Search

Your search keyword '"Ayala, Oscar D."' showing total 11 results
Start Over Author "Ayala, Oscar D."
11 results on '"Ayala, Oscar D."'

3. Correction to “Multimodal Multiplexed Immunoimaging with Nanostars to Detect Multiple Immunomarkers and Monitor Response to Immunotherapies”

Author

Ou, Yu-Chuan, primary, Wen, Xiaona, additional, Johnson, Christopher A., additional, Shae, Daniel, additional, Ayala, Oscar D., additional, Webb, Joseph A., additional, Lin, Eugene C., additional, DeLapp, Rossane C., additional, Boyd, Kelli L., additional, Richmond, Ann, additional, Mahadevan-Jansen, Anita, additional, Rafat, Marjan, additional, Wilson, John T., additional, Balko, Justin M., additional, Tantawy, Mohammed N., additional, Vilgelm, Anna E., additional, and Bardhan, Rizia, additional

Published
2020
Full Text
View/download PDF

4. Multimodal Multiplexed Immunoimaging with Nanostars to Detect Multiple Immunomarkers and Monitor Response to Immunotherapies

Author

Ou, Yu-Chuan, primary, Wen, Xiaona, additional, Johnson, Christopher A., additional, Shae, Daniel, additional, Ayala, Oscar D., additional, Webb, Joseph A., additional, Lin, Eugene C., additional, DeLapp, Rossane C., additional, Boyd, Kelli L., additional, Richmond, Ann, additional, Mahadevan-Jansen, Anita, additional, Rafat, Marjan, additional, Wilson, John T., additional, Balko, Justin M., additional, Tantawy, Mohammed N., additional, Vilgelm, Anna E., additional, and Bardhan, Rizia, additional

Published
2019
Full Text
View/download PDF

9. Multimodal Multiplexed Immunoimaging with Nanostars to Detect Multiple Immunomarkers and Monitor Response to Immunotherapies

Author

Ou, Yu-Chuan, Wen, Xiaona, Johnson, Christopher A., Shae, Daniel, Ayala, Oscar D., Webb, Joseph A., Lin, Eugene C., DeLapp, Rossane C., Boyd, Kelli L., Richmond, Ann, Mahadevan-Jansen, Anita, Rafat, Marjan, Wilson, John T., Balko, Justin M., Tantawy, Mohammed N., Vilgelm, Anna E., and Bardhan, Rizia

Abstract

The overexpression of immunomarker programmed cell death protein 1 (PD-1) and engagement of PD-1 to its ligand, PD-L1, are involved in the functional impairment of cluster of differentiation 8+(CD8+) T cells, contributing to cancer progression. However, heterogeneities in PD-L1 expression and variabilities in biopsy-based assays render current approaches inaccurate in predicting PD-L1 status. Therefore, PD-L1 screening alone is not predictive of patient response to treatment, which motivates us to simultaneously detect multiple immunomarkers engaged in immune modulation. Here, we have developed multimodal probes, immunoactive gold nanostars (IGNs), that accurately detect PD-L1+tumor cells and CD8+T cells simultaneously in vivo, surpassing the limitations of current immunoimaging techniques. IGNs integrate the whole-body imaging of positron emission tomography with high sensitivity and multiplexing of Raman spectroscopy, enabling the dynamic tracking of both immunomarkers. IGNs also monitor response to immunotherapies in mice treated with combinatorial PD-L1 and CD137 agonists and distinguish responders from those nonresponsive to treatment. Our results showed a multifunctional nanoscale probe with capabilities that cannot be achieved with either modality alone, allowing multiplexed immunologic tumor profiling critical for predicting early response to immunotherapies.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results