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1. Development of a Canadian Guidance for reporting real-world evidence for regulatory and health-technology assessment (HTA) decision-making

Author

Tadrous, Mina, Aves, Theresa, Fahim, Christine, Riad, Jessica, Mittmann, Nicole, Prieto-Alhambra, Daniel, Rivera, Donna R., Chan, Kelvin, Lix, Lisa M., Kent, Seamus, Dawoud, Dalia, Guertin, Jason Robert, McDonald, James Ted, Round, Jeff, Klarenbach, Scott, Stanojevic, Sanja, De Vera, Mary A., Strumpf, Erin, Platt, Robert W., Husein, Farah, Lambert, Laurie, and Hayes, Kaleen N.

Published
2024
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10. Cognitive assessment instruments in randomized controlled trials of stroke from 2011 - present: A scoping review

Author

Sujanthan, Sajeevan, Herlick, Aaron, Aves, Theresa, Haywood, Kirstie, Dainty, Katie, and Swartz, Richard

Subjects
Stroke, Medical Sciences, Neuroscience and Neurobiology, Clinical Endpoints, Medicine and Health Sciences, Life Sciences, Cognitive Assessments, Analytical, Diagnostic and Therapeutic Techniques and Equipment, Randomized Controlled Trials
Abstract

The objective of this scoping review is to identify, characterize, and summarize all RCT’s evaluating cognition in adult stroke survivors from 2011-present.

Published
2022
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11. An international collaborative study to co-produce a patient-reported outcome measure of cardiac arrest survivorship and health-related quality of life (CASHQoL): A protocol for developing the long-form measure

Author

Haywood, Kirstie L., primary, Southern, Charlotte, additional, Tutton, Elizabeth, additional, Swindell, Paul, additional, Ellard, David, additional, Pearson, Nathan A., additional, Parsons, Helen, additional, Couper, Keith, additional, Dainty, Katie N., additional, Agarwal, Sachin, additional, Perkins, Gavin D., additional, Arestedt, Kristofer, additional, Aves, Theresa, additional, Bray, Janet, additional, Brookes, Anne, additional, Callaway, Clifton, additional, Castren, Maaret, additional, Ong, Marcus Eng Hock, additional, Gellis, Katrysha, additional, Goossens, Paulien H., additional, Graesner, Jan-Thorsten, additional, Hartley, Angela, additional, Hoadley, Rob, additional, Israelsson, Johan, additional, Jeffrey, David, additional, Joshi, Vicky, additional, Keeble, Thomas R., additional, Lilja, Gisela, additional, Long, John, additional, Mion, Marco, additional, Morrison, Laurie J., additional, Moulaert, Veronique R.M., additional, Playford, Diane, additional, Sawyer, Kelly, additional, Semeraro, Federico, additional, Smith, Karen, additional, Williams, Barry, additional, and Wylie, Jasmine, additional

Published
2022
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14. Clinical impact of pretreatment human immunodeficiency virus drug resistance in people initiating nonnucleoside reverse transcriptase inhibitor-containing antiretroviral therapy: A systematic review and meta-analysis

Author

Clinical Virology, Medische Microbiologie, MMB, Infection & Immunity, MMB opleiding Arts microbioloog, Bertagnolio, Silvia, Hermans, Lucas, Jordan, Michael R., Avila-Rios, Santiago, Iwuji, Collins, Derache, Anne, Delaporte, Eric, Wensing, Annemarie, Aves, Theresa, Borhan, A. S.M., Leenus, Alvin, Parkin, Neil, Doherty, Meg, Inzaule, Seth, Mbuagbaw, Lawrence, Clinical Virology, Medische Microbiologie, MMB, Infection & Immunity, MMB opleiding Arts microbioloog, Bertagnolio, Silvia, Hermans, Lucas, Jordan, Michael R., Avila-Rios, Santiago, Iwuji, Collins, Derache, Anne, Delaporte, Eric, Wensing, Annemarie, Aves, Theresa, Borhan, A. S.M., Leenus, Alvin, Parkin, Neil, Doherty, Meg, Inzaule, Seth, and Mbuagbaw, Lawrence

Published
2021

15. Clinical Impact of Pretreatment Human Immunodeficiency Virus Drug Resistance in People Initiating Nonnucleoside Reverse Transcriptase Inhibitor–Containing Antiretroviral Therapy: A Systematic Review and Meta-analysis

Author

Bertagnolio, Silvia, primary, Hermans, Lucas, additional, Jordan, Michael R, additional, Avila-Rios, Santiago, additional, Iwuji, Collins, additional, Derache, Anne, additional, Delaporte, Eric, additional, Wensing, Annemarie, additional, Aves, Theresa, additional, Borhan, A S M, additional, Leenus, Alvin, additional, Parkin, Neil, additional, Doherty, Meg, additional, Inzaule, Seth, additional, and Mbuagbaw, Lawrence, additional

Published
2020
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16. 2020 International Consensus on First Aid Science With Treatment Recommendations

Author

Singletary, Eunice M., primary, Zideman, David A., additional, Bendall, Jason C., additional, Berry, David A., additional, Borra, Vere, additional, Carlson, Jestin N., additional, Cassan, Pascal, additional, Chang, Wei- Tien, additional, Charlton, Nathan P., additional, Djärv, Therese, additional, Douma, Matthew J., additional, Epstein, Jonathan L., additional, Hood, Natalie A., additional, Markenson, David S., additional, Meyran, Daniel, additional, Orkin, Aaron, additional, Sakamoto, Tetsuya, additional, Swain, Janel M., additional, Woodin, Jeff A., additional, De Buck, Emmy, additional, De Brier, Niels, additional, O, Dorien, additional, Picard, Christopher, additional, Goolsby, Craig, additional, Oliver, Emily, additional, Klaassen, Barry, additional, Poole, Kurtis, additional, Aves, Theresa, additional, Lin, Steve, additional, Handley, Anthony J., additional, Jensen, Jan, additional, Allan, Katherine S., additional, and Lee, Chien-Chang, additional

Published
2020
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17. Health-Related Quality of Life in Patients With Atrial Fibrillation Treated With Catheter Ablation or Antiarrhythmic Drug Therapy: A Systematic Review and Meta-analysis

Author

Allan, Katherine S., primary, Aves, Theresa, additional, Henry, Shaunattonie, additional, Banfield, Laura, additional, Victor, J. Charles, additional, Dorian, Paul, additional, Healey, Jeff S., additional, Andrade, Jason G., additional, Carroll, Sandra L., additional, and McGillion, Michael H., additional

Published
2020
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18. First aid cooling techniques for heat stroke and exertional hyperthermia: A systematic review and meta-analysis

Author

Douma, Matthew J., primary, Aves, Theresa, additional, Allan, Katherine S., additional, Bendall, Jason C., additional, Berry, David C., additional, Chang, Wei-Tien, additional, Epstein, Jonathan, additional, Hood, Natalie, additional, Singletary, Eunice M., additional, Zideman, David, additional, Lin, Steve, additional, Borra, Vere, additional, Carlson, Jestin N., additional, Cassan, Pascal, additional, Charlton, Nathan P., additional, Markenson, David S., additional, Meyran, Daniel, additional, Sakamoto, Tetsuya, additional, Swain, Janel M., additional, and Woodin, Jeff A., additional

Published
2020
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21. Clinical Impact of Pretreatment Human Immunodeficiency Virus Drug Resistance in People Initiating Nonnucleoside Reverse Transcriptase Inhibitor-Containing Antiretroviral Therapy: A Systematic Review and Meta-analysis.

Author

Bertagnolio, Silvia, Hermans, Lucas, Jordan, Michael R, Avila-Rios, Santiago, Iwuji, Collins, Derache, Anne, Delaporte, Eric, Wensing, Annemarie, Aves, Theresa, Borhan, A S M, Leenus, Alvin, Parkin, Neil, Doherty, Meg, Inzaule, Seth, and Mbuagbaw, Lawrence

Subjects
HIV, REVERSE transcriptase, DRUG resistance, ANTIRETROVIRAL agents, REVERSE transcriptase inhibitors
Abstract

Background: Increased access to antiretroviral therapy (ART) has resulted in rising levels of pretreatment human immunodeficiency virus drug resistance (PDR). This is the first systematic review and meta-analysis to assess the impact of PDR on treatment outcomes among people initiating nonnucleoside reverse transcriptase inhibitor (NNRTI)-based ART, including the combination of efavirenz (EFV), tenofovir (TDF), and lamivudine or emtricitabine (XTC).Methods: We systematically reviewed studies and conference proceedings comparing treatment outcomes in populations initiating NNRTI-based ART with and without PDR. We conducted subgroup analyses by regimen: (1) NNRTIs + 2 nucleoside reverse transcriptase inhibitors (NRTIs), (2) EFV + 2 NRTIs, or (3) EFV/TDF/XTC; by population (children vs adults); and by definition of resistance (PDR vs NNRTI PDR).Results: Among 6197 studies screened, 32 were analyzed (31 441 patients). We found that individuals with PDR initiating NNRTIs across all the subgroups had increased risk of virological failure compared to those without PDR. Risk of acquisition of new resistance mutations and ART switch was also higher in people with PDR.Conclusions: This review shows poorer treatment outcomes in the presence of PDR, supporting the World Health Organization's recommendation to avoid using NNRTIs in countries where levels of PDR are high. [ABSTRACT FROM AUTHOR]

Published
2021
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22. The Role of Pragmatism in Explaining Heterogeneity in Meta-Analyses

Author

Aves, Theresa, Mbuagbaw, Lawrence, and Health Research Methodology

Subjects
Methodological Review, Pragmatic Trials, RITES, PRECIS-2, Systematic Review, Heterogeneity, Meta-Regression
Abstract

Introduction: There has been increasing interest in evidence from pragmatic trials as healthcare providers and decision makers must determine if available evidence can be translated and used in real world practice. As a result, a number of tools have been developed to help researchers design and appraise randomized controlled trials (RCTs) within the pragmatic-explanatory continuum. It is unclear what role pragmatism plays in heterogeneity and if pragmatic and explanatory trials should be pooled in meta-analyses of systematic reviews. Objectives: Our primary objective was to explore the role of pragmatism (based on the Pragmatic-Explanatory Continuum Indicator Summary-2 [PRECIS-2] score) as a source of heterogeneity in Cochrane systematic reviews with at least substantial heterogeneity (I2≥ 50%). Our secondary objective was to compare and contrast the application of the established PRECIS-2 tool to the newly developed Rating of Included Trials on the Efficacy-Effectiveness Spectrum (RITES) tool. Methods: We conducted a cross-sectional methodological review on systematic reviews of RCTs published in the Cochrane Library from January 1, 2014 to January 1, 2017. Included systematic reviews had a minimum of 10 RCTs in the meta-analysis of the primary outcome and at least moderate heterogeneity (I2≥ 50%). Of the eligible systematic reviews, a random selection of 10 were included for quantitative evaluation. In each systematic review, RCTs were scored using the PRECIS-2 and RITES tools, in duplicate, to determine the amount of pragmatism. Meta-regression modelling was performed to evaluate how much variability in heterogeneity (quantified by I2) was due to pragmatism. Inter-rater reliability of both PRECIS-2 and RITES was measured using the intraclass correlation coefficient and Spearman’s correlation coefficient was used to determine the strength of the relation between PRECIS-2 and RITES. Results: Ten systematic reviews from nine Cochrane Review Groups were included in the quantitative analysis. The reviews included an average of 13 RCTs (standard deviation=2.6) for a total of 132 RCTs of which 128 could be obtained. When the PRECIS-2 summary score was entered as a covariate in random effects meta-regression models for each systematic review, there were minimal changes in heterogeneity. The changes in I2 ranged from 0.2% to 13.3%. Conclusion: Based on these findings it appears pragmatism as measured by PRECIS-2 does not explain heterogeneity in systematic reviews, therefore pooling of pragmatic and explanatory RCTs is unlikely to be detrimental to meta-analyses. Thesis Master of Science (MSc) Systematic reviews and meta-analyses of randomized controlled trials (RCTs) are an important scientific activity that can lead to changes in health care. However, there is concern whether it is appropriate to meta-analyze data from RCTs that are performed under more controlled conditions (explanatory RCTs) and RCTs that are performed under more real world conditions (pragmatic RCTs) since there may be variability between them. The purpose of this research was to explore how much these trial types affect variability, otherwise known as heterogeneity, in systematic reviews. We applied a scoring tool called the Pragmatic-Explanatory Continuum Indicator Summary-2 (PRECIS-2) to RCTs within 10 systematic reviews with at least moderate heterogeneity and performed statistical modelling to determine how much heterogeneity could be explained by a trial being more or less pragmatic. Results showed that trial type did not explain heterogeneity therefore it is probably reasonable to meta-analyze data from pragmatic and explanatory RCTs.

Published
2017

25. 747. Antibiotic Therapy for Community-Acquired Pneumonia: A Systematic Review and Network Meta-Analysis of Randomized Trials

Author

Siemieniuk, Reed, primary, Lee, Yung, additional, Bogoch, Isaac, additional, Brignardello-Petersen, Romina, additional, Fei, Yutong, additional, Alexander, Paul, additional, Aves, Theresa, additional, Zeraatkar, Dena, additional, Sadeghirad, Behnam, additional, Li, Xun, additional, Evaniew, Nathan, additional, Bhatnagar, Neera, additional, Rochwerg, Bram, additional, Guyatt, Gordon, additional, and Loeb, Mark, additional

Published
2018
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28. Comparison of health-related quality of life in patients with atrial fibrillation treated with catheter ablation or antiarrhythmic drug therapy: a systematic review and meta-analysis protocol

Author

Allan, Katherine S, primary, Henry, Shaunattonie, additional, Aves, Theresa, additional, Banfield, Laura, additional, Victor, J Charles, additional, Dorian, Paul, additional, Healey, Jeff S, additional, Andrade, Jason, additional, Carroll, Sandra, additional, and McGillion, Michael, additional

Published
2017
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31. Clinically Significant Pocket Hematoma Increases Long-Term Risk of Device Infection

Author

Essebag, Vidal, primary, Verma, Atul, additional, Healey, Jeff S., additional, Krahn, Andrew D., additional, Kalfon, Eli, additional, Coutu, Benoit, additional, Ayala-Paredes, Felix, additional, Tang, Anthony S., additional, Sapp, John, additional, Sturmer, Marcio, additional, Keren, Arieh, additional, Wells, George A., additional, Birnie, David H., additional, Green, Martin, additional, Nery, Pablo, additional, Lemery, Robert, additional, Gollob, Michael, additional, Davis, Darryl, additional, Redpath, Calum, additional, Duchesne, Lloyd, additional, Carlin, Leslie, additional, MacDonald, Karen, additional, Dunne, Rosemary, additional, Fleming, Rochelle, additional, Yeltsir, Elizabeth, additional, Chen, Li, additional, Tran, My-Linh, additional, Coyle, Doug, additional, Hadjis, Tomy, additional, Bernier, Martin L., additional, Omelchenko, Alexander, additional, Rafti, Fiorella, additional, Beaudoin, Johannie, additional, Bureau, Johanne, additional, Coutu, Isabelle, additional, Vaillancourt, Emilie, additional, Manlucu, Jaimie, additional, Yee, Raymond, additional, Skanes, Allan, additional, Gula, Lorne, additional, Klein, George, additional, Leong-Sit, Peter, additional, Nyman, Lynn, additional, Bentley, Cathy, additional, Hulley, Denise, additional, Morillo, Carlos, additional, Connolly, Stuart, additional, Nair, Girish, additional, Divakaramenon, S., additional, Ribas, S., additional, Eikelboom, John, additional, Meyer, Wendy, additional, Malcolm, Victoria, additional, Carroll, Sandra, additional, Simpson, Christopher S., additional, Baranchuk, Adrian, additional, Abdollah, Hashiar, additional, Michael, Kevin, additional, Redfearn, Damian, additional, Hammond, Sharlene, additional, Ewart, Gwen, additional, Fair, Sharon, additional, O’Reilly, Glenda, additional, Novak, Paul, additional, Sterns, Laurence, additional, Leather, Richard, additional, Smith, Reg, additional, Lane, Chris, additional, Bastell, Mona, additional, Parfett, Debbie, additional, Green, Andrea, additional, Jackson, Heather, additional, Basta, Magdy, additional, Gardner, Martin, additional, Parkash, Ratika, additional, Gray, Chris, additional, Fearon, Ann, additional, Giddens, Karen, additional, Carroll, Lisa, additional, Kus, Teresa, additional, Becker, Guiliano, additional, Langlois, Ann, additional, Sirois, Carole, additional, Khaykin, Yaariv, additional, Wulffhart, Zaev, additional, Tsang, Bernice, additional, Pantano, Alfredo, additional, Winger, Kellie, additional, Patterson, Sherri, additional, Nath, Annette, additional, Seifer, Colette, additional, Wolfe, Kevin, additional, Khadem, Ali, additional, Tischenko, Alex, additional, Polson, Jan, additional, Roux, Jean-Francois, additional, Badra, Mariano, additional, Cote, Stephanie, additional, Lavallee, Lyne, additional, Houde, Rene, additional, Crystal, Eugene, additional, Lashevsky, Ilan, additional, Lau, Ching, additional, Laish-Farkash, Avishag, additional, Costa Vitali, Atilio, additional, Singh, Sheldon, additional, Tiong, Irving, additional, Ahmadzai, Fahema, additional, Khurana, Mamta, additional, Lakhanpal, Meena, additional, Lukomsky, Maria, additional, Shurrab, Mohammed, additional, Costi, Paolo, additional, Greiss, Isabelle, additional, Mansour, Fadi, additional, Raymond, Jean-Marc, additional, Bergeron, Martine, additional, Roby, Nancy, additional, Ahmad, Kamran, additional, Dorian, Paul, additional, Mangat, Iqwal, additional, Korley, Victoria, additional, Pinter, Arnold, additional, Aves, Theresa, additional, Mariano, Zana, additional, Estacio, Antonio, additional, Rinne, Claus, additional, Janzen, Irene, additional, Lowery, Donna, additional, Kenyon, Naomi, additional, Jonson, Kaler, additional, Toal, Satish, additional, Stevenson, Robert, additional, Searles, Gregory, additional, Douglas, Geoffrey, additional, Bessoudo, Ricardo, additional, Hassan, Ansar, additional, Collings, Elizabeth, additional, Braam, Corinne, additional, Fitzgerald, Fabia, additional, Kent, Donna, additional, Mychaluk, Luana, additional, Kavanagh, Katherine, additional, Exner, Derek, additional, Burgess, John, additional, Rothschild, John, additional, Kuriachan, Vikas, additional, Sumner, Glen Linnell, additional, Keller, Debbie, additional, Yuen, Brian, additional, Jackson-Carter, Leslie, additional, Dorey, Sandra, additional, Leiria, Tiago L.L., additional, Sant’Anna, Roberto Tofani, additional, de March Ronsoni, Rafail, additional, Pereira, M.A. Moraes, additional, Moraes, Antonieta, additional, and Rodrigues, Juliane, additional

Published
2016
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34. Rhythm and rate control of atrial fibrillation in the emergency department – A large community-based observational study

Author

Gilbert, Cameron J., Angaran, Paul, Mariano, Zana, Aves, Theresa, and Dorian, Paul

Abstract

AbstractObjectiveAtrial fibrillation (AF) is the most common arrhythmia presentation to the emergency department (ED) and frequently results in admission to the hospital. Although rarely life-threatening and not usually an emergent condition, AF places a large burden on our health-care system. The objective of this study was to describe the practices of ED physicians in the management of AF in a large urban Canadian city.MethodsFrom January 1, 2010 to December 31, 2010, patients with a primary diagnosis of AF were identified across 10 EDs in Toronto, Canada (N=2,609). Fifty patients were selected at random from each hospital for a detailed chart review (n=500).ResultsTwo hundred thirty-two patients (46%) received rate control, and 129 (26%) received rhythm control with the remainder (28%) receiving neither therapy. Sixty-seven percent of patients were discharged home. Most patients (79%) were symptomatic on arrival; however, only a minority of these (31%) received rhythm control. Factors that were associated with rhythm control included younger age, duration of palpitations ≤ 48 hours, a lower CHADS2 score, and the absence of left ventricular dysfunction.ConclusionOur data suggest a wide range of practice amongst ED physicians treating patients presenting to the ED with a primary diagnosis of AF. A randomized trial is needed to better understand the optimal management strategy in this patient population and setting.

Published
2018
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36. Mexiletine as an Adjunctive Therapy to Amiodarone Reduces the Frequency of Ventricular Tachyarrhythmia Events in Patients With an Implantable Defibrillator

Author

Gao, Dongsheng, primary, Van Herendael, Hugo, additional, Alshengeiti, Lamia, additional, Dorian, Paul, additional, Mangat, Iqwal, additional, Korley, Victoria, additional, Ahmad, Kamran, additional, Golovchiner, Gregory, additional, Aves, Theresa, additional, and Pinter, Arnold, additional

Published
2013
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39. Meta-analysis of Pragmatic and Explanatory Trials.

Author

Mbuagbaw L and Aves T

Subjects
Research Design
Abstract

Pooling studies with different clinical and methodological features may lead to statistical heterogeneity, particularly if heterogeneity remains unexplained. One potential source of heterogeneity may be how much the included trials tend toward a pragmatic or explanatory design. Many tools have been developed to aid researchers in quantifying pragmatism in clinical trials, at both the design and appraisal stages.In this chapter we review these tools, illustrate examples of their use, and discuss methods of including pragmatism in meta-analysis as a way of exploring heterogeneity.We suggest a stepwise approach to incorporating evidence from pragmatic and explanatory trials which includes planning to assess pragmatism at the protocol stage, collecting data on pragmatism, extracting data on treatment effects, incorporating pragmatism in meta-analysis using subgroup analysis or meta-regression techniques, and interpreting and reporting the findings transparently., (© 2022. Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2022
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