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This paper presents the structural behavior of precast concrete sandwich panels (PCSPs) containing recycled tyre crumb rubber core under uni‐axial compression and compared with that containing commonly used expanded polystyrene (EPS) foam. A total of six panels were cast and tested. Two for each category of precast concrete panels that is, solid concrete panel, crumb rubber sandwich panel and foam sandwich panel. Results showed that the ultimate axial load of crumb rubber sandwich panel was found to be 91% of solid concrete panel and also exhibited higher structural response in comparison to foam sandwich panel. It was observed that all panels failed in a similar manner by crushing of concrete at ultimate load. Moreover, a finite element model was developed in ABAQUS using in‐built model of concrete plasticity damage to simulate the ultimate axial capacity of recycled tyre crumb rubber concrete sandwich panel and its failure in uniaxial compression. Analysis showed that the finite element modeling slightly overestimated the experimental results. Furthermore, the experimental test results showed that the recycled tyre crumb rubber can be utilized as an alternate core material in PCSPs without substantially compromising the ultimate strength or any change in structural response. [ABSTRACT FROM AUTHOR]