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Dual-task performances may be impaired with the impairment in motor performance and cognitive functions due to aging. The aim of the present cross-sectional study is to investigate the gender differences in dual-task performance. A total of 82 community-dwelling older adults (41 males and 41 females) aged between 65 and 75 years were included. Motor performance was evaluated with the sit-to-stand test, the timed up and go test, 10 m walking test and cognitive functions were evaluated with Montreal Cognitive Assessment Test. Dual-task performances were evaluated as motor-motor and cognitive-motor performance. Mean age was 70.12±3.18 years for females and 69.80±3.21 years for males. Both groups were similar with regard to age, education status, exercise habits, and working status. In dual-task performances, females were found to complete motor-motor tasks in a shorter time as compared to males (p=0.001). Cognitive-motor task performances were found to be better in males (p=0.038). It is considered that gender differences in dual-task performances could be understood better in the light of the results of the present study and treatment may be arranged in accordance with these gender differences.

Objectives: To compare patients with symptomatic nodal hand osteoarthritis (OA) with a control group in respect of inflammation parameters, uric acid, and hematological parameters. Methods: The study included 50 post-menopausal female patients, aged 40-80 years, diagnosed with symptomatic nodal hand OA, and a control group of 50 post-menopausal females in the same age range with no hand OA. Patient data including age, monocyte, neutrophil, lymphocyte, and thrombocyte counts, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, uric acid level, and the Kellgren-Lawrence (KL) score obtained from evaluations of hand radiographs, were recorded retrospectively from the hospital information system. The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and monocyte-lymphocyte ratio (MLR) were calculated. The data were compared between the two groups. Results: The data of 100 females were compared, comprising a patient group of 50 patients with symptomatic nodal OA, and a control group of 50 females. Age, monocyte, neutrophil, lymphocyte, and thrombocyte counts, NLR, PLR, MLR, ESR, CRP, and uric acid level were compared. With the exception of MLR and ESR, no statistically significant difference was determined between the two groups. The MLR was determined to be statistically significantly higher in the control group than in the patient group (p = 0.024). The ESR was determined to be statistically significantly higher in the patient group than in the control group p < 0.001). When patients with a KL score of 2 and 3 were compared, with the exception of age, no other difference was determined. Patients with a KL score of 3 were seen to be significantly older (p = 0.032). Conclusions: ESR was determined to be significantly higher in patients with symptomatic nodal OA. Clarification of the relationship between inflammation, uric acid, and hand OA, which is a heterogeneous disease, will be useful in the follow-up and treatment of patients.

This study aimed to determine the possible relationship between periodontal disease and ankylosing spondylitis (AS) by evaluating clinical periodontal measurements and gingival crevicular fluid (GCF) levels of sclerostin, interleukin-1β (IL-1ß), and matrix metalloproteinase-8 (MMP-8) levels.Twenty-eight patients with AS (AS group) and 28 systemically healthy controls (C group) were enrolled in this study. Full-mouth periodontal measurements: plaque index, bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL) measurements were obtained from all patients. AS-related parameters were included in the data analyses. An enzyme-linked immunosorbent assay determined GCF IL-1β, MMP-8, and sclerostin levels.There were no significant differences in the clinical periodontal measurements between the two groups (p 0.05). Interestingly, patients with AS had significantly lower GCF sclerostin levels than the C group (p 0.05). But there were no statistical differences in the GCF levels of IL-1ß and MMP-8 between the two groups (p 0.05). Serum C-reactive protein (CRP) levels strongly correlated with both BOP (r = 0.497, p 0.05) and PPD (r = 0.570, p 0.05) in the AS group. Bath AS Metrology Index (BASMI) also positively correlated with both BOP (r = 0.530, p 0.05) and CAL (r = 0.568, p 0.05). Similarly, Maastrıcht Ankylosing Spondylitis Enthesis Score (MASES) strongly correlated with both BOP (r = 0.487, p 0.05) and CAL (r = 0.522, p 0.05).These results suggest that the patient's systemic condition may influence local sclerostin levels in GCF, and the strong correlations between periodontal measurements and AS-related parameters may indicate an interrelationship between inflammatory periodontal disease and AS.The present study provides important information concerning the relationship between periodontal disease and ankylosing spondylitis.Thai Clinical Trials.gov (TCTR20200908001) (08. September 2020).

Objectives: In this study, we aimed to evaluate the factors associated with disability and quality of life (QoL) in Turkish patients with systemic sclerosis (SSc). Patients and methods: Between January 2018 and January 2019, a total of 256 SSc patients (20 males, 236 females; mean age: 50.9±12.4 years; range, 19 to 87 years) who were diagnosed with SSc were included in the study. Disability and health-related QoL (HRQoL) were evaluated by the Health Assessment Questionnaire (HAQ), scleroderma HAQ (SHAQ), Duruöz Hand Index (DHI), and Short Form-36 (SF-36). Linear regression analysis methods were used to describe factors associated with disability and QoL of the patients. Results: All disability scores were higher and HRQoL scores were lower in diffuse cutaneous SSc patients compared limited cutaneous SSc, and differentiations were significant (p=0.001 and p=0.007). In multiple regression, pain (VAS) was the strongest predictor for high disability and low QoL scores (p Conclusion: Clinicians should consider the management of the pain and its sources as a key to improve better functional state and quality of daily life in SSc.

This study aimed to determine the relationship between pain intensity and anxiety levels related to surgery in patients scheduled for lumbar surgery due to low back pain. Fifty-seven patients (30 females, 27 males) scheduled for lumbar surgery for various reasons were included in the study. Demographic and clinical information of the patients were recorded. The state of being informed about the surgery and the reasons for anxiety about the surgery were questioned. Pain intensity at rest, in activity, and at night were evaluated using the Visual Analogue Scale and surgery-related anxiety levels with the Spielberg State-Trait Anxiety Inventory preoperatively, postoperatively, and at discharge. Mean age of the patients was 55.00±9.37 years. A statistically significant positive correlation was found between the intensity of rest, activity, night pain, and the anxiety level in the preoperative period (p

Although it is known that physical activity has many effects on health, various factors are effective in providing and maintaining activity. The aim of this study was to determine the exercise beliefs of young adults and to investigate the relationship between exercise beliefs, physical activity levels and motivation to participate in physical activity. A total of 551 volunteer participants between the ages of 18-25 were included in the study. The Exercise Beliefs Questionnaire (EBQ) was used to determine the participants' beliefs about exercise, the Physical Activity Index (PAI) to determine their physical activity levels, and the Motivation to Participate in Physical Activity Scale (MPPAS) to determine exercise motivation. The mean age of the participants was 21.13±1.87 years. It was determined that 220 (39.9%) of the participants had exercise habits and 331 (60.1%) did not have exercise habits. It was observed that those who exercised were more positive about the benefits of exercise, while those who did not exercise had more negative attitudes (p= 0.001). PA levels (p=0.001) and motivation levels (p=0.001) were found to be significantly higher in those who had exercise habits. A positive, moderately strong, statistically significant relationship was found between exercise beliefs-benefits subscale and exercise motivation (r=0.513; p

Background and aim: Students’ awareness of low back pain should be increased in undergraduate education in order to increase their ability to use evidence-based practices while undertaking the treatment of patients with low back pain. This study was conducted to determine the knowledge levels of low back pain and their beliefs and attitudes towards low back pain, and to investigate the relationship between knowledge level and beliefs-attitudes of senior physiotherapy students. Materials and methods: A total of 235 students (153 females, 82 males) from Pamukkale University School of Physical Therapy and Rehabilitation who received training in Neurosurgery and Rehabilitation Clinical Practice were included. The knowledge levels of the students about low back pain were determined by the Low Back Pain Knowledge Questionnaire (LBPKQ). Their orientation in the treatment of low back pain was evaluated with the Physiotherapists' Attitudes and Beliefs Questionnaire about Low Back Pain (PABS-PT-TR). Results: The mean age of the students was 22.78±1.96 years. LBPKQ mean was 19.25±3.05. The mean biomedical orientation sub-dimension of the PABS-PT-TR questionnaire was 32.45±4.83 points, and mean biopsychosocial orientation sub-dimension was 23.14±4.13 points. There was no statistically significant relationship between LBPKQ and PABS-PT-TR sub-dimensions (p>0.05). Conclusion: Attitudes and behaviors of students about low back pain were mostly related to body structure and functions. However, it is important to evaluate and treat the patient not only from a biological point of view but also from a biopsychosocial point of view in order to achieve success in the treatment of low back pain.

Amaç: Bu çalışmada bel ağrılı bireylerde ağrı şiddetini ve özür düzeyini etkileyen faktörlerin araştırılması amaçlandı. Gereç ve Yöntem: Pamukkale Üniversitesi Nöroşirurji Polikliniğine bel ağrısı şikayetiyle başvuran 205 (131 kadın; 74 erkek) hasta çalışmaya dâhil edildi. Hastaların demografik bilgileri kaydedildikten sonra ağrı şiddeti, özür düzeyi, ağrı şiddetini ve özür düzeyini etkileyen faktörler sorgulandı. Ağrı şiddetini belirlemek için Görsel Analog Skalası (GAS) ve özür düzeyi için Oswestry Özür İndeksi (OÖİ) kullanıldı. Bulgular: Katılımcıların ortalama yaşı 47,96 ± 16,41’dir. Ağrı şiddeti ortalamaları 6,18 ± 2,27 cm ve ağrı süreleri 98,72 ± 222,10 hafta olarak bulundu. Özürlülük düzeyi ortalamaları 44,93 ± 18,73 idi. Katılımcıların 125’i (%61) yürümede, 113'ü (%55,1) uzun süre ayakta kalmada ve 106’sı (%51,7) öne eğilme sırasında ağrı şiddetinde artış olduğunu belirtti. Yokuş inmenin, oturmanın, öne eğilmenin ağrıyı en çok arttıran faktörler ve basamak çıkmanın, yokuş çıkmanın, ev iş yapmanın özür düzeyini arttıran faktörler olduğu saptandı. Sonuç: Bel ağrısı olan hastalarda ağrı şiddetini artıran ve özür düzeyini etkileyen faktörlerin belirlemesi, hastaların bu konuda bilinçlendirilmesi ve önleyici tedbirlerin alınması açısından önemlidir

The aim of this study was to determine the perspectives of the students of the physiotherapy and rehabilitation department towards the disabled and their attitudes towards the education of the disabled. Sixty-eight volunteer students (50 females, 18 males) studying at Pamukkale University School of Physical Therapy and Rehabilitation and taking the Psychosocial Rehabilitation course in the Spring Semester of the 2020-2021 Academic Year participated in the study. The Attitude Toward Disabled Persons Scale (ATDPS) was used to evaluate the positive and negative attitudes of the students towards the disabled individuals, and the Attitude Scale for the Training of Individuals with Disabilities (ASTID) was used to determine their views on the education of the disabled individuals. Evaluations were made at the beginning and end of the relevant semester. The mean age of the students was 19.44±1.07 years. In the first evaluation, the mean of ATDPS was 50.75±13.92 and the total score of ASTID was 51.04±18.42 points. At the last evaluation, the ATDPS score increased to 78.36±13.77 and the ASTID total score to 93.13±7.48 (p=0.0001). Providing students with basic information about various disability groups and their rehabilitation will increase the level of awareness towards people with disabilities. It is important to develop positive attitudes towards the disabled throughout society in order for the disabled to feel themselves as a part of social life and to increase their participation in social life. It will contribute to the increase of the social awareness of the organizations to be organized regarding the education of the disabled and disabled people. Organizations to be held regarding disabled people and the education of the disabled will contribute to the increase of social awareness.

Background and aim: Due to the pandemic, all courses and exams in the physiotherapy and rehabilitation department continue through online training. The purpose of this study is to evaluate the online practical courses and exams from the point of view of the students of the physiotherapy and rehabilitation department. Materials and methods: Two hundred volunteers who are 2nd and 3rd year students taking practical vocational courses online at Pamukkale University School of Physical Therapy and Rehabilitation in the fall semester of the 2020-2021 academic year were included in the study. Students who accepted to participate in the study were sent an evaluation form prepared via Google Forms and asked to fill it out online. The level of satisfaction with the online method of teaching applied courses was evaluated using the Satisfaction Scale for E-Course (SSEC) and the online method of conducting the exams using the E-Assessment Attitude Scale (EAAS). Results: A total of 200 students (145 female, 55 male) with a mean age of 21.36±2.70 years were included in the study. 43.5% (n=87) of the students were second-year students and 56.5% (n=113) were third-year students. 79% (n=158) of the students stated that face-to-face education is better than distance education, 17.5% (n=35) stated that distance education is sufficient and 3.5% (n=7) stated that face-to-face education is stated that there was no difference between the mean total score of the second graders on SSEC was 112.80±31.73, and the total score on EAAS was 67.36±13.72. The mean total score of SSEC of the third graders was 100.46±26.76, and the total score of EAAS was 66.60±11.69. While the second-year students' level of satisfaction was higher (p=0.004), their views on exams were similar (p=0.677). A statistically significant positive correlation was found between the students' level of satisfaction with the course and their perspectives on the exams (p=0.001; r=0.369). Conclusion: Although the course materials are rich during distance education in the 3rd grade, where the application-oriented courses are more intense, the level of satisfaction with the courses is lower since the students do not have the opportunity to practice one-on-one. In order to eliminate these deficiencies of the students, concentrated practical trainings can be applied in small groups under pandemic conditions.

In chronic obstructive pulmonary disease(COPD) patients use extensively supplementary respiratory muscles such as trapezium and scalenes muscles in order to facilitate ventilation. These situations cause pain restricting by the upper body mobility and neck movements. This study was conducted to investigate the presence of neck pain in individuals with COPD and to compare it with healthy individuals. The study included sixty-two patients with COPD(COPD group) and sixty-two healthy volunteer subjects(control group). Visual Analog Scale(VAS) to determine pain intensity were used. Severity of neck disability level and the effects of pain on daily life were evaluated by Neck Disability Index and Nordic Musculoskeletal System Questionnaire. Chest mobility was assessed by circumference measurement. VAS of the COPD group was higher than the control group (p

Recent developmental psychology studies conducted within the context of values and children’s value acquisition have shown that even during the early years of middle childhood, children’s value priorities can occur. Parents, who are the primary actors in the socialization process, play an important role in the value development of their children. In this study, the similarities between mother–child dyads in terms of the 10 value types of Schwartz were examined. For this aim, a total of 172 mothers and their children between ages 6–11 years attending 1st, 2nd, 3rd, and 4th grade in primary schools in Ankara were included in this study. The Portrait Value Questionnaire was used to assess mothers’ values, and the Picture-Based Value Survey was used to assess children’s values. The findings showed that mothers gave priority to the values of achievement, security, and self-direction and high-order values of self-enhancement and conservation. In contrast, it was found that children gave priority to the values of tradition, benevolence, and universality and higher order values of self-transcendence and conservation. Furthermore, it was seen that the values of the mother–child dyads had lower similarities, and the order of the priority of the value types differed from each other. In addition, our findings revealed that there were significant relationships among the mother’s education, total monthly income, and mother–child value similarity, which varied according to the age of the child. While the mothers’ education and total monthly income were not associated with the mother–younger child value similarity, these were negatively associated with the mother– older child value similarity. Similarly, it was observed that the relationship among the mothers’ education, total monthly income, and mother–child value similarity also varied according to the gender of the child. While the mothers’ education and total monthly income were not associated with the mother–son value similarity, these were negatively associated with the mother–daughter value similarity. In conclusion, it is thought that these findings can provide information about the intergenerational transfer of values and provide guiding clues for the regulation of curriculum related to value education in schools.

Kent içi seyahatlerde engellilerin birçok problemle karşılaştığı bilinmektedir. Şimdiye kadar yapılmış bilimsel çalışmaların yaya hizmet düzeyi (YHD) tespiti kısmında engelliler için gerekli olan parametreler göz ardı edilmiş, engelli yayaların ihtiyaçları mevcut YHD modellerine yansıtılmamıştır. Bu eksikliği ortadan kaldırmak için YHD belirlenirken engelli kişilerinde ihtiyaçlarının dikkate alınması uygun olacaktır. Çalışmada, mevcut hizmet düzeyi modeline, engelli bireylerin seyahat ihtiyaçları eklenerek tüm yaya yol kullanıcıları için yeni bir YHD belirlenmiştir. Bunun için daha önceki çalışmalarda engelli bireylere yapılan anket sonuçları incelenmiştir. Çalışmanın özgünlüğünü arttıran kısım ise bugüne kadar yapılmış literatürden elde edilen engelli yaya ihtiyaç parametrelerinin ayrı ayrı kullanılarak hizmet düzeyi hesabına eklenmesi olmuştur. GYHD (Genel Yaya Hizmet Düzeyi Modeli), EYHD (Engelli Yaya Hizmet Düzeyi) ve bunların her ikisini de bünyesinde bulunduran yeni bir YHD modeli oluşturulmuştur. Hizmet düzeyi tespiti Süleyman Demirel Üniversitesi Batı Yerleşkesinde uygulanmıştır fakat, modelin parametre sınır değerlerinin literatürdeki uluslararası standartların sonuçlarına dayanması nedeniyle, bulunan modelin evrensel olarak uygulanabilir olduğu söylenebilir., It is well-known that urban travel for people with disabilities is fraught with difficulties. The parameters required for the disabled have been overlooked in the scientific studies so far, and the needs of disabled pedestrians have not been reflected in the existing YHD models. There is a need to consider the needs of people with disabilities when determining YHD in order to eliminate this deficiency. Pedestrians with disabilities were added to the existing service level model in this study to determine a new YHD for all pedestrians. In previous studies, results of questionnaires given to people with disabilities were examined for this purpose. The addition of the disabled pedestrian need parameters obtained from the literature to the service level calculation by using them separately increased the originality of the study. This model, which incorporates both the GYHD (General Pedestrian Service Level Model) and the EYHD (Disabled Pedestal Service Level), was developed. It was found that the model developed by Süleyman Demirel University West Campus was universally applicable due to the model's parameter limit values being based on results from international standards.

In Zeiten groser internationaler Krisen und damit verbundener Fluchtlingsbewegungen ist festzustellen, dass es in der ambulanten diabetologischen Praxis bei der Anamnese und Therapie von Patienten mit Migrationshintergrund haufig nicht nur durch eine hohe Sprachbarriere und strukturelle Unwissenheit zu Schwierigkeiten kommen kann. Haufig liegen die Schwierigkeiten auch darin begrundet, dass das aufnehmende Gesundheitssystem in seinen Strukturen nur wenig kultursensibel erscheint und haufig seitens sowohl des Personals als auch der Therapiemasnahmen nicht ausreichend auf die „neue Patientenschaft“ vorbereitet ist. Eine Folge hieraus sind schlecht eingestellte Patienten, die aufgrund langanhaltender uberhohter Werte eine Vielzahl an Begleit- und Folgeerkrankungen entwickeln und tendenziell deutlich fruher als die vergleichbare ortliche Bevolkerung eine Multimorbiditat entwickeln. Dem liese sich durch entsprechende Anpassung der Aus‑, Fort- und Weiterbildung von Arzten und medizinischem Personal leicht vorbeugen, und die langfristigen Folgen fur das Gesundheitssystem und die Patienten wurden minimiert werden.

Objectives: This study aims to evaluate the relationship between C-reactive protein (CRP)/albumin ratio (CAR) and other hematological parameters in Behçet's disease (BD). Methods: A total of 200 participants (100 BD patients and 100 healthy control) were recruited from the rheumatology outpatient clinic in this cross-sectional study. Laboratory tests were conducted to measure complete blood count, erythrocyte sedimentation rate (ESR), CRP, albumin, CAR, neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR). Laboratory findings of BD patients and healthy controls were compared and evaluated. BD Activity scores (Behçet's Disease Current Activity Form [BDCAF]) were calculated. Results: In the BD group, there were 42 male and 58 female participants with a mean age of 42.49 ± 13.15 years and in the healthy control group, 44 male and 56 female participants with a mean age of 44.90 ± 10.98 years. NLR, CRP, ESR and CAR values were significantly higher in patient group than in the healthy controls (p < 0.05). BDCAF score varied between 0 and 4 with a mean of 1.55 ± 0.64. A statistically significant correlation was observed between BDCAF and CRP, ESR and CAR (p < 0.0001). Conclusions: In this study, a significant correlation was found between CAR and BDCAF, NLR, CRP, albumin and ESR. CAR can be useful in the diagnosis and following of BD patients.

The present study examined pedestrian movements in five pedestrian crossings in Adana, Mersin, and Isparta provinces in the Mediterranean Region of Turkey. The effects of factors that contribute significantly to pedestrian crossing time were considered. Linear (multiple linear regression [MLR]), nonlinear (artificial neural network [ANN], adaptive neuro-fuzzy inference system [ANFIS]), particle swarm optimization (PSO), and crossing time models reported in the literature were used to estimate crossing times and compare the estimations to the collected data. The nonlinear ANN and ANFIS models achieved better predictions than the linear MLR. The models from the literature achieved worse results compared to the other models due to the limited number of included parameters, The model coefficients were calibrated with PSO to improve regional specificity and the accuracy of the predictions improved. Calibrating the models according to the characteristics of the study region improves the accuracy of the findings.

“Torsades de pointes”, a life-threatening rhythm disorder, is a polymorphic ventricular tachycardia that usually develops in association with a prolonged QT interval. Fluconazole, an anti-fungal drug, may also induce QT prolongation, in some cases subsequent torsades de pointes. Herein, we report a 16-year-old female presenting “torsades de pointes” after administration of fluconazole and rapidly improved upon cessation of the drug.

Amac: Gastrektomi halen mide kanseri tedavisinde en onemli yere sahip iken son yillarda laparoskopik cerrahilerin avantajlarinin gastrik kanser cerrahisinde de oldugunu gosteren yayinlarin cikmasi ile daha populer hale gelmistir. Midenin komsu organ ve damarlar ile yakin iliskisi ve farkli lenfatik yollarin olmasi laparoskopik gastrik kanser tedavisini zorlu kilmaktadir. Tumor histolojisi, cerrahi sinir pozitifligi, batin yikama sitolojisindeki (+) ve yetersiz lenfatik disseksiyon lokal ve sistemik metastazlarin olusmasindaki en onemli faktorlerdendir. Bu calismada Cukurova universitesi genel cerrahi kliniginde gerceklestirilen laparoskopik gastrektomilerin erken donem sonuclarinin paylasilmasi amaclanmistir. Gerec ve Yontem: Eylul 2015 - Eylul 2018 tarihleri arasinda yapilan laparoskopik gastrektomiler total ve distal olmak uzere iki gruba ayrilmis teknik, patolojik sonuc ve erken postoperatif komplikasyonlar acisindan incelenmistir. Bulgular: Calismaya 11’i erkek, 7’si kadin olmak uzere 18 hasta dahil edilmistir. Yas ortalamasi 57,4 olup, ortalama BMI 26,3 idi. 13 hastada cerrahi ilk planda tutulmus sadece bes hastaya neoadjuvan tedavi protokolu uygulanmistir. Total gastrektomi 14 hastada , distal gastrektomi 4 hastada tercih edilen ameliyat yontemidir. Tum hastalara tumor yerlesimine gore standart D2 lenf disseksiyonu uygulandi ve Total gastrektomi grubunda Ortalama 33,2 distal gastrektomi grubunda 32 lenf nodu disseke edildi. Ortalama oral baslama suresi ve Total gastrektomi grubunda 6,4 gun distal gastrektomi grubunda 2,5 gun idi. Duodenal guduk kacagi 4 hastada, ozefagojejunostomi kacagi 2 hastada tespit edilirken 1 hastada da dren yerinde kanama goruldu. Sonuc: Laparoskopik gastrektomi ve lenfatik disseksiyonun yeterliligini gosteren bir cok calisma bulunmaktadir. Ancak ogrenim sureci uzun, teknik zorluklari fazla olan bu ameliyatlarda deneyim ve tecrube arttikca ameliyat surenin kisalacagini ve komplikasyon oraninin azalacagini dusunmekteyiz.

Non–small cell lung cancer (NSCLC) constitutes more than 85% of lung cancer case. Pemetrexed is used to treat types of NSCLC, and pazopanib is used for some types of soft tissue sarcoma. The aim of the study was development of pemetrexed and pazopanib carrying nanobubble system with magnetic responsiveness and ultrasound sensitivity properties for targeted NSCLC therapy. Drugs were linked to newly designed peptide, and peptide drug conjugates were attached to amine-modified magnetite. Resulting nanoparticles were encapsulated into liposomes, and liposomes were extruded, then nanobubble system was prepared. Moreover, nanobubble biodistribution was monitored by in vivo imaging system. As a result, based on high-performance liquid chromatography data, magnetite and peptide-pemetrexed were conjugated with 54.02% yield, and magnetite and peptide-pazopanib were bound with 63.53% yield. Hydrodynamic size of nanobubbles, prepared from liposomes filtered through 800 nm and 400 nm, was determined as 491.1 ± 130.2 and 275.8 ± 117.8 nm, respectively. Carrier system was accumulated into tumor area with 80.22% yield of the injected carrier system. It was found that nanobubbles were magnetic responsive for accumulation via magnetic field and could be disrupted by ultrasound via focused acoustic pressure, which lead to targeted drug delivery. These nanobubble systems could be investigated for intravenous and inhaler administration in further studies.

Dil kültür ilişkisi dilin ortaya çıktığı ilk andan yaşadığı son ana kadar devam eden bir olgu ve durumdur. Dil, ürettiği her yeni kavramı kültürün içerisine bırakır. Bu ürünler yıllar içinde damıtılır ve dilin en veciz ifadeleri olan atasözleri ve deyimler içerisinde yaşamını sürdürür. Bu çalışmada, Ömer Asım Aksoy tarafından hazırlanmış olan “Atasözleri ve Deyimler Sözlüğü I-II” ile Türk Dil Kurumu tarafından yayımlanmış olan “Bölge Ağızlarında Atasözleri ve deyimler I-II” adlı eserlerde geçen baht ve baht ile ilgili kelimeler atasözlerimizde ve deyimlerimizde tespit edilmeye çalışılmıştır.Bu eserler, dilimizde kullanılan atasözleri ve deyimlerin derlenerek bir arada sunulduğu önemli kaynaklardır. Bu kıymetli eserler, sadece kaynak olarak yararlanılan eserler değil; milletimizin ulusal varlıklarını merak edenler için içerisinde bulunan arkaik kelimelerle birlikte değerli birer tarihi vesikalardır. Çalışmada dil-kültür ilişkisi içerisinde derin anlamları olan ve dili kullanan insanların umutlarını, mutluluklarını ve bunun gibi duygu ve durumları karşılamak için kullandıkları baht, talih, kut, devlet, kısmet, uğur gibi kelimelerin atasözleri ve deyimlerimiz içerisindeki kullanımları tespit edilerek halk irfanındaki yerleri belirlenmeye çalışıldı., Language is the phenomenon and condition that continues until the last moment when language-related language has emerged. Every new concept of language production is left in the culture. These products are distilled over the years and the language continues its life in proverbs and idioms which are the most vehement expressions. In this work, the words "Proverbs and Idioms Dictionary I-II" prepared by Ömer Asım Aksoy and other words about luck and related to luck in "Proverbs and Expressions I-II in the Dialects of the Region" issued by the Turkish Language Institute are not to be found in our proverbs and idioms that studied.These works are the best-collected examples of the proverbs and idioms used in our language in general terms. These precious works are not only books that are used as source books; It is a valuable historical vocation along with the archaic words that are in place for those who are interested in national wealth. In the study, it was tried to determine the places of public awareness by determining the proverbs and utterances of words such as baht, luck, kut, devlet, fortune, luck etc. used by people who have profound meanings in language and culture and who use language to meet their hopes, happiness and emotions and situations like this.

BACKGROUND: Regular exercise habits provide social and psychological benefit as well as improving and ameliorating the physical health of individuals. This study was conducted to examine the effect of regularly exercising on self-efficacy, self-esteem and body awareness on healthy adults. METHODS: Three hundred and fifty two participants (141 females, 211 males) aged 20 to 40, who do regularly exercise at least two days a week for last 6 months (REG), and 350 sedentary individuals (212 females, 138 males; SG). Demographics of participants and the type, duration, and frequency of the exercise were recorded. Self-efficacy (General Self-Efficacy Scale), self-esteem (Rosenberg Self-Esteem Scale) and body awareness (Body Awareness Questionnaire) levels of the participants were assessed. RESULTS: The mean age of REG was 23.34 +/- 3.67 years and SG was 22.66 +/- 2.67 years. It was found statistically significant differences in terms of self-efficacy, self-esteem and body awareness between groups and the results of participants who were doing exercise regularly were much better than sedentary ones (P

The aim of this study was the preparation of solid lipid nanoparticles (SLN) formed from cetyl palmitate with having targeting molecules for monocarboxylate transporter-1 (MCT-1): p-hydroxybutyric acid and anticancer agents: carmustine (BCNU) and temozolomide (TMZ) for enhanced anti-proliferation against glioblastoma multiforme (GBM). Properties including size, morphology, chemical structure, zeta potential, drug encapsulation efficacy, drug release, biocompatibility, stability were determined, and in vitro studies were done. BCNU and TMZ loaded SLNs had a hydrodynamic size of 227 nm +/- 46 a zeta potential of -25 mV +/- 4 with biocompatible features. The data showed rapid drug release at first and then continuous release. Nanoparticles could be stored for nine months. BCNU and TMZ loaded SLNs exhibited a remarkable increment in the antitumor activity compared to the free-drugs and induced apoptosis on U87MG cells. In addition, targeted nanoparticles were more uptaken by MCT-1 expressing brain cells. This study indicated that BCNU and TMZ loaded SLNs could act as a useful anticancer system for targeted GBM therapy., Scientific and Technological Research Council of Turkey, TUBITAK [117S241]; Ege University [2019/17444], This work was supported by the Scientific and Technological Research Council of Turkey, TUBITAK (grant number: 117S241). The authors would like to acknowledge to Ege University Center for Drug Research, Development, and Pharmacokinetic Applications (ARGEFAR) for laboratory support and Dursun Demiroz for his illustration and help. We are grateful to Ege University Planning and Monitoring Coordination of Organizational Development and Directorate of Library and Documentation for their support in editing and proofreading service of this study. Patent applications in the national and international areas have been filed for this invention, which have been supported by Ege University (application number 2019/17444).

Andersen-Tawil syndrome is a rare autosomal dominant genetic or sporadic disorder characterized by periodic paralysis, ventricular arrhythmias and dysmorphic features. Ventricular arrhythmias can include frequent premature ventricular complex, polymorphic ventricular tachycardia, and less frequently bidirectional ventricular tachycardia. Left ventricle function has been reported in only a few individual cases of Andersen-Tawil syndrome. A 14-year-old female patient was referred to our clinic from another center with documented arrhythmia and left ventricular systolic dysfunction. Andersen-Tawil syndrome was suspected and the diagnosis was confirmed after detection of a previously unreported mutation in children. We report the successful use of flecainide in bidirectional ventricular tachycardia and tachycardia-induced cardiomyopathy in a case of Andersen-Tawil syndrome associated with a novel mutation.

This study was conducted to investigate the effectiveness of Matrix rhythm therapy (MRT) on muscle tone, balance and gait parameters in stroke survivors. Thirty stroke individuals randomly assigned to study and control group received combining BT&MRT, and BT, respectively. This study was a single-blinded (assessor-blind), randomized controlled trial. A total of 30 stroke individuals with spastic hemiparesis (n = 30) aged between 20–65 years were included. The study group received combining BT and MRT on trunk and the affected lower limb. The control group received only BT. Participants in both groups were received therapy for 4 weeks, 3 days/week. The outcome measures were Modified Ashworth Scale (MAS), goniometric measurements (ROM), Single Leg Stance Test of the BESTest Balance Evaluation System, Timed “Get Up & Go” Test of the BESTest and BTS G-Walk Gait-Analysis System. Spasticity intensity, ROM, static/dynamic balance tests’ scores, gait velocity, cadence, and pelvic movement symmetries improved in study group (p < 0.05).In the control group, only dynamic balance improved after the treatment program(p < 0.05). Significant improvements were found in terms of spasticity intensity, ROM of knee and ankle joints, static/dynamic balance, gait velocity and cadence in favor of the study group (p < 0.05). This study gives preliminary evidence that adding MRT to BT may be beneficial in improving balance and gait by regulating muscle tone in the affected lower limb of stroke patients with spastic hemiparesis. The study was retrospectively registered at Clinical Trials.gov (ID: NCT04213417; URL: www.clinicaltrials.gov). © 2020, Belgian Neurological Society.

Amaç: Serebral palsili çocuklarda en sık karşılaşılan sorunlardan biri, denge kontrolündeki zayıflıktır. Bu çalışmada, diparetik veya hemiparetik serebral palsili çocuklarda 8 haftalık Bobath terapisinin denge üzerine etkisini araştırmayı amaçladık.Gereç ve Yöntem: Çalışmaya 5-14 yaşlarında toplam 15 serebral palsi tanılı (8 diparezi, 7 hemiparezi) çocuk dahil edildi. Çocuklar bağımsız olarak veya yürüme yardımcısıyla yürümektedir. Demografik veriler kaydedildi. Motor fonksiyon seviyesini belirlemek için Kaba Motor Fonksiyon Sınıflandırma Sistemi ve Kaba Motor Fonksiyon Ölçümü kullanıldı. Denge yeteneği için 1 Dakika Yürüme Testi, 10 metre yürüme testi ve Pediatrik Denge Ölçeği ve günlük yaşam aktitivitelerindeki bağımsızlığı değerlendirmek için Çocuklar için Fonksiyonel Bağımsızlık Ölçeği (WeeFIM) kullanıldı. Bobath therapisi toplam 8 hafta boyunca, haftada 2 gün ve bir seansı 60 dakika olacak şekilde uygulandı. Tüm değerlendirmeler tedavi öncesi ve tedaviden sonra yapıldı.Bulgular: 8 haftalık Bobath terapisinden sonra, motor fonksiyonlarda, fonksiyonel bağımsızlık düzeyi ve denge skorlarında istatistiksel olarak anlamlı iyileşmeler olduğu gösterildi.Sonuç: Serebral palsili çocuklarda Bobath terapisi fonksiyonel motor yeteneği, günlük yaşam aktivitelerinde bağımsızlık düzeyi ve denge yeteneğini geliştirir., Purpose: Weakness on balance control is one of the most common problems for children with cerebral palsy. Present study aimed to investigate the effectiveness of 8 week-Bobath therapy on balance in children with diparetic or hemiparetic cerebral palsy.Materials and Methods: A total of 15 cerebral palsy diagnosed children (8 diparesis, 7 hemiparesis) aged 5-14 years, were included in this study. Children could walk independently or by using a walking aid. The demographic data were saved for each case. Gross Motor Function Classification System and Gross Motor Function Measure were used to determine level of motor function. 1 Minute Walking Test, 10-meter Walking Test, Pediatric Balance Scale for balance ability and Functional Independence Measure for children (WeeFIM) for assessing of independence in activities of daily living were used. Bobath therapy were applied to children one 60-minute session, 2 days a week and 8 weeks in total. All evaluations were performed before treatment and repeated after treatment program.Results: After 8-week Bobath therapy, the results showed that improvement in motor function, level of functional independence and balance scores were statistically significant. Conclusion: Bobath therapy improves functional motor ability, independence level on daily living activities, and also balance ability in children with cerebral palsy.

Pachydermodactyly (PDD) is a benign, acquired digital fibromatosis characterized by asymptomatic and progressive swelling of periarticular soft tissue, and is usually seen in young men. The etiology of PDD is not fully understood, but is thought to be due to the result of recurrent mechanical stimulation. PDD is usually diagnosed by clinical evaluation. There are thick collagen bundles and collection of dermal mucin in the histopathology. Treatment is not indicated due to benign prognosis. Rheumatologic diseases, particularly rheumatoid arthritis, affecting the joints of the hands should be considered in the differential diagnosis due to the similarity of the joint involvement.

Dystonia is defined as a movement disorder characterized by involuntary muscular contractions that generate twisting and repetitive movements and/or abnormal postures [1].

Amaç: Bu çalışmada, 9 yıl içerisinde adrenal kitle nedeni ile ameliyat edilen olgularda konvansiyonel ve laparoskopik adrenalektominin sonuçlarının karşılaştırılması amaçlanmıştır.Gereç ve Yöntem: Adrenalektomi uygulanan 81 hasta çalışmaya dahil edildi. Grup 1 konvansiyonel, Grup 2 Laparaskopik cerrahi olarak hastalar iki grupa ayrıldı. İki grup, yaş, cinsiyet, vücut kitle indeksi (VKİ), Amerikan anestezistler derneği skoru (ASA), kitle lokalizasyonu, kitle büyüklüğü ve kitlenin hormonal aktivitesi, operasyon süresi, operasyonda kanama miktarı, yatış süresi, gıdaya başlama süresi, perioperatif mortalite, erken dönem komplikasyonlar ve 90 gün içinde hastaneye tekrar başvuru gibi özellikleri esas alınarak retrospektif olarak karşılaştırıldı. Bulgular: Grup 1’de 22, Grup 2’de 59 hasta mevcut idi. Gruplar arasında yaş, cinsiyet, VKİ, ASA skoru, tümör lokalizasyonu, operasyon endikasyonları, postoperatif komplikasyon, perioperatif mortalite ve 90 gün içinde tekrar başvuru açısından istatistiksel olarak anlamlı fark saptanmadı. Kitlenin hormonal aktivitesi Grup 2’de daha yüksek, boyutu ise daha küçük saptandı. Operasyon süresi (dak), ameliyatta kanama miktarı (ml), oral alım süresi (gün) ve hastanede yatış süresi (gün) Grup 1’de daha fazla ve istatiksel olarak anlamlı bulundu. Sonuç: Laparoskopik adrenalektomi uygun hastalarda, kısa operasyon süresi, az kan kaybı, oral gıdaya erken başlama süresi ve daha kısa hastanede kalış süresi gibi avantajları, ayrıca güvenli olması nedeni ile tercih edilmesi gereken cerrahi yöntem olmalıdır., Purpose: The aim of this study was to compare the results of conventional and laparoscopic adrenalectomy in adrenal mass cases operated on during a 9-year period.Materials and Methods: A total of 81 patients who underwent adrenalectomy were included in the study. Patients were divided into two groups as; Group 1 - conventional surgery and Group 2 - laparoscopic surgery. Two groups were compared retrospectively on characteristics such as; age, sex, body mass index (BMI), American Society of Anesthesiologists' score (ASA), mass localization, mass size and hormonal activity of the mass, duration of operation, amount of bleeding in operation, duration of hospitalization, duration until food intake, perioperative mortality, early complications and readmission to hospital within 90 days. Results: There were 22 patients in Group 1 and 59 patients in Group 2. No statistically significant difference was found between the groups in terms of age, sex, BMI, ASA score, tumor localization, indications for operation, postoperative complication, perioperative mortality and re-admittance within 90 days. The hormonal activity of the mass was higher and the mass was smaller in size in Group 2. The duration of operation (min), the amount of bleeding in the operation (ml), the duration until oral intake (days) and the length of hospital stay (days) were found to be statistically significantly higher in Group 1.Conclusion: Laparoscopic adrenalectomy should be the preferred surgical method because of its short duration of operation, low blood loss, early onset of oral food intake and shorter hospital stay, as well as its safety.