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1,234 results on '"Avanzini, P."'

1. First results on new helium based eco-gas mixtures for the Extreme Energy Events Project

Author: Abbrescia, M., Avanzini, C., Baldini, L., Ferroli, R. Baldini, Batignani, G., Battaglieri, M., Boi, S., Bossini, E., Carnesecchi, F., Cavazza, F., Cicalò, C., Cifarelli, L., Coccetti, F., Coccia, E., Corvaglia, A., De Gruttola, D., De Pasquale, S., Galante, L., Garbini, M., Gnesi, I., Gramegna, F., Grazzi, S., Hatzifotiadou, D., La Rocca, P., Liu, Z., Mandaglio, G., Margotti, A., Maron, G., Mazziotta, M. N., Mulliri, A., Nania, R., Noferini, F., Nozzoli, F., Palmonari, F., Panareo, M., Panetta, M. P., Paoletti, R., Pellegrino, C., Perasso, L., Pinazza, O., Pinto, C., Pisano, S., Riggi, F., Righini, G., Ripoli, C., Rizzi, M., Sartorelli, G., Scapparone, E., Schioppa, M., Scioli, G., Scribano, A., Selvi, M., Taiuti, M., Terreni, G., Trifirò, A., Trimarchi, M., Vistoli, C., Votano, L., Williams, M. C. S., Zichichi, A., and Zuyeuski, R.
Subjects: High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract: The Extreme Energy Events (EEE) Project, a joint project of the Centro Fermi (Museo Storico della Fisica e Centro Studi e Ricerche "E.Fermi") and INFN, has a dual purpose: a scientific research program on cosmic rays at ground level and an intense outreach and educational program. The project consists in a network of about 60 tracking detectors, called telescopes, mostly hosted in Italian High Schools. Each telescope is made by three Multigap Resistive Plate Chambers, operated so far with a gas mixture composed by 98% C$_2$H$_2$F$_4$ and 2% SF$_6$. Due to its high Global Warming Potential, a few years ago the EEE collaboration has started an extensive R&D on alternative mixtures environmentally sustainable and compatible with the current experimental setup and operational environment. Among other gas mixtures, the one with helium and hydrofluoroolefin R1234ze gave the best result during the preliminary tests performed with two of the network telescopes. The detector has proved to reach performance levels comparable to those obtained with previous mixtures, without any modification of the hardware. We will discuss the first results obtained with the new mixture, tested with different percentages of the two components., Comment: 14 pages, 6 figures, submitted to JINST
Published: 2024

2. A quantitative probabilistic relational Hoare logic

Author: Avanzini, Martin, Barthe, Gilles, Davoli, Davide, and Grégoire, Benjamin
Subjects: Computer Science - Logic in Computer Science
Abstract: We introduce eRHL, a program logic for reasoning about relational expectation properties of pairs of probabilistic programs. eRHL is quantitative, i.e., its pre- and post-conditions take values in the extended non-negative reals. Thanks to its quantitative assertions, eRHL overcomes randomness alignment restrictions from prior logics, including PRHL, a popular relational program logic used to reason about security of cryptographic constructions, and apRHL, a variant of PRHL for differential privacy. As a result, eRHL is the first relational probabilistic program logic to be supported by non-trivial soundness and completeness results for all almost surely terminating programs. We show that eRHL is sound and complete with respect to program equivalence, statistical distance, and differential privacy. We also show that every PRHL judgment is valid iff it is provable in eRHL. We showcase the practical benefits of eRHL with examples that are beyond reach of PRHL and apRHL.
Published: 2024

3. Nonequilibrium Thermodynamics of Non-Ideal Reaction-Diffusion Systems: Implications for Active Self-Organization

Author: Avanzini, Francesco, Aslyamov, Timur, Fodor, Étienne, and Esposito, Massimiliano
Subjects: Quantitative Biology - Molecular Networks, Condensed Matter - Statistical Mechanics
Abstract: We develop a framework describing the dynamics and thermodynamics of open non-ideal reaction-diffusion systems, which embodies Flory-Huggins theories of mixtures and chemical reaction network theories. Our theory elucidates the mechanisms underpinning the emergence of self-organized dissipative structures in these systems. It evaluates the dissipation needed to sustain and control them, discriminating the contributions from each reaction and diffusion process with spatial resolution. It also reveals the role of the reaction network in powering and shaping these structures. We identify particular classes of networks in which diffusion processes always equilibrate within the structures, while dissipation occurs solely due to chemical reactions. The spatial configurations resulting from these processes can be derived by minimizing a kinetic potential, contrasting with the minimization of the thermodynamic free energy in passive systems. This framework opens the way to investigating the energetic cost of phenomena such as liquid-liquid phase separation, coacervation, and the formation of biomolecular condensates.
Published: 2024

4. On Kernel's Safety in the Spectre Era (Extended Version)

Author: Davoli, Davide, Avanzini, Martin, and Rezk, Tamara
Subjects: Computer Science - Cryptography and Security
Abstract: The efficacy of address space layout randomization has been formally demonstrated in a shared-memory model by Abadi et al., contingent on specific assumptions about victim programs. However, modern operating systems, implementing layout randomization in the kernel, diverge from these assumptions and operate on a separate memory model with communication through system calls. In this work, we relax Abadi et al.'s language assumptions while demonstrating that layout randomization offers a comparable safety guarantee in a system with memory separation. However, in practice, speculative execution and side-channels are recognized threats to layout randomization. We show that kernel safety cannot be restored for attackers capable of using side-channels and speculative execution and introduce a new condition, that allows us to formally prove kernel safety in the Spectre era. Our research demonstrates that under this condition, the system remains safe without relying on layout randomization. We also demonstrate that our condition can be sensibly weakened, leading to enforcement mechanisms that can guarantee kernel safety for safe system calls in the Spectre era.
Published: 2024

5. First joint oscillation analysis of Super-Kamiokande atmospheric and T2K accelerator neutrino data

Author: Super-Kamiokande, collaborations, T2K, Abe, S., Abe, K., Akhlaq, N., Akutsu, R., Alarakia-Charles, H., Ali, A., Hakim, Y. I. Alj, Monsalve, S. Alonso, Amanai, S., Andreopoulos, C., Anthony, L. H. V., Antonova, M., Aoki, S., Apte, K. A., Arai, T., Arihara, T., Arimoto, S., Asada, Y., Asaka, R., Ashida, Y., Atkin, E. T., Babu, N., Barbi, M., Barker, G. J., Barr, G., Barrow, D., Bates, P., Batkiewicz-Kwasniak, M., Beauchêne, A., Berardi, V., Berns, L., Bhadra, S., Bhuiyan, N., Bian, J., Blanchet, A., Blondel, A., Bodur, B., Bolognesi, S., Bordoni, S., Boyd, S. B., Bravar, A., Bronner, C., Bubak, A., Avanzini, M. Buizza, Burton, G. T., Caballero, J. A., Calabria, N. F., Cao, S., Carabadjac, D., Carter, A. J., Cartwright, S. L., Casado, M. P., Catanesi, M. G., Cervera, A., Chakrani, J., Chalumeau, A., Chen, S., Cherdack, D., Choi, K., Chong, P. S., Chvirova, A., Cicerchia, M., Coleman, J., Collazuol, G., Cook, L., Cormier, F., Cudd, A., Dalmazzone, C., Daret, T., Dasgupta, P., Davis, C., Davydov, Yu. I., De Roeck, A., De Rosa, G., Dealtry, T., Delogu, C. C., Densham, C., Dergacheva, A., Dharmapal, R., Di Lodovico, F., Lopez, G. Diaz, Dolan, S., Douqa, D., Doyle, T. A., Drapier, O., Duffy, K. E., Dumarchez, J., Dunne, P., Dygnarowicz, K., D'ago, D., Edwards, R., Eguchi, A., Elias, J., Emery-Schrenk, S., Erofeev, G., Ershova, A., Eurin, G., Fannon, J. E. P., Fedorova, D., Fedotov, S., Feltre, M., Feng, J., Feng, L., Ferlewicz, D., Fernandez, P., Finch, A. J., Aguirre, G. A. Fiorentini, Fiorillo, G., Fitton, M. D., Patiño, J. M. Franco, Friend, M., Fujii, Y., Fujisawa, C., Fujita, S., Fukuda, Y., Furui, Y., Gao, J., Gaur, R., Giampaolo, A., Giannessi, L., Giganti, C., Glagolev, V., Goldsack, A., Gonin, M., Rosa, J. González, Goodman, E. A. G., Gorin, A., Gorshanov, K., Gousy-Leblanc, V., Grassi, M., Griskevich, N. J., Guigue, M., Hadley, D., Haigh, J. T., Han, S., Harada, M., Harris, D. A., Hartz, M., Hasegawa, T., Hassani, S., Hastings, N. C., Hayato, Y., Heitkamp, I., Henaff, D., Hill, J., Hino, Y., Hiraide, K., Hogan, M., Holeczek, J., Holin, A., Holvey, T., Van, N. T. Hong, Honjo, T., Horiuchi, S., Hosokawa, K., Hu, Z., Hu, J., Iacob, F., Ichikawa, A. K., Ieki, K., Ikeda, M., Iovine, N., Ishida, T., Ishino, H., Ishitsuka, M., Ishizuka, T., Ito, H., Itow, Y., Izmaylov, A., Izumiyama, S., Jakkapu, M., Jamieson, B., Jang, M. C., Jang, J. S., Jenkins, S. J., Jesús-Valls, C., Ji, J. Y., Jia, M., Jiang, J., Jonsson, P., Joshi, S., Jung, C. K., Jung, S., Kabirnezhad, M., Kaboth, A. C., Kajita, T., Kakuno, H., Kameda, J., Kanemura, Y., Kaneshima, R., Karpova, S., Kasetti, S. P., Kashiwagi, Y., Kasturi, V. S., Kataoka, Y., Katori, T., Kawamura, Y., Kawaue, M., Kearns, E., Khabibullin, M., Khotjantsev, A., Kikawa, T., Kim, S. B., King, S., Kiseeva, V., Kisiel, J., Kneale, L., Kobayashi, H., Kobayashi, T., Kobayashi, M., Koch, L., Kodama, S., Kolupanova, M., Konaka, A., Kormos, L. L., Koshio, Y., Koto, T., Kowalik, K., Kudenko, Y., Kudo, Y., Kuribayashi, S., Kurjata, R., Kurochka, V., Kutter, T., Kuze, M., Kwon, E., La Commara, M., Labarga, L., Lachat, M., Lachner, K., Lagoda, J., Lakshmi, S. M., LamersJames, M., Langella, A., Laporte, J. -F., Last, D., Latham, N., Laveder, M., Lavitola, L., Lawe, M., Learned, J. G., Lee, Y., Lee, S. H., Silverio, D. Leon, Levorato, S., Lewis, S., Li, X., Li, W., Lin, C., Litchfield, R. P., Liu, S. L., Liu, Y. M., Long, K. R., Longhin, A., Moreno, A. Lopez, Lu, X., Ludovici, L., Lux, T., Machado, L. N., Maekawa, Y., Magaletti, L., Mahn, K., Mahtani, K. K., Malek, M., Mandal, M., Manly, S., Marino, A. D., Martens, K., Marti, Ll., Martin, D. G. R., Martin, J. F., Martin, D., Martini, M., Maruyama, T., Matsubara, T., Matsumoto, R., Mattiazzi, M., Matveev, V., Mauger, C., Mavrokoridis, K., Mazzucato, E., McCauley, N., McElwee, J. M., McFarland, K. S., McGrew, C., McKean, J., Mefodiev, A., Megias, G. D., Mehta, P., Mellet, L., Menjo, H., Metelko, C., Mezzetto, M., Migenda, J., Mijakowski, P., Miki, S., Miller, E., Minamino, A., Mine, S., Mineev, O., Mirabito, J., Miura, M., Bueno, L. Molina, Moon, D. H., Mori, M., Moriyama, S., Morrison, P., Muñoz, A., Mueller, Th. A., Munford, D., Munteanu, L., Nagai, Y., Nagai, K., Nakadaira, T., Nakagiri, K., Nakahata, M., Nakajima, Y., Nakamura, A., Nakamura, K., Nakamura, K. D., Nakamura, T., Nakanishi, F., Nakano, Y., Nakaya, T., Nakayama, S., Nakayoshi, K., Naseby, C. E. R., Ngoc, T. V., Nguyen, V. Q., Nguyen, D. T., Nicholson, M., Niewczas, K., Ninomiya, K., Nishijima, K., Nishimori, S., Nishimura, Y., Noguchi, Y., Nosek, T., Nova, F., Novella, P., Nugent, J. C., Odagawa, T., Okazaki, R., Okazawa, H., Okinaga, W., Okumura, K., Okusawa, T., Ommura, Y., Onda, N., Ospina, N., Osu, L., Oyama, Y., O'Flaherty, M., O'Keeffe, H. M., O'Sullivan, L., Périssé, L., Paganini, P., Palladino, V., Paolone, V., Pari, M., Park, R. G., Parlone, J., Pasternak, J., Payne, D., Penn, G. C., de Perio, P., Pershey, D., Pfaff, M., Pickering, L., Pintaudi, G., Pistillo, C., Pointon, B. W., Popov, B., Yrey, A. Portocarrero, Porwit, K., Posiadala-Zezula, M., Prabhu, Y. S., Prasad, H., Pronost, G., Prouse, N. W., Pupilli, F., Quilain, B., Quyen, P. T., Raaf, J. L., Radermacher, T., Radicioni, E., Radics, B., Ramirez, M. A., Ramsden, R. M., Ratoff, P. N., Reh, M., Riccio, C., Richards, B., Rogly, R., Rondio, E., Roth, S., Roy, N., Rubbia, A., Russo, L., Rychter, A., Saenz, W., Sakai, S., Sakashita, K., Samani, S., Santos, A. D., Sato, Y., Sato, K., Schefke, T., Schloesser, C. M., Scholberg, K., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Seo, J. W., Sgalaberna, D., Shaikhiev, A., Shi, W., Shiba, H., Shibayama, R., Shigeta, N., Shima, S., Shimamura, R., Shimizu, K., Shinoki, M., Shiozawa, M., Shiraishi, Y., Shvartsman, A., Skrobova, N., Skwarczynski, K., Smy, M. B., Smyczek, D., Sobczyk, J. T., Sobel, H. W., Soler, F. J. P., Sonoda, Y., Speers, A. J., Spina, R., Stroke, Y., Suslov, I. A., Suvorov, S., Suzuki, S., Suzuki, A., Suzuki, S. Y., Suzuki, Y., Sánchez, F., Tada, T., Tada, M., Tairafune, S., Takagi, Y., Takeda, A., Takemoto, Y., Takeuchi, Y., Takhistov, V., Takifuji, K., Tanaka, H., Tanaka, H. K., Tanigawa, H., Taniuchi, N., Tano, T., Tarrant, A., Tashiro, T., Teklu, A., Terada, K., Tereshchenko, V. V., Thamm, N., Thiesse, M. D., Thompson, L. F., Toki, W., Tomiya, T., Touramanis, C., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Vagins, M. R., Vargas, D., Varghese, M., Vasseur, G., Villa, E., Vinning, W. G. S., Virginet, U., Vladisavljevic, T., Wachala, T., Wakabayashi, D., Wallace, H. T., Walsh, J. G., Walter, C. W., Wan, L., Wang, X., Wang, Y., Wark, D., Wascko, M. O., Watanabe, E., Weber, A., Wendell, R. A., Wester, T., Wilking, M. J., Wilkinson, C., Wilson, S. T., Wilson, J. R., Wood, K., Wret, C., Wu, Y., Xia, J., Xie, Z., Xu, B. D., Xu, Y. -H., Yamamoto, K., Yamamoto, T., Yamauchi, K., Yanagisawa, C., Yang, G., Yang, B. S., Yang, J. Y., Yankelevich, A., Yano, T., Yasutome, K., Yershov, N., Yevarouskaya, U., Yokoyama, M., Yoo, J., Yoshida, T., Yoshida, S., Yoshimoto, Y., Yoshimura, N., Yoshioka, Y., Yu, M., Yu, I., Zaki, R., Zaldivar, B., Zalewska, A., Zalipska, J., Zaremba, K., Zarnecki, G., Zhang, J., Zhang, A. Q., Zhang, B., Zhao, X. Y., Zhong, H., Zhu, T., Ziembicki, M., Zimmerman, E. D., Zito, M., and Zsoldos, S.
Subjects: High Energy Physics - Experiment
Abstract: The Super-Kamiokande and T2K collaborations present a joint measurement of neutrino oscillation parameters from their atmospheric and beam neutrino data. It uses a common interaction model for events overlapping in neutrino energy and correlated detector systematic uncertainties between the two datasets, which are found to be compatible. Using 3244.4 days of atmospheric data and a beam exposure of $19.7(16.3) \times 10^{20}$ protons on target in (anti)neutrino mode, the analysis finds a 1.9$\sigma$ exclusion of CP-conservation (defined as $J_{CP}=0$) and a preference for the normal mass ordering., Comment: 12 pages, 4 figures
Published: 2024

6. On the Hardness of Analyzing Quantum Programs Quantitatively

Author: Avanzini, Martin, Moser, Georg, Péchoux, Romain, and Perdrix, Simon
Subjects: Computer Science - Logic in Computer Science
Abstract: In this paper, we study quantitative properties of quantum programs. Properties of interest include (positive) almost-sure termination, expected runtime or expected cost, that is, for example, the expected number of applications of a given quantum gate, etc. After studying the completeness of these problems in the arithmetical hierarchy over the Clifford+T fragment of quantum mechanics, we express these problems using a variation of a quantum pre-expectation transformer, a weakest precondition based technique that allows to symbolically compute these quantitative properties. Under a smooth restriction-a restriction to polynomials of bounded degree over a real closed field-we show that the quantitative problem, which consists in finding an upper-bound to the pre-expectation, can be decided in time double-exponential in the size of a program, thus providing, despite its great complexity, one of the first decidable results on the analysis and verification of quantum programs. Finally, we sketch how the latter can be transformed into an efficient synthesis method.
Published: 2023

7. Methods and Conversations in (Post)Modern Thermodynamics

Author: Avanzini, Francesco, Bilancioni, Massimo, Cavina, Vasco, Cengio, Sara Dal, Esposito, Massimiliano, Falasco, Gianmaria, Forastiere, Danilo, Freitas, Nahuel, Garilli, Alberto, Harunari, Pedro E., Lecomte, Vivien, Lazarescu, Alexandre, Srinivas, Shesha G. Marehalli, Moslonka, Charles, Neri, Izaak, Penocchio, Emanuele, Piñeros, William D., Polettini, Matteo, Raghu, Adarsh, Raux, Paul, Sekimoto, Ken, and Soret, Ariane
Subjects: Condensed Matter - Statistical Mechanics
Abstract: Lecture notes after the doctoral school (Post)Modern Thermodynamics held at the University of Luxembourg, December 2022, 5-7, covering and advancing continuous-time Markov chains, network theory, stochastic thermodynamics, large deviations, deterministic and stochastic chemical reaction networks, metastability, martingales, quantum thermodynamics, and foundational issues., Comment: Submission to SciPost
Published: 2023
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8. Characterizing the Conditions for Indefinite Growth in Open Chemical Reaction Networks

Author: Srinivas, Shesha Gopal Marehalli, Avanzini, Francesco, and Esposito, Massimiliano
Subjects: Quantitative Biology - Molecular Networks, Condensed Matter - Statistical Mechanics
Abstract: The thermodynamic and dynamical conditions necessary to observe indefinite growth in homogeneous open chemical reaction networks (CRNs) satisfying mass action kinetics were presented in Srinivas et al. (2023): Unimolecular CRNs can only accumulate equilibrium concentrations of species while multimolecular CRNs are needed to produce indefinite growth with nonequilibrium concentrations. Within multimolecular CRNs, pseudo-unimolecular CRNs produce nonequilibrium concentrations with zero efficiencies. Nonequilibrium growth with finite efficiencies requires dynamically nonlinear CRNs. In this paper, we provide a detailed analysis supporting these results. Mathematical proofs are provided for growth in unimolecular and pseudo-unimolecular CRNs. For multimolecular CRNs, four models displaying very distinctive topological properties are extensively studied, both numerically and partly analytically.
Published: 2023

9. Thermodynamics of Growth in Open Chemical Reaction Networks

Author: Srinivas, Shesha Gopal Marehalli, Avanzini, Francesco, and Esposito, Massimiliano
Subjects: Quantitative Biology - Molecular Networks, Condensed Matter - Statistical Mechanics
Abstract: We identify the thermodynamic conditions necessary to observe indefinite growth in homogeneous open chemical reaction networks (CRNs) satisfying mass action kinetics. We also characterize the thermodynamic efficiency of growth by considering the fraction of the chemical work supplied from the surroundings that is converted into CRN free energy. We find that indefinite growth cannot arise in CRNs chemostatted by fixing the concentration of some species at constant values, or in continuous-flow stirred tank reactors. Indefinite growth requires a constant net influx from the surroundings of at least one species. In this case, unimolecular CRNs always generate equilibrium linear growth, i.e., a continuous linear accumulation of species with equilibrium concentrations and efficiency one. Multimolecular CRNs are necessary to generate nonequilibrium growth, i.e., the continuous accumulation of species with nonequilibrium concentrations. Pseudo-unimolecular CRNs - a subclass of multimolecular CRNs - always generate asymptotic linear growth with zero efficiency. Our findings demonstrate the importance of the CRN topology and the chemostatting procedure in determining the dynamics and thermodynamics of growth.
Published: 2023

10. Ecological transition for the gas mixtures of the MRPC cosmic ray telescopes of the EEE Project

Author: Ripoli, C., Abbrescia, M., Avanzini, C., Baldini, L., Ferroli, R. Baldini, Batignani, G., Battaglieri, M., Boi, S., Bossini, E., Carnesecchi, F., Cavazza, D., Cicalò, C., Cifarelli, L., Coccetti, F., Coccia, E., Corvaglia, A., De Gruttola, D., De Pasquale, S., Galante, L., Garbini, M., Gnesi, I., Gramstad, E., Grazzi, S., Håland, E. S., Hatzifotiadou, D., La Rocca, P., Liu, Z., Lombardo, L., Mandaglio, G., Margotti, A., Maron, G., Mazziotta, M. N., Mulliri, A., Nania, R., Noferini, F., Nozzoli, F., Ould-Saada, F., Palmonari, F., Panareo, M., Panetta, M. P., Paoletti, R., Parvis, M., Pellegrino, C., Perasso, L., Pinazza, O., Pinto, C., Pisano, S., Riggi, F., Righini, G., Rizzi, M., Sartorelli, G., Scapparone, E., Schioppa, M., Scioli, G., Scribano, A., Selvi, M., Taiuti, M., Terreni, G., Trifirò, A., Trimarchi, M., Vistoli, C., Votano, L., Williams, M. C. S., Zichichil, A., and Zuyeuskiv, R.
Subjects: High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract: The Extreme Energy Events (EEE) Collaboration is fully involved in an ecological transition. The use of the standard gas mixture, \ce{C_{2}H_{2}F_{4}}+ \ce{SF_{6}}, has stopped in favor of an alternative green mixture based on \ce{C_{3}H_{2}F_{4}} with the addition of He or \ce{CO_{2}}. The choise of these new mixtures is motivated by the significant lower Global Warming Potential (GWP) to reduce the emission of gases potentially contributing to the greenhouse effect. The EEE experiment consists of 61 muon telescopes based on Multigap Resistive Plate Chambers (MRPCs), each telescope composed of 3 chambers filled with gas. Several EEE detectors are today completely fluxed with the new ecological mixture. This contribution will report recent results about the telescope performance obtained from studies with the eco-friendly alternative mixture carried out in the last years.
Published: 2023

11. The role of de-excitation in the final-state interactions of protons in neutrino-nucleus interactions

Author: Ershova, Anna, Niewczas, Kajetan, Bolognesi, Sara, Letourneau, Alain, David, Jean-Christophe, Rodríguez-Sánchez, José Luís, Sobczyk, Jan, Blanchet, Adrien, Avanzini, Margherita Buizza, Chakrani, Jaafar, Cugnon, Joseph, Dolan, Stephen, Giganti, Claudio, Hassani, Samira, Hirtz, Jason, Joshi, Shivam, Juszczak, Cezary, Munteanu, Laura, Sgalaberna, Davide, and Yevarouskaya, Uladzislava
Subjects: High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract: Present and next generation of long-baseline accelerator experiments are bringing the measurement of neutrino oscillations into the precision era with ever-increasing statistics. One of the most challenging aspects of achieving such measurements is developing relevant systematic uncertainties in the modeling of nuclear effects in neutrino-nucleus interactions. To address this problem, state-of-the-art detectors are being developed to extract detailed information about all particles produced in neutrino interactions. To fully profit from these experimental advancements, it is essential to have reliable models of propagation of the outgoing hadrons through nuclear matter able to predict how the energy is distributed between all the final-state observed particles. In this article, we investigate the role of nuclear de-excitation in neutrino-nucleus scattering using two Monte Carlo cascade models: NuWro and INCL coupled with the de-excitation code ABLA. The ablation model ABLA is used here for the first time to model de-excitation in neutrino interactions. As input to ABLA, we develop a consistent simulation of nuclear excitation energy tuned to electron-scattering data. The paper includes the characterization of the leading proton kinematics and of the nuclear cluster production during cascade and de-excitation. The observability of nuclear clusters as vertex activity and their role in a precise neutrino energy reconstruction is quantified., Comment: 14 pages, 13 figures
Published: 2023

12. Measurements of the $\nu_{\mu}$ and $\bar{\nu}_{\mu}$-induced Coherent Charged Pion Production Cross Sections on $^{12}C$ by the T2K experiment

Author: Abe, K., Akhlaq, N., Akutsu, R., Ali, A., Monsalve, S. Alonso, Alt, C., Andreopoulos, C., Antonova, M., Aoki, S., Arihara, T., Asada, Y., Ashida, Y., Atkin, E. T., Barbi, M., Barker, G. J., Barr, G., Barrow, D., Batkiewicz-Kwasniak, M., Berardi, V., Berns, L., Bhadra, S., Blanchet, A., Blondel, A., Bolognesi, S., Bonus, T., Bordoni, S., Boyd, S. B., Bravar, A., Bronner, C., Bron, S., Bubak, A., Avanzini, M. Buizza, Caballero, J. A., Calabria, N. F., Cao, S., Carabadjac, D., Carter, A. J., Cartwright, S. L., Casado, M. P., Catanesi, M. G., Cervera, A., Chakrani, J., Cherdack, D., Chong, P. S., Christodoulou, G., Chvirova, A., Cicerchia, M., Coleman, J., Collazuol, G., Cook, L., Cudd, A., Dalmazzone, C., Daret, T., Davydov, Yu. I., De Roeck, A., De Rosa, G., Dealtry, T., Delogu, C. C., Densham, C., Dergacheva, A., Di Lodovico, F., Dolan, S., Douqa, D., Doyle, T. A., Drapier, O., Dumarchez, J., Dunne, P., Dygnarowicz, K., Eguchi, A., Emery-Schrenk, S., Erofeev, G., Ershova, A., Eurin, G., Fedorova, D., Fedotov, S., Feltre, M., Finch, A. J., Aguirre, G. A. Fiorentini, Fiorillo, G., Fitton, M. D., Patiño, J. M. Franco, Friend, M., Fujii, Y., Fukuda, Y., Furui, Y., Giannessi, L., Giganti, C., Glagolev, V., Gonin, M., Rosa, J. González, Goodman, E. A. G., Gorin, A., Grassi, M., Guigue, M., Hadley, D. R., Haigh, J. T., Hamacher-Baumann, P., Harris, D. A., Hartz, M., Hasegawa, T., Hassani, S., Hastings, N. C., Hayato, Y., Henaff, D., Hogan, M., Holeczek, J., Holin, A., Holvey, T., Van, N. T. Hong, Honjo, T., Ichikawa, A. K., Ikeda, M., Ishida, T., Ishitsuka, M., Israel, H. T., Izmaylov, A., Jakkapu, M., Jamieson, B., Jenkins, S. J., Jesús-Valls, C., Jiang, J. J., Ji, J. Y., Jonsson, P., Joshi, S., Jung, C. K., Jurj, P. B., Kabirnezhad, M., Kaboth, A. C., Kajita, T., Kakuno, H., Kameda, J., Kasetti, S. P., Kataoka, Y., Katori, T., Kawaue, M., Kearns, E., Khabibullin, M., Khotjantsev, A., Kikawa, T., King, S., Kiseeva, V., Kisiel, J., Kobayashi, H., Kobayashi, T., Koch, L., Kodama, S., Konaka, A., Kormos, L. L., Koshio, Y., Koto, T., Kowalik, K., Kudenko, Y., Kudo, Y., Kuribayashi, S., Kurjata, R., Kutter, T., Kuze, M., La Commara, M., Labarga, L., Lachner, K., Lagoda, J., Lakshmi, S. M., James, M. Lamers, Lamoureux, M., Langella, A., Laporte, J. -F., Last, D., Latham, N., Laveder, M., Lavitola, L., Lawe, M., Lee, Y., Lin, C., Lin, S. -K., Litchfield, R. P., Liu, S. L., Li, W., Longhin, A., Long, K. R., Moreno, A. Lopez, Ludovici, L., Lu, X., Lux, T., Machado, L. N., Magaletti, L., Mahn, K., Malek, M., Mandal, M., Manly, S., Marino, A. D., Marti-Magro, L., Martin, D. G. R., Martini, M., Martin, J. F., Maruyama, T., Matsubara, T., Matveev, V., Mauger, C., Mavrokoridis, K., Mazzucato, E., McCauley, N., McElwee, J., McFarland, K. S., McGrew, C., McKean, J., Mefodiev, A., Megias, G. D., Mehta, P., Mellet, L., Metelko, C., Mezzetto, M., Miller, E., Minamino, A., Mineev, O., Mine, S., Miura, M., Bueno, L. Molina, Moriyama, S., Morrison, P., Mueller, Th. A., Munford, D., Munteanu, L., Nagai, K., Nagai, Y., Nakadaira, T., Nakagiri, K., Nakahata, M., Nakajima, Y., Nakamura, A., Nakamura, H., Nakamura, K., Nakamura, K. D., Nakano, Y., Nakayama, S., Nakaya, T., Nakayoshi, K., Naseby, C. E. R., Ngoc, T. V., Nguyen, V. Q., Niewczas, K., Nishimori, S., Nishimura, Y., Nishizaki, K., Nosek, T., Nova, F., Novella, P., Nugent, J. C., O'Keeffe, H. M., O'Sullivan, L., Odagawa, T., Okinaga, W., Okumura, K., Okusawa, T., Ospina, N., Oyama, Y., Palladino, V., Paolone, V., Pari, M., Parlone, J., Pasternak, J., Pavin, M., Payne, D., Penn, G. C., Pershey, D., Pickering, L., Pidcott, C., Pintaudi, G., Pistillo, C., Popov, B., Porwit, K., Posiadala-Zezula, M., Prabhu, Y. S., Pupilli, F., Quilain, B., Radermacher, T., Radicioni, E., Radics, B., Ramírez, M. A., Ratoff, P. N., Reh, M., Riccio, C., Rondio, E., Roth, S., Roy, N., Rubbia, A., Ruggeri, A. C., Ruggles, C. A., Rychter, A., Sakashita, K., Sánchez, F., Schloesser, C. M., Scholberg, K., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Sgalaberna, D., Shaikhiev, A., Shaker, F., Shiozawa, M., Shorrock, W., Shvartsman, A., Skrobova, N., Skwarczynski, K., Smyczek, D., Smy, M., Sobczyk, J. T., Sobel, H., Soler, F. J. P., Sonoda, Y., Speers, A. J., Spina, R., Suslov, I. A., Suvorov, S., Suzuki, A., Suzuki, S. Y., Suzuki, Y., Tada, M., Tairafune, S., Takayasu, S., Takeda, A., Takeuchi, Y., Takifuji, K., Tanaka, H. K., Tani, M., Teklu, A., Tereshchenko, V. V., Thamm, N., Thompson, L. F., Toki, W., Touramanis, C., Towstego, T., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Vagins, M., Vargas, D., Varghese, M., Vasseur, G., Vilela, C., Villa, E., Vinning, W. G. S., Virginet, U., Vladisavljevic, T., Wachala, T., Walsh, J. G., Wang, Y., Wan, L., Wark, D., Wascko, M. O., Weber, A., Wendell, R., Wilking, M. J., Wilkinson, C., Wilson, J. R., Wood, K., Wret, C., Xia, J., Xu, Y. -h., Yamamoto, K., Yamamoto, T., Yanagisawa, C., Yang, G., Yano, T., Yasutome, K., Yershov, N., Yevarouskaya, U., Yokoyama, M., Yoshimoto, Y., Yoshimura, N., Yu, M., Zaki, R., Zalewska, A., Zalipska, J., Zaremba, K., Zarnecki, G., Zhao, X., Zhu, T., Ziembicki, M., Zimmerman, E. D., Zito, M., and Zsoldos, S.
Subjects: High Energy Physics - Experiment
Abstract: We report an updated measurement of the $\nu_{\mu}$-induced, and the first measurement of the $\bar{\nu}_{\mu}$-induced coherent charged pion production cross section on $^{12}C$ nuclei in the T2K experiment. This is measured in a restricted region of the final-state phase space for which $p_{\mu,\pi} > 0.2$ GeV, $\cos(\theta_{\mu}) > 0.8$ and $\cos(\theta_{\pi}) > 0.6$, and at a mean (anti)neutrino energy of 0.85 GeV using the T2K near detector. The measured $\nu_{\mu}$ CC coherent pion production flux-averaged cross section on $^{12}C$ is $(2.98 \pm 0.37 (stat.) \pm 0.31 (syst.) \substack{ +0.49 \\ -0.00 } \mathrm{ (Q^2\,model)}) \times 10^{-40}~\mathrm{cm}^{2}$. The new measurement of the $\bar{\nu}_{\mu}$-induced cross section on $^{12}{C}$ is $(3.05 \pm 0.71 (stat.) \pm 0.39 (syst.) \substack{ +0.74 \\ -0.00 } \mathrm{(Q^2\,model)}) \times 10^{-40}~\mathrm{cm}^{2}$. The results are compatible with both the NEUT 5.4.0 Berger-Sehgal (2009) and GENIE 2.8.0 Rein-Sehgal (2007) model predictions.
Published: 2023

13. Parametrized uncertainties in the spectral function model of neutrino charged-current quasielastic interactions for oscillation analyses

Author: Chakrani, J., Dolan, S., Avanzini, M. Buizza, Ershova, A., Koch, L., McFarland, K., Megias, G. D., Munteanu, L., Pickering, L., Skwarczynski, K., Nguyen, V. Q., and Wret, C.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: A substantial fraction of systematic uncertainties in neutrino oscillation experiments stem from the lack of precision in modeling the nuclear target in neutrino-nucleus interactions. Whilst this has driven significant progress in the development of improved nuclear models for neutrino scattering, it is crucial that the models used in neutrino data analyses be accompanied by parameters and associated uncertainties that allow the coverage of plausible nuclear physics. Based on constraints from electron scattering data, we develop such a set of parameters, which can be applied to nuclear shell models, and test their application to the Benhar et al spectral function model. The parametrization is validated through a series of maximum likelihood fits to cross-section measurements made by the T2K and MINERvA experiments, which also permit an exploration of the power of near-detector data to provide constraints on the parameters in neutrino oscillation analyses., Comment: 26 pages, 23 figures
Published: 2023

14. Dissipation in Hydrodynamics from Micro- to Macroscale: Wisdom from Boltzmann and Stochastic Thermodynamics

Author: Forastiere, Danilo, Avanzini, Francesco, and Esposito, Massimiliano
Subjects: Condensed Matter - Statistical Mechanics, Physics - Fluid Dynamics
Abstract: We show that macroscopic irreversible thermodynamics for viscous fluids can be derived from exact information-theoretic thermodynamic identities valid at the microscale. Entropy production, in particular, is a measure of the loss of many-particle correlations in the same way in which it measures the loss of system-reservoirs correlations in stochastic thermodynamics (ST). More specifically, we first show that boundary conditions at the macroscopic level define a natural decomposition of the entropy production rate (EPR) in terms of thermodynamic forces multiplying their conjugate currents, as well as a change in suitable nonequilibrium potential that acts as a Lyapunov function in the absence of forces. Moving to the microscale, we identify the exact identities at the origin of these dissipative contributions for isolated Hamiltonian systems. We then show that the molecular chaos hypothesis, which gives rise to the Boltzmann equation at the mesoscale, leads to a positive rate of loss of many-particle correlations, which we identify with the Boltzmann EPR. By generalizing the Boltzmann equation to account for boundaries with nonuniform temperature and nonzero velocity, and resorting to the Chapman-Enskog expansion, we recover the macroscopic theory we started from. Finally, using a linearized Boltzmann equation we derive ST for dilute particles in a weakly out-of-equilibrium fluid and its corresponding macroscopic thermodynamics. Our work unambiguously demonstrates the information-theoretical origin of thermodynamic notions of entropy and dissipation in macroscale irreversible thermodynamics., Comment: 36 pages, 1 figure
Published: 2023

15. Quality of life after colectomy and ileo-jpouch-anal anastomosis in paediatric patients with ulcerative colitis

Author: Wong, M. C. Y., Rotondi, G., Roso, M., Avanzini, P., Gandullia, P., Arrigo, S., and Mattioli, G.
Published: 2024
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16. Exploring the frontier in robotic pediatric cancer surgery: when to move forward and when to stop

Author: Palo, Federico, Avanzini, Stefano, Barretta, Ida, Monti, Martina, Torre, Michele, Conte, Massimo, Calevo, Maria Grazia, and Mattioli, Girolamo
Published: 2024
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17. Pediatric nutritional surgery and its implications: results from a unicentric retrospective analysis

Author: Mattioli, Girolamo, Cipriani, Maria Stella, Barone, Giulia, Palo, Federico, Arrigo, Serena, Gandullia, Paolo, Avanzini, Stefano, and Wong, Michela Cing Yu
Published: 2024
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18. Potential application of mesenchymal stromal cells as a new therapeutic approach in acute respiratory distress syndrome and pulmonary fibrosis

Author: Gazzaniga, Giulia, Voltini, Marta, Carletti, Alessandro, Lenta, Elisa, Meloni, Federica, Briganti, Domenica Federica, Avanzini, Maria Antonietta, Comoli, Patrizia, and Belliato, Mirko
Published: 2024
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19. Exosomal-miRNas expression and growth factors released by mononuclear cells of CLAD patients in response to extracorporeal photopheresis

Author: Bozzini, Sara, Bozza, Eleonora, Bagnera, Cecilia, Del Fante, Claudia, Barone, Eugenio, De Vitis, Simona, De Amici, Mara, Testa, Giorgia, Croce, Stefania, Valsecchi, Chiara, Avanzini, Maria A, Cacciatore, Rosalia, Mortellaro, Cristina, Viarengo, Gianluca, Perotti, Cesare, and Meloni, Federica
Published: 2024
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20. Mechanical and microstructural characterization of Ti6Al4V lattice structures with and without solid shell manufactured via electron beam powder bed fusion

Author: Cantaboni, Francesco, Battini, Davide, Hauber, Keren Z., Ginestra, Paola S., Tocci, Marialaura, Avanzini, Andrea, Ceretti, Elisabetta, and Pola, Annalisa
Published: 2024
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21. Updated T2K measurements of muon neutrino and antineutrino disappearance using 3.6 $\times$ 10$^{21}$ protons on target

Author: Abe, K., Akhlaq, N., Akutsu, R., Alarakia-Charles, H., Ali, A., Hakim, Y. I. Alj, Monsalve, S. Alonso, Alt, C., Andreopoulos, C., Antonova, M., Aoki, S., Arihara, T., Asada, Y., Ashida, Y., Atkin, E. T., Barbi, M., Barker, G. J., Barr, G., Barrow, D., Batkiewicz-Kwasniak, M., Bench, F., Berardi, V., Berns, L., Bhadra, S., Blanchet, A., Blondel, A., Bolognesi, S., Bonus, T., Bordoni, S., Boyd, S. B., Bravar, A., Bronner, C., Bron, S., Bubak, A., Avanzini, M. Buizza, Caballero, J. A., Calabria, N. F., Cao, S., Carabadjac, D., Carter, A. J., Cartwright, S. L., Casado, M. P., Catanesi, M. G., Cervera, A., Chakrani, J., Cherdack, D., Chong, P. S., Christodoulou, G., Chvirova, A., Cicerchia, M., Coleman, J., Collazuol, G., Cook, L., Cudd, A., Dalmazzone, C., Daret, T., Dasgupta, P., Davydov, Yu. I., De Roeck, A., De Rosa, G., Dealtry, T., Delogu, C. C., Densham, C., Dergacheva, A., Di Lodovico, F., Dolan, S., Douqa, D., Doyle, T. A., Drapier, O., Dumarchez, J., Dunne, P., Dygnarowicz, K., Eguchi, A., Emery-Schrenk, S., Erofeev, G., Ershova, A., Eurin, G., Fedorova, D., Fedotov, S., Feltre, M., Finch, A. J., Aguirre, G. A. Fiorentini, Fiorillo, G., Fitton, M. D., Patiño, J. M. Franco, Friend, M., Fujii, Y., Fukuda, Y., Furui, Y., Fusshoeller, K., Giannessi, L., Giganti, C., Glagolev, V., Gonin, M., Rosa, J. González, Goodman, E. A. G., Gorin, A., Grassi, M., Guigue, M., Hadley, D. R., Haigh, J. T., Hamacher-Baumann, P., Harris, D. A., Hartz, M., Hasegawa, T., Hassani, S., Hastings, N. C., Hayato, Y., Henaff, D., Hiramoto, A., Hogan, M., Holeczek, J., Holin, A., Holvey, T., Van, N. T. Hong, Honjo, T., Iacob, F., Ichikawa, A. K., Ikeda, M., Ishida, T., Ishitsuka, M., Israel, H. T., Iwamoto, K., Izmaylov, A., Izumi, N., Jakkapu, M., Jamieson, B., Jenkins, S. J., Jesús-Valls, C., Jiang, J. J., Ji, J. Y., Jonsson, P., Joshi, S., Jung, C. K., Jurj, P. B., Kabirnezhad, M., Kaboth, A. C., Kajita, T., Kakuno, H., Kameda, J., Kasetti, S. P., Kataoka, Y., Katayama, Y., Katori, T., Kawaue, M., Kearns, E., Khabibullin, M., Khotjantsev, A., Kikawa, T., Kikutani, H., King, S., Kiseeva, V., Kisiel, J., Kobata, T., Kobayashi, H., Kobayashi, T., Koch, L., Kodama, S., Konaka, A., Kormos, L. L., Koshio, Y., Kostin, A., Koto, T., Kowalik, K., Kudenko, Y., Kudo, Y., Kuribayashi, S., Kurjata, R., Kutter, T., Kuze, M., La Commara, M., Labarga, L., Lachner, K., Lagoda, J., Lakshmi, S. M., James, M. Lamers, Lamoureux, M., Langella, A., Laporte, J. -F., Last, D., Latham, N., Laveder, M., Lavitola, L., Lawe, M., Lee, Y., Lin, C., Lin, S. -K., Litchfield, R. P., Liu, S. L., Li, W., Longhin, A., Long, K. R., Moreno, A. Lopez, Ludovici, L., Lu, X., Lux, T., Machado, L. N., Magaletti, L., Mahn, K., Malek, M., Mandal, M., Manly, S., Marino, A. D., Marti-Magro, L., Martin, D. G. R., Martini, M., Martin, J. F., Maruyama, T., Matsubara, T., Matveev, V., Mauger, C., Mavrokoridis, K., Mazzucato, E., McCauley, N., McElwee, J., McFarland, K. S., McGrew, C., McKean, J., Mefodiev, A., Megias, G. D., Mehta, P., Mellet, L., Metelko, C., Mezzetto, M., Miller, E., Minamino, A., Mineev, O., Mine, S., Miura, M., Bueno, L. Molina, Moriyama, S., Morrison, P., Mueller, Th. A., Munford, D., Munteanu, L., Nagai, K., Nagai, Y., Nakadaira, T., Nakagiri, K., Nakahata, M., Nakajima, Y., Nakamura, A., Nakamura, H., Nakamura, K., Nakamura, K. D., Nakano, Y., Nakayama, S., Nakaya, T., Nakayoshi, K., Naseby, C. E. R., Ngoc, T. V., Nguyen, V. Q., Niewczas, K., Nishimori, S., Nishimura, Y., Nishizaki, K., Nosek, T., Nova, F., Novella, P., Nugent, J. C., O'Keeffe, H. M., O'Sullivan, L., Odagawa, T., Ogawa, T., Okada, R., Okinaga, W., Okumura, K., Okusawa, T., Ospina, N., Osu, L., Owen, R. A., Oyama, Y., Palladino, V., Paolone, V., Pari, M., Parlone, J., Parsa, S., Pasternak, J., Pavin, M., Payne, D., Penn, G. C., Pershey, D., Pickering, L., Pidcott, C., Pintaudi, G., Pistillo, C., Popov, B., Yrey, A. J. Portocarrero, Porwit, K., Posiadala-Zezula, M., Prabhu, Y. S., Pupilli, F., Quilain, B., Radermacher, T., Radicioni, E., Radics, B., Ramírez, M. A., Ratoff, P. N., Reh, M., Riccio, C., Rondio, E., Roth, S., Roy, N., Rubbia, A., Ruggeri, A. C., Ruggles, C. A., Rychter, A., Sakashita, K., Sánchez, F., Santucci, G., Schefke, T., Schloesser, C. M., Scholberg, K., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Sgalaberna, D., Shaikhiev, A., Shaker, F., Shiozawa, M., Shorrock, W., Shvartsman, A., Skrobova, N., Skwarczynski, K., Smyczek, D., Smy, M., Sobczyk, J. T., Sobel, H., Soler, F. J. P., Sonoda, Y., Speers, A. J., Spina, R., Suslov, I. A., Suvorov, S., Suzuki, A., Suzuki, S. Y., Suzuki, Y., Sztuc, A. A., Tada, M., Tairafune, S., Takayasu, S., Takeda, A., Takeuchi, Y., Takifuji, K., Tanaka, H. K., Tanigawa, H., Tanihara, Y., Tani, M., Teklu, A., Tereshchenko, V. V., Teshima, N., Thamm, N., Thompson, L. F., Toki, W., Touramanis, C., Towstego, T., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Vagins, M., Vargas, D., Varghese, M., Vasseur, G., Vilela, C., Villa, E., Vinning, W. G. S., Virginet, U., Vladisavljevic, T., Wachala, T., Wakabayashi, D., Walsh, J. G., Wang, Y., Wan, L., Wark, D., Wascko, M. O., Weber, A., Wendell, R., Wilking, M. J., Wilkinson, C., Wilson, J. R., Wood, K., Wret, C., Xia, J., Xu, Y. -h., Yamamoto, K., Yamamoto, T., Yanagisawa, C., Yang, G., Yano, T., Yasutome, K., Yershov, N., Yevarouskaya, U., Yokoyama, M., Yoshimoto, Y., Yoshimura, N., Yu, M., Zaki, R., Zalewska, A., Zalipska, J., Zaremba, K., Zarnecki, G., Zhao, X., Zhu, T., Ziembicki, M., Zimmerman, E. D., Zito, M., and Zsoldos, S.
Subjects: High Energy Physics - Experiment
Abstract: Muon neutrino and antineutrino disappearance probabilities are identical in the standard three-flavor neutrino oscillation framework, but CPT violation and non-standard interactions can violate this symmetry. In this work we report the measurements of $\sin^{2} \theta_{23}$ and $\Delta m_{32}^2$ independently for neutrinos and antineutrinos. The aforementioned symmetry violation would manifest as an inconsistency in the neutrino and antineutrino oscillation parameters. The analysis discussed here uses a total of 1.97$\times$10$^{21}$ and 1.63$\times$10$^{21}$ protons on target taken with a neutrino and antineutrino beam respectively, and benefits from improved flux and cross-section models, new near detector samples and more than double the data reducing the overall uncertainty of the result. No significant deviation is observed, consistent with the standard neutrino oscillation picture.
Published: 2023

22. Nonideal Reaction-Diffusion Systems: Multiple Routes to Instability

Author: Aslyamov, Timur, Avanzini, Francesco, Fodor, Étienne, and Esposito, Massimiliano
Subjects: Condensed Matter - Statistical Mechanics, Condensed Matter - Soft Condensed Matter
Abstract: We develop a general classification of the nature of the instabilities yielding spatial organization in open nonideal reaction-diffusion systems, based on linear stability analysis. This encompasses dynamics where chemical species diffuse, interact with each other, and undergo chemical reactions driven out of equilibrium by external chemostats. We find analytically that these instabilities can be of two types: instabilities caused by intermolecular energetic interactions (E type), and instabilities caused by multimolecular out-of-equilibrium chemical reactions (R type). Furthermore, we identify a class of chemical reaction networks, containing unimolecular networks but also extending beyond them, that can only undergo E-type instabilities. We illustrate our analytical findings with numerical simulations on two reaction-diffusion models, each displaying one of the two types of instability and generating stable patterns.
Published: 2023
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23. Automated Expected Value Analysis of Recursive Programs

Author: Avanzini, Martin, Moser, Georg, and Schaper, Michael
Subjects: Computer Science - Programming Languages
Abstract: In this work, we study the fully automated inference of expected result values of probabilistic programs in the presence of natural programming constructs such as procedures, local variables and recursion. While crucial, capturing these constructs becomes highly non-trivial. The key contribution is the definition of a term representation, denoted as infer[.], translating a pre-expectation semantics into first-order constraints, susceptible to automation via standard methods. A crucial step is the use of logical variables, inspired by previous work on Hoare logics for recursive programs. Noteworthy, our methodology is not restricted to tail-recursion, which could unarguably be replaced by iteration and wouldn't need additional insights. We have implemented this analysis in our prototype ev-imp. We provide ample experimental evidence of the prototype's algorithmic expressibility., Comment: Accepted at PLDI'23
Published: 2023

24. First measurement of muon neutrino charged-current interactions on hydrocarbon without pions in the final state using multiple detectors with correlated energy spectra at T2K

Author: Abe, K., Akhlaq, N., Akutsu, R., Alarakia-Charles, H., Ali, A., Hakim, Y. I. Alj, Monsalve, S. Alonso, Alt, C., Andreopoulos, C., Antonova, M., Aoki, S., Arihara, T., Asada, Y., Ashida, Y., Atkin, E. T., Barbi, M., Barker, G. J., Barr, G., Barrow, D., Batkiewicz-Kwasniak, M., Bench, F., Berardi, V., Berns, L., Bhadra, S., Blanchet, A., Blondel, A., Bolognesi, S., Bonus, T., Bordoni, S., Boyd, S. B., Bravar, A., Bronner, C., Bron, S., Bubak, A., Avanzini, M. Buizza, Caballero, J. A., Calabria, N. F., Cao, S., Carabadjac, D., Carter, A. J., Cartwright, S. L., Casado, M. P., Catanesi, M. G., Cervera, A., Chakrani, J., Cherdack, D., Chong, P. S., Christodoulou, G., Chvirova, A., Cicerchia, M., Coleman, J., Collazuol, G., Cook, L., Cudd, A., Dalmazzone, C., Daret, T., Dasgupta, P., Davydov, Yu. I., De Roeck, A., De Rosa, G., Dealtry, T., Delogu, C. C., Densham, C., Dergacheva, A., Di Lodovico, F., Dolan, S., Douqa, D., Doyle, T. A., Drapier, O., Dumarchez, J., Dunne, P., Dygnarowicz, K., Eguchi, A., Emery-Schrenk, S., Erofeev, G., Ershova, A., Eurin, G., Fedorova, D., Fedotov, S., Feltre, M., Finch, A. J., Aguirre, G. A. Fiorentini, Fiorillo, G., Fitton, M. D., Patiño, J. M. Franco, Friend, M., Fujii, Y., Fukuda, Y., Furui, Y., Fusshoeller, K., Giannessi, L., Giganti, C., Glagolev, V., Gonin, M., Rosa, J. González, Goodman, E. A. G., Gorin, A., Grassi, M., Guigue, M., Hadley, D. R., Haigh, J. T., Hamacher-Baumann, P., Harris, D. A., Hartz, M., Hasegawa, T., Hassani, S., Hastings, N. C., Hayato, Y., Henaff, D., Hiramoto, A., Hogan, M., Holeczek, J., Holin, A., Holvey, T., Van, N. T. Hong, Honjo, T., Iacob, F., Ichikawa, A. K., Ikeda, M., Ishida, T., Ishitsuka, M., Israel, H. T., Izmaylov, A., Izumi, N., Jakkapu, M., Jamieson, B., Jenkins, S. J., Jesús-Valls, C., Jiang, J. J., Ji, J. Y., Jonsson, P., Joshi, S., Jung, C. K., Jurj, P. B., Kabirnezhad, M., Kaboth, A. C., Kajita, T., Kakuno, H., Kameda, J., Kasetti, S. P., Kataoka, Y., Katori, T., Kawaue, M., Kearns, E., Khabibullin, M., Khotjantsev, A., Kikawa, T., King, S., Kiseeva, V., Kisiel, J., Kobata, T., Kobayashi, H., Kobayashi, T., Koch, L., Kodama, S., Konaka, A., Kormos, L. L., Koshio, Y., Kostin, A., Koto, T., Kowalik, K., Kudenko, Y., Kudo, Y., Kuribayashi, S., Kurjata, R., Kutter, T., Kuze, M., La Commara, M., Labarga, L., Lachner, K., Lagoda, J., Lakshmi, S. M., James, M. Lamers, Lamoureux, M., Langella, A., Laporte, J. -F., Last, D., Latham, N., Laveder, M., Lavitola, L., Lawe, M., Lee, Y., Lin, C., Lin, S. -K., Litchfield, R. P., Liu, S. L., Li, W., Longhin, A., Long, K. R., Moreno, A. Lopez, Ludovici, L., Lu, X., Lux, T., Machado, L. N., Magaletti, L., Mahn, K., Malek, M., Mandal, M., Manly, S., Marino, A. D., Marti-Magro, L., Martin, D. G. R., Martini, M., Martin, J. F., Maruyama, T., Matsubara, T., Matveev, V., Mauger, C., Mavrokoridis, K., Mazzucato, E., McCauley, N., McElwee, J., McFarland, K. S., McGrew, C., McKean, J., Mefodiev, A., Megias, G. D., Mehta, P., Mellet, L., Metelko, C., Mezzetto, M., Miller, E., Minamino, A., Mineev, O., Mine, S., Miura, M., Bueno, L. Molina, Moriyama, S., Morrison, P., Mueller, Th. A., Munford, D., Munteanu, L., Nagai, K., Nagai, Y., Nakadaira, T., Nakagiri, K., Nakahata, M., Nakajima, Y., Nakamura, A., Nakamura, H., Nakamura, K., Nakamura, K. D., Nakano, Y., Nakayama, S., Nakaya, T., Nakayoshi, K., Naseby, C. E. R., Ngoc, T. V., Nguyen, V. Q., Niewczas, K., Nishimori, S., Nishimura, Y., Nishizaki, K., Nosek, T., Nova, F., Novella, P., Nugent, J. C., O'Keeffe, H. M., O'Sullivan, L., Odagawa, T., Ogawa, T., Okinaga, W., Okumura, K., Okusawa, T., Ospina, N., Osu, L., Owen, R. A., Oyama, Y., Palladino, V., Paolone, V., Pari, M., Parlone, J., Parsa, S., Pasternak, J., Pavin, M., Payne, D., Penn, G. C., Pershey, D., Pickering, L., Pidcott, C., Pintaudi, G., Pistillo, C., Popov, B., Yrey, A. J. Portocarrero, Porwit, K., Posiadala-Zezula, M., Prabhu, Y. S., Pupilli, F., Quilain, B., Radermacher, T., Radicioni, E., Radics, B., Ramírez, M. A., Ratoff, P. N., Reh, M., Riccio, C., Rondio, E., Roth, S., Roy, N., Rubbia, A., Ruggeri, A. C., Ruggles, C. A., Rychter, A., Sakashita, K., Sánchez, F., Santucci, G., Schefke, T., Schloesser, C. M., Scholberg, K., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Sgalaberna, D., Shaikhiev, A., Shaker, F., Shiozawa, M., Shorrock, W., Shvartsman, A., Skrobova, N., Skwarczynski, K., Smyczek, D., Smy, M., Sobczyk, J. T., Sobel, H., Soler, F. J. P., Sonoda, Y., Speers, A. J., Spina, R., Suslov, I. A., Suvorov, S., Suzuki, A., Suzuki, S. Y., Suzuki, Y., Sztuc, A. A., Tada, M., Tairafune, S., Takayasu, S., Takeda, A., Takeuchi, Y., Takifuji, K., Tanaka, H. K., Tanigawa, H., Tani, M., Teklu, A., Tereshchenko, V. V., Teshima, N., Thamm, N., Thompson, L. F., Toki, W., Touramanis, C., Towstego, T., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Vagins, M., Vargas, D., Varghese, M., Vasseur, G., Vilela, C., Villa, E., Vinning, W. G. S., Virginet, U., Vladisavljevic, T., Wachala, T., Wakabayashi, D., Walsh, J. G., Wang, Y., Wan, L., Wark, D., Wascko, M. O., Weber, A., Wendell, R., Wilking, M. J., Wilkinson, C., Wilson, J. R., Wood, K., Wret, C., Xia, J., Xu, Y. -h., Yamamoto, K., Yamamoto, T., Yanagisawa, C., Yang, G., Yano, T., Yasutome, K., Yershov, N., Yevarouskaya, U., Yokoyama, M., Yoshimoto, Y., Yoshimura, N., Yu, M., Zaki, R., Zalewska, A., Zalipska, J., Zaremba, K., Zarnecki, G., Zhao, X., Zhu, T., Ziembicki, M., Zimmerman, E. D., Zito, M., and Zsoldos, S.
Subjects: High Energy Physics - Experiment
Abstract: This paper reports the first measurement of muon neutrino charged-current interactions without pions in the final state using multiple detectors with correlated energy spectra at T2K. The data was collected on hydrocarbon targets using the off-axis T2K near detector (ND280) and the on-axis T2K near detector (INGRID) with neutrino energy spectra peaked at 0.6 GeV and 1.1 GeV respectively. The correlated neutrino flux presents an opportunity to reduce the impact of the flux uncertainty and to study the energy dependence of neutrino interactions. The extracted double-differential cross sections are compared to several Monte Carlo neutrino-nucleus interaction event generators showing the agreement between both detectors individually and with the correlated result., Comment: Updated discussion in Sec. V-A; Updated author list
Published: 2023
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25. Nonequilibrium calcium dynamics optimizes the energetic efficiency of mitochondrial metabolism

Author: Voorsluijs, Valérie, Avanzini, Francesco, Falasco, Gianmaria, Esposito, Massimiliano, and Skupin, Alexander
Subjects: Quantitative Biology - Molecular Networks, Condensed Matter - Other Condensed Matter, Condensed Matter - Statistical Mechanics
Abstract: Living organisms continuously harness energy to perform complex functions for their adaptation and survival while part of that energy is dissipated in the form of heat or chemical waste. Determining the energetic cost and the efficiency of specific cellular processes remains a largely open problem. Here, we analyze the efficiency of mitochondrial adenosine triphosphate (ATP) production through the tricarboxylic acid (TCA) cycle and oxidative phosphorylation that generates most of the cellular chemical energy in eukaryotes. The regulation of this pathway by calcium signaling represents a well-characterized example of a regulatory cross-talk that can affect the energetic output of a metabolic pathway, but its concrete energetic impact remains elusive. On the one hand, calcium enhances ATP production by activating key enzymes of the TCA cycle, but on the other hand calcium homeostasis depends on ATP availability. To evaluate how calcium signaling impacts the efficiency of mitochondrial metabolism, we propose a detailed kinetic model describing the calcium-mitochondria cross-talk and we analyze it using a nonequilibrium thermodynamic approach: after identifying the effective reactions driving mitochondrial metabolism out of equilibrium, we quantify the thermodynamic efficiency of the metabolic machinery for different physiological conditions. We find that calcium oscillations increase the efficiency with a maximum close to substrate-limited conditions, suggesting a compensatory effect of calcium signaling on the energetics of mitochondrial metabolism.
Published: 2023

26. Measurements of neutrino oscillation parameters from the T2K experiment using $3.6\times10^{21}$ protons on target

Author: The T2K Collaboration, Abe, K., Akhlaq, N., Akutsu, R., Ali, A., Monsalve, S. Alonso, Alt, C., Andreopoulos, C., Antonova, M., Aoki, S., Arihara, T., Asada, Y., Ashida, Y., Atkin, E. T., Barbi, M., Barker, G. J., Barr, G., Barrow, D., Batkiewicz-Kwasniak, M., Bench, F., Berardi, V., Berns, L., Bhadra, S., Blanchet, A., Blondel, A., Bolognesi, S., Bonus, T., Bordoni, S., Boyd, S. B., Bravar, A., Bronner, C., Bron, S., Bubak, A., Avanzini, M. Buizza, Caballero, J. A., Calabria, N. F., Cao, S., Carabadjac, D., Carter, A. J., Cartwright, S. L., Catanesi, M. G., Cervera, A., Chakrani, J., Cherdack, D., Chong, P. S., Christodoulou, G., Chvirova, A., Cicerchia, M., Coleman, J., Collazuol, G., Cook, L., Cudd, A., Dalmazzone, C., Daret, T., Davydov, Yu. I., De Roeck, A., De Rosa, G., Dealtry, T., Delogu, C. C., Densham, C., Dergacheva, A., Di Lodovico, F., Dolan, S., Douqa, D., Doyle, T. A., Drapier, O., Dumarchez, J., Dunne, P., Dygnarowicz, K., Eguchi, A., Emery-Schrenk, S., Erofeev, G., Ershova, A., Eurin, G., Fedorova, D., Fedotov, S., Feltre, M., Finch, A. J., Aguirre, G. A. Fiorentini, Fiorillo, G., Fitton, M. D., Patiño, J. M. Franco, Friend, M., Fujii, Y., Fukuda, Y., Fusshoeller, K., Giannessi, L., Giganti, C., Glagolev, V., Gonin, M., Rosa, J. González, Goodman, E. A. G., Gorin, A., Grassi, M., Guigue, M., Hadley, D. R., Haigh, J. T., Hamacher-Baumann, P., Harris, D. A., Hartz, M., Hasegawa, T., Hassani, S., Hastings, N. C., Hayato, Y., Henaff, D., Hiramoto, A., Hogan, M., Holeczek, J., Holin, A., Holvey, T., Van, N. T. Hong, Honjo, T., Iacob, F., Ichikawa, A. K., Ikeda, M., Ishida, T., Ishitsuka, M., Israel, H. T., Iwamoto, K., Izmaylov, A., Izumi, N., Jakkapu, M., Jamieson, B., Jenkins, S. J., Jesús-Valls, C., Jiang, J. J., Jonsson, P., Joshi, S., Jung, C. K., Jurj, P. B., Kabirnezhad, M., Kaboth, A. C., Kajita, T., Kakuno, H., Kameda, J., Kasetti, S. P., Kataoka, Y., Katayama, Y., Katori, T., Kawaue, M., Kearns, E., Khabibullin, M., Khotjantsev, A., Kikawa, T., Kikutani, H., King, S., Kiseeva, V., Kisiel, J., Kobata, T., Kobayashi, H., Kobayashi, T., Koch, L., Kodama, S., Konaka, A., Kormos, L. L., Koshio, Y., Kostin, A., Koto, T., Kowalik, K., Kudenko, Y., Kudo, Y., Kuribayashi, S., Kurjata, R., Kutter, T., Kuze, M., La Commara, M., Labarga, L., Lachner, K., Lagoda, J., Lakshmi, S. M., James, M. Lamers, Lamoureux, M., Langella, A., Laporte, J. -F., Last, D., Latham, N., Laveder, M., Lavitola, L., Lawe, M., Lee, Y., Lin, C., Lin, S. -K., Litchfield, R. P., Liu, S. L., Li, W., Longhin, A., Long, K. R., Moreno, A. Lopez, Ludovici, L., Lu, X., Lux, T., Machado, L. N., Magaletti, L., Mahn, K., Malek, M., Mandal, M., Manly, S., Marino, A. D., Marti-Magro, L., Martin, D. G. R., Martini, M., Martin, J. F., Maruyama, T., Matsubara, T., Matveev, V., Mauger, C., Mavrokoridis, K., Mazzucato, E., McCauley, N., McElwee, J., McFarland, K. S., McGrew, C., McKean, J., Mefodiev, A., Megias, G. D., Mehta, P., Mellet, L., Metelko, C., Mezzetto, M., Miller, E., Minamino, A., Mineev, O., Mine, S., Miura, M., Bueno, L. Molina, Moriyama, S., Morrison, P., Mueller, Th. A., Munford, D., Munteanu, L., Nagai, K., Nagai, Y., Nakadaira, T., Nakagiri, K., Nakahata, M., Nakajima, Y., Nakamura, A., Nakamura, H., Nakamura, K., Nakamura, K. D., Nakano, Y., Nakayama, S., Nakaya, T., Nakayoshi, K., Naseby, C. E. R., Ngoc, T. V., Nguyen, V. Q., Niewczas, K., Nishimori, S., Nishimura, Y., Nishizaki, K., Nosek, T., Nova, F., Novella, P., Nugent, J. C., O'Keeffe, H. M., O'Sullivan, L., Odagawa, T., Ogawa, T., Okada, R., Okinaga, W., Okumura, K., Okusawa, T., Ospina, N., Owen, R. A., Oyama, Y., Palladino, V., Paolone, V., Pari, M., Parlone, J., Parsa, S., Pasternak, J., Pavin, M., Payne, D., Penn, G. C., Pershey, D., Pickering, L., Pidcott, C., Pintaudi, G., Pistillo, C., Popov, B., Porwit, K., Posiadala-Zezula, M., Prabhu, Y. S., Pupilli, F., Quilain, B., Radermacher, T., Radicioni, E., Radics, B., Ramírez, M. A., Ratoff, P. N., Reh, M., Riccio, C., Rondio, E., Roth, S., Roy, N., Rubbia, A., Ruggeri, A. C., Ruggles, C. A., Rychter, A., Sakashita, K., Sánchez, F., Santucci, G., Schloesser, C. M., Scholberg, K., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Sgalaberna, D., Shaikhiev, A., Shaker, F., Shaykina, A., Shiozawa, M., Shorrock, W., Shvartsman, A., Skrobova, N., Skwarczynski, K., Smyczek, D., Smy, M., Sobczyk, J. T., Sobel, H., Soler, F. J. P., Sonoda, Y., Speers, A. J., Spina, R., Suslov, I. A., Suvorov, S., Suzuki, A., Suzuki, S. Y., Suzuki, Y., Sztuc, A. A., Tada, M., Tairafune, S., Takayasu, S., Takeda, A., Takeuchi, Y., Takifuji, K., Tanaka, H. K., Tanihara, Y., Tani, M., Teklu, A., Tereshchenko, V. V., Teshima, N., Thamm, N., Thompson, L. F., Toki, W., Touramanis, C., Towstego, T., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Vagins, M., Vargas, D., Varghese, M., Vasseur, G., Vilela, C., Villa, E., Vinning, W. G. S., Virginet, U., Vladisavljevic, T., Wachala, T., Walsh, J. G., Wang, Y., Wan, L., Wark, D., Wascko, M. O., Weber, A., Wendell, R., Wilking, M. J., Wilkinson, C., Wilson, J. R., Wood, K., Wret, C., Xia, J., Xu, Y. -h., Yamamoto, K., Yamamoto, T., Yanagisawa, C., Yang, G., Yano, T., Yasutome, K., Yershov, N., Yevarouskaya, U., Yokoyama, M., Yoshimoto, Y., Yoshimura, N., Yu, M., Zaki, R., Zalewska, A., Zalipska, J., Zaremba, K., Zarnecki, G., Zhao, X., Zhu, T., Ziembicki, M., Zimmerman, E. D., Zito, M., and Zsoldos, S.
Subjects: High Energy Physics - Experiment
Abstract: The T2K experiment presents new measurements of neutrino oscillation parameters using $19.7(16.3)\times10^{20}$ protons on target (POT) in (anti-)neutrino mode at the far detector (FD). Compared to the previous analysis, an additional $4.7\times10^{20}$ POT neutrino data was collected at the FD. Significant improvements were made to the analysis methodology, with the near-detector analysis introducing new selections and using more than double the data. Additionally, this is the first T2K oscillation analysis to use NA61/SHINE data on a replica of the T2K target to tune the neutrino flux model, and the neutrino interaction model was improved to include new nuclear effects and calculations. Frequentist and Bayesian analyses are presented, including results on $\sin^2\theta_{13}$ and the impact of priors on the $\delta_\mathrm{CP}$ measurement. Both analyses prefer the normal mass ordering and upper octant of $\sin^2\theta_{23}$ with a nearly maximally CP-violating phase. Assuming the normal ordering and using the constraint on $\sin^2\theta_{13}$ from reactors, $\sin^2\theta_{23}=0.561^{+0.021}_{-0.032}$ using Feldman--Cousins corrected intervals, and $\Delta{}m^2_{32}=2.494_{-0.058}^{+0.041}\times10^{-3}~\mathrm{eV^2}$ using constant $\Delta\chi^{2}$ intervals. The CP-violating phase is constrained to $\delta_\mathrm{CP}=-1.97_{-0.70}^{+0.97}$ using Feldman--Cousins corrected intervals, and $\delta_\mathrm{CP}=0,\pi$ is excluded at more than 90% confidence level. A Jarlskog invariant of zero is excluded at more than $2\sigma$ credible level using a flat prior in $\delta_\mathrm{CP}$, and just below $2\sigma$ using a flat prior in $\sin\delta_\mathrm{CP}$. When the external constraint on $\sin^2\theta_{13}$ is removed, $\sin^2\theta_{13}=28.0^{+2.8}_{-6.5}\times10^{-3}$, in agreement with measurements from reactor experiments. These results are consistent with previous T2K analyses.
Published: 2023
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27. Deficiency, Kinetic Invertibility, and Catalysis in Stochastic Chemical Reaction Networks

Author: Srinivas, Shesha Gopal Marehalli, Polettini, Matteo, Esposito, Massimiliano, and Avanzini, Francesco
Subjects: Condensed Matter - Statistical Mechanics, Physics - Chemical Physics
Abstract: Stochastic chemical processes are described by the chemical master equation satisfying the law of mass-action. We first ask whether the dual master equation, which has the same steady state as the chemical master equation, but with inverted reaction currents, satisfies the law of mass-action, namely, still describes a chemical process. We prove that the answer depends on the topological property of the underlying chemical reaction network known as deficiency. The answer is yes only for deficiency-zero networks. It is no for all other networks, implying that their steady-state currents cannot be inverted by controlling the kinetic constants of the reactions. Hence, the network deficiency imposes a form of non-invertibility to the chemical dynamics. We then ask whether catalytic chemical networks are deficiency-zero. We prove that the answer is no when they are driven out of equilibrium due to the exchange of some species with the environment.
Published: 2023
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28. Circuit Theory for Chemical Reaction Networks

Author: Avanzini, Francesco, Freitas, Nahuel, and Esposito, Massimiliano
Subjects: Quantitative Biology - Molecular Networks, Condensed Matter - Statistical Mechanics
Abstract: We lay the foundation of a circuit theory for chemical reaction networks. Chemical reactions are grouped into chemical modules solely characterized by their current-concentration characteristic, as electrical devices by their current-voltage (I-V) curve in electronic circuit theory. This, combined with the chemical analog of Kirchhoff's current and voltage laws, provides a powerful tool to predict reaction currents and dissipation across complex chemical networks. The theory can serve to build accurate reduced models of complex networks as well as to design networks performing desired tasks.
Published: 2022
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29. Diagnostic accuracy of upper gastrointestinal series in children with suspected intestinal malrotation

Author: Girolamo, Mattioli, Emanuela, Gallo, Yu, Wong Michela Cing, Anna, Marzoli, Marta, Pongiglione, Grazia, Calevo Maria, Gandullia, Paolo, Arrigo, Serena, Stefano, Avanzini, and Beatrice, Damasio Maria
Published: 2024
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30. Digital Music Learning Resources: From Research to Educational Practice. SpingerBriefs in Education

Author: Marcella Mandanici, Simone Spagnol, Luca Andrea Ludovico, Adriano Baratè, Federico Avanzini, Marcella Mandanici, Simone Spagnol, Luca Andrea Ludovico, Adriano Baratè, and Federico Avanzini
Abstract: This book offers an overview of the complex world of digital materials for music education and of their possible use in the everyday practice of music teachers. It presents a multidimensional taxonomy of digital materials for music education. Through the taxonomy it is possible to derive a clear framework of the whole field and to perform analysis of the state of art. The book shows the use of this flexible and powerful knowledge tool for reviewing the digital materials in the various domains and dimensions. The book provides researchers and designers with an overview of what has already been designed, proposed and tested in the field. It also offers music teachers a wider perspective of the possibilities connected to current technologies in the field of music education, and it suggests possible interrelationships between research and music education practices.
Published: 2023
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31. Bone Marrow Mesenchymal Stem Cells Expanded Inside the Nichoid Micro-Scaffold: a Focus on Anti-Inflammatory Response

Author: Barzaghini, Bianca, Carelli, Stephana, Messa, Letizia, Rey, Federica, Avanzini, Maria Antonietta, Jacchetti, Emanuela, Maghraby, Erika, Berardo, Clarissa, Zuccotti, Gianvincenzo, Raimondi, Manuela Teresa, Cereda, Cristina, Calcaterra, Valeria, and Pelizzo, Gloria
Published: 2023
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32. Potential application of mesenchymal stromal cells as a new therapeutic approach in acute respiratory distress syndrome and pulmonary fibrosis

Author: Giulia Gazzaniga, Marta Voltini, Alessandro Carletti, Elisa Lenta, Federica Meloni, Domenica Federica Briganti, Maria Antonietta Avanzini, Patrizia Comoli, and Mirko Belliato
Subjects: Acute respiratory distress syndrome, ARDS, Pulmonary fibrosis, Mesenchymal stromal cells, COVID-19, Diseases of the respiratory system, RC705-779
Abstract: Abstract While the COVID-19 outbreak and its complications are still under investigation, post-inflammatory pulmonary fibrosis (PF) has already been described as a long-term sequela of acute respiratory distress syndrome (ARDS) secondary to SARS-CoV2 infection. However, therapeutical strategies for patients with ARDS and PF are still limited and do not significantly extend lifespan. So far, lung transplantation remains the only definitive treatment for end-stage PF. Over the last years, numerous preclinical and clinical studies have shown that allogeneic mesenchymal stromal cells (MSCs) might represent a promising therapeutical approach in several lung disorders, and their potential for ARDS treatment and PF prevention has been investigated during the COVID-19 pandemic. From April 2020 to April 2022, we treated six adult patients with moderate COVID-19-related ARDS in a late proliferative stage with up to two same-dose infusions of third-party allogeneic bone marrow-derived MSCs (BM-MSCs), administered intravenously 15 days apart. No major adverse events were registered. Four patients completed the treatment and reached ICU discharge, while two received only one dose of MSCs due to multiorgan dysfunction syndrome (MODS) and subsequent death. All four survivors showed improved gas exchanges (PaO2/FiO2 ratio > 200), contrary to the others. Furthermore, LDH trends after MSCs significantly differed between survivors and the deceased. Although further investigations and shared protocols are still needed, the safety of MSC therapy has been recurrently shown, and its potential in treating ARDS and preventing PF might represent a new therapeutic strategy.
Published: 2024
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33. Exosomal-miRNas expression and growth factors released by mononuclear cells of CLAD patients in response to extracorporeal photopheresis

Author: Sara Bozzini, Eleonora Bozza, Cecilia Bagnera, Claudia Del Fante, Eugenio Barone, Simona De Vitis, Mara De Amici, Giorgia Testa, Stefania Croce, Chiara Valsecchi, Maria A Avanzini, Rosalia Cacciatore, Cristina Mortellaro, Gianluca Viarengo, Cesare Perotti, and Federica Meloni
Subjects: Exosomal-miRNas, Extracorporeal photopheresis, ECP, CLAD, T regulatory cells, Lung transplantation, Medicine
Abstract: Abstract Background CLAD (Chronic Lung Allograft Dysfunction) remains a serious complication following lung transplantation. Some evidence shows that portions of Extracorporeal Photopheresis (ECP)-treated patients improve/stabilize their graft function. In spite of that, data concerning molecular mechanisms are still lacking. Aims of our study were to assess whether ECP effects are mediated by Mononuclear Cells (MNCs) modulation in term of microRNAs (miRNAs) expression and growth factors release. Methods Cells from leukapheresis of 16 CLAD patients, at time 0 and 6-months (10 cycles), were cultured for 48h ± PHA (10 ug/ml) or LPS (2 ug/ml). Expression levels of miR-146a-5p, miR-155-5p, miR-31-5p, miR181a-5p, miR-142-3p, miR-16-5p and miR-23b-5p in MNCs-exosomes were evaluated by qRT-PCR, while ELISA assessed different growth factors levels on culture supernatants. Results Our result showed miR-142-3p down-regulation (p = 0.02) in MNCs of ECP-patients after the 10 cycles and after LPS stimulation (p = 0.005). We also find miR-146a-5p up-regulation in cells after the 10 cycles stimulated with LPS (p = 0.03). Connective tissue growth factor (CTGF) levels significantly decreased in MNCs supernatant (p = 0.04). The effect of ECP is translated into frequency changes of Dendritic Cell (DC) subpopulations and a slight increase in T regulatory cells (Treg) number and a significant decrease in CTGF release. Conclusions ECP might affect regulatory T cell functions, since both miR-142 and miR-146a have been shown to be involved in the regulation of suppressor regulatory T cell functions and DCs. On the other side ECP, possibly by regulating macrophage activation, is able to significantly down modulate CTGF release.
Published: 2024
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34. Scintillator ageing of the T2K near detectors from 2010 to 2021

Author: The T2K Collaboration, Abe, K., Akhlaq, N., Akutsu, R., Ali, A., Alt, C., Andreopoulos, C., Antonova, M., Aoki, S., Arihara, T., Asada, Y., Ashida, Y., Atkin, E. T., Ban, S., Barbi, M., Barker, G. J., Barr, G., Barrow, D., Batkiewicz-Kwasniak, M., Bench, F., Berardi, V., Berns, L., Bhadra, S., Blanchet, A., Blondel, A., Bolognesi, S., Bonus, T., Bordoni, S., Boyd, S. B., Bravar, A., Bronner, C., Bron, S., Bubak, A., Avanzini, M. Buizza, Calabria, N. F., Cao, S., Carter, A. J., Cartwright, S. L., Catanesi, M. G., Cervera, A., Chakrani, J., Cherdack, D., Christodoulou, G., Cicerchia, M., Coleman, J., Collazuol, G., Cook, L., Cudd, A., Davydov, Yu. I., De Roeck, A., De Rosa, G., Dealtry, T., Delogu, C. C., Densham, C., Dergacheva, A., Di Lodovico, F., Dolan, S., Douqa, D., Doyle, T. A., Drapier, O., Duffy, K. E., Dumarchez, J., Dunne, P., Dygnarowicz, K., Eguchi, A., Emery-Schrenk, S., Ershova, A., Fedotov, S., Fernandez, P., Finch, A. J., Aguirre, G. A. Fiorentini, Fiorillo, G., Friend, M., Fujii, Y., Fukuda, Y., Fusshoeller, K., Giganti, C., Glagolev, V., Gonin, M., Goodman, E. A. G., Gorin, A., Grassi, M., Guigue, M., Hadley, D. R., Haigh, J. T., Hamacher-Baumann, P., Harris, D. A., Hartz, M., Hasegawa, T., Hassani, S., Hastings, N. C., Hatzikoutelis, A., Hayato, Y., Hiramoto, A., Hogan, M., Holeczek, J., Holin, A., Holvey, T. J., Van, N. T. Hong, Honjo, T., Iacob, F., Ichikawa, A. K., Ikeda, M., Ishida, T., Ishitsuka, M., Israel, H. T., Iwamoto, K., Izmaylov, A., Izumi, N., Jakkapu, M., Jamieson, B., Jenkins, S. J., Jesús-Valls, C., Jiang, J. J., Jonsson, P., Jung, C. K., Jurj, P. B., Kabirnezhad, M., Kaboth, A. C., Kajita, T., Kakuno, H., Kameda, J., Kasetti, S. P., Kataoka, Y., Katayama, Y., Katori, T., Kawaue, M., Kearns, E., Khabibullin, M., Khotjantsev, A., Kikawa, T., Kikutani, H., King, S., Kisiel, J., Knight, A., Kobata, T., Kobayashi, T., Koch, L., Kogan, G., Konaka, A., Kormos, L. L., Koshio, Y., Kostin, A., Kowalik, K., Kudenko, Y., Kuribayashi, S., Kurjata, R., Kutter, T., Kuze, M., La Commara, M., Labarga, L., Lagoda, J., Lakshmi, S. M., James, M. Lamers, Lamont, I., Lamoureux, M., Last, D., Latham, N., Laveder, M., Lawe, M., Lee, Y., Lin, C., Lindner, T., Lin, S. -K., Litchfield, R. P., Liu, S. L., Longhin, A., Long, K. R., Ludovici, L., Lu, X., Lux, T., Machado, L. N., Magaletti, L., Mahn, K., Malek, M., Mandal, M., Manly, S., Marino, A. D., Marti-Magro, L., Martin, D. G. R., Martini, M., Martin, J. F., Maruyama, T., Matsubara, T., Matveev, V., Mauger, C., Mavrokoridis, K., Mazzucato, E., McCauley, N., McElwee, J., McFarland, K. S., McGrew, C., Mefodiev, A., Megias, G. D., Mellet, L., Metelko, C., Mezzetto, M., Minamino, A., Mineev, O., Mine, S., Miura, M., Bueno, L. Molina, Moriyama, S., Mueller, Th. A., Munford, D., Munteanu, L., Nagai, K., Nagai, Y., Nakadaira, T., Nakagiri, K., Nakahata, M., Nakajima, Y., Nakamura, A., Nakamura, H., Nakamura, K., Nakano, Y., Nakayama, S., Nakaya, T., Nakayoshi, K., Naseby, C. E. R., Ngoc, T. V., Nguyen, V. Q., Niewczas, K., Nishimura, Y., Nishizaki, K., Nova, F., Novella, P., Nugent, J. C., O'Keeffe, H. M., O'Sullivan, L., Odagawa, T., Ogawa, T., Okada, R., Okumura, K., Okusawa, T., Owen, R. A., Oyama, Y., Palladino, V., Paolone, V., Pari, M., Parlone, J., Parsa, S., Pasternak, J., Pavin, M., Payne, D., Penn, G. C., Pershey, D., Pickering, L., Pidcott, C., Pintaudi, G., Pistillo, C., Popov, B., Porwit, K., Posiadala-Zezula, M., Prabhu, Y. S., Quilain, B., Radermacher, T., Radicioni, E., Radics, B., Ratoff, P. N., Reh, M., Riccio, C., Rondio, E., Roth, S., Rubbia, A., Ruggeri, A. C., Ruggles, C. A., Rychter, A., Sakashita, K., Sánchez, F., Santucci, G., Schloesser, C. M., Scholberg, K., Scott, M., Seiya, Y., Sekiguchi, T., Sekiya, H., Sgalaberna, D., Shaikhiev, A., Shaykina, A., Shiozawa, M., Shorrock, W., Shvartsman, A., Skwarczynski, K., Smy, M., Sobczyk, J. T., Sobel, H., Soler, F. J. P., Sonoda, Y., Spina, R., Su, H., Suslov, I. A., Suvorov, S., Suzuki, A., Suzuki, S. Y., Suzuki, Y., Sztuc, A. A., Tada, M., Takayasu, S., Takeda, A., Takeuchi, Y., Tanaka, H. K., Tanihara, Y., Tani, M., Tereshchenko, V. V., Teshima, N., Thamm, N., Thompson, L. F., Toki, W., Touramanis, C., Towstego, T., Tsui, K. M., Tsukamoto, T., Tzanov, M., Uchida, Y., Vacheret, A., Vagins, M., Vargas, D., Vasseur, G., Vilela, C., Vinning, W. G. S., Vladisavljevic, T., Wachala, T., Walsh, J. G., Wang, Y., Wan, L., Wark, D., Wascko, M. O., Weber, A., Wendell, R., Wilking, M. J., Wilkinson, C., Wilson, J. R., Wood, K., Wret, C., Xia, J., Xu, Y. -h., Yamamoto, K., Yanagisawa, C., Yang, G., Yano, T., Yasutome, K., Yershov, N., Yevarouskaya, U., Yokoyama, M., Yoshimoto, Y., Yu, M., Zaki, R., Zalewska, A., Zalipska, J., Zaremba, K., Zarnecki, G., Zhao, X., Zhu, T., Ziembicki, M., Zimmerman, E. D., Zito, M., and Zsoldos, S.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: The T2K experiment widely uses plastic scintillator as a target for neutrino interactions and an active medium for the measurement of charged particles produced in neutrino interactions at its near detector complex. Over 10 years of operation the measured light yield recorded by the scintillator based subsystems has been observed to degrade by 0.9--2.2\% per year. Extrapolation of the degradation rate through to 2040 indicates the recorded light yield should remain above the lower threshold used by the current reconstruction algorithms for all subsystems. This will allow the near detectors to continue contributing to important physics measurements during the T2K-II and Hyper-Kamiokande eras. Additionally, work to disentangle the degradation of the plastic scintillator and wavelength shifting fibres shows that the reduction in light yield can be attributed to the ageing of the plastic scintillator., Comment: 29 pages, 18 figures. Prepared for submission to JINST
Published: 2022

35. SuperFGD prototype time resolution studies

Author: Alekseev, I., Arihara, T., Baranov, V., Bartoszek, L., Bernardi, L., Blondel, A., Boikov, A. V., Buizza-Avanzini, M., Cadoux, F., Capó, J., Cayo, J., Chakrani, J., Chong, P. S., Chvirova, A., Danilov, M., Davydov, Yu. I., Dergacheva, A., Dokania, N., Douqa, D., Drapier, O., Eguchi, A., Favre, Y., Fedorova, D., Fedotov, S., Fujii, Y., Gastaldi, F., Gendotti, A., Glagolev, V., Guillaumat, R., Iwamoto, K., Jakkapu, M., Jesús-Valls, C., Jung, C. K., Kakuno, H., Kasetti, S. P., Khabibullin, M., Khotjantsev, A., Kikutani, H., Kobayashi, T., Kodama, S., Korzenev, A., Kose, U., Kudenko, Y., Kutter, T., Last, D., Li, B., Li, Z., Lin, L. S., Lin, S., Louzir, M., Lux, T., Maret, L., Martynenko, S., Matsubara, T., Mauger, C., McGrew, C., Mefodiev, A., Mineev, O., Nakadaira, T., Nakagiri, K., Nanni, J., Nicola, L., Noah, E., Paolone, V., Parsa, S., Pellegrino, R., Ramirez, M. A., Reh, M., Ricco, C., Rubbia, A., Sakashita, K., Sanchez, F., Sgalaberna, D., Shvartsman, A., Skrobova, N., Suslov, I. A., Suvorov, S., Svirida, D., Teklu, A., Tereshchenko, V. V., Tzanov, M., Vasilyev, I. I., Wood, K., Yang, G., Yershov, N., Yokoyama, M., Yoshimoto, Y., Zhao, X., Zilberman, P., and Zimmerman, E. D.
Subjects: Physics - Instrumentation and Detectors
Abstract: The SuperFGD will be a part of the ND280 near detector of the T2K and Hyper Kamiokande projects, that will help to reduce systematic uncertainties related with neutrino flux and cross-section modeling. The upgraded ND280 will be able to perform a full exclusive reconstruction of the final state from neutrino-nucleus interactions, including measurements of low momentum protons, pions and, for the first time, event-by event measurements of neutron kinematics. The time resolution defines the neutron energy resolution. We present the results of time resolution measurements made with the SuperFGD prototype that consists of 9216 plastic scintillator cubes (cube size is 1 cm$^3$) readout with 1728 wavelength-shifting fibers going along three orthogonal directions. We use data from the muon beam exposure at CERN. The time resolution of 0.97 ns was obtained for one readout channel after implementing the time calibration with a correction for the time-walk effect. The time resolution improves with energy deposited in a scintillator cube. Averaging two readout channels for one scintillator cube improves the time resolution to 0.68 ns which means that signals in different channels are not synchronous. Therefore the contribution from the time recording step of 2.5 ns is averaged as well. Averaging time values from N channels improves the time resolution by $\sim 1/\sqrt{N}$. Therefore a very good time resolution should be achievable for neutrons since neutron recoils hit typically several scintillator cubes and in addition produce larger amplitudes than muons. Measurements performed with a laser and a wide-bandwidth oscilloscope demonstrated that the time resolution obtained with the muon beam is not far from its expected limit. The intrinsic time resolution of one channel is 0.67 ns for signals of 56 photo-electron typical for minimum ionizing particles., Comment: 12 pages, 9 figures. Revised text, results unchanged
Published: 2022
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36. Measurements of neutrino oscillation parameters from the T2K experiment using 3.6×1021 protons on target

Author: Abe, K, Akhlaq, N, Akutsu, R, Ali, A, Alonso Monsalve, S, Alt, C, Andreopoulos, C, Antonova, M, Aoki, S, Arihara, T, Asada, Y, Ashida, Y, Atkin, ET, Barbi, M, Barker, GJ, Barr, G, Barrow, D, Batkiewicz-Kwasniak, M, Bench, F, Berardi, V, Berns, L, Bhadra, S, Blanchet, A, Blondel, A, Bolognesi, S, Bonus, T, Bordoni, S, Boyd, SB, Bravar, A, Bronner, C, Bron, S, Bubak, A, Buizza Avanzini, M, Caballero, JA, Calabria, NF, Cao, S, Carabadjac, D, Carter, AJ, Cartwright, SL, Catanesi, MG, Cervera, A, Chakrani, J, Cherdack, D, Chong, PS, Christodoulou, G, Chvirova, A, Cicerchia, M, Coleman, J, Collazuol, G, Cook, L, Cudd, A, Dalmazzone, C, Daret, T, Davydov, Yu I, De Roeck, A, De Rosa, G, Dealtry, T, Delogu, CC, Densham, C, Dergacheva, A, Di Lodovico, F, Dolan, S, Douqa, D, Doyle, TA, Drapier, O, Dumarchez, J, Dunne, P, Dygnarowicz, K, Eguchi, A, Emery-Schrenk, S, Erofeev, G, Ershova, A, Eurin, G, Fedorova, D, Fedotov, S, Feltre, M, Finch, AJ, Fiorentini Aguirre, GA, Fiorillo, G, Fitton, MD, Franco Patiño, JM, Friend, M, Fujii, Y, Fukuda, Y, Fusshoeller, K, Giannessi, L, Giganti, C, Glagolev, V, Gonin, M, González Rosa, J, Goodman, EAG, Gorin, A, Grassi, M, Guigue, M, Hadley, DR, Haigh, JT, Hamacher-Baumann, P, Harris, DA, Hartz, M, and Hasegawa, T
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, T2K Collaboration, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics, Nuclear & Particles Physics, Astronomical sciences, Atomic, molecular and optical physics, Particle and high energy physics
Abstract: The T2K experiment presents new measurements of neutrino oscillation parameters using 19.7(16.3)×1020 protons on target (POT) in (anti-)neutrino mode at the far detector (FD). Compared to the previous analysis, an additional 4.7×1020 POT neutrino data was collected at the FD. Significant improvements were made to the analysis methodology, with the near-detector analysis introducing new selections and using more than double the data. Additionally, this is the first T2K oscillation analysis to use NA61/SHINE data on a replica of the T2K target to tune the neutrino flux model, and the neutrino interaction model was improved to include new nuclear effects and calculations. Frequentist and Bayesian analyses are presented, including results on sin2θ13 and the impact of priors on the δCP measurement. Both analyses prefer the normal mass ordering and upper octant of sin2θ23 with a nearly maximally CP-violating phase. Assuming the normal ordering and using the constraint on sin2θ13 from reactors, sin2θ23=0.561-0.032+0.021 using Feldman-Cousins corrected intervals, and Δm322=2.494-0.058+0.041×10-3eV2 using constant Δχ2 intervals. The CP-violating phase is constrained to δCP=-1.97-0.70+0.97 using Feldman-Cousins corrected intervals, and δCP=0,π is excluded at more than 90% confidence level. A Jarlskog invariant of zero is excluded at more than 2σ credible level using a flat prior in δCP, and just below 2σ using a flat prior in sinδCP. When the external constraint on sin2θ13 is removed, sin2θ13=28.0-6.5+2.8×10-3, in agreement with measurements from reactor experiments. These results are consistent with previous T2K analyses.
Published: 2023

37. Information Thermodynamics for Deterministic Chemical Reaction Networks

Author: Penocchio, Emanuele, Avanzini, Francesco, and Esposito, Massimiliano
Subjects: Condensed Matter - Statistical Mechanics
Abstract: Information thermodynamics relates the rate of change of mutual information between two interacting subsystems to their thermodynamics when the joined system is described by a bipartite stochastic dynamics satisfying local detailed balance. Here, we expand the scope of information thermodynamics to deterministic bipartite chemical reaction networks, namely, composed of two coupled subnetworks sharing species, but not reactions. We do so by introducing a meaningful notion of mutual information between different molecular features, that we express in terms of deterministic concentrations. This allows us to formulate separate second laws for each subnetwork, which account for their energy and information exchanges, in complete analogy with stochastic systems. We then use our framework to investigate the working mechanisms of a model of chemically-driven self-assembly and an experimental light-driven bimolecular motor. We show that both systems are constituted by two coupled subnetworks of chemical reactions. One subnetwork is maintained out of equilibrium by external reservoirs (chemostats or light sources) and powers the other via energy and information flows. In doing so, we clarify that the information flow is precisely the thermodynamic counterpart of an information ratchet mechanism only when no energy flow is involved., Comment: 18 pages, 3 figures
Published: 2022
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38. Acoustics-specific Piano Velocity Estimation

Author: Simonetta, Federico, Ntalampiras, Stavros, and Avanzini, Federico
Subjects: Computer Science - Sound, Computer Science - Machine Learning, Electrical Engineering and Systems Science - Audio and Speech Processing
Abstract: Motivated by the state-of-art psychological research, we note that a piano performance transcribed with existing Automatic Music Transcription (AMT) methods cannot be successfully resynthesized without affecting the artistic content of the performance. This is due to 1) the different mappings between MIDI parameters used by different instruments, and 2) the fact that musicians adapt their way of playing to the surrounding acoustic environment. To face this issue, we propose a methodology to build acoustics-specific AMT systems that are able to model the adaptations that musicians apply to convey their interpretation. Specifically, we train models tailored for virtual instruments in a modular architecture that takes as input an audio recording and the relative aligned music score, and outputs the acoustics-specific velocities of each note. We test different model shapes and show that the proposed methodology generally outperforms the usual AMT pipeline which does not consider specificities of the instrument and of the acoustic environment. Interestingly, such a methodology is extensible in a straightforward way since only slight efforts are required to train models for the inference of other piano parameters, such as pedaling., Comment: Submitted at MMSP 2022
Published: 2022

39. A Perceptual Measure for Evaluating the Resynthesis of Automatic Music Transcriptions

Author: Simonetta, Federico, Avanzini, Federico, and Ntalampiras, Stavros
Subjects: Computer Science - Sound, Computer Science - Machine Learning, Electrical Engineering and Systems Science - Audio and Speech Processing
Abstract: This study focuses on the perception of music performances when contextual factors, such as room acoustics and instrument, change. We propose to distinguish the concept of "performance" from the one of "interpretation", which expresses the "artistic intention". Towards assessing this distinction, we carried out an experimental evaluation where 91 subjects were invited to listen to various audio recordings created by resynthesizing MIDI data obtained through Automatic Music Transcription (AMT) systems and a sensorized acoustic piano. During the resynthesis, we simulated different contexts and asked listeners to evaluate how much the interpretation changes when the context changes. Results show that: (1) MIDI format alone is not able to completely grasp the artistic intention of a music performance; (2) usual objective evaluation measures based on MIDI data present low correlations with the average subjective evaluation. To bridge this gap, we propose a novel measure which is meaningfully correlated with the outcome of the tests. In addition, we investigate multimodal machine learning by providing a new score-informed AMT method and propose an approximation algorithm for the $p$-dispersion problem., Comment: Accepted by Multimedia Tools and Applications (2022); supplementary materials are in the latex sources
Published: 2022
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40. Study of final-state interactions of protons in neutrino-nucleus scattering with INCL and NuWro cascade models

Author: Ershova, A., Bolognesi, S., Letourneau, A., David, J. -C., Dolan, S., Hirtz, J., Niewczas, K., Sobczyk, J. T., Blanchet, A., Avanzini, M. Buizza, Chakrani, J., Cugnon, J., Giganti, C., Hassani, S., Juszczak, C., Munteanu, L., Nguyen, V. Q., Sgalaberna, D., and Suvorov, S.
Subjects: High Energy Physics - Phenomenology
Abstract: The modeling of neutrino-nucleus interactions constitutes a challenging source of systematic uncertainty for the extraction of precise values of neutrino oscillation parameters in long-baseline accelerator neutrino experiments. To improve such modeling and minimize the corresponding uncertainties, a new generation of detectors is being developed, which aim to measure the complete final state of particles resulting from neutrino interactions. In order to fully benefit from the improved detector capabilities, precise simulations of the nuclear effects on the final-state nucleons are needed. This article presents the study of the in-medium propagation of knocked-out protons, i.e., final-state interactions (FSI), comparing the NuWro and INCL cascade models. The INCL model is used here for the first time to predict exclusive final states of neutrino interactions. This study of INCL in the framework of neutrino interactions features various novelties, including the production of nuclear clusters (e.g., deuterons, $\alpha$ particles) in the final state. The paper includes a complete characterization of the final state after FSI, comparisons to available measurements of single transverse variables, and an assessment of the observability of nuclear clusters., Comment: 19 pages, 19 figures
Published: 2022
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41. Parametrising CCQE uncertainties in the Spectral Function model for neutrino oscillation analyses

Author: Chakrani, Jaafar, Avanzini, Margherita Buizza, and Dolan, Stephen
Subjects: High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract: A substantial fraction of systematic uncertainties in neutrino oscillation experiments stems from the lack of precision in modeling the nucleus when describing the neutrino-nucleus interactions. The Spectral Function (SF) model features a distribution of momenta and removal energies of nucleons inside the nucleus within the shell-model picture, and also accounts for short-range correlations between nucleons. These characteristics offer significant improvements with respect to the more commonly used Fermi gas-based models. Electron scattering experiments offer a precise probe of the structure of the nucleus and have been used to both construct and validate the SF model. SF is thus an interesting reference model for long baseline neutrino experiments. Based on constraints from electron scattering data, we develop a set of parameters that can alter the occupancy of the nuclear shells and the distribution of the nucleon momentum within each shell. In addition, the impact of final-state interactions on the outgoing lepton and nucleon kinematics, the contribution of short-range correlations and the effect of Pauli blocking can also be modified. In this document, we will first describe the development of these parameters, partially based on a comparison with electron scattering data. We then show fits of these parameters to available T2K and MINER$\nu$A cross-section data and discuss how they can be used to constrain the systematic uncertainties related to the SF model in neutrino oscillation analyses.
Published: 2022
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42. The Double Chooz antineutrino detectors

Author: Double Chooz Collaboration, de Kerret, H., Abe, Y., Aberle, C., Abrahão, T., Ahijado, J. M., Akiri, T., Alarcón, J. M., Alba, J., Almazan, H., Anjos, J. C. dos, Appel, S., Ardellier, F., Barabanov, I., Barriere, J. C., Baussan, E., Baxter, A., Bekman, I., Bergevin, M., Bernstein, A., Bertoli, W., Bezerra, T. J. C., Bezrukov, L., Blanco, C., Bleurvacq, N., Blucher, E., Bonet, H., Bongrand, M., Bowden, N. S, Brugière, T., Buck, C., Avanzini, M. Buizza, Busenitz, J., Cabrera, A., Calvo, E., Camilleri, L., Carr, R., Cazaux, S., Cela, J. M., Cerrada, M., Chang, P. J., Charon, P., Chauveau, E., Chimenti, P., Classen, T., Collin, A. P., Conover, E., Conrad, J. M, Cormon, S., Corpace, O., Courty, B., Crespo-Anadón, J. I., Cribier, M., Crum, K., Cuadrado, S., Cucoanes, A., D'Agostino, M., Damon, E., Dawson, J. V., Dazeley, S., Dierckxsens, M., Dietrich, D., Djurcic, Z., Dorigo, F., Dracos, M., Durand, V., Efremekov, Y., Elnimr, M., Etenko, A., Falk, E., Fallot, M., Fechner, M., Felde, J., Fernandes, S. M., Fernández-Bedoya, C., Francia, D., Franco, D., Fischer, V., Franke, A. J., Franke, M., Furuta, H., Garcia, F., Garcia, J., Gil-Botella, I., Giot, L., Givaudan, A., Göger-Neff, M., Gomez, H., Gonzalez, L. F. G., Goodenough, L., Goodman, M. C., Goon, J., Gramlich, B., Greiner, D., Guertin, A., Guillon, B., Habib, S. M., Haddad, Y., Hara, T., Hartmann, F. X., Hartnell, J., Haser, J., Hatzikoutelis, A., Hellwig, D., Hervé, S., Hofacker, R., Horton-Smith, G., Hourlier, A., Ishitsuka, M., Jänner, K., Jiménez, S., Jochum, J., Jollet, C., Kaether, F., Kale, K., Kalousis, L., Kamyshkov, Y., Kaneda, M., Kaplan, D. M., Karakac, M., Kawasaki, T., Kemp, E., Kibe, Y., Kirchner, T., Konno, T., Kryn, D., Kutter, T., Kuze, M., Lachenmaier, T., Lane, C. E., Langbrandtner, C., Lasserre, T., Lastoria, C., Latron, L., Leonardo, C., Letourneau, A., Lhuillier, D., Lima Jr, H. P., Lindner, M., López-Castaño, J. M., LoSecco, J. M., Lubsandorzhiev, B., Lucht, S., Maeda, J., Maesano, C. N., Mariani, C., Maricic, J., Marie, F., Martinez, J. J., Martino, J., Matsubara, T., McKee, D., Meigner, F., Mention, G., Meregaglia, A., Meyer, J. P., Miletic, T., Milincic, R., Millot, J. F., Minotti, A., Mirones, V., Miyata, H., Mueller, Th. A., Nagasaka, Y., Nakajima, K., Navas-Nicolás, D., Nikitenko, Y., Novella, P., Oberauer, L., Obolensky, M., Onillon, A., Oralbaev, A., Ostrovskiy, I., Palomares, C., Peeters, S. J. M., Pepe, I. M., Perasso, S., Perrin, P., Pfahler, P., Porta, A., Pronost, G., Puras, J. C., Quéval, R., Ramirez, J. L., Reichenbacher, J., Reinhold, B., Reissfelder, M., Remoto, A., Reyna, D., Rodriguez, I., Röhling, M., Roncin, R., Rudolf, N., Rybolt, B., Sakamoto, Y., Santorelli, R., Sato, F., Schwan, U., Scola, L., Settimo, M., Schönert, S., Schoppmann, S., Shaevitz, M. A., Sharankova, R., Sibille, V., Sida, J. L., Sinev, V., Shrestha, D., Skorokhvatov, M., Soldin, P., Spitz, J., Stahl, A., Stancu, I., Starzynski, P., Stock, M. R., Stokes, L. F. F., Strait, M., Stüken, A., Suekane, F., Sukhotin, S., Sumiyoshi, T., Sun, Y., Sun, Z., Svoboda, R., Tabata, H., Tamura, N., Terao, K., Tonazzo, A., Toral, F., Toups, M., Thi, H. Trinh, Valdivia, F., Valdiviesso, G., Vassilopoulos, N., Verdugo, A., Veyssiere, C., Viaud, B., Vignaud, D., Vivier, M., Wagner, S., Wiebusch, C., White, B., Winslow, L., Worcester, M., Wurm, M., Wurtz, J., Yang, G., Yáñez, J., Yermia, F., and Zbiri, K.
Subjects: Physics - Instrumentation and Detectors
Abstract: This article describes the setup and performance of the near and far detectors in the Double Chooz experiment. The electron antineutrinos of the Chooz nuclear power plant were measured in two identically designed detectors with different average baselines of about 400 m and 1050 m from the two reactor cores. Over many years of data taking the neutrino signals were extracted from interactions in the detectors with the goal of measuring a fundamental parameter in the context of neutrino oscillation, the mixing angle {\theta}13. The central part of the Double Chooz detectors was a main detector comprising four cylindrical volumes filled with organic liquids. From the inside towards the outside there were volumes containing gadolinium-loaded scintillator, gadolinium-free scintillator, a buffer oil and, optically separated, another liquid scintillator acting as veto system. Above this main detector an additional outer veto system using plastic scintillator strips was installed. The technologies developed in Double Chooz were inspiration for several other antineutrino detectors in the field. The detector design allowed implementation of efficient background rejection techniques including use of pulse shape information provided by the data acquisition system. The Double Chooz detectors featured remarkable stability, in particular for the detected photons, as well as high radiopurity of the detector components., Comment: 49 pages, 29 figures
Published: 2022
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43. Quantum Expectation Transformers for Cost Analysis

Author: Avanzini, Martin, Moser, Georg, Péchoux, Romain, Perdrix, Simon, and Zamdzhiev, Vladimir
Subjects: Quantum Physics, Computer Science - Logic in Computer Science, Computer Science - Programming Languages
Abstract: We introduce a new kind of expectation transformer for a mixed classical-quantum programming language. Our semantic approach relies on a new notion of a cost structure, which we introduce and which can be seen as a specialisation of the Kegelspitzen of Keimel and Plotkin. We show that our weakest precondition analysis is both sound and adequate with respect to the operational semantics of the language. Using the induced expectation transformer, we provide formal analysis methods for the expected cost analysis and expected value analysis of classical-quantum programs. We illustrate the usefulness of our techniques by computing the expected cost of several well-known quantum algorithms and protocols, such as coin tossing, repeat until success, entangled state preparation, and quantum walks.
Published: 2022
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44. Comparisons and challenges of modern neutrino-scattering experiments (TENSIONS 2019 report)

Author: Avanzini, M. Buizza, Betancourt, M., Cherdack, D., Del Tutto, M., Dytman, S., Furmanski, A. P., Gardiner, S., Hayato, Y., Koch, L., Mahn, K., Mastbaum, A., Messerly, B., Riccio, C., Ruterbories, D., Sobczyk, J., Wilkinson, C., and Wret, C.
Subjects: High Energy Physics - Experiment
Abstract: A set of comparisons among neutrino interaction experiments (MiniBooNE, MINERvA, T2K, and MicroBooNE) is presented. This gives a broad view of the field of neutrino-nucleus interactions. The emphasis is on charged current inclusive, quasielastic-like, and pion production experiments. Measurements are compared in new ways. Comparisons of recent data with available event generator codes are made more comprehensively than is regularly found in most previous publications. Generator studies show sensitivities for experimental model dependence. Effciencies calculated with different generators are presented in a novel way. A comparison of different forward folding techniques is also presented., Comment: 61 pages, 43 figures
Published: 2021

45. Thermodynamics of Concentration vs Flux Control in Chemical Reaction Networks

Author: Avanzini, Francesco and Esposito, Massimiliano
Subjects: Condensed Matter - Statistical Mechanics, Physics - Chemical Physics
Abstract: We investigate the thermodynamic implications of two control mechanisms of open chemical reaction networks. The first controls the concentrations of the species that are exchanged with the surroundings, while the other controls the exchange fluxes. We show that the two mechanisms can be mapped one into the other and that the thermodynamic theories usually developed in the framework of concentration control can be applied to flux control as well. This implies that the thermodynamic potential and the fundamental forces driving chemical reaction networks out of equilibrium can be identified in the same way for both mechanisms. By analyzing the dynamics and thermodynamics of a simple enzymatic model we also show that, while the two mechanisms are equivalent at steady state, the flux control may lead to fundamentally different regimes where systems achieve stationary growth.
Published: 2021
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46. Beyond image defined risk factors (IDRFs): a delphi survey highlighting definition of the surgical complexity index (SCI) in neuroblastoma

Author: Avanzini, S., Dall’Igna, P., Bjornland, K., Braungart, S., Cross, K., Flores, P., Gabra, H. O. S., Gomez-Chacon, J., Irtan, S., Lobos, P., Loh, A., Matthyssens, L. E., Metzelder, M., Parodi, S., Pio, L., Van de Ven, C. P., Fuchs, J., Losty, P. D., and Sarnacki, S.
Published: 2023
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47. The importance of observing the master’s hand: Action Observation Training promotes the acquisition of new musical skills

Author: Simone Paolini, Maria Chiara Bazzini, Laura Ferrari, Antonino Errante, Leonardo Fogassi, Giacomo Rizzolatti, Maddalena Fabbri-Destro, Pietro Avanzini, and Arturo Nuara
Subjects: mirror mechanism, motor learning, motor similarity, musical training, music pedagogy, Neurology. Diseases of the nervous system, RC346-429
Abstract: IntroductionVia mirror mechanism, motor training approaches based on the alternation of action observation and execution (i.e., Action Observation Training-AOT) promote the acquisition of motor abilities. Previous studies showed that both visual and auditory stimuli may elicit a common motor representation of music-related gestures; however, the potentialities of AOT for the acquisition of musical skills are still underexplored.MethodsTwenty-one music-naïve participants underwent two blocks of training: AOT and Key-light Observation Training (KOT). AOT consisted of the observation of a melodic sequence played on a keyboard with the right hand by an expert model, followed by participant’s imitation. Observation and execution were repeated six consecutive times (T1–T6). KOT followed the same procedure, except for the visual content of the stimulus, depicting the sequential highlighting of the piano keys corresponding to the melody. The rate of correct notes (C), the trainee-model similarity of key-pressure strength (S), and the trainee-model consistency of note duration (R) were collected across T1–T6.ResultsBoth AOT and KOT improved musical performance. Noteworthy, AOT showed a higher learning magnitude relative to KOT in terms of C and S.DiscussionAction Observation Training promotes the acquisition of key elements of melodic sequences, encompassing not only the accurate sequencing of notes but also their expressive characteristics, such as key-pressure dynamics. The convergence of listening and observation of actions onto a shared motor representation not only explains several pedagogical approaches applied in all musical cultures worldwide, but also enhances the potential efficacy of current procedures for music training.
Published: 2024
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48. Calcium oscillations optimize the energetic efficiency of mitochondrial metabolism

Author: Valérie Voorsluijs, Francesco Avanzini, Gianmaria Falasco, Massimiliano Esposito, and Alexander Skupin
Subjects: Natural sciences, Biological sciences, Human metabolism, Molecular biology, Science
Abstract: Summary: Energy transduction is central to living organisms, but the impact of enzyme regulation and signaling on its thermodynamic efficiency is generally overlooked. Here, we analyze the efficiency of ATP production by the tricarboxylic acid cycle and oxidative phosphorylation, which generate most of the chemical energy in eukaryotes. Calcium signaling regulates this pathway and can affect its energetic output, but the concrete energetic impact of this cross-talk remains elusive. Calcium enhances ATP production by activating key enzymes of the tricarboxylic acid cycle while calcium homeostasis is ATP-dependent. We propose a detailed kinetic model describing the calcium-mitochondria cross-talk and analyze it using nonequilibrium thermodynamics: after identifying the effective reactions driving mitochondrial metabolism out of equilibrium, we quantify the mitochondrial thermodynamic efficiency for different conditions. Calcium oscillations, triggered by extracellular stimulation or energy deficiency, boost the thermodynamic efficiency of mitochondrial metabolism, suggesting a compensatory role of calcium signaling in mitochondrial bioenergetics.
Published: 2024
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49. Sensitivity of the Upgraded T2K Near Detector to constrain neutrino and anti-neutrino interactions with no mesons in the final state by exploiting nucleon-lepton correlations

Author: Dolan, S., Nguyen, V. Q., Blanchet, A., Bolognesi, S., Avanzini, M. Buizza, Chakrani, J., Ershova, A., Giganti, C., Kudenko, Y., Lamoureux, M., Letourneau, A., Martini, M., McGrew, C., Munteanu, L., Popov, B., Sgalaberna, D., Suvorov, S., and Zhao, X. Y.
Subjects: High Energy Physics - Experiment
Abstract: The most challenging and impactful uncertainties that future accelerator-based measurements of neutrino oscillations must overcome stem from our limited ability to model few-GeV neutrino-nucleus interactions. In particular, it is crucial to better understand the nuclear effects which can alter the final state topology and kinematics of neutrino interactions, inducing possible biases in neutrino energy reconstruction. The upgraded ND280 near detector of the T2K experiment will directly confront neutrino interaction uncertainties using a new suite of detectors with full polar angle acceptance, improved spatial resolutions, neutron detection capabilities and reduced tracking thresholds. In this manuscript we explore the physics sensitivity that can be expected from the upgraded detector, specifically focusing on the additional sensitivity to nuclear effects and how they can be constrained with future measurements of kinematic variables constructed using both outgoing lepton and nucleon kinematics., Comment: 13 pages, 13 figures, minor corrections from V1
Published: 2021
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50. Audio-to-Score Alignment Using Deep Automatic Music Transcription

Author: Simonetta, Federico, Ntalampiras, Stavros, and Avanzini, Federico
Subjects: Computer Science - Sound, Computer Science - Multimedia, Electrical Engineering and Systems Science - Audio and Speech Processing
Abstract: Audio-to-score alignment (A2SA) is a multimodal task consisting in the alignment of audio signals to music scores. Recent literature confirms the benefits of Automatic Music Transcription (AMT) for A2SA at the frame-level. In this work, we aim to elaborate on the exploitation of AMT Deep Learning (DL) models for achieving alignment at the note-level. We propose a method which benefits from HMM-based score-to-score alignment and AMT, showing a remarkable advancement beyond the state-of-the-art. We design a systematic procedure to take advantage of large datasets which do not offer an aligned score. Finally, we perform a thorough comparison and extensive tests on multiple datasets., Comment: IEEE MMSP 2021 - ERRATUM
Published: 2021

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