1. [Pneumonia due to adenovirus type 7: a case report in a healthy infant]
- Author
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Odièvre, M.-H., Danékova, N., Picard, C., Mesples, B., Bencheikha, Z., Avran, D., De Blic, J., Leruez-Ville, M., Parez, N., Danone Research, Groupe DANONE, Infections à Vih, Réservoirs, Pharmacologie des Antirétroviraux et Prévention de la Transmission Mère Enfant, Université Paris Descartes - Paris 5 (UPD5), Laboratoire de Virologie [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Pierre et Marie Curie - Paris 6 (UPMC), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 ( UPD5 ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Université Pierre et Marie Curie - Paris 6 ( UPMC ), and Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Necker - Enfants Malades [AP-HP]
- Subjects
Male ,[CHIM.ORGA]Chemical Sciences/Organic chemistry ,Adenoviruses, Human ,Pneumonia, Viral ,Infant ,Macrophage Activation ,Prognosis ,Polymerase Chain Reaction ,Lymphohistiocytosis, Hemophagocytic ,Anti-Bacterial Agents ,Adenovirus Infections, Human ,[ CHIM.ORGA ] Chemical Sciences/Organic chemistry ,Humans ,Drug Therapy, Combination ,Immunocompetence - Abstract
International audience; A 15-month-old boy treated with amoxicillin and clavulanic acid therapy for 8 days was admitted for persistent gastroenteritis and fever. He received ceftriaxone for pneumonia modified on day 4 for cefotaxime and josamycin due to extension of alveolar lesions. On day 7, persistent fever and worsened respiratory distress led to addition of rifampicin. The child was then admitted to an intensive care unit. A hemophagocytic syndrome was suspected based on clinical signs and laboratory findings and confirmed by cytological examination of bone marrow. Adenovirus type 7 was identified by polymerase chain reaction and culture of bronchoalveolar fluid. Prognosis was good within 3 weeks. B and T immunologic evaluations were normal 5 months after the infection. This case of severe adenovirus pneumonia was associated with hemophagocytic syndrome in a child without identified primary immunodeficiency. Adenovirus type 3 and 7 are most frequently responsible for severe or fatal respiratory infections.
- Published
- 2011