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Experimental data indicate that betatrophin plays a significant role in the regulation of lipid metabolism and glucose homeostasis. In recent years, considerable attention has focused on the relationship between betatrophin and diabetes mellitus in humans. This case-control study included 45 women diagnosed with gestational diabetes mellitus (GDM) and 45 pregnant healthy controls. The groups were matched for maternal and gestational age and body mass index. Serum betatrophin levels were significantly higher in women with GDM (median = 635.8 ng/L; range: 290–1841.6 ng/L) compared to control subjects (median = 320.1 ng/L; range: 94.6–936.8 ng/L;p = 0.001). No significant correlations were observed between serum betatrophin levels and clinical or biochemical parameters in the control group. However, in the GDM group, serum betatrophin levels were positively correlated with weight gain during pregnancy (r = 0.304,p = 0.042), systolic blood pressure (r = 0.394,p = 0.007), fasting insulin level (r = 0.348,p = 0.019), and homeostatic model assessment insulin resistance (HOMA-IR;r = 0.311,p = 0.038). Multivariate stepwise linear regression analysis revealed that fasting insulin levels (β = 0.342,p = 0.022) and HOMA-IR (β = 0.312,p = 0.037) were independently associated with serum betatrophin levels. 实验数据表明，促胰岛生成素在脂质的代谢及糖类的稳态的调节方面起很重要的作用。近年来大量的注意力集中在促胰岛生成素和人类糖尿病的关系上。本病例对照研究包括45例诊断为妊娠期糖尿病的孕妇，以45例健康的孕妇作为对照组。以孕妇、胎龄、体重指数作为匹配项目。妊娠期糖尿病组(中位数=635.8ng/L；范围: 290–1841.6 ng/L)的血清促胰岛生成素水平显著高于对照组(中位数=320.1 ng/L；范围: 94.6–936.8 ng/L; p=0.001)。对照组的血清促胰岛生成素水平和临床、生物化学参数并没有发现有明显相关性。然而，妊娠期糖尿病组血清促胰岛生成素水平和妊娠期间体重增长(r=0.304, p=0.042)、收缩压(r=0.394, p=0.007)、空腹血糖(r=0.348, p=0.019)、与胰岛素抵抗相关的稳态模型(HOMA-IR;r=0.311, p=0.038)均有明显相关性。多元线性回归分析显示空腹血糖(β=0.342, p=0.022)及HOMA-IR (β =0.312, p=0.037)均与血清促胰岛生成素水平有独立相关性。 [ABSTRACT FROM AUTHOR]

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Objectives: To investigate maternal serum ghrelin levels in pregnancies complicated by preeclampsia and to explore the relationship between ghrelin level and disease severity., Materials and Methods: This case-control study included 40 healthy pregnant women, 42 women with mild preeclampsia, and 40 women with severe preeclampsia. The groups were matched in terms of maternal and gestational age and body mass index. Serum ghrelin levels were measured via enzyme immunoassay., Results: Serum ghrelin levels were significantly higher in women with mild and severe preeclampsia than in healthy controls (p < 0.001). Although serum ghrelin levels were somewhat higher in the severe compared to the mild preeclampsia group, the difference was not statistically significant (p > 0.05). In the control group, no significant correlation was observed between ghrelin level and any other parameter, but in the preeclampsia group, serum ghrelin levels were negatively correlated with uterine artery Doppler index values and both systolic and diastolic blood pressure (all p-values < 0.05). Multivariate stepwise linear regression analysis revealed that systolic blood pressure (β = 0.493, p = 0.023) was independently associated with serum ghrelin level., Conclusion: Elevated blood ghrelin levels were correlated with disease severity in pregnancies complicated by preeclampsia.