48 results on '"Avallone, M."'
Search Results
2. Topic: Rare and Special Cases, The Real “Strange Cases”
- Author
-
Zarrinkhoo, E., Miller, J., Walker, A., Weisman, M., Towfigh, S., Tushev, R., Petkov, I., Tsutsumi, G., Leija, C., Castillo, E., Moncada, F., Mendoza, M., Morua, A. Garcia, Bravo, R., Azcarate, A., Zavala, H., Coman, I. S., Radu, E. V., David, O. I., Stoian, A. R., Strambu, V. E., Iancu, C., Gheorghiu, L. I., Grigorean, V. T., Sinescu, D. R., Plesa, E., Lupascu, C., Straja, D. N., Iacobini, M. A., Ponten, J., Luyer, M., Nienhuijs, S., Permekerlis, A., Petousis, S., Miroforidis, A., Milias, K., Kouridakis, P., Park, J., Kim, D., Nakata, R., Chihara, N., Suzuki, H., Watanabe, M., Uchida, E., Nakanaga, H., Irie, S., Endo, Y., Sonoda, H., Minamimura, K., Kobayashi, T., Hirata, T., Mafune, K., Milosevic, P., Babovic, M., Sorat, D., Light, D., Aawsaj, Y., Horgan, L., Latham, L., Ceriani, I., Livraghi, L., Berselli, M., Gambitta, B., Galvanin, J., Cotronea, C., Pagano, G., Farassino, L., Ambrosoli, A., Crespi, A., Cocozza, E., Kulic, V., Matkovic, M., Percevic, G., Katayama, T., Kumata, Y., Ogawa, E., Horikawa, M., Yaguchi, Y., Inaba, T., Fukushima, R., Jaroszewski, D., Johnson, K., Harold, K., Mori, M., Kumata, M., Guarnieri, F., Smaldone, W., Gaspard, M., Bomben, F., Ceranto, S., Gamarra, M. Florez, Soria, M. Peña, Olivero, C. Fraile, Martinez, M. Josa, Contin, M. Perez, Gómez, J. Cabeza, Jiménez-Valladolid, D., Torres García, A., Descloux, A., Pohle, S., Schramm, B., Schneider, U., Nocito, A., Navarrete, M. Cesardo, Solis, A., Ortega, N., Bergamini, S., Semeraro, C., Armengol, M., Cano, M. Lopez, Torrecilla, N. Ortega, Cavallaro, G., Iorio, O., Avallone, M., Ruscio, S., Rizzello, M., Silecchia, G., Butron, T., Rubio, E., Passas, J., Sopeña, R., Lagaron, E., Silan, F., Garcia, V., Bernal, J., Ortiz, M., Guadarrama, J., Shirai, K., Lomas, M., Shah, B. Bc, and Degloorkar, S. Sarang
- Published
- 2015
- Full Text
- View/download PDF
3. Characterization of gut microbiota in patients with metabolic syndrome candidates for bariatric/metabolic surgery: Preliminary findings of a multi-center prospective study
- Author
-
De Maio, F., Boru, C. E., Avallone, M., Velotti, N., Bianco, D. M., Capoccia, D., Greco, F., Guarisco, G., Nogara, M., Sanguinetti, M., Verrastro, O., Capaldo, B., Musella, M., Raffaelli, M., Delogu, G., Silecchia, G., Leonetti, F., De Maio F., Greco F., Sanguinetti M. (ORCID:0000-0002-9780-7059), Verrastro O., Musella M., Raffaelli M. (ORCID:0000-0002-1259-2491), Delogu G. (ORCID:0000-0003-0182-8267), De Maio, F., Boru, C. E., Avallone, M., Velotti, N., Bianco, D. M., Capoccia, D., Greco, F., Guarisco, G., Nogara, M., Sanguinetti, M., Verrastro, O., Capaldo, B., Musella, M., Raffaelli, M., Delogu, G., Silecchia, G., Leonetti, F., De Maio F., Greco F., Sanguinetti M. (ORCID:0000-0002-9780-7059), Verrastro O., Musella M., Raffaelli M. (ORCID:0000-0002-1259-2491), and Delogu G. (ORCID:0000-0003-0182-8267)
- Abstract
Introduction: gut microbiota (GM) seems to be involved in the pathophysiology and progression of both metabolic syndrome (MS) and obesity. The aim was to investigate GM's composition in patients with severe obesity, candidates for bariatric/metabolic surgery BMS. Materials and Methods: Multicentre, prospective, cohort study, enrolling 84 patients with BMI 40–55 kg/m2, divided by metabolic status (MS) in healthy (group A), pre-MS (B), or MS (C). Results: No differences were found regarding anthropometric, nutritional parameters, except for vitamin D. As a whole the alpha and beta diversity examinations showed no statistical differences in GM profile. A total of 5/7 phyla with relative frequencies were identified above 0.1% (Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria, Verrucomicrobia). Fusobacteria and Patescibacteria represented the less abundant. There were no significant differences in the top ten genera. Data on Bacteroidetes (inversely related to triglycerides and LDL and directly related to HDL levels) and on Firmicutes (opposite trend) relative abundances suggest no differences among the three conditions. No correlation between the relative abundance of the main phyla and plasmatic glucose levels was observed. Conclusions: In a selected cohort of patients with obesity, MS did not affect the preoperative GM's profile. Severe obesity, per se, seems to be an independent condition affecting GM.
- Published
- 2021
4. PRIMARY LUMBAR HERNIA (GRYNFELT'S AND PETIT'S HERNIA) REPAIR: 2014 UP-TO-DATE AND EXTENSIVE LITERATURE REVIEW
- Author
-
Cavallaro, G., Iorio, O., Avallone, M., Ruscio, S., Rizzello, M., and Silecchia, Gianfranco
- Published
- 2015
5. Small bowel intussussception due to metastatic melanoma of unknown primary site. Case report
- Author
-
STAGNITTI, F., ORSINI, S., MARTELLUCCI, A., TUDISCO, A., AVALLONE, M., AIUTI, F., DI GIROLAMO, V., STEFANELLI, F., DE ANGELIS, F., COSTANTINO, A., DI GRAZIA, C., NAPOLEONI, A., NICODEMI, S., CIPRIANI, B., CECI, F., MOSILLO, R., CORELLI, S., CASCIARO, G., and SPAZIANI, E.
- Subjects
Male ,Oncology ,Pathology ,medicine.medical_specialty ,Ileum ,Metastasis ,Clinical Practice ,Internal medicine ,medicine ,Humans ,Malignant melanoma ,Unknown primary ,Intestinal intussusceptions ,Disseminated disease ,Melanoma ,Gastrointestinal tract ,business.industry ,Middle Aged ,medicine.disease ,Ileal Neoplasms ,medicine.anatomical_structure ,Iron-deficiency anemia ,Neoplasms, Unknown Primary ,Segmental resection ,business ,Intestinal Obstruction ,Brain metastasis - Abstract
Malignant melanoma is characterized by metastases also to the gastrointestinal tract, especially in the small bowel. The diagnosis is often delayed because unspecific clinical presentation (frequently as chronic iron deficiency anemia, rectal bleeding or intestinal obstruction). We present a case of melanoma of unknown primary site, with clinical presentation of intestinal obstruction. A segmental resection of the ileum was performed including mesentery with lymph nodes. Histology revealed metastatic melanoma from unknown primary. PET and MRI confirmed disseminated disease without brain metastasis.
- Published
- 2014
6. Risk management in surgery
- Author
-
Messano, GIUSEPPE ALESSIO, Spaziani, Erasmo, Turchetta, F., Ceci, F., Corelli, S., Casciaro, Giovanni Enrico, Martellucci, A., Costantino, A., Napoleoni, A., Cipriani, B., Nicodemi, S., Di Grazia, C., Mosillo, R., Avallone, M., Orsini, S., Tudisco, A., Aiuti, F., and Stagnitti, Franco
- Subjects
antibiotic therapy ,laparoscopic drainage ,liver abscesses ,percutaneous drainage ,risk management ,Risk Management ,Italy ,Surgical Procedures, Operative ,Humans ,Focus on ,Checklist - Abstract
Malpractice is the responsible for the greatest number of legal claims. At the present time, legal actions against physicians in Italy are 15,000 per year, and a stunning increase about costs to refund patients injured by therapeutic and diagnostic errors is expected. The method for the medical prevention is “Risk Management”, that is the setting-up of organizational instruments, methods and actions that enable the measurement or estimation of medical risk; it allows to develop strategies to govern and reduce medical error. In the present work, the reconstruction about the history of risk management in Italy was carried out. After then the latest initiatives undertaken by Italy about the issue of risk management were examined.
- Published
- 2013
7. Correlation between Rarebit perimetry and Frequency Doubling Technology in glaucomatous patients
- Author
-
Mete, M, Iester, Michele, Zambelli, A, Avallone, M, Corallo, Guido, Ferro, C, and Calabria, G.
- Published
- 2008
8. Surgical pathology of benign breast diseases
- Author
-
Pettinato, G., Panico, L., De Rosa, N., D'Antonio, Antonio, Bifano, D., and Avallone, M.
- Subjects
Benign ,Excisional ,Biopsy ,Pathology ,Disease ,Breast - Published
- 1997
9. Biliodigestive fistulae and gallstone ileus: diagnostic and therapeutic considerations. Our experience.
- Author
-
STAGNITTI, F., TUDISCO, A., CECI, F., NICODEMI, S., ORSINI, S., AVALLONE, M., DI GIROLAMO, V., STEFANELLI, F., DE ANGELIS, F., DI GRAZIA, C., CIPRIANI, B., AIUTI, F., NAPOLEONI, A., MOSILLO, R., CORELLI, S., CASCIARO, G., COSTANTINO, A., MARTELLUCCI, A., and SPAZIANI, E.
- Published
- 2014
10. Single-incision laparoscopic appendectomy is comparable to conventional laparoscopic and laparotomic appendectomy: our single center single surgeon experience.
- Author
-
CECI, F., ORSINI, S., TUDISCO, A., AVALLONE, M., AIUTI, F., GIROLAMO, V. DI, STEFANELLI, F., DE ANGELIS, F., MARTELLUCCI, A., COSTANTINO, A., DI GRAZIA, C., NICODEMI, S., CIPRIANI, B., NAPOLEONI, A., MOSILLO, R., CORELLI, S., CASCIARO, G., SPAZIANI, E., and STAGNITTI, F.
- Published
- 2013
11. Technique and outcomes about a new laparoscopic procedure: the Pelvic Organ Prolapse Suspension (POPS).
- Author
-
CECI, F., SPAZIANI, E., CORELLI, S., CASCIARO, G., MARTELLUCCI, A., COSTANTINO, A., NAPOLEONI, A., CIPRIANI, B., NICODEMI, S., DI GRAZIA, C., AVALLONE, M., ORSINI, S., TUDISCO, A., AIUTI, F., and STAGNITTI, F.
- Published
- 2013
12. Espressione immunoistochimica di c-erbB-2 e p53 in 650 casi consecutivi di carcinoma mammario: Correlazione con lo stato recettoriale, con la frazione di crescita e con i parametri clinico-patologici
- Author
-
Panico, L., D Antonio, A., Bifano, D., Chiacchio, R., Avallone, M., and Guido PETTINATO
13. Multiorgan female pelvic prolapse: pelvic organ prolapse suspension (P.O.P.S.) stapled transanal rectale resection (S.T.A.R.R.): new surgical tecniques and results
- Author
-
Ceci, F., Spaziani, E., giovanni casciaro, Corelli, S., Martellucci, A., Costantino, A., Nicodemi, S., Avallone, M., Orsini, S., Tudisco, A., Aiuti, F., and Stagnitti, F.
- Subjects
Gynecologic Surgical Procedures ,Surgical Stapling ,Prolapse ,S.T.A.R.R ,Rectum ,Anal Canal ,Humans ,Female ,Middle Aged ,P.O.P.S ,Pelvic Organ Prolapse - Abstract
To demonstrate the surgical treatment validity and the post-operative complication decrease.Seventythree women who underwent P.O.P.S. + S.T.A.R.R. treatment, follow-up one year.We observed an important reduction or a completely disappearance about pre-operative signs and symptoms.We are aware that the proposed technique, if taken into account by urogynecologists, will raise several arguments and will raise many doubts and perplexities. For this reason we wanted develop a follow-up sufficiently long and many case studies with data to support our claims.We believe that the procedure proposed by us, given the results, was excellent in patients with multiorgan pelvic prolapse, especially with the vagina walls elongated and that retain a good trophism.
14. The osteoclast-like giant cells breast carcinoma: Report of 13 cases with the receptorial status and follow-up data
- Author
-
D Antonio, A., Panico, L., Bifano, D., Renato Franco, Avallone, M., and Pettinato, G.
15. LIGHTWEIGHT POLYPROPYLENE MESH & ABSORBABLE TACKS IN LAPAROSCOPIC VENTRAL AND INCISIONAL HERNIA REPAIR.
- Author
-
IORIO, O., CAVALLARO, G., IOSSA, A., AVALLONE, M., RUSCIO, S., RIZZELLO, M., and SILECCHIA, G.
- Published
- 2014
16. LAPAROSCOPIC SLEEVE GASTRECTOMY AS REVISIONAL PROCEDURE FOR FAILED LAPAROSCOPIC GASTRIC BANDING WITH A "TWO-STEP APPROACH".
- Author
-
DE ANGELIS, F., IORIO, O., IOSSA, A., AVALLONE, M., PATTARO, G., LONGO, F., RUSCIO, S., CAVALLARO, G., RIZZELLO, M., and SILECCHIA, G.
- Published
- 2014
17. RESIDUAL FUNDUS OR NEOFUNDUS AFTER LAPAROSCOPIC SLEEVE GASTRECTOMY: IS FUNDECTOMY SAFE AND EFFECTIVE AS REVISION SURGERY?
- Author
-
DE ANGELIS, F., IOSSA, A., IORIO, O., AVALLONE, M., PATTARO, G., RUSCIO, S., CAVALLARO, G., RIZZELLO, M., and SILECCHIA, G.
- Published
- 2014
18. PREVALENCE OF GASTROINTESTINAL SYMPTOMS AND UPPER ENDOSCOPIC FINDINGS IN A POPULATION OF OBESE PATIENTS CANDIDATE TO BARIATRIC SURGERY: A PROSPECTIVE STUDY.
- Author
-
AVALLONE, M., CARABOTTI, M., LIGUORI, A., RIDOLFI, M., LONGO, F., RUSCIO, S., CAPOCCIA, D., SCIROCCO, A., LEONETTI, F., SEVERI, C., and SILECCHIA, G.
- Published
- 2014
19. CRITICAL APPRESIAL OF THE USE OF ENDOPROSTHESIS IN THE MANAGEMENT OF BARIATRIC SURGERY COMPLICATIONS.
- Author
-
IOSSA, A., DE ANGELIS, F., IORIO, O., RIZZELLO, M., CAVALLARO, G., AVALLONE, M., RUSCIO, S., LONGO, F., and SILECCHIA, G.
- Published
- 2014
20. Characterization of gut microbiota in patients with metabolic syndrome candidates for bariatric/metabolic surgery: Preliminary findings of a multi-center prospective study
- Author
-
M. Avallone, Cristian Eugeniu Boru, Nunzio Velotti, Brunella Capaldo, Frida Leonetti, Danila Capoccia, Flavio De Maio, Gloria Guarisco, Mario Musella, Manuela Nogara, Francesco Greco, Maurizio Sanguinetti, Marco Raffaelli, Delia Mercedes Bianco, Gianfranco Silecchia, Giovanni Delogu, Ornella Verrastro, De Maio, F., Boru, C. E., Avallone, M., Velotti, N., Bianco, D. M., Capoccia, D., Greco, F., Guarisco, G., Nogara, M., Sanguinetti, M., Verrastro, O., Capaldo, B., Musella, M., Raffaelli, M., Delogu, G., Silecchia, G., and Leonetti, F.
- Subjects
Vitamin ,medicine.medical_specialty ,Gastric bypass ,Endocrinology, Diabetes and Metabolism ,Bariatric Surgery ,Gut microbiota ,Gut flora ,ariatric/metabolic surgery ,gastric bypass ,gut microbiota ,metabolic syndrome ,obesity ,Gastroenterology ,Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA ,Cohort Studies ,chemistry.chemical_compound ,Endocrinology ,Gastric bypa ,Diabetes mellitus ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Obesity ,Prospective Studies ,Prospective cohort study ,Metabolic Syndrome ,biology ,business.industry ,General Medicine ,medicine.disease ,biology.organism_classification ,Bariatric/metabolic surgery ,Gastrointestinal Microbiome ,Prospective Studie ,chemistry ,Cohort ,Metabolic syndrome ,Cohort Studie ,business ,Cohort study ,Human - Abstract
Introduction: gut microbiota (GM) seems to be involved in the pathophysiology and progression of both metabolic syndrome (MS) and obesity. The aim was to investigate GM's composition in patients with severe obesity, candidates for bariatric/metabolic surgery BMS. Materials and Methods: Multicentre, prospective, cohort study, enrolling 84 patients with BMI 40–55 kg/m2, divided by metabolic status (MS) in healthy (group A), pre-MS (B), or MS (C). Results: No differences were found regarding anthropometric, nutritional parameters, except for vitamin D. As a whole the alpha and beta diversity examinations showed no statistical differences in GM profile. A total of 5/7 phyla with relative frequencies were identified above 0.1% (Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria, Verrucomicrobia). Fusobacteria and Patescibacteria represented the less abundant. There were no significant differences in the top ten genera. Data on Bacteroidetes (inversely related to triglycerides and LDL and directly related to HDL levels) and on Firmicutes (opposite trend) relative abundances suggest no differences among the three conditions. No correlation between the relative abundance of the main phyla and plasmatic glucose levels was observed. Conclusions: In a selected cohort of patients with obesity, MS did not affect the preoperative GM's profile. Severe obesity, per se, seems to be an independent condition affecting GM.
- Published
- 2021
21. Germinal BRCA1-2 pathogenic variants (gBRCA1-2pv) and pancreatic cancer: epidemiology of an Italian patient cohort
- Author
-
Michele Reni, M. Macchini, Maria Grazia Rodriquenz, F. Centonze, G. Tortora, I.G. Rapposelli, S. De Lorenzo, Michele Simbolo, Paola Carrera, A. Avallone, F. De Vita, S. Calzavara, C. Chiarazzo, Marina Gaule, Giulia Orsi, Alessandro Cavaliere, Margherita Ratti, L. Stuppia, M. Di Marco, C. Paratore, Michele Milella, F. de Braud, Monica Niger, Lisa Salvatore, Davide Melisi, Stefano Cascinu, L.G. Forti, G. Giordano, M.M. Valente, Massimo Falconi, U. Peretti, U. Peretti, A. Cavaliere, M. Niger, G. Tortora, M. C. Di Marco, M. G. Rodriquenz, F. Centonze, I. G. Rapposelli, G. Giordano, F. De Vita, L. Stuppia, A. Avallone, M. Ratti, C. Paratore, L. G. Forti, G. Orsi, M. M. Valente, M. Gaule, M. Macchini, P. Carrera, S. Calzavara, M. Simbolo, D. Melisi, F. De Braud, L. Salvatore, S. De Lorenzo, C. Chiarazzo, M. Falconi, S. Cascinu, M. Milella, M. Reni, Peretti, U, Cavaliere, A, Niger, M, Tortora, G, Di Marco, M C, Rodriquenz, M G, Centonze, F, Rapposelli, I G, Giordano, G, De Vita, F, Stuppia, L, Avallone, A, Ratti, M, Paratore, C, Forti, L G, Orsi, G, Valente, M M, Gaule, M, Macchini, M, Carrera, P, Calzavara, S, Simbolo, M, Melisi, D, De Braud, F, Salvatore, L, De Lorenzo, S, Chiarazzo, C, Falconi, M, Cascinu, S, Milella, M, Reni, M, Peretti, U., Cavaliere, A., Niger, M., Tortora, G., Di Marco, M. C., Rodriquenz, M. G., Centonze, F., Rapposelli, I. G., Giordano, G., De Vita, F., Stuppia, L., Avallone, A., Ratti, M., Paratore, C., Forti, L. G., Orsi, G., Valente, M. M., Gaule, M., Macchini, M., Carrera, P., Calzavara, S., Simbolo, M., Melisi, D., De Braud, F., Salvatore, L., De Lorenzo, S., Chiarazzo, C., Falconi, M., Cascinu, S., Milella, M., and Reni, M.
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Adenocarcinoma ,familial cancer ,Prostate cancer ,Pancreatic cancer ,Internal medicine ,Epidemiology ,Medicine ,Humans ,Family history ,Germ-Line Mutation ,Aged ,Original Research ,pancreatic cancer genetics ,Aged, 80 and over ,BRCA2 Protein ,business.industry ,BRCA1 Protein ,Incidence (epidemiology) ,Middle Aged ,pancreatic cancer genetic ,medicine.disease ,germline BRCA, epidemiology, pancreatic cancer genetics, familial cancer ,Pancreatic Neoplasms ,Exact test ,Oncology ,Italy ,germline BRCA ,Cohort ,Female ,epidemiology ,business ,Human - Abstract
Objective Germline BRCA1-2 pathogenic variants (gBRCApv) increase the risk of pancreatic cancer and predict for response to platinating agents and poly(ADP-ribose) polymerase inhibitors. Data on worldwide gBRCApv incidence among pancreatic ductal adenocarcinoma (PDAC) patients are sparse and describe a remarkable geographic heterogeneity. The aim of this study is to analyze the epidemiology of gBRCApv in Italian patients. Materials and methods Patients of any age with pancreatic adenocarcinoma, screened within 3 months from diagnosis for gBRCApv in Italian oncologic centers systematically performing tests without any selection. For the purposes of our analysis, breast, ovarian, pancreas, and prostate cancer in a patient's family history was considered as potentially BRCA-associated. Patients or disease characteristics were examined using the χ2 test or Fisher's exact test for qualitative variables and the Student's t-test or Mann–Whitney test for continuous variables, as appropriate. Results Between June 2015 and May 2020, 939 patients were tested by 14 Italian centers; 492 (52%) males, median age 62 years (range 28-87), 569 (61%) metastatic, 273 (29%) with a family history of potentially BRCA-associated cancers. gBRCA1-2pv were found in 76 patients (8.1%; 9.1% in metastatic; 6.4% in non-metastatic). The gBRCA2/gBRCA1 ratio was 5.4 : 1. Patients with gBRCApv were younger compared with wild-type (59 versus 62 years, P = 0.01). The gBRCApv rate was 17.1% among patients 70 years old (none out of 94 patients >73 years old). gBRCApv frequency in 845 patients, Highlights • This is the largest case series of incident PDAC patients screened for germline BRCA1-2 pathologic variants (gBRCApv). • The incidence of gBRCA1-2pv was 8.1% in the whole population; 9.1% in metastatic patients; 6.4% in non-metastatic patients. • No gBRCA1-2pv was observed over the age of 73. • These data suggest screening all PDAC patients
- Published
- 2020
22. Preventive cognitive protection based on AAV9 overexpression of IGF1 in hippocampal astrocytes.
- Author
-
Peralta F, Vidal Escobedo AA, Hanotte JL, Avallone M, Björklund T, Reggiani PC, and Pardo J
- Subjects
- Animals, Rats, Male, Rats, Wistar, Glial Fibrillary Acidic Protein metabolism, Astrocytes metabolism, Insulin-Like Growth Factor I metabolism, Insulin-Like Growth Factor I genetics, Hippocampus metabolism, Dependovirus genetics
- Abstract
Astrocytes play key roles in the brain. When astrocyte support fails, neurological disorders follow, resulting in disrupted synaptic communication, neuronal degeneration, and cell death. We posit that astrocytes overexpressing neurotrophic factors, such as Insulin Like Growth Factor 1 (IGF1), prevent the onset of neurodegeneration. We overexpressed IGF1 and the reporter TdTomato (TOM) in hippocampal astrocytes with bicistronic Adeno-Associated Virus (AAV) harboring the Glial Fibrillary Acidic Protein (GFAP) promoter and afterwards induced neurodegeneration by the intracerebroventricular (ICV) injection of streptozotocin (STZ), a rat model of behavioral impairment, neuroinflammation and shortening of hippocampal astrocytes. We achieved a thorough transgene expression along the hippocampus with a single viral injection. Although species typical behavior was impaired, memory deficit was prevented by IGF1. STZ prompted astrocyte shortening, albeit the length of these cells in animals injected with GFP and IGF1 vectors did not statistically differ from the other groups. In STZ control animals, hippocampal microglial reactive cells increased dramatically, but this was alleviated in IGF1 rats. We conclude that overexpression of IGF1 in astrocytes prevents neurodegeneration onset. Hence, individuals with early neurotrophic exhaustion would be vulnerable to age-related neurodegeneration., Competing Interests: Declaration of competing interest The authors have no competing interests to declare., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
23. Addressing the 2021 Essentials with new approaches for developing leadership, resilience, and self-care/well-being in undergraduate baccalaureate nursing students.
- Author
-
Stubin CA, Avallone M, and Manno MS
- Subjects
- Humans, Burnout, Professional prevention & control, Curriculum, Education, Nursing, Baccalaureate, Leadership, Students, Nursing psychology, Resilience, Psychological, Self Care
- Abstract
Introduction: New graduate nurses are not always prepared for the challenges of the chaotic clinical environment or to exercise leadership skills in a clinical capacity. Resilience and self-care are essential facets of successful leadership, as well as necessary components to prevent burnout in nurses., Purpose: The purpose of this article is to demonstrate how this School of Nursing implemented approaches to prepare the next generation of nurses with strong skills in the areas of leadership, resilience, and self-care/well-being while addressing the Essentials., Methods: Faculty explored new ideas, as well as showcased teaching strategies they had already successfully implemented, that aligned with the Essentials with the undergraduate baccalaureate pilot student cohort., Results: Two "Essential" Competencies, Domain 9 Professionalism and Domain 10 Personal, Professional and Leadership Development, as well as related sub-competencies, were addressed by the thirteen teaching strategies. Anecdotal student reflection comments supported high levels of satisfaction with these strategies., Conclusions: Preparing student nurses to meet the Essentials is critical to helping nurses thrive in contemporary practice settings. Equipping a generation of nurses with self-care practices to protect their own well-being, while at the same time meeting the Essentials expectations, is crucial to cultivating a sustainable nursing workforce., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
24. Utilizing the 4Ms framework to create a structure and process to support voluntary health assessments in affordable housing.
- Author
-
Perweiler E, DeGennaro J, Pomerantz S, Mock M, Avallone M, Truchil A, and Singer S
- Subjects
- Humans, Female, Male, Aged, Risk Assessment methods, Housing for the Elderly, United States, Geriatric Assessment methods
- Abstract
Background: A growing number of older adults live in senior affordable housing, many with limited support systems and representing underserved or disadvantaged populations. Staff in these buildings are in a unique position to identify and address the healthcare and biopsychosocial needs of their residents and link them to services and supports., Methods: Staff in four affordable housing sites received training on the 4Ms approach to caring for older adults and conducting resident health assessments. They learned to collect comprehensive health information using a 4Ms Resident Health Risk Assessment (4Ms-RHRA) and results are entered into a customized electronic database. Embedded flags identify potential risk factors and initiate a follow-up process for documenting interventions and tracking referrals to healthcare and supportive services., Results: Eighty-one percent of the 221 4Ms-RHRAs completed with residents (63% female, mean age 71.1 years, 73% live alone) were flagged for at least one concern (Mean = 2.2 flags). Items addressing What Matters were most frequently flagged: resident's "most important health issue" (55%) and Advance Care Planning (ACP: 48%). In response, staff provided Advance Directive forms and Five Wishes pamphlets to interested residents and reminded residents to review ACP documents annually., Conclusion: Training affordable housing staff, precepting faculty, and students to conduct health assessments based on the 4Ms framework and longitudinally track interventions related to resident-centered needs and manage long-term service and supports is a first step in creating an interprofessional workforce capable of addressing the complex needs of older individuals in affordable housing., (© 2024 The Author(s). Journal of the American Geriatrics Society published by Wiley Periodicals LLC on behalf of The American Geriatrics Society.)
- Published
- 2024
- Full Text
- View/download PDF
25. Improving Antibiotic Overuse in Primary Care: A Multimodal Quality Improvement Project.
- Author
-
Wharton A, Jerome-D'Emilia B, and Avallone M
- Subjects
- Humans, Anti-Bacterial Agents therapeutic use, Quality Improvement, Inappropriate Prescribing prevention & control, Primary Health Care, Respiratory Tract Infections drug therapy
- Abstract
Purpose: Antibiotic overuse has increased over time related to provider knowledge gaps about best practices, provider perception of patient expectations on receiving an antibiotic, possible pressure to see patients in a timely fashion, and concerns about decreased patient satisfaction when an antibiotic is not prescribed. The Centers for Disease Control and Prevention estimates that up to 30% of antibiotics are inappropriately prescribed in the outpatient setting., Approach: This quality improvement project consisted of a multimodal approach to decrease inappropriate antibiotic prescribing for viral upper respiratory infections (URIs) by using provider education, passive patient education, and clinical decision support tools based on Centers for Disease Control and Prevention recommendations and the Be Antibiotic Aware tool., Outcomes: Following implementation, there was an 11% decrease in viral URI antibiotic prescribing, from a rate of 29.33% to 18.33% following the multimodal implementation., Conclusion: The use of evidence-based education and treatment guidelines was found to decrease inappropriate antibiotic prescribing for patients diagnosed with viral URIs., Competing Interests: The authors report no conflicts of interest., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
26. Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling.
- Author
-
Avallone M, Pardo J, Mergiya TF, Rájová J, Räsänen A, Davidsson M, Åkerblom M, Quintino L, Kumar D, Bramham CR, and Björklund T
- Abstract
The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein that self-assembles into capsid-like structures harboring Arc mRNA. Arc capsids, released from neurons, have been proposed as a novel intercellular mechanism for mRNA transmission. Nevertheless, evidence for intercellular transport of Arc in the mammalian brain is still lacking. To enable the tracking of Arc molecules from individual neurons in vivo , we devised an adeno-associated virus (AAV) mediated approach to tag the N-terminal of the mouse Arc protein with a fluorescent reporter using CRISPR/Cas9 homologous independent targeted integration (HITI). We show that a sequence coding for mCherry can successfully be knocked in at the 5' end of the Arc open reading frame. While nine spCas9 gene editing sites surround the Arc start codon, the accuracy of the editing was highly sequence-dependent, with only a single target resulting in an in-frame reporter integration. When inducing long-term potentiation (LTP) in the hippocampus, we observed an increase of Arc protein highly correlated with an increase in fluorescent intensity and the number of mCherry-positive cells. By proximity ligation assay (PLA), we demonstrated that the mCherry-Arc fusion protein retains the Arc function by interacting with the transmembrane protein stargazin in postsynaptic spines. Finally, we recorded mCherry-Arc interaction with presynaptic protein Bassoon in mCherry-negative surrounding neurons at close proximity to mCherry-positive spines of edited neurons. This is the first study to provide support for inter-neuronal in vivo transfer of Arc in the mammalian brain., Competing Interests: DK was employed by Aiforia Technologies Oyj. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Avallone, Pardo, Mergiya, Rajova, Räsänen, Davidsson, Åkerblom, Quintino, Kumar, Bramham and Björklund.)
- Published
- 2023
- Full Text
- View/download PDF
27. Deconvolution of spatial sequencing provides accurate characterization of hESC-derived DA transplants in vivo .
- Author
-
Rájová J, Davidsson M, Avallone M, Hartnor M, Aldrin-Kirk P, Cardoso T, Nolbrant S, Mollbrink A, Storm P, Heuer A, Parmar M, and Björklund T
- Abstract
Cell therapy for Parkinson's disease has experienced substantial growth in the past decades with several ongoing clinical trials. Despite increasing refinement of differentiation protocols and standardization of the transplanted neural precursors, the transcriptomic analysis of cells in the transplant after its full maturation in vivo has not been thoroughly investigated. Here, we present spatial transcriptomics analysis of fully differentiated grafts in their host tissue. Unlike earlier transcriptomics analyses using single-cell technologies, we observe that cells derived from human embryonic stem cells (hESCs) in the grafts adopt mature dopaminergic signatures. We show that the presence of phenotypic dopaminergic genes, which were found to be differentially expressed in the transplants, is concentrated toward the edges of the grafts, in agreement with the immunohistochemical analyses. Deconvolution shows dopamine neurons being the dominating cell type in many features beneath the graft area. These findings further support the preferred environmental niche of TH-positive cells and confirm their dopaminergic phenotype through the presence of multiple dopaminergic markers., Competing Interests: The authors declare no competing interests., (© 2023 The Author(s).)
- Published
- 2023
- Full Text
- View/download PDF
28. Characterization of gut microbiota in patients with metabolic syndrome candidates for bariatric/metabolic surgery: Preliminary findings of a multi-center prospective study.
- Author
-
De Maio F, Boru CE, Avallone M, Velotti N, Bianco DM, Capoccia D, Greco F, Guarisco G, Nogara M, Sanguinetti M, Verrastro O, Capaldo B, Musella M, Raffaelli M, Delogu G, Silecchia G, and Leonetti F
- Subjects
- Cohort Studies, Humans, Prospective Studies, Bariatric Surgery, Gastrointestinal Microbiome, Metabolic Syndrome epidemiology
- Abstract
Introduction: gut microbiota (GM) seems to be involved in the pathophysiology and progression of both metabolic syndrome (MS) and obesity. The aim was to investigate GM's composition in patients with severe obesity, candidates for bariatric/metabolic surgery BMS., Materials and Methods: Multicentre, prospective, cohort study, enrolling 84 patients with BMI 40-55 kg/m
2 , divided bymetabolic status (MS) inhealthy(group A), pre-MS (B), or MS (C)., Results: No differences were foundregarding anthropometric,nutritional parameters, except for vitamin D.As a whole the alpha and beta diversity examinations showed no statistical differences in GM profile. A total of 5/7 phyla with relative frequencies were identified above 0.1% (Actinobacteria,Bacteroidetes,Firmicutes,Proteobacteria,Verrucomicrobia).FusobacteriaandPatescibacteriarepresented the less abundant. There were no significant differences in the top ten genera.Data onBacteroidetes(inversely related to triglycerides and LDL and directly related to HDL levels) and onFirmicutes(opposite trend) relative abundances suggest no differences among the three conditions.No correlation between the relative abundance of themain phylaand plasmatic glucose levels was observed., Conclusions: In a selected cohort of patients with obesity, MS did not affect the preoperative GM's profile. Severe obesity, per se, seems to be an independent condition affecting GM., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021. Published by Elsevier B.V.)- Published
- 2021
- Full Text
- View/download PDF
29. Using the 4Ms framework to teach geriatric competencies in a community clinical experience.
- Author
-
Avallone M, Perweiler E, and Pacetti S
- Subjects
- Clinical Competence statistics & numerical data, Community Participation methods, Community Participation psychology, Community Participation statistics & numerical data, Geriatric Nursing standards, Geriatric Nursing statistics & numerical data, Humans, New Jersey, Problem-Based Learning methods, Problem-Based Learning standards, Problem-Based Learning statistics & numerical data, Clinical Competence standards, Geriatric Nursing methods
- Abstract
Background: As the population of older adults in the US steadily increases and becomes more diverse, there is an urgent need to integrate geriatric competencies into baccalaureate nursing education., Purpose: To integrate the Institute for Healthcare Improvement 4 Ms Framework into an existing baccalaureate nursing community clinical experience to build geriatric and interprofessional competencies and promote positive health outcomes., Methods: As part of the Geriatric Workforce Enhancement Program, 15 students worked with bilingual social workers and community health workers in an affordable housing urban highrise, assessed building residents and implemented personalized plans of care using the 4Ms framework (what matters to the individual, medications, mentation, and mobility)., Results: Students demonstrated competence conducting cognition and depression screening, medication review, and functional and fall risk assessments. Student self-rated achievement of learning objectives ranged from 4.3 to 4.8 (1-5 scale). A retrospective pretest-posttest survey suggested learning about the importance of interprofessional teamwork, and integration of person-centered values when providing care to older adults in the community. Students reflected on barriers to health for older adults in low socioeconomic states and the importance of improving care across the continuum., Conclusion: The 4Ms framework provided a valuable construct to guide the community experience and teach geriatric evidence-based practice to nursing students., (© 2020 Wiley Periodicals LLC.)
- Published
- 2021
- Full Text
- View/download PDF
30. Using new careers in nursing research findings to develop an evidence-based pre-entry immersion program.
- Author
-
Cantwell ER, Avallone M, and Bowler G
- Subjects
- Humans, Immersion, Nursing Education Research, Education, Nursing, Baccalaureate, Nursing Research, Students, Nursing
- Abstract
Background: New Careers In Nursing (NCIN) data analysis results were used to inform the development of The Bridge to Nursing Success Program (Bridge). NCIN data revealed that participation in a pre-entry immersion program (PIP) was associated with higher rates of retention and graduation., Purpose: The purpose of this article is to 1). describe the findings of the NCIN Scholarship Program in relation to pre-entry immersion (PIP) programs. 2). Discuss and report the development of The Bridge to Nursing Success Program 3). Report results of the Bridgeto Nursing Success Program., Method: The Bridge to Nursing Success Program (Bridge Program) was developed based on NCIN findings. Two Bridge cohorts (N = 44) of accelerated nursing students participated in a nine-day pre-immersion program (PIP) that included face to face classes and discussions. Post program surveys were administered to assess helpfulness of program content., Findings: Student evaluations revealed an overwhelmingly positive response to the program. Both Bridge participants and non-Bridge participants performed equally through the first semester. Students who participated in the Bridge Program were less likely to fail a course in the first semester, and Bridge participants were six times more likely to be successful in the pathophysiology course., Discussion: The study provides an evidence-based PIP model that offers academic support and coping strategies prior to an accelerated nursing program. Long-term follow up of the participating cohorts may reveal whether there is a relationship to this PIP program and persistence through to graduation., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
31. GDNF-mediated rescue of the nigrostriatal system depends on the degree of degeneration.
- Author
-
Quintino L, Avallone M, Brännstrom E, Kavanagh P, Lockowandt M, Garcia Jareño P, Breger LS, and Lundberg C
- Subjects
- Animals, Female, Glial Cell Line-Derived Neurotrophic Factor metabolism, Lentivirus genetics, Oxidopamine toxicity, Parkinson Disease etiology, Rats, Rats, Sprague-Dawley, Striatonigral Degeneration etiology, Substantia Nigra metabolism, Substantia Nigra pathology, Genetic Therapy methods, Glial Cell Line-Derived Neurotrophic Factor genetics, Parkinson Disease therapy, Striatonigral Degeneration therapy
- Abstract
Glial cell-line derived neurotrophic factor (GDNF) is a promising therapeutic molecule to treat Parkinson's disease. Despite an excellent profile in experimental settings, clinical trials testing GDNF have failed. One of the theories to explain these negative outcomes is that the clinical trials were done in late-stage patients that have advanced nigrostriatal degeneration and may therefore not respond to a neurotrophic factor therapy. Based on this idea, we tested if the stage of nigrostriatal degeneration is important for GDNF-based therapies. Lentiviral vectors expressing regulated GDNF were delivered to the striatum of rats to allow GDNF expression to be turned on either while the nigrostriatal system was degenerating or after the nigrostriatal system had been fully lesioned by 6-OHDA. In the group of animals where GDNF expression was on during degeneration, neurons were rescued and there was a reversal of motor deficits. Turning GDNF expression on after the nigrostriatal system was lesioned did not rescue neurons or reverse motor deficits. In fact, these animals were indistinguishable from the control groups. Our results suggest that GDNF can reverse motor deficits and nigrostriatal pathology despite an ongoing nigrostriatal degeneration, if there is still a sufficient number of remaining neurons to respond to therapy.
- Published
- 2019
- Full Text
- View/download PDF
32. Leak after sleeve gastrectomy: how long do we have to be worried?
- Author
-
Iossa A, Caporilli D, Avallone M, Ciccioriccio MC, and Silecchia G
- Subjects
- Adult, Female, Humans, Anastomotic Leak diagnosis, Anastomotic Leak therapy, Gastrectomy methods, Obesity, Morbid surgery
- Published
- 2018
- Full Text
- View/download PDF
33. Destabilizing Domains Enable Long-Term and Inert Regulation of GDNF Expression in the Brain.
- Author
-
Quintino L, Namislo A, Davidsson M, Breger LS, Kavanagh P, Avallone M, Elgstrand-Wettergren E, Isaksson C, and Lundberg C
- Abstract
Regulation of therapeutic transgene expression can increase the safety of gene therapy interventions, especially when targeting critical organs such as the brain. Although several gene expression systems have been described, none of the current systems has the required safety profile for clinical applications. Our group has previously adapted a system for novel gene regulation based on the destabilizing domain degron technology to successfully regulate glial cell-line derived neurotrophic factor in the brain (GDNF-F-DD). In the present study, we used GDNF-F-DD as a proof-of-principle molecule to fully characterize DD regulation in the brain. Our results indicate that DD could be regulated in a dose-dependent manner. In addition, GDNF-F-DD could also be induced in vivo repeatedly, without loss of activity or efficacy in vivo . Finally, DD regulation was able to be sustained for 24 weeks without loss of expression or any overt toxicity. The present study shows that DD has great potential to regulate gene expression in the brain.
- Published
- 2018
- Full Text
- View/download PDF
34. Usefulness of Upper Gastrointestinal Symptoms as a Driver to Prescribe Gastroscopy in Obese Patients Candidate to Bariatric Surgery. A Prospective Study.
- Author
-
Carabotti M, Avallone M, Cereatti F, Paganini A, Greco F, Scirocco A, Severi C, and Silecchia G
- Subjects
- Abdominal Pain etiology, Adolescent, Adult, Bariatric Surgery, Female, Gastroesophageal Reflux complications, Humans, Male, Middle Aged, Obesity, Morbid complications, Postprandial Period, Preoperative Care, Prospective Studies, Surveys and Questionnaires, Young Adult, Dyspepsia etiology, Esophagoscopy, Gastroesophageal Reflux diagnosis, Gastroscopy, Obesity, Morbid surgery
- Abstract
Background: Before bariatric surgery, the necessity of routine upper gastrointestinal endoscopy is controversial, and guidelines recommend endoscopy in symptomatic cases. However, impaired visceral sensation occurring in obese patients may be misleading. The purpose of the study is to evaluate prospectively the prevalence of gastrointestinal symptoms, endoscopic findings, and the relation between symptoms and endoscopic findings in obese patients before surgery., Materials and Methods: One hundred forty-two consecutive patients candidate to primary bariatric surgery filled out the validated Rome III symptomatic questionnaire and performed endoscopy., Results: With a median age of 41 years and BMI of 44 Kg/m(2), 83% were females. Symptoms were referred by 43% of patients: gastroesophageal reflux disease (GERD) (27.9%) and dyspepsia (24.6%), subdivided in postprandial distress (PDS) (66.7%) and epigastric pain (33.3%) syndromes. Of GERD patients, 19.7% presented concomitantly PDS. Belching was present in 8.2% and nausea and/or vomiting in 1.6% of patients. At endoscopy, one or more lesions were present in 47.1% of the patients: erosive esophagitis (5.6%), hiatal hernia (23.2%), gastroduodenal erosions (6.3%), and peptic ulcers (3.5%). At histology, 24% of patients have Helicobacter pylori infection, and its prevalence in gastroduodenal erosions and ulcers was 22.2 and 60%, respectively. Surprisingly, in patients with peptic lesions H. pylori-negative, no chronic use of NSAIDs was reported. Analyzing the coexistence of symptoms and lesions, these resulted equally distributed beyond the presence of symptoms, being present in 44.2 and 49.4% of symptomatic and asymptomatic patients, respectively., Conclusions: The presence of symptoms cannot be considered as a valuable guide to indicate endoscopy since the majority of endoscopic lesions were asymptomatic and not H. pylori-related.
- Published
- 2016
- Full Text
- View/download PDF
35. Excitatory Transmission to the Lateral Habenula Is Critical for Encoding and Retrieval of Spatial Memory.
- Author
-
Mathis V, Cosquer B, Avallone M, Cassel JC, and Lecourtier L
- Subjects
- 6-Cyano-7-nitroquinoxaline-2,3-dione pharmacology, Analysis of Variance, Animals, Cues, Drug Administration Schedule, Excitatory Amino Acid Antagonists pharmacology, GABA-A Receptor Agonists pharmacology, Habenula drug effects, Male, Maze Learning drug effects, Motor Activity drug effects, Muscimol pharmacology, Psychomotor Performance drug effects, Rats, Rats, Long-Evans, Retention, Psychology drug effects, Spatial Memory drug effects, Habenula physiology, Spatial Memory physiology
- Abstract
The lateral habenula (LHb) is viewed as a relay between the limbic system, the basal ganglia (BG), and monoaminergic neurons of the midbrain. If a prominent role has been evidenced in BG-mediated functions such as value-based decision-making, very little is known about the involvement of the LHb in limbic functions such as memory processing. In the present study, we used two pharmacological approaches-LHb reversible inactivation with intra-LHb infusion of muscimol, an agonist of the GABA-A receptor, or blockade of excitatory inputs with intra-LHb infusion of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), an antagonist of the glutamatergic AMPA receptor-to investigate the involvement of the LHb in encoding, consolidation, and retrieval of spatial memory in the water maze (WM) in rats. We found that intra-LHb infusion of muscimol or CNQX prevented encoding and retrieval, but not consolidation of spatial information. In addition, muscimol but not CNQX induced impairments during a cued version of the WM task, and marked anxiety in the elevated plus maze. These results confirm the involvement of the LHb in higher cognitive functions. They further suggest a dichotomy between the role of glutamatergic and other inputs to the LHb in hippocampus-dependent memory processing, as well as in emotional aspects of goal-directed behaviors.
- Published
- 2015
- Full Text
- View/download PDF
36. A prospective evaluation on external jugular vein cut-down approach for TIVAD implantation.
- Author
-
Cavallaro G, Iorio O, Iossa A, De Angelis F, Avallone M, Massaro M, Mattia C, and Silecchia G
- Subjects
- Equipment Design, Female, Follow-Up Studies, Humans, Male, Middle Aged, Patient Selection, Prognosis, Prospective Studies, Risk Assessment, Risk Factors, Catheterization, Central Venous instrumentation, Catheters, Indwelling, Jugular Veins surgery, Neoplasms surgery
- Abstract
Background: Totally implantable venous access devices can be implanted both by percutaneous approaches and by surgical approaches with cephalic vein or external jugular vein cut-down techniques that are related to low intraoperative complication rates. The authors report a prospective evaluation of 83 consecutive external jugular vein cut-down approaches for totally implantable venous access devices implantation., Methods: Eighty three consecutive patients (28 M, 55 F, mean age 54.2) suffering from solid tumors (58) or hematologic diseases (25) were consecutively submitted to totally implantable venous access devices insertion through external jugular vein cut-down approach (75 on right side, 8 on left side)., Results: All devices were surgically implanted; no instances of intraoperative complications were detected. After a minimum follow-up of 150 days, only one case of wound hematoma and one case of device malfunction due to incorrect catheter angulation were noted. Postoperative patient satisfaction was evaluated by the use of specific questionnaire that demonstrated a good satisfaction and compliance (92.8%) of patients with implanted devices., Conclusions: Despite the lack of controlled studies comparing external jugular vein cut-down approach vs other approaches, this approach should be considered as a tool for long-term central vein catheters positioning, both as an alternative and for primary approach.
- Published
- 2015
- Full Text
- View/download PDF
37. Surgical treatment of cervical schwannomas arising from the vagus.
- Author
-
Cavallaro G, Pattaro G, Avallone M, Iorio O, and Silecchia G
- Subjects
- Adult, Cranial Nerve Neoplasms pathology, Head and Neck Neoplasms pathology, Humans, Male, Neurilemmoma pathology, Cranial Nerve Neoplasms surgery, Head and Neck Neoplasms surgery, Neurilemmoma surgery, Vagus Nerve
- Published
- 2015
38. A literature review on surgery for cervical vagal schwannomas.
- Author
-
Cavallaro G, Pattaro G, Iorio O, Avallone M, and Silecchia G
- Subjects
- Head and Neck Neoplasms pathology, Humans, Neurilemmoma pathology, Prognosis, Vagus Nerve Diseases pathology, Head and Neck Neoplasms surgery, Neurilemmoma surgery, Postoperative Complications, Vagus Nerve Diseases surgery
- Abstract
Cervical vagal schwannoma is a benign, slow-growing mass, often asymptomatic, with a very low lifetime risk of malignant transformation in general population, but diagnosis is still a challenge. Surgical resection is the treatment of choice even if its close relationship with nerve fibres, from which it arises, threats vagal nerve preservation. We present a case report and a systematic review of literature. All studies on surgical resection of cervical vagal schwannoma have been reviewed. Papers matching the inclusion criteria (topic on surgical removal of cervical vagal schwannoma, English language, full text available) were selected. Fifty-three patients with vagal neck schwannoma submitted to surgery were identified among 22 studies selected. Female/male ratio was 1.5 and median age 44 years. Median diameter was 5 cm (range 2 to 10). Most schwannoma were asymptomatic (68.2%) and received an intracapsular excision (64.9%). Postoperative symptoms were reported in 22.6% of patients. Cervical vagal schwannoma is a benign pathology requiring surgical excision, but frequently postoperative complications can affect patients lifelong, so, surgical indications should be based carefully on the balance between risks and benefits.
- Published
- 2015
- Full Text
- View/download PDF
39. Small bowel intussussception due to metastatic melanoma of unknown primary site. Case report.
- Author
-
Stagnitti F, Orsini S, Martellucci A, Tudisco A, Avallone M, Aiuti F, Di Girolamo V, Stefanelli F, De Angelis F, Di Grazia C, Napoleoni A, Nicodemi S, Cipriani B, Ceci F, Mosillo R, Corelli S, Casciaro G, and Spaziani E
- Subjects
- Humans, Male, Middle Aged, Ileal Neoplasms complications, Ileal Neoplasms secondary, Intestinal Obstruction etiology, Melanoma complications, Melanoma secondary, Neoplasms, Unknown Primary pathology
- Abstract
Malignant melanoma is characterized by metastases also to the gastrointestinal tract, especially in the small bowel. The diagnosis is often delayed because unspecific clinical presentation (frequently as chronic iron deficiency anemia, rectal bleeding or intestinal obstruction). We present a case of melanoma of unknown primary site, with clinical presentation of intestinal obstruction. A segmental resection of the ileum was performed including mesentery with lymph nodes. Histology revealed metastatic melanoma from unknown primary. PET and MRI confirmed disseminated disease without brain metastasis.
- Published
- 2014
40. Biliodigestive fistulae and gallstone ileus: diagnostic and therapeutic considerations. Our experience.
- Author
-
Stagnitti F, Tudisco A, Ceci F, Nicodemi S, Orsini S, Avallone M, Di Girolamo V, Stefanelli F, De Angelis F, Di Grazia C, Cipriani B, Aiuti F, Napoleoni A, Mosillo R, Corelli S, Casciaro G, Costantino A, Martellucci A, and Spaziani E
- Subjects
- Adolescent, Aged, Aged, 80 and over, Female, Gallstones complications, Humans, Ileus etiology, Male, Middle Aged, Biliary Fistula diagnosis, Biliary Fistula surgery, Gallstones diagnosis, Gallstones surgery, Ileus diagnosis, Ileus surgery, Intestinal Fistula diagnosis, Intestinal Fistula surgery
- Abstract
The biliodigestive fistula is not a rare affection in the context of acute pathology of the gastrointestinal tract. It often affects patients between 63 and 85 years old , particularly the female sex, and the most common cause is acute or chronic cholecystolithiasis. Open issues are the delayed in the pre-operative diagnosis, and controversies exist regarding the best surgical approach. The choice of treatment options is influenced by the age of the patients and their clinical conditions and also by the presence of comorbidities and of a delayed right diagnosis. In the 1 to 3% of cases, the biliodigestive fistula presents a gallstone ileus as complication, whose diagnosis is particularly difficult for the lack of specific signs and symptoms. The contrast-enhanced CT is considered the gold standard for a specific pre-operative diagnosis, as it directly shows the fistula. Surgical treatments include one-stage procedure or two-stage procedure. Many studies seem to favor a deferred definitive procedure. The Authors describe 4 cases: in 3 cases, women between 70 and 80 years old presenting an history of recurrent cholecystitis, in 2 cases, and in 1 case presenting a bowel obstruction; in 1 case a 50-years-old man, with no significant past medical history, presenting a bowel obstruction. The Authors have performed in the 2 cases of gallstone ileus an enterolithotomy with cholecysto-duodenal fistula repair and cholecystectomy, in one-stage, and this has been possible because of the good clinical conditions of the patients and their low operative risk. In the case of fistula without the complication of gallstone ileus, the treatment approach has been cholecysto-gastric fistula closure with a gastroplastic using separate stitches and cholecystectomy, in one-stage. We are in agreement with data in the literature regarding the delay into the diagnosis of biliodigestive fistula and with the importance to suspect it or gallstone ileus presence, although the clinical presentation is extremely non-specific. In our experience, cholangiopancreatography-CT and CECT have made easier the pre-operative diagnosis and so reducing the delay of the treatment.
- Published
- 2014
41. Multiorgan female pelvic prolapse: pelvic organ prolapse suspension (P.O.P.S.) stapled transanal rectale resection (S.T.A.R.R.): new surgical tecniques and results.
- Author
-
Ceci F, Spaziani E, Casciaro G, Corelli S, Martellucci A, Costantino A, Nicodemi S, Avallone M, Orsini S, Tudisco A, Aiuti F, and Stagnitti F
- Subjects
- Anal Canal, Female, Gynecologic Surgical Procedures methods, Humans, Middle Aged, Rectum surgery, Surgical Stapling, Pelvic Organ Prolapse surgery
- Abstract
Aim: To demonstrate the surgical treatment validity and the post-operative complication decrease., Material of Study: Seventythree women who underwent P.O.P.S. + S.T.A.R.R. treatment, follow-up one year., Results: We observed an important reduction or a completely disappearance about pre-operative signs and symptoms., Discussion: We are aware that the proposed technique, if taken into account by urogynecologists, will raise several arguments and will raise many doubts and perplexities. For this reason we wanted develop a follow-up sufficiently long and many case studies with data to support our claims., Conclusions: We believe that the procedure proposed by us, given the results, was excellent in patients with multiorgan pelvic prolapse, especially with the vagina walls elongated and that retain a good trophism.
- Published
- 2013
42. Single-incision laparoscopic appendectomy is comparable to conventional laparoscopic and laparotomic appendectomy: our single center single surgeon experience.
- Author
-
Ceci F, Orsini S, Tudisco A, Avallone M, Aiuti F, Di Girolamo V, Stefanelli F, De Angelis F, Martellucci A, Costantino A, Di Grazia C, Nicodemi S, Cipriani B, Napoleoni A, Mosillo R, Corelli S, Casciaro G, Spaziani E, and Stagnitti F
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Retrospective Studies, Young Adult, Appendectomy methods, Laparoscopy methods, Laparotomy
- Abstract
Several studies have demonstrated the clinical and technical benefits of the laparoscopic surgery for complicated and uncomplicated appendicitis. Our retrospective study included 12 patient who underwent SILS appendectomy (SILS-A), 14 who received conventional laparoscopic surgery (VL-A), and 12 who received laparotomic appendectomy (OA); performed in all cases by the same surgeon (C.F.). The aim of this study was the comparison between this three different surgical techniques on same features: post operative leukocytosis, post operative pain, need abdominal drainage, esthetic viewpoint, incidence of complication, hospital stay. The results showed no significant differences between SILS-A and VLS-A, while an evident improvement shows versus O-A, even though not statistically significative. SILS was more effective in decreasing the risk of postoperative wound infection.
- Published
- 2013
- Full Text
- View/download PDF
43. Technique and outcomes about a new laparoscopic procedure: the Pelvic Organ Prolapse Suspension (POPS).
- Author
-
Ceci F, Spaziani E, Corelli S, Casciaro G, Martellucci A, Costantino A, Napoleoni A, Cipriani B, Nicodemi S, Di Grazia C, Avallone M, Orsini S, Tudisco A, Aiuti F, and Stagnitti F
- Subjects
- Female, Follow-Up Studies, Gynecologic Surgical Procedures methods, Humans, Middle Aged, Treatment Outcome, Laparoscopy, Pelvic Organ Prolapse surgery
- Abstract
Pelvic organ prolapse suspension (POPS) is a recent surgical procedure for one-stage treatment of multiorgan female pelvic prolapse. This study evaluates the preliminary results of laparoscopic POPS in 54 women with a mean age of 55.2 and a BMI of 28.3. Patients underwent at the same time stapled transanal rectal resection (STARR) to correct the residual rectal prolapse. We had no relapses and the preliminary results were excellent. We evaluated the patients after 1 year follow-up and we confirmed the validity of our treatment. The technique is simpler than traditional treatments with an important reduction or completely disappearance of the pre-operative symptomatology.
- Published
- 2013
- Full Text
- View/download PDF
44. Identification of copy number alterations and its association with pathological features in clear cell and papillary RCC.
- Author
-
Matsuda D, Khoo SK, Massie A, Iwamura M, Chen J, Petillo D, Wondergem B, Avallone M, Kloostra SJ, Tan MH, Koeman J, Zhang Z, Kahnoski RJ, Baba S, and Teh BT
- Subjects
- Aged, Base Sequence, Carcinoma, Papillary pathology, Carcinoma, Renal Cell pathology, Chromosomes, Human, DNA Primers, Female, Humans, In Situ Hybridization, Fluorescence, Kidney Neoplasms pathology, Male, Middle Aged, Mutation, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Von Hippel-Lindau Tumor Suppressor Protein genetics, Carcinoma, Papillary genetics, Carcinoma, Renal Cell genetics, Kidney Neoplasms genetics
- Abstract
We report and characterize the copy number alterations (CNAs) in 35 clear cell and 12 papillary renal cell carcinomas (RCC) using Affymetrix 100K SNP arrays. Novel gain and loss regions are identified in both subtypes. In addition, statistically significant CNA are detected and associated with the pathological features: VHL mutation status, tumor grades, and sarcomatoid component in clear cell RCC and in types 1 and 2 of papillary RCC. Florescence in situ hybridization confirmed the copy number gain in the transforming growth factor, beta-induced gene (TGFBI), which is a possible oncogene for clear cell RCC.
- Published
- 2008
- Full Text
- View/download PDF
45. Attitudes, knowledge, and health-seeking behaviors of five immigrant minority communities in the prevention and screening of cancer: a focus group approach.
- Author
-
Gany FM, Herrera AP, Avallone M, and Changrani J
- Subjects
- Adult, Cultural Characteristics, Female, Focus Groups, Humans, Language, Male, Mass Screening, Neoplasms epidemiology, New York City epidemiology, Socioeconomic Factors, Emigration and Immigration, Ethnicity statistics & numerical data, Health Knowledge, Attitudes, Practice, Neoplasms ethnology, Neoplasms prevention & control, Patient Acceptance of Health Care
- Abstract
Despite an observed decrease in overall cancer death rates in the USA, immigrant minorities continue to experience disproportionately higher cancer incidence and mortality rates. Thirteen focus groups were conducted in the Haitian, English-Speaking Caribbean, Latino, Korean, and Chinese communities of New York City to better understand their health-seeking behaviors with respect to cancer prevention, screening, and treatment. Focus groups addressed the degree to which cultural, linguistic, and systematic barriers impact these behaviors and explored methods to support salutary behaviors. Findings underscored that, while there are many similarities across immigrant groups, there are significant variations between the immigrant groups to necessitate a tailored community-based approach. The prevalent misinformation observed among all groups warrants the prompt development of culturally competent programs for cancer control with immigrant minorities.
- Published
- 2006
- Full Text
- View/download PDF
46. A comparison of dietary behaviour in Central England and a French Mediterranean region.
- Author
-
Holdsworth M, Gerber M, Haslam C, Scali J, Beardsworth A, Avallone MH, and Sherratt E
- Subjects
- Adult, Aged, Diet trends, Diet Surveys, Dietary Supplements, Energy Intake, England epidemiology, Female, France epidemiology, Fruit metabolism, Humans, Male, Meat, Middle Aged, Surveys and Questionnaires, Vegetables metabolism, Diet statistics & numerical data, Neoplasms prevention & control
- Abstract
Unlabelled: BJECTIVEe: The investigation involves comparison of dietary behaviour between UK and Mediterranean France by characterizing the pattern of the current French Mediterranean diet compared with the current British diet., Design: The findings of two dietary surveys, one in the UK and one in France, are compared. An interviewer-administered questionnaire was used in both countries. Questions on food frequency were used to assess dietary behaviour, which were regrouped in the French survey to correspond with UK groupings. Dietary indices were constructed to describe dietary behaviour in relation to cancer recommendations for intake of fat, fibre, meat, fruit and vegetables., Setting: The UK study was conducted in Leicestershire, central England and the French study was carried out in Hérault, southern France., Subjects: UK: n=418 subjects (57.9% female and 42.1% male; mean age=45.0 y); France: n=635 subjects (50.1% female and 40.9% male; mean age=49.8 y). Age range of both samples: 20-74 y., Results: There were positive and negative trends in food consumption in each country. UK respondents reported eating more beans and pulses (P=0.000), less cheese (P=0. 000), red meat (P=0.001), and processed meats (P=0.000) than French respondents. However, on the negative side, they ate less fruit and vegetables (P=0.000), fish and poultry (P=0.000), cereals (P=0.000), and more sweets and chocolates (P=0.000), and cakes, pastries, biscuits and puddings (P=0.000). Women had healthier diets in both countries., Conclusions: Overall the southern French diet was healthier as French respondents scored significantly better for indices for fat, dietary fibre, fruit and vegetables (P=0.000 in all cases). However, the French sample scored poorer for the meat index (P=0.000)., Sponsorship: This study was supported by a grant from l'Association de la Recherche contre le Cancer (ARC) awarded to M Holdsworth.
- Published
- 2000
- Full Text
- View/download PDF
47. Mammary hamartomas: an immunohistochemical study of ten cases.
- Author
-
Chiacchio R, Panico L, D'Antonio A, Delrio P, Bifano D, Avallone M, and Pettinato G
- Subjects
- Adult, Biomarkers, Tumor metabolism, Breast Neoplasms pathology, Female, Hamartoma pathology, Humans, Immunohistochemistry, Middle Aged, Receptors, Estrogen metabolism, Receptors, Progesterone metabolism, Retrospective Studies, Breast Neoplasms metabolism, Hamartoma metabolism
- Abstract
Ten cases of breast hamartomas were reviewed; the patients' age ranged from 31 to 55 (mean 40.4, median 39). All cases presented with a palpable, sometimes tender, lump. The typical mammographic feature was a well defined, round to lens shaped, variable dense mass, occasionally surrounded by a thin radiolucent zone. All hamartomas were unilateral (4 in the right and 6 in the left breast, respectively) and no recurrence occurred after local excision. The tumor size ranged from 5 to 150 mm (mean 54 mm). Histologically all hamartomas were composed of a typical fibrous, adipose and glandular tissue combination. Immunohistochemically there was a strong positivity for cytokeratin and epithelial membrane antigen in the epithelial cells, a positive finding for vimentin and muscle-specific actin in stromal and myoepithelial cells, and for S-100 protein in myoepithelial cells. Vessels endothelial cells were immunoreactive for Factor VIII. Immunohistochemical analysis of hormone receptors completed on formaldehyde-fixed paraffin-embedded specimens, showed estrogen and progesterone receptors positivity in 9 cases and estrogen positive progesterone negative receptors in one case. In all cases the receptorial positivity was limited to the epithelial elements. These data revealed that 1) breast hamartoma is a benign, tumor-like lesion, histologically dissimilar from other lesions such as fibroadenoma and pseudoangiomatous hyperplasia; and 2) hamartoma tissue is influenced by hormones like the surrounding normal breast parenchyma.
- Published
- 1999
- Full Text
- View/download PDF
48. [Benign lesions of the breast].
- Author
-
Pettinato G, Panico L, de Rosa N, D'Antonio A, Bifano D, and Avallone M
- Subjects
- Breast Neoplasms pathology, Breast Neoplasms surgery, Diagnosis, Differential, Female, Humans, Biopsy, Breast Diseases pathology, Breast Diseases surgery
- Abstract
Benign lesions represent the most frequent lesions of the breast. Such lesions often onset with nodules or palpable masses simulating a breast cancer. In uncertain cases, an excisional biopsy may be at the same time a diagnostic and a therapeutic solution. A high percentage (40%) of the diagnosed lesions belongs to fibrocystic disease. A remaining 50% can be shared among tumor-like lesions, inflammatory lesions or benign tumors like fibroadenomas. Only in the 10% of palpable breast masses, biopsy reveals a breast cancer. The role of the pathologist is strictly related to the surgeon's one. Clinically benign lesions may be excised throughout a biopsy performed under local anesthesia. Clinically uncertain lesion must be evaluated by a fine needle aspiration biopsy (FNAB), nevertheless in some cases the doubt may persist. In such cases an excisional biopsy performed while the patient is under general anesthesia may finally solve the question. In case of breast malignancies the intervention can be enlarged as described for cancer.
- Published
- 1997
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.