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This study employs the Stressor-Strain-Outcome theory and investigates the influence of senior tourist's technostress, travel stains, and their avoidance behaviors towards smart tourism technologies (STTs). Results indicated that four distinct types of smart tourism technostressors have significant impacts on the smart tourism avoidance behaviors of senior tourists, and these direct relationships were mediated by travel anxiety, travel fatigue, and travel technophobia. Furthermore, Smart device literacy moderates the construction of smart tourism avoidance behavior. These findings deepened the understanding of the detrimental effects of STTs among senior tourists, with practical implications for STTs acceptance, development, and sustainability. [ABSTRACT FROM AUTHOR]

To identify the range of evidence for relationships between psychological factors using the Fear Avoidance Model (FAM) as a guiding framework and relevant clinical outcomes in adult patients with persisting symptoms after concussion (PSaC), develop a comprehensive understanding of psychological factors that have been identified as predictors of clinical outcomes for PSaC, and contribute to the theoretical framework of the FAM for PSaC. Six databases (CINAHL, Embase, PsycINFO, PubMed, SportDiscus, and Web of Science) were searched by a librarian for empirical and theoretical publications and experimental and quasi-experimental study designs. The literature search was not limited by publication date restrictions. Gray literature, with the exception of doctoral dissertations, was excluded. We included studies in the English language consisting of human participants aged ≥18 years. Articles must have included both outcomes pertaining to PSaC (≥3mo after injury) and psychological constructs. One reviewer extracted data from the resulting studies using a standardized data extraction form designed for this review. Two reviewers independently assessed risk of bias using the Quality in Prognosis Studies tool. This review found numerous psychological constructs, some directly linked to the FAM, that have potential prognostic relationships with PSaC. However, research remains limited and some psychological factors central to FAM were only identified in a small number of studies (catastrophizing, cogniphobia, and avoidance), whereas other psychological factors were studied more extensively (anxiety and depression). There is the need for additional evidence, and this integrative review provides an adaptation of the FAM for PSaC to be used as a guiding preliminary framework for future research. Future research should aim to include psychological factors proposed in this modified FAM to fully understand PSaC. [ABSTRACT FROM AUTHOR]

Background: Illness perceptions (IPs) and avoidance behavior both predict quality of life (QoL) in people with irritable bowel syndrome (IBS). This study examined whether the effects of IPs on QoL are mediated by avoidance behaviors, and whether this mediation is moderated by participant treatment-seeking status. Methods: People with self-reported IBS (n = 253) answered a survey assessing QoL, IPs, avoidance behaviors, and treatment-seeking status. Moderated-mediation analyses investigated the paths from IPs through avoidance behaviors to QoL, with treatment-seeking status entered as a moderator. Results: The final moderated mediation model included the IPs consequences, timeline and emotional representations as independent variables and avoidance behavior and depressive reactions as mediators. This model explained 68.6% of the variance in QoL. Among treatment-seeking participants five significant mediation effects were found, whereas only one significant mediation effect was found among participants who did not report seeking treatment. Conclusions: IPs seem to drive avoidant behavioral responses to IBS symptoms, which in turn predict reductions in QoL. These relationships seem more pronounced among people who seek treatment for their symptoms. In practice, health care practitioners might help improve the QoL of people with IBS by preventing or remedying the development of negative IPs and avoidance behaviors. [ABSTRACT FROM AUTHOR]

The precise organization of pre- and postsynaptic terminals is crucial for normal synaptic function in the brain. In addition to its canonical role as a neurotrophin-3 receptor tyrosine kinase, postsynaptic TrkC promotes excitatory synapse organization through interaction with presynaptic receptor-type tyrosine phosphatase PTPσ. To isolate the synaptic organizer function of TrkC from its role as a neurotrophin-3 receptor, we generated mice carrying TrkC point mutations that selectively abolish PTPσ binding. The excitatory synapses in mutant mice had abnormal synaptic vesicle clustering and postsynaptic density elongation, more silent synapses, and fewer active synapses, which additionally exhibited enhanced basal transmission with impaired release probability. Alongside these phenotypes, we observed aberrant synaptic protein phosphorylation, but no differences in the neurotrophin signaling pathway. Consistent with reports linking these aberrantly phosphorylated proteins to neuropsychiatric disorders, mutant TrkC knock-in mice displayed impaired social responses and increased avoidance behavior. Thus, through its regulation of synaptic protein phosphorylation, the TrkC–PTPσ complex is crucial for the maturation, but not formation, of excitatory synapses in vivo. Synopsis: Interaction between neurotrophin-3 (NT-3) receptor TrkC and phosphatase PTPσ creates an excitatory synaptic organizing complex. Analysis of a new knock-in (KI) mouse model with disrupted TrkC binding to PTPσ, but not to NT-3, reveals the in vivo roles of the TrkC-PTPσ complex in synapse maturation and brain function. Selective loss of TrkC-PTPσ interaction in mice causes abnormal synaptic vesicle clustering and elongation of the postsynaptic density in excitatory synapses. Disruption of TrkC-PTPσ interaction results in mice with more silent and fewer active synapses, the latter displaying enhanced basal synaptic transmission and impaired release probability. The TrkC-PTPσ complex targets a specific set of synaptic proteins for phosphorylation, independent of canonical neurotrophin signaling pathways. TrkC KI mice display specific behavioral abnormalities, including social abnormalities and increased avoidance behavior in unfamiliar anxiogenic conditions. Inhibiting the interaction between postsynaptic TrkC and presynaptic PTPσ results in abnormal excitatory synapse maturation and anxiety-like behaviors in mice. [ABSTRACT FROM AUTHOR]

• Drivers' behaviors in pedestrian-vehicle conflicts were explored in a connected environment. • Connected information and crosswalks positively impact driver behavior with increased safety margins. • Visual obstacles negatively affected driver behavior with worse driving performance. • Pedestrian-vehicle crash risk model revealed factors' main effects on crash risks. Due to the vision obstruction caused by visually blind obstacles on urban roads, pedestrians suffer a high crash risk in pedestrian-vehicle conflicts. At the same time, the connected information can potentially improve driver behaviour with an earlier warning and driving aids. To ensure safer interactions between pedestrians and motor vehicles in the middle section of urban roads, this simulator-based study aims to investigate drivers' behaviour under the influence of connected information and predict crash risk during their interaction with pedestrians on urban roads, involving six conflict scenarios based on real-world traffic situations. The test employed a mixed experimental design, with connected information as the between-subject variable. A total of 70 participants were divided into a control group and an experimental group to complete the test. Results from linear mixed-effects models indicated that the presence of connected information and crosswalks positively influenced driver braking behaviour, resulting in a shorter reaction time, longer braking duration and distance, smaller maximum deceleration, and a reduced standard deviation of deceleration. Conversely, visual obstacles led to longer reaction times, while parked cars and buses negatively affected driver behaviour. Further, aggressive drivers exhibited poorer braking behaviour compared to neutral drivers. An explainable machine learning model was developed to predict pedestrian-vehicle crash risks during interactions, demonstrating satisfactory predictive accuracy. The presence of connected information and crosswalks was found to have a positive effect on reducing crash risks and improving safety margins. These findings provide valuable insights for implementing connected driving technology and developing measures to enhance pedestrian safety. [ABSTRACT FROM AUTHOR]

Introduction The reality of pilot health care avoidance behavior is often common knowledge to both pilots and aeromedical physicians, but the underlying factors leading to this behavior are less understood. In the current study, we conducted a qualitative assessment of a sample of U.S. Air Force (USAF) pilots to gather firsthand perceptions of the factors that encourage and discourage disclosure during aeromedical screening and use of mental and physical health care services, as well as recommendations to improve the USAF aeromedical health care system. Materials and Methods We conducted interviews with 21 USAF pilots on their perceptions of seeking medical care to identify factors that uniquely discourage or encourage disclosure and health care utilization to understand factors that aid the aeromedical provider/aviator relationship and to elicit interventions that could be prospectively researched. This work was reviewed by the Air Force Research Laboratory Institutional Review Board at Wright-Patterson Air Force Base and designated as exempt research, FWR20220103E. Results The most reported factors that discourage military pilot health care disclosure and health care utilization overall were medical revocation, stigma, and lack of trust in providers. Unit-embedded services, ease of access, and severity of condition were the most reported factors encouraging disclosure and utilization. Factor descriptions and exemplary quotes from pilots and pilot recommendations to encourage health care utilization and disclosure are provided. Conclusions Results from firsthand interviews with pilots provide valuable information for flight surgeons to focus on building trust with their pilots to reduce health care avoidance. [ABSTRACT FROM AUTHOR]

Zinc oxide nanoparticles (ZnO-NPs) are commonly used in both commercial and agricultural sectors. As a result, ZnO-NPs are extensively discharged into soil ecosystems, creating a significant environmental issue. Therefore, it is crucial to assess their influence on the soil ecology to ensure its secure and enduring utilization in the future. The exact degree of toxicity associated with ZnO-NPs and their ionic form is still uncertain. To address the challenges, the study used the soil bioindicator earthworm species Eudrilus eugeniae as an experimental model to evaluate the effects of two zinc species (ZnO-NPs and ZnCl2) at 100, 250, 500, and 750 mg kg−1 and control (0 mg kg−1) in garden soil over 28 days. The investigation also examined the impact of exposure on survival, reproduction, neuro-biomarker, avoidance behavior, and accumulation. The highest avoidance rates were 27.5% for ZnO-NP and 37.5% for ZnCl2 at 750 mg kg−1. ZnCl2 treatment reduced juvenile production by 3.73 ± 1.73, while ZnO-NPs showed 4.67 ± 1.15. At 750 mg kg−1, soils with ZnCl2 (63.3%) demonstrated lower survival rates than those with ZnO-NPs (53.3%), likely because of higher Zn ion levels. After 28 days of exposure, ZnCl2 (536.32 ± 11 mol min−1) activated AChE enzymes more than ZnO-NPs (497.7 ± 59 mol min−1) at the same dose, compared to control (145.88 ± 28 to 149.41 ± 23 mol min−1). Nanoparticles and zinc ions bioaccumulated and reacted negatively with the neurotoxic marker AChE, affecting earthworm reproduction and behavior. However, earthworms exposed to ZnCl2 exhibited less intestinal Zn than those exposed to NPs. The present work contradicts the finding that ZnO-NPs have hazardous effects on soil organisms. The results indicate that earthworm E. eugeniae may significantly affect soil metal uptake from metallic nanoparticles (NPs). This may help design NP soil pollution mitigation strategies. The study offers valuable information for establishing a relationship between the environmental toxicity of ZnO-NPs and soil ecosystems. [ABSTRACT FROM AUTHOR]

Background Concerns about falling (CaF) are common in older people and can lead to avoidance of activities, social isolation and reduced physical function. However, there is limited knowledge about CaF in people with osteoarthritis (OA); yet, symptoms may increase CaF. We aimed to evaluate the prevalence of CaF and associated factors in people with knee or hip OA. Methods This cross-sectional study used data from the Good Life with osteoArthritis in Denmark registry including patients with OA treated in primary care. CaF was assessed with the Short Falls Efficacy Scale International (Short FES-I, range 7–28, low to high). Associations between CaF and pain, function and psychological factors were evaluated using multivariable linear Tobit regression. Results In total, 7442 patients were included [mean age 67 years (SD: 9.6), 67% females]. Mean Short FES-I was 9.8 [95% confidence interval (CI): 9.7; 9.8]. Moderate CaF was observed in 48.1% (95% CI: 46.7; 48.9) of participants, whilst 11.3% (95% CI: 10.7; 12.1) had a high level of CaF. CaF was more prevalent in the oldest participants and in females. Pain intensity [β-value (95% CI): 0.52 (0.48; 0.55)], chair stand test [−0.21 (−0.22; −0.19)] and fear of movement [1.38 (1.19; 1.56)] were significantly associated with increased CaF across age groups and sex. Conclusions CaF is common in people with OA, especially in the oldest participants and in females. Higher pain, lower function and psychological distress are associated with CaF; yet, the causality of the associations remain to be determined. Integrating CaF assessments and interventions into OA management in primary care seems highly relevant. [ABSTRACT FROM AUTHOR]

In the case of patients with Chronic Low Back Pain (cLBP), Functional Restoration Programs (FRP) can improve their condition. Chronicity may reoccur and lead to difficulties in the ability to work related to Fear-Avoidance Beliefs, which may depend on lower motor control. Rationale of the study : Whereas a limited clinical scale evaluates these beliefs, our study is justified by the search to define motor control parameters that can be used as quantified indicators of fear-avoidance beliefs associated with work activity. The aim of this study is to explore whether difficulty in working one year after participating in the FRP was related to low motor control in patients with cLBP. Two groups were defined as: "the patients who could work one year after FRP" (called W-Group) and "the patients who could not work one year after FRP because of cLBP" (called NW-Group). The clinical analysis is based on the assessment of pain intensity and the Fear-Avoidance Belief Questionnaire (or FABQ). Gait stability and coefficients of attenuation on four back levels were considered. The NW-Group had a significantly higher FABQ score than the W-Group one year after FRP (p = 0.02) without any difference regarding pain intensity (p = 0.31). The NW-Group (0.11 ± 0.02) presented significantly higher RMS values for the low back in the anteroposterior axis than the W-group (0.09 ± 0.01), showing lower gait stability in the NW-group. Motor control parameters reveal significant differences between these groups. Motor control and fear-avoidance beliefs are associated with work. [ABSTRACT FROM AUTHOR]

This work emphasizes the computational and analytical analysis of integral-differential equations, with a particular application in modeling avoidance learning processes. Firstly, we suggest an approach to determine a unique solution to the given model by employing methods from functional analysis and fixed-point theory. We obtain numerical solutions using the approach of Picard iteration and evaluate their stability in the context of minor perturbations. In addition, we explore the practical application of these techniques by providing two examples that highlight the thorough analysis of behavioral responses using numerical approximations. In the end, we examine the efficacy of our suggested ordinary differential equations (ODEs) for studying the avoidance learning behavior of animals. Furthermore, we investigate the convergence and error analysis of the proposed ODEs using multiple numerical techniques. This integration of theoretical and practical analysis enhances the domain of applied mathematics by providing important insights for behavioral science research. [ABSTRACT FROM AUTHOR]

Stress is an adaptive response crucial for survival. However, chronic stress can lead to maladaptive behaviors and health issues. Prolonged stress reduces the flexibility of defensive coping behaviors. Previous studies have shown that the medial prefrontal cortex (mPFC) and the nucleus accumbens (NAc) play critical roles in maintaining active avoidance instead of freezing behaviors in face of threats. This study aimed to investigate whether chronic stress altered the prelimbic cortex, infralimbic cortex, NAc core and the NAc shell neuronal activation levels and the defensive coping in male rats in face of danger, and we hypothesized that the activation levels of these two brain regions would decrease and the animals would spend more time in freezing. The animals underwent a chronic restraint stress procedure (2 h/day) for consecutive 14 days. Using a cued lever-pressing shock avoidance task, we assessed the avoidance coping and the neuronal activities in the mPFC and the NAc. Our results showed that compared to nonstressed controls, animals that underwent chronic restraint stress were slower in gaining body weight and developed despair-like behaviors in the forced swim test. However, contrary to our hypothesis, chronic restraint stress did not alter active avoidance coping or neuronal activation levels of the mPFC and the NAc.

Under threats, individuals exhibit freezing behavior and prepare for active coping. The ability to flexibly shift between freezing and active coping increases survival chances in animals and decreases susceptibility to mental disorders among human beings. For example, patients with psychiatric disorders, such as obsessive-compulsive disorder and posttraumatic stress disorder, often show maladaptive coping behaviors. The orbitofrontal cortex (OFC) is a critical hub to process higher cognitive functions, sensory inputs, reward learning, and decision-making. It also regulates negative emotions and its aberrant activation level often correlates with numerous mental disorders. The rodent OFC comprises different subdivisions with varying connections to cortical and subcortical regions. Among these subdivisions, the medial orbital area (MO) and the lateral orbital area (LO) have distinct functions in the regulation of fear. Here, we updated the existing rodent literature studying the function of the OFC, with a particular focus on the MO and the LO in different coping strategies of animals. By examining the role of the OFC in the mediation of defensive coping strategies, we aim to deepen the understanding of its functional importance on mental health.

Introduction Despite the high burden of tobacco use in India, users do not have access to adequate help. This pilot trial aimed to evaluate the feasibility and acceptability of a text messaging intervention for tobacco cessation, generate preliminary estimates of its impact, and fine-tune procedures for a definitive trial. Aims and Methods Parallel two-arm single blind individually randomized controlled pilot trial with nested qualitative study. Participants included adult current tobacco users (smoked and smokeless). Eligible and consenting participants were randomized to receive either (1) text messaging intervention (ToQuit) which covered specific content areas such as psychoeducation about consequences of tobacco use and benefits of quitting and tobacco avoidance strategies or (2) information about tobacco cessation helplines such as the helpline number and the languages in which tobacco cessation support was available (control). Feasibility data included screening and consent rates, treatment dropouts, and outcome ascertainment. The primary abstinence outcome was self-reported abstinence from tobacco in the past seven days at 3 months post-randomization. In-depth interviews were conducted with a subsample of participants primarily to collect acceptability data. The primary abstinence analysis used a chi-squared test and logistic regression (complete case), and qualitative data was analyzed using thematic analysis. Results Ninety-eight participants were randomized into the two trial arms; 77 (79%) completed outcome evaluation. No between-arm differences in abstinence were found though findings favored the intervention (7-day abstinence: ToQuit 23%, control 19%; adjusted odds ratio 1.23, 95% confidence interval 0.38, 3.97). Participants appreciated the language, comprehensibility, and relevance of the messages; and reported overall satisfaction with and positive impact from the intervention on their lives. Conclusions The findings indicate the acceptability and feasibility of ToQuit and if found effective, it could be a potentially scalable first-line response to tobacco use in low-resource settings. Implications Our pilot randomized control trial provides sufficient findings supporting the acceptability and feasibility of an intervention for tobacco cessation which is suitable for a context which has a shortage of healthcare workers and for individuals who use smoked or smokeless tobacco. This is critical on a background of limited contextually relevant interventions for a problem with a high burden in low- and middle-income countries such as India. [ABSTRACT FROM AUTHOR]

The current study aimed to create an electrostatic window screen to keep stable flies and houseflies out of cattle barns. The screen comprised three identical framed metal nets arranged in parallel at specific intervals. The central net was connected to a negative-voltage generator to impart a negative charge, while the other two nets were grounded and placed on either side of the charged net. This configuration generated a corona-discharging electric field between the nets. The electric field produced negative ions and ozone around the negatively charged net, deterring houseflies from entering. Additionally, the screen emitted sparks via arc discharge to repel stable flies that did not exhibit avoidance behavior. The spark irradiation was intense enough to swiftly propel flies backward upon entering the electric field, ultimately leading to their demise. In summary, the device functioned as a corona-discharging screen to repel houseflies and as an arc-discharging screen to eliminate stable flies through spark irradiation. This study provides an experimental foundation for the development of an innovative device to manage undesirable flies in cattle barns. [ABSTRACT FROM AUTHOR]

Vehicle collisions with birds are financially costly and dangerous to humans and animals. To reduce collisions, it is necessary to understand how birds respond to approaching vehicles. We used simulated (i.e., animals exposed to video playback) and real vehicle approaches with mallards (Anas platyrynchos) to quantify flight behavior and probability of collision under different vehicle speeds and times of day (day vs. night). Birds exposed to simulated nighttime approaches exhibited reduced probability of attempting escape, but when escape was attempted, fled with more time before collision compared to birds exposed to simulated daytime approaches. The lower probability of flight may indicate that the visual stimulus of vehicle approaches at night (i.e., looming headlights) is perceived as less threatening than when the full vehicle is more visible during the day; alternatively, the mallard visual system might be incompatible with vehicle lighting in dark settings. Mallards approached by a real vehicle exhibited a delayed margin of safety (both flight initiation distance and time before collision decreased with speed); they are the first bird species found to exhibit this response to vehicle approach. Our findings suggest mallards are poorly equipped to adequately respond to fast-moving vehicles and demonstrate the need for continued research into methods promoting effective avian avoidance behaviors. [ABSTRACT FROM AUTHOR]

The advent of artificial lighting, particularly during the evening and night, has significantly altered the predictable daily light and dark cycles in recent times. Altered light environments disrupt the biological clock and negatively impact mood and cognition. Although adolescents commonly experience chronic changes in light/dark cycles, our understanding of how the adolescents’ brain adapts to altered light environments remains limited. Here, we investigated the impact of chronic light cycle disruption (LCD) during adolescence, exposing adolescent mice to 19  h of light and 5  h of darkness for 5  days and 12  L:12D for 2  days per week (LCD group) for 4  weeks. We showed that LCD exposure did not affect circadian locomotor activity but impaired memory and increased avoidance response in adolescent mice. Clock gene expression and neuronal activity rhythms analysis revealed that LCD disrupted local molecular clock and neuronal activity in the dentate gyrus (DG) and in the medial amygdala (MeA) but not in the circadian pacemaker (SCN). In addition, we characterized the photoresponsiveness of the MeA and showed that somatostatin neurons are affected by acute and chronic aberrant light exposure during adolescence. Our research provides new evidence highlighting the potential consequences of altered light environments during pubertal development on neuronal physiology and behaviors. [ABSTRACT FROM AUTHOR]

Background: Illness perceptions (IPs) and avoidance behavior both predict quality of life (QoL) in people with irritable bowel syndrome (IBS). This study examined whether the effects of IPs on QoL are mediated by avoidance behaviors, and whether this mediation is moderated by participant treatment-seeking status.Methods: People with self-reported IBS (n = 253) answered a survey assessing QoL, IPs, avoidance behaviors, and treatment-seeking status. Moderated-mediation analyses investigated the paths from IPs through avoidance behaviors to QoL, with treatment-seeking status entered as a moderator.Results: The final moderated mediation model included the IPs consequences, timeline and emotional representations as independent variables and avoidance behavior and depressive reactions as mediators. This model explained 68.6% of the variance in QoL. Among treatment-seeking participants five significant mediation effects were found, whereas only one significant mediation effect was found among participants who did not report seeking treatment.Conclusions: IPs seem to drive avoidant behavioral responses to IBS symptoms, which in turn predict reductions in QoL. These relationships seem more pronounced among people who seek treatment for their symptoms. In practice, health care practitioners might help improve the QoL of people with IBS by preventing or remedying the development of negative IPs and avoidance behaviors.

Context: To determine (1) whether physical function and fear of movement are prospectively associated with the risk of females developing patellofemoral pain (PFP) and (2) whether they change following development of PFP. Design: Prospective observational study. Methods: A total of 114 asymptomatic females (18–22 y old) completed assessment of physical function (forward step-down test and single-leg hop for distance) and fear of movement using the Tampa Scale for Kinesiophobia at baseline and 2-year follow-up. Presence of symptoms of PFP was monitored bimonthly. Results: Ninety participants (retention rate = 79%) completed the 2-year follow-up assessment, with 27 (24% of the cohort) developing PFP. Physical function, including forward step-down test (P =.659) and single-leg hop for distance (P =.825), and fear of movement (P =.479) were not associated with the risk of developing PFP. Females who developed PFP presented with reduced forward step-down repetitions (mean difference = 2.8; 95% confidence interval, 0.2 to 5.3) and single-leg hop for distance (10.2; 95% confidence interval, 2.7 to 17.7 cm) at 2-year follow-up. There was no statistically significant difference between those who did and did not develop PFP for fear of movement (−3.4; 95% confidence interval, −7.0 to 0.2). Conclusions: Physical function and fear of movement were not associated with the risk of developing PFP in young females. However, the change over time in the step-down and single-leg hop for distance tests may suggest that, even in the early stages of PFP, young females present impaired physical function compared with females who did not develop symptoms. Fear of movement may develop due to persistent PFP, and does not appear to be a risk factor or key feature in females with PFP of short symptoms duration. [ABSTRACT FROM AUTHOR]

Introduction Mild traumatic brain injury (mTBI), depression, and PTSD are highly prevalent in post-9/11 veterans. With the comorbidity of depression and PTSD in post-9/11 veterans with mTBI histories and their role in exacerbating cognitive and emotional dysfunction, interventions addressing cognitive and psychiatric functioning are critical. Compensatory Cognitive Training (CCT) is associated with improvements in prospective memory, attention, and executive functioning and has also yielded small-to-medium treatment effects on PTSD and depressive symptom severity. We sought to examine neuropsychological correlates of PTSD and depressive symptom improvement in veterans with a history of mTBI who received CCT. Materials and Methods Thirty-seven post-9/11 veterans with mTBI histories and cognitive complaints received 10 weekly 120-minute CCT group sessions. Participants completed a baseline neuropsychological assessment, including tests of premorbid functioning, attention/working memory, processing speed, verbal learning/memory, and executive functioning, and completed psychiatric symptom measures (PTSD and depression) at baseline, post-treatment, and a 5-week follow-up. Paired samples t -tests were used to examine statistically significant changes in PTSD (total and symptom cluster scores) and depressive symptom scores over time. Pearson's correlations were calculated between neuropsychological scores and PTSD and depressive symptom change scores at post-treatment and follow-up. Neuropsychological measures identified as significantly correlated with psychiatric symptom change scores were entered as independent variables in multivariable regression analyses to examine their association with symptom change at post-treatment and follow-up. Results Over 50% of CCT participants had clinically meaningful improvement in depressive symptoms (≥17.5% score reduction), and over 20% had clinically meaningful improvement in PTSD symptoms (≥10-point improvement) at post-treatment and follow-up. Examination of PTSD symptom cluster scores revealed a statistically significant improvement in avoidance/numbing at follow-up. Bivariate correlations indicated that worse baseline performance on Category Fluency was moderately associated with PTSD symptom improvement at post-treatment. Worse performance on both Category Fluency and Category Switching Accuracy was associated with improvement in depressive symptoms at post-treatment and follow-up. Worse performance on Trail-Making Number-Letter Switching was also associated with improvement in depressive symptoms at follow-up. Subsequent regression analyses revealed that worse processing speed and worse aspects of executive functioning at baseline were associated with depressive symptom improvement at post-treatment and follow-up. Conclusions Worse baseline performances on tests of processing speed and aspects of executive functioning were significantly associated with improvements in PTSD and depressive symptoms during the trial. Our results suggest that cognitive training may bolster skills that are helpful for PTSD and depressive symptom reduction and that those with worse baseline functioning may benefit more from treatment because they have more room to improve. [ABSTRACT FROM AUTHOR]

Anthropogenic noise is one of the fastest growing, globally widespread pollutants, affecting countless species worldwide. Despite accumulating evidence of the negative impacts of wind turbines on wildlife, little is known about how the noise they generate affects ecological systems. Songbirds may be susceptible to noise pollution due to their reliance on vocal communication and thus, in this field study, we examined how songbirds are affected by wind turbine noise. We broadcasted noise produced by one wind turbine in a migratory stopover site during the nonbreeding season. Throughout the study, we repeatedly monitored the acoustic environment and songbird community before, during, and after the noise treatments with passive acoustic monitoring and mist netting. We employed generalized linear mixed effects models to assess the impact of experimental noise treatment on birds behavior and likelihood ratio tests to compare models with variables of interest with null models. The daily number of birds in the presence of wind turbine noise decreased by approximately 30% compared with the before and after phases. This reduction had a significant spatial pattern; the largest decrease was closer to the speaker and on its downwind side, fitting measured sound propagation. Although we found no impact on species diversity, two out of three most common species showed clear avoidance behavior: 45% and 36% decrease in abundance for the lesser whitethroat (Sylvia curruca) and Sardinian warbler (Sylvia melanocephala momus), respectively. In the after phase, there were lingering effects on the lesser whitethroat. The age structure of the lesser whitethroat population was affected because only juvenile birds showed avoidance behavior. No difference in avoidance extent was found between migratory and nonmigratory species, but the impacts of displacement on migrants during stopover are especially troubling from a conservation perspective. Our results stress the need to address the impacts of noise pollution on wildlife when planning noise‐generating infrastructures, such as wind turbines, to allow for sustainable development without threatening already declining songbird populations. [ABSTRACT FROM AUTHOR]

Vehicle collisions with birds are financially costly and dangerous to humans and animals. To reduce collisions, it is necessary to understand how birds respond to approaching vehicles. We used simulated (i.e., animals exposed to video playback) and real vehicle approaches with mallards (Anas platyrynchos) to quantify flight behavior and probability of collision under different vehicle speeds and times of day (day vs. night). Birds exposed to simulated nighttime approaches exhibited reduced probability of attempting escape, but when escape was attempted, fled with more time before collision compared to birds exposed to simulated daytime approaches. The lower probability of flight may indicate that the visual stimulus of vehicle approaches at night (i.e., looming headlights) is perceived as less threatening than when the full vehicle is more visible during the day; alternatively, the mallard visual system might be incompatible with vehicle lighting in dark settings. Mallards approached by a real vehicle exhibited a delayed margin of safety (both flight initiation distance and time before collision decreased with speed); they are the first bird species found to exhibit this response to vehicle approach. Our findings suggest mallards are poorly equipped to adequately respond to fast-moving vehicles and demonstrate the need for continued research into methods promoting effective avian avoidance behaviors.

Abstract Background Schizophrenia often involves persecutory delusions, which cause psychological distress. Some patients use online gaming as a coping tool. However, excessive online gaming has raised concerns about internet gaming disorders (IGD), while any soothing effects of online gaming on psychological distress remain unclear. Herein, we report changes in anxiety and IGD severity, measured using rating scales, in a patient with schizophrenia who used online gaming as a coping strategy for psychological distress. Case Presentation A 43‐year‐old woman diagnosed with schizophrenia had worsening persecutory delusions, including that of being targeted by snipers, and had difficulty going out because of anxiety. She coped with her psychological distress using online shooting games. We assessed her state and trait anxiety, social anxiety, avoidance behavior when alone, and IGD severity. There was a notable reduction in the state anxiety score after the introduction of online gaming. The scores for trait anxiety, social anxiety, and avoidance behavior when alone decreased noticeably after the acquisition of coping strategies. This case demonstrates the presence of IGD only during the acquisition of coping strategies. Conclusion This case highlights the potential of online gaming as a coping strategy for schizophrenia‐related anxiety. However, excessive gaming can lead to IGD and thus necessitates caution. Further research should explore the applicability and potential risks of using online gaming to cope with psychological distress among patients with schizophrenia.

Abstract Background Ecosystems are brimming with myriad compounds, including some at very low concentrations that are indispensable for insect survival and reproduction. Screening strategies for identifying active compounds are typically based on bioassay-guided approaches. Results Here, we selected two candidate odorant receptors from a major pest of cruciferous plants—the diamondback moth Plutella xylostella—as targets to screen for active semiochemicals. One of these ORs, PxylOR16, exhibited a specific, sensitive response to heptanal, with both larvae and adult P. xylostella displaying heptanal avoidance behavior. Gene knockout studies based on CRISPR/Cas9 experimentally confirmed that PxylOR16 mediates this avoidance. Intriguingly, rather than being involved in P. xylostella–host plant interaction, we discovered that P. xylostella recognizes heptanal from the cuticular volatiles of the parasitoid wasp Cotesia vestalis, possibly to avoid parasitization. Conclusions Our study thus showcases how the deorphanization of odorant receptors can drive discoveries about their complex functions in mediating insect survival. We also demonstrate that the use of odorant receptors as a screening platform could be efficient in identifying new behavioral regulators for application in pest management.

Freshwater fishes exhibit a wide range of auditory adaptations and capabilities, which are assumed to help them navigate their environment, avoid predators, and find potential mates. Yet, we know very little about how freshwater environments sound to fish, or how fish with different auditory adaptations respond to different soundscapes. We first compiled data on fish hearing acuity and adaptations and provided a portrait of how anthropogenic sounds compare to natural sounds in different freshwater soundscapes. We then conducted a sound‐enrichment field experiment at Lake Saint Pierre, a large fluvial lake in Canada, to evaluate the effect of motorboat sound exposure on the fish community by looking at the extent to which changes in species abundances were linked to auditory adaptations. Data compilation showed that the hearing acuity of most species overlaps with a wide range of ambient and anthropogenic underwater sounds while the field experiment showed that species with more specialized auditory structures were captured less often in sound‐enriched traps, indicating avoidance behavior. Our findings highlight the importance of considering species' sensorial adaptations when evaluating the community‐scale effects of anthropogenic sounds on the fish community, especially at low levels of anthropogenic activity. [ABSTRACT FROM AUTHOR]

We outline how a predictive processing framework based on active inference can help overcome the limitations of fragmented feed-forward processing theories and more comprehensively explain the role of the amygdala in anxiety, fear, and danger detection. This framework integrates theoretical predictions with empirical findings, suggesting that the central amygdala subnucleus acts as a Bayesian regulator of an interoceptive self-model, sending top-down predictions to the basolateral amygdala for efficient perception. Fear conditioning is discussed as an example of proactive homeostatic regulation, where exteroceptive cues are used to anticipate negative interoceptive experiences. By extension, other amygdala functions (e.g., its role in approach/avoidance behavior or attention) can be explained using the same computational principles within a hierarchical active inference model. The amygdala is a heterogeneous network of subcortical nuclei with central importance in cognitive and clinical neuroscience. Various experimental designs in human psychology and animal model research have mapped multiple conceptual frameworks (e.g., valence/salience and decision making) to ever more refined amygdala circuitry. However, these predominantly bottom up-driven accounts often rely on interpretations tailored to a specific phenomenon, thus preventing comprehensive and integrative theories. We argue here that an active inference model of amygdala function could unify these fractionated approaches into an overarching framework for clearer empirical predictions and mechanistic interpretations. This framework embeds top-down predictive models, informed by prior knowledge and belief updating, within a dynamical system distributed across amygdala circuits in which self-regulation is implemented by continuously tracking environmental and homeostatic demands. [ABSTRACT FROM AUTHOR]

Purpose: The study aims to examine fast fashion consumers' negative in-store experiences focusing on the effect of the two store environment factors, product overload and store ambiance, on their confusion and consequent shopping avoidance behavior. Design/methodology/approach: A research model of fast fashion consumers' confusion and store avoidance behavior is proposed using the Stimulus–Organism–Response framework. A pretest and the main online survey with 281 samples are analyzed, and the structural equation modeling (SEM) is conducted to test the proposed model. Findings: The SEM results support the proposed paths statistically. Consumers' confusion, measured with the two dimensions, inefficiency and helplessness, is significantly influenced by their perceived product overload and negative perception of store ambiance in the fast fashion shopping environment. Subsequently, fast fashion consumers' confusion results in less time spent in the store. Originality/value: The study sheds light on utilitarian shopping value in the fast fashion shopping environment by focusing on the fast fashion consumers' confusion in association with overloaded information caused by too many products and store ambiance. Research limitations/implications: The study implies that improving fast fashion stores' inherent issues with too many products and store ambiance might help consumers mitigate their confusion and prevent customer attrition. However, the study includes only two factors. Future studies may include other various fast fashion store factors. Additionally, one of the dimensions of confusion, irritation, did not emerge in this study. More work is needed to investigate fast fashion consumers' confusion, such as using a multigroup analysis by age. [ABSTRACT FROM AUTHOR]

The current study aimed to create an electrostatic window screen to keep stable flies and houseflies out of cattle barns. The screen comprised three identical framed metal nets arranged in parallel at specific intervals. The central net was connected to a negative-voltage generator to impart a negative charge, while the other two nets were grounded and placed on either side of the charged net. This configuration generated a corona-discharging electric field between the nets. The electric field produced negative ions and ozone around the negatively charged net, deterring houseflies from entering. Additionally, the screen emitted sparks via arc discharge to repel stable flies that did not exhibit avoidance behavior. The spark irradiation was intense enough to swiftly propel flies backward upon entering the electric field, ultimately leading to their demise. In summary, the device functioned as a corona-discharging screen to repel houseflies and as an arc-discharging screen to eliminate stable flies through spark irradiation. This study provides an experimental foundation for the development of an innovative device to manage undesirable flies in cattle barns.

Abstract Freshwater fishes exhibit a wide range of auditory adaptations and capabilities, which are assumed to help them navigate their environment, avoid predators, and find potential mates. Yet, we know very little about how freshwater environments sound to fish, or how fish with different auditory adaptations respond to different soundscapes. We first compiled data on fish hearing acuity and adaptations and provided a portrait of how anthropogenic sounds compare to natural sounds in different freshwater soundscapes. We then conducted a sound‐enrichment field experiment at Lake Saint Pierre, a large fluvial lake in Canada, to evaluate the effect of motorboat sound exposure on the fish community by looking at the extent to which changes in species abundances were linked to auditory adaptations. Data compilation showed that the hearing acuity of most species overlaps with a wide range of ambient and anthropogenic underwater sounds while the field experiment showed that species with more specialized auditory structures were captured less often in sound‐enriched traps, indicating avoidance behavior. Our findings highlight the importance of considering species' sensorial adaptations when evaluating the community‐scale effects of anthropogenic sounds on the fish community, especially at low levels of anthropogenic activity.

The survival of hosts during infections relies on their ability to mount effective molecular and behavioral immune responses. Despite extensive research on these defense strategies in various species, including the model organism Caenorhabditis elegans, the neural mechanisms underlying their interaction remain poorly understood. Previous studies have highlighted the role of neural G-protein-coupled receptors (GPCRs) in regulating both immunity and pathogen avoidance, which is particularly dependent on aerotaxis. To address this knowledge gap, we conducted a screen of mutants in neuropeptide receptor family genes. We found that loss-of-function mutations in npr-15 activated immunity while suppressing pathogen avoidance behavior. Through further analysis, NPR-15 was found to regulate immunity by modulating the activity of key transcription factors, namely GATA/ELT-2 and TFEB/HLH-30. Surprisingly, the lack of pathogen avoidance of npr-15 mutant animals was not influenced by oxygen levels. Moreover, our studies revealed that the amphid sensory neuron ASJ is involved in mediating the immune and behavioral responses orchestrated by NPR-15. Additionally, NPR-15 was found to regulate avoidance behavior via the TRPM (transient receptor potential melastatin) gene, GON-2, which may sense the intestinal distension caused by bacterial colonization to elicit pathogen avoidance. Our study contributes to a broader understanding of host defense strategies and mechanisms underlining the interaction between molecular and behavioral immune responses.

Collisions between birds and aircraft cause bird mortality, economic damage, and aviation safety hazards. One proposed solution to increasing the distance at which birds detect and move away from an approaching aircraft, ultimately mitigating the probability of collision, is through onboard lighting systems. Lights in vehicles have been shown to lead to earlier reactions in some bird species but they could also generate attraction, potentially increasing the probability of collision. Using information on the visual system of the Canada goose (Branta canadensis), we developed light stimuli of high chromatic contrast to their eyes. We then conducted a controlled behavioral experiment (i.e., single-choice test) to assess the avoidance or attraction responses of Canada geese to LED lights of different wavelengths (blue, 483 nm; red, 631 nm) and pulsing frequencies (steady, pulsing at 2 Hz). Overall, Canada geese tended to avoid the blue light and move towards the red light; however, these responses depended heavily on light exposure order. At the beginning of the experiment, geese tended to avoid the red light. After further exposure the birds developed an attraction to the red light, consistent with the mere exposure effect. The response to the blue light generally followed a U-shape relationship (avoidance, attraction, avoidance) with increasing number of exposures, again consistent with the mere exposure effect, but followed by the satiation effect. Lights pulsing at 2 Hz enhanced avoidance responses under high ambient light conditions; whereas steady lights enhanced avoidance responses under dim ambient light conditions. Our results have implications for the design of lighting systems aimed at mitigating collisions between birds and human objects. LED lights in the blue portion of the spectrum are good candidates for deterrents and lights in the red portion of the spectrum may be counterproductive given the attraction effects with increasing exposure. Additionally, consideration should be given to systems that automatically modify pulsing of the light depending on ambient light intensity to enhance avoidance. [ABSTRACT FROM AUTHOR]

This study explored how the allocation of human assistants in a technology-mediated service setting could reduce the exclusion of senior citizens from such services. Our methodology is based on social support and protection motivation theories. Using a two-phase study with a mixed-methods approach, we firstly conducted 25 semistructured interviews to develop the research model. The model was then empirically validated using survey data from 285 Chinese senior citizens. The results revealed that senior citizens experienced defense motivation and avoidance behavior when facing technology-mediated services. However, perceived emotional support from a human assistant enhanced their evaluation of coping factors, further reducing their defense motivations and avoidance behaviors. Perceived instrumental support had a greater impact, as it both reduced their assessment of threat factors and enhanced their evaluation of coping factors. Finally, future time perspective moderated the effects of perceived support on threat and coping appraisal processing. [ABSTRACT FROM AUTHOR]

The article discusses how anxious avoidance in individuals with cardiovascular disease affects their physical activity and cardiovascular outcomes, emphasizing the need for interventions targeting both anxiety and behavior. Topics include the role of anxiety in cardiovascular health, the potential of integrated interventions addressing anxiety and physical activity, and the challenges of low adherence to behavioral interventions for heart disease patients.

Collisions between birds and aircraft cause bird mortality, economic damage, and aviation safety hazards. One proposed solution to increasing the distance at which birds detect and move away from an approaching aircraft, ultimately mitigating the probability of collision, is through onboard lighting systems. Lights in vehicles have been shown to lead to earlier reactions in some bird species but they could also generate attraction, potentially increasing the probability of collision. Using information on the visual system of the Canada goose (Branta canadensis), we developed light stimuli of high chromatic contrast to their eyes. We then conducted a controlled behavioral experiment (i.e., single-choice test) to assess the avoidance or attraction responses of Canada geese to LED lights of different wavelengths (blue, 483 nm; red, 631 nm) and pulsing frequencies (steady, pulsing at 2 Hz). Overall, Canada geese tended to avoid the blue light and move towards the red light; however, these responses depended heavily on light exposure order. At the beginning of the experiment, geese tended to avoid the red light. After further exposure the birds developed an attraction to the red light, consistent with the mere exposure effect. The response to the blue light generally followed a U-shape relationship (avoidance, attraction, avoidance) with increasing number of exposures, again consistent with the mere exposure effect, but followed by the satiation effect. Lights pulsing at 2 Hz enhanced avoidance responses under high ambient light conditions; whereas steady lights enhanced avoidance responses under dim ambient light conditions. Our results have implications for the design of lighting systems aimed at mitigating collisions between birds and human objects. LED lights in the blue portion of the spectrum are good candidates for deterrents and lights in the red portion of the spectrum may be counterproductive given the attraction effects with increasing exposure. Additionally, consideration should be given to systems that automatically modify pulsing of the light depending on ambient light intensity to enhance avoidance.

Simple Summary: The deployment of synergistic insecticide combinations is intended to reduce both the dose of the substances used and the danger of insect populations developing physiological resistance to these insecticides. In order to test this hypothesis, two compounds (β-caryophyllene oxide and vetiver oil), with proven mosquito-repellent properties, were combined to enhance repellent efficacy. In general, the mixture of the compounds had a much stronger effect on mosquitoes than the individual compounds. The combination of β-caryophyllene oxide and vetiver oil produced additive contact irritability as a noncontact repellent, showing knockdown activities at low concentrations, indicating that combinations of these two repellent compounds can be used to develop a mosquito repellent that is more effective than a single compound. From a practical standpoint, both compounds must be formulated as herbal products and must undergo preliminary laboratory testing. Repellents play a major role in reducing the risk of mosquito-borne diseases by preventing mosquito bites. The present study evaluated the mosquito-repellent activity of β-caryophyllene oxide 1% (BCO), vetiver oil 2.5% (VO), and their binary mixtures (BCO + VO (1:1), BCO + VO (2:1), BCO + VO (1:2)) against four laboratory-colonized mosquito species, Aedes aegypti (L.), Aedes albopictus (Skuse), Anopheles minimus Theobald, and Culex quinquefasciatus Say, using an excito-repellency assay system. In general, the compound mixtures produced a much stronger response in the mosquitoes than single compounds, regardless of the test conditions or species. The greatest synergetic effect was achieved with the combination of BCO + VO (1:2) in both contact and noncontact trials with An. minimus (74.07–78.18%) and Cx. quinquefasciatus (55.36–83.64%). Knockdown responses to the binary mixture of BCO + VO were observed for Ae. albopictus, An. minimus, and Cx. quinquefasciatus, in the range of 18.18–33.33%. The synergistic repellent activity of BCO and VO used in this study may support increased opportunities to develop safer alternatives to synthetic repellents for personal protection against mosquitoes. [ABSTRACT FROM AUTHOR]

Predators can induce behavioral changes in prey that influence vigilance, grouping patterns, and space use, and these can ultimately affect prey demography and trophic interactions. Consequently, prey must respond to the risk of predation, but little is known about the features that drive the spatial responses of prey species to predators. We tested what factors affected the proximity of prey to the lions reintroduced to Addo Elephant National Park, South Africa. We also tested whether prey species that are preferentially killed by lions revealed greater responsiveness than those that are not, and whether prey respond to predator behavioral states and hunger. From 1588 observations of potential prey locations in relation to lions under varying wind directions, lion behaviors, and hunger states throughout the day and night, we found no evidence of wind‐driven odor responses affecting prey proximity to lions. Prey species that were not preferentially preyed upon by lions occurred closer to lions than those species that lions prefer to hunt. Prey were closer to lions performing noisy behaviors compared to those performing quiet behaviors. Prey were more likely to be closer to covertly behaving lions and further from stationary lions. Our results, compared to the published literature and accepted dogma of the primacy of odor in predator detection, suggest large vertebrate prey responses to predators in intact, multi‐species assemblages are context dependent. [ABSTRACT FROM AUTHOR]

Our understanding of the evolutionary significance of ectoparasites in natural communities is limited by a paucity of information concerning the mechanisms and heritability of resistance to this ubiquitous group of organisms. Here, we report the results of artificial selection for increasing ectoparasite resistance in replicate lines of Drosophila melanogaster derived from a field-fresh population. Resistance, as ability to avoid infestation by naturally co-occurring Gamasodes queenslandicus mites, increased significantly in response to selection and realized heritability (SE) was estimated to be 0.11 (0.0090). Deployment of energetically expensive bursts of flight from the substrate was a main mechanism of host resistance that responded to selection, aligning with previously documented metabolic costs of fly behavioral defenses. Host body size, which affects parasitism rate in some fly–mite systems, was not shifted by selection. In contrast, resistant lines expressed significant reductions in larva-to-adult survivorship with increasing toxic (ammonia) stress, identifying an environmentally modulated preadult cost of resistance. Flies selected for resistance to G. queenslandicus were also more resistant to a different mite, Macrocheles subbadius , suggesting that we documented genetic variation and a pleiotropic cost of broad-spectrum behavioral immunity against ectoparasites. The results demonstrate significant evolutionary potential of resistance to an ecologically important class of parasites. [ABSTRACT FROM AUTHOR]

* OBJECTIVE: The validity of existing fear avoidance behavior patient-reported outcome measures (PROMs) for concussion is unknown. This study aims to (1) identify PROMs that assess fear avoidance behavior in individuals with concussion and (2) assess the measurement properties of these PROMs. * DESIGN: A systematic review of outcome measurement instruments using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) checklist. * LITERATURE SEARCH: We performed a systematic search of 7 databases. * STUDY SELECTION CRITERIA: Studies were included if they assessed fear avoidance behavior (eg, kinesiophobia or cogniphobia) in participants with concussion, occurring in all settings (eg, sport, falls, assaults). t DATA SYNTHESIS: Methodological quality of the PROMs was assessed using the COSMIN checklist, and the certainty of the evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. * RESULTS: We identified 40 studies assessing fear avoidance. Four studies (n = 875 participants, representing 3 PROMs) were eligible for COSMIN assessment. Content validity for all PROMs was insufficient due to extreme risk of bias. The Fear Avoidance Short Form Scale demonstrated the greatest validity: moderate-certainty evidence for sufficient structural validity and internal consistency, and low-certainty evidence for measurement invariance. * CONCLUSION: Current PROMs for measuring fear avoidance behaviors in people with concussion have insufficient content validity and should be used with caution in research and clinical practice. [ABSTRACT FROM AUTHOR]

Transgender (trans) and gender-diverse (GD) adolescents and young adults have remained largely invisible in health research. Previous research shows worse outcomes in health indicators for trans and GD people, compared to cisgender controls. Research on the impact of sexual violence focuses on mainly cisgender female adult victims. This study assessed the impact of sexual violence on the quality of life (QoL) and mental wellbeing (GHQ-12) among trans and GD adolescents and young adults, while taking into account the possible role of gender nonconformity in sexual violence and mental wellbeing. An online, anonymous survey and interviews/focus groups were conducted between October 2021 and May 2022 in Belgium. Multiple analyses of covariance (ANCOVAs) were used to assess the associations between sexual violence, mental wellbeing, and gender nonconformity, while controlling for different background variables (gender identity, sexual orientation, age, economic vulnerability, etc.). The interviews and focus groups were used to validate associations between variables that were hypothesized as important. The quantitative sample consisted of 110 respondents between 15 and 25 years old, with 30 trans respondents (27.3%) and 80 GD respondents (72.7%). A total of 73.6% reported experiences with sexual violence over the past two years (n = 81). The mean QoL score was 5.3/10, and the mean GHQ-12 score was 6.6/12. Sexual violence was not significantly associated with QoL (p = 0.157) and only marginally significantly associated with GHQ-12 (p = 0.05). Changing one's physical appearance to conform to gender norms, out of fear of getting attacked, discriminated against, or harassed was significantly associated with QoL (p = 0.009) and GHQ-12 (p = 0.041). The association between sexual violence and changing one's physical appearance to conform to gender norms was analyzed, to assess a possible mediation effect of sexual violence on mental wellbeing. No significant association was found (p = 0.261). However, the interviews suggest that sexual violence is associated with changing one's physical appearance, but this association is not limited to only trans and GD victims of sexual violence. Non-victims also adjust their appearance, out of fear of future sexual victimization. Together with the high proportion of sexual violence, as well as the lower average QoL and higher average GHQ-12 scores among trans and GD adolescents and young adults, compared to general population statistics, this highlights the need for policy makers to create more inclusive environments. [ABSTRACT FROM AUTHOR]

Objective: The aim of this study was to investigate the preliminary validity of two novel scales, the Fear of Asthma Symptoms scale (FAS) and the Asthma Behavior Checklist (ABC). Methods: Using cross-sectional design, data was collected online from 188 adult participants (Age 18-71 years) with a diagnosis of asthma and self-reported anxiety related to asthma, recruited through social media. Confirmatory factor analysis, internal consistency and test-retest reliability were ascertained to address validity.Results: The confirmatory factor analysis demonstrated convergent validity for both the FAS (average variance extracted; AVE=.57) and the item-reduced ABC-8 (AVE=.61) as well as divergent validity for both scales. Both scales demonstrated high internal consistency (FAS: α = 0.94; ABC-8: α = 0.92). Test-retest reliability assessed after 1 week was good (FAS: r=.85; ABC-8: r=.88).Conclusions: We observed promising psychometric properties of the FAS and the ABC-8. The two novel scales could be useful to identify excessive fear and avoidance in patients with asthma and to investigate putative mechanisms in clinical research on anxiety related to asthma. Further evaluation of psychometric properties in independent samples are needed. [ABSTRACT FROM AUTHOR]

Rationale: Balancing approach of positive and avoidance of negative stimuli is essential when faced with approach-avoidance conflicts, e.g., situations with both positive and negative outcomes. This balance is disturbed in several mental disorders, e.g., excessive avoidance in anxiety disorders, and heightened approach in substance use disorders. Since stress is assumed to impact these disorders' etiology and maintenance, it seems crucial to understand how stress influences behavior in approach-avoidance conflicts. Indeed, some studies suggested altered approach-avoidance behavior under acute stress, but the mechanism underlying these effects is unknown. Objectives: Investigate how the pharmacological manipulation of major stress mediators (cortisol and noradrenaline) influences task-based approach-avoidance conflict behavior in healthy individuals. Methods: Ninety-six participants (48 women, 48 men) received either 20mg hydrocortisone, 20mg yohimbine, both, or placebo before performing a task targeting foraging under predation in a fully crossed double-blind between-subject design. Moreover, we investigated effects of gender and endogenous testosterone and estradiol levels on approach-avoidance behavior. Results: While biological stress markers (cortisol concentration, alpha amylase activity) indicated successful pharmacological manipulation, behavior in approach-avoidance conflicts was not affected as expected. Although yohimbine administration affected risky foraging latency under predation, we found no main effect of hydrocortisone or their interaction on behavior. In contrast, we found gender differences for almost all behavioral outcome measures, which might be explained by differences in endogenous testosterone levels. Conclusions: The investigated major stress mediators were not sufficient to imitate previously shown stress effects on approach-avoidance conflict behavior. We discuss potential reasons for our findings and implications for future research. [ABSTRACT FROM AUTHOR]

Background: Rodents utilize chemical cues to recognize and avoid other conspecifics infected with pathogens. Infection with pathogens and acute inflammation alter the repertoire and signature of olfactory stimuli emitted by a sick individual. These cues are recognized by healthy conspecifics via the vomeronasal or accessory olfactory system, triggering an innate form of avoidance behavior. However, the molecular identity of the sensory neurons and the higher neural circuits involved in the detection of sick conspecifics remain poorly understood. Results: We employed mice that are in an acute state of inflammation induced by systemic administration of lipopolysaccharide (LPS). Through conditional knockout of the G-protein Gαi2 and deletion of other key sensory transduction molecules (Trpc2 and a cluster of 16 vomeronasal type 1 receptors), in combination with behavioral testing, subcellular Ca2+ imaging, and pS6 and c-Fos neuronal activity mapping in freely behaving mice, we show that the Gαi2+ vomeronasal subsystem is required for the detection and avoidance of LPS-treated mice. The active components underlying this avoidance are contained in urine whereas feces extract and two selected bile acids, although detected in a Gαi2-dependent manner, failed to evoke avoidance behavior. Our analyses of dendritic Ca2+ responses in vomeronasal sensory neurons provide insight into the discrimination capabilities of these neurons for urine fractions from LPS-treated mice, and how this discrimination depends on Gαi2. We observed Gαi2-dependent stimulation of multiple brain areas including medial amygdala, ventromedial hypothalamus, and periaqueductal grey. We also identified the lateral habenula, a brain region implicated in negative reward prediction in aversive learning, as a previously unknown target involved in these tasks. Conclusions: Our physiological and behavioral analyses indicate that the sensing and avoidance of LPS-treated sick conspecifics depend on the Gαi2 vomeronasal subsystem. Our observations point to a central role of brain circuits downstream of the olfactory periphery and in the lateral habenula in the detection and avoidance of sick conspecifics, providing new insights into the neural substrates and circuit logic of the sensing of inflammation in mice. [ABSTRACT FROM AUTHOR]

Of the seven working modules of the mentalizing behavioral therapy MVT, the last two modules – module six and seven – are development modules. Previously, access to emotional experience was established with the Emotion Tracking module. Module six, »Affect regulation and self-efficacy«, deals with the development from the affect level to the thinking level, after the physical level has been promoted beforehand. Development is conceived as a dynamic process in relation to specific relationship contexts and situational contexts. A detailed development diagnosis is followed by the treatment of impulse blockades and avoidance behavior. Impulsive action is automated through targeted exercises. This includes correcting the deficits of the affect stage and creating an incentive for the achievements of the next thought stage. In principle, strengths are first built up and deficits reduced, only then does the step to the next higher level follow. This is done with the help of specific diagnostic and working methods. The necessary ability to control is promoted through targeted practice of understanding cause and effect until a theory of the mental or a theory of mind (ToM) is established. Experience-oriented and pictorial-scenic experiences are used for this with the help of physical sensations in order to allow new behavior, to be able to allow vital feelings again and to be able to defend one’s own needs. From here, the step to the seventh module »Change of perspective and empathy« can be made. [ABSTRACT FROM AUTHOR]