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7 results on '"Ayşe Destina Yalçın"'

1. Diagnosis of comorbid migraine without aura in patients with idiopathic/genetic epilepsy based on the gray zone approach to the International Classification of Headache Disorders 3 criteria

Author

Arife Çimen Atalar, Aynur Özge, Bengi Gül Türk, Esme Ekizoğlu, Duygu Kurt Gök, Betül Baykan, Semih Ayta, Füsun Ferda Erdoğan, Seher Naz Yeni, Bahar Taşdelen, IDEM Study Group, Sibel K. Velioğlu, Zuhal Yapıcı, İpek Midi, Saygı Serap, Çelebi Ulufer, Elif Sarıca Darol, Kadriye Ağan, Senem Ayç, Sibel Gazioğlu, Zeynep Vildan Okudan, Nermin Görkem Şirin, Nerses Bebek, Neşe Dericioğlu, İlknur Güçlü Altun, Ayşe Destina Yalçın, Reyhan Sürmeli, Oğuz Osman Erdinç, Abidin Erdal, Demet İlhan Algın, Gülnihal Kutlu, Semai Bek, Yüksel Erdal, Akçay Övünç Özön, Aylin Reyhani, Babürhan Güldiken, Barış Baklan, Bülent Oğuz Genç, Ebru Aykutlu Altindağ, Gökçen Karahan, Güray Koç, Handan Mısırlı, İbrahim Öztura, Kezban Aslan-Kara, Melodi Çakar Merve, Nur Türkmen, Onur Bulut, Karadaş Ömer, Özlem Kesim Çahin, Sevgi Ferik, Taylan Peköz Mehmet, Pınar Topaloğlu, Sibel Üstün Özek, Ülkühan Düzgün, Vildan Yayla, Yasemin Gömceli, and Zeynep Ünlüsoy Acar

Subjects
migraine, idiopathic epilepsy, classification tree, headache, headache criteria, migraine without aura, Neurology. Diseases of the nervous system, RC346-429
Abstract

BackgroundMigraine without aura (MwoA) is a very frequent and remarkable comorbidity in patients with idiopathic/genetic epilepsy (I/GE). Frequently in clinical practice, diagnosis of MwoA may be challenging despite the guidance of current diagnostic criteria of the International Classification of Headache Disorders 3 (ICHD-3). In this study, we aimed to disclose the diagnostic gaps in the diagnosis of comorbid MwoA, using a zone concept, in patients with I/GEs with headaches who were diagnosed by an experienced headache expert.MethodsIn this multicenter study including 809 consecutive patients with a diagnosis of I/GE with or without headache, 163 patients who were diagnosed by an experienced headache expert as having a comorbid MwoA were reevaluated. Eligible patients were divided into three subgroups, namely, full diagnosis, zone I, and zone II according to their status of fulfilling the ICHD-3 criteria. A Classification and Regression Tree (CART) analysis was performed to bring out the meaningful predictors when evaluating patients with I/GEs for MwoA comorbidity, using the variables that were significant in the univariate analysis.ResultsLonger headache duration (

Published
2023
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2. The role of vestibular evoked myogenic potential and the video head impulse test in patients with multiple sclerosis without radiologic findings

Author

Reyhan Surmeli, Mehmet Sürmeli, Gözde Günay, Ayşe Destina Yalçın, Ayşe Aslı Şahin Yılmaz, and Fatma Kulalı

Subjects
cervical evoked myogenic potential, dizziness handicap inventory, multiple sclerosis, vestibular system, video head impulse test, Neurology. Diseases of the nervous system, RC346-429
Abstract

Objective: The aim is to evaluate the vestibular system using the video head impulse test (vHIT) and vestibular evoked myogenic potentials (VEMP) in patients with multiple sclerosis (MS) without central vestibular involvement in magnetic resonance imaging (MRI), and to determine whether there was subclinical vestibular system impairment. Materials and Methods: The study comprised 27 patients with MS and 26 healthy participants. The participants had no lesions in the central vestibular system in an MRI taken in the past 3 months. Detailed neuro-otologic and neuro-ophthalmologic examinations were performed on all participants. Then, the Dizziness Handicap Inventory (DHI) was completed for subjective vestibular system evaluation. In addition, vHIT and cervical VEMP (cVEMP) were performed for objective vestibular system evaluation. The results were analyzed statistically. Results: The mean age of the patients in the MS group was 39.3 ± 11.4 years and 42.7 ± 9.7 years in the control group. The median DHI score was 4 (range, 0–8) in the MS group and 2 (range, 0–6) in the control group. There were no statistically significant differences between the DHI score averages of the groups. The mean vestibulo ocular reflex (VOR) gain in vHIT was 0.76 ± 0.21 in the MS group and 0.99 ± 0.13 in the control group. VOR gain was statistically significantly lower in patients with MS. The VOR gain cut-off level was considered as 0.8. Gain level was below the cut-off level in 53.7% of patients with MS. There was no cVEMP response in 31.5% of patients with MS. In addition, patients with MS had prolonged P1 and N1 latencies and decreased P1-N1 peak-to-peak amplitudes. Conclusion: We found subclinical involvement in electrophysiologic tests (vHIT and cVEMP) in patients with MS without MRI lesions and without subjective vestibular system symptoms. We believe that vHIT and cVEMP can be used for subclinical evaluation in patients with MS without central vestibular system involvement in MRI.

Published
2020
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3. Peri-ictal headache: An underestimated prognostic finding associated with idiopathic epilepsies

Author

Esme Ekizoglu, Betül Baykan, Arife Çimen Atalar, Bengi Gül Türk, Duygu Kurt Gök, Pınar Topaloglu, Aynur Özge, Semih Ayta, Füsun Ferda Erdoğan, Seher Naz Yeni, Bahar Taşdelen, Sibel K. Velioğlu, Zuhal Yapıcı, İpek Midi, Serap Saygı, Ulufer Çelebi, Elif Sarıca Darol, Kadriye Ağan, Senem Ayça, Sibel Gazioğlu, Zeynep Vildan Okudan, Nermin Görkem Şirin, Nerses Bebek, Neşe Dericioğlu, İlknur Güçlü Altun, Ayşe Destina Yalçın, Reyhan Sürmeli, Oğuz Osman Erdinç, Abidin Erdal, Demet İlhan Algın, Gülnihal Kutlu, Semai Bek, Yüksel Erdal, Akçay Övünç Özön, Aylin Reyhani, Babürhan Güldiken, Barış Baklan, Bülent Oğuz Genç, Ebru Aykutlu Altındağ, Gökçen Karahan, Güray Koç, Handan Mısırlı, İbrahim Öztura, Kezban Aslan-Kara, Merve Melodi Çakar, Nur Türkmen, Onur Bulut, Ömer Karadaş, Özlem Kesim Şahin, Sevgi Ferik, Mehmet Taylan Peköz, Sibel Üstün Özek, Ülkühan Düzgün, Vildan Yayla, Yasemin Gömceli, and Zeynep Ünlüsoy Acar

Subjects
Behavioral Neuroscience, Neurology, Neurology (clinical)
Abstract

Objective: There are a handful of studies investigating peri-ictal headache (PIH) and its clinical associations in patients with idiopathic/genetic epilepsies (I/GE). This multi-center study aimed to investigate PIH, which is an ignored comorbid condition in patients with I/GE, by headache experts and epileptologists working together. Methods: The data were collected from a cross-sectional large study, using two structured questionnaires for headache and epilepsy features, fulfilled by neurologists. Headaches were classified according to the International Classification of Headache Disorders, third edition, whereas seizure and syndrome types were diagnosed according to International League Against Epilepsy criteria. The patients with a headache starting 24 hours before the onset of the seizure (preictal) or within 3 hours after the seizure (postictal) were defined as patients with PIH. We compared demographic and clinical differences between two groups of patients with and without PIH statistically and used ROC curves to determine a threshold of the total number of seizure triggers associated with the occurrence of PIH. Results: Among 809 (531 females, 65.6%) consecutive patients with I/GE, 105 (13%) patients reported PIH (22 preictal, 82 postictal headaches, and one with both types). Peri-ictal headache was more frequently reported by females and those having a family history of migraine or epilepsy, and it was significantly associated with lower rates of seizure freedom for more than five years, drug resistance, and use of polytherapy, remarkably. Moreover, ROC curves showed that having more than 3 seizure triggers was associated with the presence of PIH. Conclusion: Our findings revealed that PIH may be linked to poor outcomes in I/GEs and seems to be related to a lower ictal threshold precipitated by multiple triggers. Future prospective studies will illuminate the unknown underlying mechanisms and appropriate management strategies for PIH to improve the prognosis.

Published
2023

4. Headache in idiopathic/genetic epilepsy: Cluster analysis in a large cohort

Author

Arife Çimen Atalar, Bengi Gül Türk, Esme Ekizoglu, Duygu Kurt Gök, Betül Baykan, Aynur Özge, Semih Ayta, Füsun Ferda Erdoğan, Seher Naz Yeni, Bahar Taşdelen, Sibel K. Velioglu, Zuhal Yapıcı, İpek Midi, Serap Saygı, Ulufer Çelebi, Elif Sarıca Darol, Kadriye Ağan, Senem Ayça, Sibel Gazioğlu, Zeynep Vildan Okudan, Nermin Görkem Şirin, Nerses Bebek, Neşe Dericioğlu, İlknur Güçlü Altun, Ayşe Destina Yalçın, Reyhan Sürmeli, Oğuz Osman Erdinç, Abidin Erdal, Demet İlhan Algın, Gülnihal Kutlu, Semai Bek, Yüksel Erdal, Akçay Övünç Özön, Aylin Reyhani, Babürhan Güldiken, Barış Baklan, Bülent Oğuz Genç, Ebru Aykutlu Altındağ, Gökçen Karahan, Güray Koç, Handan Mısırlı, İbrahim Öztura, Kezban Aslan‐Kara, Merve Melodi Çakar, Nur Türkmen, Onur Bulut, Ömer Karadaş, Özlem Kesim Şahin, Sevgi Ferik, Mehmet Taylan Peköz, Pınar Topaloğlu, Sibel Üstün Özek, Ülkühan Düzgün, Vildan Yayla, Yasemin Gömceli, Zeynep Ünlüsoy Acar, and Atalar A. C., TÜRK B. G., Ekizoglu E., Gok D. K., BAYKAL B., ÖZGE A., Ayta S., ERDOĞAN F. F., YENİ S. N., Tasdelen B., et al.

Subjects
Adult, Adolescent, CHILDHOOD, UNITED-STATES, CHILDREN, idiopathic epilepsy, CLINICAL NEUROLOGY, Sağlık Bilimleri, Clinical Medicine (MED), CLASSIFICATION, MIGRALEPSY, MECHANISMS, Cohort Studies, Nöroloji, Seizures, Health Sciences, Cluster Analysis, Humans, Klinik Tıp (MED), JUVENILE MYOCLONIC EPILEPSY, Child, KLİNİK NÖROLOJİ, Internal Medicine Sciences, Klinik Tıp, headache phenotypes, Myoclonic Epilepsy, Juvenile, Headache, Life Sciences, Electroencephalography, Dahili Tıp Bilimleri, CLINICAL MEDICINE, Tıp, PREVALENCE, MIGRAINE, Neurology, Medicine, myoclonic seizures, Epilepsy, Generalized, genetic epilepsy, Neurology (clinical), BURDEN
Abstract

© 2022 International League Against Epilepsy.Objective: The link between headache and epilepsy is more prominent in patients with idiopathic/genetic epilepsy (I/GE). We aimed to investigate the prevalence of headache and to cluster patients with regard to their headache and epilepsy features. Methods: Patients aged 6–40 years, with a definite diagnosis of I/GE, were consecutively enrolled. The patients were interviewed using standardized epilepsy and headache questionnaires, and their headache characteristics were investigated by experts in headache. Demographic and clinical variables were analyzed, and patients were clustered according to their epilepsy and headache characteristics using an unsupervised K-means algorithm. Results: Among 809 patients, 508 (62.8%) reported having any type of headache; 87.4% had interictal headache, and 41.2% had migraine. Cluster analysis revealed two distinct groups for both adults and children/adolescents. In adults, subjects having a family history of headache, ≥5 headache attacks, duration of headache ≥ 24 months, headaches lasting ≥1 h, and visual analog scale scores > 5 were grouped in one cluster, and subjects with juvenile myoclonic epilepsy (JME), myoclonic seizures, and generalized tonic–clonic seizures (GTCS) were clustered in this group (Cluster 1). Self-limited epilepsy with centrotemporal spikes and epilepsy with GTCS alone were clustered in Cluster 2 with the opposite characteristics. For children/adolescents, the same features as in adult Cluster 1 were clustered in a separate group, except for the presence of JME syndrome and GTCS alone as a seizure type. Focal seizures were clustered in another group with the opposite characteristics. In the entire group, the model revealed an additional cluster, including patients with the syndrome of GTCS alone (50.51%), with ≥5 attacks, headache lasting >4 h, and throbbing headache; 65.66% of patients had a family history of headache in this third cluster (n = 99). Significance: Patients with I/GE can be clustered into distinct groups according to headache features along with seizures. Our findings may help in management and planning for future studies.

Published
2022

6. Photosensitive Temporal Lobe Epilepsy: A Case Report

Author

Ayşe Destina YALÇIN and Reyhan SÜRMELİ

Subjects
intermittant photic stimulation, photosensitive epilepsy, reflex epilepsy, temporal lobe epilepsy, video eeg, Neurology. Diseases of the nervous system, RC346-429, Medicine
Abstract

Photic-induced seizures are usually generalized or arise from the occipital cortex. In the present study, we reported an unusual case of photosensitive temporal lobe epilepsy in a patient who developed photosensitive occipital lobe epilepsy between the age of 5 and 16 y and thereafter developed typical focal seizures with impaired awareness that occurred spontaneously and were induced by watching television. A typical focal seizure with impaired awareness recorded during a short video-electroencephalography monitoring induced by intermittent photic stimulation arising from the left anterior temporal region helped in confirming a diagnosis of photosensitive temporal lobe epilepsy.

Published
2021
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7. Effects of Antiepileptic Drugs on Bone Density and Metabolism

Author

Zeynep AYDIN ÖZEMİR and Ayşe Destina YALÇIN

Subjects
antiepileptic drugs, calcium metabolism, decrease in bone mineral density, Neurology. Diseases of the nervous system, RC346-429, Medicine
Abstract

Many studies have demonstrated that both classic (e.g., phenobarbital, carbamazepine, valproate) and new antiepileptic drugs (e.g., oxcarbazepine, gabapentin) decrease bone metabolism. Abnormalities in calcium metabolism often occur on inducing the cytochrome P450 enzyme system, thus decreasing vitamin D levels. However, the reason some antiepileptic drugs that suppress (e.g., valproate) or have no effect on this system also affect vitamin D metabolism is not known. This study explored the effect of classic and new antiepileptic drugs on bone health and calcium metabolism.

Published
2017
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