dedousi-Huebner, Vaia, primary, Huebner, Alexander, primary, Wang, Yao, primary, Li, Bin, primary, Volinia, Stefano, primary, Nakanishi, Hiroshi, primary, Kim, Taewan, primary, Suh, Sung-Suk, primary, Ayers, Leona W., primary, Ross, Patrick, primary, Croce, Carlo M., primary, Chakravarti, Arnab, primary, Jin, Victor X., primary, and Lautenschlaeger, Tim, primary

Published
2023
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15. Table S1 from Mast Cell Activation and KSHV Infection in Kaposi Sarcoma

Author

Ayers, Leona W., primary, Barbachano-Guerrero, Arturo, primary, McAllister, Shane C., primary, Ritchie, Julie A., primary, Asiago-Reddy, Elizabeth, primary, Bartlett, Linda C., primary, Cesarman, Ethel, primary, Wang, Dongliang, primary, Rochford, Rosemary, primary, Martin, Jeffrey N., primary, and King, Christine A., primary

Published
2023
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16. Figure S1 from Mast Cell Activation and KSHV Infection in Kaposi Sarcoma

Author

Ayers, Leona W., primary, Barbachano-Guerrero, Arturo, primary, McAllister, Shane C., primary, Ritchie, Julie A., primary, Asiago-Reddy, Elizabeth, primary, Bartlett, Linda C., primary, Cesarman, Ethel, primary, Wang, Dongliang, primary, Rochford, Rosemary, primary, Martin, Jeffrey N., primary, and King, Christine A., primary

Published
2023
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17. Author Correction to: Endemic Burkitt lymphoma in second-degree relatives in Northern Uganda: in-depth genome-wide analysis suggests clues about genetic susceptibility

Author

Gouveia, Mateus H., Otim, Isaac, Ogwang, Martin D., Wang, Mingyi, Zhu, Bin, Cole, Nathan, Luo, Wen, Hicks, Belynda, Jones, Kristine, Oehl-Huber, Kathrin, Ayers, Leona W., Pittaluga, Stefania, Legason, Ismail D., Nabalende, Hadijah, Kerchan, Patrick, Kinyera, Tobias, Kawira, Esther, Brubaker, Glen, Levin, Arthur G., Guertler, Lutz, Kim, Jung, Stewart, Douglas R., Adde, Melissa, Magrath, Ian, Bergen, Andrew W., Reynolds, Steven J., Yeager, Meredith, Bhatia, Kishor, Adeyemo, Adebowale A., Prokunina-Olsson, Ludmila, Dean, Michael, Shriner, Daniel, Rotimi, Charles N., Chanock, Stephen, Siebert, Reiner, and Mbulaiteye, Sam M.

Published
2021
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18. Burkitt lymphoma risk shows geographic and temporal associations with Plasmodium falciparum infections in Uganda, Tanzania, and Kenya

Author

Broen, Kelly, primary, Dickens, Joey, additional, Trangucci, Rob, additional, Ogwang, Martin D., additional, Tenge, Constance N., additional, Masalu, Nestory, additional, Reynolds, Steven J., additional, Kawira, Esther, additional, Kerchan, Patrick, additional, Were, Pamela A., additional, Kuremu, Robert T., additional, Wekesa, Walter N., additional, Kinyera, Tobias, additional, Otim, Isaac, additional, Legason, Ismail D., additional, Nabalende, Hadija, additional, Buller, Ian D., additional, Ayers, Leona W., additional, Bhatia, Kishor, additional, Biggar, Robert J., additional, Goedert, James J., additional, Wilson, Mark L., additional, Mbulaiteye, Sam M., additional, and Zelner, Jon, additional

Published
2023
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19. Increased Frequency of Mosaic Chromosomal Alterations in Peripheral Blood Samples of Sub-Saharan African Children with Endemic Burkitt Lymphoma

Author

Zhou, Weiyin, primary, Pfaus, Anja, additional, Ogwang, Martin, additional, Luo, Wen, additional, Kerchan, Patrick, additional, Reynolds, Steven, additional, Tenge, Constance N, additional, Were, Pamela A, additional, Kuremu, Robert T, additional, Wekesa, Walter N, additional, Masalu, Nestory, additional, Kawira, Esther, additional, Kinyera, Tobias, additional, Otim, Isaac, additional, Legason, Ismail D, additional, Nabalende, Hadijah, additional, Ayers, Leona W, additional, Bhatia, Kishor, additional, Goedert, James J, additional, Cole, Nathan, additional, Hicks, Belynda, additional, Jones, Kristine, additional, Hummel, Michael, additional, Schlesner, Matthias, additional, Chagaluka, George, additional, Mutalima, Nora, additional, Borgstein, Eric, additional, Liomba, George N, additional, Kamiza, Steve, additional, Mkandawire, Nyengo, additional, Mitambo, Collins, additional, Molyneux, Elizabeth, additional, Newton, Robert, additional, Glaser, Selina, additional, Manning, Michelle, additional, Hutchinson, Amy, additional, Hsing, Ann W, additional, Tettey, Yao, additional, Adjei, Andrew Anthony, additional, Chanock, Stephen J., additional, Siebert, Reiner, additional, Yeager, Meredith, additional, Machiela, Mitchell, additional, and Mbulaiteye, Sam M., additional

Published
2022
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20. Human Leukocyte Antigen Contributes to Childhood Endemic Burkitt Lymphoma in Eastern Africa: A Case-Control Association Study

Author

Liu, Zhiwei, primary, Luo, Yang, additional, Kirimunda, Samuel, additional, Verboom, Murielle, additional, Onabajo, Olusegun O, additional, Gouveia, Mateus H, additional, Ogwang, Martin, additional, Kerchan, Patrick, additional, Reynolds, Steven, additional, Tenge, Constance N, additional, Were, Pamela A, additional, Kuremu, Robert T, additional, Wekesa, Walter N, additional, Masalu, Nestory, additional, Kawira, Esther, additional, Kinyera, Tobias, additional, Otim, Isaac, additional, Legason, Ismail D, additional, Nabalende, Hadijah, additional, Dhudha, Herry, additional, Ayers, Leona W, additional, Biggar, Robert J, additional, Bhatia, Kishor G., additional, Goedert, James J, additional, Cole, Nathan, additional, Luo, Wen, additional, Liu, Jia, additional, Manning, Michelle, additional, Hicks, Belynda, additional, Prokunina-Olsson, Ludmila, additional, Chagaluka, George, additional, Johnston, Tom, additional, Mutalima, Nora, additional, Borgstein, Eric, additional, Liomba, George N, additional, Kamiza, Steve, additional, Mkandawire, Nyengo, additional, Mitambo, Collins, additional, Molyneux, Elizabeth, additional, Newton, Robert, additional, Hsing, Ann W, additional, Mensah, James E, additional, Pfeiffer, Ruth M, additional, Hutchinson, Amy, additional, Mary, Carrington, additional, Yeager, Meredith, additional, Joloba, Moses, additional, Blasczyk, Rainer, additional, Chanock, Stephen J., additional, Raychaudhuri, Soumya, additional, and Mbulaiteye, Sam M., additional

Published
2022
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21. HBB rs334, ABO R s8176703 and Plasmodium Falciparum Positivity at Enrollment Are Independently Associated with Lower Risk for Endemic Burkitt Lymphoma in Uganda, Tanzania, Kenya, and Malawi

Author

Hong, Hyokyoung G, primary, Gouveia, Mateus H, additional, Ogwang, Martin, additional, Kerchan, Patrick, additional, Reynolds, Steven, additional, Tenge, Constance N, additional, Were, Pamela A, additional, Kuremu, Robert T, additional, Wekesa, Walter N, additional, Masalu, Nestory, additional, Kawira, Esther, additional, Kinyera, Tobias, additional, Wang, Xunde, additional, Zhou, Jiefu, additional, Otim, Isaac, additional, Legason, Ismail D, additional, Nabalende, Hadijah, additional, Dhudha, Herry, additional, Mumia, Mediatrix, additional, Baker, Francine G, additional, Okusolubo, Temi, additional, Ayers, Leona W, additional, Bhatia, Kishor, additional, Goedert, James J, additional, Woo, Joshua G, additional, Cole, Nathan, additional, Luo, Wen, additional, Hicks, Belynda, additional, Adeyemo, Adebowale A, additional, Prokunina-Olsson, Ludmila, additional, Shriner, Daniel N., additional, Rotimi, Charles N, additional, Chagaluka, George, additional, Johnston, W Thomas, additional, Mutalima, Nora, additional, Borgstein, Eric, additional, Liomba, George N, additional, Kamiza, Steve, additional, Mkandawire, Nyengo, additional, Mitambo, Collins, additional, Molyneux, Elizabeth, additional, Newton, Robert, additional, Manning, Michelle, additional, Fraumeni, Joseph F, additional, Pfeiffer, Ruth M, additional, Hutchinson, Amy, additional, Yeager, Meredith, additional, Thein, Swee Lay, additional, Chanock, Stephen J., additional, and Mbulaiteye, Sam M., additional

Published
2022
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23. HBB rs334, ABO Rs8176703 and Plasmodium Falciparum Positivity at Enrollment Are Independently Associated with Lower Risk for Endemic Burkitt Lymphoma in Uganda, Tanzania, Kenya, and Malawi

Author

Hong, Hyokyoung G, Gouveia, Mateus H, Ogwang, Martin, Kerchan, Patrick, Reynolds, Steven, Tenge, Constance N, Were, Pamela A, Kuremu, Robert T, Wekesa, Walter N, Masalu, Nestory, Kawira, Esther, Kinyera, Tobias, Wang, Xunde, Zhou, Jiefu, Otim, Isaac, Legason, Ismail D, Nabalende, Hadijah, Dhudha, Herry, Mumia, Mediatrix, Baker, Francine G, Okusolubo, Temi, Ayers, Leona W, Bhatia, Kishor, Goedert, James J, Woo, Joshua G, Cole, Nathan, Luo, Wen, Hicks, Belynda, Adeyemo, Adebowale A, Prokunina-Olsson, Ludmila, Shriner, Daniel N., Rotimi, Charles N, Chagaluka, George, Johnston, W Thomas, Mutalima, Nora, Borgstein, Eric, Liomba, George N, Kamiza, Steve, Mkandawire, Nyengo, Mitambo, Collins, Molyneux, Elizabeth, Newton, Robert, Manning, Michelle, Fraumeni, Joseph F, Jr., Pfeiffer, Ruth M, Hutchinson, Amy, Yeager, Meredith, Thein, Swee Lay, Chanock, Stephen J., and Mbulaiteye, Sam M.

Published
2022
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25. Epstein-Barr Virus in Burkitt Lymphoma in Africa Reveals a Limited Set of Whole Genome and LMP-1 Sequence Patterns: Analysis of Archival Datasets and Field Samples From Uganda, Tanzania, and Kenya

Author

Liao, Hsiao-Mei, primary, Liu, Hebing, additional, Chin, Pei-Ju, additional, Li, Bingjie, additional, Hung, Guo-Chiuan, additional, Tsai, Shien, additional, Otim, Isaac, additional, Legason, Ismail D., additional, Ogwang, Martin D., additional, Reynolds, Steven J., additional, Kerchan, Patrick, additional, Tenge, Constance N., additional, Were, Pamela A., additional, Kuremu, Robert T., additional, Wekesa, Walter N., additional, Masalu, Nestory, additional, Kawira, Esther, additional, Ayers, Leona W., additional, Pfeiffer, Ruth M., additional, Bhatia, Kishor, additional, Goedert, James J., additional, Lo, Shyh-Ching, additional, and Mbulaiteye, Sam M., additional

Published
2022
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30. Additional file 1 of Inverse association of falciparum positivity with endemic Burkitt lymphoma is robust in analyses adjusting for pre-enrollment malaria in the EMBLEM case-control study

Author

Peprah, Sally, Ogwang, Martin D., Kerchan, Patrick, Reynolds, Steven J., Tenge, Constance N., Were, Pamela A., Kuremu, Robert T., Wekesa, Walter N., Masalu, Nestory, Kawira, Esther, Otim, Isaac, Legason, Ismail D., Ayers, Leona W., Bhatia, Kishor, Goedert, James J., Pfeiffer, Ruth M., and Mbulaiteye, Sam M.

Abstract

Additional file 1: Supplementary Table 1. Questionnaire variables/data elements and how they were coded for exploratory factor analysis. Supplementary Table 2. Eigenvalue and variance explained by extracted factors shown for each imputed dataset and by study country. Supplementary Table 3. Odds ratios and 95% confidence intervals (CIs) of the association of factors with falciparum infection risk in controls, by country. Supplementary Table 4. Odds ratios and 95% confidence intervals (CIs) of the association of factors with eBL risk, by country.

Published
2021
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36. AIDS-related vasculopathy: evidence for oxidative and inflammatory pathways in murine and human AIDS

Author

Baliga, Reshma S., Chaves, Alysia A., Jing, Liang, Ayers, Leona W., and Bauer, John A.

Subjects
HIV (Viruses) -- Research, HIV (Viruses) -- Health aspects, Life expectancy -- Research, Heart -- Research, Biological sciences
Abstract

Increased life expectancy of human immunodeficiency virus (HIV)-positive patients has led to evidence of complications apparently not directly related to immunodeficiency or opportunistic infection, including increased cardiovascular risk. We tested the hypothesis that vascular dysfunction occurs in the routine acquired immune deficiency syndrome (AIDS) model and evaluated potential mechanisms in routine AIDS tissues and relevant human HIV/AIDS vascular tissues. We also investigated endothelial activation and/or endothelial protein nitration and their association with time-dependent vascular dysfunction. At 1 and 5 wk of routine AIDS, statistically significant decreases in KCl contractility and time-dependent contractile deficits in response to phenylephrine were observed. The maximal response ([E.sub.max]) was reduced by ~40% at 10 wk, and E[C.sub.50] values were significantly changed: 102 [+ or -] 7.3 ng for control vs. 190 [+ or -] 37 and 130 [+ or -] 22 ng at 5 and 10 wk, respectively (P < 0.05). Endothelium-dependent relaxation to ACh was decreased (E[C.sub.50] = 120 [+ or -] 27 and 343 [+ or -] 94 nM for control and at 10 wk, respectively), whereas the response to an exogenous nitric oxide donor, sodium nitroprusside, remained unchanged, suggesting a specific endothelial dysfunction. Histochemical investigations of the same vascular tissues as well as corresponding coronary endothelium showed an increase in protein 3-nitrotyrosine, intercellular adhesion molecule, and nitric oxide synthase isoforms 2 and 3. These findings were corroborated in concurrent experiments in a cohort of well-cataloged human cardiac microvascular tissues. We have demonstrated, for the first time, a specific functional vasculopathy with endothelial involvement in a murine model of AIDS that was also associated with and correlated to increased oxidative stress and specific endothelial activation. This finding was echoed in a relevant population of human HIV/AIDS patients. Research into sources and intracellular targets of oxidants in this disease could provide important mechanistic insights and may reveal new therapeutic opportunities for this increasingly important cardiovascular disease state. endothelial function; inflammation; oxidants

Published
2005

42. Endemic Burkitt Lymphoma in second-degree relatives in Northern Uganda: in-depth genome-wide analysis suggests clues about genetic susceptibility

Author

Gouveia, Mateus H., primary, Otim, Isaac, additional, Ogwang, Martin D., additional, Wang, Mingyi, additional, Zhu, Bin, additional, Cole, Nathan, additional, Luo, Wen, additional, Hicks, Belynda, additional, Jones, Kristine, additional, Oehl-Huber, Kathrin, additional, Ayers, Leona W., additional, Pittaluga, Stefania, additional, Legason, Ismail D., additional, Nabalende, Hadijah, additional, Kerchan, Patrick, additional, Kinyera, Tobias, additional, Kawira, Esther, additional, Brubaker, Glen, additional, Levin, Arthur G., additional, Guertler, Lutz, additional, Kim, Jung, additional, Stewart, Douglas R., additional, Adde, Melissa, additional, Magrath, Ian, additional, Bergen, Andrew W., additional, Reynolds, Steven J., additional, Yeager, Meredith, additional, Bhatia, Kishor, additional, Adeyemo, Adebowale A., additional, Prokunina-Olsson, Ludmila, additional, Dean, Michael, additional, Shriner, Daniel, additional, Rotimi, Charles N., additional, Chanock, Stephen, additional, Siebert, Reiner, additional, and Mbulaiteye, Sam M., additional

Published
2020
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43. Mean platelet counts are relatively decreased with malaria but relatively increased with endemic Burkitt Lymphoma in Uganda, Tanzania, and Kenya

Author

Peprah, Sally, primary, Ogwang, Martin D., additional, Kerchan, Patrick, additional, Reynolds, Steven J., additional, Tenge, Constance N., additional, Were, Pamela A., additional, Kuremu, Robert T., additional, Wekesa, Walter N, additional, Masalu, Nestory, additional, Kawira, Esther, additional, Kinyera, Tobias, additional, Otim, Isaac, additional, Legason, Ismail D., additional, Nabalende, Hadijah, additional, Dhudha, Herry, additional, Mumia, Mediatrix, additional, Ayers, Leona W., additional, Biggar, Robert J., additional, Bhatia, Kishor, additional, Goedert, James J., additional, and Mbulaiteye, Sam M., additional

Published
2020
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44. Variation in the Human Leukocyte Antigen system and risk for endemic Burkitt lymphoma in northern Uganda

Author

Kirimunda, Samuel, primary, Verboom, Murielle, additional, Otim, Isaac, additional, Ssennono, Mark, additional, Legason, Ismail D., additional, Nabalende, Hadijah, additional, Ogwang, Martin D., additional, Kerchan, Patrick, additional, Kinyera, Tobias, additional, Mwebaza, Ivan, additional, Joloba, Moses, additional, Ayers, Leona W., additional, Reynolds, Steven J., additional, Bhatia, Kishor, additional, Onabajo, Olusegun O., additional, Hallensleben, Michael, additional, Biggar, Robert J., additional, Prokunina‐Olsson, Ludmila, additional, Goedert, James J., additional, Blasczyk, Rainer, additional, and Mbulaiteye, Sam M., additional

Published
2020
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48. Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studies

Author

Derkach, Andriy, Otim, Isaac, Pfeiffer, Ruth M., Onabajo, Olusegun O., Legason, Ismail D., Nabalende, Hadijah, Ogwang, Martin D., Kerchan, Patrick, Talisuna, Ambrose O., Ayers, Leona W., Reynolds, Steven J., Nkrumah, Francis, Neequaye, Janet, Bhatia, Kishor, Theander, Thor G., Prokunina-Olsson, Ludmila, Turner, Louise, Goedert, James J., Lavstsen, Thomas, Mbulaiteye, Sam M., Derkach, Andriy, Otim, Isaac, Pfeiffer, Ruth M., Onabajo, Olusegun O., Legason, Ismail D., Nabalende, Hadijah, Ogwang, Martin D., Kerchan, Patrick, Talisuna, Ambrose O., Ayers, Leona W., Reynolds, Steven J., Nkrumah, Francis, Neequaye, Janet, Bhatia, Kishor, Theander, Thor G., Prokunina-Olsson, Ludmila, Turner, Louise, Goedert, James J., Lavstsen, Thomas, and Mbulaiteye, Sam M.

Abstract

Background: Endemic Burkitt lymphoma (eBL) is an aggressive childhood B-cell lymphoma linked to Plasmodium falciparum (Pf) malaria in sub-Saharan Africa. We investigated antibody reactivity to several human receptor-binding domains of the Pf erythrocyte membrane protein 1 (PfEMP1) that play a key role in malaria pathogenesis and are targets of acquired immunity to malaria. Methods: Serum/plasma IgG antibody reactivity was measured to 22 Pf antigens, including 18 to PfEMP1 CIDR domains between cases and controls from two populations (149 eBL cases and 150 controls from Ghana and 194 eBL cases and 600 controls from Uganda). Adjusted odds ratios (aORs) for case-control associations were estimated by logistic regression. Findings: There was stronger reactivity to the severe malaria associated CIDRα1 domains than other CIDR domains both in cases and controls. eBL cases reacted to fewer antigens than controls (Ghana: p = 0·001; Uganda: p = 0·03), with statistically significant lower ORs associated with reactivity to 13+ antigens in Ghana (aOR 0·39, 95% CI 0·24–0·63; pheterogeneity = 0·00011) and Uganda (aOR 0·60, 95% CI 0.41–0·88; pheterogeneity = 0·008). eBL was inversely associated with reactivity, coded as quartiles, to group A variant CIDRδ1 (ptrend = 0·035) in Ghana and group B CD36-binding variants CIDRα2·2 (ptrend = 0·006) and CIDRα2·4 (ptrend = 0·033) in Uganda, and positively associated with reactivity to SERA5 in Ghana (ptrend = 0·017) and Uganda (ptrend = 0·007) and group A CIDRα1·5 variant in Uganda only (ptrend = 0·034). Interpretation: eBL cases reacted to fewer antigens than controls using samples from two populations, Ghana and Uganda. Attenuated humoral immunity to Pf EMP1 may contribute to susceptibility to low-grade malaria and eBL risk. Funding: Intramural Research Program, National Cancer Institute and National Institute of Allergy and Infectious Diseases, Natio

Published
2019

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