108 results on '"Aydin, Semiha"'
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2. Angststoornissen bij jongeren herkennen
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Aydin, Semiha, Crone, Matty, Siebelink, Bart, Vermeiren, Robert, Numans, Mattijs, and Westenberg, Michiel
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- 2021
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3. Substance Use Initiation, Particularly Alcohol, in Drug-Naive Adolescents: Possible Predictors and Consequences From a Large Cohort Naturalistic Study
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Rapp, Michael, Artiges, Eric, Schneider, Sophia, Paus, Tomas, Barbot, Alexis, Barker, Gareth, Bokde, Arun, Vetter, Nora, Büchel, Christian, Cattrell, Anna, Constant, Patrick, Gowland, Penny, Crombag, Hans, Dalley, Jeffrey, Decideur, Benjamin, Spranger, Tade, Ripley, Tamzin, Heym, Nadja, Flor, Herta, Sommer, Wolfgang, Fuchs, Birgit, Gallinat, Jürgen, Garavan, Hugh, Spanagel, Rainer, Kaviani, Mehri, Heinrichs, Bert, Andreas Heinz, Subramaniam, Naresh, Jia, Tianye, Ihlenfeld, Albrecht, Ireland, James, Ittermann, Bernd, Conrod, Patricia, Banaschewski, Tobias, Jones, Jennifer, Klaassen, Arno, Lalanne, Christophe, Lanzerath, Dirk, Lawrence, Claire, Lemaitre, Hervé, Desrivieres, Sylvane, Mallik, Catherine, Mann, Karl, Mar, Adam, Martinez-Medina, Lourdes, Martinot, Jean-Luc, Mennigen, Eva, Mesquita de Carvahlo, Fabiana, Schwartz, Yannick, Bruehl, Ruediger, Müller, Kathrin, Nees, Frauke, Nymberg, Charlotte, Lathrop, Mark, Robbins, Trevor, Pausova, Zdenka, Pentilla, Jani, Biondo, Francesca, Poline, Jean-Baptiste, Poustka, Luise, Millenet, Sabina, Smolka, Michael, Fröhner, Juliane, Struve, Maren, Williams, Steve, Hübner, Thomas, Bromberg, Uli, Aydin, Semiha, Rogers, John, Romanowski, Alexander, Schmäl, Christine, Schmidt, Dirk, Ripke, Stephan, Arroyo, Mercedes, Schubert, Florian, Pena-Oliver, Yolanda, Fauth-Bühler, Mira, Mignon, Xavier, Whelan, Robert, Speiser, Claudia, Fadai, Tahmine, Stephens, Dai, Ströhle, Andreas, Paillere, Marie-Laure, Strache, Nicole, Theobald, David, Jurk, Sarah, Vulser, Helene, Miranda, Ruben, Yacubilin, Juliana, Frouin, Vincent, Genauck, Alexander, Parchetka, Caroline, Gemmeke, Isabel, Kruschwitz, Johann, WeiB, Katharina, Walter, Henrik, Feng, Jianfeng, Papadopoulos, Dimitri, Filippi, Irina, Ing, Alex, Ruggeri, Barbara, Xu, Bing, Macare, Christine, Chu, Congying, Hanratty, Eanna, Burke Quinlan, Erin, Robert, Gabriel, Schumann, Gunter, Yu, Tao, Ziesch, Veronika, Stedman, Alicia, Ivanov, Iliyan, Parvaz, Muhammad A., Velthorst, Eva, Shaik, Riaz B., Sandin, Sven, Gan, Gabriela, Spechler, Philip, Albaugh, Matthew D., Chaarani, Bader, Mackey, Scott, Bokde, Arun L.W., Quinlan, Erin Burke, Desrivières, Sylvane, Grigis, Antoine, Heinz, Andreas, Paillère Martinot, Marie-Laure, Lemaitre, Herve, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Hohmann, Sarah, Fröhner, Juliane H., and Smolka, Michael N.
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- 2021
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4. Reward Versus Nonreward Sensitivity of the Medial Versus Lateral Orbitofrontal Cortex Relates to the Severity of Depressive Symptoms
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Artiges, Eric, Aydin, Semiha, Banaschewski, Tobias, Barbot, Alexis, Barker, Gareth, Becker, Andreas, Bezivin-Frere, Pauline, Biondo, Francesca, Bokde, Arun, Büchel, Christian, Chu, Congying, Conrod, Patricia, Daedelow, Laura, Dalley, Jeffrey, Desrivieres, Sylvane, Dooley, Eoin, Filippi, Irina, Fillmer, Ariane, Flor, Herta, Fröhner, Juliane, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Grimmer, Yvonne, Heinz, Andreas, Hohmann, Sarah, Ihlenfeld, Albrecht, Ing, Alex, Isensee, Corinna, Ittermann, Bernd, Jia, Tianye, Lemaitre, Hervé, Lethbridge, Emma, Martinot, Jean-Luc, Millenet, Sabina, Miller, Sarah, Miranda, Ruben, Nees, Frauke, Paillere, Marie-Laure, Papadopoulos, Dimitri, Paus, Tomáš, Pausova, Zdenka, Pentilla, Jani, Poline, Jean-Baptiste, Poustka, Luise, Burke, Erin, Rapp, Michael, Robbins, Trevor, Robert, Gabriel, Rogers, John, Ruggeri, Barbara, Schumann, Gunter, Smolka, Michael, Stringaris, Argyris, van Noort, Betteke, Walter, Henrik, Whelan, Robert, Simon, Roux, Williams, Steve, Zhang, Yuning, Xie, Chao, Rolls, Edmund T., Robbins, Trevor W., Sahakian, Barbara J., Zhang, Jie, Liu, Zhaowen, Cheng, Wei, Luo, Qiang, Zac Lo, Chun-Yi, Wang, He, Barker, Gareth J., Bokde, Arun L.W., Quinlan, Erin Burke, Desrivières, Sylvane, Grigis, Antoine, Paillère Martinot, Marie-Laure, Orfanos, Dimitri Papadopoulos, Fröhner, Juliane H., Smolka, Michael N., and Feng, Jianfeng
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- 2021
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5. Neural Correlates of Adolescent Irritability and Its Comorbidity With Psychiatric Disorders
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Rapp, Dr. Michael, Artiges, Dr. Eric, Schneider, Sophia, Bach, Christine, Paus, Dr. Tomas, Barbot, Alexis, Barker, Dr. Gareth, Bokde, Dr. Arun, Vetter, Dr. Nora, Büchel, Dr. Christian, Cattrell, Dr. Anna, Constant, Patrick, Gowland, Penny, Crombag, Dr. Hans, Czech, Katharina, Dalley, Dr. Jeffrey, Decideur, Benjamin, Spranger, Tade, Ripley, Dr. Tamzin, Heym, Dr. Nadja, Flor, Herta, Sommer, Dr. Wolfgang, Fuchs, Birgit, Gallinat, Dr. Jürgen, Garavan, Dr. Hugh, Spanagel, Dr. Rainer, Kaviani, Mehri, Heinrichs, Dr. Bert, Heinz, Dr. Andreas, Subramaniam, Naresh, Jia, Dr. Tianye, Ihlenfeld, Albrecht, Ireland, James, Ittermann, Dr. Bernd, Conrod, Dr. Patricia, Banaschewski, Dr. Tobias, Jones, Jennifer, Klaassen, Dr. Arno, Lalanne, Christophe, Lanzerath, Dr. Dirk, Lawrence, Dr. Claire, Lemaitre, Dr. Hervé, Desrivieres, Dr. Sylvane, Mallik, Catherine, Mann, Dr. Karl, Mar, Dr. Adam, Martinez-Medina, Lourdes, Martinot, Dr. Jean-Luc, Mennigen, Eva, Mesquita de Carvahlo, Dr. Fabiana, Schwartz, Yannick, Bruehl, Dr. Ruediger, Müller, Kathrin, Nees, Frauke, Nymberg, Charlotte, Lathrop, Dr. Mark, Robbins, Dr. Trevor, Pausova, Dr. Zdenka, Pentilla, Dr. Jani, Biondo, Dr. Francesca, Poline, Dr. Jean-Baptiste, Poustka, Dr. Luise, Millenet, Sabina, Smolka, Dr. Michael, Fröhner, Juliane, Struve, Dr. Maren, Williams, Dr. Steve, Hübner, Dr. Thomas, Bromberg, Uli, Aydin, Semiha, Rogers, John, Romanowski, Alexander, Schmäl, Dr. Christine, Schmidt, Dirk, Ripke, Stephan, Arroyo, Dr. Mercedes, Schubert, Dr. Florian, Pena-Oliver, Dr. Yolanda, Fauth-Bühler, Mira, Mignon, Xavier, Whelan, Dr. Robert, Speiser, Dr. Claudia, Fadai, Tahmine, Stephens, Dr. Dai, Ströhle, Dr. Andreas, Paillere, Dr. Marie-Laure, Strache, Nicole, Theobald, David, Jurk, Sarah, Vulser, Dr. Helene, Miranda, Ruben, Yacubilin, Dr. Juliana, Frouin, Vincent, Genauck, Alexander, Parchetka, Caroline, Gemmeke, Isabel, Kruschwitz, Johann, Weiss, Katharina, Walter, Dr. Henrik, Feng, Jianfeng, Papadopoulos, Dimitri, Filippi, Irina, Ing, Alex, Ruggeri, Dr. Barbara, Xu, Bing, Macare, Christine, Chu, Dr. Congying, Hanratty, Eanna, Burke Quinlan, Dr. Erin, Robert, Dr. Gabriel, Schumann, Dr. Gunter, Yu, Dr. Tao, Ziesch, Veronika, Stedman, Alicia, Chaarani, Bader, Kan, Kees-Jan, Mackey, Scott, Spechler, Philip A., Potter, Alexandra, Banaschewski, Tobias, Bokde, Arun L.W., Büchel, Christian, Cattrell, Anna, Conrod, Patricia J., Desrivières, Sylvane, Gallinat, Jürgen, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Paus, Tomáš, Poustka, Luise, Smolka, Michael N., Walter, Henrik, Whelan, Robert, Stringaris, Argyris, Higgins, Stephen T., Schumann, Gunter, Garavan, Hugh, and Althoff, Robert R.
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- 2020
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6. Correlation of striatal dopamine D2/3 receptor availability with GABA level in the anterior cingulate cortex in healthy controls but not in alcohol‐dependent subjects and individuals at high risk: A multimodal magnetic resonance spectroscopy and positron emission tomography study
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Spitta, Gianna, Gleich, Tobias, Rosenthal, Annika, Schubert, Florian, Aydin, Semiha, Heinz, Andreas, Buchert, Ralph, and Gallinat, Jürgen
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DOPAMINE receptors ,NUCLEAR magnetic resonance spectroscopy ,POSITRON emission tomography ,EMISSION spectroscopy ,GABA receptors ,CINGULATE cortex - Abstract
Background: The association of impaired dopaminergic neurotransmission with the development and maintenance of alcohol use disorder is well known. More specifically, reduced dopamine D2/3 receptors in the striatum of subjects with alcohol dependence (AD) compared to healthy controls have been found in previous studies. Furthermore, alterations of gamma‐aminobutyric acid (GABA) and glutamate (Glu) levels in the anterior cingulate cortex (ACC) of AD subjects have been documented in several studies. However, the interaction between cortical Glu levels and striatal dopamine D2/3 receptors has not been investigated in AD thus far. Methods: This study investigated dopamine D2/3 receptor availability via 18F‐fallypride positron emission tomography (PET) and GABA as well as Glu levels via magnetic resonance spectroscopy (MRS) in 19 detoxified AD subjects, 18 healthy controls (low risk, LR) controls and 19 individuals at high risk (HR) for developing AD, carefully matched for sex, age and smoking status. Results: We found a significant negative correlation between GABA levels in the ACC and dopamine D2/3 receptor availability in the associative striatum of LR but not in AD or HR individuals. Contrary to our expectations, we did not observe a correlation between Glu concentrations in the ACC and striatal D2/3 receptor availability. Conclusions: The results may reflect potential regulatory cortical mechanisms on mesolimbic dopamine receptors and their disruption in AD and individuals at high risk, mirroring complex neurotransmitter interactions associated with the pathogenesis of addiction. This is the first study combining 18F‐fallypride PET and MRS in AD subjects and individuals at high risk. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Cannabis-Associated Psychotic-like Experiences Are Mediated by Developmental Changes in the Parahippocampal Gyrus
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Rapp, Michael, Artiges, Eric, Schneider, Sophia, Bach, Christine, Paus, Tomas, Barbot, Alexis, Barker, Gareth, Bokde, Arun, Vetter, Nora, Büchel, Christian, Cattrell, Anna, Constant, Patrick, Gowland, Penny, Crombag, Hans, Czech, Katharina, Dalley, Jeffrey, Decideur, Benjamin, Spranger, Tade, Ripley, Tamzin, Heym, Nadja, Flor, Herta, Sommer, Wolfgang, Fuchs, Birgit, Gallinat, Jürgen, Garavan, Hugh, Spanagel, Rainer, Kaviani, Mehri, Heinrichs, Bert, Heinz, Andreas, Subramaniam, Naresh, Jia, Tianye, Ihlenfeld, Albrecht, Delosis, James Ireland, Ittermann, Bernd, Conrod, Patricia, Banaschewski, Tobias, Jones, Jennifer, Klaassen, Arno, Lalanne, Christophe, Lanzerath, Dirk, Lawrence, Claire, Lemaitre, Hervé, Desrivieres, Sylvane, Mallik, Catherine, Mann, Karl, Mar, Adam, Martinez-Medina, Lourdes, Martinot, Jean-Luc, Mennigen, Eva, de Carvahlo, Fabiana Mesquita, Schwartz, Yannick, Bruehl, Ruediger, Müller, Kathrin, Nees, Frauke, Nymberg, Charlotte, Lathrop, Mark, Robbins, Trevor, Pausova, Zdenka, Pentilla, Jani, Biondo, Francesca, Poline, Jean-Baptiste, Hohmann, Sarah, Poustka, Luise, Millenet, Sabina, Smolka, Michael, Fröhner, Juliane, Struve, Maren, Williams, Steve, Hübner, Thomas, Bromberg, Uli, Aydin, Semiha, Rogers, John, Romanowski, Alexander, Schmäl, Christine, Schmidt, Dirk, Ripke, Stephan, Arroyo, Mercedes, Schubert, Florian, Pena-Oliver, Yolanda, Fauth-Bühler, Mira, Mignon, Xavier, Whelan, Robert, Speiser, Claudia, Fadai, Tahmine, Stephens, Dai, Ströhle, Andreas, Paillere, Marie-Laure, Strache, Nicole, Theobald, David, Jurk, Sarah, Vulser, Helene, Miranda, Ruben, Yacubilin, Juliana, Frouin, Vincent, Genauck, Alexander, Parchetka, Caroline, Gemmeke, Isabel, Kruschwitz, Johann, WeiB, Katharina, Walter, Henrik, Feng, Jianfeng, Papadopoulos, Dimitri, Filippi, Irina, Ing, Alex, Ruggeri, Barbara, Xu, Bing, Macare, Christine, Chu, Congying, Hanratty, Eanna, Quinlan, Erin Burke, Robert, Gabriel, Schumann, Gunter, Yu, Tao, Ziesch, Veronika, Stedman, Alicia, Zhu, Liping, Desrivières, Sylvane, Bi, Yan, Bokde, Arun L.W., Liu, ChuanXin, Ji, Lei, Ren, Decheng, Du, Li, Hou, Binyin, Paillère Martinot, Marie-Laure, Orfanos, Dimitri Papadopoulos, Luo, Qiang, Smolka, Michael N., Vetter, Nora C., Lei, Cai, Fröhner, Juliane H., He, Guang, and He, Lin
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- 2020
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8. Associations between blood‐based biomarkers and other outcomes related to Alzheimer’s disease
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Göschel, Laura, primary, Dell'Orco, Andrea, additional, Hoede, Patty, additional, Koertvelyessy, Peter, additional, Fillmer, Ariane, additional, Aydin, Semiha, additional, Cano, Stefan, additional, Melin, Jeanette, additional, Pendrill, Leslie, additional, Lehmann, Sylvain, additional, Ittermann, Bernd, additional, Teunissen, Charlotte E., additional, and Flöel, Agnes, additional
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- 2023
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9. Macromolecule modelling for improved metabolite quantification using short echo time brain1H MRS at 3 T and 7 T: The PRaMM Model
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Dell’Orco, Andrea, primary, Riemann, Layla Tabea, additional, Ellison, Stephen L. R., additional, Aydin, Semiha, additional, Göschel, Laura, additional, Tietze, Anna, additional, Scheel, Michael, additional, and Fillmer, Ariane, additional
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- 2023
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10. Neural Correlates of Failed Inhibitory Control as an Early Marker of Disordered Eating in Adolescents
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Rapp, Michael, Artiges, Eric, Schneider, Sophia, Bach, Christine, Paus, Tomas, Barbot, Alexis, Gareth Barker, Bokde, Arun, Vetter, Nora, Büchel, Christian, Cattrell, Anna, Constant, Patrick, Gowland, Penny, Crombag, Hans, Czech, Katharina, Dalley, Jeffrey, Decideur, Benjamin, Spranger, Tade, Ripley, Tamzin, Heym, Nadja, Flor, Herta, Sommer, Wolfgang, Fuchs, Birgit, Gallinat, Jürgen, Spanagel, Rainer, Kaviani, Mehri, Heinrichs, Bert, Andreas Heinz, Subramaniam, Naresh, Jia, Tianye, Ihlenfeld, Albrecht, Ireland, James, Ittermann, Bernd, Conrod, Patricia, Banaschewski, Tobias, Jones, Jennifer, Klaassen, Arno, Lalanne, Christophe, Lanzerath, Dirk, Lawrence, Claire, Lemaitre, Hervé, Desrivieres, Sylvane, Mallik, Catherine, Karl Mann, Mar, Adam, Martinez-Medina, Lourdes, Jean-Luc Martinot, Mennigen, Eva, Mesquita de Carvahlo, Fabiana, Schwartz, Yannick, Bruehl, Ruediger, Müller, Kathrin, Nees, Frauke, Nymberg, Charlotte, Lathrop, Mark, Trevor Robbins, Pausova, Zdenka, Jani Pentilla, Biondo, Francesca, Jean-Baptiste Poline, Hohmann, Sarah, Poustka, Luise, Millenet, Sabina, Michael Smolka, Fröhner, Juliane, Struve, Maren, Steve Williams, Hübner, Thomas, Bromberg, Uli, Aydin, Semiha, Rogers, John, Romanowski, Alexander, Schmäl, Christine, Schmidt, Dirk, Ripke, Stephan, Arroyo, Mercedes, Schubert, Florian, Pena-Oliver, Yolanda, Fauth-Bühler, Mira, Mignon, Xavier, Whelan, Robert, Speiser, Claudia, Fadai, Tahmine, Dai Stephens, Ströhle, Andreas, Paillere, Marie-Laure, Strache, Nicole, Theobald, David, Jurk, Sarah, Vulser, Helene, Miranda, Ruben, Yacubian, Juliana, Frouin, Vincent, Genauck, Alexander, Parchetka, Caroline, Gemmeke, Isabel, Kruschwitz, Johann, Weiß, Katharina, Walter, Henrik, Feng, Jianfeng, Papadopoulos, Dimitri, Filippi, Irina, Ing, Alex, Ruggeri, Barbara, Xu, Bing, Macare, Christine, Chu, Congying, Hanratty, Eanna, Burke Quinlan, Erin, Robert, Gabriel, Schumann, Gunter, Yu, Tao, Ziesch, Veronika, Stedman, Alicia, Bartholdy, Savani, O’Daly, Owen G., Campbell, Iain C., Barker, Gareth, Bokde, Arun L.W., Quinlan, Erin Burke, Desrivières, Sylvane, Garavan, Hugh, Heinz, Andreas, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Orfanos, Dimitri Papadopoulos, Fröhner, Juliane H., Smolka, Michael N., and Schmidt, Ulrike
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- 2019
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11. 7T Amygdala and Hippocampus Subfields in Volumetry-Based Associations with Memory: A 3-Year Follow-Up Study of Early Alzheimer's Disease
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Göschel, Laura, primary, Kurz, Lea, additional, Dell’Orco, Andrea, additional, Köbe, Theresa, additional, Körtvélyessy, Peter, additional, Fillmer, Ariane, additional, Aydin, Semiha, additional, Riemann, Layla Tabea, additional, Wang, Hui, additional, Ittermann, Bernd, additional, Grittner, Ulrike, additional, and Flöel, Agnes, additional
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- 2023
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12. Associations between the glial marker myo‐inositol measured by 7T MRS and other AD‐relevant measures
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Göschel, Laura, primary, Fillmer, Ariane, additional, Dell'Orco, Andrea, additional, Melin, Jeanette, additional, Aydin, Semiha, additional, Kurz, Lea, additional, Riemann, Layla Tabea, additional, Wang, Hui, additional, Ittermann, Bernd, additional, Rujescu, Dan, additional, Pendrill, Leslie, additional, Köbe, Theresa, additional, and Flöel, Agnes, additional
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- 2022
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13. Synthesis, spectroscopic (FT-IR/NMR) characterization, X-ray structure and DFT studies on (E)-2-(1-phenylethylidene) hydrazinecarboximidamide nitrate hemimethanol
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Özdemir, Namık, İnkaya, Ersin, Sarıpınar, Emin, Akyüz, Lale, İlhan, İlhan Özer, Aydın, Semiha, Dinçer, Muharrem, and Büyükgüngör, Orhan
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- 2013
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14. The diagnostic process from primary care to child and adolescent mental healthcare services: the incremental value of information conveyed through referral letters, screening questionnaires and structured multi-informant assessment
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Aydin, Semiha, primary, Siebelink, Bart M., additional, Crone, Matty R., additional, van Ginkel, Joost R., additional, Numans, Mattijs E., additional, Vermeiren, Robert R. J. M., additional, and Michiel Westenberg, P., additional
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- 2022
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15. GABA concentration in superior temporal sulcus predicts gamma power and perception in the sound-induced flash illusion
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Balz, Johanna, Keil, Julian, Roa Romero, Yadira, Mekle, Ralf, Schubert, Florian, Aydin, Semiha, Ittermann, Bernd, Gallinat, Jürgen, and Senkowski, Daniel
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- 2016
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16. Differential predictors for alcohol use in adolescents as a function of familial risk
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Tschorn, Mira, Lorenz, Robert C., O’Reilly, Paul F., Reichenberg, Abraham, Quinlan, Erin B., Flor, Herta, Grigis, Antoine, Garavan, Hugh, Ittermann, Bernd, Papadopoulos Orfanos, Dimitri, Poustka, Luise, Millenet, Sabina, Smolka, Michael N., Whelan, Robert, Schumann, Gunter, Rapp, Michael A., Robbins, Trevor, Dalley, Jeffrey, Subramaniam, Naresh, Theobald, David, Mann, Karl, Bach, Christiane, Struve, Maren, Banaschewski, Tobias, Rietschel, Marcella, Spanagel, Rainer, Nees, Frauke, Fauth-Bühler, Mira, Grimmer, Yvonne, Lathrop, Mark, Heinz, Andreas, Albrecht, Lisa, Ivanov, Nikolay, Strache, Nicole, Rapp, Michael, Ströhle, Andreas, Reuter, Jan, Gallinat, Jürgen, Walter, Henrik, Gemmeke, Isabel, Genauck, Alexander, Parchetka, Caroline, Weiß, Katharina, Kruschwitz, Johann, Raffaelli, Bianca, Isci, Alev, Daedelow, Laura, Barbot, Alexis, Thyreau, Benjamin, Schwartz, Yannick, Lalanne, Christophe, Frouin, Vincent, Orfanos, Dimitri Papadopoulos, Rogers, John, Ireland, James, Lanzerath, Dirk, Feng, Jianfeng, Martinot, Jean-Luc, Bricaud, Zuleima, Briand, Fanny Gollier, LemaÎtre, Hervé, Miranda, Ruben, Artiges, Eric, Massicotte, Jessica, Martinot, Marie-Laure Paillère, Vulser, Helene, Pentillä, Jani, Filippi, Irina, Galinowski, André, Bezivin, Pauline, Cattrell, Anna, Jia, Tianye, Desrivières, Sylvane, Werts, Helen, Topper, Lauren, Reed, Laurence, Andrew, Chris, Mallik, Catherine, Ruggeri, Barbara, Nymberg, Charlotte, Barker, Gareth, Conrod, Patricia J., Smith, Lindsay, Loth, Eva, Havatzias, Stephanie, Shekarrizi, Sheyda, Kitson, Emily, Robinson, Alice, Hall, Deborah, Rubino, Chiara, Wright, Hannah, Stueber, Kerstin, Hanratty, Eanna, Kennedy, Eleanor, De Carvahlo, Fabiana Mesquita, Stringaris, Argyris, Robert, Gabriel, Ing, Alex, Macare, Christine, Xu, Bing, Yu, Tao, Quinlan, Erin Burke, Constant, Patrick, Aydin, Semiha, Brühl, Ruediger, Ihlenfeld, Albrecht, Walaszek, Bernadeta, Smolka, Michael, Hübner, Thomas, Müller, Kathrin, Ripke, Stephan, Jurk, Sarah, Mennigen, Eva, Schmidt, Dirk, Vetter, Nora, Ziesch, Veronika, Fröhner, Juliane H., Bokde, Arun L. W., Carter, Daniel, Walsh, Emily, O’Driscoll, Susanne, Agan, Maria Leonora Fatimah, McMorrow, Mairead, Nugent, Sinead, Connolly, Colm, Dooley, Eoin, Cremen, Clodagh, Jones, Jennifer, O’Keefe, John, O’Connor, Martin, Poline, Jean-Baptiste, Büchel, Christian, Bromberg, Uli, Fadai, Tahmine, Yacubian, Juliana, Schneider, Sophia, Lobatchewa, Maria, Lawrence, Claire, Newman, Craig, Head, Kay, Heym, Nadja, Gowland, Penny, Stedman, Alicia, Kaviani, Mehri, Taplin, Susannah, Stephens, Dai, Paus, Tomáš, Pausova, Zdenka, Tahmasebi, Amir, Banaschewski, Tobias [0000-0003-4595-1144], Bokde, Arun L. W. [0000-0003-0114-4914], Quinlan, Erin B. [0000-0003-2927-1632], Desrivières, Sylvane [0000-0002-9120-7060], Gowland, Penny [0000-0002-4900-4817], Martinot, Jean-Luc [0000-0002-0136-0388], Artiges, Eric [0000-0003-4461-7646], Nees, Frauke [0000-0002-7796-8234], Papadopoulos Orfanos, Dimitri [0000-0002-1242-8990], Fröhner, Juliane H. [0000-0002-8493-6396], Smolka, Michael N. [0000-0001-5398-5569], Walter, Henrik [0000-0002-9403-6121], Heinz, Andreas [0000-0001-5405-9065], Rapp, Michael A. [0000-0003-0106-966X], and Apollo - University of Cambridge Repository
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631/208 ,article ,59/36 ,45/23 ,631/378 ,631/477 ,692/699/476/5 - Abstract
Traditional models of future alcohol use in adolescents have used variable-centered approaches, predicting alcohol use from a set of variables across entire samples or populations. Following the proposition that predictive factors may vary in adolescents as a function of family history, we used a two-pronged approach by first defining clusters of familial risk, followed by prediction analyses within each cluster. Thus, for the first time in adolescents, we tested whether adolescents with a family history of drug abuse exhibit a set of predictors different from adolescents without a family history. We apply this approach to a genetic risk score and individual differences in personality, cognition, behavior (risk-taking and discounting) substance use behavior at age 14, life events, and functional brain imaging, to predict scores on the alcohol use disorders identification test (AUDIT) at age 14 and 16 in a sample of adolescents (N = 1659 at baseline, N = 1327 at follow-up) from the IMAGEN cohort, a longitudinal community-based cohort of adolescents. In the absence of familial risk (n = 616), individual differences in baseline drinking, personality measures (extraversion, negative thinking), discounting behaviors, life events, and ventral striatal activation during reward anticipation were significantly associated with future AUDIT scores, while the overall model explained 22% of the variance in future AUDIT. In the presence of familial risk (n = 711), drinking behavior at age 14, personality measures (extraversion, impulsivity), behavioral risk-taking, and life events were significantly associated with future AUDIT scores, explaining 20.1% of the overall variance. Results suggest that individual differences in personality, cognition, life events, brain function, and drinking behavior contribute differentially to the prediction of future alcohol misuse. This approach may inform more individualized preventive interventions.
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- 2021
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17. Reward Versus Nonreward Sensitivity of the Medial Versus Lateral Orbitofrontal Cortex Relates to the Severity of Depressive Symptoms
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Xie, Chao, Jia, Tianye, Rolls, Edmund T., Robbins, Trevor W., Sahakian, Barbara J., Zhang, Jie, Liu, Zhaowen, Cheng, Wei, Luo, Qiang, Zac Lo, Chun-Yi, Wang, He, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L.W., Quinlan, Erin Burke, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Hohmann, Sarah, Ittermann, Bernd, Martinot, Jean-Luc, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Poustka, Luise, Smolka, Michael N., Walter, Henrik, Whelan, Robert, Schumann, Gunter, Feng, Jianfeng, Artiges, Eric, Aydin, Semiha, Barbot, Alexis, Barker, Gareth, Becker, Andreas, Bezivin-Frere, Pauline, Biondo, Francesca, Bokde, Arun, Chu, Congying, Conrod, Patricia, Daedelow, Laura, Dalley, Jeffrey, Desrivieres, Sylvane, Dooley, Eoin, Filippi, Irina, Fillmer, Ariane, Frouin, Vincent, Grimmer, Yvonne, Ihlenfeld, Albrecht, Ing, Alex, Isensee, Corinna, Lethbridge, Emma, Millenet, Sabina, Miller, Sarah, Miranda, Ruben, Paillere, Marie-Laure, Papadopoulos, Dimitri, Pausova, Zdenka, Pentilla, Jani, Poline, Jean-Baptiste, Burke, Erin, Rapp, Michael, Robbins, Trevor, Robert, Gabriel, Rogers, John, Ruggeri, Barbara, Smolka, Michael, Stringaris, Argyris, van Noort, Betteke, Simon, Roux, Williams, Steve, and Zhang, Yuning
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nervous system ,Radiology Nuclear Medicine and imaging ,musculoskeletal, neural, and ocular physiology ,Cognitive Neuroscience ,Clinical Neurology ,psychological phenomena and processes ,Biological Psychiatry - Abstract
BackgroundThe orbitofrontal cortex (OFC) is implicated in depression. The hypothesis investigated was whether the OFC sensitivity to reward and nonreward is related to the severity of depressive symptoms.MethodsActivations in the monetary incentive delay task were measured in the IMAGEN cohort at ages 14 years (n = 1877) and 19 years (n = 1140) with a longitudinal design. Clinically relevant subgroups were compared at ages 19 (high-severity group: n = 116; low-severity group: n = 206) and 14.ResultsThe medial OFC exhibited graded activation increases to reward, and the lateral OFC had graded activation increases to nonreward. In this general population, the medial and lateral OFC activations were associated with concurrent depressive symptoms at both ages 14 and 19 years. In a stratified high-severity depressive symptom group versus control group comparison, the lateral OFC showed greater sensitivity for the magnitudes of activations related to nonreward in the high-severity group at age 19 (p = .027), and the medial OFC showed decreased sensitivity to the reward magnitudes in the high-severity group at both ages 14 (p = .002) and 19 (p = .002). In a longitudinal design, there was greater sensitivity to nonreward of the lateral OFC at age 14 for those who exhibited high depressive symptom severity later at age 19 (p = .003).ConclusionsActivations in the lateral OFC relate to sensitivity to not winning, were associated with high depressive symptom scores, and at age 14 predicted the depressive symptoms at ages 16 and 19. Activations in the medial OFC were related to sensitivity to winning, and reduced reward sensitivity was associated with concurrent high depressive symptom scores.
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- 2021
18. Cytotoxicity of three maleic anhydride copolymers and common solvents used for polymer solvation
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Karakus, Gulderen, Zengin, Haci Bayram, Polat, Zubeyde Akin, Yenidunya, Ali Fazil, and Aydin, Semiha
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- 2013
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19. Neuropsychosocial profiles of current and future adolescent alcohol misusers
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Whelan, Robert, Watts, Richard, Orr, Catherine A., Althoff, Robert R., Artiges, Eric, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Büchel, Christian, Carvalho, Fabiana M., Conrod, Patricia J., Flor, Herta, Fauth-Bühler, Mira, Frouin, Vincent, Gallinat, Juergen, Gan, Gabriela, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Lawrence, Claire, Mann, Karl, Martinot, Jean-Luc, Nees, Frauke, Ortiz, Nick, Paillère-Martinot, Marie-Laure, Paus, Tomas, Pausova, Zdenka, Rietschel, Marcella, Robbins, Trevor W., Smolka, Michael N., Ströhle, Andreas, Schumann, Gunter, Garavan, Hugh, Albrecht, Lisa, Arroyo, Mercedes, Aydin, Semiha, Bach, Christine, Barbot, Alexis, Bricaud, Zuleima, Bromberg, Uli, Bruehl, Ruediger, Cattrell, Anna, Czech, Katharina, Dalley, Jeffrey, Desrivieres, Sylvane, Fadai, Tahmine, Fuchs, Birgit, Briand, Fanny Gollier, Head, Kay, Heinrichs, Bert, Heym, Nadja, Hübner, Thomas, Ihlenfeld, Albrecht, Ireland, James, Ivanov, Nikolay, Jia, Tianye, Jones, Jennifer, Kepa, Agnes, Lanzerath, Dirk, Lathrop, Mark, Lemaitre, Hervé, Lüdemann, Katharina, Martinez-Medina, Lourdes, Mignon, Xavier, Miranda, Ruben, Müller, Kathrin, Nymberg, Charlotte, Pentilla, Jani, Poline, Jean-Baptiste, Poustka, Luise, Rapp, Michael, Ripke, Stephan, Rodehacke, Sarah, Rogers, John, Romanowski, Alexander, Ruggeri, Barbara, Schmäl, Christine, Schmidt, Dirk, Schneider, Sophia, Schroeder, Markus, Schubert, Florian, Sommer, Wolfgang, Spanagel, Rainer, Stacey, David, Steiner, Sabina, Stephens, Dai, Strache, Nicole, Struve, Maren, Tahmasebi, Amir, Topper, Lauren, Vulser, Helene, Walaszek, Bernadeta, Werts, Helen, Williams, Steve, Wong, Peng C., Yacubian, Juliana, and Ziesch., Veronika
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- 2014
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20. The IMAGEN study: a decade of imaging genetics in adolescents
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Mascarell Maričić, Lea, Walter, Henrik, Rosenthal, Annika, Ripke, Stephan, Quinlan, Erin Burke, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Bromberg, Uli, Büchel, Christian, Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Itterman, Bernd, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Hohmann, Sarah, Smolka, Michael N., Fröhner, Juliane H., Whelan, Robert, Kaminski, Jakob, Schumann, Gunter, Heinz, Andreas, Albrecht, Lisa, Andrew, Chris, Arroyo, Mercedes, Artiges, Eric, Aydin, Semiha, Bach, Christine, Barbot, Alexis, Barker, Gareth, Boddaert, Nathalie, Bokde, Arun, Bricaud, Zuleima, Bruehl, Ruediger, Cachia, Arnaud, Cattrell, Anna, Conrod, Patricia, Constant, Patrick, Dalley, Jeffrey, Decideur, Benjamin, Desrivieres, Sylvane, Fadai, Tahmine, Gallinat, Jürgen, Briand, Fanny Gollier, Gowland, Penny, Heinrichs, Bert, Heym, Nadja, Hübner, Thomas, Ireland, James, Ittermann, Bernd, Jia, Tianye, Lathrop, Mark, Lanzerath, Dirk, Lawrence, Claire, Lemaitre, Hervé, Lüdemann, Katharina, Macare, Christine, Mallik, Catherine, Mangin, Jean-François, Mann, Karl, Mennigen, Eva, de Carvahlo, Fabiana Mesquita, Mignon, Xavier, Miranda, Ruben, Müller, Kathrin, Nymberg, Charlotte, Paillere, Marie-Laure, Paus, Tomas, Pausova, Zdenka, Poline, Jean-Baptiste, Rapp, Michael, Robert, Gabriel, Reuter, Jan, Rietschel, Marcella, Robbins, Trevor, Rodehacke, Sarah, Rogers, John, Romanowski, Alexander, Ruggeri, Barbara, Schmäl, Christine, Schmidt, Dirk, Schneider, Sophia, Schumann, MarkGunter, Schubert, Florian, Schwartz, Yannick, Smolka, Michael, Sommer, Wolfgang, Spanagel, Rainer, Speiser, Claudia, Spranger, Tade, Stedman, Alicia, Steiner, Sabina, Stephens, Dai, Strache, Nicole, Ströhle, Andreas, Struve, Maren, Subramaniam, Naresh, Topper, Lauren, Williams, Steve, Yacubian, Juliana, Zilbovicius, Monica, Wong, C. Peng, Lubbe, Steven, Martinez-Medina, Lourdes, Fernandes, Alinda, and Tahmasebi, Amir
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Time Factors ,Adolescent ,Imaging genetics ,Brain Structure and Function ,Neuroimaging ,Cohort Studies ,Cellular and Molecular Neuroscience ,Reward ,Genetics ,Humans ,Psychology ,Multicenter Studies as Topic ,Generalizability theory ,Molecular Biology ,Reproducibility of Results ,Small sample ,Anticipation ,Psychiatry and Mental health ,Sample size determination ,Adolescent Behavior ,Cohort ,Brain size ,Perspective ,600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit ,Clinical psychology ,Neuroscience - Abstract
Imaging genetics offers the possibility of detecting associations between genotype and brain structure as well as function, with effect sizes potentially exceeding correlations between genotype and behavior. However, study results are often limited due to small sample sizes and methodological differences, thus reducing the reliability of findings. The IMAGEN cohort with 2000 young adolescents assessed from the age of 14 onwards tries to eliminate some of these limitations by offering a longitudinal approach and sufficient sample size for analyzing gene-environment interactions on brain structure and function. Here, we give a systematic review of IMAGEN publications since the start of the consortium. We then focus on the specific phenotype ‘drug use’ to illustrate the potential of the IMAGEN approach. We describe findings with respect to frontocortical, limbic and striatal brain volume, functional activation elicited by reward anticipation, behavioral inhibition, and affective faces, and their respective associations with drug intake. In addition to describing its strengths, we also discuss limitations of the IMAGEN study. Because of the longitudinal design and related attrition, analyses are underpowered for (epi-) genome-wide approaches due to the limited sample size. Estimating the generalizability of results requires replications in independent samples. However, such densely phenotyped longitudinal studies are still rare and alternative internal cross-validation methods (e.g., leave-one out, split-half) are also warranted. In conclusion, the IMAGEN cohort is a unique, very well characterized longitudinal sample, which helped to elucidate neurobiological mechanisms involved in complex behavior and offers the possibility to further disentangle genotype × phenotype interactions.
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- 2020
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21. The genetic architecture of the human cerebral cortex
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Grasby, Katrina L, Jahanshad, Neda, Shatokhina, Natalia, Mirza-Schreiber, Nazanin, Moreira, Jose C V, Mühleisen, Thomas W, Müller-Myhsok, Bertram, Najt, Pablo, Nakahara, Soichiro, Nho, Kwangsik, Olde Loohuis, Loes M, Orfanos, Dimitri Papadopoulos, Pearson, John F, Zsembik, Leo C P, Pitcher, Toni L, Pütz, Benno, Quidé, Yann, Ragothaman, Anjanibhargavi, Rashid, Faisal M, Reay, William R, Redlich, Ronny, Reinbold, Céline S, Repple, Jonathan, Richard, Geneviève, Thomopoulos, Sophia I, Riedel, Brandalyn C, Risacher, Shannon L, Rocha, Cristiane S, Mota, Nina Roth, Salminen, Lauren, Saremi, Arvin, Saykin, Andrew J, Schlag, Fenja, Schmaal, Lianne, Schofield, Peter R, Zhu, Alyssa H, Secolin, Rodrigo, Shapland, Chin Yang, Shen, Li, Shin, Jean, Shumskaya, Elena, Sønderby, Ida E, Sprooten, Emma, Tansey, Katherine E, Teumer, Alexander, Thalamuthu, Anbupalam, Strike, Lachlan T, Tordesillas-Gutiérrez, Diana, Turner, Jessica A, Uhlmann, Anne, Vallerga, Costanza Ludovica, van der Meer, Dennis, van Donkelaar, Marjolein M J, van Eijk, Liza, van Erp, Theo G M, van Haren, Neeltje E M, van Rooij, Daan, Agartz, Ingrid, van Tol, Marie-José, Veldink, Jan H, Verhoef, Ellen, Walton, Esther, Wang, Mingyuan, Wang, Yunpeng, Wardlaw, Joanna M, Wen, Wei, Westlye, Lars T, Whelan, Christopher D, Alhusaini, Saud, Witt, Stephanie H, Wittfeld, Katharina, Wolf, Christiane, Wolfers, Thomas, Wu, Jing Qin, Yasuda, Clarissa L, Zaremba, Dario, Zhang, Zuo, Zwiers, Marcel P, Artiges, Eric, Almeida, Marcio A A, Assareh, Amelia A, Ayesa-Arriola, Rosa, Belger, Aysenil, Brandt, Christine L, Brown, Gregory G, Cichon, Sven, Curran, Joanne E, Davies, Gareth E, Degenhardt, Franziska, Dennis, Michelle F, Alnæs, Dag, Dietsche, Bruno, Djurovic, Srdjan, Doherty, Colin P, Espiritu, Ryan, Garijo, Daniel, Gil, Yolanda, Gowland, Penny A, Green, Robert C, Häusler, Alexander N, Heindel, Walter, Amlien, Inge K, Ho, Beng-Choon, Hoffmann, Wolfgang U, Holsboer, Florian, Homuth, Georg, Hosten, Norbert, Jack, Clifford R, Jang, MiHyun, Jansen, Andreas, Kimbrel, Nathan A, Kolskår, Knut, Painter, Jodie N, Andersson, Micael, Koops, Sanne, Krug, Axel, Lim, Kelvin O, Luykx, Jurjen J, Mathalon, Daniel H, Mather, Karen A, Mattay, Venkata S, Matthews, Sarah, Mayoral Van Son, Jaqueline, McEwen, Sarah C, Ard, Tyler, Melle, Ingrid, Morris, Derek W, Mueller, Bryon A, Nauck, Matthias, Nordvik, Jan E, Nöthen, Markus M, O'Leary, Daniel S, Opel, Nils, Martinot, Marie-Laure Paillère, Pike, G Bruce, Armstrong, Nicola J, Preda, Adrian, Quinlan, Erin B, Rasser, Paul E, Ratnakar, Varun, Reppermund, Simone, Steen, Vidar M, Tooney, Paul A, Torres, Fábio R, Veltman, Dick J, Voyvodic, James T, Ashley-Koch, Allison, Whelan, Robert, White, Tonya, Yamamori, Hidenaga, Adams, Hieab H H, Bis, Joshua C, Debette, Stephanie, Decarli, Charles, Fornage, Myriam, Gudnason, Vilmundur, Hofer, Edith, Atkins, Joshua R, Ikram, M Arfan, Launer, Lenore, Longstreth, W. T., Lopez, Oscar L, Mazoyer, Bernard, Mosley, Thomas H, Roshchupkin, Gennady V, Satizabal, Claudia L, Schmidt, Reinhold, Seshadri, Sudha, Bernard, Manon, Yang, Qiong, Initiative, Alzheimer’s Disease Neuroimaging, Consortium, CHARGE, Consortium, EPIGEN, Consortium, IMAGEN, Consortium, SYS, Initiative, Parkinson’s Progression Markers, Alvim, Marina K M, Ames, David, Anderson, Tim J, Brouwer, Rachel M, Andreassen, Ole A, Arias-Vasquez, Alejandro, Bastin, Mark E, Baune, Bernhard T, Beckham, Jean C, Blangero, John, Boomsma, Dorret I, Brodaty, Henry, Brunner, Han G, Buckner, Randy L, Buimer, Elizabeth E L, Buitelaar, Jan K, Bustillo, Juan R, Cahn, Wiepke, Cairns, Murray J, Calhoun, Vince, Carr, Vaughan J, Caseras, Xavier, Caspers, Svenja, Cavalleri, Gianpiero L, Cendes, Fernando, Bülow, Robin, Corvin, Aiden, Crespo-Facorro, Benedicto, Dalrymple-Alford, John C, Dannlowski, Udo, de Geus, Eco J C, Deary, Ian J, Delanty, Norman, Depondt, Chantal, Desrivières, Sylvane, Donohoe, Gary, Bürger, Christian, Espeseth, Thomas, Fernández, Guillén, Fisher, Simon E, Flor, Herta, Forstner, Andreas J, Francks, Clyde, Franke, Barbara, Glahn, David C, Gollub, Randy L, Grabe, Hans J, Colodro-Conde, Lucía, Cannon, Dara M, Gruber, Oliver, Håberg, Asta K, Hariri, Ahmad R, Hartman, Catharina A, Hashimoto, Ryota, Heinz, Andreas, Henskens, Frans A, Hillegers, Manon H J, Hoekstra, Pieter J, Holmes, Avram J, Chakravarty, Mallar, Hong, L Elliot, Hopkins, William D, Hulshoff Pol, Hilleke E, Jernigan, Terry L, Jönsson, Erik G, Kahn, René S, Kennedy, Martin A, Kircher, Tilo T J, Kochunov, Peter, Kwok, John B J, Chen, Qiang, Le Hellard, Stephanie, Loughland, Carmel M, Martin, Nicholas G, Martinot, Jean-Luc, McDonald, Colm, McMahon, Katie L, Meyer-Lindenberg, Andreas, Michie, Patricia T, Morey, Rajendra A, Mowry, Bryan, Cheung, Joshua W, Nyberg, Lars, Oosterlaan, Jaap, Ophoff, Roel A, Pantelis, Christos, Paus, Tomas, Pausova, Zdenka, Penninx, Brenda W J H, Polderman, Tinca J C, Posthuma, Danielle, 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Ana, de Zwarte, Sonja M C, Ulysse, Anaztasia, Uitterlinden, André G, Becker, Andreas, Budson, Andrew E, Kertesz, Andrew, Siderowf, Andrew, Bralten, Janita, den Braber, Anouk, Singleton, Andrew, James, Angela, Oliver, Angela, Mishra, Aniket, Hake, Ann Marie, Burke, Anna, Sarrael, Antero, Porsteinsson, Anton P, Stringaris, Argyris, McCoy, Arita, Doan, Nhat Trung, Villringer, Arno, Lenahan, Art, Toga, Arthur, Bokde, Arun, Rawlins, Ashlee, Lamb, Ashley, Lee, Athena, Raj, Balebail Ashok, Tran, Baochan, Dohm, Katharina, Ruggeri, Barbara, Saba, Barbara, Lane, Barton, Yanez, Beatriz, Ances, Beau, Dunlop, Becky, Mudge, Benita, Ravina, Bernard, Ittermann, Bernd, Ehrlich, Stefan, van Noort, Betteke, Lind, Betty, Shah, Bina, Stefanovic, Bojana, Goldstein, Bonnie S, Bonakdarpour, Borna, Matthews, Brandy R, Borowski, Bret, Ott, Brian R, Reynolds, Brigid, Engelbrecht, Hannah-Ruth, Mollenhauer, Brit, Miller, Bruce L, Psaty, Bruce M, Spann, Bryan M, Sadowsky, Carl, Linder, Carly, Franz, Carol E, Tanner, Caroline, Kopil, Catherine, Thomas, Cathi-Ann, Erk, Susanne, Ward, Chad, Bernick, Charles, Smith, Charles D, DeCarli, Charles, Caspell, Chelsea, Deeley, Cheryl, Riordan, Cheryl, Mathis, Chet, Onyike, Chiadi, Heyn, Chris Chinthaka, Fan, Chun Chieh, Hosein, Chris, Leach, Christi, Bÿchel, Christian, Gigliotti, Christina, Hunter, Christine, Belden, Christine M, Tzourio, Christophe, Coffey, Christopher, van Dyck, Christopher H, Clark, Christopher M, Fedko, Iryna O, Wu, Chuang-Kuo, Albers, Colleen S, Chu, Congying, Brand, Connie, Isensee, Corinna, van Duijn, Cornelia M, Bishop, Courtney, Bodge, Courtney, Foley, Sonya F, Tatsuoka, Curtis, Casaceli, Cynthia, Carlsson, Cynthia M, Mathews, Dana, D'Agostino, Daniel, Silverman, Daniel H S, Marson, Daniel, Berg, Daniela, Harvey, Danielle, Jennings, Danna, Ford, Judith M, Wolk, David A, Goldstein, David B, Bachman, David, Brooks, David, Clark, David, Geldmacher, David, Hart, David, Holtzman, David, Jones, David, Hibar, Derrek P, Fukunaga, Masaki, Knopman, David, Hewitt, David L, Perry, David, Russell, David, Standaert, David, Winkfield, David, Green, Davis Robert C, Fontaine, Deborah, Miller, Delwyn D, Gessert, Devon, Garrett, Melanie E, Kerwin, Diana, Willeke, Diana, Drost, Dick, Papadopoulos, Dimitri, Rowe, Dominic, Simpson, Donna M, Muni, Donna, Galasko, Douglas, Scharre, Douglas W, Fillmer, Ariane, Ge, Tian, Bartha, Rob, Celmins, Dzintra, Zimmerman, Earl A, Teng, Edmond, Tolosa, Eduardo, Coleman, Edward, Zamrini, Edward, Mitsis, Effie, Finger, Elizabeth, Giddaluru, Sudheer, Oates, Elizabeth, Sosa, Elizabeth, Woo, Ellen, Rogalski, Emily, Lethbridge, Emma, Dooley, Eoin, Foster, Eric, Reiman, Eric M, Quinlan, Erin Burke, Goldman, Aaron L, Franklin, Erin, Heinzen, Erin L, Fletcher, Evan, Sprenger, Fabienne, Crivello, Fabrice, Biondo, Francesca, Parfitt, Francine, Hefti, Franz, Beyer, Frauke, Nees, Frauke, Green, Melissa J, Leonard, Gabriel, Robert, Gabriel, Thai, Gaby, Marshall, Gad A, Barker, Gareth, Conrad, Gary, Tremont, Geoffrey, Bartzokis, George, Groenewold, Nynke A, Hsiung, Ging-Yuek Robin, Malferrari, Giulia, Chiang, Gloria, Pearlson, Godfrey D, Liang, Grace, Jicha, Greg, Sorensen, Greg, Todd, Gretchen, Jimenez, Gustavo, Grotegerd, Dominik, Zare, Habil, Grabe, Hans Jörgen, Vanderswag, Helen, Schmidt, Helena, Venkov, Heli, Lemaitre, Hervé, Gurholt, Tiril P, Grossman, Hillel, Shill, Holly, Soares, Holly, Lin, Honghuang, Capote, Horacio, Bergman, Howard, Chertkow, Howard, Feldman, Howard, Fillit, Howard, Rosen, Howard J, Gutman, Boris A, Koleva, Hristina, Fernandez, Hubert, Garavan, Hugh, Shim, Hyungsub, Grachev, Igor D, Richard, Irene, Filippi, Irina, Rachinsky, Irina, Wurster, Isabel, Lind, Penelope A, Hansell, Narelle K, Mintzer, Jacobo, Ziolkowski, Jaimie, Brewer, James, Lah, James J, Leverenz, James, Becker, James T, Tetrud, James, Singleton-Garvin, Jamika, Egebjerg, Jan, Cellar, Janet S, Harris, Mathew A, Pentilla, Jani, Brosch, Jared R, Tinklenberg, Jared, Karlawish, Jason H, Meyer, Javier Villanueva, Himali, Jayandra J, Poline, Jean-Baptiste, Gunter, Jeff, Kaye, Jeffrey A, Harrison, Marc B, Dalley, Jeffrey, Burns, Jeffrey M, Petrella, Jeffrey R, Mule, Jennifer, Salazar, Jennifer, Rotter, Jerome I, Yesavage, Jerome, Cedarbaum, Jesse, Jiang, Jiyang, Haswell, Courtney C, Allard, Joanne, Lord, Joanne L, Hetelle, Joel, Kwok, John B, Brockington, John, Morris, John C, Hsiao, John, Morris, John, Olichney, John, Trojanowki, John Q, Hauser, Michael, Rogers, John, Seibyl, John, Yankey, Jon, Dubow, Jordan S, Jankovic, Joseph, Quinn, Joseph, Kass, Joseph S, Taylor, Joy L, Heidebrink, Judith L, Herms, Stefan, Trollor, Julian, Fröhner, Juliane, Anderson, Karen, Blank, Karen, Crawford, Karen, Smith, Karen Ekstam, Bell, Karen L, Williams, Karen, Kieburtz, Karl, Heslenfeld, Dirk J, Gauss, Katharina, Gloer, Katherine, Johnson, Kathleen, Tingus, Kathleen, DeMarco, Kathryn, Sink, Kaycee M, Hawkins, Keith A, Johnson, Keith A, Kantarci, Kejal, Ho, New Fei, Faber, Kelley, Harless, Kelly, Makino, Kelly M, Marek, Kenneth, Spicer, Kenneth, Shianna, Kevin, Chen, Kewei, Nam, Ki Won, Martin, Kim, Poki-Walker, Kim, Hoehn, David, Seppi, Klaus, Johnson, Kris, Fargher, Kristin, Lipowski, Kristine, Espay, Kristy, Womack, Kyle, Chahine, Lama, Flashman, Laura A, Daedelow, Laura, Hoffmann, Per, Leary, Laura, Beckett, Laurel, Honig, Lawrence S, Thal, Leon, Shaw, Leslie M, Kuller, Lew, Apostolova, Liana, Teodoro, Liberty, Rees, Linda, Pizzagalli, Fabrizio, Holleran, Laurena, Lewis, Lindsay, Hergesheimer, Lindsey, Silbert, Lisa C, Ravdin, Lisa, Taylor-Reinwald, Lisa, Uribe, Liz, Schneider, Lon S, Daiello, Lori A, Richer, Louis, Poustka, Luise, Hoogman, Martine, Pirpamer, Lukas, Mesulam, M Marcel, Ismail, M Saleem, Ranola, Madelaine, Korecka, Magdalena, Raichle, Marc, Seltzer, Marc, van der Brug, Marcel, Hottenga, Jouke-Jan, Mesulam, Marek-Marsel, Carrillo, Maria, Carroll, Maria, Knol, Maria J, Kataki, Maria, Greig-Custo, Maria T, Paillere, Marie-Laure, Albert, Marilyn, Love, Marissa Natelson, Ikeda, Masashi, Mintun, Mark A, Frasier, Mark, Logue, Mark, Minton, Mark, Loeffler, Markus, Scholz, Markus, Baca, Marne, Farlow, Martin R, Sadowski, Martin, Janowitz, Deborah, Creech, Mary L, Hynes, Mary L, Quiceno, Mary, Oakley, MaryAnn, Harris, Mat, Senjem, Matt, Bernstein, Matthew, Panizzon, Matthew S, Stern, Matthew, Becerra, Mauricio, Jansen, Iris E, Witbracht, Megan, Vernooij, Meike W, Brandabur, Melanie, Keltz, Melanie, Lamar, Melissa, Yang, Mia, Ahlijanian, Michael, Borrie, Michael, Neale, Michael C, Donohue, Michael, Jia, Tianye, Lyons, Michael J, Lin, Michael, Rapp, Michael, Smolka, Michael, Weiner, Michael W, Weiner, Michael, Figurski, Michal, Perron, Michel, Assaly, Michele, Luciano, Michelle, Jockwitz, Christiane, Rainka, Michelle, Dang, Mimi, Sheikh, Mohammed O, Ghanbari, Mohsen, Gaikwad, Mrunalini, Chowdhury, Munir, Trncic, Nadira, Amin, Najaf, Johnson, Nancy, Kanai, Ryota, Kowalksi, Nancy, Monahan, Nancy, Gillespie, Nathan A, Pacini, Nathaniel, Buckholtz, Neil, Kowall, Neil, Graff-Radford, Neill R, Fox, Nick, Pavese, Nicola, Karama, Sherif, Cairns, Nigel J, Schuff, Norbert, Foster, Norm, Relkin, Norman, Oyonumo, Ntekim E, Pomara, Nunzio, James, Olga, Ogunlana, Olu, Ching, Christopher R K, Kasperaviciute, Dalia, Carmichael, Owen, Doraiswamy, P Murali, Casalin, Paola, Barone, Paolo, Fatica, Parianne, Conrod, Patricia, Johnson, Patricia Lynn, Samuels, Patricia, Aisen, Paul, Malloy, Paul, Kaufmann, Tobias, Thompson, Paul, Ogrocki, Paula, Bezivin-Frere, Pauline, Maillard, Pauline, Fontoura, Paulo, Taylor, Peggy, Hogarth, Penelope, Gowland, Penny, Davies, Peter, Kelly, Sinead, Hardy, Peter, Snyder, Peter J, Snyder, Peter, Amouyel, Philippe, Muglia, Pierandrea, Tariot, Pierre, Lu, Po H, Varma, Pradeep, Vemuri, Prashanthi, Kikuchi, Masataka, Doody, Rachelle S, Carter, Raina, Shah, Raj C, Griffith, Randall, Yeh, Randy, Duara, Ranjan, Tarawneh, Rawan, James, Raymond, Turner, Raymond Scott, Klein, Marieke, Hernando, Raymundo, Silverstein, Rebecca, Sperling, Reisa A, Wilson, Renee, Carson, Richard E, Frank, Richard, El Khouli, Riham, Koeppe, Robert A, Santulli, Robert B, Knapp, Michael, Hauser, Robert, Umek, Robert, Radtke, Rodney, Killiany, Ronald, Petersen, Ronald, Rodriguez, Rosemarie, Miranda, Ruben, Knodt, Annchen R, Bruehl, Ruediger, Xia, Rui, Swerdlow, Russell H, Ottmann, Ruth, Millenet, Sabina, Borges-Neto, Salvador, Frank, Samuel, Black, Sandra, Weintraub, Sandra, Obradov, Sanja, Krämer, Bernd, Asthana, Sanjay, Vaishnavi, Sanjeev, Dolen, Sara, Mason, Sara S, Hohmann, Sarah, Kremen, Sarah, Miller, Sarah, Walter, Sarah, Herring, Scott, Neu, Scott, Lam, Max, Aydin, Semiha, Ahmad, Shahzad, Harlan, Sherry, Sirrel, Sherye A, Lasch, Shirley, Hu, Shu-Ching, Li, Shuo, Kittur, Smita, Chowdhury, Sohini, Lancaster, Thomas M, Pawluczyk, Sonia, Maingault, Sophie, Schneider, Stacy, Seiler, Stephan, Guthrie, Stephanie, Kielb, Stephanie, Reeder, Stephanie, Correia, Stephen, Pasternak, Stephen, McMahon, Mary Agnes B, Lee, Phil H, Salloway, Stephen, Johnson, Sterling, Williams, Steve, Chao, Steven, Arnold, Steven E, Paul, Steven, Potkin, Steven, Factor, Stewart, Isaacson, Stuart, Lett, Tristram A, Kim, Sungeun, Ainscough, Susan, Schultz, Susan K, Landau, Susan, Mendick, Susan, Rountree, Susan, Ostrowizki, Suzanne, Veillette, Suzanne, van der Lee, Sven J, Desrivieres, Sylvane, Lewis, Lindsay B, Lee, T-Y, Simuni, Tanya, Foroud, Tatiana, Foroud, Tatiana M, Wong, Terence Z, Villena, Teresa, Comery, Thomas, Obisesan, Thomas O, Lopes-Cendes, Iscia, Banaschewski, Tobias, Sherer, Todd, Montine, Tom, Paus, Tomáš, Robbins, Trevor, Bromberg, Uli, Völker, Uwe, Pavlik, Valory, Arnedo, Vanessa, Kiyasova, Vera, Bates, Vernice, Logovinsky, Veronika, Sossi, Vesna, Shibley, Victoria, Frouin, Vincent, Lee, Virginia, Poewe, Werner, Jagust, William, Brooks, William M, Macciardi, Fabio, Pavlosky, William, Potter, William, Kremen, William S, Longstreth, William T, Niessen, Wiro J, Jian, Xueqiu, Stern, Yaakov, Saba, Yasaman, Cabrera, Yuliana, Grimmer, Yvonne, Marquand, Andre F, Khachaturian, Zaven, Mari, Zoltan, Mathias, Samuel R, Melzer, Tracy R, Milaneschi, Yuri, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Movement Disorder (MD), Alzheimer’s Disease Neuroimaging Initiative, CHARGE Consortium, EPIGEN Consortium, IMAGEN Consortium, SYS Consortium, Parkinson’s Progression Markers Initiative, Stochastics, Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Mental Health, Science and Society, Cognitive Psychology, IBBA, APH - Personalized Medicine, Complex Trait Genetics, APH - Methodology, Clinical Neuropsychology, Sociology and Social Gerontology, Amsterdam Neuroscience - Complex Trait Genetics, RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, Klinische Genetica, RS: GROW - R4 - Reproductive and Perinatal Medicine, MUMC+: DA Klinische Genetica (5), Neurology, Psychiatry, Pediatric surgery, Amsterdam Reproduction & Development (AR&D), Human genetics, APH - Digital Health, Psychology, Precision Medicine Institute of Psychiatry, Child and Adolescent Psychiatry / Psychology, Radiology & Nuclear Medicine, Clinical Genetics, Epidemiology, Medical Informatics, Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Neurodegeneratives Diseases Institute (IMN-UMR CNRS 5293), Centre National de la Recherche Scientifique (CNRS), General Paediatrics, ARD - Amsterdam Reproduction and Development, Direction de Recherche Fondamentale (CEA) (DRF (CEA)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay
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0301 basic medicine ,Netherlands Twin Register (NTR) ,[SDV]Life Sciences [q-bio] ,LOCI ,Genome-wide association study ,Brain mapping ,0302 clinical medicine ,Cognition ,Cortex (anatomy) ,ComputingMilieux_MISCELLANEOUS ,Cerebral Cortex ,0303 health sciences ,Brain Mapping ,Multidisciplinary ,COMMON VARIANTS ,Parkinson Disease ,Organ Size ,Central sulcus ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Cerebral cortex ,Neuroinformatics ,EXPRESSION ,endocrine system ,central sulcus ,SURFACE-AREA ,Biology ,Article ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,Genetic variation ,medicine ,Attention deficit hyperactivity disorder ,Humans ,General ,Gene ,METAANALYSIS ,030304 developmental biology ,Progenitor ,CORTICAL SULCI ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,Genetic variants ,Genetic Variation ,Attention Deficit Disorder with Hyperactivity ,Genetic Loci ,Genome-Wide Association Study ,functional annotation ,medicine.disease ,Genetic architecture ,030104 developmental biology ,Evolutionary biology ,OBSERVER-INDEPENDENT CHARACTERIZATION ,Multiple comparisons problem ,ddc:320 ,genome-wide association ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)—Genetics working group., The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.
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- 2020
22. Neural Correlates of Adolescent Irritability and Its Comorbidity With Psychiatric Disorders
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Chaarani, Bader, primary, Kan, Kees-Jan, additional, Mackey, Scott, additional, Spechler, Philip A., additional, Potter, Alexandra, additional, Banaschewski, Tobias, additional, Millenet, Sabina, additional, Bokde, Arun L.W., additional, Bromberg, Uli, additional, Büchel, Christian, additional, Cattrell, Anna, additional, Conrod, Patricia J., additional, Desrivières, Sylvane, additional, Flor, Herta, additional, Frouin, Vincent, additional, Gallinat, Jürgen, additional, Gowland, Penny, additional, Heinz, Andreas, additional, Ittermann, Bernd, additional, Martinot, Jean-Luc, additional, Nees, Frauke, additional, Paus, Tomáš, additional, Poustka, Luise, additional, Smolka, Michael N., additional, Walter, Henrik, additional, Whelan, Robert, additional, Stringaris, Argyris, additional, Higgins, Stephen T., additional, Schumann, Gunter, additional, Garavan, Hugh, additional, Althoff, Robert R., additional, Rapp, Dr. Michael, additional, Artiges, Dr. Eric, additional, Schneider, Sophia, additional, Bach, Christine, additional, Paus, Dr. Tomas, additional, Barbot, Alexis, additional, Barker, Dr. Gareth, additional, Bokde, Dr. Arun, additional, Vetter, Dr. Nora, additional, Büchel, Dr. Christian, additional, Cattrell, Dr. Anna, additional, Constant, Patrick, additional, Crombag, Dr. Hans, additional, Czech, Katharina, additional, Dalley, Dr. Jeffrey, additional, Decideur, Benjamin, additional, Spranger, Tade, additional, Ripley, Dr. Tamzin, additional, Heym, Dr. Nadja, additional, Sommer, Dr. Wolfgang, additional, Fuchs, Birgit, additional, Gallinat, Dr. Jürgen, additional, Garavan, Dr. Hugh, additional, Spanagel, Dr. Rainer, additional, Kaviani, Mehri, additional, Heinrichs, Dr. Bert, additional, Heinz, Dr. Andreas, additional, Subramaniam, Naresh, additional, Jia, Dr. Tianye, additional, Ihlenfeld, Albrecht, additional, Ireland, James, additional, Ittermann, Dr. Bernd, additional, Conrod, Dr. Patricia, additional, Banaschewski, Dr. Tobias, additional, Jones, Jennifer, additional, Klaassen, Dr. Arno, additional, Lalanne, Christophe, additional, Lanzerath, Dr. Dirk, additional, Lawrence, Dr. Claire, additional, Lemaitre, Dr. Hervé, additional, Desrivieres, Dr. Sylvane, additional, Mallik, Catherine, additional, Mann, Dr. Karl, additional, Mar, Dr. Adam, additional, Martinez-Medina, Lourdes, additional, Martinot, Dr. Jean-Luc, additional, Mennigen, Eva, additional, Mesquita de Carvahlo, Dr. Fabiana, additional, Schwartz, Yannick, additional, Bruehl, Dr. Ruediger, additional, Müller, Kathrin, additional, Nymberg, Charlotte, additional, Lathrop, Dr. Mark, additional, Robbins, Dr. Trevor, additional, Pausova, Dr. Zdenka, additional, Pentilla, Dr. Jani, additional, Biondo, Dr. Francesca, additional, Poline, Dr. Jean-Baptiste, additional, Poustka, Dr. Luise, additional, Smolka, Dr. Michael, additional, Fröhner, Juliane, additional, Struve, Dr. Maren, additional, Williams, Dr. Steve, additional, Hübner, Dr. Thomas, additional, Aydin, Semiha, additional, Rogers, John, additional, Romanowski, Alexander, additional, Schmäl, Dr. Christine, additional, Schmidt, Dirk, additional, Ripke, Stephan, additional, Arroyo, Dr. Mercedes, additional, Schubert, Dr. Florian, additional, Pena-Oliver, Dr. Yolanda, additional, Fauth-Bühler, Mira, additional, Mignon, Xavier, additional, Whelan, Dr. Robert, additional, Speiser, Dr. Claudia, additional, Fadai, Tahmine, additional, Stephens, Dr. Dai, additional, Ströhle, Dr. Andreas, additional, Paillere, Dr. Marie-Laure, additional, Strache, Nicole, additional, Theobald, David, additional, Jurk, Sarah, additional, Vulser, Dr. Helene, additional, Miranda, Ruben, additional, Yacubilin, Dr. Juliana, additional, Genauck, Alexander, additional, Parchetka, Caroline, additional, Gemmeke, Isabel, additional, Kruschwitz, Johann, additional, Weiss, Katharina, additional, Walter, Dr. Henrik, additional, Feng, Jianfeng, additional, Papadopoulos, Dimitri, additional, Filippi, Irina, additional, Ing, Alex, additional, Ruggeri, Dr. Barbara, additional, Xu, Bing, additional, Macare, Christine, additional, Chu, Dr. Congying, additional, Hanratty, Eanna, additional, Burke Quinlan, Dr. Erin, additional, Robert, Dr. Gabriel, additional, Schumann, Dr. Gunter, additional, Yu, Dr. Tao, additional, Ziesch, Veronika, additional, and Stedman, Alicia, additional
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- 2020
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23. Dopamine D2/3 receptor availability in alcohol use disorder and individuals at high risk: Towards a dimensional approach
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Gleich, Tobias, primary, Spitta, Gianna, additional, Butler, Oisin, additional, Zacharias, Kristin, additional, Aydin, Semiha, additional, Sebold, Miriam, additional, Garbusow, Maria, additional, Rapp, Michael, additional, Schubert, Florian, additional, Buchert, Ralph, additional, Heinz, Andreas, additional, and Gallinat, Juergen, additional
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- 2020
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24. Cannabis-Associated Psychotic-like Experiences Are Mediated by Developmental Changes in the Parahippocampal Gyrus
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Yu, Tao, primary, Jia, Tianye, additional, Zhu, Liping, additional, Desrivières, Sylvane, additional, Macare, Christine, additional, Bi, Yan, additional, Bokde, Arun L.W., additional, Quinlan, Erin Burke, additional, Heinz, Andreas, additional, Ittermann, Bernd, additional, Liu, ChuanXin, additional, Ji, Lei, additional, Banaschewski, Tobias, additional, Ren, Decheng, additional, Du, Li, additional, Hou, Binyin, additional, Flor, Herta, additional, Frouin, Vincent, additional, Garavan, Hugh, additional, Gowland, Penny, additional, Martinot, Jean-Luc, additional, Paillère Martinot, Marie-Laure, additional, Nees, Frauke, additional, Orfanos, Dimitri Papadopoulos, additional, Luo, Qiang, additional, Chu, Congying, additional, Paus, Tomas, additional, Poustka, Luise, additional, Hohmann, Sarah, additional, Millenet, Sabina, additional, Smolka, Michael N., additional, Vetter, Nora C., additional, Mennigen, Eva, additional, Lei, Cai, additional, Walter, Henrik, additional, Fröhner, Juliane H., additional, Whelan, Robert, additional, He, Guang, additional, He, Lin, additional, Schumann, Gunter, additional, Robert, Gabriel, additional, Rapp, Michael, additional, Artiges, Eric, additional, Schneider, Sophia, additional, Bach, Christine, additional, Barbot, Alexis, additional, Barker, Gareth, additional, Bokde, Arun, additional, Vetter, Nora, additional, Büchel, Christian, additional, Cattrell, Anna, additional, Constant, Patrick, additional, Crombag, Hans, additional, Czech, Katharina, additional, Dalley, Jeffrey, additional, Decideur, Benjamin, additional, Spranger, Tade, additional, Ripley, Tamzin, additional, Heym, Nadja, additional, Sommer, Wolfgang, additional, Fuchs, Birgit, additional, Gallinat, Jürgen, additional, Spanagel, Rainer, additional, Kaviani, Mehri, additional, Heinrichs, Bert, additional, Subramaniam, Naresh, additional, Ihlenfeld, Albrecht, additional, Delosis, James Ireland, additional, Conrod, Patricia, additional, Jones, Jennifer, additional, Klaassen, Arno, additional, Lalanne, Christophe, additional, Lanzerath, Dirk, additional, Lawrence, Claire, additional, Lemaitre, Hervé, additional, Desrivieres, Sylvane, additional, Mallik, Catherine, additional, Mann, Karl, additional, Mar, Adam, additional, Martinez-Medina, Lourdes, additional, de Carvahlo, Fabiana Mesquita, additional, Schwartz, Yannick, additional, Bruehl, Ruediger, additional, Müller, Kathrin, additional, Nymberg, Charlotte, additional, Lathrop, Mark, additional, Robbins, Trevor, additional, Pausova, Zdenka, additional, Pentilla, Jani, additional, Biondo, Francesca, additional, Poline, Jean-Baptiste, additional, Smolka, Michael, additional, Fröhner, Juliane, additional, Struve, Maren, additional, Williams, Steve, additional, Hübner, Thomas, additional, Bromberg, Uli, additional, Aydin, Semiha, additional, Rogers, John, additional, Romanowski, Alexander, additional, Schmäl, Christine, additional, Schmidt, Dirk, additional, Ripke, Stephan, additional, Arroyo, Mercedes, additional, Schubert, Florian, additional, Pena-Oliver, Yolanda, additional, Fauth-Bühler, Mira, additional, Mignon, Xavier, additional, Speiser, Claudia, additional, Fadai, Tahmine, additional, Stephens, Dai, additional, Ströhle, Andreas, additional, Paillere, Marie-Laure, additional, Strache, Nicole, additional, Theobald, David, additional, Jurk, Sarah, additional, Vulser, Helene, additional, Miranda, Ruben, additional, Yacubilin, Juliana, additional, Genauck, Alexander, additional, Parchetka, Caroline, additional, Gemmeke, Isabel, additional, Kruschwitz, Johann, additional, WeiB, Katharina, additional, Feng, Jianfeng, additional, Papadopoulos, Dimitri, additional, Filippi, Irina, additional, Ing, Alex, additional, Ruggeri, Barbara, additional, Xu, Bing, additional, Hanratty, Eanna, additional, Yu, Tao, additional, Ziesch, Veronika, additional, and Stedman, Alicia, additional
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- 2020
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25. Recognition of anxiety disorders in children: a cross-sectional vignette-based survey among general practitioners
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Aydin, Semiha, primary, Crone, Mathilde R, additional, Siebelink, Bart M, additional, Vermeiren, Robert R J M, additional, Numans, Mattijs E, additional, and Westenberg, P Michiel, additional
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- 2020
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26. Towards precise brain stimulation:Is electric field simulation related to neuromodulation?
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Antonenko, Daria, Thielscher, Axel, Saturnino, Guilherme Bicalho, Aydin, Semiha, Ittermann, Bernd, Grittner, Ulrike, Flöel, Agnes, Antonenko, Daria, Thielscher, Axel, Saturnino, Guilherme Bicalho, Aydin, Semiha, Ittermann, Bernd, Grittner, Ulrike, and Flöel, Agnes
- Abstract
Background: Recent research on neural and behavioral consequences of transcranial direct current stimulation (tDCS) has highlighted the impact of individual factors, such as brain anatomy which determines current field distribution and may thus significantly impact stimulation effects. Computational modeling approaches may significantly advance our understanding of such factors, but the association of simulation-based tDCS-induced fields and neurophysiological outcomes has not been investigated. Objectives: To provide empirical evidence for the relationship between tDCS-induced neurophysiological outcomes and individually induced electric fields. Methods: We applied tDCS during eyes-closed resting-state functional resonance imaging (rsfMRI) and assessed pre-post magnetic resonance spectroscopy (MRS) in 24 participants. We aimed to quantify effects of 15-min tDCS using the “classical” left SM1-right supraorbital area montage on sensorimotor network (SMN) strength and gamma-aminobutyric acid (GABA) and glutamate concentrations, implementing a cross-over counterbalanced design with three stimulation conditions. Additional structural anatomical MRI sequences and recordings of individual electrode configurations allowed individual electric field simulations based on realistic head models of all participants for both conditions. Results: On a neurophysiological level, we observed the expected reduction of GABA concentrations and increase in SMN strength, both during anodal and cathodal compared to sham tDCS, replicating previous results. The magnitudes of neurophysiological modulations induced by tDCS were significantly associated with simulation-based electric field strengths within the targeted left precentral gyrus. Conclusion: Our findings corroborate previous reports on tDCS-induced neurophysiological modulations and further advance the understanding of underlying mechanisms by providing first empirical evidence for the association of the injected electric field a
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- 2019
27. Kadın Akademisyenlerin Giysi Alışverişlerinde E- Ticareti Tercih Etme Nedenleri
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AYDIN, SEMİHA
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Günümüzde teknolojik alandaki hızlı değişimler ve internetin yaygınlaşarak hayatlarımıza girmesiyle birlikte birçok sektörde olduğu gibi alışveriş sektöründe de değişimler gözlenmiştir. Bu değişimler ile tüketiciler evden çıkmadan dünyadaki tüm alışveriş merkezlerinden alışveriş yapabilme imkanına kavuşmuşlardır. Gün geçtikçe artan sayıda insan internetten alışveriş yapmayı tercih etmeye başlamıştır. İnternet üzerinden yapılan alışveriş yoğun gündelik hayatta tüketicinin zamanını verimli kullanmasını sağlamaktadır. Bu araştırma, 22- 49 yaş arası kadın akademisyenlerin online giysi alışverişi yaparken karşılaştıkları sorunları ve bu sorunlar karşısında takındıkları tutumları araştırmak amacı ile yapılmıştır. Araştırmanın evrenini Ankara ilinde görev yapan kadın akademisyenler oluştururken örneklemini 22- 49 yaş arası 300 kadın akademisyen oluşturmaktadır. Araştırmada veri toplama aracı olarak anket yöntemi kullanılmış ve anket verilerinin analizi IBM SPSS Statics Version 24 paket programında yapılmıştır. Ölçeğin tümüne ait Cronbachzs Alfa güvenilirlik katsayıları hesaplanmış ve verilerin gruplar arasında karşılaştırılmasında Pearson Chi-Square, Fisherzs Exact test ve Ki-kare trend istatistiksel analizleri kullanılarak p
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- 2018
28. Towards precise brain stimulation: Is electric field simulation related to neuromodulation?
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Antonenko, Daria, primary, Thielscher, Axel, additional, Saturnino, Guilherme Bicalho, additional, Aydin, Semiha, additional, Ittermann, Bernd, additional, Grittner, Ulrike, additional, and Flöel, Agnes, additional
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- 2019
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29. P3-400: MYOINOSITOL CONCENTRATION AND VOLUME OF THE POSTERIOR CINGULATE CORTEX ACROSS THE AD CONTINUUM MEASURED BY 7T MRI/MRS
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Göschel, Laura, primary, Köbe, Theresa, additional, Wang, Hui, additional, Aydin, Semiha, additional, Ittermann, Bernd, additional, Fillmer, Ariane, additional, and Flöel, Agnes, additional
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- 2019
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30. Dopamine D2/3 receptor availability in alcohol use disorder and individuals at high risk: Towards a dimensional approach.
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Gleich, Tobias, Spitta, Gianna, Butler, Oisin, Zacharias, Kristin, Aydin, Semiha, Sebold, Miriam, Garbusow, Maria, Rapp, Michael, Schubert, Florian, Buchert, Ralph, Heinz, Andreas, and Gallinat, Juergen
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ALCOHOLISM ,DOPAMINE receptors ,ALCOHOL Dependence Scale ,SUBSTANCE abuse ,POSITRON emission tomography ,IMPULSE control disorders ,BASAL ganglia ,CLASSIFICATION ,CELL receptors ,PATIENTS ,RESEARCH funding ,EMISSION-computed tomography ,COMPULSIVE behavior - Abstract
Alcohol use disorder (AUD) is the most common substance use disorder worldwide. Although dopamine-related findings were often observed in AUD, associated neurobiological mechanisms are still poorly understood. Therefore, in the present study, we investigate D2/3 receptor availability in healthy participants, participants at high risk (HR) to develop addiction (not diagnosed with AUD), and AUD patients in a detoxified stage, applying 18 F-fallypride positron emission tomography (18 F-PET). Specifically, D2/3 receptor availability was investigated in (1) 19 low-risk (LR) controls, (2) 19 HR participants, and (3) 20 AUD patients after alcohol detoxification. Quality and severity of addiction were assessed with clinical questionnaires and (neuro)psychological tests. PET data were corrected for age of participants and smoking status. In the dorsal striatum, we observed significant reductions of D2/3 receptor availability in AUD patients compared with LR participants. Further, receptor availability in HR participants was observed to be intermediate between LR and AUD groups (linearly decreasing). Still, in direct comparison, no group difference was observed between LR and HR groups or between HR and AUD groups. Further, the score of the Alcohol Dependence Scale (ADS) was inversely correlated with D2/3 receptor availability in the combined sample. Thus, in line with a dimensional approach, striatal D2/3 receptor availability showed a linear decrease from LR participants to HR participants to AUD patients, which was paralleled by clinical measures. Our study shows that a core neurobiological feature in AUD seems to be detectable in an early, subclinical state, allowing more individualized alcohol prevention programs in the future. [ABSTRACT FROM AUTHOR]
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- 2021
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31. P3‐356: NEGATIVE RELATIONSHIP BETWEEN DECLARATIVE MEMORY PERFORMANCE AND HIPPOCAMPAL VOLUME EXTRACTED FROM 7 TESLA MR IMAGES OF HEALTHY OLDER ADULTS
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Göschel, Laura, primary, Köbe, Theresa, additional, Wang, Hui, additional, Fillmer, Ariane, additional, Aydin, Semiha, additional, and Flöel, Agnes, additional
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- 2018
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32. P3‐442: CEREBRAL GABA, RESTING‐STATE FUNCTIONAL CONNECTIVITY AND MEMORY FUNCTION IN ALZHEIMER'S DISEASE
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Köbe, Theresa, primary, Wang, Hui, additional, Göschel, Laura, additional, Aydin, Semiha, additional, Ittermann, Bernd, additional, Flöel, Agnes, additional, and Fillmer, Ariane, additional
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- 2018
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33. Evaluation of Vitamin E, Selenium and Glutathione Peroxidase Activity in Patients with Disseminated Intravascular Coagulation
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AKYILDIZ, Başak Nur, primary, KARAKÜKÇÜ, Musa, additional, KENDİRCİ, Mustafa, additional, MUHTAROĞLU, Sabahattin, additional, AYDIN, Semiha, additional, YILMAZ, İbrahim, additional, and ÖZSOYLU, Serkan, additional
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- 2017
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34. tDCS-Induced Modulation of GABA Levels and Resting-State Functional Connectivity in Older Adults
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Antonenko, Daria, primary, Schubert, Florian, additional, Bohm, Florian, additional, Ittermann, Bernd, additional, Aydin, Semiha, additional, Hayek, Dayana, additional, Grittner, Ulrike, additional, and Flöel, Agnes, additional
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- 2017
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35. Detection of metabolite changes in response to a varying visual stimulation paradigm using short-TE 1 H MRS at 7 T
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Mekle, Ralf, primary, Kühn, Simone, additional, Pfeiffer, Harald, additional, Aydin, Semiha, additional, Schubert, Florian, additional, and Ittermann, Bernd, additional
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- 2016
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36. Common genetic variants influence human subcortical brain structures
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Hibar, Derrek P, Stein, Jason L, Aribisala, Benjamin S, de Zubicaray, Greig I, Dillman, Allissa, Duggirala, Ravi, Dyer, Thomas D, Erk, Susanne, Fedko, Iryna O, Ferrucci, Luigi, Foroud, Tatiana M, Fox, Peter T, Fukunaga, Masaki, Armstrong, Nicola J, Gibbs, J Raphael, Göring, Harald H H, Green, Robert C, Guelfi, Sebastian, Hansell, Narelle K, Hartman, Catharina A, Hegenscheid, Katrin, Heinz, Andreas, Hernandez, Dena G, Heslenfeld, Dirk J, Bernard, Manon, Hoekstra, Pieter J, Holsboer, Florian, Homuth, Georg, Hottenga, Jouke-Jan, Ikeda, Masashi, Jack, Clifford R, Jenkinson, Mark, Johnson, Robert, Kanai, Ryota, Keil, Maria, Bohlken, Marc M, Kent, Jack W, Kochunov, Peter, Kwok, John B, Lawrie, Stephen M, Liu, Xinmin, Longo, Dan L, McMahon, Katie L, Meisenzahl, Eva, Melle, Ingrid, Mohnke, Sebastian, Boks, Marco P, Montgomery, Grant W, Mostert, Jeanette C, Mühleisen, Thomas W, Nalls, Michael A, Nichols, Thomas E, Nilsson, Lars G, Nöthen, Markus M, Ohi, Kazutaka, Olvera, Rene L, Perez-Iglesias, Rocio, Bralten, Janita, Pike, G Bruce, Potkin, Steven G, Reinvang, Ivar, Reppermund, Simone, Rietschel, Marcella, Romanczuk-Seiferth, Nina, Rosen, Glenn D, Rujescu, Dan, Schnell, Knut, Schofield, Peter R, Brown, Andrew A, Smith, Colin, Steen, Vidar M, Sussmann, Jessika E, Thalamuthu, Anbupalam, Toga, Arthur W, Traynor, Bryan J, Troncoso, Juan, Turner, Jessica A, Valdés Hernández, Maria C, van 't Ent, Dennis, Chakravarty, M Mallar, van der Brug, Marcel, van der Wee, Nic J A, van Tol, Marie-Jose, Veltman, Dick J, Wassink, Thomas H, Westman, Eric, Zielke, Ronald H, Zonderman, Alan B, Ashbrook, David G, Hager, Reinmar, Chen, Qiang, Lu, Lu, McMahon, Francis J, Morris, Derek W, Williams, Robert W, Brunner, Han G, Buckner, Randy L, Buitelaar, Jan K, Cahn, Wiepke, Calhoun, Vince D, Cavalleri, Gianpiero L, Ching, Christopher R K, Crespo-Facorro, Benedicto, Dale, Anders M, Davies, Gareth E, Delanty, Norman, Depondt, Chantal, Djurovic, Srdjan, Drevets, Wayne C, Espeseth, Thomas, Gollub, Randy L, Ho, Beng-Choon, Renteria, Miguel E, Cuellar-Partida, Gabriel, Hoffmann, Wolfgang, Hosten, Norbert, Kahn, René S, Le Hellard, Stephanie, Meyer-Lindenberg, Andreas, Müller-Myhsok, Bertram, Nauck, Matthias, Nyberg, Lars, Pandolfo, Massimo, Penninx, Brenda W J H, den Braber, Anouk, Roffman, Joshua L, Sisodiya, Sanjay M, Smoller, Jordan W, van Bokhoven, Hans, van Haren, Neeltje E M, Völzke, Henry, Walter, Henrik, Weiner, Michael W, Wen, Wei, White, Tonya, Giddaluru, Sudheer, Agartz, Ingrid, Andreassen, Ole A, Blangero, John, Boomsma, Dorret I, Brouwer, Rachel M, Cannon, Dara M, Cookson, Mark R, de Geus, Eco J C, Deary, Ian J, Donohoe, Gary, Goldman, Aaron L, Fernández, Guillén, Fisher, Simon E, Francks, Clyde, Glahn, David C, Grabe, Hans J, Gruber, Oliver, Hardy, John, Hashimoto, Ryota, Hulshoff Pol, Hilleke E, Jönsson, Erik G, Grimm, Oliver, Kloszewska, Iwona, Lovestone, Simon, Mattay, Venkata S, Mecocci, Patrizia, McDonald, Colm, McIntosh, Andrew M, Ophoff, Roel A, Paus, Tomas, Pausova, Zdenka, Ryten, Mina, Guadalupe, Tulio, Sachdev, Perminder S, Saykin, Andrew J, Simmons, Andy, Singleton, Andrew, Soininen, Hilkka, Wardlaw, Joanna M, Weale, Michael E, Weinberger, Daniel R, Adams, Hieab H H, Launer, Lenore J, Hass, Johanna, Seiler, Stephan, Schmidt, Reinhold, Chauhan, Ganesh, Satizabal, Claudia L, Becker, James T, Yanek, Lisa, van der Lee, Sven J, Ebling, Maritza, Fischl, Bruce, Longstreth, W. T., Woldehawariat, Girma, Greve, Douglas, Schmidt, Helena, Nyquist, Paul, Vinke, Louis N, van Duijn, Cornelia M, Xue, Luting, Mazoyer, Bernard, Bis, Joshua C, Gudnason, Vilmundur, Seshadri, Sudha, Holmes, Avram J, Ikram, M Arfan, Initiative, Alzheimer’s Disease Neuroimaging, Consortium, CHARGE, EPIGEN, IMAGEN, SYS, Martin, Nicholas G, Wright, Margaret J, Schumann, Gunter, Franke, Barbara, Hoogman, Martine, Thompson, Paul M, Medland, Sarah E, Weiner, Michael, Aisen, Paul, Petersen, Ronald, Jagust, William, Trojanowki, John Q, Beckett, Laurel, Arias-Vasquez, Alejandro, Janowitz, Deborah, Morris, John, Shaw, Leslie M, Khachaturian, Zaven, Sorensen, Greg, Carrillo, Maria, Kuller, Lew, Raichle, Marc, Paul, Steven, Jia, Tianye, Davies, Peter, Fillit, Howard, Hefti, Franz, Holtzman, Davie, Mesulman, M Marcel, Potter, William, Snyder, Peter, Schwartz, Adam, Montine, Tom, Kim, Sungeun, Thomas, Ronald G, Donohue, Michael, Walter, Sarah, Gessert, Devon, Sather, Tamie, Jiminez, Gus, Harvey, Danielle, Klein, Marieke, Bernstein, Matthew, Fox, Nick, Thompson, Paul, Schuff, Norbert, DeCarli, Charles, Borowski, Bret, Gunter, Jeff, Senjem, Matt, Kraemer, Bernd, Vemuri, Prashanthi, Jones, David, Kantarci, Kejal, Ward, Chad, Koeppe, Robert A, Foster, Norm, Reiman, Eric M, Chen, Kewei, Mathis, Chet, Lee, Phil H, Landau, Susan, Cairns, Nigel J, Householder, Erin, Taylor-Reinwald, Lisa, Trojanowki, J. Q., Shaw, Les, Lee, Virginia M Y, Korecka, Magdalena, Figurski, Michal, Olde Loohuis, Loes M, Crawford, Karen, Neu, Scott, Potkin, Steven, Shen, Li, Faber, Kelley, Nho, Kwangsik, Luciano, Michelle, Thal, Leon, Frank, Richard, Snyder, Peter J, Buckholtz, Neil, Macare, Christine, Albert, Marilyn, Hsiao, John, Kaye, Jeffrey, Quinn, Joseph, Lind, Betty, Carter, Raina, Dolen, Sara, Gutman, Boris A, Schneider, Lon S, Mather, Karen A, Pawluczyk, Sonia, Beccera, Mauricio, Teodoro, Liberty, Spann, Bryan M, Brewer, James, Vanderswag, Helen, Fleisher, Adam, Heidebrink, Judith L, Lord, Joanne L, Desrivières, Sylvane, Mattheisen, Manuel, Mason, Sara S, Albers, Colleen S, Knopman, David, Johnson, Kris, Doody, Rachelle S, Villanueva-Meyer, Javier, Chowdhury, Munir, Rountree, Susan, Dang, Mimi, Stern, Yaakov, Milaneschi, Yuri, Honig, Lawrence S, Bell, Karen L, Ances, Beau, Morris, John C, Carroll, Maria, Leon, Sue, Mintun, Mark A, Schneider, Stacy, Oliver, Angela, Marson, Daniel, Griffith, Randall, Clark, David, Geldmacher, David, Brockington, John, Roberson, Erik, Grossman, Hillel, Mitsis, Effie, deToledo-Morrell, Leyla, Shah, Raj C, Papmeyer, Martina, Duara, Ranjan, Varon, Daniel, Greig, Maria T, Roberts, Peggy, Onyike, Chiadi, D'Agostino, Daniel, Kielb, Stephanie, Galvin, James E, Pogorelec, Dana M, Ramasamy, Adaikalavan, Cerbone, Brittany, Michel, Christina A, Rusinek, Henry, de Leon, Mony J, Glodzik, Lidia, De Santi, Susan, Doraiswamy, P Murali, Petrella, Jeffrey R, Wong, Terence Z, Arnold, Steven E, Risacher, Shannon L, Karlawish, Jason H, Wolk, David, Smith, Charles D, Jicha, Greg, Hardy, Peter, Sinha, Partha, Oates, Elizabeth, Conrad, Gary, Lopez, Oscar L, Oakley, MaryAnn, Roiz-Santiañez, Roberto, Simpson, Donna M, Porsteinsson, Anton P, Goldstein, Bonnie S, Martin, Kim, Makino, Kelly M, Ismail, M Saleem, Brand, Connie, Mulnard, Ruth A, Thai, Gaby, Mc-Adams-Ortiz, Catherine, Rose, Emma J, Womack, Kyle, Mathews, Dana, Quiceno, Mary, Diaz-Arrastia, Ramon, King, Richard, Weiner, Myron, Martin-Cook, Kristen, DeVous, Michael, Levey, Allan I, Lah, James J, Salami, Alireza, Cellar, Janet S, Burns, Jeffrey M, Anderson, Heather S, Swerdlow, Russell H, Apostolova, Liana, Tingus, Kathleen, Woo, Ellen, Silverman, Daniel H S, Lu, Po H, Bartzokis, George, Sämann, Philipp G, Graff-Radford, Neill R, Parfitt, Francine, Kendall, Tracy, Johnson, Heather, Farlow, Martin R, Hake, Ann Marie, Matthews, Brandy R, Herring, Scott, Hunt, Cynthia, van Dyck, Christopher H, Jahanshad, Neda, Schmaal, Lianne, Carson, Richard E, MacAvoy, Martha G, Chertkow, Howard, Bergman, Howard, Hosein, Chris, Black, Sandra, Stefanovic, Bojana, Caldwell, Curtis, Hsiung, Yuek Robin, Feldman, Howard, Schork, Andrew J, Mudge, Benita, Assaly, Michele, Kertesz, Andrew, Rogers, John, Trost, Dick, Bernick, Charles, Munic, Donna, Kerwin, Diana, Mesulam, Marek-Marsel, Lipowski, Kristine, Shin, Jean, Wu, Chuang-Kuo, Johnson, Nancy, Sadowsky, Carl, Martinez, Walter, Villena, Teresa, Turner, Raymond Scott, Johnson, Kathleen, Reynolds, Brigid, Sperling, Reisa A, Johnson, Keith A, Strike, Lachlan T, Marshall, Gad, Frey, Meghan, Yesavage, Jerome, Taylor, Joy L, Lane, Barton, Rosen, Allyson, Tinklenberg, Jared, Sabbagh, Marwan N, Belden, Christine M, Jacobson, Sandra A, Teumer, Alexander, Sirrel, Sherye A, Kowall, Neil, Killiany, Ronald, Budson, Andrew E, Norbash, Alexander, Johnson, Patricia Lynn, Obisesan, Thomas O, Wolday, Saba, Allard, Joanne, Lerner, Alan, van Donkelaar, Marjolein M J, Ogrocki, Paula, Hudson, Leon, Fletcher, Evan, Carmichael, Owen, Olichney, John, Kittur, Smita, Borrie, Michael, Lee, T-Y, Bartha, Rob, van Eijk, Kristel R, Johnson, Sterling, Asthana, Sanjay, Carlsson, Cynthia M, Preda, Adrian, Nguyen, Dana, Tariot, Pierre, Reeder, Stephanie, Bates, Vernice, Walters, Raymond K, Capote, Horacio, Rainka, Michelle, Scharre, Douglas W, Kataki, Maria, Adeli, Anahita, Zimmerman, Earl A, Celmins, Dzintra, Brown, Alice D, Pearlson, Godfrey D, Blank, Karen, Westlye, Lars T, Anderson, Karen, Santulli, Robert B, Kitzmiller, Tamar J, Schwartz, Eben S, Sink, Kaycee M, Williamson, Jeff D, Garg, Pradeep, Watkins, Franklin, Ott, Brian R, Querfurth, Henry, Whelan, Christopher D, Tremont, Geoffrey, Salloway, Stephen, Malloy, Paul, Correia, Stephen, Rosen, Howard J, Miller, Bruce L, Mintzer, Jacobo, Spicer, Kenneth, Bachman, David, Finger, Elizabether, Toro, Roberto, Winkler, Anderson M, Pasternak, Stephen, Rachinsky, Irina, Drost, Dick, Pomara, Nunzio, Hernando, Raymundo, Sarrael, Antero, Schultz, Susan K, Ponto, Laura L Boles, Zwiers, Marcel P, Shim, Hyungsub, Smith, Karen Elizabeth, Relkin, Norman, Chaing, Gloria, Raudin, Lisa, Smith, Amanda, Fargher, Kristin, Raj, Balebail Ashok, Amin, Najaf, Becker, Diane, Alhusaini, Saud, Beiser, Alexa, Debette, Stéphanie, DeStefano, Anita, Hofer, Edith, Hofman, Albert, Niessen, Wiro J, Smith, Albert, Tzourio, Christophe, Vaidya, Dhananjay, Athanasiu, Lavinia, Vernooij, Meike W, Goldstein, David B, Heinzen, Erin L, Shianna, Kevin, Radtke, Rodney, Ottmann, Ruth, Albrecht, Lisa, Andrew, Chris, Arroyo, Mercedes, Artiges, Eric, Ehrlich, Stefan, Aydin, Semiha, Bach, Christine, Banaschewski, Tobias, Barbot, Alexis, Barker, Gareth, Boddaert, Nathalie, Bokde, Arun, Bricaud, Zuleima, Bromberg, Uli, Bruehl, Ruediger, Hakobjan, Marina M H, Büchel, Christian, Cachia, Arnaud, Cattrell, Anna, Conrod, Patricia, Constant, Patrick, Crombag, Hans, Czech, Katharina, Dalley, Jeffrey, Decideur, Benjamin, Desrivieres, Sylvane, Hartberg, Cecilie B, Fadai, Tahmine, Flor, Herta, Frouin, Vincent, Fuchs, Birgit, Gallinat, Jürgen, Garavan, Hugh, Briand, Fanny Gollier, Gowland, Penny, Head, Kay, Heinrichs, Bert, Haukvik, Unn K, Heym, Nadja, Hübner, Thomas, Ihlenfeld, Albrecht, Ireland, James, Ittermann, Bernd, Ivanov, Nikolay, Jones, Jennifer, Klaassen, Arno, Heister, Angelien J G A M, Lalanne, Christophe, Lathrop, Mark, Lanzerath, Dirk, Lemaitre, Hervé, Lüdemann, Katharina, Mallik, Catherine, Mangin, Jean-François, Mann, Karl, Mar, Adam, Hoehn, David, Martinot, Jean-Luc, Massicotte, Jessica, Mennigen, Eva, Mesquita de Carvahlo, Fabiana, Mignon, Xavier, Miranda, Ruben, Müller, Kathrin, Nees, Frauke, Nymberg, Charlotte, Paillere, Marie-Laure, Wittfeld, Katharina, Kasperaviciute, Dalia, Pena-Oliver, Yolanda, Poline, Jean-Baptiste, Poustka, Luise, Rapp, Michael, Reed, Laurence, Robert, Gabriel, Reuter, Jan, Liewald, David C M, Ripke, Stephan, Ripley, Tamzin, Robbins, Trevor, Rodehacke, Sarah, Romanowski, Alexander, Ruggeri, Barbara, Schilling, Christina, Schmäl, Christine, Schmidt, Dirk, Lopez, Lorna M, Schneider, Sophia, Schroeder, Markus, Schubert, Florian, Schwartz, Yannick, Smolka, Michael, Sommer, Wolfgang, Spanagel, Rainer, Speiser, Claudia, Spranger, Tade, Stedman, Alicia, Makkinje, Remco R R, Steiner, Sabina, Stephens, Dai, Strache, Nicole, Ströhle, Andreas, Struve, Maren, Subramaniam, Naresh, Theobald, David, Topper, Lauren, Vollstaedt-Klein, Sabine, Walaszek, Bernadeta, Matarin, Mar, Weiß, Katharina, Werts, Helen, Whelan, Robert, Williams, Steve, Yacubian, Juliana, Ziesch, Veronika, Zilbovicius, Monica, Wong, C Peng, Lubbe, Steven, Naber, Marlies A M, Martinez-Medina, Lourdes, Kepa, Agnes, Fernandes, Alinda, Tahmasebi, Amir, Abrahamowicz, Michal, Gaudet, Daniel, Leonard, Gabriel, Perron, Michel, Richer, Louis, Seguin, Jean, McKay, D Reese, Veillette, Suzanne, Needham, Margaret, Nugent, Allison C, Pütz, Benno, Abramovic, Lucija, Royle, Natalie A, Sprooten, Emma, Trabzuni, Daniah, van der Marel, Saskia S L, van Hulzen, Kimm J E, Walton, Esther, Wolf, Christiane, Almasy, Laura, Ames, David, Andersson, Micael, Arepalli, Sampath, Assareh, Amelia A, Bastin, Mark E, Brodaty, Henry, Bulayeva, Kazima B, Carless, Melanie A, Cichon, Sven, Corvin, Aiden, Curran, Joanne E, Czisch, Michael, MUMC+: DA Klinische Genetica (5), RS: GROW - Developmental Biology, RS: GROW - R4 - Reproductive and Perinatal Medicine, Université de Montréal. Faculté de médecine. Département de psychiatrie et d'addictologie, David Geffen School of Medicine [Los Angeles], University of California [Los Angeles] (UCLA), University of California (UC)-University of California (UC), QIMR Berghofer Medical Research Institute, Department of Psychiatry, Donders Centre for Neuroscience, Radboud University [Nijmegen]-Radboud University Medical Center [Nijmegen]-Radboud University [Nijmegen]-Radboud University Medical Center [Nijmegen], Department of Human Genetics, Radboud University Medical Center [Nijmegen], Institute of Psychiatry, Psychology & Neuroscience, King's College London, King‘s College London, PRES Sorbonne Paris Cité, Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Gènes, Synapses et Cognition (CNRS - UMR3571 ), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Greifswald University Hospital, University Medical Center [Utrecht], European Commission, University of Edinburgh, Lagos State University (LASU), Heriot-Watt University [Edinburgh] (HWU), Unité d'expérimentation sur les Ruminants de Theix, Institut National de la Recherche Agronomique (INRA), Donders Institute for Brain, Cognition and Behaviour, Radboud University [Nijmegen], University of Oslo (UiO), Montreal Neurological Institute and Hospital, McGill University = Université McGill [Montréal, Canada], School of Technical Physics, Xidian University, Dept. of Mechanical Engineering, McMaster University [Hamilton, Ontario], Biological Psychology, Neuroscience Campus Amsterdam & EMGO Institute for Health and Care Research, VU University & VU Medical Center, Amsterdam 1081 BT, The Netherlands, Haukeland University Hospital, University of Bergen (UiB), Physicochimie des Processus de Combustion et de l’Atmosphère - UMR 8522 (PC2A), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Universität Heidelberg [Heidelberg] = Heidelberg University, Language and Genetics Department [Nijmegen], Max Planck Institute for Psycholinguistics, Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, International Max Planck Research School for Language Sciences (IMPRS ), Georgia Institute of Technology [Atlanta], National Institutes of Health [Bethesda] (NIH), Yale University [New Haven], Massachusetts General Hospital [Boston], Mental Health Sciences Unit, University College of London [London] (UCL), Beijing Normal University (BNU), Indiana University School of Medicine, Indiana University System, Indiana Alzheimer Disease Center, Indiana University System-Indiana University System, Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center, Goettingen 37075, Germany, Scottish Fish Immunology Research Centre, School of Biological Sciences, University of Aberdeen, University of California (UC), Medstar Research Institute, Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia, Department of Genomics, Life and Brain Center, Universität Bonn = University of Bonn, Institute of Human Genetics, Department of Biomedicine and the Centre for Integrative Sequencing, Aarhus University [Aarhus], VU University Medical Center [Amsterdam], Respiratory Epidemiology and Public Health, Imperial College London-School of public health, The University of Hong Kong (HKU)-The University of Hong Kong (HKU)-MRC-HPA Centre for Environment and Health, Centro de Investigación Biomédica en Red Salud Mental [Madrid] (CIBER-SAM), Institut Parisien de Chimie Moléculaire (IPCM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Umeå Centre for Functional Brain Imaging (UFBI), Umeå University, Umeå 901 87, Sweden, Aging Research Center [Karolinska Institutet] (ARC ), Stockholm University-Karolinska Institutet [Stockholm], Max Planck Institute of Psychiatry, Max-Planck-Gesellschaft, Department of Neurosciences [Univ California San Diego] (Neuro - UC San Diego), School of Medicine [Univ California San Diego] (UC San Diego), University of California [San Diego] (UC San Diego), University of California (UC)-University of California (UC)-University of California [San Diego] (UC San Diego), Department of Cognitive Sciences [Univ California San Diego] (CogSci - UC San Diego), The Hospital for sick children [Toronto] (SickKids), Queensland Institute of Medical Research, School of Psychology, University of Queensland, Brisbane 4072, Australia, University of Queensland [Brisbane], Centre for Advanced Imaging, University of Queensland, Brisbane 4072, Australia, Department of Genomics of Common Disease, Imperial College London, Department of Psychology [Oslo], Faculty of Social Sciences [Oslo], University of Oslo (UiO)-University of Oslo (UiO), Deutsche Bundesbank, Department of Neurology and Neurosurgery [Montreal], McGill University = Université McGill [Montréal, Canada]-McGill University = Université McGill [Montréal, Canada], Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland (RCSI), MetaGenoPolis, Department of Psychiatric Research and Development, Diakonhjemmet Hospital, Oslo 0319, Norway, UCL Institute of Neurology and Epilepsy Society, Department of Medicine, Clinical And Experimental Epilepsy, Dpt of Psychiatry [New Haven], Yale School of Medicine [New Haven, Connecticut] (YSM), Hartford Hospital, Neuropsychiatric Genetics Research Group and Department of Psychiatry, Trinity College Institute of Psychiatry, Trinity College Dublin, Dublin 2, Ireland, Institute of Food & Health, University College Dublin, University College Dublin [Dublin] (UCD), Statistical Genetics Group, State Key Laboratory of Lead Compound Research, WuXi AppTec, Co., Ltd, Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL, Institute of Neurology [London], Department of Genetics, King Faisal Specialist Hospital and Research Centre (KFSH & RC), Centre épigénétique et destin cellulaire (EDC), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Dundee Technopole, CXR Biosciences Ltd, Ninewells Hospital and Medical School, Biomedical Research Centre, University of Dundee, Southwest Foundation for Biomedical Research, Department of Psychiatry and National Ageing Research Institute, University of Melbourne, Department of Clinical Genetics, Department of Medical Parasitology and Mycology, School of public health, The University of Hong Kong (HKU)-The University of Hong Kong (HKU)-Tehran University of Medical Siences, Centre for Healthy Brain Ageing, University of New South Wales [Sydney] (UNSW), Dementia Collaborative Research Centre, N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119333, Russia, Texas Biomedical Research Institute [San Antonio, TX], Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Division of Medical Genetics, University of Basel (Unibas), Trinity College Dublin-St. James's Hospital, Neuropsychiatric Genetics Research Group, Trinity College Dublin, Department of Materials Science & Metallurgy, University of Cambridge [UK] (CAM), Bijvoet Center of Biomolecular Research [Utrecht], Utrecht University [Utrecht], School of Psychology, University of Queensland, Laboratory of Neurogenetics, The University of Texas Health Science Center at Houston (UTHealth), Department of Genomics, Department of Medical and Molecular Genetics, South Texas Veterans Health Care System, San Antonio, Texas 78229, USA, Biofunctional Imaging, Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan, Public Health Genomics Unit, Department of Biomolecular Engineering, Rheinische Friedrich-Wilhelms-Universität Bonn, Estación Experimental de Pastos y Forrajes 'Indio Hatuey', University Medical Center Groningen [Groningen] (UMCG), Neuronal Plasticity / Mouse Behaviour, Interfaculty Institute for Genetics and Functional Genomics, Universität Greifswald - University of Greifswald, Department of Psychiatry, Fujita Health University School of Medicine, Toyoake 470-1192, Japan, Department of Radiology, Mayo Clinic, Department of Clinical Neurology [Oxford], University of Oxford-FMRIB Centre- John Radcliffe Hospital [Oxford University Hospital], University of Maryland School of Medicine, University of Maryland System, University of Sussex, Institute of Cognitive Neuroscience, United Kingdom Met Office [Exeter], University of Maryland [Baltimore County] (UMBC), University of Maryland System-University of Maryland System-University of Maryland School of Medicine, Department of Civil and Structural Engineering, The Hong Kong Polytechnic University [Hong Kong] (POLYU)-The Hong Kong Polytechnic University [Hong Kong] (POLYU), Columbia University Irving Medical Center (CUIMC), Lymphocyte Cell Biology Unit, Laboratory of Genetics, Centre for Advanced Imaging, Psychiatry and Psychotherapy, KG Jebsen Centre for Psychosis Research, University of Oslo (UiO)-Institute of Clinical Medicine-Oslo University Hospital [Oslo], Division of Mental Health and Addiction, Oslo University Hospital [Oslo], Institute of Clinical Medicine [Oslo], Faculty of Medicine [Oslo], Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Genetic Epidemiology Unit, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Department of Statistics [Warwick], University of Warwick [Coventry], Osaka University [Osaka], Institute of Psychiatry, King’s College London, London SE5 8AF, UK, University of Calgary, Psychiatry and Human Behavior, University of California, Irvine, California 92617, USA, University of California [Irvine] (UC Irvine), Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health [Mannheim], University Hospital Mannheim | Universitätsmedizin Mannheim-University Hospital Mannheim | Universitätsmedizin Mannheim, Space and Naval Warfare Systems Center, Klinik für Psychiatrie, Martin-Luther-University Halle-Wittenberg, Department of Psychiatry, Division of Medical Psychology, Genetics of Mental Illness and Brain Function, Neuroscience Research Australia, Développement et amélioration des plantes (UMR DAP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney 2052, Australia, Laboratory of Neuro Imaging [Los Angeles] (LONI), Departamento de Física Aplicada, Universidade de Vigo, Georgia State University, University System of Georgia (USG), Genentech, Inc. [San Francisco], Psychiatry and Leiden Institute for Brain and Cognition, Leiden University Medical Center (LUMC), Universiteit Leiden-Universiteit Leiden, Universiteit Leiden, Carver College of Medicine [Iowa City], University of Iowa [Iowa City]-University of Iowa [Iowa City], Department of Neurobiology, Care Sciences and Society, Karolinska Institutet [Stockholm], University of Manchester [Manchester], The University of Tennessee Health Science Center [Memphis] (UTHSC), iangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong 226001, China, Centre for Ultrahigh Bandwidth Devices for Optical Systems (CUDOS), Macquarie University, Cognitive Neuroscience Laboratory (CNL), Harvard University, Donders Center for Cognitive Neuroimaging, Donders Centre for Cognitive Neuroimaging, Radboud University [Nijmegen]-Radboud University [Nijmegen], Icahn School of Medicine at Mount Sinai [New York] (MSSM), The Mind Research Network, Department of Electrical and Computer Engineering [Albuquerque] (ECE Department), The University of New Mexico [Albuquerque], Division of Molecular and Cellular Therapeutics, Scottish Association for Marine Science (SAMS), Structural Biology Laboratory, Department of Chemistry, University of York, Neurology Division, Beaumont Hospital, Dublin 9, Ireland, Beaumont Hospital, Department of Neurology, Hôpital Erasme [Bruxelles] (ULB), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB)-Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Deparment of Medical Genetics, Human Genetics Branch, National Institutes of Health [Bethesda] (NIH)-National Institute of Mental Health (NIMH), Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital [Boston], Department of Psychiatry, University of Iowa, University of Iowa [Iowa City], Institute for Community Medicine, Department Epidemiology of Health Care and Community Health, Translational Centre for Regenerative Medicine (TRM), Department of Cell Therapy, Universität Leipzig-Universität Leipzig, Institute of Clinical Chemistry and Laboratory Medicine, Department of Health Science, Division of Health and Rehabilitation, Luleå University of Technology (LUT), Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston]-Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Psychiatric and Neurodevelopmental Genetics Unit, 849 Department of Human Genetics, Institute for Community Medicine, Institute for Energy Systems and Thermodynamics, Renyi Institute, Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, NSW, Department of Child and Adolescent Psychiatry, Erasmus University Medical Centre, Rotterdam 3000 CB, The Netherlands, Department of Radiology, Erasmus University Medical Centre, Rotterdam 3015 CN, The Netherlands, Vrije Universiteit Amsterdam [Amsterdam] (VU), Cell Biology and Gene Expression Section, National Institute of Health, Bethesda, Dept of Psychology, Laboratoire de Recherche Magellan, Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Institut d'Administration des Entreprises (IAE) - Lyon, Institut de Socio-économie des Entreprises et des ORganisations (ISEOR), Institut de socio-économie des entreprises et des organisations, Department of Psychiatry and Psychotherapy, HELIOS Klinikum Stralsund Hanseatic-Greifswald University Hospital, Laboratoire d'Informatique de Grenoble (LIG), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS), Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Centre for Allergy Research, Department of Medicine, Clinical Pharmacology Unit, Karolinska University Hospital [Stockholm], Medical University of Łódź (MUL), Psychiatry Institute, Department of Health and Human Services, Institute of Gerontology and Geriatrics, Università degli Studi di Perugia = University of Perugia (UNIPG), Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), Australian Centre for Research into Injury in Sport and its Prevention, Monash University [Clayton], University Medical Center [Utrecht]-Brain Center Rudolf Magnus, School of Psychology [Nottingham], University of Nottingham, UK (UON), McConnell Brain Imaging Centre (MNI), SickKids - The Hospital for sick children, European Centre for Medium-Range Weather Forecasts (ECMWF), University of Eastern Finland, Centre for Population Health Sciences, Lieber Institute for Brain Development [Baltimore] (LIBD), Johns Hopkins University (JHU), Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique, Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz 8010, Austria, Austrian Institute of Technology [Vienna] (AIT), INSERM Research Center for Epidemiology and Biostatistics (U897) Team Neuroepidemiology, Bordeaux, France College of Health Sciences, University of Bordeaux, Bordeaux, France, INSERM, Neuroepidemiology U708, Bordeaux, France, Karlsruhe Institute of Technology (KIT), General Internal Medicine, Johns Hopkins School of Medicine, Johns Hopkins University School of Medicine [Baltimore], Harvard Medical School [Boston] (HMS), Computer Science and Artificial Intelligence Laboratory [Cambridge] (CSAIL), Massachusetts Institute of Technology (MIT), University of Washington [Seattle], Department of Physics [Stockholm], Stockholm University, Center for Medical Systems Biology, Netherlands Genomics Initiative, Leiden University Medical Center, Leiden, The Netherlands, Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands, Boston University [Boston] (BU), Groupe d'Imagerie Neurofonctionnelle (GIN - UMR 5296), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Faculty of Medicine, University of Iceland [Reykjavik], Icelandic Heart Association, Kopavogur, Iceland., Boston University School of Medicine (BUSM), Laboratoire d'Ingénierie des Matériaux de Bretagne (LIMATB), Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université de Brest (UBO), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], University of California-University of California, Radboud university [Nijmegen]-Radboud University Medical Center [Nijmegen]-Radboud university [Nijmegen]-Radboud University Medical Center [Nijmegen], Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Gènes, Synapses et Cognition, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), UE 1354 Unité d'expérimentation sur les Ruminants de Theix, Institut National de la Recherche Agronomique (INRA)-Physiologie Animale et Systèmes d'Elevage (PHASE), Institut National de la Recherche Agronomique (INRA)-Unité d'expérimentation sur les Ruminants de Theix (UE RT), Radboud university [Nijmegen], McGill University, University of Bergen (UIB), Universität Heidelberg [Heidelberg], Beijing Normal University, University of California, University of Bonn, Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Department of Neurosciences [San Diego], Department of Cognitive Sciences [San Diego], The Hospital for Sick Children, University of Toronto, Toronto M5G 1X8, Canada, McGill University-McGill University, US 1367 MetaGénoPolis, Institut National de la Recherche Agronomique (INRA)-Département Microbiologie et Chaîne Alimentaire (MICA), Institut National de la Recherche Agronomique (INRA)-MetaGénoPolis (MGP), Yale University School of Medicine, King Faisal Specialist Hospital and Research Centre, Centre épigénétique et destin cellulaire (EDC (UMR_7216)), Texas Biomedical Research Institute [San Antonio, Texas], Bijvoet Center of Biomolecular Research, Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne 3101, Australia, Department of Genomics, Life & Brain Center, University of Bonn, Bonn D-53127, Germany, University of Oxford [Oxford]-FMRIB Centre- John Radcliffe Hospital [Oxford University Hospital], School of Psychology, University of Sussex, Brighton BN1 9QH, UK, Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin, Department of Neurology [University of Calgary], Department of Clinical Neuroscience [University of Calgary], University of California [Irvine] (UCI), Medical Faculty [Mannheim]-Medical Faculty [Mannheim], Centre National de la Recherche Scientifique (CNRS)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Recherche Agronomique (INRA)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Universidate de Vigo, Harvard University [Cambridge], Radboud university [Nijmegen]-Radboud university [Nijmegen], Université Libre de Bruxelles [Bruxelles] (ULB)-Hôpital Erasme (Bruxelles), Universität Leipzig [Leipzig]-Universität Leipzig [Leipzig], Centre de Recherche Magellan, Institut d'Administration des Entreprises (IAE) - Lyon-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon, Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Università degli Studi di Perugia (UNIPG), Department of neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland, Department of neurology, University of Eastern Finland-University Hospital of Kuopio-University of Eastern Finland-University Hospital of Kuopio, Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-Service NEUROSPIN (NEUROSPIN), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université de Bretagne Sud (UBS)-Institut Brestois du Numérique et des Mathématiques (IBNM), Université de Brest (UBO)-Université de Brest (UBO)-Université de Brest (UBO), The Alzheimer’s Disease Neuroimaging Initiative, The CHARGE Consortium, EPIGEN, IMAGEN, SYS, Radboud University Medical Center [Nijmegen]-Radboud university [Nijmegen]-Radboud University Medical Center [Nijmegen]-Radboud university [Nijmegen], Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), FMRIB Centre- John Radcliffe Hospital [Oxford University Hospital]-University of Oxford [Oxford], Massachusetts General Hospital [Boston]-Harvard Medical School [Boston] (HMS), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut Pasteur [Paris], Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), University of Oxford [Oxford]- John Radcliffe Hospital [Oxford University Hospital]-FMRIB Centre, Neurology, Psychiatry, Anatomy and neurosciences, NCA - Neurobiology of mental health, EMGO - Mental health, NCA - Brain imaging technology, Biological Psychology, Cognitive Psychology, Neuroscience Campus Amsterdam - Neurobiology of Mental Health, Neuroscience Campus Amsterdam - Brain Imaging Technology, EMGO+ - Mental Health, Child and Adolescent Psychiatry / Psychology, Epidemiology, Radiology & Nuclear Medicine, Laboratory of Neuro Imaging, David Geffen School of Medicine, University of California, Los Angeles, California, USA, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Centre, MRC- SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, UK, Génétique humaine et Fonctions cognitives - Human Genetics and Cognitive Functions, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique ( CNRS ), Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, Greifswald 17487, Germany, Department of Psychiatry, University Medicine Greifswald, Greifswald 17489, Germany, Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands, Brain Research Imaging Centre, University of Edinburgh, Edinburgh EH4 2XU, UK, Department of Computer Science, Lagos State University, Lagos, Nigeria, Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, University of Edinburgh, Edinburgh EH4 2XU, UK, Heriot-Watt University [Edinburgh] ( HWU ), Institut National de la Recherche Agronomique ( INRA ) -Physiologie Animale et Systèmes d'Elevage ( PHASE ) -Unité d'expérimentation sur les Ruminants de Theix ( UE RT ), Department of Human Genetics, Radboud university medical center, Nijmegen 6500 HB, The Netherlands, Department of Cognitive Neuroscience, Radboud university medical center, Nijmegen 6500 HB, The Netherlands, NORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo N-0316, Norway, NORMENT - KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo 0424, Norway, Montreal Neurological Institute [Montréal], NORMENT - KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway, Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen 5021, Norway, Physicochimie des Processus de Combustion et de l’Atmosphère - UMR 8522 ( PC2A ), Université de Lille-Centre National de la Recherche Scientifique ( CNRS ), Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen 6525 XD, The Netherlands, International Max Planck Research School for Language Sciences, Nijmegen 6525 XD, The Netherlands, Human Genetics Branch and Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland 20892, USA, Department of Psychology, Yale University, New Haven, Connecticut 06511, USA, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02115, USA, University College of London [London] ( UCL ), Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA, Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA, Center for Neurobehavioral Genetics, University of California, Los Angeles, California 90095, USA, Université de Bonn, Department of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam 1081 HL, The Netherlands, Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh EH10 5HF, UK, Imperial College London-School of public health-MRC-HPA Centre for Environment and Health, Cibersam (Centro Investigación Biomédica en Red Salud Mental), Madrid 28029, Spain, Institut Parisien de Chimie Moléculaire ( IPCM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Centre National de la Recherche Scientifique ( CNRS ), Aging Research Center [Karolinska Institutet] ( ARC ), Max Planck Institute of Psychiatry, Munich 80804, Germany, Multimodal Imaging Laboratory, Department of Neurosciences, University of California, San Diego, California 92093, USA, Department of Cognitive Sciences, University of California, San Diego, California 92161, USA, Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia, Department of Psychology, University of Oslo, Oslo 0373, Norway, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal H3A 2B4, Canada, Molecular and Cellular Therapeutics, The Royal College of Surgeons, Dublin 2, Ireland, Institut National de la Recherche Agronomique ( INRA ) -MetaGénoPolis ( MGP ) -Microbiologie et Chaîne Alimentaire ( MICA ), UCL Institute of Neurology, London, United Kingdom and Epilepsy Society, London WC1N 3BG, UK, Department of Medicine, Imperial College London, London W12 0NN, UK, Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK, Yale School of Medicine, Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, Connecticut 06106, USA, University College Dublin [Dublin] ( UCD ), Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK, Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia, Centre épigénétique et destin cellulaire ( EDC ), Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), School of public health-Tehran University of Medical Siences, University of New South Wales [Sydney] ( UNSW ), Texas Biomedical Research Institute, San Antonio, Texas 78245, USA, Institute of Neuroscience and Medicine ( INM-1 ), University of Basel ( Unibas ), Cambridge University, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA, University of Texas Health Science Center, San Antonio, Texas 78229, USA, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 20892, USA, Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald 17475, Germany, University Medical Center Groningen, University of Groningen, University of Greifswald, Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA, NICHD Brain and Tissue Bank for Developmental Disorders, University of Maryland Medical School, Baltimore, Maryland 21201, USA, nstitute of Cognitive Neuroscience, University College London, London WC1N 3AR, UK, Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland, Baltimore, Maryland 21201, USA, Department of Pathology and Cell Biology, Columbia University Medical Center, New York 10032, USA, Lymphocyte Cell Biology Unit, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA, University of Oslo ( UiO ) -Institute of Clinical Medicine-Oslo University Hospital, Oslo University Hospital, Institute of Clinical Medicine, University of Oslo ( UiO ) -European Network of Bipolar Research Expert Centers (ENBREC) Group, Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, CCM, Berlin 10117, Germany, Erasmus MC, Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health (NIH), Bethesda, Maryland, USA, Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA, Central Institute of Mental Health, UMR 1098 Développement et Amélioration des Plantes, Institut National de la Recherche Agronomique ( INRA ) -Université Montpellier 2 - Sciences et Techniques ( UM2 ) -MontpellierSupAgro ( MontpellierSupAgro ) -Génétique et amélioration des plantes ( G.A.P. ) -Développement et Amélioration des Plantes ( DAP ), Laboratory of Neuro Imaging [Los Angeles] ( LONI ), University of California at Los Angeles [Los Angeles] ( UCLA ), Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH4 2XU, UK, Genentech, South San Francisco, California 94080, USA, Psychiatry and Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands, LUMC, Carver College of Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm SE-141 83, Sweden, Behavioral Epidemiology Section, National Institute on Aging Intramural Research Program, Baltimore, Maryland 20892, USA, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK, Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA, Department of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA, Centre Interlangues - Texte, Image, Langage ( TIL ), Université de Bourgogne ( UB ), Centre for Ultrahigh Bandwidth Devices for Optical Systems ( CUDOS ), Icahn School of Medicine at Mount Sinai [New York], The Mind Research Network & LBERI, Albuquerque, New Mexico 87106, USA, Department of ECE, University of New Mexico, Albuquerque, New Mexico 87131, USA, Scottish Association for Marine Science ( SAMS ), Department of Neurology, Hopital Erasme, Universite Libre de Bruxelles, Brussels 1070, Belgium, National Institutes of Health ( NIH ) -National Institute of Mental Health (NIMH), Harvard Medical School [Boston] ( HMS ) -Massachusetts General Hospital [Boston], Department of Psychiatry, University of Iowa, Iowa City, Iowa 52242, USA, Luleå University of Technology ( LUT ), Broad Institute of MIT and Harvard, Massachusetts General Hospital, Vrije Universiteit Amsterdam [Amsterdam] ( VU ), Université Jean Moulin - Lyon III-Institut d'Administration des Entreprises (IAE) - Lyon, Institut de Socio-économie des Entreprises et des ORganisations ( ISEOR ), University Medicine Greifswald,-HELIOS Hospital Stralsund, Laboratoire d'Informatique de Grenoble ( LIG ), Université Pierre Mendès France - Grenoble 2 ( UPMF ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut National Polytechnique de Grenoble ( INPG ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Osaka 565-0871, Japan, Karolinska University Hospital (Solna), Medical University of Łódź ( MUL ), National Institutes of Health ( NIH ), University of Perugia, Commonwealth Scientific and Industrial Research Organisation, University Medical Center Utrecht-Brain Center Rudolf Magnus, University of Nottingham, UK ( UON ), McConnell Brain Imaging Centre ( MNI ), The Hospital for sick children [Toronto] ( SickKids ), Department of Medical and Molecular Genetics, King’s College London, London SE1 9RT, UK, European Centre for Medium-Range Weather Forecasts ( ECMWF ), Lieber Institute for Brain Development, Baltimore, Maryland 21205, USA, Departments of Psychiatry, Neurology, Neuroscience and the Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA, Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique ( CNRS ), Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Austrian Institute of Technology [Vienna] ( AIT ), Karlsruhe Institute of Technology ( KIT ), General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA, Department of Radiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA, Computer Science and Artificial Intelligence Laboratory [Cambridge] ( CSAIL ), Massachusetts Institute of Technology ( MIT ), Department of Epidemiology, University of Washington, Seattle, Washington, USA, Department of Neurology, University of Washington, Seattle, Washington, USA, Department of Physics, Stockholm University ( Department of Physics, Stockholm University ), Université de Lille, Sciences Humaines et Sociales, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA, Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA, Groupe d'Imagerie Neurofonctionnelle ( GIN - UMR 5296 ), Service NEUROSPIN ( NEUROSPIN ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Centre National de la Recherche Scientifique ( CNRS ) -Université de Bordeaux ( UB ), Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA, Faculty of Medicine, University of Iceland, Reykjavik, Iceland, Department of Neurology, Boston University School of Medicine, Framingham Heart Study, Boston, MA, Department of Neurology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands, Laboratoire d'Ingénierie des Matériaux de Bretagne ( LIMATB ), Université de Bretagne Sud ( UBS ) -Institut Brestois du Numérique et des Mathématiques ( IBNM ), Université de Brest ( UBO ) -Université de Brest ( UBO ) -Université de Brest ( UBO ), King's College, Department of Psychiatry, Radboud university medical center, Nijmegen 6500 HB, The Netherlands, and Broad Institute of © 2012 Nature America, Inc. All rights reserved. Nature Ge N etics aDV a NCE ONLINE PUBLIC a TION 7 l e t t e r s Harvard and MIT, Cambridge, Massachusetts, US
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CHROMATIN ,Male ,Netherlands Twin Register (NTR) ,Aging ,Identification ,nervous-system ,human geography ,SEGMENTATION ,Caudate nucleus ,Apoptosis ,Expression ,Genome-wide association study ,Striatum ,Hippocampal formation ,Hippocampus ,BASAL GANGLIA ,130 000 Cognitive Neurology & Memory ,Basal ganglia ,genetics [Gene Expression Regulation, Developmental] ,Hippocampal ,Child ,anatomy & histology [Skull] ,Aged, 80 and over ,Genetics ,Sex Characteristics ,KINECTIN ,Genome-wide association ,Multidisciplinary ,Putamen ,Brain ,Gene Expression Regulation, Developmental ,blood ,brain ,disease incidence ,genetic variation ,neurology ,Organ Size ,Human brain ,Middle Aged ,organization ,Magnetic Resonance Imaging ,genetics [Genetic Variation] ,Chromatin ,Dynamics ,genetics [Membrane Proteins] ,medicine.anatomical_structure ,genetics [Aging] ,Anatomy & histology ,[ SCCO.NEUR ] Cognitive science/Neuroscience ,Female ,ddc:500 ,anatomy & histology [Caudate Nucleus] ,Neuroinformatics ,EXPRESSION ,Adult ,Adolescent ,Evolution ,anatomy & histology [Hippocampus] ,ORGANIZATION ,genetics [Genetic Loci] ,Biology ,Article ,Young Adult ,SDG 3 - Good Health and Well-being ,Journal Article ,medicine ,Humans ,GENOME-WIDE ASSOCIATION ,General ,genetics [Apoptosis] ,Kinectin ,Aged ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,HIPPOCAMPAL ,IDENTIFICATION ,genetics [Organ Size] ,[SCCO.NEUR]Cognitive science/Neuroscience ,Skull ,segmentation ,Genetic Variation ,Membrane Proteins ,NERVOUS-SYSTEM ,anatomy & histology [Putamen] ,Genetic Loci ,KTN1 protein, human ,Caudate Nucleus ,anatomy & histology [Brain] ,Neuroscience ,Genome-Wide Association Study - Abstract
Contains fulltext : 144426.pdf (Publisher’s version ) (Closed access) Contains fulltext : 144426pre.pdf (Author’s version preprint ) (Open Access) The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour and disease. To investigate how common genetic variants affect the structure of these brain regions, here we conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magnetic resonance images of 30,717 individuals from 50 cohorts. We identify five novel genetic variants influencing the volumes of the putamen and caudate nucleus. We also find stronger evidence for three loci with previously established influences on hippocampal volume and intracranial volume. These variants show specific volumetric effects on brain structures rather than global effects across structures. The strongest effects were found for the putamen, where a novel intergenic locus with replicable influence on volume (rs945270; P = 1.08 x 10(-33); 0.52% variance explained) showed evidence of altering the expression of the KTN1 gene in both brain and blood tissue. Variants influencing putamen volume clustered near developmental genes that regulate apoptosis, axon guidance and vesicle transport. Identification of these genetic variants provides insight into the causes of variability in human brain development, and may help to determine mechanisms of neuropsychiatric dysfunction. 6 p.
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- 2015
37. TEDARİK ZİNCİRİ YÖNETİMİNDE BİLGİ SİSTEMLERİ VE DERİ HAZIR GİYİM SEKTÖRÜNE BİR YAZILIM ÖNERİSİ
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ÖZELMAS KAHYA, Saliha and AYDIN, Semiha
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Engineering ,Mühendislik ,Tedarik Zincir Yönetimi,Depo Yazılımı,Deri,Deri Hazır Giyim Sektörü ,Supply Chain Management,Stock Software,Leather,Leather Ready-Made Sector - Abstract
This research aims at creating a software enabling to manage raw material and auxiliary material store data of leather ready-made enterprise with the support of an integrated data/information system, completing the chain of supplier and customer, and also ensuring the control of stocks. “Case study”, which is one of the descriptive research methods, was applied in the research. A medium scaled leather ready-made enterprise registered in Aegean Association of Leather Industrialists in Izmir was chosen for the case study. Unstructured interview form was used in collection of data necessary for store software. Software model was prepared in accordance with the findings obtained by means of the interview form. Thanks to the prepared software, the enterprise will be able to form both supplier and customer information, make the entry of the materials coming from the supplier and exit operation of the used material, and easily reach the stock data of all the materials, Bu çalışmada; deri hazır giyim işletmesinin, hammadde ve yardımcı malzeme deposu bilgilerinin bü-tünleşik bir veri/bilgi sistemi desteğiyle yönetilmesi amacıyla tedarikçi ve müşteri zincirini tamamlayan, aynı zamanda stokların kontrolünü sağlayan bir yazılım oluşturmak hedeflenmiştir. Araştırmada, betimsel araştırma yönteminden ‘Vaka İncelemesi’ uygulanmıştır. İzmir’de Ege Deri Sanayicileri Derneği’ne kayıtlı orta ölçekli bir deri hazır giyim işletmesi örneklem olarak seçilmiştir. Depo yazılımı için gerekli verilerin toplanmasında “Yapılandırılmamış Görüşme Formu” kullanılmıştır. Görüşme formu ile elde edilen bulgular doğrultusunda yazılım modeli hazırlanmıştır. Hazırlanan yazılım sayesinde işletmede, hem tedarikçi hem de müşteri bilgilerini oluşturabilecek, tedarikçiden gelen malzemelerin giriş, kullanılan malzemelerin çıkış işlemlerini yapabilecek, tüm malzemelerin stok bilgilerine kolaylıkla ulaşılabilecektir.
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- 2014
38. Gebelerde gevşeme egzersizlerinin gebelerin uyku kalitesine etkisi
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Aydin, Semiha, Rathfısch, Gülay, and Kadın Sağlığı ve Hastalıkları Hemşireliği Anabilim Dalı
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Pregnancy complications ,Pregnancy ,Relaxation therapy ,Obstetrics and Gynecology ,Scales ,Nursing ,Sleep disorders ,Hemşirelik ,Sleep ,Exercise ,Kadın Hastalıkları ve Doğum - Abstract
Gebelik döneminde hormonal, fiziksel ve psikolojik değişiklikler uyku düzeninde ve uyku kalitesinde önemli değişiklere neden olur. Gebelik haftasının artması ile uyku promlemlerinde de artış görülür ve gebelerin uyku kalitesi olumsuz etkilenir. Yapılan çalışmalarda, kötü uyku kalitesinin maternal ve fetal sağlığı olumsuz etkilediği gösterilmiştir. Bu araştırmada gevşeme egzersizlerinin gebelerin uyku kalitesi üzerine etkisi araştırıldı. Araştırmada ön test ve son test kontrol gruplu deneysel bir tasarım düzeni kullanıldı Araştırma Eylül 2012- Temmuz 2013 tarihleri arasında T. C.S. B. Zeynep Kamil Eğitim ve Araştırma Hastanesi gebe izlem polikliniği bünyesindeki gebe eğitim sınıfında 84 gebe ile gerçekleştirildi. Pitsburg uyku kalitesi indeksi (PUKI) ve Epworth uykululuk ölçeği (EUÖ) ile ön testte tüm gebeler değerlendirildi. Deney grubu gebelerden dört hafta süresince akşamları Türk psikologlar derneği tarafından hazırlanan gevşeme egzersizleri CD'si eşliğinde gevşeme egzersizleri yapmaları istendi. Dört haftanın sonunda deney ve kontrol grubu gebeler PUKI ve EUÖ ile tekrar değerlendirildi. Araştırma sonucunda elde edilen veriler bilgisayar ortamında, Statistical Package for Social Sciences (SPSS) 15.0 programı ile değerlendirildi. Çalışmaya katılan tüm gebelerin ön testte %60,7'sinin uyku kalitesinin kötü olduğu ve PUKI ortalamasının ise 7,12±3,66 olduğu saptandı. Gevşeme egzersizleri sonrası deney grubu gebelerde; uyku kalitesinin arttığı, öznel uyku kalitesinin oldukça iyi olduğu, uyku latensinin kısaldığı, uyku süresinin ve alışılmış uyku etkinliğinin arttığı, uyku bozukluğunu haftada 1-2 kez yaşadığını belirten ve gündüz işlev bozukluğunu hiç yaşamadığını belirten gebe sayısının arttığı bulundu. Bu farkın istatistiksel olarak anlamlı olduğu saptandı (p
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- 2014
39. CEREBRAL GABA, RESTING-STATE FUNCTIONAL CONNECTIVITY AND MEMORY FUNCTION IN ALZHEIMER’S DISEASE
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Köbe, Theresa, Wang, Hui, Göschel, Laura, Aydin, Semiha, Ittermann, Bernd, Flöel, Agnes, and Fillmer, Ariane
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- 2018
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40. NEGATIVE RELATIONSHIP BETWEEN DECLARATIVE MEMORY PERFORMANCE AND HIPPOCAMPAL VOLUME EXTRACTED FROM 7 TESLA MR IMAGES OF HEALTHY OLDER ADULTS
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Göschel, Laura, Köbe, Theresa, Wang, Hui, Fillmer, Ariane, Aydin, Semiha, and Flöel, Agnes
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- 2018
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41. Annelerin 0-2 yaş bebek giysilerinde aradıkları özellikler
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AYDIN, SEMİHA
- Abstract
Giyim, insanoğlunun var olduğu andan beri bir ihtiyaç olarak kendini göstermiş bir olgudur. İnsan önceleri doğa şartlarından korunmak amacı ile giyinmiş ise de daha sonraları giyim, kişinin kendini ifade etme biçimi haline gelmiştir. Giyim tarihi incelendiğinde modanın sadece yetişkinler için değil, çocuk ve bebekler için de geçerli bir olgu olduğu görülmektedir. Hatta bazı ressamların soylu çocuklarını resmettikleri tablolarda giyimin çocuklar için son derece önemli olduğu anlaşılmaktadır. Giyim çocuklar için de bir tür kendilerini ifade biçimidir. Kendi zevklerince giyinmek, giysilerini kendilerinin seçmesi hem psikolojik hem de sosyal gelişimleri için son derece önemlidir. Bebeklik çağı denilen 0-2 yaş döneminde bebekler giysilerini kendileri seçebilecek yetide olmadıklarından giysi seçimleri ebeveynleri ve hatta daha çok anneleri tarafından yapılmaktadır,Giyim, günümüzde yetişkinler için olduğu kadar bebekler için de önemli bir hal almıştır. Ebeveynler bebekleri için en sağlıklı ve en güzel olanı istemektedirler. Bu nedenle bebeklerinin giyimine kendi giyimlerinden daha fazla önem verdikleri söylenebilir. Hassas ve narin olan bebek cildi için aileler en sağlıklı ve en zararsız ürünleri seçmek istemeleri son derece normaldir. Tüm bu farkındalık ve arayışların annelerin bebek ürünleri üzerine oluşan taleplerini çeşitlendirdiği ve arttırdığı söylenebilir.0-2 yaş dönemi bebeğin en hızlı gelişim ve büyüme gösterdiği dönem olması dolayısıyla hareketleri de yatmaktan, emeklemeye ve son olarak yürümeye kadar gelişip değiştiğinden kullanılan giysiler açısından da en fazla çeşitliliğin bu dönemde yaşandığısöylenebilir. Bu noktada bebek giysisi üreticilerine büyük bir görev düşmektedir. Bebek giysisi üreticilerinin yerli üretim yapmaları için ve ayaklata kalabilmeleri için kapsamlı bir pazar araştırması yapmaları gerekir. Bebek giysisi tüketicileri olan annelerin bebek giysilerinden beklentilerini bilmek sektör için çok önemlidir. Bu araştırma, 0-2 yaş arası bebek sahibi olan annelerin görüşlerine dayanarak bebeklerine aldıkları giysilerden beklentilerini anlamak ve ileride yapılacak olan çalışmalara katkıda bulunmak amacı ile yapılmıştır. Ayrıca bu çalışma tüketici taleplerini araştırması yönüyle sektördeki bebek giysisi üreticilerine de bir kaynak niteliğindedir. Tüm bunlara ek olarak araştırma, annelerin bilinç seviyeleri hakkında da bilgi sahibi olmayı amaçlamaktadır. Bu amaç doğrultusunda bir veri toplama aracı ile annelerin, bebek giysilerinde dış görünüşe( estetik oluşu, modeli, rengi, üzerindeki baskılar..vb.) verdikleri önem derecesi, kullanım kolaylığı açısından, leke tutmazlık, buruşmazlık, çabuk kuruma, fonksiyonellik, ergonomiklik gibi özelliklere verdikleri önem derecesi, doğal ham maddelerden üretilmiş olması, antibakteriyel olması, organik olması, üretiminde zararlı kimyasalların kullanılmamış olmasına verdikleri önem derecesi, markası ve ürüne ödenen paranın miktarı gibi konulardaki görüşleri alınarak hem talepleri anlaşılmaya çalışılmış hem de bilinç düzeyleri hakkında fikir sahibi olunmuştur.Araştırma, Ankara ilinde gerçekleştirilmiştir. Örneklem grubu, 0-2 yaş arası bebek sahibi annelere daha kolay ulaşabilmek adına, Ankara?nın Çankaya ilçesinde bulunan kreşlerde ve çocuk polikliniklerinde belirlenmiştir. Rastgele yöntemi ile belirlenmiş olan örneklem grubu 250 kişidir. Araştırma sonucunda elde edilmiş olan bulgular Ankara?nın Çankaya ilçesinde yaşayan ve 0-2 yaş arası bebek sahibi olan annelere genellenmiştir. Araştırmanın evrenini Ankara?nın Çankaya ilçesindeki 0-2 yaş grubu anneler oluşturmuştur. Evrenin, Çankaya ilçesinde yaşayan annelerden seçilmesinin sebebi, bu ilçedeki eğitim ve gelir seviyesinin yüksek olması ve alım gücü yüksek potansiyel tüketicilerin bu ilçede oturmasıdır. Bu araştırma sektöre yön gösterecek bulgulara ulaşmayı hedeflediğinden tüketici profilinin bilinçli ve alım gücü yüksek kişilerden oluşması gerekliliği düşünülmüştür. Araştırmadan elde edilen veriler E-views (Econometric Views) istatistik paket programı kullanılarak analiz edilmiştir. Örneklem grubunun demografik özellikleri frekans tabloları halinde sunulmuştur. Araştırma sonucunda elde edilen verilerin yüzde ve frekans dağılımları alınmış, örneklem grubunun demografik özellikleri ile veri toplama aracında yer alan sorulara verdikleri yanıtlar arasında istatistiksel açıdananlamlı bir ilişki olup olmadığını belirlemek için, crosstab (çapraz tablolar) iledeğişkenler arasındaki ilişki durumu analiz edilmiştir.Araştırma sonucunda ulaşılan verilere göre annelerin bebek giysilerine uygulanan ve kullanım kolaylığı yaratan bitim işlemlerini tercih ettikleri, bebek giysilerinin organik olmasını talep etmelerine rağmen, organik ürünleri ve sertifikalarını tanımadıkları, doğal ham maddelerden oluşan tekstil ürünleri kullanmayı beklenen oranda önemsemedikleri ve giysilere uygulanan boya, baskı ve kullanılan zararlı kimyasallar konularında yeterli bilgi birikimi ve farkındalığa sahip olmadıkları görülmüştür.0-2 yaş bebek annelerin, organiklik, ökotex belgesi ve sertifikasyon işlemleri, tekstilde kullanılan zararlı kimyasallar, bitim işlemlerinin gerekliliği ve önemi gibi konularda bilinç düzeyini arttırmak için devlet kurumları, dernekler, topluluklar ve diğer gönüllü kuruluşların iş birliği içerisinde çalışmaları konusunda öneriler getirilmiştir. From the begining of the human life people used clothes to protect themselves from nature, but later on clothing has gained a meaning of behaviour which they used it to express themselves in the society.When the history of clothing is studied, it may easily be seen that it was not only important for adults, it was important for the children too. The importance of clothing may be seen from some paintings of the famous painters.As it?s said before; as similiar with the adults for children, clothing is a kind of way for expressing themselves. Choosing their clothes according to their characters is extremely important for their physicological and sociological growth. This can be only possible when they become at a certain age. Before that age for instance at the ages between zero and two babies don?t have the ability of choosing their own clothes, for this reason their mothers make the preference and purchase.The years between zero and two are the most important years in babies growing up period. Most of the differences occurs in these years, for example the baby gains walking ability from laying position, because of all these changes, range of garment types spreads more than the other years. At this point the bigger responsibility belongs to the babies clothing producers. Producers have to carry out a great and realistic market analysis. Knowing and understanding the mothers demand on their babies clothes is extremely important for the manufacturers inside the sector. This study is prepared to understand the mothers demand on their zero and two year old babies clothing and to be a source for the further studies on similar subjects. We hope that this study will be agood source for the babies clothing sector as a kind of market search as well. Keywords; babies clothing, organic textile, ecological textile, textile finishing processes During the research, at the data collection period some questions are asked to the 0-2 year old baby owned mothers about whether they give importance to their babies clothes external properties like its model, its colour, its printings...etc., or they give importance to being stain proofness, anticrease, quick dry, functionality, ergonomy..etc. or they give importance to being antibacterial, produced from natural fibers, famous branded, at reachable price... etc.This research has done in the capital city Ankara. In order to reach the sample group easily, the volunteers is chosen from the children?s hospitals and preschools in Çankaya. The sample group is composed of 250 volunteer mothers who are chosen randomly.The results are generalised to the mothers who live in the town Çankaya, in Ankara. The research universe is composed of the 0-2 year old baby owned mothers in town Çankaya in Ankara. The data giver volunteers are choosen from Çankaya because the people who live in this town are more educated and their purchasing behaviour is more than the other towns. This research is trying to determine a consumer behaviour so that the people in Çankaya town are thought as more conscious and have more purchasing frequency.The data collected from the research is analysed by a statistical package programme called E-views. The demographic features of the sample group is given by frequency tables. For the results of the research, the percentage and frequency distributions of the data are obtained and in order to find out whether there is a statistical relationship between the demographic features of the sample group and the other questions by cross tables.At the end of the study, it is determined that mothers prefer finishing operations which provide easy usage. Even they prefer their babies clothes organic, they haven?t got enough information about organic textile certificates and ökotex certificate. The mothers don?t give enough attention to buying garments produced by natural fibres. And finally it is determined that the mothers don?t have enough knowledge about harmful prints and dyes.Some suggestions are proposed to raise the consciousness level of 0-2 year old baby owner mothers about organic textile, ökotex certificate and certification in garments, the necessity of finishing operations, harmful chemicals in textile. The awareness about all these topics may be provided by the co-operation with legal agents, social associations, consumer unions.
- Published
- 2013
42. SAHNE VE GÖSTERİ SANATLARINDA SANAT TASARIM VE TEKNOLOJİ EĞİTİMİ SAHNE TEKNİSYENLİĞİ EĞİTİMİ
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AYDIN, SEMİHA and ORAL, GÜLŞİN
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- 2011
43. The Effect of in-Service Training Given in Ready-Made Clothing Sector on Views of the Employees Regarding Quality
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ŞAHİNOĞLU, Meyrem Arga, primary and AYDIN, Semiha, additional
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- 2015
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44. Moda tasarımı eğitiminde tasarımların değerlendirilmesine yönelik bir ölçme aracı geliştirme
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AYDIN, SEMİHA
- Abstract
Moda tasarımı alanında yükseköğretim kurumları, lisans programları ile moda giyim sektörünün ihtiyaç duyduğu, moda tasarımcılarını yetiştirmeyi hedeflemektedir. Eğitimde, mevcut uygulamaların hedeflere ulaşmada etkililiğinin, öğrencilerde istendik davranışların gerçekleşip gerçekleşmediğinin, gerçekleşti ise ne derecede gerçekleştiğinin belirlenmesi, varsa sorunların belirlenerek çözümlenmesi, başarıların ise güdülenmesi ve geliştirilerek sürdürülmesi, etkili bir ölçme ve değerlendirmeyi gerektirmektedir. Tasarımın ve dolayısı ile tasarım eğitiminin, anlaşılması en güç kavramlardan birisi olan yaratıcılık üzerine temellenmesi; tasarım problemlerinin fikir, çizim ya da ürün olarak sonsuz sayıda doğru cevabının oluşu; bu doğru cevapları üretmede çok boyutlu becerilerin bir arada kullanılması gereği, ölçme ve değerlendirmeyi güçleştirmektedir. Çok boyutlu, karmaşık becerilere dayanan tasarım performansının, kağıt kalem testleri olarak adlandırılan ölçme yaklaşımları ile ölçülmesi olanaksızdır. Bu durum, tasarım eğitiminde ölçmeyi, alternatif ölçme yöntemi olan performans ölçmenin konusu haline getirmektedir. Performans ölçmede en çok kullanılan ölçme araçları ise rubric/dereceleme ölçekleri, puan kartı ya da kontrol listesidir. Tasarım eğitiminde stüdyo dersleri, tasarım problemlerini çözmede öğrencilerin, tasarım ile ilgili öğrendikleri tüm bilgi ve becerileri bir arada kullanmaları gereken, tasarım programlarının sentez dersleridir. Son sınıf stüdyo dersleri ise öğrenim düzeyinin en yüksek olduğu, dolayısı ile tasarım problemlerini çözmede, öğrencilerin performanslarını en yüksek düzeyde göstermelerinin beklendiği derslerdir. Bu derslerin final sınavları (dönem sonu sınavları), tasarım sürecinin tamamlandığı ve öğrencilerin tasarıma yönelik performanslarının bir bütün olarak ölçüldüğü sınavlardır. Final sınavlarında, en önemli performans boyutları ise iki ve üç boyutlu ürünlerdir. Bu doğrultuda, bu araştırmanın temel amacını, moda tasarımı eğitimi veren yükseköğretim kurumlarında, performans ölçme araçları, ölçütler ve ölçme yaklaşımlarının belirlenmesi; moda tasarımı eğitiminin, son sınıf stüdyo derslerinde, öğrenci performansının önemli boyutlardan bir tanesi olan tasarımları, ölçme ve değerlendirmede bir ölçme aracının geliştirilmesi oluşturmuştur. Bu araştırma, amaca ulaşmada izlenen yol ve yeni bir ölçme aracı önermesi ile bir Eylem Araştırmasıdır. Araştırma örneklemini, Türkiye'de bulunan ve ölçüt örneklem yöntemi ile belirlenen, altı üniversitede görev yapan 22 öğretim elemanı ve ölçme aracı niteliklerini belirleme çalışmalarına katılan son sınıf stüdyo dersi öğrencileri oluşturmaktadır. Araştırma verilerinin elde edilmesinde, nicel ve nitel veri toplama teknikleri bir arada kullanılmıştır. Araştırmanın nicel verilerinin çözümlenmesinde istatistiksel analiz yöntemleri, nitel verilerin çözümlenmesinde ise içerik analizi yöntemi uygulanmıştır. Moda tasarımı eğitiminin stüdyo derslerinde, ölçme yaklaşımı olarak daha çok jürili yaklaşımın benimsendiği; final sınavının en önemli performans boyutunu iki ve üç boyutlu ürünlerin oluşturduğu; üç boyutlu ürünlere yönelik performans ölçütlerinin, yaratıcılık temel ölçütü altında, özgünlük, yenilik-farklılık, temaya uygunluk, hedef kitleye uygunluk, estetik, fonksiyonellik, üretim kalitesi, koleksiyon mantığına uygunluk, endüstri üretimine uygunluk olduğu, araştırma bulguları doğrultusunda ulaşılan sonuçlardan bazılarıdır. Ayrıca, geliştirilen ölçme aracı uygulanarak, güvenirlik, geçerlik ve kullanışlılık nitelikleri test edilmiştir. Bu testler sonucunda aracın, kabul edilebilir niteliklere sahip olduğu belirlenmiştir. Universities offering graduate degrees with fashion design curriculum training the fashion designers needed by the fashion clothing sector. Determination of the efficacy of existing practices in education in reaching the targets, whether or not the desired changes have occurred in the students and the level of change, identification and solution of problems if any, and motivation, improvement and sustaining the achievements require an effective measurement and review. That design and thus design education is based on creativity, one of the most difficult concepts to understand; that design problems have infinite number of accurate answers in the form of ideas, drawings or products, and the requirement to use multidimensional skills in identifying these accurate answers together make measurement and assessment harder. It is not possible to measure design performance which requires multidimensional and sophisticated skills by classical measurement approaches, also named as pencil/paper tests. This makes measurement the subject of performance measurement, an alternative measurement method, in design education. Rubric/grading scales, score cards or checklists are the most used measurement tools in performance measurement. In design education, studio courses are course synthesizing design programs, where the students are required to use the design-related knowledge and skills they have acquired in solving design problems together. And the studio courses during the final year of the study offer the highest level of learning, thus are the courses students are expected to demonstrate their performance at the highest level in solving the design problem/problems. Final exams (end-of-semester exams) of these courses are exams where the design process is completed and students' performance aimed at design is measured as a whole. The most important performance outcomes in the final exams are two-dimensional and three-dimensional products. In this context, the fundamental purpose of this study have been the identification of performance assessment tools, criteria and assessment approaches in colleges offering fashion design education, and the development of a assessment tool in assessing and evaluating the designs, which are an important dimension of student performance in final year studio courses. This study is a case study in its objective, methods followed in reaching that objective and recommendation of a new measurement tool. The study samples consist of 22 lecturers and last year students who attended works of assessment of measurement toll, chosen by criterion sampling method, working in six universities in Turkey. Quantitative and qualitative data gathering techniques were used together in obtaining the study data. Statistical analysis methods were applied in analyzing the quantitative data, and content analysis method was applied in analyzing the qualitative data of the study. In the fashion design education studio courses, some of the results found in line with the study findings are that the jury approach is mostly adopted as a assessment approach; two-dimensional and three-dimensional products consisted of the most important performance dimension of the final exam; performance criteria aimed at three-dimensional products were originality, innovation-distinction, suitability with the theme, suitability for the target group, aesthetic, functionality, production quality, consistency with the logic of collection, suitability for industrial production under the fundamental criteria of creativity. Reliability, validity and usefulness qualities were also tested applying the devised measurement tool. As a result of these tests, it was found that it had acceptable qualities.
- Published
- 2010
45. HAZIR GİYİM SEKTÖRÜNDE ÜRETİM HATALARININ GİDERİLMESİNE YÖNELİK BİR HİZMETİÇİ EĞİTİM PROGRAMI GELİŞTİRME
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AYDIN, SEMİHA
- Abstract
Dünyadaki bütün işletmeler çetin rekabet şartlarına direnebilmek ve varlıklarını sürdürebilmek için kaliteyi artırmaya yönelik çalışmalar yapmaktadır. Kaliteli ürünler üretebilmek için işgörenlerin sistemli, yoğun ve hedeflere yönelik olarak eğitilmeleri gerekmektedir. Hazır giyim sektöründe de, yetişmiş eleman ile üretimin kalitesi arasında sıkı bir ilişki mevcuttur. Üretimin her aşamasında istihdam edilen kişilerin eğitim düzeyi arttığı ölçüde üretilen ürünün kalitesi ve sektörün uluslararası piyasalarda ki başarısı giderek artmaktadır Araştırmanın amacı; Deniz Kuvvetleri Komutanlığı'na bağlı Deniz Dikimevi'nde eğitim elbisesi üretiminde karşılaşılan üretim hatalarını belirleyerek, bu hataları gidermeye yönelik bir hizmet içi eğitim programı hazırlamak ve bu programı işgörenlere uygulayarak eğitimin üretim hataları ve işgörenlerin kaliteye ilişkin görüşleri üzerindeki etkilerini belirlemektir. Araştırmada, nedensel karşılaştırma yöntemi kullanılmıştır. Eğitim elbisesi üretiminde yapılan hataların belirlenmesi amacıyla, araştırma grubunun üretmiş olduğu eğitim elbiseleri gözleme tabi tutulmuştur. Gözlemler sonucunda, işgörenlerin eğitim elbisesi üretiminde en çok yaptıkları hatalar belirlenmiş ve bu hataları gidermeye yönelik bir hizmet içi eğitim programı hazırlanmıştır. Hizmet içi eğitim programı hazırlanırken işgörenlerin eğitim elbisesinin üretimi sırasında yaptıkları hatalar (% 5' in üzerindeki hatalar) esas alınmıştır. Hazırlanan eğitim programı işgörenlere uygulanmış ve eğitim sonrasında yapılan hatalarda azalma olup olmadığını belirlemek amacıyla üretilen eğitim elbiseleri tekrar gözleme tabi tutulmuştur. Deniz Dikimevinde üretilen eğitim elbisesinde yapılan üretim hatalarını belirlemek amacıyla Günlük Kontrol Tabloları hazırlamıştır. Kontrol tabloları hazırlanmadan önce Dikimevinde gözlemler yapılmış, yapılan gözlemler sonucu eğitim elbisesinin süreç analizi hazırlanmış ve kontrol noktaları belirlenmiştir. Her bir kontrol noktası tek tek ele alınarak kalite parametreleri belirlenmiştir. Belirlenen kontrol notaları ve kalite parametrelerine bağlı olarak Günlük Kontrol Tabloları oluşturulmuştur. Ayrıca işgörenlerin kaliteye ilişkin görüşlerini belirlemek amacıyla anket hazırlanmıştır. Hazırlanan anket, eğitim öncesi ve sonrası işgörenlere uygulanmıştır. Eğitim sonucunda, yapılan hatalarda öntest ve sontest arasında ilişki olup olmadığını belirlemek amacıyla (X²) Ki Kare analizi yapılmış, sonuçlar p
- Published
- 2010
46. TEDARİK ZİNCİRİ YÖNETİMİNDE BİLGİ SİSTEMLERİ VE DERİ HAZIR GİYİM SEKTÖRÜNE BİR YAZILIM ÖNERİSİ
- Author
-
AYDIN, SEMİHA
- Abstract
Günümüzde birçok işletme, rekabet üstünlüğü elde etmede işletmeler arası ilişkilerin önemini anlamış ve yeniden yapılandırmaya önem vermeye başlamışlardır. Bu yapılandırma sürecinde Tedarik Zinciri Yönetimi önemli bir yere sahiptir. Tedarik zinciri yönetimi; tedarikçilerden son kullanıcıya kadar malzeme akışının kontrolü ve planlanmasıyla ilgili bütünleşmiş bir yaklaşımdır. Tedarik Zinciri Yönetimiyle, işletmelerde hizmet düzeyinin ve kalitesinin artırılması, verimlilik ve hızın artırılması, malzeme/stok kayıtlarında kontrol düzeyinin yükseltilmesi, müşteri beklentilerinin zamanında ve doğru olarak karşılanması sağlanır. Bu araştırmada; deri hazır giyim işletmesinin, hammadde ve yardımcı malzeme deposu bilgilerinin bütünleşik bir veri/bilgi sistemi desteğiyle yönetilmesini, tedarikçi ve müşteri zincirini tamamlayan, aynı zamanda stokların kontrolünü sağlayan bir yazılım oluşturmak hedeflenmiştir. Araştırmada, betimsel araştırma yönteminden 'Vak'a İncelemesi' uygulanmıştır. İzmir'de Ege Deri Sanayicileri Derneğine kayıtlı orta ölçekli bir deri hazır giyim işletmesi örneklem olarak seçilmiştir. Depo yazılımı için gerekli verilerin toplanmasında yapılandırılmamış görüşme formu kullanılmıştır. Görüşme formu ile elde edilen bulgular doğrultusunda yazılım modeli hazırlanmıştır. Yazılımın hazırlanmasında Visual Studio Net ve Access veri tabanı kullanılmıştır. Yazılımın görsel tasarımına karar verilebilmek için taslak program hazırlanmıştır. Taslak olarak hazırlanan program, uzman ve işletme yetkilisi ii görüşleri doğrultusunda yeniden yapılandırılmıştır. Hazırlanan yazılım sayesinde işletme, hem tedarikçi hem de müşteri bilgilerini oluşturabilecek, tedarikçiden gelen malzemelerin giriş ve kullanılan malzemenin çıkış işlemlerini yapabilecek, tüm malzemelerin stok bilgilerine kolaylıkla ulaşılabilecektir. Ayrıca; giriş ve çıkış işlemi yapılan tüm malzemelerin stok hareketlerini, stok raporlarını gün, ay ve yıl olarak da takip edebilmektedir. A işletmesi; hazırlanan depo yazılımıyla, aldığı bilgi teknolojileri desteğiyle mevcuda göre çok daha hızlı ve doğru stok bilgilerine ulaşabilecektir. Böylece; işletmenin yıllık depo sayımlarında meydana gelen işgücü kayıplarını, hız kayıplarını, stok raporlarının oluşturmada ve doğru bilgiye ulaşmadaki bekleme sürelerini ortadan kaldırarak verimliliğinin artmasında katkı sağlayacağı bir model önerilmiştir.
- Published
- 2010
47. 3-(1,1-diokso-2h-(1,2,4)-benzotiyodiazin-3-il)-4-hidroksi-2(1h)-kinolin bileşik serisinin hepatit c inhibitörü olarak elektron konformasyon-genetik algoritma (EC-GA) yöntemi ile QSAR incelenmesi
- Author
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Aydin, Semiha, Sarıpınar, Emin, and Kimya Anabilim Dalı
- Subjects
Chemistry ,Genetic algorithms ,Hepatitis C ,Kimya - Abstract
Bu çalışmada 3-(1,1-Diokso-2H-(1,2,4)-Benzotiyodiazin-3-il)-4-Hidroksi-2(1H)-Kinolin bileşik serisinin Elektron Konformasyon Genetik Algoritma (EC-GA) yöntemi ile QSAR incelemesi yapılmıştır. Seride deneysel aktivitesi bilinen 111 bileşik için kuantum kimyasal hesaplamalar HF-3-21G metodu kullanılarak kantitatif aktivite hesaplanmış ve farmakofor (Pha) grup tanımlaması yapılmıştır. Elektron Konformasyonel Uygunluk Matrisleri (ECMC), bileşiklerin elektronik yapı hesaplamaları ve konformasyon analiz bilgilerinden faydalanılarak EMRE programı ile hazırlanmıştır. ECMC ler Pha grubu temsil eden ve aktif bileşiklerin hepsinde aynı olan Elektron Konformasyonel Alt Matrisi (ECSA) bulmak için karşılaştırılır. Moleküler parametreler serideki bütün bileşiklerin her bir konformeri için çalışma grubumuz tarafından geliştirilen EMRE programı ile hazırlandı ve bu parametreler, aktiviteyi hesaplamak için Genetik Algoritma Optimizasyon Tekniğinde kullanıldı. Biyolojik aktivite hesaplaması için 1064 parametre hazırlandı. Ancak bu moleküler parametrelerin hepsi aktivite hesaplaması için önemli değildir. Bu parametrelerin önemli olanlarını seçmek ve aktivitelerine karar vermek için genetik algoritma optimizasyon tekniği ve en küçük kareler yöntemi kullanılmıştır. Kinolin serisinde yer alan 111 bileşik, eğitim (90 bileşik) ve test seti (21 bileşik) olmak üzere iki gruba ayrılmıştır. Deneysel ve hesaplanan aktivite arasındaki regresyon katsayısı, r2, eğitim seti için 0.7395, test seti için 0.9019 olarak hesaplanmıştır. Leave One Out Cross Validation (LOOCV) yöntemi ile hesaplanan modelin geçerlilik katsayısı, q2, değeri 0.6387 bulunmuştur. We present in this study the results of pharmacophore (Pha) identification and quantitative Hepatitis C activity prediction for the class of 3-(1,1-Dioxo-2H-(1,2,4)-Benzothiadiazine-3-yl)-4-Hydroxy-2(1H)-Quinoline using the Electron Confomation-Genetic Algorithm (EC-GA) method. At first, conformational analysis and electronic structure calculation of each of the molecules in the compound series are performed by HF-3-21G method. The Electron Conformational Matrices of Congruity (ECMCs) are constructed from the data of conformational analysis and electronic structure calculation of each molecules in the compound series by EMRE programme. Later, the ECMC is processed by means of a special program of matrix comparisons (ECSP) in order to reveal the Electron Conformational Submatrix of Activity (ECSA), which represent the Pha, same for all the active compounds. The molecular descriptors of every conformer of the compounds are performed with EMRE which is prepared by us and these descriptors are used in Genetic Algorithm Optimization Tecnique (GA) for calculating the activity. Every conformer of each compound is described by 1064 are molecular descriptors available for predicting biological activity. To select the important variables for describing the inhibition activities, the variable selection method using GA and nonlinear least square regression methods (lsqnonlin) were applied. In addition to this calculation, the compound series divided into training set and testing set. Using the molecular descriptor values found biological activity of the test set are determined. The correlation coffecient, between estimated activity and experimentally measured activity, r2 values, obtained are 0.7395 and 0.9019 for the training and testing sets, respectively. 139
- Published
- 2010
48. PERFORMANS YÖNETİM ARACI OLARAK BALANCED SCORECARD SİSTEMİNİN HAZIR GİYİM İŞLETMESİNDE UYGULANMASI VE BİR MODEL GELİŞTİRME
- Author
-
AYDIN, SEMİHA
- Abstract
Bilim, teknoloji, iletişim alanlarında yaşanan hızlı değişim sonucunda stratejik hedeflerle yol almak zorunda kalan hazır giyim sektörü, mevcut pazar koşulları, insan kaynağına dayanan gücü, üretim yapısı nedeniyle karmaşık ve dinamiktir. Maddi varlığı olmayan değerlerin önem kazandığı rekabet koşullarında hazır giyim işletmeleri, somut ve soyut varlıklardan oluşan yapılarını ölçümleyecek performans değerlendirme yaklaşımlarına daha fazla ihtiyaç duymaktadır. Balanced Scorecard örgütlerin stratejisini belirlemesini, bu stratejiyi amaçlar, ölçütler, hedefler ile uygulanabilir adımlara dönüştürmesini ve etkin şekilde uygulanmasını sağlayan çok boyutlu performans yönetim sistemlerinden birisidir. Bu araştırma, değişen pazar koşullarında rekabet üstünlüğü kazanmak isteyen hazır giyim işletmesinde çok boyutlu bir performans ölçüm modeli oluşturmak amacı ile hazırlanmıştır. Nitel özelliğe sahip araştırmada teknik / bilimsel / katılımcı eylem araştırması yöntemi kullanılmıştır. Çalışmanın örneklemini, Ankara'da faaliyet gösteren ve sisteme olumlu yaklaşan bir hazır giyim işletmesi oluşturmaktadır. Veriler yapılandırılmamış görüşme, gözlem, doküman incelemesi, anket ve beyin fırtınası teknikleri kullanılarak elde edilmiştir. Uygulamanın gerçekleştirildiği hazır giyim işletmesinin geleneksel yapıdaki finansal performans anlayışı, Balanced Scorecard sistem yaklaşımıyla stratejik performans yönetim sistemine dönüştürülmüştür. İşletme yapısı SWOT analizi ile değerlendirilerek misyon, vizyon ve strateji yapılandırılmıştır. Çalışanların görev tanımları oluşturulduktan sonra kritik başarı faktörleri belirlenmiştir. Vizyon ve stratejiye ulaşmak için müşteri, iç süreçler, finansal, öğrenme ve gelişme boyutları kapsamında amaçlar, ölçütler ve hedefler oluşturulmuştur. İşletme için belirlenen amaç ve hedeflerin gerçekleştirilmesine yönelik girişimlerde bulunulmuştur. Kurumsal açıdan işletmenin ve bölümlerin performansları ölçülerek değerlendirmeye alınmıştır. On beş aylık uygulama süresince üç ayda bir olmak üzere beş ölçüm dönemi gerçekleştirilmiştir. Hazır giyim işletmesi için oluşturulan Balanced Scorecard modeli kapsamında, kurum ve bölümler düzeyinde üretim hızı, model çeşidi, kârlılık, verimlilik, müşteri ilişkileri, müşteri ve çalışan memnuniyetleri amaçlarında hedeflere, aynı zamanda stratejiye yönelik başarılı performans artışlarının sağlandığı sonucuna varılmıştır. Apparel sector that is forced to proceed with strategic targets as a result of the rapid changes in science, technology and communications is complicated and dynamic due to its human-resource-dependent power, production structure and existing market conditions. Under market conditions where intangible assets gain importance, apparel enterprises need performance evaluation approaches more than ever to measure their structures consisting of tangible and intangible assets. Balanced Scorecard is one of the multidimensional performance management systems that allow organizations to determine their strategy, turn it into applicable steps with objectives, measures, targets and implement it efficiently. This study has been prepared with the purpose of building a multi-dimensional performance measurement model for the apparel enterprise that aspire to gain competitive advantage under changing market conditions. Technical / scientific / participatory action research method is adopted in the study that is characterized as qualitative. The sampling of the study consists of an apparel enterprise that operates in Ankara and has a favourable stance towards the system. The data are obtained through the techniques of unstructured interview, observation, document survey, questionnaire and brainstorming. The traditional financial performance mentality in the apparel enterprise in question has been converted into strategic performance management system by means of Balanced Scorecard system approach. The enterprise structure has been analyzed with SWOT analysis to structure mission, vision and strategy. After defining the tasks of employees, critical success factors have been established. Goals, criterias and targets have been determined within the scope of customer, internal processes, financial, learning and development dimensions in order to achieve the vision and strategy. Initiatives have been spent to fulfil the goals and targets determined for the enterprise. In corporate terms, performance of the enterprise and the departments has been measured and assessed. During fifteen-month application, five measurement periods have been performed as per quarter. Within the scope of the Balanced Scorecard model established for the apparel enterprise, it has been concluded that performance increases have been achieved at corporate and departmental level in the strategy as well as the goals and targets in production rate, model variety, profitability, productivity, customer relationships, and customer and employee satisfaction.
- Published
- 2010
49. Telestia Metoduna Göre Hazırlanan Temel Beden Kalıplarının Telestia metoduna göre hazırlanan temel beden kalıplarının Sinop ilinde yaşayan 18-35 yaş arası kadınların beden yapısına uyumu üzerine bir araştırma
- Author
-
AYDIN, SEMİHA
- Abstract
İyi giyinmek ve beğenilme arzusu giyimin önemini vurgularken mükemmel giyimin tamamlayıcı ve en önemli unsurunu da kalıp oluşturmaktadır. Vücuda uygun kalıpların hazırlanmasında bazı kuralların öncelikle saptanması gerekmektedir. Kalıp hazırlamanın en önemli koşulu ise sağlıklı ve kullanılacak sisteme uygun ölçü almaktır. İyi bir ölçü almak için öncelikle vücut tiplerini, oranlarını ve ölçüsü alınacak kişinin vücut yapısını ve özelliklerini iyi incelemek gerekmektedir. Önemli olan ise ölçü standardının olması ve bu standardın o toplumun özelliklerini yansıtması gerekmektedir. Tasarım ve kalıpların hazırlanması aşamasında unutulmaması gereken en önemli konu insan vücudunun yapısıdır. Bir giysinin vücuda uygunluğu hazırlanan beden kalıplarının vücut özelliklerine göre hazırlanmasına bağlıdır. Vücut yapısı kişiden kişiye farklılık göstermektedir. Vücut özellikleri dikkate alınarak hazırlanan kalıplarla elde edilen giysilerin vücut ile tam bir uyum içerisinde olması kaçınılmaz bir sonuçtur. Kadın giyiminde; temel kalıp sisteminin yetersizliği, her firmanın kendi kalıbını kendi ölçülerine göre çıkarması, iki farklı firma arasında, aynı bedenler arasında büyük farklar oluşmasına neden olmaktadır. Bunun sonucu ise ürünlerin halka sunumu sırasında mağaza içi terzi hizmetleri gündeme gelmektedir. Bu durumun emek, zaman ve kalitede sorunlara yol açtığı düşünülürse temel kalıbın ne kadar önemli olduğu ortaya çıkmaktadır. Giyim endüstrisindeki temel amaç, üretilen giysilerin geniş bir kitleye hitap edecek şekilde tasarlanması ve üretilmesidir. Bu da ancak Türk kadınının vücut yapısına ve tiplerine uygun beden ölçüleri ile hazırlanmış kalıplarla mümkün olacaktır. Bu araştırmanın temel amacı; Telestia metoduna göre hazırlanan temel beden kalıplarının Sinop ilinde yaşayan 18-35 yaş arası kadınların beden yapısına uyumunu inceleyerek, araştırmada elde edilen veriler sonucunda uyum problemi görülen yerleri belirlemek ve çözüm önerileri geliştirmektir. Araştırmanın evrenini Sinop ilinde yaşayan 18-35 yaş arasındaki kadınlar oluşturmaktadır. Örneklem grubunu evrenden random yolla seçilen 125 Türk kadını oluşturmaktadır. Araştırma verilerinin toplanmasında genel bir tablo hazırlanmış bu tabloda örneklem grubunun kişisel özellikleri (isim, yaş ve doğum yeri ) ve örneklem grubunu oluşturan 125 kişi üzerinden Telestia metoduna uygun olarak alınan ölçülere yer verilmiştir. Telestia metoduna uygun olarak hazırlanan temel beden kalıplarının uyum durumunu tespit etmek için gözlem formları geliştirilmiştir. Her kalıp özelliği için ayrı tablolar oluşturulmuş ve genel tablodan özele doğru gidilmiştir. Örneklem grubunu oluşturan her birey için birebir ölçülerde temel beden ve temel kol kalıpları hazırlanarak Amerikan kumaşla tüm beden olarak dikilmiştir. Dikilen bu giysiler örneklem grubuna giydirilmiştir. Giysilerdeki uyum durumu oluşturulan gözlem formlarına aktarılmıştır. Örneklem grubu üzerinden elde edilen verilerin istatistikî analizleri SPSS 16.0 programı ile yapılarak bulgular tablolar halinde sunulmuştur. Araştırmanın birinci bölümünde; problem durumu, araştırmanın amacı, önemi, problem cümlesi, alt problemler, sayıltılar, sınırlılıklar ve tanımlara yer verilmiştir. İkinci bölümde; kuramsal çerçevede, anatomik özellikler, vücut oranları, vücut tipleri ve duruşlarına değinilmiştir. Giyimin tanımı ve tarihçesi, ergonomik ve antropometrik açıdan kalıbın tanımı, önemi, kalıp hazırlamada dikkat edilecek noktalar ve kalıp hazırlama tekniklerine yer verilmiştir. Telestia Metodu hakkında bilgi verilirken, metoda göre kadın vücut oranları, kullanılan gereçler, ölçü alma teknikleri, pensli beden kalıbı çizimi ve temel kol çizimi anlatılmıştır. İlgili araştırmalar bölümünde ise bu konu ile ilgili olarak yapılan araştırmalara yer verilmiştir. Araştırmanın üçüncü bölümünde de materyal, yöntem açıklanmış, veri toplama araçları ve veri analizlerine yönelik bilgiler verilmiştir. Araştırmanın dördüncü bölümünde bulgular ve yorumlarda araştırma sonuçları tablolar halinde sunulmuştur. Araştırma sonucunda elde edilen verilere göre Telestia Metodu ile hazırlanan kadın temel beden kalıplarının araştırmanın örneklem grubunu oluşturan 125 Türk kadınına büyük ölçüde uyum sağladığı görülmüştür. Bulguların tartışılmasıyla teze yönelik öneriler geliştirilmiştir. Araştırma raporunda bu bölümü Kaynakça ve Ekler bölümleri takip etmektedir.
- Published
- 2010
50. Information Systems in Supply Chain Management and a Software Proposal for Leather
- Author
-
KAHYA, Saliha Özelmas, primary and AYDIN, Semiha, additional
- Published
- 2014
- Full Text
- View/download PDF
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