18 results on '"Awa M. Coll-Seck"'
Search Results
2. After COVID-19, a future for the worlds children?
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Kumanan Rasanathan, Yusra Ribhi Shawar, Sarah L Dalglish, Aku Kwamie, Adesola O. Olumide, Mariam Claeson, Peter D. Sly, Mark Tomlinson, Helen Clark, John Borrazzo, Awa M. Coll-Seck, Rajani Ved, Jennifer Harris Requejo, Anshu Banerjee, Jesca Nsungwa-Sabiiti, Papaarangi Reid, Lu Gram, Stefan Peterson, Nigel Rollins, Dina Balabanova, Qingyue Meng, Angela Gichaga, Harshpal Singh Sachdev, David Osrin, Sarah Rohde, Timothy Powell-Jackson, Shanthi Ameratunga, Raúl Mercer, Rana Saleh, Anthony Costello, David B Hipgrave, Jonathon L Simon, Imran Rasul, Tanya Doherty, Sunita Narain, Asha George, Jeremy Shiffman, Zulfiqar A Bhutta, Karin Stenberg, Fadi El-Jardali, and Magali Romedenne
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Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Pneumonia, Viral ,MEDLINE ,Child Welfare ,Global Health ,Betacoronavirus ,Pandemic ,medicine ,Humans ,Child ,Pandemics ,biology ,Viral Epidemiology ,SARS-CoV-2 ,Child Health ,COVID-19 ,General Medicine ,medicine.disease ,biology.organism_classification ,Virology ,Pneumonia ,Psychology ,Coronavirus Infections ,Forecasting - Published
- 2020
- Full Text
- View/download PDF
3. Accelerate progress—sexual and reproductive health and rights for all: report of the Guttmacher– Lancet Commission
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Gamal I. Serour, Cynthia Summers, Susheela Singh, Zeba A. Sathar, Ann E. Biddlecom, Lale Say, Awa M. Coll-Seck, Alex Ezeh, Marleen Temmerman, Robert W. Blum, Anand Grover, Gary Barker, Karin Stenberg, Alaka Malwade Basu, Lori S. Ashford, Anna Popinchalk, Monica Roa, Ann M Starrs, Jane T. Bertrand, and Laura Laski
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Male ,medicine.medical_specialty ,Consensus ,International Cooperation ,Sexual and reproductive health and rights ,MEDLINE ,Commission ,Global Health ,Health Services Accessibility ,03 medical and health sciences ,0302 clinical medicine ,Political science ,Pelvic inflammatory disease ,Reproductive rights ,Global health ,medicine ,Humans ,030212 general & internal medicine ,Reproductive health ,030219 obstetrics & reproductive medicine ,Reproductive Rights ,business.industry ,Health Status Disparities ,General Medicine ,Reproductive Health ,Family medicine ,Domestic violence ,Female ,Sexual Health ,business - Published
- 2018
4. The path to longer and healthier lives for all Africans by 2030: the Lancet Commission on the future of health in sub-Saharan Africa
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Bright Simons, Peter Piot, Edmond S. W. Ng, Irene Akua Agyepong, Agnes Binagwaho, Felix Masiye, Bongani M. Mayosi, Tumani Corrah, Adrian Gheorghe, Maureen O'Leary, Joanne McManus, Nduku Kilonzo, Souleymane Mboup, Helena Legido-Quigley, Nicholas J Kassebaum, Sheila Tlou, Awa M. Coll-Seck, Jean-Jacques Muyembe, Myriam Sidibe, Alex Ezeh, Abebaw Fekadu, Muhammad Pate, Nelson K. Sewankambo, Jamie Enoch, and Peter Lamptey
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Conservation of Natural Resources ,Economic growth ,medicine.medical_specialty ,Biomedical Research ,Double burden ,Health Personnel ,030231 tropical medicine ,Population ,Population health ,Health Services Accessibility ,03 medical and health sciences ,0302 clinical medicine ,Inventions ,11. Sustainability ,Healthcare Financing ,Humans ,Medicine ,Health Workforce ,030212 general & internal medicine ,10. No inequality ,education ,Africa South of the Sahara ,education.field_of_study ,business.industry ,Public health ,1. No poverty ,General Medicine ,Mental health ,Health indicator ,Organizational Innovation ,3. Good health ,Leadership ,Life expectancy ,Public Health ,Rural area ,business ,Delivery of Health Care - Abstract
Sub-Saharan Africa’s health challenges are numerous and wide-ranging. Most sub-Saharan African countries face a double burden of traditional, persisting health challenges, such as infectious diseases, malnutrition, and child and maternal mortality, and emerging challenges from an increasing prevalence of chronic conditions, mental health disorders, injuries, and health problems related to climate change and environmental degradation. Although there has been real progress on many health indicators, life expectancy and most population health indicators remain behind most low-income and middle-income countries in other parts of the world. Our Commission was prompted by sub-Saharan Africa’s potential to improve health on its own terms, and largely with its own resources. The spirit of this Commission is one of evidence-based optimism, with caution. We recognise that major health inequities exist and that health outcomes are worst in fragile countries, rural areas, urban slums, and conflict zones, and among the poor, disabled, and marginalised. Moreover, sub- Saharan Africa is facing the challenges and opportunities of the largest cohort of young people in history, with the youth population aged under 25 years predicted to almost double from 230 million to 450 million by 2050. The future of health in Africa is bright, but only if no one is left behind.
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- 2017
5. A future for the world's children? A WHO-UNICEF-Lancet Commission
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Karin Stenberg, Angela Gichaga, Harshpal Singh Sachdev, Mariam Claeson, Kumanan Rasanathan, David Osrin, Qingyue Meng, Asha George, Peter D. Sly, Jennifer Harris Requejo, Aku Kwamie, Zulfiqar A Bhutta, Sarah L Dalglish, John Borrazzo, Anthony Costello, Jonathon L Simon, Imran Rasul, Stefan Peterson, Awa M. Coll-Seck, Dina Balabanova, Lu Gram, Mark Tomlinson, Papaarangi Reid, Raúl Mercer, Yusra Ribhi Shawar, David B Hipgrave, Tanya Doherty, Magali Romedenne, Sarah Rohde, Fadi El-Jardali, Nigel Rollins, Maharaj K. Bhan, Rana Saleh, Helen Clark, Jesca Nsungwa-Sabiiti, Jeremy Shiffman, Sunita Narain, Rajani Ved, Anshu Banerjee, Timothy Powell-Jackson, Adesola O. Olumide, and Shanthi Ameratunga
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Economic growth ,United Nations ,media_common.quotation_subject ,Child Health Services ,Child Welfare ,Commission ,030204 cardiovascular system & hematology ,Global Health ,World Health Organization ,03 medical and health sciences ,0302 clinical medicine ,Child Development ,Political science ,Global health ,Humans ,030212 general & internal medicine ,Child ,Environmental degradation ,media_common ,Sustainable development ,Government ,Human rights ,Child Health ,General Medicine ,Sustainable Development ,Child development ,Sustainability - Abstract
Executive summaryDespite dramatic improvements in survival, nutrition, and education over recent decades, today’s children face an uncertain future. Climate change, ecological degradation, migrating populations, conflict, pervasive inequalities, and predatory commercial practices threaten the health and future of children in every country. In 2015, the world’s countries agreed on the Sustainable Development Goals (SDGs), yet nearly 5 years later, few countries have recorded much progress towards achieving them. This Commission presents the case for placing children, aged 0–18 years, at the centre of the SDGs: at the heart of the concept of sustainability and our shared human endeavour. Governments must harness coalitions across sectors to overcome ecological and commercial pressures to ensure children receive their rights and entitlements now and a liveable planet in the years to come.
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- 2019
6. Framing an agenda for children thriving in the SDG era: a WHO-UNICEF-Lancet Commission on Child Health and Wellbeing
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Helen Clark, Stefan Peterson, Rajiv Bahl, Anthony Costello, Tamara Lucas, and Awa M. Coll-Seck
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United Nations ,Child Health ,General Medicine ,Commission ,030204 cardiovascular system & hematology ,Public administration ,Sustainable Development ,Global Health ,World Health Organization ,Child health ,03 medical and health sciences ,0302 clinical medicine ,Framing (social sciences) ,Child Development ,Political science ,Child, Preschool ,Thriving ,Child Mortality ,Humans ,030212 general & internal medicine ,Child - Abstract
Framing an agenda for children thriving in the SDG era : a WHO-UNICEF-Lancet Commission on Child Health and Wellbeing.
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- 2018
7. The Lancet Commission on pollution and health
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Kirk R. Smith, William A. Suk, Bindu Lohani, Alan Krupnick, Jo Ivey Boufford, Bruce P. Lanphear, Alexander S Preker, Robert G. Arnold, Stephan Bose-O'Reilly, Roberto Bertollini, Patrick N. Breysse, Onno C. P. van Schayck, Johanita D Ndahimananjara, Peter D. Sly, David Hanrahan, Michael Greenstone, Karen V Mathiasen, Carlos Salinas, Thomas C. Chiles, Frederica P. Perera, Achim Steiner, Awa M Coll-Seck, Maureen A. McTeer, Olusoji Adeyi, Karti Sandilya, Leona D. Samson, Johan Rockström, Abdoulaye Bibi Baldé, Nereus J R Acosta, Gautam N. Yadama, David J. Hunter, Keith Martin, Richard Fuller, Janez Potočnik, Maureen L. Cropper, Ma Zhong, Andy Haines, Mukesh Khare, Chulabhorn Mahidol, Kandeh K. Yumkella, Julius N. Fobil, Valentin Fuster, Philip J. Landrigan, Christopher J L Murray, Jairam Ramesh, Richard B. Stewart, and Niladri Basu
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Male ,International Cooperation ,TOXIC-WASTE SITES ,Commission ,010501 environmental sciences ,Global Health ,01 natural sciences ,0302 clinical medicine ,Cost of Illness ,Residence Characteristics ,Cost of illness ,Soil Pollutants ,Water Pollutants ,030212 general & internal medicine ,Child ,media_common ,Air Pollutants ,Ambient air pollution ,BISPHENOL-A EXPOSURE ,Health Policy ,Middle income countries ,General Medicine ,Middle Aged ,LONG-TERM EXPOSURE ,Geography ,Child, Preschool ,Female ,BLOOD LEAD LEVELS ,Environmental Health ,Pollution ,Adult ,Conservation of Natural Resources ,Adolescent ,media_common.quotation_subject ,MEDLINE ,ENVIRONMENTAL KUZNETS CURVE ,World Health Organization ,03 medical and health sciences ,Young Adult ,Age Distribution ,MIDDLE-INCOME COUNTRIES ,Environmental health ,Humans ,Noncommunicable Diseases ,Poverty ,Health policy ,Occupational Health ,0105 earth and related environmental sciences ,Aged ,Mortality, Premature ,Infant, Newborn ,Infant ,Health Status Disparities ,GLOBAL BURDEN ,PARTICULATE MATTER EXPOSURE ,AMBIENT AIR-POLLUTION ,EMERGENCY-ROOM VISITS ,Chronic Disease ,Environmental Pollution - Abstract
Pollution is the largest environmental cause of disease and premature death in the world today. Diseases caused by pollution were responsible for an estimated 9 million premature deaths in 2015—16% of all deaths worldwide—three times more deaths than from AIDS, tuberculosis, and malaria combined and 15 times more than from all wars and other forms of violence. In the most severely affected countries, pollution-related disease is responsible for more than one death in four.
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- 2017
8. Reinvesting in health post-2015
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Jasmine Whitbread, Richard Sezibera, Rasmus Helveg Petersen, Hillevi Engström, Joy Phumaphi, Lambert Grijns, Anarfi Asamoa-Baah, Ursula Müller, Ariel Pablos-Mendes, Lola Dare, John E Lange, Anders Nordström, Ramanan Laxminarayan, Awa M. Coll-Seck, Pe Thet Khin, and Graça Machel
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Text mining ,business.industry ,Political science ,General Medicine ,business ,Data science - Published
- 2013
9. Characteristics and Presenting Complaints of Outpatients With Undiagnosed HIV Infection
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Nancy B. Kiviat, Papa Salif Sow, Stephen E. Hawes, Martin W. McIntosh, Awa M. Coll-Seck, Aissatou Diop, Cathy W. Critchlow, Geoffrey S. Gottlieb, Alison K. Starling, and Mame B. Diouf
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Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Human immunodeficiency virus (HIV) ,HIV Infections ,Hiv testing ,medicine.disease_cause ,Ambulatory Care Facilities ,Acquired immunodeficiency syndrome (AIDS) ,Immunopathology ,medicine ,Humans ,Pharmacology (medical) ,Sida ,Aged ,biology ,business.industry ,Patient Selection ,Middle Aged ,medicine.disease ,biology.organism_classification ,Senegal ,Cross-Sectional Studies ,Infectious Diseases ,HIV-2 ,Ambulatory ,Immunology ,Lentivirus ,HIV-1 ,Female ,Viral disease ,business - Abstract
HIV testing of individuals presenting to outpatient medical clinics has generally been based upon a selection system, with testing limited to those having signs or symptoms previously found associated with HIV-1 infection among hospitalized patients. However, little is known about the efficacy of this approach, particularly in Africa. Among patients presenting to a large outpatient infectious disease clinic in Dakar, Senegal, the utility of using specific demographic and behavioral characteristics and individual presenting complaints to identify individuals with previously undiagnosed HIV-1 or HIV-2 infection was examined. Using a simple statistical approach, a composite screening rule was estimated to identify subjects with the highest probability of testing HIV positive, ie, patients who would most benefit from HIV testing. Using the presenting complaint allows identification of 83% of HIV-infected women by testing only 35% of women presenting to the clinic. Similarly, using the presenting complaint and various demographic and behavioral characteristics, it was possible to identify 84% of HIV-infected men by screening 40% of men presenting to the clinic. This study suggests that this method might provide a cost-effective approach that permits limited screening resources to be spent in a way that maximizes individual and societal benefit.
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- 2004
10. Molecular Epidemiology of Dual HIV-1/HIV-2 Seropositive Adults from Senegal, West Africa
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Cathy W. Critchlow, Nancy B. Kiviat, Geoffrey S. Gottlieb, James I. Mullins, Awa M. Coll-Seck, Stephen E. Hawes, Marcel E. Curlin, Ibra Ndoye, and Papa Salif Sow
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Adult ,Male ,Adolescent ,Molecular Sequence Data ,Immunology ,Genes, env ,Polymerase Chain Reaction ,Virus ,Cohort Studies ,Acquired immunodeficiency syndrome (AIDS) ,Seroepidemiologic Studies ,Sequence Homology, Nucleic Acid ,Virology ,Immunopathology ,HIV Seropositivity ,medicine ,Humans ,Sida ,Phylogeny ,Molecular epidemiology ,biology ,virus diseases ,Middle Aged ,biology.organism_classification ,medicine.disease ,Genes, gag ,Senegal ,Infectious Diseases ,DNA, Viral ,HIV-2 ,Lentivirus ,Cohort ,HIV-1 ,Female ,Viral disease - Abstract
Dual infection with HIV-1 and HIV-2 can occur in locales where these viruses co-circulate, most commonly in West Africa. Although dual seropositivity is common in this region, the true rate of dual infection remains unclear. In addition, whether unique HIV-1 subtypes are circulating in dually infected individuals is unknown. A cohort of 47 HIV-1 and HIV-2 dually seropositive individuals from Senegal, West Africa was screened for the presence of HIV-1 and HIV-2 gag and env PBMC viral DNA sequences using PCR. Of the 47 dual HIV-1/HIV-2 seropositive individuals tested, 19 (40.4%) had infection with both HIV-1 and HIV-2 confirmed by genetic sequence analysis, whereas only HIV-1 or HIV-2 was confirmed in 17 (36.2%) or 9 (19.1%), respectively. The majority of HIV-1 subtypes found were CRF-02 and A, although subtypes D, C, G, J and B were also found, reflecting the subtypes known to be circulating in Senegal. There was no significant difference in HIV-1 subtype distribution between individuals with confirmed dual infection and patients in this study with dual seropositivity but lacking HIV-2, or with HIV-1 infected patients within the general population in Senegal, although the study was underpowered to detect anything but large differences. The prevalence of HIV-1/HIV-2 dual infection appears to be significantly less than that of dually seropositive individuals and this likely reflects cross-reactive serology. The common HIV-1 subtypes prevalent in West Africa (CRF-02 and subtype A) have a similar distribution to those found in our cohort of dually infected and dually seropositive subjects.
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- 2003
11. Prevalence and risk factors of cervicovaginal HIV shedding among HIV-1 and HIV-2 infected women in Dakar, Senegal
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D. Henzel, Claire Mulanga-Kabeya, Karim Seck, Serge Tempesta, Ibrahima Ndoye, Ngone Samb, Eric Delaporte, Souleymane Mboup, Awa M. Coll-Seck, and Papa Salif Sow
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Adult ,medicine.medical_specialty ,Population ,Cervix Uteri ,Dermatology ,Acquired immunodeficiency syndrome (AIDS) ,Risk Factors ,parasitic diseases ,HIV Seropositivity ,Odds Ratio ,Prevalence ,medicine ,Humans ,Viral shedding ,Risk factor ,education ,Cervix ,education.field_of_study ,Obstetrics ,business.industry ,virus diseases ,Original Articles ,Odds ratio ,medicine.disease ,Senegal ,Virus Shedding ,Cross-Sectional Studies ,Infectious Diseases ,medicine.anatomical_structure ,HIV-2 ,Vagina ,Immunology ,Disease Progression ,HIV-1 ,RNA, Viral ,Regression Analysis ,Female ,Viral disease ,business ,Viral load - Abstract
Objectives: To assess the risk determinants and prevalence of cervicovaginal shedding of HIV-1 and HIV-2 among women in Dakar, Senegal. Methods: We conducted a cross sectional study of 153 HIV seropositive female sex workers (FSW) and another 142 HIV seropositive women attending an infectious diseases unit, based on an interview, physical examination, and laboratory screening for major sexually transmitted infections (STI). Cervicovaginal lavage fluid was tested for HIV-RNA by means of nested PCR. Links between cervicovaginal shedding of HIV-1 and HIV-2 and sociodemographic, clinical, and laboratory variables were identified by using odd ratios and 95% confidence intervals. Logistic regression analysis was used to identify independent links with HIV shedding. Results: The detection rate of HIV-RNA in cervicovaginal lavage fluid was low among FSW, with no difference between HIV-1 (7/90: 8%) and HIV-2 (3/48: 6%). The rate was far higher among the other women (41%, 48/117; 33%, 7/21 for HIV-1 and HIV-2, respectively). In multivariate analysis, high plasma viral load (>40 000 copies/ml) (AOR = 2.4 (1.0–5.6) p = 0.04) and basic vaginal pH (AOR = 2.2 (1.3–3.7) p = 0.002) were independently associated with HIV-1 shedding. For HIV-2 a CD4 count < 200 cells x 106/l was the only factor associated with the shedding of HIV-2 (AOR = 9.0 (0.9–93)). The genital shedding rate was higher with HIV-1 than with HIV-2 (OR = 2.1 (0.9–4.8), but this difference disappeared after adjustment for the CD4+ cell count (AOR = 1.2 (0.5–2.9)). Conclusion: Advanced disease stage and immunosuppression are the major risk determinants for shedding of both HIV-1 and HIV-2. Basic vaginal pH is also a risk determinant for HIV-1 shedding. Key Words: cervicovaginal shedding; HIV; Senegal
- Published
- 2001
12. Universal health coverage and HIV in resource-constrained countries: a critical juncture for research and action
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Ibra Ndoye, Awa M. Coll Seck, Bernard Taverne, Françoise Barré-Sinoussi, Eric Delaporte, and Alice Desclaux
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Program evaluation ,Economic growth ,ANTIRETROVIRAUX ,PROTECTION SOCIALE ,Immunology ,Resource constrained ,Human immunodeficiency virus (HIV) ,MEDLINE ,Developing country ,HIV Infections ,medicine.disease_cause ,ASSURANCE ,PRIX ,PROJET DE RECHERCHE ,Health Services Accessibility ,TRAITEMENT MEDICAL ,ASSURANCE DE SANTE UNIVERSELLE ,Universal Health Insurance ,Environmental health ,medicine ,Immunology and Allergy ,Humans ,SANTE PUBLIQUE ,Developing Countries ,Juncture ,business.industry ,SIDA ,ETUDE REGIONALE ,MEDICAMENT ,ACCES AUX SOINS ,Infectious Diseases ,Action (philosophy) ,Social protection ,Africa ,SYSTEME DE SANTE ,GRATUITE ,business - Published
- 2013
13. Epidemiological factors affecting prognosis of neonatal tetanus in Dakar, Senegal
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Bernard Marcel Diop, Mame Awa Faye, Papa Salif Sow, Salif Badiane, and Awa M. Coll-Seck
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Pregnancy ,Pediatrics ,medicine.medical_specialty ,business.industry ,Epidemiological Factors ,Tetanus ,medicine.disease ,Umbilical cord ,Neonatal tetanus ,medicine.anatomical_structure ,health services administration ,medicine ,University teaching ,business - Abstract
To investigate factors affecting prognosis of neonatal tetanus (NNT), the present study was conducted in the infectious diseases ward of the Dakar University Teaching Hospital from January 1992 to December 1993. One hundred ninety one cases of NNT were collected. According to the questionnaire, the main important epidemiological factors affecting prognosis of NNT are : home delivery, age less than 7 days, cutting and dressing the umbilical cord with nonsterile instruments and lack of tetanus imminuzation during pregnancy.
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- 1994
14. Using systematic screening to increase integration of reproductive health services delivery in Senegal
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Ricardo Vernon, Omar Sarr, Balla Mbacke Mboup, James R. Foreit, Laty G. Ndoye, Cheikh Bamba Diop, Diouratie Sanogo, Colonel Adama Adoye, and Awa M. Coll-Seck
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business.industry ,Environmental health ,Quality of care ,business ,Reproductive health ,Situation analysis - Published
- 2005
15. Increased risk of high-grade cervical squamous intraepithelial lesions and invasive cervical cancer among African women with human immunodeficiency virus type 1 and 2 infections
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Mame B. Diouf, Jane Kuypers, Nancy B. Kiviat, Mame Awa Faye Niang, Papa Salif Sow, B. Dembele, Awa M. Coll-Seck, Kasse Aa, Stephen E. Hawes, Papa Toure, Cathy W. Critchlow, and Aissatou Diop
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Adult ,medicine.medical_specialty ,Population ,Uterine Cervical Neoplasms ,HIV Infections ,Cervix Uteri ,Acquired immunodeficiency syndrome (AIDS) ,Risk Factors ,Internal medicine ,medicine ,Immunology and Allergy ,Outpatient clinic ,Humans ,Papillomaviridae ,education ,Cervical cancer ,education.field_of_study ,biology ,AIDS-Related Opportunistic Infections ,business.industry ,Papillomavirus Infections ,HPV infection ,virus diseases ,Viral Load ,biology.organism_classification ,medicine.disease ,CD4 Lymphocyte Count ,Central African Republic ,Squamous intraepithelial lesion ,Tumor Virus Infections ,Infectious Diseases ,Immunology ,HIV-2 ,Carcinoma, Squamous Cell ,HIV-1 ,RNA, Viral ,Female ,business ,Viral load - Abstract
To assess the risk of prevalent high-grade cervical squamous intraepithelial lesions (HSILs) or invasive cervical cancer (ICC) associated with human immunodeficiency virus (HIV) type 1, HIV-2, and human papillomavirus (HPV) infections, HIV load, and CD4 cell count, we studied 4119 women attending an outpatient clinic in Senegal. HIV infection was associated with increased rates of cervical infection with high-risk HPVs. Among women infected with high-risk HPVs, those with HIV-1 (odds ratio [OR], 2.2; 95% confidence interval [CI], 1.0-4.8), HIV-2 (OR, 6.0; 95% CI, 2.1-17.1), or dual HIV infection (OR, 8.0; 95% CI, 2.0-31.5) were more likely to have HSILs or ICC diagnosed than were HIV-negative women; this association was not observed among women not infected with high-risk HPVs. Among women with HIV, higher HIV plasma RNA loads and lower CD4 cell counts were associated with high-risk HPV infection and degree of cervical abnormality. Furthermore, HIV-2-positive women were more likely to have HSILs (OR, 3.3; 95% CI, 0.9-12.4) or ICC (OR, 7.9; 95% CI, 1.1-57) than were HIV-1-positive women.
- Published
- 2002
16. Equal plasma viral loads predict a similar rate of CD4+ T cell decline in human immunodeficiency virus (HIV) type 1- and HIV-2-infected individuals from Senegal, West Africa
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Aissatou Diop, James I. Mullins, Awa M. Coll-Seck, Ibra Ndoye, Richard Respess, Nancy B. Kiviat, Stephen E. Hawes, Cathy W. Critchlow, Mary W. Redman, Mame A. Faye-Niang, Geoffrey S. Gottlieb, Jane Kuypers, and Papa Salif Sow
- Subjects
Adult ,Male ,T cell ,HIV Infections ,Virus ,Acquired immunodeficiency syndrome (AIDS) ,Predictive Value of Tests ,medicine ,Immunology and Allergy ,Humans ,Viremia ,Sida ,biology ,virus diseases ,Middle Aged ,Viral Load ,biology.organism_classification ,medicine.disease ,Virology ,Senegal ,CD4 Lymphocyte Count ,Infectious Diseases ,medicine.anatomical_structure ,Lentivirus ,Cohort ,Immunology ,DNA, Viral ,HIV-2 ,HIV-1 ,RNA, Viral ,Female ,Viral disease ,Viral load - Abstract
Human immunodeficiency virus (HIV) type 2 infection is characterized by slower disease progression to acquired immunodeficiency syndrome than results from HIV-1 infection. To better understand the biological factors underlying the different natural histories of infection with these 2 retroviruses, we examined the relationship between HIV RNA and DNA levels and the rate of CD4(+) T cell decline among 472 HIV-1- and 114 HIV-2-infected individuals from Senegal. The annual rate of CD4(+) T cell decline in the HIV-2 cohort was approximately one-fourth that seen in the HIV-1 cohort. However, when the analysis was adjusted for baseline plasma HIV RNA level, the rates of CD4(+) T cell decline per year for the HIV-1 and HIV-2 cohorts were similar (a rate increase of approximately 4% per year for each increase in viral load of 1 log(10) copies/mL). Therefore, plasma HIV load is predictive of the rate of CD4(+) T cell decline over time, and the correlation between viral load and the rate of decline appears to be similar among all HIV-infected individuals, regardless of whether they harbor HIV-1 or HIV-2.
- Published
- 2001
17. Cost-effective diagnosis of HIV-1 and HIV-2 by recombinant-expressed env peptide (566/996) dot-blot analysis
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Aissatou Guèye-Ndiaye, Raymond J. Clark, Kenneth P. Samuel, Anta N. Ndour-Sarr, Amadou Ouangré, Lassana Sangaré, Souleymane Mboup, Richard G. Marlink, Takis S. Papas, Rachel H. Child, Awa M. Coll-Seck, Myron E. Essex, and Phyllis J. Kanki
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Sexually transmitted disease ,Cost effectiveness ,Cost-Benefit Analysis ,Immunology ,Immunoblotting ,Dot blot ,Peptide ,HIV Infections ,Sensitivity and Specificity ,Epitope ,law.invention ,Viral envelope ,Antigen ,law ,Immunology and Allergy ,Medicine ,Humans ,chemistry.chemical_classification ,business.industry ,virus diseases ,AIDS Serodiagnosis ,Gene Products, env ,Virology ,Recombinant Proteins ,Infectious Diseases ,chemistry ,HIV-2 ,Recombinant DNA ,HIV-1 ,business - Abstract
This study sought to characterize the recombinant env peptides 566 )HIV-1) any 996 (HIV-2) for their ability to serodiagnose HIV-1 and HIV-2 infection to develop a cost-effective dot-blot format for these peptides and to evaluate its performance in a developing country laboratory. The recombinant env peptides were evaluated using a select panel (n=327) with known serostatus from geographically diverse areas. A dot-blot assay was developed and tested on a second set of immunoblotted sera (n=331) and further evaluated in the field on a third set of sera (n=2718) from study populations. All sera were evaluated by immunoblot with both HIV-1 and HIV-2 viral lysates. The recombinant env peptides were characterized in immunoblot assay before the development of the dot-blot assay. The results were as follows. The 566 (HIV-1) peptide showed 100% sensitivity and specificity. The 996 (HIV-2) peptide performed similarly but showed the presence of HIV-1 cross-reactive epitopes. When the 2 env peptides were used together there was high specificity and sensitivity for detecting HIV-positive sera in both immunoblot and dot-blot formats. The dot-blot assay performed in the field showed slightly lower specificity and sensitivity for HIV diagnosis. The relative cost of this assay combined with noncommercial immunoblot confirmation was 10-fold lower than conventional commercial assays. The authors concluded that the 566 and 996 env peptides are appropriate antigens for HIV serotype diagnosis. A dot-blot assay using these peptides may be a useful cost-effective method for HIV diagnosis applicable in developing country laboratories. (authors modified)
- Published
- 1993
18. Molecular Epidemiology of Dual HIV-1/HIV-2 Seropositive Adults from Senegal, West Africa.
- Author
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Geoffrey S. Gottlieb, Papa Salif Sow, Stephen E. Hawes, Ibra Ndoye, Awa M. Coll-Seck, Marcel E. Curlin, Cathy W. Critchlow, Nancy B. Kiviat, and James I. Mullins
- Published
- 2003
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