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2. [Quality of life, depression and cognitive functions 1. Operational protocol and its implementation]

Author

Rete Infermieri GISSI HF, Di Giulio P, Pera C, Scarano M, Ferri B, Lepore V, Miani D, Tognoni G, Rosson V, Serafini C, Zumino T, Partemi L, Falleroni ML, Moretti L, Porta L, Santorsola A, Tenerelli T, Bertoncelli B, Mengoli G, Stagnitto M, Puddu GM, Masini E, Pasini A, Boni S, Valsesia E, Cornacini G, Melis D, Mulina A, Giurlanda A, Fava M, Bellini P, Vallucci S, Cuomo A, Campanale S, Monatti G, Bianco T, Milli V, Antonelli L, Fanin L, Faiola L, Stefanizzi R, Mariani M, Rossi A, Regnani T, Loreni F, Cianfrocca R, Pisani A, Faraolfi V, Ponzalli P, Savli T, Cresci M, Guardalben S, Belluzzo B, Ruberti R, Zizzi M, Tonda C, Cadrobbi MG, Gilardi R, Mondì A, Costa A, Milan S, Zottarelli A, Parodi B, Sartorio N, Rossin B, Santi A, Cagnan P, Maradei E, Cauteruccio A, Carpino C, Addeo R, Izzo A, Amendola G, Prizzitano AM, Piluso GM, Iadevaio AL, Cinà MT, Cirrincione V, Gumina S, Codato G, Raimondo F, Capiello MG, Creta F, Barbieri M, Chiarella L, Abbondio L, Piccin M, Spillone V, Cutrupi G, Ruggeri A, Sicilia G, Provengano A, Marcari P, Ricci S, Pazzagli E, La Grotteria M, Orsini R, Leandri L, Vetere NA, Braggion E, Giordanino S, Armando S, Zampieri E, Danese MC, Valentini A, Ferrante MG, Santacroce C, Crocetti I, Macchi F, Bernacchi M, Pini D, Varì M, Lucente M, Scaramastra F, Reichardt S, Gabasio S, Zocchi C, Studhika M, Budzowska E, Cescon M, Lazzari D, Prizzon A, Di Biaggio P, Buda C, Mastrangelo V, Avigliano M, Dell'Aquila L, Bonanomi E, Mezzani A, Porcini F, Girardi G., PERRONE FILARDI, PASQUALE, Rete Infermieri GISSI, Hf, Di Giulio, P, Pera, C, Scarano, M, Ferri, B, Lepore, V, Miani, D, Tognoni, G, Rosson, V, Serafini, C, Zumino, T, Partemi, L, Falleroni, Ml, Moretti, L, Porta, L, Santorsola, A, Tenerelli, T, Bertoncelli, B, Mengoli, G, Stagnitto, M, Puddu, Gm, Masini, E, Pasini, A, Boni, S, Valsesia, E, Cornacini, G, Melis, D, Mulina, A, Giurlanda, A, Fava, M, Bellini, P, Vallucci, S, Cuomo, A, Campanale, S, Monatti, G, Bianco, T, Milli, V, Antonelli, L, Fanin, L, Faiola, L, Stefanizzi, R, Mariani, M, Rossi, A, Regnani, T, Loreni, F, Cianfrocca, R, Pisani, A, Faraolfi, V, Ponzalli, P, Savli, T, Cresci, M, Guardalben, S, Belluzzo, B, Ruberti, R, Zizzi, M, Tonda, C, Cadrobbi, Mg, Gilardi, R, Mondì, A, Costa, A, Milan, S, Zottarelli, A, Parodi, B, Sartorio, N, Rossin, B, Santi, A, Cagnan, P, Maradei, E, Cauteruccio, A, Carpino, C, Addeo, R, Izzo, A, Amendola, G, PERRONE FILARDI, Pasquale, Prizzitano, Am, Piluso, Gm, Iadevaio, Al, Cinà, Mt, Cirrincione, V, Gumina, S, Codato, G, Raimondo, F, Capiello, Mg, Creta, F, Barbieri, M, Chiarella, L, Abbondio, L, Piccin, M, Spillone, V, Cutrupi, G, Ruggeri, A, Sicilia, G, Provengano, A, Marcari, P, Ricci, S, Pazzagli, E, La Grotteria, M, Orsini, R, Leandri, L, Vetere, Na, Braggion, E, Giordanino, S, Armando, S, Zampieri, E, Danese, Mc, Valentini, A, Ferrante, Mg, Santacroce, C, Crocetti, I, Macchi, F, Bernacchi, M, Pini, D, Varì, M, Lucente, M, Scaramastra, F, Reichardt, S, Gabasio, S, Zocchi, C, Studhika, M, Budzowska, E, Cescon, M, Lazzari, D, Prizzon, A, Di Biaggio, P, Buda, C, Mastrangelo, V, Avigliano, M, Dell'Aquila, L, Bonanomi, E, Mezzani, A, Porcini, F, and Girardi, G.

Subjects
Time Factors, Depression, Cardiology, Prognosis, Nursing Research, Cognition, Clinical Protocols, Italy, Data Interpretation, Statistical, Surveys and Questionnaires, Quality of Life, Humans, Cardiomyopathies, Geriatric Assessment, Aged, Randomized Controlled Trials as Topic
Abstract

The QDF (Quality of life, Depression and cognitive Function) is a project elaborated and implemented by a Research Network of the nursing personnel of the cardiological services which promoted and run the GISSI-HF trial. It is a "companion study" which included up to 1/3 of all the GISSI-HF centres.To describe the distribution and evaluation of QDF variables measured with standardised instruments (Kansas City Cardiomiopathy Quality of Life questionnaire, KCCQ; Geriaric Depression scale GDS, Mini Mental State Examination MMSE), to verify whether and how far their knowledge could influence clinical decisions; to assess the prognostic impact of QDF values measured at entrance on mortality and morbidity. The study protocol included also a comprehensive evaluation of QDF variables independent from the questionnaires, by the nurses in charge of the study patients (the results of this part of the protocol are not included in this report).The QDF data were collected at baseline, 6 months, 1, 2 and 3 years through two self administered questionnaires (KCCQ, GDS), while the MMSE only for patients70 years. The questionnaires were administered to the patients who accepted to participate. A specific goal of the project focuses on the degree of independence between the results of the questionnaires and the judgement of the nurses. This contribution presents the operational implementation of the study protocol and general framework.

Published
2009

3. [Quality of life, depression and cognitive functions 2. Methodological aspects and data quality]

Author

Rete Infermieri GISSI HF, Di Giulio P, Pera C, Scarano M, Ferri B, Lepore V, Miani D, Tognoni G, Rosson V, Serafini C, Zumino MT, Partemi L, Falleroni ML, Moretti L, Porta L, Santorsola A, Tenerelli T, Bertoncelli B, Mengoli G, Stagnitto M, Puddu GM, Masini E, Pasini A, Boni S, Valsesia E, Cornacini G, Melis D, Mulina A, Giurlanda A, Fava M, Bellini P, Vallucci S, Cuomo A, Campanale S, Monatti G, Bianco T, Milli V, Antonelli L, Fanin L, Faiola L, Stefanizzi R, Mariani M, Rossi A, Regnani ST, Loreni F, Cianfrocca R, Pisani A, Faraolfi V, Ponzalli P, Savli T, Cresci M, Guardalben S, Belluzzo B, Ruberti R, Zizzi M, Tonda C, Cadrobbi MG, Gilardi R, Mondì A, Costa A, Milan S, Zottarelli A, Parodi B, Sartorio N, Rossin B, Santi A, Cagnan P, Maradei E, Cauteruccio A, Carpino C, Addeo R, Izzo A, Amendola G, Prizzitano AM, Piluso GM, Iadevaio AL, Cinà MT, Cirrincione V, Gumina S, Codato G, Raimondo F, Capiello MG, Creta F, Barbieri M, Chiarella L, Abbondio L, Piccin M, Spillone V, Cutrupi G, Ruggeri A, Sicilia G, Provengano A, Marcari P, Ricci S, Pazzagli E, La Grotteria M, Orsini R, Leandri L, Vetere NA, Braggion E, Giordanino S, Armando S, Zampieri E, Danese MC, Valentini A, Ferrante MG, Santacroce C, Crocetti I, Macchi F, Bernacchi M, Pini D, Varì M, Lucente M, Scaramastra F, Reichardt S, Gabasio S, Zocchi C, Studhika M, Budzowska E, Cescon M, Lazzari D, Prizzon A, Di Biaggio P, Buda C, Mastrangelo V, Avigliano M, Dell'Aquila L, Bonanomi E, Mezzani A, Porcini F, Girardi G., PERRONE FILARDI, PASQUALE, Rete Infermieri GISSI, Hf, Di Giulio, P, Pera, C, Scarano, M, Ferri, B, Lepore, V, Miani, D, Tognoni, G, Rosson, V, Serafini, C, Zumino, Mt, Partemi, L, Falleroni, Ml, Moretti, L, Porta, L, Santorsola, A, Tenerelli, T, Bertoncelli, B, Mengoli, G, Stagnitto, M, Puddu, Gm, Masini, E, Pasini, A, Boni, S, Valsesia, E, Cornacini, G, Melis, D, Mulina, A, Giurlanda, A, Fava, M, Bellini, P, Vallucci, S, Cuomo, A, Campanale, S, Monatti, G, Bianco, T, Milli, V, Antonelli, L, Fanin, L, Faiola, L, Stefanizzi, R, Mariani, M, Rossi, A, Regnani, St, Loreni, F, Cianfrocca, R, Pisani, A, Faraolfi, V, Ponzalli, P, Savli, T, Cresci, M, Guardalben, S, Belluzzo, B, Ruberti, R, Zizzi, M, Tonda, C, Cadrobbi, Mg, Gilardi, R, Mondì, A, Costa, A, Milan, S, Zottarelli, A, Parodi, B, Sartorio, N, Rossin, B, Santi, A, Cagnan, P, Maradei, E, Cauteruccio, A, Carpino, C, Addeo, R, Izzo, A, Amendola, G, PERRONE FILARDI, Pasquale, Prizzitano, Am, Piluso, Gm, Iadevaio, Al, Cinà, Mt, Cirrincione, V, Gumina, S, Codato, G, Raimondo, F, Capiello, Mg, Creta, F, Barbieri, M, Chiarella, L, Abbondio, L, Piccin, M, Spillone, V, Cutrupi, G, Ruggeri, A, Sicilia, G, Provengano, A, Marcari, P, Ricci, S, Pazzagli, E, La Grotteria, M, Orsini, R, Leandri, L, Vetere, Na, Braggion, E, Giordanino, S, Armando, S, Zampieri, E, Danese, Mc, Valentini, A, Ferrante, Mg, Santacroce, C, Crocetti, I, Macchi, F, Bernacchi, M, Pini, D, Varì, M, Lucente, M, Scaramastra, F, Reichardt, S, Gabasio, S, Zocchi, C, Studhika, M, Budzowska, E, Cescon, M, Lazzari, D, Prizzon, A, Di Biaggio, P, Buda, C, Mastrangelo, V, Avigliano, M, Dell'Aquila, L, Bonanomi, E, Mezzani, A, Porcini, F, and Girardi, G.

Subjects
Depression, Patient Selection, Cardiology, Middle Aged, Prognosis, Nursing Research, Cognition, Italy, Surveys and Questionnaires, Quality of Life, Humans, Multicenter Studies as Topic, Cardiomyopathies, Geriatric Assessment, Aged, Randomized Controlled Trials as Topic
Abstract

To document the degree of reliability of validated and mainly qualitative questionnaires most often used in research settings and/or projects, in a broad network of unselected cardiological centres; to assess whether the quality of data could be compatible with their use not only as descriptive but also in prognostic scores including mainly "hard" clinical variables.Eighty-three patients were included. Compliance with the self-administration of the Kansas City Cardiomiopathy Questionnaire (KCCQ) and the Geriatric Depression Scale (GDS) was very high throughout the study (KCCQ 97.7% baseline and 85.8% at three years). As expected more difficulties were encountered with the Mini Mental State Examination (administered to 80.6% patients baseline and to 54.3% at three years). Main reasons for not administering questionnaires was ascribed to organizational and patients problems.It is worth noticing that the study was conducted by nurses without economical incentives. The questionnaires were well completed with minimal missing data. If questionnaires are well presented to patients, a routine assessment of quality of life and depression could be feasible in everyday care.

Published
2009

4. [Quality of life, depression and cognitive functions 4. Quality of life]

Author

Rete Infermieri GISSI HF, Di Giulio P, Pera C, Scarano M, Ferri B, Lepore V, Miani D, Tognoni G, Rosson V, Serafini C, Zumino MT, Partemi L, Falleroni ML, Moretti L, Porta L, Santorsola A, Tenerelli T, Bertoncelli B, Mengoli G, Stagnitto M, Puddu GM, Masini E, Pasini A, Boni S, Valsesia E, Cornacini G, Melis D, Mulina A, Giurlanda A, Fava M, Bellini P, Vallucci S, Cuomo A, Campanale S, Monatti G, Bianco T, Milli V, Antonelli L, Fanin L, Faiola L, Stefanizzi R, Mariani M, Rossi A, Regnani ST, Loreni F, Cianfrocca R, Pisani A, Faraolfi V, Ponzalli P, Savli T, Cresci M, Guardalben S, Belluzzo B, Ruberti R, Zizzi M, Tonda C, Cadrobbi MG, Gilardi R, Mondì A, Costa A, Milan S, Zottarelli A, Parodi B, Sartorio N, Rossin B, Santi A, Cagnan P, Maradei E, Cauteruccio A, Carpino C, Addeo R, Izzo A, Amendola G, Prizzitano AM, Piluso GM, Iadevaio AL, Cinà MT, Cirrincione V, Gumina S, Codato G, Raimondo F, Capiello MG, Creta F, Barbieri M, Chiarella L, Abbondio L, Piccin M, Spillone V, Cutrupi G, Ruggeri A, Sicilia G, Provengano A, Marcari P, Ricci S, Pazzagli E, La Grotteria M, Orsini R, Leandri L, Vetere NA, Braggion E, Giordanino S, Armando S, Zampieri E, Danese MC, Valentini A, Ferrante MG, Santacroce C, Crocetti I, Macchi F, Bernacchi M, Pini D, Varì M, Lucente M, Scaramastra F, Reichardt S, Gabasio S, Zocchi C, Studhika M, Budzowska E, Cescon M, Lazzari D, Prizzon A, Di Baggio P, Buda C, Mastrangelo V, Avigliano M, Dell'Aquila L, Bonanomi E, Mezzani A, Porcini F, Girardi G., PERRONE FILARDI, PASQUALE, Rete Infermieri GISSI, Hf, Di Giulio, P, Pera, C, Scarano, M, Ferri, B, Lepore, V, Miani, D, Tognoni, G, Rosson, V, Serafini, C, Zumino, Mt, Partemi, L, Falleroni, Ml, Moretti, L, Porta, L, Santorsola, A, Tenerelli, T, Bertoncelli, B, Mengoli, G, Stagnitto, M, Puddu, Gm, Masini, E, Pasini, A, Boni, S, Valsesia, E, Cornacini, G, Melis, D, Mulina, A, Giurlanda, A, Fava, M, Bellini, P, Vallucci, S, Cuomo, A, Campanale, S, Monatti, G, Bianco, T, Milli, V, Antonelli, L, Fanin, L, Faiola, L, Stefanizzi, R, Mariani, M, Rossi, A, Regnani, St, Loreni, F, Cianfrocca, R, Pisani, A, Faraolfi, V, Ponzalli, P, Savli, T, Cresci, M, Guardalben, S, Belluzzo, B, Ruberti, R, Zizzi, M, Tonda, C, Cadrobbi, Mg, Gilardi, R, Mondì, A, Costa, A, Milan, S, Zottarelli, A, Parodi, B, Sartorio, N, Rossin, B, Santi, A, Cagnan, P, Maradei, E, Cauteruccio, A, Carpino, C, Addeo, R, Izzo, A, Amendola, G, PERRONE FILARDI, Pasquale, Prizzitano, Am, Piluso, Gm, Iadevaio, Al, Cinà, Mt, Cirrincione, V, Gumina, S, Codato, G, Raimondo, F, Capiello, Mg, Creta, F, Barbieri, M, Chiarella, L, Abbondio, L, Piccin, M, Spillone, V, Cutrupi, G, Ruggeri, A, Sicilia, G, Provengano, A, Marcari, P, Ricci, S, Pazzagli, E, La Grotteria, M, Orsini, R, Leandri, L, Vetere, Na, Braggion, E, Giordanino, S, Armando, S, Zampieri, E, Danese, Mc, Valentini, A, Ferrante, Mg, Santacroce, C, Crocetti, I, Macchi, F, Bernacchi, M, Pini, D, Varì, M, Lucente, M, Scaramastra, F, Reichardt, S, Gabasio, S, Zocchi, C, Studhika, M, Budzowska, E, Cescon, M, Lazzari, D, Prizzon, A, Di Baggio, P, Buda, C, Mastrangelo, V, Avigliano, M, Dell'Aquila, L, Bonanomi, E, Mezzani, A, Porcini, F, and Girardi, G.

Subjects
Male, Depression, Cardiology, Prognosis, Hospitalization, Nursing Research, Cognition, Italy, Risk Factors, Data Interpretation, Statistical, Surveys and Questionnaires, Quality of Life, Humans, Female, Mortality, Cardiomyopathies, Aged, Randomized Controlled Trials as Topic
Abstract

Aim of this paper is to explore and quanti-quantitatively assess whether QoL as measured with the Kansas City Cardiomiopathy Questionnaire (KCCQ) summary score could be considered as an independent relevant component of clinical prognostic score of morbidity and mortality and identify patients at risk for death or admissions.Sixty-three per cent NYHA II and 39.4% NYHA III-IV patients experience a good Qol (score75). Risk factors for "not good" (75) QoL are age, NYHA class III-IV, diabetes, COPD and previous hospitalizations. NYHA II and III-IV patients with not good QoL experience an higher mortality than patients with a good QoL in the same classes. NYHA II patients with not good QoL experience the same 1 year readmission rates as NYHA III-IV patients with good QoL.Quality of life scores identify patients with different risk of mortality and readmissions within the same NYHA class. The prognostic value of KCCQ summary scores could identify candidates for disease management in whom better targeted care strategies may reduce hospitalizations and prevent deaths.

Published
2009

5. [Quality of life, depression and cognitive functions 3. The main characteristics of the QDF study population]

Author

Rete Infermieri GISSI HF, Di Giulio P, Pera C, Scarano M, Ferri B, Lepore V, Miani D, Tognoni G, Rosson V, Serafini C, Zumino MT, Partemi L, Falleroni ML, Moretti L, Porta L, Santorsola A, Tenerelli T, Bertoncelli B, Mengoli G, Stagnitto M, Puddu GM, Masini E, Pasini A, Boni S, Valsesia E, Cornacini G, Melis D, Mulina A, Giurlanda A, Fava M, Bellini P, Vallucci S, Cuomo A, Campanale S, Monatti G, Bianco T, Milli V, Antonelli L, Fanin L, Faiola L, Stefanizzi R, Mariani M, Rossi A, Regnani ST, Loreni F, Cianfrocca R, Pisani A, Faraolfi V, Ponzalli P, Savli T, Cresci M, Guardalben S, Belluzzo B, Ruberti R, Zizzi M, Tonda C, Cadrobbi MG, Gilardi R, Mondì A, Costa A, Milan S, Zottarelli A, Parodi B, Sartorio N, Rossin B, Santi A, Cagnan P, Maradei E, Cauteruccio A, Carpino C, Addeo R, Izzo A, Amendola G, Prizzitano AM, Piluso GM, Iadevaio AL, Cinà MT, Cirrincione V, Gumina S, Codato G, Raimondo F, Cappiello MG, Creta F, Barbieri M, Chiarella L, Abbondio L, Piccin M, Spillone V, Cutrupi G, Ruggeri A, Sicilia G, Provengano A, Marcari P, Ricci S, Pazzagli E, La Grotteria M, Orsini R, Leandri L, Vetere NA, Braggion E, Giordanino S, Armando S, Zampieri E, Danese MC, Valentini A, Ferrante MG, Santacroce C, Crocetti I, Macchi F, Bernacchi M, Pini D, Varì M, Lucente M, Scaramastra F, Reichardt S, Gabasio S, Zocchi C, Studhika M, Budzowska E, Cescon M, Lazzari D, Prizzon A, Di Biaggio P, Buda C, Mastrangelo V, Avigliano M, Dell'Aquila L, Bonanomi E, Mezzani A, Porcini F, Girardi G., PERRONE FILARDI, PASQUALE, Rete Infermieri GISSI, Hf, Di Giulio, P, Pera, C, Scarano, M, Ferri, B, Lepore, V, Miani, D, Tognoni, G, Rosson, V, Serafini, C, Zumino, Mt, Partemi, L, Falleroni, Ml, Moretti, L, Porta, L, Santorsola, A, Tenerelli, T, Bertoncelli, B, Mengoli, G, Stagnitto, M, Puddu, Gm, Masini, E, Pasini, A, Boni, S, Valsesia, E, Cornacini, G, Melis, D, Mulina, A, Giurlanda, A, Fava, M, Bellini, P, Vallucci, S, Cuomo, A, Campanale, S, Monatti, G, Bianco, T, Milli, V, Antonelli, L, Fanin, L, Faiola, L, Stefanizzi, R, Mariani, M, Rossi, A, Regnani, St, Loreni, F, Cianfrocca, R, Pisani, A, Faraolfi, V, Ponzalli, P, Savli, T, Cresci, M, Guardalben, S, Belluzzo, B, Ruberti, R, Zizzi, M, Tonda, C, Cadrobbi, Mg, Gilardi, R, Mondì, A, Costa, A, Milan, S, Zottarelli, A, Parodi, B, Sartorio, N, Rossin, B, Santi, A, Cagnan, P, Maradei, E, Cauteruccio, A, Carpino, C, Addeo, R, Izzo, A, Amendola, G, PERRONE FILARDI, Pasquale, Prizzitano, Am, Piluso, Gm, Iadevaio, Al, Cinà, Mt, Cirrincione, V, Gumina, S, Codato, G, Raimondo, F, Cappiello, Mg, Creta, F, Barbieri, M, Chiarella, L, Abbondio, L, Piccin, M, Spillone, V, Cutrupi, G, Ruggeri, A, Sicilia, G, Provengano, A, Marcari, P, Ricci, S, Pazzagli, E, La Grotteria, M, Orsini, R, Leandri, L, Vetere, Na, Braggion, E, Giordanino, S, Armando, S, Zampieri, E, Danese, Mc, Valentini, A, Ferrante, Mg, Santacroce, C, Crocetti, I, Macchi, F, Bernacchi, M, Pini, D, Varì, M, Lucente, M, Scaramastra, F, Reichardt, S, Gabasio, S, Zocchi, C, Studhika, M, Budzowska, E, Cescon, M, Lazzari, D, Prizzon, A, Di Biaggio, P, Buda, C, Mastrangelo, V, Avigliano, M, Dell'Aquila, L, Bonanomi, E, Mezzani, A, Porcini, F, and Girardi, G.

Subjects
Aged, 80 and over, Male, Depression, Age Factors, Cardiology, Prognosis, Education, Nursing Research, Cognition, Sex Factors, Italy, Surveys and Questionnaires, Quality of Life, Humans, Female, Cardiomyopathies, Aged, Randomized Controlled Trials as Topic
Abstract

This contribution describes the patients included for the QDF (Quality of life, Depression and Cognitive functions) study and explores the distribution and time trends of scores of the three dimensions.The large majority of patients are males (78.3%), and mean age is 67.2 +/- 10.7 years (9.2%80 years). Patients in NYHA class III-IV experience more depression and a worse QoL as compared to the less severly clinically affected counterparts in NYHA class. Although QoL and depression are influenced by the same variables, not all patients with bad QoL are depressed and viceversa. Mean scores of cognitive functioning are not influenced by the same variables that influence QoL and depression.The regular measurement of QoL, depression and cognitive function is recommended by some authors. It seems to be confirmed that the three dimensions need to be explored to disentangle the specific informative value that each of them could add to clinical measures.

Published
2009

6. [Quality of life, depression and cognitive functions 6. Cognitive functions]

Author

Rete Infermieri GISSI HF, Di Giulio P, Pera C, Scarano M, Ferri B, Lepore V, Miani D, Tognoni G, Rosson V, Serafini C, Zumino MT, Partemi L, Falleroni ML, Moretti L, Porta L, Santorsola A, Tenerelli T, Bertoncelli B, Mengoli G, Stagnitto M, Puddu GM, Masini E, Pasini A, Boni S, Valsesia E, Cornacini G, Melis D, Mulina A, Giurlanda A, Fava M, Bellini P, Vallucci S, Cuomo A, Campanale S, Monatti G, Bianco T, Milli V, Antonelli L, Fanin L, Faiola L, Stefanizzi R, Mariani M, Rossi A, Regnani ST, Loreni F, Cianfrocca R, Pisani A, Faraolfi V, Ponzalli P, Savli T, Cresci M, Guardalben S, Belluzzo B, Ruberti R, Zizzi M, Tonda C, Cadrobbi MG, Gilardi R, Mondì A, Costa A, Milan S, Zottarelli A, Parodi B, Sartorio N, Rossin B, Santi A, Cagnan P, Maradei E, Cauteruccio A, Carpino C, Addeo R, Izzo A, Amendola G, Prizzitano AM, Piluso GM, Iadevaio AL, Cinà MT, Cirrincione V, Gumina S, Codato G, Raimondo F, Cappiello MG, Creta F, Barbieri M, Chiarella L, Abbondio L, Piccin M, Spillone V, Cutrupi G, Ruggeri A, Sicilia G, Provengano A, Marcari P, Ricci S, Pazzagli E, La Grotteria M, Orsini R, Leandri L, Vetere NA, Braggion E, Giordanino S, Armando S, Zampieri E, Danese MC, Valentini A, Ferrante MG, Santacroce C, Crocetti I, Macchi F, Bernacchi M, Pini D, Varì M, Lucente M, Scaramastra F, Reichardt S, Gabasio S, Zocchi C, Studhika M, Budzowska E, Cescon M, Lazzari D, Prizzon A, Di Biaggio P, Buda C, Mastrangelo V, Avigliano M, Dell'Aquila L, Bonanomi E, Mezzani A, Porcini F, Girardi G., PERRONE FILARDI, PASQUALE, Rete Infermieri GISSI, Hf, Di Giulio, P, Pera, C, Scarano, M, Ferri, B, Lepore, V, Miani, D, Tognoni, G, Rosson, V, Serafini, C, Zumino, Mt, Partemi, L, Falleroni, Ml, Moretti, L, Porta, L, Santorsola, A, Tenerelli, T, Bertoncelli, B, Mengoli, G, Stagnitto, M, Puddu, Gm, Masini, E, Pasini, A, Boni, S, Valsesia, E, Cornacini, G, Melis, D, Mulina, A, Giurlanda, A, Fava, M, Bellini, P, Vallucci, S, Cuomo, A, Campanale, S, Monatti, G, Bianco, T, Milli, V, Antonelli, L, Fanin, L, Faiola, L, Stefanizzi, R, Mariani, M, Rossi, A, Regnani, St, Loreni, F, Cianfrocca, R, Pisani, A, Faraolfi, V, Ponzalli, P, Savli, T, Cresci, M, Guardalben, S, Belluzzo, B, Ruberti, R, Zizzi, M, Tonda, C, Cadrobbi, Mg, Gilardi, R, Mondì, A, Costa, A, Milan, S, Zottarelli, A, Parodi, B, Sartorio, N, Rossin, B, Santi, A, Cagnan, P, Maradei, E, Cauteruccio, A, Carpino, C, Addeo, R, Izzo, A, Amendola, G, PERRONE FILARDI, Pasquale, Prizzitano, Am, Piluso, Gm, Iadevaio, Al, Cinà, Mt, Cirrincione, V, Gumina, S, Codato, G, Raimondo, F, Cappiello, Mg, Creta, F, Barbieri, M, Chiarella, L, Abbondio, L, Piccin, M, Spillone, V, Cutrupi, G, Ruggeri, A, Sicilia, G, Provengano, A, Marcari, P, Ricci, S, Pazzagli, E, La Grotteria, M, Orsini, R, Leandri, L, Vetere, Na, Braggion, E, Giordanino, S, Armando, S, Zampieri, E, Danese, Mc, Valentini, A, Ferrante, Mg, Santacroce, C, Crocetti, I, Macchi, F, Bernacchi, M, Pini, D, Varì, M, Lucente, M, Scaramastra, F, Reichardt, S, Gabasio, S, Zocchi, C, Studhika, M, Budzowska, E, Cescon, M, Lazzari, D, Prizzon, A, Di Biaggio, P, Buda, C, Mastrangelo, V, Avigliano, M, Dell'Aquila, L, Bonanomi, E, Mezzani, A, Porcini, F, and Girardi, G.

Subjects
Aged, 80 and over, Heart Failure, Male, Time Factors, Depression, Cardiology, Prognosis, Education, Hospitalization, Nursing Research, Sex Factors, Italy, Risk Factors, Prevalence, Quality of Life, Humans, Female, Mortality, Cognition Disorders, Aged, Randomized Controlled Trials as Topic
Abstract

The prevalence of cognitive impairment (CI) is reported to be higher in heart failure patients than in the general population.To describe the prevalence of CI and to assess its prognostic value on the increased risk of hospitalizations and death over the medium term (3 years).MMSE was administered to 620/745 heart failure patients70 years. Up to 35% of the tested population were classified as mild CI and 12% as moderate. The severity of baseline clinical conditions, as expressed as NYHA classes, do not appear to be associated to different degrees of CI. The subgroup of patients with moderate CI includes higher proportion of people with the lowest educational level, of feminine gender, of higher age (80). Even in a population closely monitored as the one included in the GISSI-HLF trial, it is worth to be underlined that the presence of moderate CI appears to be strongly prognostic of an increased burden of care (hospitalizations), and of death over the whole observation period of the study (3 years).The presence of even mild or moderate CI is prognostic for increased mortality and readmissions for patients of the same NYHA class. In the absence of effective intervention strategies, research should concentrate on the yield, if any, of a systematic screening for CI in heart failure patients.

Published
2009

7. [Quality of life, depression and cognitive functions 5. Depression]

Author

Rete Infermieri GISSI HF, Di Giulio P, Pera C, Scarano M, Ferri B, Lepore V, Miani D, Tognoni G, Rosson V, Serafini C, Zumino MT, Partemi L, Falleroni ML, Moretti L, Porta L, Santorsola A, Tenerelli T, Bertoncelli B, Mengoli G, Stagnitto M, Puddu GM, Masini E, Pasini A, Boni S, Valsesia E, Cornacini G, Melis D, Mulina A, Giurlanda A, Fava M, Bellini P, Vallucci S, Cuomo A, Campanale S, Monatti G, Bianco T, Milli V, Antonelli L, Fanin L, Faiola L, Stefanizzi R, Mariani M, Rossi A, Regnani ST, Loreni F, Cianfrocca R, Pisani A, Faraolfi V, Ponzalli P, Savli T, Cresci M, Guardalben S, Belluzzo B, Ruberti R, Zizzi M, Tonda C, Cadrobbi MG, Gilardi R, Mondì A, Costa A, Milan S, Zottarelli A, Parodi B, Sartorio N, Rossin B, Santi A, Cagnan P, Maradei E, Cauteruccio A, Carpino C, Addeo R, Izzo A, Amendola G, Prizzitano AM, Piluso GM, Iadevaio AL, Cinà MT, Cirrincione V, Gumina S, Codato G, Raimondo F, Cappiello MG, Creta F, Barbieri M, Chiarella L, Abbondio L, Piccin M, Spillone V, Cutrupi G, Ruggeri A, Sicilia G, Provengano A, Marcari P, Ricci S, Pazzagli E, La Grotteria M, Orsini R, Leandri L, Vetere NA, Braggion E, Giordanino S, Armando S, Zampieri E, Danese MC, Valentini A, Ferrante MG, Santacroce C, Crocetti I, Macchi F, Bernacchi M, Pini D, Varì M, Lucente M, Scaramastra F, Reichardt S, Gabasio S, Zocchi C, Studhika M, Budzowska E, Cescon M, Lazzari D, Prizzon A, Di Biaggio P, Buda C, Mastrangelo V, Avigliano M, Dell'Aquila L, Bonanomi E, Mezzani A, Porcini F, Girardi G., PERRONE FILARDI, PASQUALE, Rete Infermieri GISSI, Hf, Di Giulio, P, Pera, C, Scarano, M, Ferri, B, Lepore, V, Miani, D, Tognoni, G, Rosson, V, Serafini, C, Zumino, Mt, Partemi, L, Falleroni, Ml, Moretti, L, Porta, L, Santorsola, A, Tenerelli, T, Bertoncelli, B, Mengoli, G, Stagnitto, M, Puddu, Gm, Masini, E, Pasini, A, Boni, S, Valsesia, E, Cornacini, G, Melis, D, Mulina, A, Giurlanda, A, Fava, M, Bellini, P, Vallucci, S, Cuomo, A, Campanale, S, Monatti, G, Bianco, T, Milli, V, Antonelli, L, Fanin, L, Faiola, L, Stefanizzi, R, Mariani, M, Rossi, A, Regnani, St, Loreni, F, Cianfrocca, R, Pisani, A, Faraolfi, V, Ponzalli, P, Savli, T, Cresci, M, Guardalben, S, Belluzzo, B, Ruberti, R, Zizzi, M, Tonda, C, Cadrobbi, Mg, Gilardi, R, Mondì, A, Costa, A, Milan, S, Zottarelli, A, Parodi, B, Sartorio, N, Rossin, B, Santi, A, Cagnan, P, Maradei, E, Cauteruccio, A, Carpino, C, Addeo, R, Izzo, A, Amendola, G, PERRONE FILARDI, Pasquale, Prizzitano, Am, Piluso, Gm, Iadevaio, Al, Cinà, Mt, Cirrincione, V, Gumina, S, Codato, G, Raimondo, F, Cappiello, Mg, Creta, F, Barbieri, M, Chiarella, L, Abbondio, L, Piccin, M, Spillone, V, Cutrupi, G, Ruggeri, A, Sicilia, G, Provengano, A, Marcari, P, Ricci, S, Pazzagli, E, La Grotteria, M, Orsini, R, Leandri, L, Vetere, Na, Braggion, E, Giordanino, S, Armando, S, Zampieri, E, Danese, Mc, Valentini, A, Ferrante, Mg, Santacroce, C, Crocetti, I, Macchi, F, Bernacchi, M, Pini, D, Varì, M, Lucente, M, Scaramastra, F, Reichardt, S, Gabasio, S, Zocchi, C, Studhika, M, Budzowska, E, Cescon, M, Lazzari, D, Prizzon, A, Di Biaggio, P, Buda, C, Mastrangelo, V, Avigliano, M, Dell'Aquila, L, Bonanomi, E, Mezzani, A, Porcini, F, and Girardi, G.

Subjects
Male, Time Factors, Depression, Health Status, Cardiology, Patient Readmission, Hospitalization, Nursing Research, Cognition, Sex Factors, Italy, Risk Factors, Data Interpretation, Statistical, Prevalence, Quality of Life, Humans, Female, Mortality, Geriatric Assessment, Aged, Randomized Controlled Trials as Topic
Abstract

Depression is common in patients with heart failure but its causal and/or prognostic role with respect to the cardiac condition in still a matter of research.To describe the prevalence of depression and to assess its specific prognostic value in terms of increased risk of hospitalizations or death.Overall, 27.5% of 1495 patients experience symptoms of depression. Risk factors for depression are female sex, age70, higher NYHA class, previous hospitalizations and comorbidities. Depressed patients of the same NYHA class are at higher risk for 1 and 3 years mortality and all causes hospital admissions.Depression, assessed with a simple and easy to administer instrument, can add information to clinical variables in the identification of patients at increased risk of mortality and readmissions within the same NYHA class.

Published
2009

9. Optimization of Pyrazole Compounds as Antibiotic Adjuvants Active against Colistin- and Carbapenem-Resistant Acinetobacter baumannii .

Author

Sannio F, Brizzi A, Del Prete R, Avigliano M, Simone T, Pagli C, Ferraro T, De Luca F, Paolino M, Corelli F, Mugnaini C, and Docquier JD

Abstract

The diffusion of antibiotic-resistant, Gram-negative, opportunistic pathogens, an increasingly important global public health issue, causes a significant socioeconomic burden. Acinetobacter baumannii isolates, despite causing a lower number of infections than Enterobacterales, often show multidrug-resistant phenotypes. Carbapenem resistance is also rather common, prompting the WHO to include carbapenem-resistant A. baumannii as a "critical priority" for the discovery and development of new antibacterial agents. In a previous work, we identified several series of compounds showing either direct-acting or synergistic activity against relevant Gram-negative species, including A. baumannii. Among these, two pyrazole compounds, despite being devoid of any direct-acting activity, showed remarkable synergistic activity in the presence of a subinhibitory concentration of colistin on K. pneumoniae and A. baumannii and served as a starting point for the synthesis of new analogues. In this work, a new series of 47 pyrazole compounds was synthesized. Some compounds showed significant direct-acting antibacterial activity on Gram-positive organisms. Furthermore, an evaluation of their activity as potential antibiotic adjuvants allowed for the identification of two highly active compounds on MDR Acinetobacter baumannii , including colistin-resistant isolates. This work confirms the interest in pyrazole amides as a starting point for the optimization of synergistic antibacterial compounds active on antibiotic-resistant, Gram-negative pathogens.

Published
2022
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10. Targeting GNE Myopathy: A Dual Prodrug Approach for the Delivery of N -Acetylmannosamine 6-Phosphate.

Author

Morozzi C, Sedláková J, Serpi M, Avigliano M, Carbajo R, Sandoval L, Valles-Ayoub Y, Crutcher P, Thomas S, and Pertusati F

Subjects
Animals, CHO Cells, Caco-2 Cells, Cell Survival drug effects, Cells, Cultured, Cricetulus, Distal Myopathies metabolism, Distal Myopathies pathology, Dose-Response Relationship, Drug, Hexosamines chemical synthesis, Hexosamines chemistry, Humans, Molecular Structure, N-Acetylneuraminic Acid analysis, Phosphotransferases (Alcohol Group Acceptor) deficiency, Phosphotransferases (Alcohol Group Acceptor) metabolism, Prodrugs chemical synthesis, Prodrugs chemistry, Structure-Activity Relationship, Sugar Phosphates chemical synthesis, Sugar Phosphates chemistry, Distal Myopathies drug therapy, Drug Delivery Systems, Hexosamines pharmacology, Phosphotransferases (Alcohol Group Acceptor) antagonists & inhibitors, Prodrugs pharmacology, Sugar Phosphates pharmacology
Abstract

ProTides comprise an important class of prodrugs currently marketed and developed as antiviral and anticancer therapies. The ProTide technology employs phosphate masking groups capable of providing more favorable druglike properties and an intracellular activation mechanism for enzyme-mediated release of a nucleoside monophosphate. Herein, we describe the application of phosphoramidate chemistry to 1,3,4- O -acetylated N -acetylmannosamine (Ac 3 ManNAc) to deliver ManNAc-6-phosphate (ManNAc-6-P), a critical intermediate in sialic acid biosynthesis. Sialic acid deficiency is a hallmark of GNE myopathy, a rare congenital disorder of glycosylation (CDG) caused by mutations in GNE that limit the production of ManNAc-6-P. Synthetic methods were developed to provide a library of Ac 3 ManNAc-6-phosphoramidates that were evaluated in a series of studies for their potential as a treatment for GNE myopathy. Prodrug 12b showed rapid activation in a carboxylesterase (CPY) enzymatic assay and favorable ADME properties, while also being more effective than ManNAc at increasing sialic acid levels in GNE-deficient cell lines. These results provide a potential platform to address substrate deficiencies in GNE myopathy and other CDGs.

Published
2019
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