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A recent study conducted in Daejeon, South Korea, focused on utilizing a recombinant Newcastle disease virus (rNDV) vector expressing the human PTEN gene to target glioblastoma (GBM) cells. The research aimed to restore PTEN expression in GBM cells, which is often associated with poor prognosis. Results showed that the rNDV-PTEN treatment increased PTEN protein expression, reduced cell proliferation and migration, and induced apoptosis in GBM cells. The study concluded that rNDV-PTEN could be a promising therapeutic agent for GBM, especially for patients with PTEN deficiency. [Extracted from the article]

A study conducted by the High Institute for Research and Education in Transfusion Medicine in Tehran, Iran, explored the synergistic anti-tumor effects of Newcastle Disease Virus (NDV) and Doxorubicin in treating triple-negative breast cancer (TNBC). The research involved in vitro and in vivo experiments, demonstrating that the combination of NDV and Doxorubicin effectively inhibited tumor progression and reduced the viability of breast cancer cells. The study suggests that this combined therapeutic strategy has the potential to enhance breast cancer therapy outcomes while potentially reducing the toxic side effects of chemotherapy. [Extracted from the article]

The Indian Institute of Technology Guwahati conducted research on the antiviral properties of karanjin, derived from Pongamia pinnata seeds, against the Newcastle disease virus (NDV). The study found that karanjin significantly reduced NDV replication and showed strong binding with the HN protein of NDV. This research provides valuable insights for potential therapeutic applications of karanjin against viral infections. For more information, readers can refer to the published article in Virology. [Extracted from the article]

A recent study conducted by the University of Tehran in Iran focused on assessing different antigens and inactivators for the hemagglutination inhibition (HI) assay of the Newcastle Disease Virus, a significant threat to the global poultry industry. The research found that BEA-inactivated antigens, particularly the B vaccine, exhibited higher mean titers in the HA assay compared to formalin-inactivated antigens. The study recommended the use of Hitchner pathotype antigens, specifically the B vaccine, along with BEA as the preferred inactivator for more accurate serological testing in controlling and preventing Newcastle disease in poultry. [Extracted from the article]

University Putra Malaysia conducted research on the detection of Newcastle Disease Virus (NDV) using a voltammetric immunosensor. The study developed a method involving the immobilization of anti-NDV on a polyethylene glycol (PEG)-containing self-assembled monolayer (SAM) on a gold electrode. The research concluded that this electrochemical detection method could serve as an alternative to conventional NDV detection methods, offering a simple, fast, and less laborious approach. The study was peer-reviewed and conducted by researchers including Amir Syahir Amir Hamzah and Mohamad Farid Abd Muain from the Nanobiotechnology Research Group at University Putra Malaysia. [Extracted from the article]

The Hubei Academy of Agricultural Sciences in Wuhan, China, conducted research on a recombinant Newcastle disease virus expressing the gB protein of infectious laryngotracheitis virus as a bivalent in ovo vaccine. The study found that the vaccine strain was safe and highly immunogenic, inducing effective antibody responses and providing complete protection against virulent Newcastle disease and infectious laryngotracheitis challenges. This research suggests that the vaccine candidate could be a valuable tool in combating these avian respiratory diseases in the poultry industry. [Extracted from the article]

A recent study conducted at Tottori University in Japan focused on the Newcastle Disease Virus (NDV) in ducks, comparing the pathogenicity of different NDV strains. The research found that ducks inoculated with the d5a20b NDV strain exhibited more severe neurological signs, lymphoid depletion in immune organs, and nonsuppurative encephalitis compared to ducks inoculated with the 9a5b strain. The study concluded that the immune organs, brain, and pancreas were significant targets of the d5a20b NDV infection in ducks. For more information, readers can refer to the article "Comparative and experimental pathology of passaged Newcastle disease virus isolates in ducks" published in Veterinary Pathology. [Extracted from the article]

A recent study conducted at the U.S. National Poultry Research Center in Athens, Georgia, focused on the duration of infectivity of highly pathogenic avian influenza virus (HPAIV) and Newcastle disease virus (NDV) in dried ornithologic study skins. The research aimed to assess the risk of contamination of study skins with these viruses and found that viable virus could not be detected in either tissue type after 4 weeks of drying. This study provides valuable insights for researchers working with avian specimens and highlights the importance of proper handling and treatment of study skins to mitigate disease transmission risks. [Extracted from the article]

Researchers at Yangzhou University in the People's Republic of China have conducted a study on the entry of Newcastle disease virus (NDV) into host cells, focusing on the interplay between viral and host factors. NDV, which causes Newcastle disease in poultry, has potential applications in developing vaccines and cancer therapy. The study highlights the mechanisms of NDV entry into cells, identifies factors that regulate viral binding, and discusses future research directions. This peer-reviewed research provides valuable insights into NDV biology and potential therapeutic applications. [Extracted from the article]

Researchers have submitted a patent application for a pharmaceutical composition of mung bean hull extract with antiviral properties. The extract is obtained by soaking and extracting mung bean hulls with alcohol, and has shown potential to inhibit various viruses, including influenza and Newcastle disease virus. This innovative approach combines traditional Chinese medicine with modern technology to develop a promising antiviral treatment. [Extracted from the article]

A recent study conducted by the National University of San Marcos in Lima, Peru, focused on the Newcastle Disease Virus (NDV) in domestic birds in Peru. The research identified the cocirculation of multiple NDV genotypes, including highly virulent genotypes XII and VII, along with nonvirulent forms like genotypes I and II. The study highlighted the potential role of gamecocks as a source of virulent NDV strains and emphasized the importance of genetic analysis for vaccine adaptation to combat the evolving viruses. This research underscores the significance of understanding and monitoring NDV in domestic bird populations in Peru to prevent outbreaks in poultry farms. [Extracted from the article]

A recent study conducted at Islamic Azad University explored the potential of using Newcastle disease virus (NDV) to enhance the antitumor efficacy of Doxorubicin in a mouse model of cervical cancer. The research found that the combination therapy significantly improved survival rates and slowed tumor progression compared to the control group. The study suggests that NDV could serve as an adjunct therapy alongside chemotherapy for cervical cancer treatment. [Extracted from the article]

Researchers at Henan University of Science and Technology have enhanced the oncolytic potential of the Newcastle Disease Virus (NDV) by modifying its F protein cleavage site. The recombinant NDV LaSota strain, rLaSota-BC-RFP, showed increased infectivity and tumor cell suppression in murine melanoma cells. This modification also led to improved tumor growth inhibition, survival rates, and immune responses in mice, suggesting that rLaSota-BC-RFP could be a promising oncolytic viral vector for cancer gene therapy. The study highlights the potential of using engineered viruses to enhance cancer treatment outcomes. [Extracted from the article]

A recent study conducted at Mansoura University in Egypt explored the potential protective effects of Glycyrrhiza glabra (G. glabra) against the Newcastle disease virus (NDV) in chickens. The research involved treating 1-day-old SPF chicks with G. glabra extract before and after viral challenge, resulting in a significant decrease in clinical symptoms, mortality rates, and viral shedding compared to untreated chicks. The study concluded that G. glabra extract could effectively mitigate the debilitating effects of Newcastle disease in chickens. For more information, readers can refer to the article "Mitigating Impact of Glycyrrhiza Glabra on Virulent Newcastle Disease Virus Challenge in Chickens: Clinical Studies, Histopathological Alterations, and Molecular Docking" published in Veterinary Research Communications. [Extracted from the article]

A recent study conducted by researchers at MAHSA University in Selangor, Malaysia, explored the potential of Newcastle Disease Virus (NDV) as a treatment for leukemia. The researchers used scanning and transmission electron microscopy techniques to study the effects of NDV strain AF2240 on a leukemia cell line. They found that NDV significantly altered cell morphology, reduced cell viability, and induced early apoptosis in the leukemia cells. These findings provide new insights into the mechanism of action of NDV virotherapy and could potentially lead to the development of more effective treatments for leukemia. [Extracted from the article]

A recent study conducted by researchers at the University of Baghdad in Iraq explores the potential of combining oncolytic virotherapy and photodynamic therapy (PDT) as a dual approach for breast cancer treatment. The researchers found that the integration of the attenuated NDV-AMHA1 strain with PDT had a synergistic killing effect on breast cancer cells in vitro. This suggests that this combination therapy could be a promising strategy to overcome breast cancer. Further research and clinical trials are needed to validate these findings. [Extracted from the article]

A recent study conducted by researchers at Yangzhou University in China has revealed new findings on cancer gene therapy using Newcastle disease virus (NDV). The study focused on the role of the Endosomal Sorting Complex Required for Transport (ESCRT) machinery in regulating NDV replication in tumor cells. The researchers found that knockdown of certain ESCRT components, particularly HRS, significantly impaired NDV replication and viral budding in HeLa cells. These findings provide valuable insights for the development of NDV-based oncolytic therapies. [Extracted from the article]

New research conducted by the Indian Council of Agricultural Research (ICAR) Directorate of Poultry Research in Telangana, India, focuses on the Newcastle Disease Virus (NDV) and its impact on the poultry industry. The study analyzed the lung transcriptome data of two chicken breeds, Leghorn and Fayoumi, known for their differences in resistance to NDV. The researchers identified genes and long non-coding RNAs (lncRNAs) that play a role in the differential immune response between the two breeds. The study highlights the crucial role of lncRNAs in the immune response to NDV and suggests that further research is needed to understand the biological mechanisms behind the regulation of immune-related genes. [Extracted from the article]

A study conducted by the University of the Punjab in Lahore, Pakistan, investigated the potential toxicity and safety concerns of transgenic maize seeds expressing immunogenic F and HN protein genes against Newcastle disease virus (NDV). The study involved feeding Sprague-Dawley rats with transgenic maize seeds for 90 days and assessing various parameters. The results showed no significant differences between the control and treatment groups in terms of overall appearance, feed consumption, body weight, organ weight, hematological parameters, serum chemistry, histopathology, and gross appearance of tissues. The study suggests that the consumption of transgenic maize seeds did not lead to any adverse effects or toxicological issues in rats. However, further research is needed to evaluate the safety and potential applications of transgenic edible vaccines in humans or other animals. [Extracted from the article]

A recent report from COMSATS University Islamabad in Pakistan explores the Newcastle Disease Virus (NDV), a highly infectious viral disease that affects birds, particularly domestic poultry. The researchers focused on the Hemagglutinin-Neuraminidase (HN) protein of NDV as a potential therapeutic target. Using computational modeling and molecular dynamic simulation, they identified natural molecules that can inhibit the HN protein. The study identified a potential HN inhibitor, A1 (ZINC05223166), which may be further validated through clinical trials. This research provides valuable insights for the development of antiviral agents targeting NDV. [Extracted from the article]

A report from the Education and Extension Organization (AREEO) in Karaj, Iran discusses the findings of a study on Newcastle Disease Virus (NDV), a single-stranded negative-sense RNA virus that affects domestic poultry and other bird species. The study focused on developing a process to concentrate and purify the NDV V4 strain using downstream processing techniques. The results showed successful purification of the virus particles, removal of ovalbumin, and positive immunogenicity of the prepared antigens. The researchers suggest that this method could be used on a semi-industrial scale for vaccine production. [Extracted from the article]

A report from Northwest A&F University in Shaanxi, China discusses research on Newcastle Disease Virus (NDV), a virus that causes economic losses in poultry globally. The study evaluated 36 canthin-6-one analogs as potential antiviral agents against NDV. Eight compounds showed inhibitory effects on NDV replication, with one analog (16) demonstrating the strongest anti-NDV activity and minimal cytotoxicity. The research found that analog 16 inhibited viral entry by suppressing the Akt pathway and also inhibited the NDV-activated ERK pathway, promoting the expression of interferon-related genes. The study suggests that canthin-6-one analogs have potential as antiviral agents for NDV. [Extracted from the article]

A recent report from Anna University in Chennai, India, discusses the Newcastle Disease Virus (NDV), which causes significant economic losses in the poultry industry worldwide. The researchers conducted a transcriptome profiling study to understand the molecular mechanisms of virus-host interactions during the first 24 hours of infection with NDV. They found an increase in the expression of genes related to the MAPK signaling pathway, which may aid viral multiplication while hindering the host's immune response. This research provides initial insights into the early responses of host cells to NDV infection. [Extracted from the article]

A study conducted by the Animal Health Research Institute in Egypt focused on the Newcastle Disease Virus (NDV) in commercial broiler chickens in northern Egypt. The research aimed to isolate and genotype the virus, as well as compare it to the vaccines currently in use. The results showed that the circulating NDV in vaccinated chicken flocks in Egypt belonged to genotypes VII.1.1 and XXI.1.1. The study provides valuable information on the characteristics of NDV in northern Egypt. [Extracted from the article]

A recent study conducted by the Razi Vaccine and Serum Research Institute in Karaj, Iran, has found that Newcastle disease (ND) is a highly contagious bird disease that affects both commercial poultry and free-living birds. The study identified three different genotypes of the Newcastle Disease Virus (NDV) in captive bird species at a public bird garden in Tehran. The presence of these different genotypes highlights the need for stricter biosecurity measures to prevent the spread of the disease. The study also suggests that the spillover of vaccine strains from commercial poultry flocks to wild birds may contribute to the presence of certain genotypes. [Extracted from the article]

A report from Shiraz University in Iran discusses the potential use of olive leaf extract (OLE) and the Newcastle disease virus (NDV) as a combined treatment for cervical cancer. The researchers encapsulated OLE in lipid nanoparticles to enhance stability and targeted delivery. In vitro experiments showed that the combination of OLE-loaded nanoparticles and NDV had a significantly higher cytotoxic effect on cervical cancer cells compared to normal cells. The study suggests that this combination therapy has the potential to be a safer and more effective alternative treatment for cervical cancer. [Extracted from the article]

A recent study conducted by researchers at Universitas Nusa Cendana has provided new insights into the Newcastle Disease Virus (NDV) and its impact on chickens. The study focused on the differences between two vaccines, one targeting NDV genotype II (GII-vacc) and the other targeting genotype VII (GVII-vacc). The research found that GVII-vacc affected the immune response by downregulating neuroinflammation and enhancing a synaptogenesis pathway, suggesting a neurotrophic effect. On the other hand, GII-vacc inhibited apoptosis but did not affect the same synaptogenesis pathway. The findings suggest that the application of GVII-vacc should be considered in countries where GVII is the leading cause of NDV outbreaks, and the molecular signatures identified in the study may be used to develop new vaccines. [Extracted from the article]

Researchers from Jimma University in Ethiopia have conducted a study on Newcastle disease virus (NDV), a viral infection that affects chickens. Despite vaccination efforts, outbreaks of NDV have been increasing in Ethiopia. The researchers collected tissue samples from infected chickens on commercial farms and conducted genetic analysis to determine the genotype and virulence of the NDV strains. They found that the circulating NDV strains were distinct from the locally used vaccine strains, which may explain the low level of protection provided by the vaccines. Further studies are needed to better understand the different genotypes of NDV in different production systems. [Extracted from the article]

A study conducted by the University of Tabriz in Iran explores the potential of dietary arginine supplementation to mitigate the adverse effects of Newcastle disease (ND) in broiler chicks. ND is a significant challenge in the poultry industry, leading to increased mortality rates, compromised growth, weakened immunity, and elevated inflammation. The study found that dietary arginine supplementation effectively counteracted the negative impacts of ND on growth, immune responses, and proinflammatory cytokine levels. The researchers recommend supplementing with arginine at levels exceeding conventional dietary recommendations to alleviate the detrimental consequences of ND effectively. [Extracted from the article]

A recent report from the Department of Livestock Services in Bangladesh has characterized the dominant strain (G-VII) of Newcastle disease viruses (NDV) isolated from commercial chickens during recent outbreaks. The study found that NDV-GVII is prevalent in commercial poultry farms in Bangladesh and is causing severe economic consequences for the chicken industry. The isolated NDV strains were identified as velogenic strains and exhibited high virulence. Phylogenetic analysis showed that the recent NDV isolates belong to genotype VII and have a high similarity with isolates from Bangladesh, Iran, and India. [Extracted from the article]

A study conducted by researchers at the University of Adelaide in Australia explores the pathogenesis of virulent strains of the Newcastle disease virus (NDV) in experimentally infected birds. The study reveals that bursal atrophy and extensive depletion of lymphoid tissues are the predominant and consistent lesions observed. The researchers found that bursal atrophy is linked to a non-apoptotic programmed cell death pathway known as "necroptosis," while necrosis predominantly contributes to lymphoid depletion in the spleen. The study suggests that the understanding of necroptosis in NDV-infected chickens could provide insights into other paramyxoviral diseases, such as human measles. [Extracted from the article]

A patent has been issued for Newcastle disease viruses (NDV) and their uses in treating cancer. The chimeric NDV described in the patent contains a packaged genome that encodes interleukin-12 (IL-12) or a derivative thereof. The IL-12 transgene is expressed by cells infected with the chimeric NDV and has shown robust antitumor activity in combination with an antagonist of PD-1. The methods described in the patent involve administering the chimeric NDV and the PD-1 antagonist to treat cancer. The patent was filed by inventors from the Icahn School of Medicine at Mount Sinai and was published online on July 23, 2024. [Extracted from the article]

A recent report from the Affiliated People's Hospital of Jiangsu University discusses research on the use of recombinant Newcastle disease virus (rL-RVG) to induce ferroptosis in gastric cancer cells. The study found that rL-RVG treatment significantly decreased the survival rate of gastric cancer cells and inhibited their migration and invasion abilities. The researchers also observed a decrease in the expression levels of Nrf2, GCLC, SLC7A11, and GPX4 proteins, as well as an increase in the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) in the virus treatment groups. The findings suggest that rL-RVG can induce ferroptosis in gastric cancer cells through the Nrf2-GCLC-GPX4 pathway, potentially inhibiting tumor growth. [Extracted from the article]

A recent study conducted at King Abdulaziz University in Jeddah, Saudi Arabia, explored the potential of Newcastle disease virus (NDV) as a treatment for colon cancer. The researchers found that NDV demonstrated oncolytic potential, effectively killing cancer cells in vitro and in tumor-induced mice. The study also revealed an immune response associated with the therapeutic effects of NDV, including elevated levels of certain immune markers and reduced expression of IL-10. This research contributes to the field of cancer gene therapy and highlights the potential of NDV as a treatment option for colon cancer. [Extracted from the article]

A recent study conducted at Yangzhou University in China has found that Newcastle disease virus (NDV)-vectored H7N9 avian influenza vaccines are effective in controlling the H7N9 subtype avian influenza virus. The vaccines elicit high levels of hemagglutinin (HA)-binding IgG antibodies in chickens, which provide protection against H7N9 virus infection. The study also identified specific epitopes in the HA of the H7N9 virus that are recognized by the immune serum induced by the vaccines. The findings suggest that the antibodies induced by the NDV-vectored H7N9 vaccines can activate the complement system, providing a potential benefit for H7N9 vaccine design. [Extracted from the article]