1. The Effects of Interleukin-6 and Cytokine-Induced Neutrophil Chemoattractant-1 on .ALPHA.2-Macroglobulin Production in Rats
- Author
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Shunsuke Yamazaki, Ayaka Yamaga, Shizuo Yamamoto, Toshio Honjo, Yui Mokonuma, Takashi Kuribayashi, and Tetsurou Seita
- Subjects
medicine.medical_specialty ,General Veterinary ,biology ,Chemistry ,medicine.medical_treatment ,Chemotaxis ,General Medicine ,Normal serum ,General Biochemistry, Genetics and Molecular Biology ,Macroglobulin ,Sexual dimorphism ,Sprague dawley ,Endocrinology ,Cytokine ,Sex factors ,Internal medicine ,Immunology ,medicine ,biology.protein ,Animal Science and Zoology ,Interleukin 6 - Abstract
We investigated the effects of interleukin-6 (IL-6) and cytokine-induced neutrophil chemoattractant-1 (CINC-1) on α(2)-macroglobulin (α2M) production in rats. IL-6-rich and CINC-1-rich fractions were separated from serum obtained from rats 12 h after injection with turpentine oil using gel-chromatography. Sexual dimorphism was observed in the peak levels of α2M after injection of IL-6-, CINC-1-, or a mixture of IL-6-and-CINC-1-rich fractions. No significant differences in α2M levels were observed in males after injection with IL-6- or CINC-1-rich fractions and those injected with normal serum obtained from healthy rats (control). In contrast, serum levels of α2M, 6 to 120 h after injection of a mixture of IL-6- and CINC-1-rich fractions were significantly higher than in control rats. These results suggest that IL-6 and CINC-1 contribute to α2M production in rats only when IL-6 and CINC-1 act synergistically.
- Published
- 2010
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