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3. OA23 Time to address the challenge of difficult-to-treat psoriatic arthritis: results from an international survey

Author

Marzo-Ortega, Helena, primary, Harrison, Stephanie R, additional, Nagy, György, additional, Machado, Pedro M, additional, McGonagle, Dennis G, additional, Aydin, Sibel Z, additional, Almodovar, Raquel, additional, Bautista-Molano, Wilson, additional, Gossec, Laure, additional, Lobrano, Ennio, additional, Nash, Peter, additional, Pimentel dos Santos, Fernando, additional, Soriano, Enrique, additional, and Siebert, Stefan, additional

Published
2024
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5. Sex differences in the efficacy, safety and persistence of patients with psoriatic arthritis treated with tofacitinib: a post-hoc analysis of phase 3 trials and long-term extension

Author

Eder, Lihi, primary, Gladman, Dafna D, additional, Mease, Philip, additional, Pollock, Remy A, additional, Luna, Rayana, additional, Aydin, Sibel Z, additional, Ogdie, Alexis, additional, Polachek, Ari, additional, Gruben, David, additional, Cadatal, Mary Jane, additional, Kinch, Cassandra, additional, and Strand, Vibeke, additional

Published
2023
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9. Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study

Author

Renauer, Paul A., Saruhan-Direskeneli, Guher, Coit, Patrick, Adler, Adam, Aksu, Kenan, Keser, Gokhan, Alibaz-Oner, Fatma, Aydin, Sibel Z., Kamali, Sevil, Inanc, Murat, Carette, Simon, Cuthbertson, David, Hoffman, Gary S., Akar, Servet, Onen, Fatos, Akkoc, Nurullah, Khalidi, Nader A., Koening, Curry, Karadag, Omer, Kiraz, Sedat, Langford, Carol A., Maksimowicz-McKinnon, Kathleen, McAlear, Carol A., Ozbalkan, Zeynep, Ates, Askin, Karaaslan, Yasar, Duzgun, Nursen, Monach, Paul A., Ozer, Huseyin T. E., Erken, Eren, Ozturk, Mehmet A., Yazici, Ayten, Cefle, Ayse, Onat, Ahmet Mesut, Kisacik, Bunyamin, Pagnoux, Christian, Kasifoglu, Timucin, Seyahi, Emire, Fresko, Izzet, Seo, Philip, Sreih, Antoine G., Warrington, Kenneth J., Ytterberg, Steven R., Cobankara, Veli, Cunninghame-Graham, Deborah S., Vyse, Timothy J., Pamuk, Omer N., Tunc, Ercan S., Dalkilic, Ediz, Bicakcigil, Muge, Yentur, Sibel P., Wren, Jonathan D., Merkel, Peter A., Direskeneli, Haner, and Sawalha, Amr H.

Published
2015
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11. Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study

Author

Ortiz-Fernandez, Lourdes, Saruhan-Direskeneli, Guher, Alibaz-Oner, Fatma, Kaymaz-Tahra, Sema, Coit, Patrick, Kong, Xiufang, Kiprianos, Allan P., Maughan, Robert T., Aydin, Sibel Z., Aksu, Kenan, Keser, Gokhan, Kamali, Sevil, Inanc, Murat, Springer, Jason, Akar, Servet, Onen, Fatos, Akkoc, Nurullah, Khalidi, Nader A., Koening, Curry, Karadag, Omer, Kiraz, Sedat, Forbess, Lindsy, Langford, Carol A., McAlear, Carol A., Ozbalkan, Zeynep, Yavuz, Sule, Cetin, Gozde Yildirim, Alpay-Kanitez, Nilufer, Chung, Sharon, Ates, Askin, Karaaslan, Yasar, McKinnon-Maksimowicz, Kathleen, Monach, Paul A., Ozer, Huseyin T. E., Seyahi, Emire, Fresko, Izzet, Cefle, Ayse, Seo, Philip, Warrington, Kenneth J., Ozturk, Mehmet A., Ytterberg, Steven R., Cobankara, Veli, Onat, Ahmet Mesut, Duzgun, Nursen, Bicakcigil, Muge, Yentur, Sibel P., Lally, Lindsay, Manfredi, Angelo A., Baldissera, Elena, Erken, Eren, Yazici, Ayten, Kisacik, Bunyamin, Kasifoglu, Timucin, Dalkilic, Ediz, Cuthbertson, David, Pagnoux, Christian, Sreih, Antoine, Reales, Guillermo, Wallace, Chris, Wren, Jonathan D., Cunninghame-Graham, Deborah S., Vyse, Timothy J., Sun, Ying, Chen, Huiyong, Grayson, Peter C., Tombetti, Enrico, Jiang, Lindi, Mason, Justin C., Merkel, Peter A., Direskeneli, Haner, Sawalha, Amr H., Ortiz-Fernandez, Lourdes, Saruhan-Direskeneli, Guher, Alibaz-Oner, Fatma, Kaymaz-Tahra, Sema, Coit, Patrick, Kong, Xiufang, Kiprianos, Allan P., Maughan, Robert T., Aydin, Sibel Z., Aksu, Kenan, Keser, Gokhan, Kamali, Sevil, Inanc, Murat, Springer, Jason, Akar, Servet, Onen, Fatos, Akkoc, Nurullah, Khalidi, Nader A., Koening, Curry, Karadag, Omer, Kiraz, Sedat, Forbess, Lindsy, Langford, Carol A., McAlear, Carol A., Ozbalkan, Zeynep, Yavuz, Sule, Cetin, Gozde Yildirim, Alpay-Kanitez, Nilufer, Chung, Sharon, Ates, Askin, Karaaslan, Yasar, McKinnon-Maksimowicz, Kathleen, Monach, Paul A., Ozer, Huseyin T. E., Seyahi, Emire, Fresko, Izzet, Cefle, Ayse, Seo, Philip, Warrington, Kenneth J., Ozturk, Mehmet A., Ytterberg, Steven R., Cobankara, Veli, Onat, Ahmet Mesut, Duzgun, Nursen, Bicakcigil, Muge, Yentur, Sibel P., Lally, Lindsay, Manfredi, Angelo A., Baldissera, Elena, Erken, Eren, Yazici, Ayten, Kisacik, Bunyamin, Kasifoglu, Timucin, Dalkilic, Ediz, Cuthbertson, David, Pagnoux, Christian, Sreih, Antoine, Reales, Guillermo, Wallace, Chris, Wren, Jonathan D., Cunninghame-Graham, Deborah S., Vyse, Timothy J., Sun, Ying, Chen, Huiyong, Grayson, Peter C., Tombetti, Enrico, Jiang, Lindi, Mason, Justin C., Merkel, Peter A., Direskeneli, Haner, and Sawalha, Amr H.

Abstract

Takayasu arteritis is a rare inflammatory disease of large arteries. We performed a genetic study in Takayasu arteritis comprising 6,670 individuals (1,226 affected individuals) from five different populations. We discovered HLA risk factors and four non-HLA susceptibility loci in VPS8, SVEP1, CFL2, and chr13q21 and reinforced IL12B, PTK2B, and chr21q22 as robust susceptibility loci shared across ancestries. Functional analysis proposed plausible underlying disease mechanisms and pinpointed ETS2 as a potential causal gene for chr21q22 association. We also identified >60 candidate loci with suggestive association (p < 5 x 10(-s)) and devised a genetic risk score for Takayasu arteritis. Takayasu arteritis was compared to hundreds of other traits, revealing the closest genetic relatedness to inflammatory bowel disease. Epigenetic patterns within risk loci suggest roles for monocytes and B cells in Takayasu arteritis. This work enhances understanding of the genetic basis and pathophysiology of Takayasu arteritis and provides clues for potential new therapeutic targets.

Published
2021
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15. Identification of susceptibility loci for Takayasu arteritis through a large multi-ancestral genome-wide association study

Author

Ortiz-Fernández, Lourdes, primary, Saruhan-Direskeneli, Güher, additional, Alibaz-Oner, Fatma, additional, Kaymaz-Tahra, Sema, additional, Coit, Patrick, additional, Kong, Xiufang, additional, Kiprianos, Allan P., additional, Maughan, Robert T., additional, Aydin, Sibel Z., additional, Aksu, Kenan, additional, Keser, Gokhan, additional, Kamali, Sevil, additional, Inanc, Murat, additional, Springer, Jason, additional, Akar, Servet, additional, Onen, Fatos, additional, Akkoc, Nurullah, additional, Khalidi, Nader A., additional, Koening, Curry, additional, Karadag, Omer, additional, Kiraz, Sedat, additional, Forbess, Lindsy, additional, Langford, Carol A., additional, McAlear, Carol A., additional, Ozbalkan, Zeynep, additional, Yavuz, Sule, additional, Çetin, Gozde Yildirim, additional, Alpay-Kanitez, Nilufer, additional, Chung, Sharon, additional, Ates, Askin, additional, Karaaslan, Yasar, additional, McKinnon-Maksimowicz, Kathleen, additional, Monach, Paul A., additional, Ozer, Hüseyin T.E., additional, Seyahi, Emire, additional, Fresko, Izzet, additional, Cefle, Ayse, additional, Seo, Philip, additional, Warrington, Kenneth J., additional, Ozturk, Mehmet A., additional, Ytterberg, Steven R., additional, Cobankara, Veli, additional, Onat, Ahmet Mesut, additional, Duzgun, Nurşen, additional, Bıcakcıgil, Muge, additional, Yentür, Sibel P., additional, Lally, Lindsay, additional, Manfredi, Angelo A., additional, Baldissera, Elena, additional, Erken, Eren, additional, Yazici, Ayten, additional, Kısacık, Bünyamin, additional, Kaşifoğlu, Timuçin, additional, Dalkilic, Ediz, additional, Cuthbertson, David, additional, Pagnoux, Christian, additional, Sreih, Antoine, additional, Reales, Guillermo, additional, Wallace, Chris, additional, Wren, Jonathan D., additional, Cunninghame-Graham, Deborah S., additional, Vyse, Timothy J., additional, Sun, Ying, additional, Chen, Huiyong, additional, Grayson, Peter C., additional, Tombetti, Enrico, additional, Jiang, Lindi, additional, Mason, Justin C., additional, Merkel, Peter A., additional, Direskeneli, Haner, additional, and Sawalha, Amr H., additional

Published
2021
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24. Impact of Having Family History of Psoriasis or Psoriatic Arthritis on Psoriatic Disease

Author

Solmaz, Dilek, primary, Bakirci, Sibel, additional, Kimyon, Gezmis, additional, Gunal, Esen K., additional, Dogru, Atalay, additional, Bayindir, Ozun, additional, Dalkilic, Ediz, additional, Ozisler, Cem, additional, Can, Meryem, additional, Akar, Servet, additional, Cetin, Gozde Y., additional, Yavuz, Sule, additional, Kilic, Levent, additional, Tarhan, Emine F., additional, Kucuksahin, Orhan, additional, Omma, Ahmet, additional, Gonullu, Emel, additional, Yildiz, Fatih, additional, Ersozlu, Emine D., additional, Cinar, Muhammet, additional, Al‐Onazi, Atallah, additional, Erden, Abdulsamet, additional, Tufan, Muge A., additional, Yilmaz, Sema, additional, Pehlevan, Seval, additional, Kalyoncu, Umut, additional, and Aydin, Sibel Z., additional

Published
2019
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25. Corrigendum: Analysis of the common genetic component of large-vessel vasculitides through a meta-Immunochip strategy (Scientific Reports (2017) 7 (43953) DOI: 10.1038/srep43953)

Author

Martínez Berriochoa, Agustín, Unzurrunzaga, Ainhoa, Hidalgo Conde, Ana, Vuelta, Ana Belén Madroñero, Fernández Nebro, Antonio, Carmen Ordóñez Cañizares, M., Fernández Gutiérrez, Benjamín, Rodríguez Rodríguez, Luis, Escalante, Begoña, Alfonso, Begoña Marí, Sopeña, Bernardo, Gómez Vaquero, Carmen, Raya, Enrique, Grau, Elena, Román, José A., Vicente, Esther F., Miguel, Eugenio de, López Longo, Francisco J., Martínez, Lina, Morado, Inmaculada C., Bernardino Díaz López, J., Caminal Montero, Luis, Martínez Zapico, Aleida, Narváez, Javier, Monfort, Jordi, Tío, Laura, Filloy, José A. Miranda, Sánchez Martín, Julio, Alegre Sancho, Juan J., Sáez Comet, Luis, Conesa, Mercedes Pérez, Corbera Bellalta, Marc, Ramentol Sintas, Marc, García Villanueva, María Jesús, Rojas, Mercedes Guijarro, Ortego Centeno, Norberto, Fernández, Raquel Ríos, Callejas, José Luis, Pernaute, Olga Sanchez, Mateo, Patricia Fanlo, Blanco, Ricardo, González, Sergio Prieto, Soriano, Víctor Manuel Martínez T.a.b.o.a.d.a.1.1. Alessandra, Lunardi, Claudio, Gianfreda, Davide, Santilli, Daniele, Bonatti, Francesco, Muratore, Francesco, Pazzola, Giulia, ADDIMANDA, OLGA, Emmi, Giacomo, Ramirez, Giuseppe A., Beretta, Lorenzo, Govoni, Marcello, Onat, Marco A. C.i.m.m.i.n.o.5.2. Ahmet Mesut, Cefle, Ayse, Yazici, Ayten, Kısacık, Bünyamin, Dalkilic, Ediz, Seyahi, Emire, Fresko, Izzet, Tunc, Ercan, Erken, Eren, Ozer, Hüseyin TE, Aksu, Kenan, Keser, Gokhan, Ozturk, Mehmet A., Bıcakcıgil, Muge, Duzgun, Nurşen, Karadag, Omer, Kiraz, Sedat, Pamuk, Ömer N., Akar, Servet, Onen, Fatos, Akkoc, Nurullah, Kamali, Sevil, Inanc, Murat, Yentür, Sibel P., Aydin, Sibel Z., Alibaz Oner, Fatma, Kaşifoğlu, Timuçin, Cobankara, Veli, Ozbalkan, Zeynep, Ates, Askin, Carette, Yasar K.a.r.a.a.s.l.a.n.7.3. Simon, Chung, Sharon A., Cuthbertson, David, Forbess, Lindsay J., Hoffman, Gary S., Khalidi, Nader A., Koening, Curry L., Langford, Carol A., Mcalear, Carol A., McKinnon Maksimowicz, Kathleen, Monach, Paul A., Moreland, Larry, Pagnoux, Christian, Seo, Philip, Spiera, Robert, Sreih, Antoine G., Warrington, Kenneth J., Ytterberg87, Steven R. ., Martínez-Berriochoa, Agustín, Unzurrunzaga, Ainhoa, Hidalgo-Conde, Ana, Vuelta, Ana Belén Madroñero, Fernández-Nebro, Antonio, Carmen Ordóñez-Cañizares, M., Fernández-Gutiérrez, Benjamín, Rodríguez-Rodríguez, Lui, Escalante, Begoña, Alfonso, Begoña Marí, Sopeña, Bernardo, Gómez-Vaquero, Carmen, Raya, Enrique, Grau, Elena, Román, José A., Vicente, Esther F., Miguel, Eugenio de, López-Longo, Francisco J., Martínez, Lina, Morado, Inmaculada C., Bernardino Díaz-López, J., Caminal-Montero, Lui, Martínez-Zapico, Aleida, Narváez, Javier, Monfort, Jordi, Tío, Laura, Filloy, José A. Miranda, Sánchez-Martín, Julio, Alegre-Sancho, Juan J., Sáez-Comet, Lui, Conesa, Mercedes Pérez, Corbera-Bellalta, Marc, Ramentol-Sintas, Marc, García-Villanueva, María Jesú, Rojas, Mercedes Guijarro, Ortego-Centeno, Norberto, Fernández, Raquel Río, Callejas, José Lui, Pernaute, Olga Sanchez, Mateo, Patricia Fanlo, Blanco, Ricardo, González, Sergio Prieto, Soriano, Víctor Manuel Martínez-Taboada11.Alessandra, Lunardi, Claudio, Gianfreda, Davide, Santilli, Daniele, Bonatti, Francesco, Muratore, Francesco, Pazzola, Giulia, Addimanda, Olga, Emmi, Giacomo, Ramirez, Giuseppe A., Beretta, Lorenzo, Govoni, Marcello, Onat, Marco A. Cimmino52. Ahmet Mesut, Cefle, Ayse, Yazici, Ayten, Kısacık, Bünyamin, Dalkilic, Ediz, Seyahi, Emire, Fresko, Izzet, Tunc, Ercan, Erken, Eren, Ozer, Hüseyin TE, Aksu, Kenan, Keser, Gokhan, Ozturk, Mehmet A., Bıcakcıgil, Muge, Duzgun, Nurşen, Karadag, Omer, Kiraz, Sedat, Pamuk, Ömer N., Akar, Servet, Onen, Fato, Akkoc, Nurullah, Kamali, Sevil, Inanc, Murat, Yentür, Sibel P., Aydin, Sibel Z., Alibaz-Oner, Fatma, Kaşifoğlu, Timuçin, Cobankara, Veli, Ozbalkan, Zeynep, Ates, Askin, Carette, Yasar Karaaslan73. Simon, Chung, Sharon A., Cuthbertson, David, Forbess, Lindsay J., Hoffman, Gary S., Khalidi, Nader A., Koening, Curry L., Langford, Carol A., Mcalear, Carol A., McKinnon-Maksimowicz, Kathleen, Monach, Paul A., Moreland, Larry, Pagnoux, Christian, Seo, Philip, Spiera, Robert, Sreih, Antoine G., Warrington, Kenneth J., and Ytterberg87, Steven R. .

Subjects
Multidisciplinary, skin and connective tissue diseases
Abstract

Giant cell arteritis (GCA) and Takayasu’s arteritis (TAK) are major forms of large-vessel vasculitis (LVV) that share clinical features. To evaluate their genetic similarities, we analysed Immunochip genotyping data from 1,434 LVV patients and 3,814 unaffected controls. Genetic pleiotropy was also estimated. The HLA region harboured the main disease-specific associations. GCA was mostly associated with class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostly associated with class I genes (HLA-B/ MICA). Both the statistical significance and effect size of the HLA signals were considerably reduced in the cross-disease meta-analysis in comparison with the analysis of GCA and TAK separately. Consequently, no significant genetic correlation between these two diseases was observed when HLA variants were tested. Outside the HLA region, only one polymorphism located nearby the IL12B gene surpassed the study-wide significance threshold in the meta-analysis of the discovery datasets (rs755374, P = 7.54E-07; ORGCA = 1.19, ORTAK = 1.50). This marker was confirmed as novel GCA risk factor using four additional cohorts (PGCA = 5.52E-04, ORGCA = 1.16). Taken together, our results provide evidence of strong genetic differences between GCA and TAK in the HLA. Outside this region, common susceptibility factors were suggested, especially within the IL12B locus.

Published
2017

26. Analysis of the common genetic component of large-vessel vasculitides through a meta-Immunochip strategy

Author

Martínez Berriochoa, Agustín, Unzurrunzaga, Ainhoa, Hidalgo Conde, Ana, Vuelta, Ana Belén Madroñero, Fernández Nebro, Antonio, Carmen Ordóñez Cañizares, M., Fernández Gutiérrez, Benjamín, Rodríguez Rodríguez, Luis, Escalante, Begoña, Alfonso, Begoña Marí, Sopeña, Bernardo, Gómez Vaquero, Carmen, Raya, Enrique, Grau, Elena, Román, José A., Vicente, Esther F., Miguel, Eugenio de, López Longo, Francisco J., Martínez, Lina, Morado, Inmaculada C., Bernardino Díaz López, J., Caminal Montero, Luis, Martínez Zapico, Aleida, Narváez, Javier, Monfort, Jordi, Tío, Laura, Filloy, José A. Miranda, Sánchez Martín, Julio, Alegre Sancho, Juan J., Sáez Comet, Luis, Conesa, Mercedes Pérez, Corbera Bellalta, Marc, Ramentol Sintas, Marc, García Villanueva, María Jesús, Rojas, Mercedes Guijarro, Ortego Centeno, Norberto, Fernández, Raquel Ríos, Callejas, José Luis, Pernaute, Olga Sanchez, Mateo, Patricia Fanlo, Blanco, Ricardo, González, Sergio Prieto, Soriano, Víctor Manuel Martínez T.a.b.o.a.d.a.1.1. Alessandra, Lunardi, Claudio, Gianfreda, Davide, Santilli, Daniele, Bonatti, Francesco, Muratore, Francesco, Pazzola, Giulia, ADDIMANDA, OLGA, Emmi, Giacomo, Ramirez, Giuseppe A., Beretta, Lorenzo, Govoni, Marcello, Onat, Marco A. Cimmino52 Ahmet Mesut, Cefle, Ayse, Yazici, Ayten, Kısacık, Bünyamin, Dalkilic, Ediz, Seyahi, Emire, Fresko, Izzet, Tunc, Ercan, Erken, Eren, Ozer, Hüseyin TE, Aksu, Kenan, Keser, Gokhan, Ozturk, Mehmet A., Bıcakcıgil, Muge, Duzgun, Nurşen, Karadag, Omer, Kiraz, Sedat, Pamuk, Ömer N., Akar, Servet, Onen, Fatos, Akkoc, Nurullah, Kamali, Sevil, Inanc, Murat, Yentür, Sibel P., Aydin, Sibel Z., Alibaz Oner, Fatma, Kaşifoğlu, Timuçin, Cobankara, Veli, Ozbalkan, Zeynep, Ates, Askin, Carette, Yasar Karaaslan73 Simon, Chung, Sharon A., Cuthbertson, David, Forbess, Lindsay J., Hoffman, Gary S., Khalidi, Nader A., Koening, Curry L., Langford, Carol A., Mcalear, Carol A., McKinnon Maksimowicz, Kathleen, Monach, Paul A., Moreland, Larry, Pagnoux, Christian, Seo, Philip, Spiera, Robert, Sreih, Antoine G., Warrington, Kenneth J., Ytterberg87, Steven R. ., Universidad de Cantabria, David Carmona, F., Coit, Patrick, Saruhan-Direskeneli, Guher, Hernandez-Rodriguez, Jose, Cid, Maria C., Solans, Roser, Castaneda, Santos, Vaglio, Augusto, Direskeneli, Haner, Merkel, Peter A., Boiardi, Luigi, Salvarani, Carlo, Gonzalez-Gay, Miguel A., Martin, Javier, Sawalha, Amr H., Institut Català de la Salut, [Carmona FD] Instituto de Parasitología y Biomedicina ‘López-Neyra’, IPBLN-CSIC, PTS Granada, Granada, Spain. Departamento de Genética e Instituto de Biotecnología, Universidad de Granada, Granada 18016, Spain. [Coit P] Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA. [Saruhan-Direskeneli G] Department of Physiology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey. [Hernández-Rodríguez J, Cid MC] Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic, University of Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. [Solans R] Unitat de Malalties Autoimmunes Sistèmiques, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus, Martínez-Berriochoa, Agustín, Unzurrunzaga, Ainhoa, Hidalgo-Conde, Ana, Vuelta, Ana Belén Madroñero, Fernández-Nebro, Antonio, Carmen Ordóñez-Cañizares, M., Fernández-Gutiérrez, Benjamín, Rodríguez-Rodríguez, Lui, Escalante, Begoña, Alfonso, Begoña Marí, Sopeña, Bernardo, Gómez-Vaquero, Carmen, Raya, Enrique, Grau, Elena, Román, José A., Vicente, Esther F., Miguel, Eugenio de, López-Longo, Francisco J., Martínez, Lina, Morado, Inmaculada C., Bernardino Díaz-López, J., Caminal-Montero, Lui, Martínez-Zapico, Aleida, Narváez, Javier, Monfort, Jordi, Tío, Laura, Filloy, José A. Miranda, Sánchez-Martín, Julio, Alegre-Sancho, Juan J., Sáez-Comet, Lui, Conesa, Mercedes Pérez, Corbera-Bellalta, Marc, Ramentol-Sintas, Marc, García-Villanueva, María Jesú, Rojas, Mercedes Guijarro, Ortego-Centeno, Norberto, Fernández, Raquel Río, Callejas, José Lui, Pernaute, Olga Sanchez, Mateo, Patricia Fanlo, Blanco, Ricardo, González, Sergio Prieto, Soriano, Víctor Manuel Martínez-Taboada11.Alessandra, Lunardi, Claudio, Gianfreda, Davide, Santilli, Daniele, Bonatti, Francesco, Muratore, Francesco, Pazzola, Giulia, Addimanda, Olga, Emmi, Giacomo, Ramirez, Giuseppe A., Beretta, Lorenzo, Govoni, Marcello, Onat, Marco A. Cimmino52 Ahmet Mesut, Cefle, Ayse, Yazici, Ayten, Kısacık, Bünyamin, Dalkilic, Ediz, Seyahi, Emire, Fresko, Izzet, Tunc, Ercan, Erken, Eren, Ozer, Hüseyin TE, Aksu, Kenan, Keser, Gokhan, Ozturk, Mehmet A., Bıcakcıgil, Muge, Duzgun, Nurşen, Karadag, Omer, Kiraz, Sedat, Pamuk, Ömer N., Akar, Servet, Onen, Fato, Akkoc, Nurullah, Kamali, Sevil, Inanc, Murat, Yentür, Sibel P., Aydin, Sibel Z., Alibaz-Oner, Fatma, Kaşifoğlu, Timuçin, Cobankara, Veli, Ozbalkan, Zeynep, Ates, Askin, Carette, Yasar Karaaslan73 Simon, Chung, Sharon A., Cuthbertson, David, Forbess, Lindsay J., Hoffman, Gary S., Khalidi, Nader A., Koening, Curry L., Langford, Carol A., Mcalear, Carol A., McKinnon-Maksimowicz, Kathleen, Monach, Paul A., Moreland, Larry, Pagnoux, Christian, Seo, Philip, Spiera, Robert, Sreih, Antoine G., Warrington, Kenneth J., Ytterberg87, Steven R. ., and Universitat de Barcelona

Subjects
Male, 0301 basic medicine, PATHOGENESIS, enfermedades cardiovasculares::enfermedades vasculares::vasculitis [ENFERMEDADES], Genome-wide association study, Cardiovascular Diseases::Vascular Diseases::Vasculitis [DISEASES], 0302 clinical medicine, vasculitides, Immunochip strategy, HLA Antigens, RHEUMATOLOGY 1990 CRITERIA, Medicine, skin and connective tissue diseases, Genetics, RISK, Multidisciplinary, Nervous System Diseases::Autoimmune Diseases of the Nervous System::Vasculitis, Central Nervous System::Giant Cell Arteritis [DISEASES], TAKAYASU ARTERITIS, ASSOCIATION, Genomics, Corrigenda, predisposición, 3. Good health, enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::vasculitis del sistema nervioso central::arteritis de células gigantes [ENFERMEDADES], Female, meta-Immunochip strategy, Vasculitis, Genotype, SUSCEPTIBILITY LOCI, Giant Cell Arteritis, Locus (genetics), POLYMYALGIA-RHEUMATICA, Human leukocyte antigen, Genetic correlation, 03 medical and health sciences, GIANT-CELL ARTERITIS, Genetic Pleiotropy, Humans, Genetic Predisposition to Disease, cardiovascular diseases, Arteritis, Genotyping, Arteritis de cèl·lules gegants, 030203 arthritis & rheumatology, Polymorphism, Genetic, IDENTIFICATION, business.industry, medicine.disease, common genetic component, Takayasu Arteritis, Giant cell arteritis, Genòmica, 030104 developmental biology, business, INFLAMMATORY-BOWEL-DISEASE, arge-vessel vasculitides
Abstract

Giant cell arteritis (GCA) and Takayasu's arteritis (TAK) are major forms of large-vessel vasculitis (LVV) that share clinical features. To evaluate their genetic similarities, we analysed Immunochip genotyping data from 1,434 LVV patients and 3,814 unaffected controls. Genetic pleiotropy was also estimated. The HLA region harboured the main disease-specific associations. GCA was mostly associated with class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostly associated with class I genes (HLA-B/MICA). Both the statistical significance and effect size of the HLA signals were considerably reduced in the cross-disease meta-analysis in comparison with the analysis of GCA and TAK separately. Consequently, no significant genetic correlation between these two diseases was observed when HLA variants were tested. Outside the HLA region, only one polymorphism located nearby the IL12B gene surpassed the study-wide significance threshold in the meta-analysis of the discovery datasets (rs755374, P = 7.54E-07; ORGCA = 1.19, ORTAK = 1.50). This marker was confirmed as novel GCA risk factor using four additional cohorts (PGCA = 5.52E-04, ORGCA = 1.16). Taken together, our results provide evidence of strong genetic differences between GCA and TAK in the HLA. Outside this region, common susceptibility factors were suggested, especially within the IL12B locus., This work was supported by SAF2012– 34435 from the Spanish Ministry of Economy and Competitiveness, BIO-1395 from Junta de Andalucía, and RD12/0009/0004 from the RETICS Program (RIER) of Instituto de Salud Carlos III (ISCIII). FDC was recipient of a grant from the ‘Ramón y Cajal’ programme of the Spanish Ministry of Economy and Competitiveness (RYC-2014–16458). MCC and JHR are supported by Ministerio de Economía y Competitividad (SAF 14/57708R), cofunded by “Fondo Europeo de Desarrollo Regional, Unión Europea, Una manera de hacer Europa” [Instituto de Salud Carlos III and Fondo Europeo de desarrollo regional (FEDER) (PIE 13/00033)]. The Vasculitis Clinical Research Consortium has received support from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54AR057319), the National Center for Research Resources (U54 RR019497), the Office of Rare Diseases Research, and the National Center for Advancing Translational Science. The VCRC is part of the Rare Diseases Clinical Research Network (RDCRN).

Published
2017

27. Supplementary_Material – Supplemental material for The Ottawa Panel guidelines on programmes involving therapeutic exercise for the management of hand osteoarthritis

Author

Brosseau, Lucie, Thevenot, Odette, MacKiddie, Olivia, Taki, Jade, Wells, George A, Guitard, Paulette, Léonard, Guillaume, Paquet, Nicole, Aydin, Sibel Z, Toupin-April, Karine, Cavallo, Sabrina, Moe, Rikke Helene, Shaikh, Kamran, Gifford, Wendy, Loew, Laurianne, Angelis, Gino De, Shallwani, Shirin Mehdi, Ala’ S Aburub, Imoto, Aline Mizusaki, Prinon Rahman, Gallardo, Inmaculada C Álvarez, Cosic, Milkana Borges, Østerås, Nina, Lue, Sabrina, Hamasaki, Tokiko, Gaudreault, Nathaly, Towheed, Tanveer E, Sahil Koppikar, Kjeken, Ingvild, Dharini Mahendira, Kenny, Glen P, Paterson, Gail, Westby, Marie, Laferrière, Lucie, and Longchamp, Guy

Subjects
FOS: Clinical medicine, 110604 Sports Medicine, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases, 110314 Orthopaedics
Abstract

Supplemental material, Supplementary_Material for The Ottawa Panel guidelines on programmes involving therapeutic exercise for the management of hand osteoarthritis by Lucie Brosseau, Odette Thevenot, Olivia MacKiddie, Jade Taki, George A Wells, Paulette Guitard, Guillaume Léonard, Nicole Paquet, Sibel Z Aydin, Karine Toupin-April, Sabrina Cavallo, Rikke Helene Moe, Kamran Shaikh, Wendy Gifford, Laurianne Loew, Gino De Angelis, Shirin Mehdi Shallwani, Ala’ S Aburub, Aline Mizusaki Imoto, Prinon Rahman, Inmaculada C Álvarez Gallardo, Milkana Borges Cosic, Nina Østerås, Sabrina Lue, Tokiko Hamasaki, Nathaly Gaudreault, Tanveer E Towheed, Sahil Koppikar, Ingvild Kjeken, Dharini Mahendira, Glen P Kenny, Gail Paterson, Marie Westby, Lucie Laferrière and Guy Longchamp in Clinical Rehabilitation

Published
2018
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28. Update on Outcome Measure Development in Large-vessel Vasculitis: Report from OMERACT 2018

Author

Aydin, Sibel Z., primary, Robson, Joanna C., additional, Sreih, Antoine G., additional, Hill, Catherine, additional, Alibaz-Oner, Fatma, additional, Mackie, Sarah, additional, Beard, Susan, additional, Gul, Ahmet, additional, Hatemi, Gülen, additional, Kermani, Tanaz A., additional, Mahr, Alfred, additional, Meara, Alexa, additional, Milman, Nataliya, additional, Shea, Beverley, additional, Tómasson, Gunnar, additional, Tugwell, Peter, additional, Direskeneli, Haner, additional, and Merkel, Peter A., additional

Published
2019
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29. Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise

Author

Aydin, Sibel Z, Direskeneli, Haner, Merkel, Peter A, International Delphi On Disease Activity Assessment In Large-Vessel Vasculitis, and Apollo - University of Cambridge Repository

Subjects
OUTCOMES, Delphi Technique, Giant Cell Arteritis, VASCULITIS, Humans, TAKAYASU ARTERITIS, LARGE VESSEL, Severity of Illness Index
Abstract

OBJECTIVE: To arrive at consensus for candidate outcomes for disease activity assessment in large-vessel vasculitis (LVV) in clinical trials. METHODS: A Delphi survey including 99 items was circulated among international experts for 3 rounds. RESULTS: Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging. CONCLUSION: This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes.

Published
2017

30. Options for Assessing Joints and Entheses in Psoriatic Arthritis by Ultrasonography and Magnetic Resonance Imaging:How to Move Forward

Author

Eder, Lihi, Aydin, Sibel Z., Kaeley, Gurjit S., Maksymowych, Walter P., Østergaard, Mikkel, Eder, Lihi, Aydin, Sibel Z., Kaeley, Gurjit S., Maksymowych, Walter P., and Østergaard, Mikkel

Abstract

Psoriatic arthritis (PsA) is a heterogeneous disease with various manifestations of musculoskeletal inflammation. Recent advances in imaging, including ultrasound (US) and magnetic resonance imaging (MRI), allow for the accurate evaluation of the extent of inflammation and damage in the peripheral joints, spine, and entheses. The development and validation of outcome measures are critical steps in creating standardized evaluations of musculoskeletal inflammation and damage in psoriatic patients. At the 2017 meeting of the Group for Research and Assessment of Psoriasis and PsA (GRAPPA), recent work on outcome measures from the GRAPPA US and MRI working groups was summarized. The GRAPPA US group has been developing and validating a sonographic enthesitis scoring system in PsA. The GRAPPA MRI group focuses on the evaluation of whole-body MRI for the assessment of musculoskeletal inflammation in the joints and entheses in patients with PsA.

Published
2018

31. Correction: Corrigendum: Analysis of the common genetic component of large-vessel vasculitides through a meta-Immunochip strategy

Author

Castañeda, Santos, Ytterberg, Steven R, Warrington, Kenneth J, Sreih, Antoine G, Spiera, Robert, Seo, Philip, Pagnoux, Christian, Moreland, Larry, Monach, Paul A, McKinnon-Maksimowicz, Kathleen, McAlear, Carol A, Langford, Carol A, Koening, Curry L, Khalidi, Nader A, Hoffman, Gary S, Forbess, Lindsay J, Cuthbertson, David, Chung, Sharon A, Carette, Simon, Karaaslan, Yasar, Ates, Askin, Ozbalkan, Zeynep, Cobankara, Veli, Kaşifoğlu, Timuçin, Alibaz-Oner, Fatma, Aydin, Sibel Z, Yentür, Sibel P, Inanc, Murat, Kamali, Sevil, Akkoc, Nurullah, Onen, FATOŞ, Akar, Servet, Pamuk, Ömer N, Kiraz, Sedat, Karadag, Omer, Duzgun, Nurşen, Bıcakcıgil, Muge, Ozturk, Mehmet A, Keser, Gokhan, Aksu, Kenan, Te Ozer, Hüseyin, Erken, Eren, Tunc, Ercan, Fresko, Izzet, Seyahi, Emire, Dalkilic, Ediz, Kısacık, Bünyamin, Yazici, Ayten, Cefle, Ayse, Mesut Onat, Ahmet, Cimmino, Marco A, Govoni, Marcello, Beretta, Lorenzo, Ramirez, Giuseppe A, Emmi, Giacomo, Addimanda, Olga, Pazzola, Giulia, Muratore, Francesco, Bonatti, Francesco, Santilli, Daniele, Gianfreda, Davide, Lunardi, Claudio, Soriano, Alessandra, Martínez-Taboada, Víctor Manuel, Prieto-González, Sergio, Blanco, Ricardo, Fanlo Mateo, Patricia, Sanchez Pernaute, Olga, Callejas, José Luis, Ríos Fernández, Raquel, Ortego-Centeno, Norberto, Guijarro Rojas, Mercedes, García-Villanueva, María Jesús, Ramentol-Sintas, Marc, Corbera-Bellalta, Marc, Pérez-Conesa, Mercedes, Sáez-Comet, Luis, Alegre-Sancho, Juan J, Sánchez-Martín, Julio, Miranda-Filloy, José A, Tío, Laura, Monfort, Jordi, Narváez, Javier, Martínez-Zapico, Aleida, Caminal-Montero, Luis, Díaz-López, J Bernardino, Morado, Inmaculada C, Martínez, Lina, López-Longo, Francisco J, de Miguel, Eugenio, Vicente, Esther F, Román, José A, Grau, Elena, Raya, Enrique, Gómez-Vaquero, Carmen, Sopeña, Bernardo, Marí-Alfonso, Begoña, Escalante, Begoña, Rodríguez-Rodríguez, Luis, Fernández-Gutiérrez, Benjamín, Ordóñez-Cañizares, M Carmen, Fernández-Nebro, Antonio, Vuelta, Ana Belén Madroñero, Hidalgo-Conde, Ana, Unzurrunzaga, Ainhoa, Martínez-Berriochoa, Agustín, Sawalha, Amr H, Martín, Javier, González-Gay, Miguel A, Salvarani, Carlo, Boiardi, Luigi, Merkel, Peter A, Direskeneli, Haner, Carmona, F David, Coit, Patrick, Saruhan-Direskeneli, Güher, Hernández-Rodríguez, José, Cid, María C, Solans, Roser, and Vaglio, Augusto

Subjects
03 medical and health sciences, 0302 clinical medicine, Multidisciplinary, Geography, Component (UML), 030221 ophthalmology & optometry, Library science, Large vessel, skin and connective tissue diseases, Article, 030217 neurology & neurosurgery
Abstract

Giant cell arteritis (GCA) and Takayasu’s arteritis (TAK) are major forms of large-vessel vasculitis (LVV) that share clinical features. To evaluate their genetic similarities, we analysed Immunochip genotyping data from 1,434 LVV patients and 3,814 unaffected controls. Genetic pleiotropy was also estimated. The HLA region harboured the main disease-specific associations. GCA was mostly associated with class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostly associated with class I genes (HLA-B/MICA). Both the statistical significance and effect size of the HLA signals were considerably reduced in the cross-disease meta-analysis in comparison with the analysis of GCA and TAK separately. Consequently, no significant genetic correlation between these two diseases was observed when HLA variants were tested. Outside the HLA region, only one polymorphism located nearby the IL12B gene surpassed the study-wide significance threshold in the meta-analysis of the discovery datasets (rs755374, P = 7.54E-07; ORGCA = 1.19, ORTAK = 1.50). This marker was confirmed as novel GCA risk factor using four additional cohorts (PGCA = 5.52E-04, ORGCA = 1.16). Taken together, our results provide evidence of strong genetic differences between GCA and TAK in the HLA. Outside this region, common susceptibility factors were suggested, especially within the IL12B locus.

Published
2017

35. The Ottawa Panel guidelines on programmes involving therapeutic exercise for the management of hand osteoarthritis

Author

Brosseau, Lucie, primary, Thevenot, Odette, additional, MacKiddie, Olivia, additional, Taki, Jade, additional, Wells, George A, additional, Guitard, Paulette, additional, Léonard, Guillaume, additional, Paquet, Nicole, additional, Aydin, Sibel Z, additional, Toupin-April, Karine, additional, Cavallo, Sabrina, additional, Moe, Rikke Helene, additional, Shaikh, Kamran, additional, Gifford, Wendy, additional, Loew, Laurianne, additional, De Angelis, Gino, additional, Shallwani, Shirin Mehdi, additional, Aburub, Ala’ S, additional, Mizusaki Imoto, Aline, additional, Rahman, Prinon, additional, Álvarez Gallardo, Inmaculada C, additional, Cosic, Milkana Borges, additional, Østerås, Nina, additional, Lue, Sabrina, additional, Hamasaki, Tokiko, additional, Gaudreault, Nathaly, additional, Towheed, Tanveer E, additional, Koppikar, Sahil, additional, Kjeken, Ingvild, additional, Mahendira, Dharini, additional, Kenny, Glen P, additional, Paterson, Gail, additional, Westby, Marie, additional, Laferrière, Lucie, additional, and Longchamp, Guy, additional

Published
2018
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37. Assessment of disease activity in large-vessel vasculitis:Results of an international delphi exercise

Author

Aydin, Sibel Z., Direskeneli, Haner, Merkel, Peter A., Toloza, Sergio, Blockmans, Daniel, Sato, Emilia Inoue, Baslund, Bo, Warrington, Kenneth, Yazici, Yusuf, Ytterberg, Steven, Aydin, Sibel Z., Direskeneli, Haner, Merkel, Peter A., Toloza, Sergio, Blockmans, Daniel, Sato, Emilia Inoue, Baslund, Bo, Warrington, Kenneth, Yazici, Yusuf, and Ytterberg, Steven

Abstract

Objective. To arrive at consensus for candidate outcomes for disease activity assessment in largevessel vasculitis (LVV) in clinical trials. Methods.A Delphi survey including 99 items was circulated among international experts for 3 rounds. Results. Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging. Conclusion. This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes.

Published
2017

38. Development of a Core Set of Outcome Measures for Large-vessel Vasculitis: Report from OMERACT 2016

Author

Sreih, Antoine G., primary, Alibaz-Oner, Fatma, additional, Kermani, Tanaz A., additional, Aydin, Sibel Z., additional, Cronholm, Peter F., additional, Davis, Trocon, additional, Easley, Ebony, additional, Gul, Ahmet, additional, Mahr, Alfred, additional, McAlear, Carol A., additional, Milman, Nataliya, additional, Robson, Joanna C., additional, Tomasson, Gunnar, additional, Direskeneli, Haner, additional, and Merkel, Peter A., additional

Published
2017
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40. Genome-wide association study identifies susceptibility loci in IL6, RPS9/LILRB3, and an intergenic locus on chromosome 21q22 in Takayasu’s arteritis

Author

Renauer, Paul, Saruhan-Direskeneli, Guher, Coit, Patrick, Adler, Adam, Aksu, Kenan, Keser, Gokhan, Alibaz-Oner, Fatma, Aydin, Sibel Z., Kamali, Sevil, Inanc, Murat, Carette, Simon, Cuthbertson, David, Hoffman, Gary S., Akar, Servet, Onen, Fatos, Akkoc, Nurullah, Khalidi, Nader A., Koening, Curry, Karadag, Omer, Kiraz, Sedat, Langford, Carol A., Maksimowicz-McKinnon, Kathleen, McAlear, Carol A., Ozbalkan, Zeynep, Ates, Askin, Karaaslan, Yasar, Duzgun, Nursen, Monach, Paul A., Ozer, Huseyin TE, Erken, Eren, Ozturk, Mehmet A., Yazici, Ayten, Cefle, Ayse, Onat, A. Mesut, Kisacik, Bunyamin, Pagnoux, Christian, Kasifoglu, Timucin, Seyahi, Emire, Fresko, Izzet, Seo, Philip, Sreih, Antoine, Warrington, Kenneth J., Ytterberg, Steven R., Cobankara, Veli, Cunninghame-Graham, Deborah S., Vyse, Timothy J., Pamuk, Omer N., Tunc, Ercan, Dalkilic, Ediz, Bicakcigil, Muge, Yentur, Sibel P., Wren, Jonathan D., Merkel, Peter A., Direskeneli, Haner, and Sawalha, Amr H.

Subjects
Ribosomal Proteins, Turkey, Chromosomes, Human, Pair 21, Interleukin-6, Ribosomal Protein S9, Takayasu Arteritis, Article, White People, Cohort Studies, Antigens, CD, Case-Control Studies, North America, Odds Ratio, Humans, Genetic Predisposition to Disease, Receptors, Immunologic, Genome-Wide Association Study
Abstract

Takayasu arteritis is a rare large vessel vasculitis with incompletely understood etiology. This study was undertaken to perform the first unbiased genome-wide association analysis of Takayasu arteritis.Two independent cohorts of patients with Takayasu arteritis from Turkey and North America were included in our study. The Turkish cohort consisted of 559 patients and 489 controls, and the North American cohort consisted of 134 patients and 1,047 controls of European ancestry. Genotyping was performed using the Omni1-Quad and Omni2.5 genotyping arrays. Genotyping data were subjected to rigorous quality control measures and subsequently analyzed to discover genetic susceptibility loci for Takayasu arteritis.We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10(-10)). The genetic susceptibility locus in RPS9/LILRB3 lies within the leukocyte receptor complex gene cluster on chromosome 19q13.4, and the disease risk variant in this locus correlates with reduced expression of multiple genes including the inhibitory leukocyte immunoglobulin-like receptor gene LILRB3 (P = 2.29 × 10(-8)). In addition, we identified candidate susceptibility genes with suggestive levels of association (P1 × 10(-5)) with Takayasu arteritis, including PCSK5, LILRA3, PPM1G/NRBP1, and PTK2B.Our findings indicate novel genetic susceptibility loci for Takayasu arteritis and uncover potentially important aspects of the pathophysiology of this form of vasculitis.

Published
2015

41. Impact of Having Family History of Psoriasis or Psoriatic Arthritis on Psoriatic Disease

Author

Solmaz, Dilek, Bakirci, Sibel, Kimyon, Gezmis, Gunal, Esen K., Dogru, Atalay, Bayindir, Ozun, Dalkilic, Ediz, Ozisler, Cem, Can, Meryem, Akar, Servet, Cetin, Gozde Y., Yavuz, Sule, Kilic, Levent, Tarhan, Emine F., Kucuksahin, Orhan, Omma, Ahmet, Gonullu, Emel, Yildiz, Fatih, Ersozlu, Emine D., Cinar, Muhammet, Al‐Onazi, Atallah, Erden, Abdulsamet, Tufan, Muge A., Yilmaz, Sema, Pehlevan, Seval, Kalyoncu, Umut, and Aydin, Sibel Z.

Abstract

Psoriatic arthritis (PsA) has a genetic background. Approximately 40% of patients with psoriasis or PsA have a family history of psoriasis or PsA, which may affect disease features. The aim of this study was to assess the effects of family history of psoriasis and PsA on disease phenotypes. Data from 1,393 patients recruited in the longitudinal, multicenter Psoriatic Arthritis International Database were analyzed. The effects of family history of psoriasis and/or PsA on characteristics of psoriasis and PsA were investigated using logistic regression. A total of 444 patients (31.9%) had a family history of psoriasis and/or PsA. These patients were more frequently women, had earlier onset of psoriasis, more frequent nail disease, enthesitis, and deformities, and less frequently achieved minimal disease activity. Among 444 patients, 335 only had psoriasis in their family, 74 had PsA, and 35 patients were not certain about having PsA and psoriasis in their family, so they were excluded from further analysis. In the multivariate analysis, family history of psoriasis was associated with younger age at onset of psoriasis (odds ratio [OR] 0.976) and presence of enthesitis (OR1.931), whereas family history of PsA was associated with lower risk of plaque psoriasis (OR0.417) and higher risk of deformities (OR2.557). Family history of PsA versus psoriasis showed increased risk of deformities (OR2.143) and lower risk of plaque psoriasis (OR0.324). Family history of psoriasis and PsA impacts skin phenotypes, musculoskeletal features, and disease severity. The link between family history of psoriasis/PsA and pustular/plaque phenotypes may point to a different genetic background and pathogenic mechanisms in these subsets.

Published
2020
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44. Current Status, Goals, and Research Agenda for Outcome Measures Development in Behçet Syndrome: Report from OMERACT 2014

Author

Hatemi, Gulen, primary, Ozguler, Yesim, additional, Direskeneli, Haner, additional, Mahr, Alfred, additional, Gul, Ahmet, additional, Levi, Virna, additional, Aydin, Sibel Z., additional, Mumcu, Gonca, additional, Sertel-Berk, Ozlem, additional, Stevens, Randall M., additional, Yazici, Hasan, additional, and Merkel, Peter A., additional

Published
2015
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45. Assessment of Patients with Takayasu Arteritis in Routine Practice with Indian Takayasu Clinical Activity Score

Author

Alibaz-Oner, Fatma, primary, Aydin, Sibel Z., additional, Akar, Servet, additional, Aksu, Kenan, additional, Kamali, Sevil, additional, Yucel, Eftal, additional, Karadag, Omer, additional, Ozer, Huseyin, additional, Kiraz, Sedat, additional, Onen, Fatos, additional, Inanc, Murat, additional, Keser, Gokhan, additional, Akkoc, Nurullah, additional, and Direskeneli, Haner, additional

Published
2015
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46. Identification of Susceptibility Loci inIL6,RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study

Author

Renauer, Paul A., primary, Saruhan-Direskeneli, Guher, additional, Coit, Patrick, additional, Adler, Adam, additional, Aksu, Kenan, additional, Keser, Gokhan, additional, Alibaz-Oner, Fatma, additional, Aydin, Sibel Z., additional, Kamali, Sevil, additional, Inanc, Murat, additional, Carette, Simon, additional, Cuthbertson, David, additional, Hoffman, Gary S., additional, Akar, Servet, additional, Onen, Fatos, additional, Akkoc, Nurullah, additional, Khalidi, Nader A., additional, Koening, Curry, additional, Karadag, Omer, additional, Kiraz, Sedat, additional, Langford, Carol A., additional, Maksimowicz-McKinnon, Kathleen, additional, McAlear, Carol A., additional, Ozbalkan, Zeynep, additional, Ates, Askin, additional, Karaaslan, Yasar, additional, Duzgun, Nursen, additional, Monach, Paul A., additional, Ozer, Huseyin T. E., additional, Erken, Eren, additional, Ozturk, Mehmet A., additional, Yazici, Ayten, additional, Cefle, Ayse, additional, Onat, Ahmet Mesut, additional, Kisacik, Bunyamin, additional, Pagnoux, Christian, additional, Kasifoglu, Timucin, additional, Seyahi, Emire, additional, Fresko, Izzet, additional, Seo, Philip, additional, Sreih, Antoine G., additional, Warrington, Kenneth J., additional, Ytterberg, Steven R., additional, Cobankara, Veli, additional, Cunninghame-Graham, Deborah S., additional, Vyse, Timothy J., additional, Pamuk, Omer N., additional, Tunc, S. Ercan, additional, Dalkilic, Ediz, additional, Bicakcigil, Muge, additional, Yentur, Sibel P., additional, Wren, Jonathan D., additional, Merkel, Peter A., additional, Direskeneli, Haner, additional, and Sawalha, Amr H., additional

Published
2015
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49. Current Status of Outcome Measure Development in Vasculitis

Author

Merkel, Peter A., primary, Aydin, Sibel Z., additional, Boers, Maarten, additional, Cornell, Christina, additional, Direskeneli, Haner, additional, Gebhart, Don, additional, Hatemi, Gulen, additional, Luqmani, Raashid, additional, Matteson, Eric L., additional, Milman, Nataliya, additional, Robson, Joanna, additional, Seo, Philip, additional, and Tomasson, Gunnar, additional

Published
2014
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